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Anthocyanin supplement as a dietary strategy in cancer prevention and management: A comprehensive review

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References

  • Amararathna, M., D. W. Hoskin, and H. V. Rupasinghe. 2020. Anthocyanin-rich haskap (Lonicera caerulea L.) berry extracts reduce nitrosamine-induced DNA damage in human normal lung epithelial cells in vitro. Food and Chemical Toxicology 141:111404.
  • Amatori, S., L. Mazzoni, J. M. Alvarez-Suarez, F. Giampieri, M. Gasparrini, T. Y. Forbes-Hernandez, S. Afrin, A. E. Provenzano, G. Persico, B. Mezzetti, et al. 2016. Polyphenol-rich strawberry extract (PRSE) shows in vitro and in vivo biological activity against invasive breast cancer cells. Scientific Reports 6 (1):30917. doi: 10.1038/srep30917.
  • Baby, B., P. Antony, and R. Vijayan. 2018. Antioxidant and anticancer properties of berries. Critical Reviews in Food Science and Nutrition 58 (15):2491–507. doi: 10.1080/10408398.2017.1329198.
  • Bishayee, A., T. Mbimba, R. J. Thoppil, E. H. Radnai, P. Sipos, S. Darvesh, H. G. Folkesson, and J. Hohmann. 2011. Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats. The Journal of Nutritional Biochemistry 22 (11):1035–46. doi: 10.1016/j.jnutbio.2010.09.001.
  • Bray, F., J. Ferlay, I. Soerjomataram, R. L. Siegel, L. A. Torre, and A. Jemal. 2018. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians 68 (6):394–424. doi: 10.3322/caac.21492.
  • Burton, L. J., M. Rivera, O. Hawsawi, J. Zou, T. Hudson, G. Wang, Q. Zhang, L. Cubano, N. Boukli, and V. Odero-Marah. 2016. Muscadine grape skin extract induces an unfolded protein response-mediated autophagy in prostate cancer cells: A TMT-based quantitative proteomic analysis. PLoS One 11 (10):e0164115. doi: 10.1371/journal.pone.0164115.
  • Cao, S. Y., Y. Li, X. Meng, C. N. Zhao, S. Li, R. Y. Gan, and H. B. Li. 2019. Dietary natural products and lung cancer: Effects and mechanisms of action. Journal of Functional Foods 52:316–31. doi: 10.1016/j.jff.2018.11.004.
  • Cao, H., O. Saroglu, A. Karadag, Z. Diaconeasa, G. Zoccatelli, C. A. Conte‐Junior, J. Y. Ou, W. B. Bai, C. M. Zamarioli, L. A. P. Freitas, et al. 2021. Available technologies on improving the stability of polyphenols in food processing. Food Frontiers 2:1–31.
  • Charepalli, V., L. Reddivari, S. Radhakrishnan, R. Vadde, R. Agarwal, and J. K. Vanamala. 2015. Anthocyanin-containing purple-fleshed potatoes suppress colon tumorigenesis via elimination of colon cancer stem cells. The Journal of Nutritional Biochemistry 26 (12):1641–9. doi: 10.1016/j.jnutbio.2015.08.005.
  • Chen, J., M. Jayachandran, B. Xu, and Z. Yu. 2019. Sea bass (Lateolabrax maculatus) accelerates wound healing: A transition from inflammation to proliferation. Journal of Ethnopharmacology 236:263–76. doi: 10.1016/j.jep.2019.03.012.
  • Chen, L. L., B. Jiang, C. G. Zhong, J. Guo, L. Zhang, T. Mu, Q. H. Zhang, and X. L. Bi. 2018. Chemoprevention of colorectal cancer by black raspberry anthocyanins involved the modulation of gut microbiota and SFRP2 demethylation. Carcinogenesis 39 (3):471–81. doi: 10.1093/carcin/bgy009.
  • Diaconeasa, Z. M., A. D. Frond, I. Ştirbu, D. Rugina, and C. Socaciu. 2018. Anthocyanins-smart Molecules for Cancer Prevention, 75. BoD–Books on Demand. London, UK: InTech Open Access Publisher.
  • Eskra, J. N., M. J. Schlicht, and M. C. Bosland. 2019. Effects of black raspberries and their ellagic acid and anthocyanin constituents on taxane chemotherapy of castration-resistant prostate cancer cells. Scientific Reports 9 (1):1–12. doi: 10.1038/s41598-019-39589-1.
  • Farrukh, A., J. Jeyaprakash, K. Hina, M. Radha, S. Inderpal, and G. Ramesh. 2016. Lung cancer inhibitory activity of dietary berries and berry polyphenolics. Journal of Berry Research 6 (2):105–14.
  • Fernández, J., L. García, J. Monte, C. J. Villar, and F. Lombó. 2018. Functional anthocyanin-rich sausages diminish colorectal cancer in an animal model and reduce pro-inflammatory bacteria in the intestinal microbiota. Genes 9 (3):133. doi: 10.3390/genes9030133.
  • Forbes-Hernández, T. Y. 2020. Berries polyphenols: Nano-delivery systems to improve their potential in cancer therapy. Journal of Berry Research 10 (1):45–60. doi: 10.3233/JBR-200547.
  • Fragoso, M. F., G. R. Romualdo, L. A. Vanderveer, J. Franco-Barraza, E. Cukierman, M. L. Clapper, R. F. Carvalho, and L. F. Barbisan. 2018. Lyophilized açaí pulp (Euterpe oleracea Mart) attenuates colitis-associated colon carcinogenesis while its main anthocyanin has the potential to affect the motility of colon cancer cells. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 121:237–45. doi: 10.1016/j.fct.2018.08.078.
  • Giampieri, F., M. Gasparrini, T. Y. Forbes-Hernandez, L. Mazzoni, F. Capocasa, S. Sabbadini, J. M. Alvarez-Suarez, S. Afrin, C. Rosati, T. Pandolfini, et al. 2018. Overexpression of the anthocyanidin synthase gene in strawberry enhances antioxidant capacity and cytotoxic effects on human hepatic cancer cells. Journal of Agricultural and Food Chemistry 66 (3):581–92. doi: 10.1021/acs.jafc.7b04177.
  • Grimes, K. L., C. M. Stuart, J. J. McCarthy, B. Kaur, E. J. Cantu, and S. C. Forester. 2018. Enhancing the cancer cell growth inhibitory effects of table grape anthocyanins. Journal of Food Science 83 (9):2369–74. doi: 10.1111/1750-3841.14294.
  • Ha, U., W. J. Bae, S. J. Kim, B. I. Yoon, S. H. Hong, J. Y. Lee, T. K. Hwang, S. Y. Hwang, Z. P. Wang, and S. W. Kim. 2015. Anthocyanin induces apoptosis of DU-145 cells in vitro and inhibits xenograft growth of prostate cancer. Yonsei Medical Journal 56 (1):16–23. doi: 10.3349/ymj.2015.56.1.16.
  • Han, F., P. Yang, H. Wang, I. Fernandes, N. Mateus, and Y. Liu. 2019. Digestion and absorption of red grape and wine anthocyanins through the gastrointestinal tract. Trends in Food Science & Technology 83:211–24. doi: 10.1016/j.tifs.2018.11.025.
  • He, B., J. Ge, P. Yue, X. Yue, R. Fu, J. Liang, and X. Gao. 2017. Loading of anthocyanins on chitosan nanoparticles influences anthocyanin degradation in gastrointestinal fluids and stability in a beverage. Food Chemistry 221:1671–7. doi: 10.1016/j.foodchem.2016.10.120.
  • Herrera-Sotero, M. Y., C. D. Cruz-Hernández, R. M. Oliart-Ros, J. L. Chávez-Servia, R. I. Guzmán-Gerónimo, V. González-Covarrubias, M. Cruz-Burgos, and M. Rodríguez-Dorantes. 2020. Anthocyanins of blue corn and tortilla arrest cell cycle and induce apoptosis on breast and prostate cancer cells. Nutrition and Cancer 72 (5):768–77. doi: 10.1080/01635581.2019.1654529.
  • Huang, H. P., Y. C. Chang, C. H. Wu, C. N. Hung, and C. J. Wang. 2011. Anthocyanin-rich mulberry extract inhibit the gastric cancer cell growth in vitro and xenograft mice by inducing signals of p38/p53 and c-jun. Food Chemistry 129 (4):1703–9. doi: 10.1016/j.foodchem.2011.06.035.
  • Jia, N., Y. L. Xiong, B. Kong, Q. Liu, and X. Xia. 2012. Radical scavenging activity of black currant (Ribes nigrum L.) extract and its inhibitory effect on gastric cancer cell proliferation via induction of apoptosis. Journal of Functional Foods 4 (1):382–90. doi: 10.1016/j.jff.2012.01.009.
  • Jing, P., J. A. Bomser, S. J. Schwartz, J. He, B. A. Magnuson, and M. M. Giusti. 2008. Structure-function relationships of anthocyanins from various anthocyanin-rich extracts on the inhibition of colon cancer cell growth . Journal of Agricultural and Food Chemistry 56 (20):9391–8. doi: 10.1021/jf8005917.
  • Jing, P., B. J. Qian, S. J. Zhao, X. Qi, L. Ye, M. M. Giusti, and X. Y. Wang. 2015. Effect of glycosylation patterns of Chinese eggplant anthocyanins and other derivatives on antioxidant effectiveness in human colon cell lines. Food Chemistry 172:183–9. doi: 10.1016/j.foodchem.2014.08.100.
  • Kalemba-Drożdż, M., A. Cierniak, and I. Cichoń. 2020. Berry fruit juices protect lymphocytes against DNA damage and ROS formation induced with heterocyclic aromatic amine PhIP. Journal of Berry Research 10 (1):95–113. doi: 10.3233/JBR-190429.
  • Kausar, H., J. Jeyabalan, F. Aqil, D. Chabba, J. Sidana, I. P. Singh, and R. C. Gupta. 2012. Berry anthocyanidins synergistically suppress growth and invasive potential of human non-small-cell lung cancer cells. Cancer Letters 325 (1):54–62. doi: 10.1016/j.canlet.2012.05.029.
  • Kazan, A., C. Sevimli-Gur, O. Yesil-Celiktas, and N. T. Dunford. 2016. Investigating anthocyanin contents and in vitro tumor suppression properties of blueberry extracts prepared by various processes. European Food Research and Technology 242 (5):693–701. doi: 10.1007/s00217-015-2577-9.
  • Lage, N. N., M. A. A. Layosa, S. Arbizu, B. P. Chew, M. L. Pedrosa, S. Mertens-Talcott, S. Talcott, and G. D. Noratto. 2020. Dark sweet cherry (Prunus avium) phenolics enriched in anthocyanins exhibit enhanced activity against the most aggressive breast cancer subtypes without toxicity to normal breast cells. Journal of Functional Foods 64:103710. doi: 10.1016/j.jff.2019.103710.
  • Lee, D. Y., S. M. Yun, M. Y. Song, K. Jung, and E. H. Kim. 2020. Cyanidin chloride induces apoptosis by inhibiting NF-κB signaling through activation of Nrf2 in colorectal cancer cells. Antioxidants 9 (4):285. doi: 10.3390/antiox9040285.
  • Li, W. L., H. Y. Yu, X. J. Zhang, M. Ke, and T. Hong. 2018. Purple sweet potato anthocyanin exerts antitumor effect in bladder cancer. Oncology Reports 40 (1):73–82. doi: 10.3892/or.2018.6421.
  • Lila, M. A., B. Burton-Freeman, M. Grace, and W. Kalt. 2016. Unraveling anthocyanin bioavailability for human health. Annual Review of Food Science and Technology 7:375–93. doi: 10.1146/annurev-food-041715-033346.
  • Lim, S., J. Xu, J. Kim, T.-Y. Chen, X. Su, J. Standard, E. Carey, J. Griffin, B. Herndon, B. Katz, et al. 2013. Role of anthocyanin-enriched purple-fleshed sweet potato p40 in colorectal cancer prevention. Molecular Nutrition & Food Research 57 (11):1908–17. doi: 10.1002/mnfr.201300040.
  • Lin, B. W., C. C. Gong, H. F. Song, and Y. Y. Cui. 2017. Effects of anthocyanins on the prevention and treatment of cancer. British Journal of Pharmacology 174 (11):1226–43. doi: 10.1111/bph.13627.
  • Liu, X., L. Wang, N. Jing, G. Jiang, and Z. Liu. 2020. Biostimulating gut microbiome with bilberry anthocyanin combo to enhance anti-PD-L1 efficiency against murine colon cancer. Microorganisms 8 (2):175. doi: 10.3390/microorganisms8020175.
  • Longo, L., F. Platini, A. Scardino, O. Alabiso, G. Vasapollo, and L. Tessitore. 2008. Autophagy inhibition enhances anthocyanin-induced apoptosis in hepatocellular carcinoma. Molecular Cancer Therapeutics 7 (8):2476–85. doi: 10.1158/1535-7163.MCT-08-0361.
  • López de Las Hazas, M.-C., J. I. Mosele, A. Macià, I. A. Ludwig, and M.-J. Motilva. 2017. Exploring the colonic metabolism of grape and strawberry anthocyanins and their in vitro apoptotic effects in HT-29 colon cancer cells. Journal of Agricultural and Food Chemistry 65 (31):6477–87. doi: 10.1021/acs.jafc.6b04096.
  • Lu, J. N., W. S. Lee, A. Nagappan, S. H. Chang, Y. H. Choi, H. J. Kim, G. S. Kim, C. H. Ryu, S. C. Shin, J. M. Jung, et al. 2015. Anthocyanins from the fruit of vitis coignetiae pulliat potentiate the cisplatin activity by inhibiting PI3K/Akt signaling pathways in human gastric cancer cells. Journal of Cancer Prevention 20 (1):50–6. doi: 10.15430/JCP.2015.20.1.50.
  • Lu, J. N., R. Panchanathan, W. S. Lee, H. J. Kim, D. H. Kim, Y. H. Choi, G. S. Kim, S. C. Shin, and S. C. Hong. 2017. Anthocyanins from the fruit of vitis coignetiae pulliat inhibit tnf-augmented cancer proliferation, migration, and invasion in a549 cells. Asian Pacific Journal of Cancer Prevention: APJCP 18 (11):2919–23. doi: 10.22034/APJCP.2017.18.11.2919.
  • Mazewski, C., M. S. Kim, and E. G. D. Mejia. 2019. Anthocyanins, delphinidin-3-O-glucoside and cyanidin-3-O-glucoside, inhibit immune checkpoints in human colorectal cancer cells in vitro and in silico. Scientific Reports 9 (1):1–15. doi: 10.1038/s41598-019-47903-0.
  • Mazewski, C., K. Liang, and E. G. D. Mejia. 2017. Inhibitory potential of anthocyanin-rich purple and red corn extracts on human colorectal cancer cell proliferation in vitro. Journal of Functional Foods 34:254–65. doi: 10.1016/j.jff.2017.04.038.
  • Mazzoni, L., F. Giampieri, J. M. A. Suarez, M. Gasparrini, B. Mezzetti, T. Y. F. Hernandez, and M. A. Battino. 2019. Isolation of strawberry anthocyanin-rich fractions and their mechanisms of action against murine breast cancer cell lines. Food & Function 10 (11):7103–20. doi: 10.1039/c9fo01721f.
  • Pan, F., Y. Liu, J. Liu, and E. Wang. 2019. Stability of blueberry anthocyanin, anthocyanidin and pyranoanthocyanidin pigments and their inhibitory effects and mechanisms in human cervical cancer HeLa cells. RSC Advances 9 (19):10842–53. doi: 10.1039/C9RA01772K.
  • Peiffer, D. S., L.-S. Wang, N. P. Zimmerman, B. W. S. Ransom, S. G. Carmella, C.-T. Kuo, J.-H. Chen, K. Oshima, Y.-W. Huang, S. S. Hecht, et al. 2016. Dietary consumption of black raspberries or their anthocyanin constituents alters innate immune cell trafficking in esophageal cancer. Cancer Immunology Research 4 (1):72–82. doi: 10.1158/2326-6066.CIR-15-0091.
  • Qamar, M., S. Akhtar, T. Ismail, P. Sestili, A. Tawab, and N. Ahmed. 2020. Anticancer and anti-inflammatory perspectives of Pakistan’s indigenous berry Grewia asiatica Linn (Phalsa). Journal of Berry Research 10 (1):115–31. doi: 10.3233/JBR-190459.
  • Shin, D. Y., C. H. Ryu, W. S. Lee, D. C. Kim, S. H. Kim, Y. S. Hah, S. J. Lee, S. C. Shin, H. S. Kang, and Y. H. Choi. 2009. Induction of apoptosis and inhibition of invasion in human hepatoma cells by anthocyanins from meoru. Annals of the New York Academy of Sciences 1171 (1):137–48. doi: 10.1111/j.1749-6632.2009.04689.x.
  • Singh, A. N., M. M. Baruah, and N. Sharma. 2017. Structure-based docking studies towards exploring potential anti-androgen activity of selected phytochemicals against prostate cancer. Scientific Reports 7 (1):1–8. doi: 10.1038/s41598-017-02023-5.
  • Sousa, A., P. Araújo, J. Azevedo, L. Cruz, I. Fernandes, N. Mateus, and V. de Freitas. 2016. Antioxidant and antiproliferative properties of 3-deoxyanthocyanidins . Food Chemistry 192:142–8. doi: 10.1016/j.foodchem.2015.06.108.
  • Tan, Y. F., M. Wang, Z. Y. Chen, L. Wang, and X. H. Liu. 2020. Inhibition of BRD4 prevents proliferation and epithelial–mesenchymal transition in renal cell carcinoma via NLRP3 inflammasome-induced pyroptosis. Cell Death & Disease 11 (4):239. doi: 10.1038/s41419-020-2431-2.
  • Thi, N. D., and E. S. Hwang. 2018. Effects of black chokeberry extracts on metastasis and cell-cycle arrest in sk-hep1 human liver cancer cell line. Asian Pacific Journal of Tropical Biomedicine 8 (6):285–91. doi: 10.4103/2221-1691.235313.
  • Venancio, V. P., P. A. Cipriano, H. Kim, L. M. Antunes, S. T. Talcott, and S. U. Mertens-Talcott. 2017. Cocoplum (Chrysobalanus icaco L.) anthocyanins exert anti-inflammatory activity in human colon cancer and non-malignant colon cells. Food & Function 8 (1):307–14. doi: 10.1039/c6fo01498d.
  • Vuolo, M. M., Â. G. Batista, A. C. T. Biasoto, L. C. Correa, M. R. M. Júnior, and R. H. Liu. 2019. Red-jambo peel extract shows antiproliferative activity against HepG2 human hepatoma cells. Food Research International (Ottawa, Ont.) 124:93–100. doi: 10.1016/j.foodres.2018.08.040.
  • Wang, L., G. Jiang, N. Jing, X. Liu, Q. Li, W. Liang, and Z. Liu. 2020. Bilberry anthocyanin extracts enhance anti-PD-L1 efficiency by modulating gut microbiota. Food & Function 11 (4):3180–90. doi:10.1039/D0FO00255K.
  • Wang, E., Y. Liu, C. Xu, and J. Liu. 2017. Antiproliferative and proapoptotic activities of anthocyanin and anthocyanidin extracts from blueberry fruits on B16-F10 melanoma cells. Food & Nutrition Research 61 (1):1325308. doi: 10.1080/16546628.2017.1325308.
  • Wang, L. S., and G. D. Stoner. 2008. Anthocyanins and their role in cancer prevention. Cancer Letters 269 (2):281–90. doi: 10.1016/j.canlet.2008.05.020.
  • Wang, X., D. Y. Yang, L. Q. Yang, W. Z. Zhao, L. Y. Cai, and H. P. Shi. 2019. Anthocyanin consumption and risk of colorectal cancer: A meta-analysis of observational studies. Journal of the American College of Nutrition 38 (5):470–7. doi: 10.1080/07315724.2018.1531084.
  • Yue, E., G. Tuguzbaeva, X. Chen, Y. Qin, A. Li, X. Sun, C. Dong, Y. Liu, Y. Yu, S. M. Zahra, et al. 2019. Anthocyanin is involved in the activation of pyroptosis in oral squamous cell carcinoma. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 56:286–94. doi: 10.1016/j.phymed.2018.09.223.
  • Zhang, Y. B., X. F. Pan, J. Chen, A. Cao, Y. G. Zhang, L. Xia, J. Wang, H. Q. Li, G. Liu, and A. Pan. 2020. Combined lifestyle factors, incident cancer, and cancer mortality: A systematic review and meta-analysis of prospective cohort studies. British Journal of Cancer 122 (7):1085–9. doi: 10.1038/s41416-020-0741-x.

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