Impact of hesperidin in 100% orange juice on chronic disease biomarkers: A narrative systematic review and gap analysis

References

• Adefegha, S. A., D. B. R. Leal, A. A. Olabiyi, G. Oboh, and L. G. Castilhos. 2017. Hesperidin attenuates inflammation and oxidative damage in pleural exudates and liver of rat model of pleurisy. Redox Report 22 (6):563–71. doi: 10.1080/13510002.2017.1344013.
   PubMed Web of Science ®Google Scholar
• Alharbi, M. H., D. J. Lamport, G. F. Dodd, C. Saunders, L. Harkness, L. T. Butler, and J. P. E. Spencer. 2016. Flavonoid-rich orange juice is associated with acute improvements in cognitive function in healthy middle-aged males. European Journal of Nutrition 55 (6):2021–9. doi: 10.1007/s00394-015-1016-9.
   PubMed Web of Science ®Google Scholar
• Arts, M. J. T. J., G. R. M. M. Haenen, H. P. Voss, and A. Bast. 2001. Masking of antioxidant capacity by the interaction of flavonoids with protein. Food and Chemical Toxicology 39 (8):787–91. https://doi.org/10.1016/S0278-6915(01)00020-5. doi: 10.1016/S0278-6915(01)00020-5.
   PubMed Web of Science ®Google Scholar
• Aschoff, J. K., S. Kaufmann, O. Kalkan, S. Neidhart, R. Carle, and R. M. Schweiggert. 2015. In vitro bioaccessibility of carotenoids, flavonoids, and vitamin C from differently processed oranges and orange juices [Citrus sinensis (L.) Osbeck]. Journal of Agricultural and Food Chemistry 63 (2):578–87. doi: 10.1021/jf505297t.
   PubMed Web of Science ®Google Scholar
• Benavente-García, O., and J. Castillo. 2008. Update on uses and properties of citrus flavonoids: New findings in anticancer, cardiovascular, and anti-inflammatory activity. Journal of Agricultural and Food Chemistry 56 (15):6185–205. doi: 10.1021/jf8006568.
   PubMed Web of Science ®Google Scholar
• Boeing, H., A. Bechthold, A. Bub, S. Ellinger, D. Haller, A. Kroke, E. Leschik-Bonnet, M. J. Müller, H. Oberritter, M. Schulze, et al. 2012. Critical review: Vegetables and fruit in the prevention of chronic diseases. European Journal of Nutrition 51 (6):637–63. doi: 10.1007/s00394-012-0380-y.
   PubMed Web of Science ®Google Scholar
• Buscemi, S., G. Rosafio, G. Arcoleo, A. Mattina, B. Canino, M. Montana, S. Verga, and G. Rini. 2012. Effects of red orange juice intake on endothelial function and inflammatory markers in adult subjects with increased cardiovascular risk. American Journal of Clinical Nutrition 95 (5):1089–95. doi: 10.3945/ajcn.111.031088.
   PubMed Web of Science ®Google Scholar
• Cassidy, A., and A. M. Minihane. 2017. The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids. The American Journal of Clinical Nutrition 105 (1):10–22. doi: 10.3945/ajcn.116.136051.
   PubMed Web of Science ®Google Scholar
• “Centre for Evaluation and Monitoring. D.U. Effect Size Calculator.” 2017. Durham: Centre for Evaluation and Monitoring.
   Google Scholar
• Chiba, H., M. Uehara, J. Wu, X. Wang, R. Masuyama, K. Suzuki, K. Kanazawa, and Y. Ishimi. 2003. Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice. The Journal of Nutrition 133 (6):1892–7. doi: 10.1093/jn/133.6.1892.
   PubMed Web of Science ®Google Scholar
• Constans, J., C. Bennetau-Pelissero, J. F. Martin, E. Rock, A. Mazur, A. Bedel, C. Morand, and A. M. Bérard. 2015. Marked antioxidant effect of orange juice intake and its phytomicronutrients in a preliminary randomized cross-over trial on mild hypercholesterolemic men. Clinical Nutrition 34 (6):1093–100. doi: 10.1016/j.clnu.2014.12.016.
   PubMed Web of Science ®Google Scholar
• Crowe-White, K., J. S. Parrott, K. S. Stote, M. Gutschall, S. Benson-Davies, E. Droke, C. E. O’Neil, T. Wolfram, and P. Ziegler. 2017. Metabolic impact of 100% fruit juice consumption on antioxidant/oxidant status and lipid profiles of adults: An evidence-based review. Critical Reviews in Food Science and Nutrition 57 (1):152–62. doi: 10.1080/10408398.2015.1102861.
   PubMed Web of Science ®Google Scholar
• Dourado, G. K. Z. S., and T. B. Cesar. 2015. Investigation of cytokines, oxidative stress, metabolic, and inflammatory biomarkers after orange juice consumption by normal and overweight subjects. Food & Nutrition Research 59 (1):28147. doi: 10.3402/fnr.v59.28147.
   PubMed Web of Science ®Google Scholar
• Erlund, I., E. Meririnne, G. Alfthan, and A. Aro. 2001. Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice. The Journal of Nutrition 131 (2):235–41. doi: 10.1093/jn/131.2.235.
   PubMed Web of Science ®Google Scholar
• Escudero-López, B., Á. Ortega, I. Cerrillo, M.-R. Rodríguez-Griñolo, R. Muñoz-Hernández, H. C. Macher, F. Martín, D. Hornero-Méndez, P. Mena, D. Del Rio, et al. 2018. Consumption of orange fermented beverage improves antioxidant status and reduces peroxidation lipid and inflammatory markers in healthy humans. Journal of the Science of Food and Agriculture 98 (7):2777–86. doi: 10.1002/jsfa.8774.
   PubMed Web of Science ®Google Scholar
• Estruel-Amades, S., M. Massot-Cladera, P. Garcia-Cerdà, F. J. Pérez-Cano, À. Franch, M. Castell, and M. Camps-Bossacoma. 2019. Protective effect of hesperidin on the oxidative stress induced by an exhausting exercise in intensively trained rats. Nutrients 11 (4):783. doi: 10.3390/nu11040783.
   PubMed Web of Science ®Google Scholar
• “Flavonoids.” 2021. Linus Pauling Institute. https://lpi.oregonstate.edu/mic/dietary-factors/phytochemicals/flavonoids
   Google Scholar
• Foroudi, S., A. S. Potter, A. Stamatikos, B. S. Patil, and F. Deyhim. 2014. Drinking orange juice increases total antioxidant status and decreases lipid peroxidation in adults. Journal of Medicinal Food 17 (5):612–7. doi: 10.1089/jmf.2013.0034.
   PubMed Web of Science ®Google Scholar
• Franke, A. A., R. V. Cooney, S. M. Henning, and L. J. Custer. 2005. Bioavailability and antioxidant effects of orange juice components in humans. Journal of Agricultural and Food Chemistry 53 (13):5170–8. doi: 10.1021/jf050054y.
   PubMed Web of Science ®Google Scholar
• Ghanim, H., P. Mohanty, R. Pathak, A. Chaudhuri, C. L. Sia, and P. Dandona. 2007. Orange juice or fructose intake does not induce oxidative and inflammatory response. Diabetes Care 30 (6):1406–11. doi: 10.2337/dc06-1458.
   PubMed Web of Science ®Google Scholar
• Gonçalves, D., C. Lima, P. Ferreira, P. Costa, A. Costa, W. Figueiredo, and T. Cesar. 2017. Orange juice as dietary source of antioxidants for patients with hepatitis C under antiviral therapy. Food & Nutrition Research 61 (1):1296675. doi: 10.1080/16546628.2017.1296675.
   PubMed Web of Science ®Google Scholar
• Grundy, S. M., J. I. Cleeman, S. R. Daniels, K. A. Donato, R. H. Eckel, B. A. Franklin, and D. J. Gordon. 2005. Diagnosis and management of the metabolic syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 112 (17):2735–52. doi: 10.1161/CIRCULATIONAHA.105.169404.
   PubMed Web of Science ®Google Scholar
• Higgins, J. P. T., D. G. Altman, and J. A. C. Sterne. 2017. Chapter 8: Assessing risk of bias in included studies. In Cochrane handbook for systematic reviews of interventions (version 5). Cochrane. https://training.cochrane.org/sites/training.cochrane.org/files/public/uploads/resources/Handbook5_1/Chapter_8_Handbook_5_2_8.pdf.
   Google Scholar
• Higgins, J. P. T., J. Thomas, J. Chandler, M. Cumpston, T. Li, M. J. Page, and V. A. Welch. 2019. Cochrane handbook for systematic reviews of interventions. 2nd ed. Chichester, UK: John Wiley & Sons.
   Google Scholar
• Hollands, W. J., C. N. Armah, J. F. Doleman, N. Perez-Moral, M. S. Winterbone, and P. A. Kroon. 2018. 4-Week consumption of anthocyanin-rich blood orange juice does not affect LDL-cholesterol or other biomarkers of CVD risk and glycaemia compared with standard orange juice: A randomised controlled trial. British Journal of Nutrition 119 (4):415–21. doi: 10.1017/S0007114517003865.
   PubMed Web of Science ®Google Scholar
• Ialongo, C. 2016. Understanding the effect size and its measures. Biochemia Medica 26 (2):150–63. doi: 10.11613/BM.2016.015.
   PubMed Web of Science ®Google Scholar
• Kean, R. J., D. J. Lamport, G. F. Dodd, J. E. Freeman, C. M. Williams, J. A. Ellis, L. T. Butler, and J. P. E. Spencer. 2015. Chronic consumption of flavanone-rich orange juice is associated with cognitive benefits: An 8-wk, randomized, double-blind, placebo-controlled trial in healthy older adults. American Journal of Clinical Nutrition 101 (3):506–14. doi: 10.3945/ajcn.114.088518.
   PubMed Web of Science ®Google Scholar
• Kurowska, E. M., J. D. Spence, J. Jordan, S. Wetmore, D. J. Freeman, L. A. Piche, and P. Serratore. 2000. HDL-Cholesterol-raising effect of orange juice in subjects with hypercholesterolemia. The American Journal of Clinical Nutrition 72 (5):1095–100. doi: 10.1093/ajcn/72.5.1095.
   PubMed Web of Science ®Google Scholar
• Li, L., G. K. Lyall, J. A. Martinez-Blazquez, F. Vallejo, F. A. Tomas-Barberan, K. M. Birch, and C. Boesch. 2020. Blood orange juice consumption increases flow-mediated dilation in adults with overweight and obesity: A randomized controlled trial. The Journal of Nutrition 150 (9):2287–94. doi: 10.1093/jn/nxaa158.
   PubMed Web of Science ®Google Scholar
• Manach, C., C. Morand, A. Gil-Izquierdo, C. Bouteloup-Demange, and C. Rémésy. 2003. Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two dose of orange juice. European Journal of Clinical Nutrition 57 (2):235–42. doi: 10.1038/sj.ejcn.1601547.
   PubMed Web of Science ®Google Scholar
• Martínez-Noguera, F. J., C. Marín-Pagán, J. Carlos-Vivas, J. A. Rubio-Arias, and P. E. Alcaraz. 2019. Acute effects of hesperidin in oxidant/antioxidant state markers and performance in amateur cyclists. Nutrients 11 (8):1898. doi: 10.3390/nu11081898.
   PubMed Web of Science ®Google Scholar
• Mohammadi, M., N. Ramezani-Jolfaie, E. Lorzadeh, Y. Khoshbakht, and A. Salehi-Abargouei. 2019. Hesperidin, a major flavonoid in orange juice, might not affect lipid profile and blood pressure: A systematic review and meta-analysis of randomized controlled clinical trials. Phytotherapy Research 33 (3):534–45. doi: 10.1002/ptr.6264.
   PubMed Web of Science ®Google Scholar
• Moher, D., A. Liberati, J. Tetzlaff, and D. Altman. 2009. PRISMA 2009 flow diagram. The PRISMA Statement. 6(7): e1000097.doi: 10.1371/journal.pmed1000097.
   Google Scholar
• Morand, C., C. Dubray, D. Milenkovic, D. Lioger, J. F. Martin, A. Scalbert, and A. Mazur. 2011. Hesperidin contributes to the vascular protective effects of orange juice: A randomized crossover study in healthy volunteers. American Journal of Clinical Nutrition 93 (1):73–80. doi: 10.3945/ajcn.110.004945.
   PubMed Web of Science ®Google Scholar
• Mullen, W., M. A. Archeveque, C. A. Edwards, H. Matsumoto, and A. Crozier. 2008. Bioavailability and metabolism of orange juice flavanones in humans: Impact of a full-fat yogurt. Journal of Agricultural and Food Chemistry 56 (23):11157–64. doi: 10.1021/jf801974v.
   PubMed Web of Science ®Google Scholar
• NCD mortality and morbidity. n.d. World Health Organization. Accessed January 18, 2020. https://www.who.int/gho/ncd/mortality_morbidity/en/.
   Google Scholar
• Neveu, V., J. Perez-Jiménez, F. Vos, V. Crespy, L. Du Chaffaut, L. Mennen, C. Knox, R. Eisner, J. Cruz, D. Wishart, et al. 2010. Phenol-explorer: An online comprehensive database on polyphenol contents in foods. Database 2010:bap024–bap024. doi: 10.1093/database/bap024.
   PubMedGoogle Scholar
• Nielsen, I. L. F., W. S. S. Chee, L. Poulsen, E. Offord-Cavin, S. E. Rasmussen, H. Frederiksen, M. Enslen, D. Barron, M.-N. Horcajada, and G. Williamson. 2006. Bioavailability is improved by enzymatic modification of the citrus flavonoid hesperidin in humans: A randomized, double-blind, crossover trial. The Journal of Nutrition 136 (2):404–8. doi: 10.1093/jn/136.2.404.
   PubMed Web of Science ®Google Scholar
• Nutrients and health benefits. n.d. U.S. Department of Agriculture. https://www.choosemyplate.gov/eathealthy/fruits/fruits-nutrients-health.
   Google Scholar
• Orange juice—Australia. 2020. Statista Market Forecast. https://www.statista.com/outlook/20030100/107/orange-juice/australia.
   Google Scholar
• Orange juice—United Kingdom. 2020. Statista Market Forecast. https://www.statista.com/outlook/20030100/156/orange-juice/united-kingdom.
   Google Scholar
• Orange juice—United States. 2020. Statista Market Forecast. https://www.statista.com/outlook/20030100/109/orange-juice/united-states#market-revenue.
   Google Scholar
• Orange juice—Worldwide. 2020. Statista Market Forecast. https://www.statista.com/outlook/20030100/100/orange-juice/worldwide.
   Google Scholar
• Panche, A. N., A. D. Diwan, and S. R. Chandra. 2016. Flavonoids: An overview. Journal of Nutritional Science 5:e47. doi: 10.1017/jns.2016.41.
   PubMed Web of Science ®Google Scholar
• Pascual-Teresa, S. D., C. Sánchez-Moreno, F. Granado, B. Olmedilla, B. D. Ancos, and M. P. Cano. 2007. Short and mid-term bioavailability of flavanones from oranges in humans. Current Topics in Nutraceutical Research 5 (2-3):129–34.
   Web of Science ®Google Scholar
• Perche, O., J. Vergnaud-Gauduchon, C. Morand, C. Dubray, A. Mazur, and M. P. Vasson. 2014. Orange juice and its major polyphenol hesperidin consumption do not induce immunomodulation in healthy well-nourished humans. Clinical Nutrition 33 (1):130–5. doi: 10.1016/j.clnu.2013.03.012.
   PubMed Web of Science ®Google Scholar
• Rangel-Huerta, O. D., C. M. Aguilera, M. V. Martin, M. J. Soto, M. C. Rico, F. Vallejo, F. Tomas-Barberan, A. J. Perez-de-la-Cruz, A. Gil, and M. D. Mesa. 2015. Normal or high polyphenol concentration in orange juice affects antioxidant activity, blood pressure, and body weight in obese or overweight adults. The Journal of Nutrition 145 (8):1808–16. doi: 10.3945/jn.115.213660.
   PubMed Web of Science ®Google Scholar
• Ritchie, H., and M. Roser. 2017. Diet compositions. Our world in data. https://ourworldindata.org/diet-compositions.
   Google Scholar
• Rizza, S., R. Muniyappa, M. Iantorno, J. A. Kim, H. Chen, P. Pullikotil, N. Senese, M. Tesauro, D. Lauro, C. Cardillo, et al. 2011. Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome. Journal of Clinical Endocrinology and Metabolism 96 (5):E782–92. doi: 10.1210/jc.2010-2879.
   PubMed Web of Science ®Google Scholar
• Schar, M. Y., P. J. Curtis, S. Hazim, L. M. Ostertag, C. D. Kay, J. F. Potter, and A. Cassidy. 2015. Orange juice-derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: A randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease. American Journal of Clinical Nutrition 101 (5):931–8. doi: 10.3945/ajcn.114.104364.
   PubMed Web of Science ®Google Scholar
• Selvaraj, P., and K. V. Pugalendi. 2010. Hesperidin, a flavanone glycoside, on lipid peroxidation and antioxidant status in experimental myocardial ischemic rats. Redox Report 15 (5):217–23. doi: 10.1179/135100010X12826446921509.
   PubMed Web of Science ®Google Scholar
• Sharmin, S., K. Kypri, M. Khanam, M. Wadolowski, R. Bruno, and R. P. Mattick. 2017. Parental supply of alcohol in childhood and risky drinking in adolescence: Systematic review and meta-analysis. International Journal of Environmental Research and Public Health 14 (3):287. doi: 10.3390/ijerph14030287.
   PubMed Web of Science ®Google Scholar
• Simpson, E. J., B. Mendis, and I. A. Macdonald. 2016. Orange juice consumption and its effect on blood lipid profile and indices of the metabolic syndrome: A randomised, controlled trial in an at-risk population. Food and Function 7 (4):1884–91. doi: 10.1039/c6fo00039h.
   PubMed Web of Science ®Google Scholar
• Smith, C., B. Halliwell, and O. I. Aruoma. 1992. Protection by albumin against the pro-oxidant actions of phenolic dietary components. Food and Chemical Toxicology 30 (6):483–9. https://doi.org/10.1016/0278-6915(92)90099-7. doi: 10.1016/0278-6915(92)90099-7.
   PubMed Web of Science ®Google Scholar
• Snyder, S. M., J. D. Reber, B. L. Freeman, K. Orgad, D. L. Eggett, and T. L. Parker. 2011. Controlling for sugar and ascorbic acid, a mixture of flavonoids matching navel oranges significantly increases human postprandial serum antioxidant capacity. Nutrition Research 31 (7):519–26. doi: 10.1016/j.nutres.2011.06.006.
   PubMed Web of Science ®Google Scholar
• State Indicator Report on Fruits and Vegetables. 2018. Atlanta, GA. https://www.cdc.gov/nutrition/downloads/fruits-vegetables/2018/2018-fruit-vegetable-report-508.pdf.
   Google Scholar
• Stevens, Y., E. V. Rymenant, C. Grootaert, J. V. Camp, S. Possemiers, A. Masclee, and D. Jonkers. 2019. The intestinal fate of citrus flavanones and their effects on gastrointestinal health. Nutrients 11 (7):1464. doi: 10.3390/nu11071464.
   PubMed Web of Science ®Google Scholar
• Sullivan, G. M., and R. Feinn. 2012. Using effect size—or why the P value is not enough. Journal of Graduate Medical Education 4 (3):279–82. doi: 10.4300/JGME-D-12-00156.1.
   PubMedGoogle Scholar
• The power of prevention; chronic disease … the public health challenge of the 21st century. 2009. Atlanta, GA: National Center for Chronic Disease Prevention and Health Promotion. https://www.cdc.gov/chronicdisease/pdf/2009-Power-of-Prevention.pdf.
   Google Scholar
• Valls, R. M., A. Pedret, L. Calderón-Pérez, E. Llauradó, L. Pla-Pagà, J. Companys, A. Moragas, F. Martín-Luján, Y. Ortega, M. Giralt, et al. 2021. Effects of hesperidin in orange juice on blood and pulse pressures in mildly hypertensive individuals: A randomized controlled trial (citrus study). European Journal of Nutrition 60 (3):1277–88. doi: 10.1007/s00394-020-02279-0.
   PubMed Web of Science ®Google Scholar
• Raghupathi, W., and V. Raghupathi. 2018. An empirical study of chronic diseases in the United States: A visual analytics approach. International Journal of Environmental Research and Public Health 15 (3):431. doi: 10.3390/ijerph15030431.
   PubMed Web of Science ®Google Scholar
• Wells, G. A., B. Shea, D. O’Connell, J. Peterson, V. Welch, M. Losos, and P. Tugwell. 2019. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa Hospital Research Institute. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.
   Google Scholar
• WHO. 2011. World Health Organization: Global status report on noncommunicable diseases 2010. WHO Library Cataloguing-in-Publication Data. .
   Google Scholar
• Williams, M. R. I., R. A. Westerman, B. A. Kingwell, J. Paige, P. A. Blombery, K. Sudhir, and P. A. Komesaroff. 2001. Variations in endothelial function and arterial compliance during the menstrual cycle. The Journal of Clinical Endocrinology & Metabolism 86 (11):5389–95. doi: 10.1210/jcem.86.11.8013.
   PubMed Web of Science ®Google Scholar
• Xiao, J., F. Mao, F. Yang, Y. Zhao, C. Zhang, and K. Yamamoto. 2011. Interaction of dietary polyphenols with bovine milk proteins: Molecular structure-affinity relationship and influencing bioactivity aspects. Molecular Nutrition and Food Research 55 (11):1637–45. doi: 10.1002/mnfr.201100280.
   PubMed Web of Science ®Google Scholar
• Xiong, H., J. Wang, Q. Ran, G. Lou, C. Peng, Q. Gan, J. Hu, J. Sun, R. Yao, and Q. Huang. 2019. Hesperidin: A therapeutic agent for obesity. Drug Design, Development and Therapy 13:3855–66. doi: 10.2147/DDDT.S227499.
   PubMed Web of Science ®Google Scholar