Recent advances in the therapeutic application of short-chain fatty acids (SCFAs): An updated review

References

• Ahmadi, S., R. Nagpal, S. Wang, J. Gagliano, D. W. Kitzman, S. Soleimanian-Zad, M. Sheikh-Zeinoddin, R. Read, and H. Yadav. 2019. Prebiotics from acorn and sago prevent high-fat-diet-induced insulin resistance via microbiome-gut-brain axis modulation. The Journal of Nutritional Biochemistry 67:1–13. doi: 10.1016/j.jnutbio.2019.01.011.
   PubMed Web of Science ®Google Scholar
• Alva-Murillo, N., A. Ochoa-Zarzosa, and J. E. López-Meza. 2012. Short chain fatty acids (propionic and hexanoic) decrease Staphylococcus aureus internalization into bovine mammary epithelial cells and modulate antimicrobial peptide expression. Veterinary Microbiology 155 (2–4):324–31. doi: 10.1016/j.vetmic.2011.08.025.
   PubMed Web of Science ®Google Scholar
• Álvarez-Ordóñez, A., M. Begley, M. Prieto, W. Messens, M. López, A. Bernardo, and C. Hill. 2011. Salmonella spp. survival strategies within the host gastrointestinal tract. Microbiology (Reading, England) 157 (Pt 12):3268–81. doi: 10.1099/mic.0.050351-0.
   PubMedGoogle Scholar
• Aoyama, M., J. Kotani, and M. Usami. 2010. Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41/GPR-43 pathways. Nutrition (Burbank, Los Angeles County, Calif.) 26 (6):653–61. doi: 10.1016/j.nut.2009.07.006.
   PubMed Web of Science ®Google Scholar
• Arora, T., R. Sharma, and G. Frost. 2011. Propionate. Anti-obesity and satiety enhancing factor? Appetite 56 (2):511–5. doi: 10.1016/j.appet.2011.01.016.
   PubMed Web of Science ®Google Scholar
• Aune, D., D. S. Chan, R. Lau, R. Vieira, D. C. Greenwood, E. Kampman, and T. Norat. 2011. Dietary fibre, whole grains, and risk of colorectal cancer: Systematic review and dose-response meta-analysis of prospective studies. BMJ (Clinical Research ed.) 343:d6617 doi: 10.1136/bmj.d6617.
   PubMed Web of Science ®Google Scholar
• Baothman, O. A., M. A. Zamzami, I. Taher, J. Abubaker, and M. Abu-Farha. 2016. The role of gut microbiota in the development of obesity and diabetes. Lipids Health Dis. 15:108 doi: 10.1186/s12944-016-0278-4.
   PubMed Web of Science ®Google Scholar
• Berndt, B. E., M. Zhang, S. Y. Owyang, T. S. Cole, T. W. Wang, J. Luther, N. A. Veniaminova, J. L. Merchant, C.-C. Chen, G. B. Huffnagle, et al. 2012. Butyrate increases IL-23 production by stimulated dendritic cells. The American Journal of Physiology-Gastrointestinal and Liver Physiology 303 (12):G1384–G1392., doi: 10.1152/ajpgi.00540.2011.
   PubMed Web of Science ®Google Scholar
• Boets, E., S. V. Gomand, L. Deroover, T. Preston, K. Vermeulen, V. De Preter, H. M. Hamer, G. Van den Mooter, L. De Vuyst, C. M. Courtin, et al. 2017. Systemic availability and metabolism of colonic‐derived short‐chain fatty acids in healthy subjects: A stable isotope study. The Journal of Physiology 595 (2):541–55. doi: 10.1113/JP272613.
   PubMed Web of Science ®Google Scholar
• Borthakur, A., R. K. Gill, K. Hodges, K. Ramaswamy, G. Hecht, and P. K. Dudeja. 2006. Enteropathogenic Escherichia coli inhibits butyrate uptake in Caco-2 cells by altering the apical membrane MCT1 level. American Journal of Physiology. Gastrointestinal and Liver Physiology 290 (1):G30–G35. doi: 10.1152/ajpgi.00302.2005.
   PubMed Web of Science ®Google Scholar
• Bowman, J. P., K. J. L. Chang, T. Pinfold, and T. Ross. 2010. Transcriptomic and phenotypic responses of Listeria monocytogenes strains possessing different growth efficiencies under acidic conditions. Applied and Environmental Microbiology 76 (14):4836–50. doi: 10.1128/AEM.00315-10.
   PubMed Web of Science ®Google Scholar
• Bowman, J. P., E. Hages, R. E. Nilsson, C. Kocharunchitt, and T. Ross. 2012. Investigation of the Listeria monocytogenes Scott A acid tolerance response and associated physiological and phenotypic features via whole proteome analysis. Journal of Proteome Research 11 (4):2409–26. doi: 10.1021/pr201137c.
   PubMed Web of Science ®Google Scholar
• Boyen, F., F. Haesebrouck, A. Vanparys, J. Volf, M. Mahu, F. Van Immerseel, I. Rychlik, J. Dewulf, R. Ducatelle, and F. Pasmans. 2008. Coated fatty acids alter virulence properties of Salmonella Typhimurium and decrease intestinal colonization of pigs. Veterinary Microbiology 132 (3-4):319–27. doi: 10.1016/j.vetmic.2008.05.008.
   PubMed Web of Science ®Google Scholar
• Burokas, A., S. Arboleya, R. D. Moloney, V. L. Peterson, K. Murphy, G. Clarke, C. Stanton, T. G. Dinan, and J. F. Cryan. 2017. Targeting the microbiota-gut-brain axis: Prebiotics have anxiolytic and antidepressant-like effects and reverse the impact of chronic stress in mice. Biological Psychiatry 82 (7):472–87. doi: 10.1016/j.biopsych.2016.12.031.
   PubMed Web of Science ®Google Scholar
• Callaway, T., T. Edrington, R. Anderson, J. Byrd, and D. Nisbet. 2008. Gastrointestinal microbial ecology and the safety of our food supply as related to Salmonella. Journal of Animal Science 86 (14 Suppl):E163–E172. doi: 10.2527/jas.2007-0457.
   PubMedGoogle Scholar
• Calvo, J. M., and R. G. Matthews. 1994. The leucine-responsive regulatory protein, a global regulator of metabolism in Escherichia coli. Microbiological Reviews 58 (3):466–90.
   PubMedGoogle Scholar
• Canfora, E. E., C. M. van der Beek, J. W. Jocken, G. H. Goossens, J. J. Holst, S. W. O. Damink, K. Lenaerts, C. H. Dejong, and E. E. Blaak. 2017. Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: A randomized crossover trial. Scientific Reports 7 (1):12. doi: 10.1038/s41598-017-02546-x.
   PubMedGoogle Scholar
• Casellas, F., N. Borruel, A. Torrejon, E. Varela, M. Antolin, F. Guarner, and J. R. Malagelada. 2007. Oral oligofructose‐enriched inulin supplementation in acute ulcerative colitis is well tolerated and associated with lowered faecal calprotectin. Alimentary Pharmacology & Therapeutics 25 (9):1061–7. doi: 10.1111/j.1365-2036.2007.03288.x.
   PubMed Web of Science ®Google Scholar
• Cavaglieri, C. R., A. Nishiyama, L. C. Fernandes, R. Curi, E. A. Miles, and P. C. Calder. 2003. Differential effects of short-chain fatty acids on proliferation and production of pro-and anti-inflammatory cytokines by cultured lymphocytes. Life Sciences 73 (13):1683–90. doi: 10.1016/S0024-3205(03)00490-9.
   PubMed Web of Science ®Google Scholar
• Chen, T., D. Noto, Y. Hoshino, M. Mizuno, and S. Miyake. 2019. Butyrate suppresses demyelination and enhances remyelination. Journal of Neuroinflammation 16 (1):1–13. doi: 10.1186/s12974-019-1552-y.
   PubMed Web of Science ®Google Scholar
• Chevalier, A. C., and T. A. Rosenberger. 2017. Increasing acetyl-CoA metabolism attenuates injury and alters spinal cord lipid content in mice subjected to experimental autoimmune encephalomyelitis . J Neurochem 141 (5):721–37. doi: 10.1111/jnc.14032.
   PubMed Web of Science ®Google Scholar
• Cobbold, R., and P. Desmarchelier. 2004. In vitro studies on the colonization of bovine colonic mucosa by Shiga-toxigenic Escherichia coli (STEC). Epidemiology and Infection 132 (1):87–94. doi: 10.1017/s0950268803001432.
   PubMed Web of Science ®Google Scholar
• Conte, M., G. Petrone, A. Di Biase, M. Ammendolia, F. Superti, and L. Seganti. 2000. Acid tolerance in Listeria monocytogenes influences invasiveness of enterocyte-like cells and macrophage-like cells. Microbial Pathogenesis 29 (3):137–44. doi: 10.1006/mpat.2000.0379.
   PubMed Web of Science ®Google Scholar
• Conte, M. P., G. Petrone, A. M. Di Biase, C. Longhi, M. Penta, A. Tinari, F. Superti, G. Fabozzi, P. Visca, and L. Seganti. 2002. Effect of acid adaptation on the fate of Listeria monocytogenes in THP-1 human macrophages activated by gamma interferon. Infection and Immunity 70 (8):4369–78. doi: 10.1128/iai.70.8.4369-4378.2002.
   PubMed Web of Science ®Google Scholar
• Cotter, P. D., C. G. Gahan, and C. Hill. 2001. A glutamate decarboxylase system protects Listeria monocytogenes in gastric fluid. Molecular Microbiology 40 (2):465–75. doi: 10.1046/j.1365-2958.2001.02398.x.
   PubMed Web of Science ®Google Scholar
• Cotter, P. D., and C. Hill. 2003. Surviving the acid test: Responses of gram-positive bacteria to low pH. Microbiology and Molecular Biology Reviews : MMBR 67 (3):429–53. doi: 10.1128/mmbr.67.3.429-453.2003.
   PubMed Web of Science ®Google Scholar
• Cotter, P. D., S. Ryan, C. G. Gahan, and C. Hill. 2005. Presence of GadD1 glutamate decarboxylase in selected Listeria monocytogenes strains is associated with an ability to grow at low pH. Applied and Environmental Microbiology 71 (6):2832–9. doi: 10.1128/AEM.71.6.2832-2839.2005.
   PubMed Web of Science ®Google Scholar
• Cox, J., and A. Pavic. 2010. Advances in enteropathogen control in poultry production. Journal of Applied Microbiology 108 (3):745–55. doi: 10.1111/j.1365-2672.2009.04456.x.
   PubMed Web of Science ®Google Scholar
• Cronin, M., M. Ventura, G. F. Fitzgerald, and D. Van Sinderen. 2011. Progress in genomics, metabolism and biotechnology of bifidobacteria. International Journal of Food Microbiology 149 (1):4–18. doi: 10.1016/j.ijfoodmicro.2011.01.019.
   PubMed Web of Science ®Google Scholar
• Cryan, J. F., and T. G. Dinan. 2012. Mind-altering microorganisms: The impact of the gut microbiota on brain and behaviour. Nature Reviews. Neuroscience 13 (10):701–12. doi: 10.1038/nrn3346.
   PubMed Web of Science ®Google Scholar
• Davis, M. J., P. J. Coote, and C. P. O'Byrne. 1996. Acid tolerance in Listeria monocytogenes: The adaptive acid tolerance response (ATR) and growth-phase-dependent acid resistance. Microbiology 142 (10):2975–82. doi: 10.1099/13500872-142-10-2975.
   PubMedGoogle Scholar
• Defoirdt, T., N. Boon, P. Sorgeloos, W. Verstraete, and P. Bossier. 2009. Short-chain fatty acids and poly-beta-hydroxyalkanoates: (New) biocontrol agents for a sustainable animal production . Biotechnology Advances 27 (6):680–5. doi: 10.1016/j.biotechadv.2009.04.026.
   PubMed Web of Science ®Google Scholar
• Delgado-Vargas, F., A. Jiménez, and O. Paredes-López. 2000. Natural pigments: Carotenoids, anthocyanins, and betalains-characteristics, biosynthesis, processing, and stability. Critical Reviews in Food Science and Nutrition 40 (3):173–289. doi: 10.1080/10408690091189257.
   PubMed Web of Science ®Google Scholar
• Den Besten, G., K. van Eunen, A. K. Groen, K. Venema, D.-J. Reijngoud, and B. M. Bakker. 2013. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. Journal of Lipid Research 54 (9):2325–40. doi: 10.1194/jlr.R036012.
   PubMed Web of Science ®Google Scholar
• Deng, F.-L., J.-X. Pan, P. Zheng, J.-J. Xia, B.-M. Yin, W.-W. Liang, Y.-F. Li, J. Wu, F. Xu, Q.-Y. Wu, et al. 2019. Metabonomics reveals peripheral and central short-chain fatty acid and amino acid dysfunction in a naturally occurring depressive model of macaques. Neuropsychiatric Disease and Treatment 15:1077–88. doi: 10.2147/NDT.S186071.
   PubMed Web of Science ®Google Scholar
• Dewulf, E. M., P. D. Cani, A. M. Neyrinck, S. Possemiers, A. Van Holle, G. G. Muccioli, L. Deldicque, L. B. Bindels, B. D. Pachikian, F. M. Sohet, et al. 2011. Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice. The Journal of Nutritional Biochemistry 22 (8):712–22., doi: 10.1016/j.jnutbio.2010.05.009.
   PubMed Web of Science ®Google Scholar
• Díaz, I. B. Z., and S. C. Ricke. 2004. Influence of short chain fatty acids and lysine on Salmonella typhimurium cadA expression. Antonie Van Leeuwenhoek. 85 (1):45–51. doi: 10.1023/B:ANTO.0000020271.11533.71.
   PubMed Web of Science ®Google Scholar
• Durant, J. A., V. K. Lowry, D. J. Nisbet, L. H. Stanker, D. E. Corrier, and S. C. Ricke. 1999. Short-chain fatty acids affect cell-association and invasion of HEp-2 cells by Salmonella typhimurium . Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes 34 (6):1083–99. doi: 10.1080/03601239909373246.
   PubMed Web of Science ®Google Scholar
• El-Gedaily, A., G. Paesold, and M. Krause. 1997. Expression profile and subcellular location of the plasmid-encoded virulence (Spv) proteins in wild-type Salmonella dublin. Infection and Immunity 65 (8):3406–11. doi: 10.1128/IAI.65.8.3406-3411.1997.
   PubMed Web of Science ®Google Scholar
• Englyst, H. N., S. Kingman, and J. Cummings. 1992. Classification and measurement of nutritionally important starch fractions. European Journal of Clinical Nutrition 46:S33.
   PubMed Web of Science ®Google Scholar
• Fang, S., X. Chen, X. Ye, L. Zhou, S. Xue, and Q. Gan. 2020. Effects of gut microbiome and short-chain fatty acids (SCFAs) on finishing weight of meat rabbits. Frontiers in Microbiology 11:1835. doi: 10.3389/fmicb.2020.01835.
   PubMed Web of Science ®Google Scholar
• Fast, A. G., and E. T. Papoutsakis. 2012. Stoichiometric and energetic analyses of non-photosynthetic CO2-fixation pathways to support synthetic biology strategies for production of fuels and chemicals. Current Opinion in Chemical Engineering 1 (4):380–95. doi: 10.1016/j.coche.2012.07.005.
   Web of Science ®Google Scholar
• Fernández-Rubio, C., C. Ordonez, J. Abad-González, A. Garcia-Gallego, M. P. Honrubia, J. J. Mallo, and R. Balana-Fouce. 2009. Butyric acid-based feed additives help protect broiler chickens from Enteritidis infection. Poultry Science 88 (5):943–8. doi: 10.3382/ps.2008-00484.
   PubMed Web of Science ®Google Scholar
• Frozza, R. L., M. V. Lourenco, and F. G. De Felice. 2018. Challenges for Alzheimer's disease therapy: Insights from novel mechanisms beyond memory defects. Frontiers in Neuroscience 12:37 doi: 10.3389/fnins.2018.00037.
   PubMed Web of Science ®Google Scholar
• Fukuda, S., H. Toh, K. Hase, K. Oshima, Y. Nakanishi, K. Yoshimura, T. Tobe, J. M. Clarke, D. L. Topping, T. Suzuki, et al. 2011. Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature 469 (7331):543–7., doi: 10.1038/nature09646.
   PubMed Web of Science ®Google Scholar
• Galán, J. E. 2001. Salmonella interactions with host cells: Type III secretion at work. Annu Rev Cell Dev Biol 17:53–86. doi: 10.1146/annurev.cellbio.17.1.53.
   PubMed Web of Science ®Google Scholar
• Gallo, R. L., and L. V. Hooper. 2012. Epithelial antimicrobial defence of the skin and intestine. Nature Reviews. Immunology 12 (7):503–16. doi: 10.1038/nri3228.
   PubMed Web of Science ®Google Scholar
• Ganji‐Arjenaki, M., and M. Rafieian‐Kopaei. 2018. Probiotics are a good choice in remission of inflammatory bowel diseases: A meta analysis and systematic review. Journal of Cellular Physiology 233:2091–103.
   PubMed Web of Science ®Google Scholar
• Gantois, I., R. Ducatelle, F. Pasmans, F. Haesebrouck, I. Hautefort, A. Thompson, J. Hinton, and F. Van Immerseel. 2006. Butyrate specifically down-regulates Salmonella pathogenicity island 1 gene expression. Applied and Environmental Microbiology 72 (1):946–9. doi: 10.1128/AEM.72.1.946-949.2006.
   PubMed Web of Science ®Google Scholar
• Gibson, G. R., H. M. Probert, J. Van Loo, R. A. Rastall, and M. B. Roberfroid. 2004. Dietary modulation of the human colonic microbiota: Updating the concept of prebiotics. Nutrition Research Reviews 17 (2):259–75. doi: 10.1079/NRR200479.
   PubMed Web of Science ®Google Scholar
• Gong, H., J. Su, Y. Bai, L. Miao, K. Kim, Y. Yang, F. Liu, and S. Lu. 2009. Characterization of the expression of Salmonella Type III secretion system factor PrgI, SipA, SipB, SopE2, SpaO, and SptP in cultures and in mice. BMC Microbiology 9 (1):1–14. doi: 10.1186/1471-2180-9-73.
   Web of Science ®Google Scholar
• Haghikia, A., S. Jörg, A. Duscha, J. Berg, A. Manzel, A. Waschbisch, A. Hammer, D.-H. Lee, C. May, N. Wilck, et al. 2015. Dietary fatty acids directly impact central nervous system autoimmunity via the small intestine. Immunity 43 (4):817–29. doi: 10.1016/j.immuni.2015.09.007.
   PubMed Web of Science ®Google Scholar
• Halestrap, A. P., and M. C. Wilson. 2012. The monocarboxylate transporter family-role and regulation. IUBMB Life 64 (2):109–19. doi: 10.1002/iub.572.
   PubMed Web of Science ®Google Scholar
• Hallert, C., I. Björck, M. Nyman, A. Pousette, C. Grännö, and H. Svensson. 2003. Increasing fecal butyrate in ulcerative colitis patients by diet: Controlled pilot study. Inflammatory Bowel Diseases 9:116–21.
   PubMed Web of Science ®Google Scholar
• Hamer, M., G. O'Donovan, D. Stensel, and E. Stamatakis. 2017. Normal-weight central obesity and risk for mortality. Ann Intern Med 166 (12):917–8. doi: 10.7326/L17-0022.
   PubMed Web of Science ®Google Scholar
• Heres, L., B. Engel, H. Urlings, J. Wagenaar, and F. Van Knapen. 2004. Effect of acidified feed on susceptibility of broiler chickens to intestinal infection by Campylobacter and Salmonella. Veterinary Microbiology 99 (3/4):259–67. doi: 10.1016/j.vetmic.2003.12.008.
   PubMed Web of Science ®Google Scholar
• Heres, L., B. Engel, F. Van Knapen, J. A. Wagenaar, and B. A. Urlings. 2003. Effect of fermented feed on the susceptibility for Campylobacter jejuni colonisation in broiler chickens with and without concurrent inoculation of Salmonella enteritidis. International Journal of Food Microbiology 87 (1-2):75–86. doi: 10.1016/S0168-1605(03)00055-2.
   PubMed Web of Science ®Google Scholar
• Hermans, D., K. Van Deun, W. Messens, A. Martel, F. Van Immerseel, F. Haesebrouck, G. Rasschaert, M. Heyndrickx, and F. Pasmans. 2011. Campylobacter control in poultry by current intervention measures ineffective: Urgent need for intensified fundamental research. Veterinary Microbiology 152 (3/4):219–28. doi: 10.1016/j.vetmic.2011.03.010.
   PubMed Web of Science ®Google Scholar
• Herold, S., J. C. Paton, P. Srimanote, and A. W. Paton. 2009. Differential effects of short-chain fatty acids and iron on expression of iha in Shiga-toxigenic Escherichia coli. Microbiology (Reading, England) 155 (Pt 11):3554–63. doi: 10.1099/mic.0.029454-0.
   PubMedGoogle Scholar
• Hill, J. M., S. Bhattacharjee, A. I. Pogue, and W. J. Lukiw. 2014. The gastrointestinal tract microbiome and potential link to Alzheimer's disease. Frontiers in Neurology 5:43 doi: 10.3389/fneur.2014.00043.
   PubMed Web of Science ®Google Scholar
• Hinnebusch, B. F., S. Meng, J. T. Wu, S. Y. Archer, and R. A. Hodin. 2002. The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation. J Nutr 132 (5):1012–7. doi: 10.1093/jn/132.5.1012.
   PubMed Web of Science ®Google Scholar
• Ho, L., K. Ono, M. Tsuji, P. Mazzola, R. Singh, and G. M. Pasinetti. 2018. Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer's disease-type beta-amyloid neuropathological mechanisms. Expert Review of Neurotherapeutics 18 (1):83–90. doi: 10.1080/14737175.2018.1400909.
   PubMed Web of Science ®Google Scholar
• Hoffman, J. D., I. Parikh, S. J. Green, G. Chlipala, R. P. Mohney, M. Keaton, B. Bauer, A. Hartz, and A.-L. Lin. 2017. Age drives distortion of brain metabolic, vascular and cognitive functions, and the gut microbiome. Frontiers in Aging Neuroscience 9:1–14. doi: 10.3389/fnagi.2017.00298.
   PubMed Web of Science ®Google Scholar
• Holmes, E., J. V. Li, T. Athanasiou, H. Ashrafian, and J. K. Nicholson. 2011. Understanding the role of gut microbiome-host metabolic signal disruption in health and disease. Trends in Microbiology 19 (7):349–59. doi: 10.1016/j.tim.2011.05.006.
   PubMed Web of Science ®Google Scholar
• Hong, Y.-H., Y. Nishimura, D. Hishikawa, H. Tsuzuki, H. Miyahara, C. Gotoh, K.-C. Choi, D. D. Feng, C. Chen, H.-G. Lee, et al. 2005. Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43. Endocrinology 146 (12):5092–9. doi: 10.1210/en.2005-0545.
   PubMed Web of Science ®Google Scholar
• Hooper, L. V., T. Midtvedt, and J. I. Gordon. 2002. How host-microbial interactions shape the nutrient environment of the mammalian intestine. Annual Review of Nutrition 22:283–307. doi: 10.1146/annurev.nutr.22.011602.092259.
   PubMed Web of Science ®Google Scholar
• Horswill, A. R., and J. C. Escalante-Semerena. 1999. Salmonella typhimurium LT2 catabolizes propionate via the 2-methylcitric acid cycle. Journal of Bacteriology 181 (18):5615–23. doi: 10.1128/JB.181.18.5615-5623.1999.
   PubMed Web of Science ®Google Scholar
• Huang, Y., M. Suyemoto, C. D. Garner, K. M. Cicconi, and C. Altier. 2008. Formate acts as a diffusible signal to induce Salmonella invasion. Journal of Bacteriology 190 (12):4233–41. doi: 10.1128/JB.00205-08.
   PubMed Web of Science ®Google Scholar
• Hung, C. C., C. D. Garner, J. M. Slauch, Z. W. Dwyer, S. D. Lawhon, J. G. Frye, M. McClelland, B. M. Ahmer, and C. Altier. 2013. The intestinal fatty acid propionate inhibits Salmonella invasion through the post-translational control of HilD . Molecular Microbiology 87 (5):1045–60. doi: 10.1111/mmi.12149.
   PubMed Web of Science ®Google Scholar
• Immerseel, F. V., J. D. Buck, I. D. Smet, F. Pasmans, F. Haesebrouck, and R. Ducatelle. 2004. Interactions of Butyric acid- and acetic acid-treated Salmonella with chicken primary cecal epithelial cells in vitro. Avian Diseases 48 (2):384–91. doi: 10.1637/7094.
   PubMed Web of Science ®Google Scholar
• Islam, D., L. Bandholtz, J. Nilsson, H. Wigzell, B. Christensson, B. Agerberth, and G. H. Gudmundsson. 2001. Downregulation of bactericidal peptides in enteric infections: A novel immune escape mechanism with bacterial DNA as a potential regulator. Nature Medicine 7 (2):180–5. doi: 10.1038/84627.
   PubMed Web of Science ®Google Scholar
• Iwanaga, T., K. Takebe, I. Kato, S.-I. Karaki, and A. Kuwahara. 2006. Cellular expression of monocarboxylate transporters (MCT) in the digestive tract of the mouse, rat, and humans, with special reference to slc5a8. Biomedical Research 27 (5):243–54. doi: 10.2220/biomedres.27.243.
   Google Scholar
• Jangi, S., R. Gandhi, L. M. Cox, N. Li, F. von Glehn, R. Yan, B. Patel, M. A. Mazzola, S. Liu, B. L. Glanz, et al. 2016. Alterations of the human gut microbiome in multiple sclerosis. Nature Communications 7 (1):12015. doi: 10.1038/ncomms12015.
   PubMedGoogle Scholar
• Jones, F. 2011. A review of practical Salmonella control measures in animal feed. Journal of Applied Poultry Research 20 (1):102–13. doi: 10.3382/japr.2010-00281.
   Web of Science ®Google Scholar
• Joossens, M., G. Huys, M. Cnockaert, V. De Preter, K. Verbeke, P. Rutgeerts, P. Vandamme, and S. Vermeire. 2011. Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives. Gut 60 (5):631–7. doi: 10.1136/gut.2010.223263.
   PubMed Web of Science ®Google Scholar
• Kaczmarczyk, M. M., M. J. Miller, and G. G. Freund. 2012. The health benefits of dietary fiber: Beyond the usual suspects of type 2 diabetes mellitus, cardiovascular disease and colon cancer. Metabolism: clinical and Experimental 61 (8):1058–66. doi: 10.1016/j.metabol.2012.01.017.
   PubMed Web of Science ®Google Scholar
• Kida, Y., T. Shimizu, and K. Kuwano. 2006. Sodium butyrate up-regulates cathelicidin gene expression via activator protein-1 and histone acetylation at the promoter region in a human lung epithelial cell line, EBC-1. Molecular Immunology 43 (12):1972–81. doi: 10.1016/j.molimm.2005.11.014.
   PubMed Web of Science ®Google Scholar
• Kroll, R., and R. Patchett. 1992. Induced acid tolerance in Listeria monocytogenes. Letters in Applied Microbiology 14 (5):224–7. doi: 10.1111/j.1472-765X.1992.tb00691.x.
   Web of Science ®Google Scholar
• Lango-Scholey, L.,. A. O. Brachmann, H. B. Bode, and D. J. Clarke. 2013. The expression of stlA in Photorhabdus luminescens is controlled by nutrient limitation. PLOS One 8 (11):e82152 doi: 10.1371/journal.pone.0082152.
   PubMed Web of Science ®Google Scholar
• Larsen, N., F. K. Vogensen, F. W. Van Den Berg, D. S. Nielsen, A. S. Andreasen, B. K. Pedersen, W. A. Al-Soud, S. J. Sørensen, L. H. Hansen, and M. Jakobsen. 2010. Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLOS One 5 (2):e9085. doi: 10.1371/journal.pone.0009085.
   PubMed Web of Science ®Google Scholar
• Lawhon, S. D., R. Maurer, M. Suyemoto, and C. Altier. 2002. Intestinal short-chain fatty acids alter Salmonella typhimurium invasion gene expression and virulence through BarA/SirA . Mol Microbiol 46 (5):1451–64. doi: 10.1046/j.1365-2958.2002.03268.x.
   PubMed Web of Science ®Google Scholar
• Layden, B. T., A. R. Angueira, M. Brodsky, V. Durai, and W. L. Lowe. Jr, 2013. Short chain fatty acids and their receptors: New metabolic targets. Translational Research : The Journal of Laboratory and Clinical Medicine 161 (3):131–40. doi: 10.1016/j.trsl.2012.10.007.
   PubMed Web of Science ®Google Scholar
• Le Poul, E., C. Loison, S. Struyf, J.-Y. Springael, V. Lannoy, M.-E. Decobecq, S. Brezillon, V. Dupriez, G. Vassart, J. Van Damme, et al. 2003. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. The Journal of Biological Chemistry 278 (28):25481–9. doi: 10.1074/jbc.M301403200.
   PubMed Web of Science ®Google Scholar
• Li, L.,. J. He, X. Xin, M. Wang, J. Xu, and J. Zhang. 2018a. Enhanced bioproduction of short-chain fatty acids from waste activated sludge by potassium ferrate pretreatment. Chemical Engineering Journal 332:456–63. doi: 10.1016/j.cej.2017.09.103.
   Web of Science ®Google Scholar
• Li, M., B. C. A. M. van Esch, G. T. M. Wagenaar, J. Garssen, G. Folkerts, and P. A. J. Henricks. 2018b. Pro- and anti-inflammatory effects of short chain fatty acids on immune and endothelial cells. European Journal of Pharmacology 831:52–9. doi: 10.1016/j.ejphar.2018.05.003.
   PubMed Web of Science ®Google Scholar
• Lin, H. V., A. Frassetto, E. J. Kowalik, A. R. Nawrocki, M. M. Lu, J. R. Kosinski, J. A. Hubert, D. Szeto, X. Yao, G. Forrest, et al. 2012. Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms. PLOS One 7 (4):e35240 doi: 10.1371/journal.pone.0035240.
   PubMed Web of Science ®Google Scholar
• Looijer–Van Langen, M. A., and L. A. Dieleman. 2009. Prebiotics in chronic intestinal inflammation. Inflammatory Bowel Disease 15 (3):454–62. doi: 10.1002/ibd.20737.
   PubMed Web of Science ®Google Scholar
• Luethy, P. M., S. Huynh, D. A. Ribardo, S. E. Winter, C. T. Parker, and D. R. Hendrixson. 2017. Microbiota-derived short-chain fatty acids modulate expression of Campylobacter jejuni determinants required for commensalism and virulence. MBio 8 (3):1–26. doi: 10.1128/mBio.00407-17.
   Web of Science ®Google Scholar
• Luu, M., H. Monning, and A. Visekruna. 2020. Exploring the molecular mechanisms underlying the protective effects of microbial SCFAs on intestinal tolerance and food allergy. Frontiers in Immunology 11:1225. doi: 10.3389/fimmu.2020.01225.
   PubMed Web of Science ®Google Scholar
• Macfarlane, G., H. Steed, and S. Macfarlane. 2008. Bacterial metabolism and health-related effects of galacto-oligosaccharides and other prebiotics. Journal of Applied Microbiology 104 (2):305–44. doi: 10.1111/j.1365-2672.2007.03520.x.
   PubMed Web of Science ®Google Scholar
• Macfarlane, G. T., and S. Macfarlane. 2012. Bacteria, colonic fermentation, and gastrointestinal health. Journal of AOAC International 95 (1):50–60. doi: 10.5740/jaoacint.sge_macfarlane.
   PubMed Web of Science ®Google Scholar
• Macfarlane, S., and G. T. Macfarlane. 2003. Regulation of short-chain fatty acid production. The Proceedings of the Nutrition Society 62 (1):67–72. doi: 10.1079/PNS2002207.
   PubMed Web of Science ®Google Scholar
• Marette, A., and C. Jobin. 2015. SCFAs take a toll en route to metabolic syndrome. Cell Metabolism 22 (6):954–6. doi: 10.1016/j.cmet.2015.11.006.
   PubMed Web of Science ®Google Scholar
• Jayasimhan, A., and E. Mariño. 2019. Dietary SCFAs, IL-22, and GFAP: The three musketeers in the gut-neuro-immune network in Type 1 diabetes . Frontiers in Immunology 10:2429 doi: 10.3389/fimmu.2019.02429.
   PubMed Web of Science ®Google Scholar
• Marron, L., N. Emerson, C. Gahan, and C. Hill. 1997. A mutant of Listeria monocytogenes LO28 unable to induce an acid tolerance response displays diminished virulence in a murine model. Appl Environ Microbiol 63 (12):4945–7. doi: 10.1128/AEM.63.12.4945-4947.1997.
   PubMed Web of Science ®Google Scholar
• Maslowski, K. M., A. T. Vieira, A. Ng, J. Kranich, F. Sierro, D. Yu, H. C. Schilter, M. S. Rolph, F. Mackay, D. Artis, et al. 2009. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 461 (7268):1282–6., doi: 10.1038/nature08530.
   PubMed Web of Science ®Google Scholar
• McHan, F., and E. B. Shotts. 1992. Effect of feeding selected short-chain fatty acids on the in vivo attachment of Salmonella typhimurium in chick ceca. Avian Diseases 36 (1):139–42. doi: 10.2307/1591728.
   PubMed Web of Science ®Google Scholar
• McHan, F., and E. B. Shotts. 1993. Effect of short-chain fatty acids on the growth of Salmonella typhimurium in an in vitro system. Avian Diseases 37 (2):396–8. doi: 10.2307/1591664.
   PubMed Web of Science ®Google Scholar
• McNabney, S. M., and T. M. Henagan. 2017. Short chain fatty acids in the colon and peripheral tissues: A focus on butyrate, colon cancer, obesity and insulin resistance. Nutrients 9 (12):1348. doi: 10.3390/nu9121348.
   PubMed Web of Science ®Google Scholar
• Miller, A. H., and C. L. Raison. 2016. The role of inflammation in depression: From evolutionary imperative to modern treatment target. Nature Reviews. Immunology 16 (1):22–34. doi: 10.1038/nri.2015.5.
   PubMed Web of Science ®Google Scholar
• Miller, T. L., and M. J. Wolin. 1996. Pathways of acetate, propionate, and butyrate formation by the human fecal microbial flora. Applied and Environmental Microbiology 62 (5):1589–92. doi: 10.1128/AEM.62.5.1589-1592.1996.
   PubMed Web of Science ®Google Scholar
• Miyauchi, S., E. Gopal, Y.-J. Fei, and V. Ganapathy. 2004. Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids . The Journal of Biological Chemistry 279 (14):13293–6. doi: 10.1074/jbc.C400059200.
   PubMed Web of Science ®Google Scholar
• Nakamura, M., H. Saito, H. Ebinuma, K. Wakabayashi, Y. Saito, T. Takagi, N. Nakamoto, and H. Ishii. 2001. Reduction of telomerase activity in human liver cancer cells by a histone deacetylase inhibitor. Journal of Cellular Physiology 187 (3):392–401. doi: 10.1002/jcp.1087.
   PubMed Web of Science ®Google Scholar
• Nakanishi, N., K. Tashiro, S. Kuhara, T. Hayashi, N. Sugimoto, and T. Tobe. 2009. Regulation of virulence by butyrate sensing in enterohaemorrhagic Escherichia coli. Microbiology (Reading, England) 155 (Pt 2):521–30. doi: 10.1099/mic.0.023499-0.
   PubMedGoogle Scholar
• Newman, E., and R. Lin. 1995. Leucine-responsive regulatory protein: A global regulator of gene expression in E. coli. Annual Review of Microbiology 49:747–75. doi: 10.1146/annurev.mi.49.100195.003531.
   PubMed Web of Science ®Google Scholar
• Ni, Y.-F., J. Wang, X.-L. Yan, F. Tian, J.-B. Zhao, Y.-J. Wang, and T. Jiang. 2010. Histone deacetylase inhibitor, butyrate, attenuates lipopolysaccharide-induced acute lung injury in mice. Respiratory Research 11 (1):1–8. doi: 10.1186/1465-9921-11-33.
   PubMedGoogle Scholar
• Nicholson, J. K., E. Holmes, J. Kinross, R. Burcelin, G. Gibson, W. Jia, and S. Pettersson. 2012. Host-gut microbiota metabolic interactions. Science (New York, N.Y.) 336 (6086):1262–7. doi: 10.1126/science.1223813.
   PubMed Web of Science ®Google Scholar
• Nilsson, A., Y. Granfeldt, E. Östman, T. Preston, and I. Björck. 2006. Effects of GI and content of indigestible carbohydrates of cereal-based evening meals on glucose tolerance at a subsequent standardised breakfast. European Journal of Clinical Nutrition 60 (9):1092–9. doi: 10.1038/sj.ejcn.1602423.
   PubMed Web of Science ®Google Scholar
• O'Driscoll, B., C. Gahan, and C. Hill. 1996. Adaptive acid tolerance response in Listeria monocytogenes: Isolation of an acid-tolerant mutant which demonstrates increased virulence. Applied and Environmental Microbiology 62 (5):1693–8. doi: 10.1128/AEM.62.5.1693-1698.1996.
   PubMed Web of Science ®Google Scholar
• Pan, X-d., F-q. Chen, T-x. Wu, H-g. Tang, and Z-y. Zhao. 2009. Prebiotic oligosaccharides change the concentrations of short-chain fatty acids and the microbial population of mouse bowel. Journal of Zhejiang University SCIENCE B 10 (4):258–63. doi: 10.1631/jzus.B0820261.
   PubMed Web of Science ®Google Scholar
• Parada Venegas, D., M. K. De la Fuente, G. Landskron, M. J. González, R. Quera, G. Dijkstra, H. J. Harmsen, K. N. Faber, and M. A. Hermoso. 2019. Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases. Frontiers in Immunology 10:1486. doi: 10.3389/fimmu.2019.01486.
   PubMed Web of Science ®Google Scholar
• Pekmez, C. T., L. O. Dragsted, and L. K. Brahe. 2019. Gut microbiota alterations and dietary modulation in childhood malnutrition - The role of short chain fatty acids. Clinical Nutrition (Edinburgh, Scotland) 38 (2):615–30. doi: 10.1016/j.clnu.2018.02.014.29496274.
   PubMed Web of Science ®Google Scholar
• Pokusaeva, K., G. F. Fitzgerald, and D. van Sinderen. 2011. Carbohydrate metabolism in Bifidobacteria. Genes & Nutrition 6 (3):285–306. doi: 10.1007/s12263-010-0206-6.
   PubMed Web of Science ®Google Scholar
• Postler, T. S., and S. Ghosh. 2017. Understanding the holobiont: How microbial metabolites affect human health and shape the immune system. Cell Metabolism 26 (1):110–30. doi: 10.1016/j.cmet.2017.05.008.
   PubMed Web of Science ®Google Scholar
• Pourabedin, M., and X. Zhao. 2015. Prebiotics and gut microbiota in chickens. FEMS Microbiology Letters 362 (15):fnv122 doi: 10.1093/femsle/fnv122.
   PubMed Web of Science ®Google Scholar
• Puddu, A., R. Sanguineti, F. Montecucco, and G. L. Viviani. 2014. Evidence for the gut microbiota short-chain fatty acids as key pathophysiological molecules improving diabetes. Mediators of Inflammation 2014:162021. doi: 10.1155/2014/162021.
   PubMed Web of Science ®Google Scholar
• Puertollano, E., S. Kolida, and P. Yaqoob. 2014. Biological significance of short-chain fatty acid metabolism by the intestinal microbiome. Current Opinion in Clinical Nutrition & Metabolic Care 17 (2):139–144. doi: 10.1097/MCO.0000000000000025.
   PubMed Web of Science ®Google Scholar
• Putignani, L., F. Del Chierico, P. Vernocchi, M. Cicala, S. Cucchiara, B. Dallapiccola, and Dysbiotrack Study Group. 2016. Gut microbiota dysbiosis as risk and premorbid factors of IBD and IBS along the Childhood-Adulthood Transition. Inflamm Bowel Dis 22 (2):487–504. doi: 10.1097/MIB.0000000000000602.
   PubMed Web of Science ®Google Scholar
• Rabbani, G., M. J. Albert, A. H. Rahman, M. M. Isalm, K. N. Islam, and K. Alam. 1999. Short-chain fatty acids improve clinical, pathologic, and microbiologic features of experimental shigellosis. The Journal of Infectious Diseases 179 (2):390–7. doi: 10.1086/314584.
   PubMed Web of Science ®Google Scholar
• Raqib, R.,. P. Sarker, P. Bergman, G. Ara, M. Lindh, D. A. Sack, K. N. Islam, G. H. Gudmundsson, J. Andersson, and B. Agerberth. 2006. Improved outcome in shigellosis associated with butyrate induction of an endogenous peptide antibiotic. Proceedings of the National Academy of Sciences of the United States of America 103 (24):9178–83. doi: 10.1073/pnas.0602888103.
   PubMed Web of Science ®Google Scholar
• Raqib, R.,. P. Sarker, A. Mily, N. H. Alam, A. S. M. Arifuzzaman, R. S. Rekha, J. Andersson, G. H. Gudmundsson, A. Cravioto, and B. Agerberth. 2012. Efficacy of sodium butyrate adjunct therapy in shigellosis: A randomized, double-blind, placebo-controlled clinical trial. BMC Infectious Diseases 12 (1):1–11. doi: 10.1186/1471-2334-12-111.
   PubMedGoogle Scholar
• Rasmussen, H. E., and B. R. Hamaker. 2017. Prebiotics and inflammatory bowel disease. Gastroenterology Clinics of North America 46 (4):783–95. doi: 10.1016/j.gtc.2017.08.004.
   PubMed Web of Science ®Google Scholar
• Ratajczak, W., A. Rył, A. Mizerski, K. Walczakiewicz, O. Sipak, and M. Laszczyńska. 2019. Immunomodulatory potential of gut microbiome-derived short-chain fatty acids (SCFAs). Acta Biochimica Polonica 66 (1):1–12. doi: 10.18388/abp.2018_2648.
   PubMed Web of Science ®Google Scholar
• Rey, F. E., J. J. Faith, J. Bain, M. J. Muehlbauer, R. D. Stevens, C. B. Newgard, and J. I. Gordon. 2010. Dissecting the in vivo metabolic potential of two human gut acetogens. The Journal of Biological Chemistry 285 (29):22082–90. doi: 10.1074/jbc.M110.117713.
   PubMed Web of Science ®Google Scholar
• Ricke, S. 2003. Perspectives on the use of organic acids and short chain fatty acids as antimicrobials. Poultry Science 82 (4):632–9. doi: 10.1093/ps/82.4.632.
   PubMed Web of Science ®Google Scholar
• Ryan, S., C. Hill, and C. Gahan. 2008. Acid stress responses in Listeria monocytogenes. Advances in Applied Microbiology 65:67–91. doi: 10.1016/S0065-2164(08)00603-5.
   PubMed Web of Science ®Google Scholar
• Säemann, M. D., G. A. Böhmig, C. H. Österreicher, H. Burtscher, O. Parolini, C. Diakos, J. Stöckl, W. H. Hörl, and G. J. Zlabinger. 2000. Anti-inflammatory effects of sodium butyrate on human monocytes: potent inhibition of IL-12 and up-regulation of IL-10 production . FASEB Journal : official Publication of the Federation of American Societies for Experimental Biology 14 (15):2380–2. doi: 10.1096/fj.00-0359fje.
   PubMed Web of Science ®Google Scholar
• Sanna, S.,. N. R. van Zuydam, A. Mahajan, A. Kurilshikov, A. Vich Vila, U. Võsa, Z. Mujagic, A. A. M. Masclee, D. M. A. E. Jonkers, M. Oosting, et al. 2019. Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases. Nature Genetics 51 (4):600–5., doi: 10.1038/s41588-019-0350-x.
   PubMed Web of Science ®Google Scholar
• Sasaki, D., K. Sasaki, N. Ikuta, T. Yasuda, I. Fukuda, A. Kondo, and R. Osawa. 2018. Low amounts of dietary fibre increase in vitro production of short-chain fatty acids without changing human colonic microbiota structure. Scientific Reports 8 (1):9. doi: 10.1038/s41598-017-18877-8.
   PubMedGoogle Scholar
• Schloissnig, S.,. M. Arumugam, S. Sunagawa, M. Mitreva, J. Tap, A. Zhu, A. Waller, D. R. Mende, J. R. Kultima, J. Martin, et al. 2013. Genomic variation landscape of the human gut microbiome. Nature 493 (7430):45–50., doi: 10.1038/nature11711.
   PubMed Web of Science ®Google Scholar
• Segain, J. P., D. Raingeard de la Blétière, A. Bourreille, V. Leray, N. Gervois, C. Rosales, L. Ferrier, C. Bonnet, H. M. Blottière, and J. P. Galmiche. 2000. Butyrate inhibits inflammatory responses through NFkappaB inhibition: Implications for Crohn's disease. Gut 47 (3):397–403. doi: 10.1136/gut.47.3.397.
   PubMed Web of Science ®Google Scholar
• Shabala, L., T. Ross, T. McMeekin, and S. Shabala. 2006. Non-invasive microelectrode ion flux measurements to study adaptive responses of microorganisms to the environment. FEMS Microbiology Reviews 30 (3):472–86. doi: 10.1111/j.1574-6976.2006.00019.x.
   PubMed Web of Science ®Google Scholar
• Singh, N., M. Thangaraju, P. D. Prasad, P. M. Martin, N. A. Lambert, T. Boettger, S. Offermanns, and V. Ganapathy. 2010. Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases. The Journal of Biological Chemistry 285 (36):27601–8. doi: 10.1074/jbc.M110.102947.
   PubMed Web of Science ®Google Scholar
• Skonieczna-Żydecka, K., W. Marlicz, A. Misera, A. Koulaouzidis, and I. Łoniewski. 2018. Microbiome—the missing link in the gut-brain axis: Focus on its role in gastrointestinal and mental health. Journal of Clinical Medicine 7 (12):521. doi: 10.3390/jcm7120521.
   Web of Science ®Google Scholar
• Stanisavljević, S.,. A. Čepić, S. Bojić, K. Veljović, S. Mihajlović, N. Đedović, B. Jevtić, M. Momčilović, M. Lazarević, M. Mostarica Stojković, et al. 2019. Oral neonatal antibiotic treatment perturbs gut microbiota and aggravates central nervous system autoimmunity in Dark Agouti rats. Scientific Reports 9 (1):13. doi: 10.1038/s41598-018-37505-7.
   PubMedGoogle Scholar
• Sun, J., and N. J. Buys. 2016. Glucose- and glycaemic factor-lowering effects of probiotics on diabetes: a meta-analysis of randomised placebo-controlled trials . The British Journal of Nutrition 115 (7):1167–77. doi: 10.1017/S0007114516000076.
   PubMed Web of Science ®Google Scholar
• Sun, J., J. Xu, Y. Ling, F. Wang, T. Gong, C. Yang, S. Ye, K. Ye, D. Wei, Z. Song, et al. 2019. Fecal microbiota transplantation alleviated Alzheimer’s disease-like pathogenesis in APP/PS1 transgenic mice. Translational Psychiatry 9 (1):13. doi: 10.1038/s41398-019-0525-3.
   PubMedGoogle Scholar
• Sun, Y., B. J. Wilkinson, T. J. Standiford, H. T. Akinbi, and M. X. O'Riordan. 2012. Fatty acids regulate stress resistance and virulence factor production for Listeria monocytogenes. Journal of Bacteriology 194 (19):5274–84. doi: 10.1128/JB.00045-12.
   PubMed Web of Science ®Google Scholar
• Sunkara, L. T., M. Achanta, N. B. Schreiber, Y. R. Bommineni, G. Dai, W. Jiang, S. Lamont, H. S. Lillehoj, A. Beker, R. G. Teeter, et al. 2011. Butyrate enhances disease resistance of chickens by inducing antimicrobial host defense peptide gene expression. PLOS One 6 (11):e27225 doi: 10.1371/journal.pone.0027225.
   PubMed Web of Science ®Google Scholar
• Sunkara, L. T., W. Jiang, and G. Zhang. 2012. Modulation of antimicrobial host defense peptide gene expression by free fatty acids. PLOS One 7 (11):e49558. doi: 10.1371/journal.pone.0049558.
   PubMed Web of Science ®Google Scholar
• Swennen, K., C. M. Courtin, and J. A. Delcour. 2006. Non-digestible oligosaccharides with prebiotic properties. Crit Rev Food Sci Nutr 46 (6):459–71. doi: 10.1080/10408390500215746.
   PubMed Web of Science ®Google Scholar
• Szczesniak, R. D., D. Li, L. L. Duan, M. Altaye, M. Miodovnik, and J. C. Khoury. 2016. Longitudinal patterns of glycemic control and blood pressure in pregnant women with type 1 diabetes mellitus: Phenotypes from functional data analysis. American Journal of Perinatology 33 (13):1282–90. doi: 10.1055/s-0036-1586507.
   PubMed Web of Science ®Google Scholar
• Tazoe, H., Y. Otomo, I. Kaji, R. Tanaka, S. Karaki, and A. Kuwahara. 2008. Roles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions. Journal of Physiology and Pharmacology 59:251–62.
   PubMed Web of Science ®Google Scholar
• Tedelind, S., F. Westberg, M. Kjerrulf, and A. Vidal. 2007. Anti-inflammatory properties of the short-chain fatty acids acetate and propionate: a study with relevance to inflammatory bowel disease. World Journal of Gastroenterology 13 (20):2826–32. doi: 10.3748/wjg.v13.i20.2826.
   PubMed Web of Science ®Google Scholar
• Termén, S., M. Tollin, E. Rodriguez, S. H. Sveinsdóttir, B. Jóhannesson, A. Cederlund, J. Sjövall, B. Agerberth, and G. H. Gudmundsson. 2008. PU.1 and bacterial metabolites regulate the human gene CAMP encoding antimicrobial peptide LL-37 in colon epithelial cells. Molecular Immunology 45 (15):3947–55. doi: 10.1016/j.molimm.2008.06.020.
   PubMed Web of Science ®Google Scholar
• Thangaraju, M., G. A. Cresci, K. Liu, S. Ananth, J. P. Gnanaprakasam, D. D. Browning, J. D. Mellinger, S. B. Smith, G. J. Digby, N. A. Lambert, et al. 2009. GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon. Cancer Research 69 (7):2826–32., doi: 10.1158/0008-5472.CAN-08-4466.
   PubMed Web of Science ®Google Scholar
• Tian, Y., Q. Xu, L. Sun, Y. Ye, and G. Ji. 2018. Short-chain fatty acids administration is protective in colitis-associated colorectal cancer development. The Journal of Nutritional Biochemistry 57:103–9. doi: 10.1016/j.jnutbio.2018.03.007.
   PubMed Web of Science ®Google Scholar
• Tobe, T.,. N. Nakanishi, and N. Sugimoto. 2011. Activation of motility by sensing short-chain fatty acids via two steps in a flagellar gene regulatory cascade in enterohemorrhagic Escherichia coli. Infection and Immunity 79 (3):1016–24. doi: 10.1128/IAI.00927-10.
   PubMed Web of Science ®Google Scholar
• Tolhurst, G., H. Heffron, Y. S. Lam, H. E. Parker, A. M. Habib, E. Diakogiannaki, J. Cameron, J. Grosse, F. Reimann, and F. M. Gribble. 2012. Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2. Diabetes 61 (2):364–71. doi: 10.2337/db11-1019.
   PubMed Web of Science ®Google Scholar
• Torres-Fuentes, C., A. V. Golubeva, A. V. Zhdanov, S. Wallace, S. Arboleya, D. B. Papkovsky, S. El Aidy, P. Ross, B. L. Roy, C. Stanton, et al. 2019. Short-chain fatty acids and microbiota metabolites attenuate ghrelin receptor signaling . FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology 33 (12):13546–59., doi: 10.1096/fj.201901433R.
   PubMed Web of Science ®Google Scholar
• van de Wouw, M., M. Boehme, J. M. Lyte, N. Wiley, C. Strain, O. O'Sullivan, G. Clarke, C. Stanton, T. G. Dinan, and J. F. Cryan. 2018. Short-chain fatty acids: microbial metabolites that alleviate stress-induced brain-gut axis alterations . The Journal of Physiology 596 (20):4923–44. doi: 10.1113/JP276431.
   PubMed Web of Science ®Google Scholar
• van der Beek, C. M., C. H. Dejong, F. J. Troost, A. A. Masclee, and K. Lenaerts. 2017. Role of short-chain fatty acids in colonic inflammation, carcinogenesis, and mucosal protection and healing. Nutrition Reviews 75 (4):286–305. doi: 10.1093/nutrit/nuw067.
   PubMed Web of Science ®Google Scholar
• Van Deun, K., F. Pasmans, F. Van Immerseel, R. Ducatelle, and F. Haesebrouck. 2008. Butyrate protects Caco-2 cells from Campylobacter jejuni invasion and translocation. The British Journal of Nutrition 100 (3):480–4. doi: 10.1017/S0007114508921693.
   PubMed Web of Science ®Google Scholar
• Van Immerseel, F., J. De Buck, F. Pasmans, P. Velge, E. Bottreau, V. Fievez, F. Haesebrouck, and R. Ducatelle. 2003. Invasion of Salmonella enteritidis in avian intestinal epithelial cells in vitro is influenced by short-chain fatty acids. International Journal of Food Microbiology 85 (3):237–48. doi: 10.1016/S0168-1605(02)00542-1.
   PubMed Web of Science ®Google Scholar
• Vinolo, M., H. Rodrigues, R. Nachbar, and R. Curi. 2011. Regulation of inflammation by short chain fatty acids. Nutrients 3 (10):858–76. doi: 10.3390/nu3100858.
   PubMed Web of Science ®Google Scholar
• Vinolo, M. A., H. G. Rodrigues, E. Hatanaka, C. B. Hebeda, S. H. Farsky, and R. Curi. 2009. Short-chain fatty acids stimulate the migration of neutrophils to inflammatory sites. Clinical Science (London, England : 1979) 117 (9):331–8. doi: 10.1042/CS20080642.
   PubMed Web of Science ®Google Scholar
• Wakabayashi, T., and W. Kratschmer. 2005. Carbon chain molecules cryogenic matrices. In Polyynes: Synthesis, Properties, and Applications, ed. F. Cataldo, 1–14. 1st ed. Boca Raton: CRC Press.
   Google Scholar
• Wales, A. D., V. M. Allen, and R. H. Davies. 2010. Chemical treatment of animal feed and water for the control of Salmonella. Foodborne Pathogens and Disease 7 (1):3–15. doi: 10.1089/fpd.2009.0373.
   PubMed Web of Science ®Google Scholar
• Walsh, M. E., A. Bhattacharya, K. Sataranatarajan, R. Qaisar, L. Sloane, M. M. Rahman, M. Kinter, and H. Van Remmen. 2015. The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging. Aging Cell 14 (6):957–70. doi: 10.1111/acel.12387.
   PubMed Web of Science ®Google Scholar
• Wang, L., C. T. Christophersen, M. J. Sorich, J. P. Gerber, M. T. Angley, and M. A. Conlon. 2012. Elevated fecal short chain fatty acid and ammonia concentrations in children with autism spectrum disorder. Digestive Diseases and Sciences 57 (8):2096–102. doi: 10.1007/s10620-012-2167-7.
   PubMed Web of Science ®Google Scholar
• Wéra, O., P. Lancellotti, and C. Oury. 2016. The dual role of neutrophils in inflammatory bowel diseases. Journal of Clinical Medicine 5 (12):118. doi: 10.3390/jcm5120118.
   Web of Science ®Google Scholar
• Wolever, T. M., D. J. Jenkins, A. L. Jenkins, and R. G. Josse. 1991. The glycemic index: Methodology and clinical implications. The American Journal of Clinical Nutrition 54 (5):846–54. doi: 10.1093/ajcn/54.5.846.
   PubMed Web of Science ®Google Scholar
• Wong, A. R., J. S. Pearson, M. D. Bright, D. Munera, K. S. Robinson, S. F. Lee, G. Frankel, and E. L. Hartland. 2011. Enteropathogenic and enterohaemorrhagic Escherichia coli: Even more subversive elements. Molecular Microbiology 80 (6):1420–38. doi: 10.1111/j.1365-2958.2011.07661.x.
   PubMed Web of Science ®Google Scholar
• Wong, J. M., R. De Souza, C. W. Kendall, A. Emam, and D. J. Jenkins. 2006. Colonic health: Fermentation and short chain fatty acids. Journal of Clinical Gastroenterology 40 (3):235–43. doi: 10.1097/00004836-200603000-00015.
   PubMed Web of Science ®Google Scholar
• Xiong, Y., N. Miyamoto, K. Shibata, M. A. Valasek, T. Motoike, R. M. Kedzierski, and M. Yanagisawa. 2004. Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proceedings of the National Academy of Sciences of the United States of America 101 (4):1045–50. doi: 10.1073/pnas.2637002100.
   PubMed Web of Science ®Google Scholar
• Yadav, H., J.-H. Lee, J. Lloyd, P. Walter, and S. G. Rane. 2013. Beneficial metabolic effects of a probiotic via butyrate-induced GLP-1 hormone secretion. The Journal of Biological Chemistry 288 (35):25088–97. doi: 10.1074/jbc.M113.452516.
   PubMed Web of Science ®Google Scholar
• Yokoyama, K., S. A. Ishijima, L. Clowney, H. Koike, H. Aramaki, C. Tanaka, K. Makino, and M. Suzuki. 2006. Feast/famine regulatory proteins (FFRPs): Escherichia coli Lrp, AsnC and related archaeal transcription factors. FEMS Microbiology Reviews 30 (1):89–108. doi: 10.1111/j.1574-6976.2005.00005.x.
   PubMed Web of Science ®Google Scholar
• Zhang, L., Y. Wang, X. Xiayu, C. Shi, W. Chen, N. Song, X. Fu, R. Zhou, Y.-F. Xu, L. Huang, et al. 2017. Altered gut microbiota in a mouse model of Alzheimer's Disease. Journal of Alzheimer's Disease : JAD 60 (4):1241–57., doi: 10.3233/JAD-170020.
   PubMed Web of Science ®Google Scholar
• Zhang, X., Y. Zhao, J. Xu, Z. Xue, M. Zhang, X. Pang, X. Zhang, and L. Zhao. 2015. Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats. Scientific Reports 5:14405 doi: 10.1038/srep14405.
   PubMed Web of Science ®Google Scholar
• Zheng, J., S.-J. Zheng, W.-J. Cai, L. Yu, B.-F. Yuan, and Y.-Q. Feng. 2019. Stable isotope labeling combined with liquid chromatography-tandem mass spectrometry for comprehensive analysis of short-chain fatty acids. Analytica Chimica Acta 1070:51–9. doi: 10.1016/j.aca.2019.04.021.
   PubMed Web of Science ®Google Scholar
• Zheng, L., C. J. Kelly, K. D. Battista, R. Schaefer, J. M. Lanis, E. E. Alexeev, R. X. Wang, J. C. Onyiah, D. J. Kominsky, and S. P. Colgan. 2017. Microbial-derived butyrate promotes epithelial barrier function through IL-10 Receptor-Dependent Repression of Claudin-2. J Immunol 199 (8):2976–84. doi: 10.4049/jimmunol.1700105.
   PubMed Web of Science ®Google Scholar
• Zheng, N., Y. Gao, W. Zhu, D. Meng, and W. A. Walker. 2020. Short chain fatty acids produced by colonizing intestinal commensal bacterial interaction with expressed breast milk are anti-inflammatory in human immature enterocytes. PLOS One 15 (2):e0229283 doi: 10.1371/journal.pone.0229283.
   PubMed Web of Science ®Google Scholar
• Zimmerman, M. A., N. Singh, P. M. Martin, M. Thangaraju, V. Ganapathy, J. L. Waller, H. Shi, K. D. Robertson, D. H. Munn, and K. Liu. 2012. Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells. Am J Physiol Gastrointest Liver Physiol 302 (12):G1405–G1415. doi: 10.1152/ajpgi.00543.2011.
   PubMed Web of Science ®Google Scholar
• Zoetendal, E. G., J. Raes, B. Van Den Bogert, M. Arumugam, C. C. Booijink, F. J. Troost, P. Bork, M. Wels, W. M. De Vos, and M. Kleerebezem. 2012. The human small intestinal microbiota is driven by rapid uptake and conversion of simple carbohydrates. The ISME Journal 6 (7):1415–26. doi: 10.1038/ismej.2011.212.
   PubMed Web of Science ®Google Scholar