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Unraveling enterohemorrhagic Escherichia coli infection: the promising role of dietary compounds and probiotics in bacterial elimination and host innate immunity boosting

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  • Abdullah, A., Asghar, A. Algburi, et al. 2021. Anti-biofilm potential of Elletaria cardamomum essential oil against Escherichia coli O157:H7 and Salmonella Typhimurium JSG 1748. Frontiers in Microbiology 12:620227.
  • Abutheraa, R., N. Hettiarachchy, G. Kumar-Phillips, R. Horax, P. Chen, R. Morawicki, and Y. M. Kwon. 2017. Antimicrobial activities of phenolic extracts derived from seed coats of selected soybean varieties. Journal of Food Science 82 (3):731–7. doi: 10.1111/1750-3841.13644.
  • Aditya, A., Z. Alvarado-Martinez, V. Nagarajan, M. Peng, and D. Biswas. 2019. Antagonistic effects of phenolic extracts of Chokeberry pomace on E. coli O157: H7 but not on probiotic and normal bacterial flora. Journal of Berry Research 9 (3):459–72. doi: 10.3233/JBR-190383.
  • Ahmed, B., M. Loos, D. Vanrompay, and E. Cox. 2014. Oral immunization with Lactococcus lactis-expressing EspB induces protective immune responses against Escherichia coli O157:H7 in a murine model of colonization. Vaccine 32 (31):3909–16. doi: 10.1016/j.vaccine.2014.05.054.
  • Akbari, P., S. Braber, A. Alizadeh, K. A. Verheijden, M. H. Schoterman, A. D. Kraneveld, J. Garssen, and J. Fink-Gremmels. 2015. Galacto-oligosaccharides protect the intestinal barrier by maintaining the tight junction network and modulating the inflammatory responses after a challenge with the mycotoxin deoxynivalenol in human Caco-2 cell monolayers and B6C3F1 mice. The Journal of Nutrition 145 (7):1604–13. doi: 10.3945/jn.114.209486.
  • Allen-Vercoe, E., B. Waddell, M. C. W. Toh, and R. DeVinney. 2006. Amino acid residues within enterohemorrhagic Escherichia coli O157:H7 Tir involved in phosphorylation, alpha-actinin recruitment, and Nck-independent pedestal formation. Infection and Immunity 74 (11):6196–205. doi: 10.1128/IAI.00753-06.
  • Ananda Baskaran, S., and K. Venkitanarayanan. 2014. 2014. Plant-derived antimicrobials reduce E. coli O157:H7 virulence factors critical for colonization in cattle gastrointestinal tract in vitro. Biomed Research International 2014:1–10. doi: 10.1155/2014/212395.
  • Arbeloa, A., R. R. Bulgin, G. MacKenzie, R. K. Shaw, M. J. Pallen, V. F. Crepin, C. N. Berger, and G. Frankel. 2008. Subversion of actin dynamics by EspM effectors of attaching and effacing bacterial pathogens. Cellular Microbiology 10 (7):1429–41. doi: 10.1111/j.1462-5822.2008.01136.x.
  • Ayabe, T., D. P. Satchell, C. L. Wilson, W. C. Parks, M. E. Selsted, and A. J. Ouellette. 2000. Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nature Immunology 1 (2):113–8. doi: 10.1038/77783.
  • Basset, C., J. Holton, R. O’Mahony, and I. Roitt. 2003. Innate immunity and pathogen-host interaction. Vaccine 21 (Suppl 2):S12–S23. doi: 10.1016/S0264-410X(03)00195-6.
  • Batchelor, M., S. Prasannan, S. Daniell, S. Reece, I. Connerton, G. Bloomberg, G. Dougan, G. Frankel, and S. Matthews. 2000. Structural basis for recognition of the translocated intimin receptor (Tir) by intimin from enteropathogenic Escherichia coli. The EMBO Journal 19 (11):2452–64. doi: 10.1093/emboj/19.11.2452.
  • Bielaszewska, M., C. Rüter, L. Kunsmann, L. Greune, A. Bauwens, W. Zhang, T. Kuczius, K. S. Kim, A. Mellmann, M. A. Schmidt, et al. 2013. Enterohemorrhagic Escherichia coli hemolysin employs outer membrane vesicles to target mitochondria and cause endothelial and epithelial apoptosis. PLoS Pathogens 9 (12):e1003797. doi: 10.1371/journal.ppat.1003797.
  • Blasche, S., M. Mörtl, H. Steuber, G. Siszler, S. Nisa, F. Schwarz, I. Lavrik, T. M. A. Gronewold, K. Maskos, M. S. Donnenberg, et al. 2013. The E. coli effector protein NleF is a caspase inhibitor. PLoS One 8 (3):e58937. doi: 10.1371/journal.pone.0058937.
  • Bonvicini, F., E. Pagnotta, A. Punzo, et al. 2020. Effect of Lactobacillus acidophilus fermented broths enriched with Eruca sativa seed extracts on intestinal barrier and inflammation in a co-culture system of an enterohemorrhagic Escherichia coli and human intestinal cells. Nutrients 12 (10): 3064. doi: 10.3390/nu12103064. PMC: 33036498
  • Callaway, T. R., J. A. Carroll, J. D. Arthington, C. Pratt, T. S. Edrington, R. C. Anderson, M. L. Galyean, S. C. Ricke, P. Crandall, D. J. Nisbet, et al. 2008. Citrus products decrease growth of E. coli O157:H7 and Salmonella typhimurium in pure culture and in fermentation with mixed ruminal microorganisms in vitro. Foodborne Pathogens and Disease 5 (5):621–7. doi: 10.1089/fpd.2008.0088.
  • Campellone, K. G., D. Robbins, and J. M. Leong. 2004. EspFU is a translocated EHEC effector that interacts with Tir and N-WASP and promotes Nck-independent actin assembly. Developmental Cell 7 (2):217–28. doi: 10.1016/j.devcel.2004.07.004.
  • Cario, E., G. Gerken, and D. K. Podolsky. 2004. Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C. Gastroenterology 127 (1):224–38. doi: 10.1053/j.gastro.2004.04.015.
  • Chen, X., J. Xu, J. Shuai, J. Chen, Z. Zhang, and W. Fang. 2007. The S-layer proteins of Lactobacillus crispatus strain ZJ001 is responsible for competitive exclusion against Escherichia coli O157:H7 and Salmonella Typhimurium. International Journal of Food Microbiology 115 (3):307–12. doi: 10.1016/j.ijfoodmicro.2006.11.007.
  • Chuenkitiyanon, S., T. Pengsuparp, and S. Jianmongkol. 2010. Protective effect of quercetin on hydrogen peroxide-induced tight junction disruption. International Journal of Toxicology 29 (4):418–24. doi: 10.1177/1091581810366487.
  • Chung, J., S. Kim, H. A. Lee, M. H. Park, S. Kim, Y. R. Song, and H. S. Na. 2018. Trans-cinnamic aldehyde inhibits Aggregatibacter actinomycetemcomitans-induced inflammation in THP-1-derived macrophages via autophagy activation. Journal of Periodontology 89 (10):1262–71. doi: 10.1002/JPER.17-0727.
  • Crepin, V. F., F. Girard, S. Schüller, A. D. Phillips, A. Mousnier, and G. Frankel. 2010. Dissecting the role of the Tir: Nck and Tir:IRTKS/IRSp53 signalling pathways in vivo. Molecular Microbiology 75 (2):308–23. doi: 10.1111/j.1365-2958.2009.06938.x.
  • Dahan, S., G. Dalmasso, V. Imbert, J.-F. Peyron, P. Rampal, and D. Czerucka. 2003. Saccharomyces boulardii interferes with enterohemorrhagic Escherichia coli-induced signaling pathways in T84 cells. Infection and Immunity 71 (2):766–73. doi: 10.1128/IAI.71.2.766-773.2003.
  • De, R., P. Kundu, S. Swarnakar, T. Ramamurthy, A. Chowdhury, G. B. Nair, and A. K. Mukhopadhyay. 2009. Antimicrobial activity of curcumin against Helicobacter pylori isolates from India and during infections in mice. Antimicrobial Agents and Chemotherapy 53 (4):1592–7. doi: 10.1128/AAC.01242-08.
  • Dean, P., and B. Kenny. 2004. Intestinal barrier dysfunction by enteropathogenic Escherichia coli is mediated by two effector molecules and a bacterial surface protein. Molecular Microbiology 54 (3):665–75. doi: 10.1111/j.1365-2958.2004.04308.x.
  • Dettmar, A. K., E. Binder, F. R. Greiner, M. C. Liebau, C. E. Kurschat, T. C. Jungraithmayr, M. A. Saleem, C.-P. Schmitt, E. Feifel, D. Orth-Höller, et al. 2014. Protection of human podocytes from shiga toxin 2-induced phosphorylation of mitogen-activated protein kinases and apoptosis by human serum amyloid P component. Infection and Immunity 82 (5):1872–9. doi: 10.1128/IAI.01591-14.
  • Eckelman, B. P., G. S. Salvesen, and F. L. Scott. 2006. Human inhibitor of apoptosis proteins: Why XIAP is the black sheep of the family. EMBO Reports 7 (10):988–94. doi: 10.1038/sj.embor.7400795.
  • Elphick, D. A., and Y. R. Mahida. 2005. Paneth cells: Their role in innate immunity and inflammatory disease. Gut 54 (12):1802–9. doi: 10.1136/gut.2005.068601.
  • Fang, K., X. Jin, and S. H. Hong. 2018. Probiotic Escherichia coli inhibits biofilm formation of pathogenic E. coli via extracellular activity of DegP. Scientific Reports 8 (1):4939. doi: 10.1038/s41598-018-23180-1.
  • Ganz, T. 2003. Defensins: Antimicrobial peptides of innate immunity. Nature Reviews Immunology 3 (9):710–20. doi: 10.1038/nri1180.
  • Gao, X., X. Wang, T. H. Pham, L. A. Feuerbacher, M.-L. Lubos, M. Huang, R. Olsen, A. Mushegian, C. Slawson, P. R. Hardwidge, et al. 2013. NleB, a bacterial effector with glycosyltransferase activity, targets GAPDH function to inhibit NF-κB activation. Cell Host & Microbe 13 (1):87–99. doi: 10.1016/j.chom.2012.11.010.
  • Gao, X., F. Wan, K. Mateo, E. Callegari, D. Wang, W. Deng, J. Puente, F. Li, M. S. Chaussee, B. B. Finlay, et al. 2009. Bacterial effector binding to ribosomal protein s3 subverts NF-kappaB function. PLoS Pathogens 5 (12):e1000708. doi: 10.1371/journal.ppat.1000708.
  • Garmendia, J., A. D. Phillips, M.-F. Carlier, Y. Chong, S. Schüller, O. Marches, S. Dahan, E. Oswald, R. K. Shaw, S. Knutton, et al. 2004. TccP is an enterohaemorrhagic Escherichia coli O157:H7 type III effector protein that couples Tir to the actin-cytoskeleton. Cellular Microbiology 6 (12):1167–83. doi: 10.1111/j.1462-5822.2004.00459.x.
  • Gerhard, R., G. Schmidt, F. Hofmann, and K. Aktories. 1998. Activation of Rho GTPases by Escherichia coli cytotoxic necrotizing factor 1 increases intestinal permeability in Caco-2 cells. Infection and Immunity 66 (11):5125–31. doi: 10.1128/IAI.66.11.5125-5131.1998.
  • Gill, A. O., and R. A. Holley. 2006. Disruption of Escherichia coli, Listeria monocytogenes and Lactobacillus sakei cellular membranes by plant oil aromatics. International Journal of Food Microbiology 108 (1):1–9. doi: 10.1016/j.ijfoodmicro.2005.10.009.
  • Goosney, D. L., R. DeVinney, and B. B. Finlay. 2001. Recruitment of cytoskeletal and signaling proteins to enteropathogenic and enterohemorrhagic Escherichia coli pedestals. Infection and Immunity 69 (5):3315–22. doi: 10.1128/IAI.69.5.3315-3322.2001.
  • Griffin, P. M., and R. V. Tauxe. 1991. The epidemiology of infections caused by Escherichia coli O157:H7, other enterohemorrhagic E. coli, and the associated hemolytic uremic syndrome. Epidemiologic Reviews 13:60–98. doi: 10.1093/oxfordjournals.epirev.a036079.
  • Hall, A., A. Troupin, B. Londono-Renteria, and T. M. Colpitts. 2017. Garlic organosulfur compounds reduce inflammation and oxidative stress during dengue virus infection. Viruses 9 (7):159. doi: 10.3390/v9070159.
  • Hart, A. L., A. J. Stagg, and M. A. Kamm. 2003. Use of probiotics in the treatment of inflammatory bowel disease. Journal of Clinical Gastroenterology 36 (2):111–9. doi: 10.1097/00004836-200302000-00005.
  • Hayward, J. A., A. Mathur, C. Ngo, et al. 2018. Cytosolic recognition of microbes and pathogens: Inflammasomes in action. Microbiology and Molecular Biology Reviews 82 (4):e0001500018. doi: 10.1128/MMBR.00015-18.
  • Hotchkiss, A. T., A. Nuñez, G. D. Strahan, H. K. Chau, A. K. White, J. P. J. Marais, K. Hom, M. S. Vakkalanka, R. Di, K. L. Yam, et al. 2015. Cranberry xyloglucan structure and inhibition of Escherichia coli adhesion to epithelial cells. Journal of Agricultural and Food Chemistry 63 (23):5622–33. doi: 10.1021/acs.jafc.5b00730.
  • Huang, J., and J. H. Brumell. 2014. Bacteria-autophagy interplay: A battle for survival. Nature Reviews Microbiology 12 (2):101–14. doi: 10.1038/nrmicro3160.
  • Humphreys, D., V. Singh, and V. Koronakis. 2016. Inhibition of WAVE regulatory complex activation by a bacterial virulence effector counteracts pathogen phagocytosis. Cell Reports 17 (3):697–707. doi: 10.1016/j.celrep.2016.09.039.
  • Kailasan Vanaja, S., V. A. K. Rathinam, M. K. Atianand, P. Kalantari, B. Skehan, K. A. Fitzgerald, and J. M. Leong. 2014. Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome. Proceedings of the National Academy of Sciences of the United States of America 111 (21):7765–70. doi: 10.1073/pnas.1400075111.
  • Kayagaki, N., M. T. Wong, I. B. Stowe, S. R. Ramani, L. C. Gonzalez, S. Akashi-Takamura, K. Miyake, J. Zhang, W. P. Lee, A. Muszyński, et al. 2013. Noncanonical inflammasome activation by intracellular LPS independent of TLR4. Science (New York, N.Y.) 341 (6151):1246–9. doi: 10.1126/science.1240248.
  • Kenny, B., R. DeVinney, M. Stein, D. J. Reinscheid, E. A. Frey, and B. B. Finlay. 1997. Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cells. Cell 91 (4):511–20. doi: 10.1016/S0092-8674(00)80437-7.
  • Kim, P. K., D. W. Hailey, R. T. Mullen, and J. Lippincott-Schwartz. 2008. Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes. Proceedings of the National Academy of Sciences of the United States of America 105 (52):20567–74. doi: 10.1073/pnas.0810611105.
  • Kim, Y.-G., J.-H. Lee, G. Gwon, S.-I. Kim, J. G. Park, and J. Lee. 2016. Essential oils and eugenols inhibit biofilm formation and the virulence of Escherichia coli O157:H7. Scientific Reports 6:36377. doi: 10.1038/srep36377.
  • Kimmitt, P. T., C. R. Harwood, and M. R. Barer. 2000. Toxin gene expression by shiga toxin-producing Escherichia coli: The role of antibiotics and the bacterial SOS response. Emerging Infectious Diseases 6 (5):458–65. doi: 10.3201/eid0605.000503.
  • Korea, C. G., J. M. Ghigo, and C. Beloin. 2011. The sweet connection: Solving the riddle of multiple sugar-binding fimbrial adhesins in Escherichia coli: Multiple E. coli fimbriae form a versatile arsenal of sugar-binding lectins potentially involved in surface-colonisation and tissue tropism. BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology 33 (4):300–11. doi: 10.1002/bies.201000121.
  • Kraft, C., M. Peter, and K. Hofmann. 2010. Selective autophagy: Ubiquitin-mediated recognition and beyond. Nature Cell Biology 12 (9):836–41. doi: 10.1038/ncb0910-836.
  • Lacombe, A., S. Tadepalli, C.-A. Hwang, and V. C. H. Wu. 2013. Phytochemicals in lowbush wild blueberry inactivate Escherichia coli O157:H7 by damaging its cell membrane. Foodborne Pathogens and Disease 10 (11):944–50. doi: 10.1089/fpd.2013.1504.
  • Lai, Y., K. Riley, A. Cai, et al. 2011. Calpain mediates epithelial cell microvillar effacement by enterohemorrhagic Escherichia coli. Frontiers in Microbiology 2 (222). doi: 10.3389/fmicb.2011.00222.
  • Lee, J.-H., Y.-G. Kim, C.-J. Kim, J.-C. Lee, M. H. Cho, and J. Lee. 2012. Indole-3-acetaldehyde from Rhodococcus sp. BFI 332 inhibits Escherichia coli O157:H7 biofilm formation. Applied Microbiology and Biotechnology 96 (4):1071–8. doi: 10.1007/s00253-012-3881-y.
  • Lee, K.-M., W.-S. Kim, J. Lim, S. Nam, M. Youn, S.-W. Nam, Y. Kim, S.-H. Kim, W. Park, S. Park, et al. 2009. Antipathogenic properties of green tea polyphenol epigallocatechin gallate at concentrations below the MIC against enterohemorrhagic Escherichia coli O157:H7. Journal of Food Protection 72 (2):325–31. doi: 10.4315/0362-028x-72.2.325.
  • Lee, J.-H., Y.-G. Kim, S. Y. Ryu, M. H. Cho, and J. Lee. 2014. Ginkgolic acids and Ginkgo biloba extract inhibit Escherichia coli O157:H7 and Staphylococcus aureus biofilm formation. International Journal of Food Microbiology 174:47–55. doi: 10.1016/j.ijfoodmicro.2013.12.030.
  • Li, W., S. Zhu, J. Li, A. Assa, A. Jundoria, J. Xu, S. Fan, N. T. Eissa, K. J. Tracey, A. E. Sama, et al. 2011. EGCG stimulates autophagy and reduces cytoplasmic HMGB1 levels in endotoxin-stimulated macrophages. Biochemical Pharmacology 81 (9):1152–63. doi: 10.1016/j.bcp.2011.02.015.
  • Liu, R. H. 2004. Potential synergy of phytochemicals in cancer prevention: Mechanism of action. The Journal of Nutrition 134 (12 Suppl):3479S–85S. doi: 10.1093/jn/134.12.3479S.
  • Liu, H., P. Radhakrishnan, L. Magoun, M. Prabu, K. G. Campellone, P. Savage, F. He, C. A. Schiffer, and J. M. Leong. 2002. Point mutants of EHEC intimin that diminish Tir recognition and actin pedestal formation highlight a putative Tir binding pocket. Molecular Microbiology 45 (6):1557–73. doi: 10.1046/j.1365-2958.2002.03137.x.
  • Luetragoon, T., R. Pankla Sranujit, C. Noysang, Y. Thongsri, P. Potup, N. Suphrom, N. Nuengchamnong, and K. Usuwanthim. 2020. Bioactive compounds in Moringa oleifera Lam. Leaves inhibit the pro-inflammatory mediators in lipopolysaccharide-induced human monocyte-derived macrophages. Molecules (Basel, Switzerland) 25 (1): 191. doi: 10.3390/molecules25010191.
  • Ma, C., M. E. Wickham, J. A. Guttman, W. Deng, J. Walker, K. L. Madsen, K. Jacobson, W. A. Vogl, B. B. Finlay, B. A. Vallance, et al. 2006. Citrobacter rodentium infection causes both mitochondrial dysfunction and intestinal epithelial barrier disruption in vivo: Role of mitochondrial associated protein (Map). Cellular Microbiology 8 (10):1669–86. doi: 10.1111/j.1462-5822.2006.00741.x.
  • Man, S. M. 2018. Inflammasomes in the gastrointestinal tract: Infection, cancer and gut microbiota homeostasis. Nature Reviews Gastroenterology & Hepatology 15 (12):721–37. doi: 10.1038/s41575-018-0054-1.
  • Man, S. M., R. Karki, and T. D. Kanneganti. 2016. DNA-sensing inflammasomes: Regulation of bacterial host defense and the gut microbiota. Pathogens and Disease 74 (4):ftw028. doi: 10.1093/femspd/ftw028.
  • Marchès, O., V. Covarelli, S. Dahan, C. Cougoule, P. Bhatta, G. Frankel, and E. Caron. 2008. EspJ of enteropathogenic and enterohaemorrhagic Escherichia coli inhibits opsono-phagocytosis. Cellular Microbiology 10 (5):1104–15. doi: 10.1111/j.1462-5822.2007.01112.x.
  • McIlwain, D. R., T. Berger, and T. W. Mak. 2013. Caspase functions in cell death and disease. Cold Spring Harbor Perspectives in Biology 5 (4):a008656. doi: 10.1101/cshperspect.a008656.
  • Mead, P. S., and P. M. Griffin. 1998. Escherichia coli O157:H7. Lancet (London, England) 352 (9135):1207–12. doi: 10.1016/S0140-6736(98)01267-7.
  • Medellin-Pena, M. J., and M. W. Griffiths. 2009. Effect of molecules secreted by Lactobacillus acidophilus strain La-5 on Escherichia coli O157:H7 colonization. Applied and Environmental Microbiology 75 (4):1165–72. doi: 10.1128/AEM.01651-08.
  • Mogensen, T. H. 2009. Pathogen recognition and inflammatory signaling in innate immune defenses. Clinical Microbiology Reviews 22 (2):240–73. doi: 10.1128/CMR.00046-08.
  • Mohsin, M., S. Guenther, P. Schierack, K. Tedin, and L. H. Wieler. 2015. Probiotic Escherichia coli Nissle 1917 reduces growth, Shiga toxin expression, release and thus cytotoxicity of enterohemorrhagic Escherichia coli. International Journal of Medical Microbiology 305 (1):20–6. doi: 10.1016/j.ijmm.2014.10.003.
  • Morikawa, H., M. Kim, H. Mimuro, C. Punginelli, T. Koyama, S. Nagai, A. Miyawaki, K. Iwai, and C. Sasakawa. 2010. The bacterial effector Cif interferes with SCF ubiquitin ligase function by inhibiting deneddylation of Cullin1. Biochemical and Biophysical Research Communications 401 (2):268–74. doi: 10.1016/j.bbrc.2010.09.048.
  • Morita-Ishihara, T., M. Miura, S. Iyoda, H. Izumiya, H. Watanabe, M. Ohnishi, and J. Terajima. 2013. EspO1-2 regulates EspM2-mediated RhoA activity to stabilize formation of focal adhesions in enterohemorrhagic Escherichia coli-infected host cells. PLoS One 8 (2):e55960. doi: 10.1371/journal.pone.0055960.
  • Morselli, E., M. C. Maiuri, M. Markaki, E. Megalou, A. Pasparaki, K. Palikaras, A. Criollo, L. Galluzzi, S. A. Malik, I. Vitale, et al. 2010. Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death & Disease 1:e10. doi: 10.1038/cddis.2009.8.
  • Mousnier, A., A. D. Whale, S. Schüller, J. M. Leong, A. D. Phillips, and G. Frankel. 2008. Cortactin recruitment by enterohemorrhagic Escherichia coli O157:H7 during infection in vitro and ex vivo. Infection and Immunity 76 (10):4669–76. doi: 10.1128/IAI.00140-08.
  • Nadler, C., K. Baruch, S. Kobi, E. Mills, G. Haviv, M. Farago, I. Alkalay, S. Bartfeld, T. F. Meyer, Y. Ben-Neriah, et al. 2010. The type III secretion effector NleE inhibits NF-kappaB activation. PLoS Pathogens 6 (1):e1000743. doi: 10.1371/journal.ppat.1000743.
  • Nagl, M., L. Kacani, B. Müllauer, E.-M. Lemberger, H. Stoiber, G. M. Sprinzl, H. Schennach, and M. P. Dierich. 2002. Phagocytosis and killing of bacteria by professional phagocytes and dendritic cells. Clinical and Diagnostic Laboratory Immunology 9 (6):1165–8. doi: 10.1128/cdli.9.6.1165-1168.2002.
  • Newton, H. J., J. S. Pearson, L. Badea, M. Kelly, M. Lucas, G. Holloway, K. M. Wagstaff, M. A. Dunstone, J. Sloan, J. C. Whisstock, et al. 2010. The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65. PLoS Pathogens 6 (5):e1000898. doi: 10.1371/journal.ppat.1000898.
  • Nguyen, Y., and V. Sperandio. 2012. Enterohemorrhagic E. coli (EHEC) pathogenesis. Frontiers in Cellular and Infection Microbiology 2 (90). doi: 10.3389/fcimb.2012.00090.
  • Noda, S., S. Tanabe, and T. Suzuki. 2012. Differential effects of flavonoids on barrier integrity in human intestinal Caco-2 cells. Journal of Agricultural and Food Chemistry 60 (18):4628–33. doi: 10.1021/jf300382h.
  • Nougayrede, J. P., and M. S. Donnenberg. 2004. Enteropathogenic Escherichia coli EspF is targeted to mitochondria and is required to initiate the mitochondrial death pathway. Cellular Microbiology 6 (11):1097–111. doi: 10.1111/j.1462-5822.2004.00421.x.
  • Nougayrède, J. P., M. Boury, C. Tasca, O. Marchès, A. Milon, E. Oswald, and J. De Rycke. 2001. Type III secretion-dependent cell cycle block caused in HeLa cells by enteropathogenic Escherichia coli O103. Infection and Immunity 69 (11):6785–95. doi: 10.1128/IAI.69.11.6785-6795.2001.
  • Ortiz, Y., A. García-Heredia, A. Merino-Mascorro, S. García, L. Solís-Soto, and N. Heredia. 2021. Natural and synthetic antimicrobials reduce adherence of enteroaggregative and enterohemorrhagic Escherichia coli to epithelial cells. PLoS One 16 (5):e0251096. doi: 10.1371/journal.pone.0251096.
  • Pachathundikandi, K., and S. Backert. 2018. Heptose 1,7-bisphosphate directed TIFA oligomerization: A novel PAMP-recognizing signaling platform in the control of bacterial infections. Gastroenterology 154 (4):778–83. doi: 10.1053/j.gastro.2018.01.009.
  • Pallett, M. A., V. F. Crepin, N. Serafini, M. Habibzay, O. Kotik, J. Sanchez-Garrido, J. P. Di Santo, A. R. Shenoy, C. N. Berger, G. Frankel, et al. 2017. Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells. Mucosal Immunology 10 (3):602–12. doi: 10.1038/mi.2016.77.
  • Papatheodorou, P., G. Domańska, M. Oxle, J. Mathieu, O. Selchow, B. Kenny, and J. Rassow. 2006. The enteropathogenic Escherichia coli (EPEC) Map effector is imported into the mitochondrial matrix by the TOM/Hsp70 system and alters organelle morphology. Cellular Microbiology 8 (4):677–89. doi: 10.1111/j.1462-5822.2005.00660.x.
  • Park, B. S., and J. O. Lee. 2013. Recognition of lipopolysaccharide pattern by TLR4 complexes. Experimental & Molecular Medicine 45:e66. doi: 10.1038/emm.2013.97.
  • Paton, A. W., R. Morona, and J. C. Paton. 2000. A new biological agent for treatment of Shiga toxigenic Escherichia coli infections and dysentery in humans. Nature Medicine 6 (3):265–70. doi: 10.1038/73111.
  • Peng, M., X. Zhao, and D. Biswas. 2017. Polyphenols and tri-terpenoids from Olea europaea L. in alleviation of enteric pathogen infections through limiting bacterial virulence and attenuating inflammation. Journal of Functional Foods 36:132–43. doi: 10.1016/j.jff.2017.06.059.
  • Platnich, J. M., H. Chung, A. Lau, C. F. Sandall, A. Bondzi-Simpson, H.-M. Chen, T. Komada, A. C. Trotman-Grant, J. R. Brandelli, J. Chun, et al. 2018. Shiga toxin/lipopolysaccharide activates caspase-4 and gasdermin D to trigger mitochondrial reactive oxygen species upstream of the NLRP3 inflammasome. Cell Reports 25 (6):1525–36. e1527. doi: 10.1016/j.celrep.2018.09.071.
  • Psahoulia, F. H., S. Moumtzi, M. L. Roberts, T. Sasazuki, S. Shirasawa, and A. Pintzas. 2007. Quercetin mediates preferential degradation of oncogenic Ras and causes autophagy in Ha-RAS-transformed human colon cells. Carcinogenesis 28 (5):1021–31. doi: 10.1093/carcin/bgl232.
  • Putaala, H., T. Salusjärvi, M. Nordström, M. Saarinen, A. C. Ouwehand, E. Bech Hansen, and N. Rautonen. 2008. Effect of four probiotic strains and Escherichia coli O157:H7 on tight junction integrity and cyclo-oxygenase expression. Research in Microbiology 159 (9–10):692–8. doi: 10.1016/j.resmic.2008.08.002.
  • Raymond, B., J. C. Young, M. Pallett, R. G. Endres, A. Clements, and G. Frankel. 2013. Subversion of trafficking, apoptosis, and innate immunity by type III secretion system effectors. Trends in Microbiology 21 (8):430–41. doi: 10.1016/j.tim.2013.06.008.
  • Roe, A. J., L. Tysall, T. Dransfield, D. Wang, D. Fraser-Pitt, A. Mahajan, C. Constandinou, N. Inglis, A. Downing, R. Talbot, et al. 2007. Analysis of the expression, regulation and export of NleA-E in Escherichia coli O157 : H7. Microbiology (Reading, England) 153 (Pt 5):1350–60. doi: 10.1099/mic.0.2006/003707-0.
  • Rosenshine, I., S. Ruschkowski, M. Stein, D. J. Reinscheid, S. D. Mills, and B. B. Finlay. 1996. A pathogenic bacterium triggers epithelial signals to form a functional bacterial receptor that mediates actin pseudopod formation. EMBO Journal 15 (11):2613–24. doi: 10.1002/j.1460-2075.1996.tb00621.x.
  • Ross, S. A., J. A. Lane, M. Kilcoyne, L. Joshi, and R. M. Hickey. 2016. Defatted bovine milk fat globule membrane inhibits association of enterohaemorrhagic Escherichia coli O157: H7 with human HT-29 cells. International Dairy Journal 59:36–43. doi: 10.1016/j.idairyj.2016.03.001.
  • Roxas, J. L., A. Koutsouris, A. Bellmeyer, S. Tesfay, S. Royan, K. Falzari, A. Harris, H. Cheng, K. J. Rhee, G. Hecht, et al. 2010. Enterohemorrhagic E. coli alters murine intestinal epithelial tight junction protein expression and barrier function in a Shiga toxin independent manner. Laboratory Investigation; a Journal of Technical Methods and Pathology 90 (8):1152–68. doi: 10.1038/labinvest.2010.91.
  • Shaner, N. C., J. W. Sanger, and J. M. Sanger. 2005. Actin and alpha-actinin dynamics in the adhesion and motility of EPEC and EHEC on host cells. Cell Motility and the Cytoskeleton 60 (2):104–20. doi: 10.1002/cm.20047.
  • Sheng, L., B. Rasco, and M. J. Zhu. 2016. Cinnamon oil inhibits shiga toxin type 2 phage induction and shiga toxin type 2 production in Escherichia coli O157:H7. Applied and Environmental Microbiology 82 (22):6531–40. doi: 10.1128/AEM.01702-16.
  • Shi, J., Y. Zhao, Y. Wang, W. Gao, J. Ding, P. Li, L. Hu, and F. Shao. 2014. Inflammatory caspases are innate immune receptors for intracellular LPS. Nature 514 (7521):187–92. doi: 10.1038/nature13683.
  • Shigeshiro, M., S. Tanabe, and T. Suzuki. 2013. Dietary polyphenols modulate intestinal barrier defects and inflammation in a murine model of colitis. Journal of Functional Foods 5 (2):949–55. doi: 10.1016/j.jff.2013.02.008.
  • Shoaf, K., G. L. Mulvey, G. D. Armstrong, and R. W. Hutkins. 2006. Prebiotic galactooligosaccharides reduce adherence of enteropathogenic Escherichia coli to tissue culture cells. Infection and Immunity 74 (12):6920–8. doi: 10.1128/IAI.01030-06.
  • Simovitch, M., H. Sason, S. Cohen, E. E. Zahavi, N. Melamed-Book, A. Weiss, B. Aroeti, and I. Rosenshine. 2010. EspM inhibits pedestal formation by enterohaemorrhagic Escherichia coli and enteropathogenic E. coli and disrupts the architecture of a polarized epithelial monolayer. Cellular Microbiology 12 (4):489–505. doi: 10.1111/j.1462-5822.2009.01410.x.
  • Smith, W. E., A. V. Kane, S. T. Campbell, D. W. K. Acheson, B. H. Cochran, and C. M. Thorpe. 2003. Shiga toxin 1 triggers a ribotoxic stress response leading to p38 and JNK activation and induction of apoptosis in intestinal epithelial cells. Infection and Immunity 71 (3):1497–504. doi: 10.1128/IAI.71.3.1497-1504.2003.
  • Song, T., K. Li, W. Zhou, J. Zhou, Y. Jin, H. Dai, T. Xu, M. Hu, H. Ren, J. Yue, et al. 2017. A type III effector NleF from EHEC inhibits epithelial inflammatory cell death by targeting caspase-4. BioMed Research International 2017:4101745. doi: 10.1155/2017/4101745.
  • Subramanian, M., M. Goswami, S. Chakraborty, and N. Jawali. 2014. Resveratrol induced inhibition of Escherichia coli proceeds via membrane oxidation and independent of diffusible reactive oxygen species generation. Redox Biology 2:865–72. doi: 10.1016/j.redox.2014.06.007.
  • Subramanian, M., S. Soundar, and S. Mangoli. 2016. DNA damage is a late event in resveratrol-mediated inhibition of Escherichia coli. Free Radical Research 50 (7):708–19. doi: 10.3109/10715762.2016.1169404.
  • Thévenot, J., C. Cordonnier, A. Rougeron, O. Le Goff, H. T. T. Nguyen, S. Denis, M. Alric, V. Livrelli, and S. Blanquet-Diot. 2015. Enterohemorrhagic Escherichia coli infection has donor-dependent effect on human gut microbiota and may be antagonized by probiotic yeast during interaction with Peyer's patches. Applied Microbiology and Biotechnology 99 (21):9097–110. doi: 10.1007/s00253-015-6704-0.
  • Thomas, C. M., and J. Versalovic. 2010. Probiotics-host communication: Modulation of signaling pathways in the intestine. Gut Microbes 1 (3):148–63. doi: 10.4161/gmic.1.3.11712.
  • Thurston, T. L. M., G. Ryzhakov, S. Bloor, N. von Muhlinen, and F. Randow. 2009. The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria. Nature Immunology 10 (11):1215–21. doi: 10.1038/ni.1800.
  • Tobe, T., S. A. Beatson, H. Taniguchi, H. Abe, C. M. Bailey, A. Fivian, R. Younis, S. Matthews, O. Marches, G. Frankel, et al. 2006. An extensive repertoire of type III secretion effectors in Escherichia coli O157 and the role of lambdoid phages in their dissemination. Proceedings of the National Academy of Sciences of the United States of America 103 (40):14941–6. doi: 10.1073/pnas.0604891103.
  • Tree, J. J., E. B. Wolfson, D. Wang, A. J. Roe, and D. L. Gally. 2009. Controlling injection: Regulation of type III secretion in enterohaemorrhagic Escherichia coli. Trends in Microbiology 17 (8):361–70. doi: 10.1016/j.tim.2009.06.001.
  • Tyska, M. J. 2016. Brush border destruction by enterohemorrhagic Escherichia coli (EHEC): New insights from organoid culture. Cellular and Molecular Gastroenterology and Hepatology 2 (1):7–8. doi: 10.1016/j.jcmgh.2015.11.002.
  • Ultee, A., M. H. Bennik, and R. Moezelaar. 2002. The phenolic hydroxyl group of carvacrol is essential for action against the food-borne pathogen Bacillus cereus. Applied and Environmental Microbiology 68 (4):1561–8. doi: 10.1128/AEM.68.4.1561-1568.2002.
  • Vahid, F., H. Zand, E. Nosrat-Mirshekarlou, R. Najafi, and A. Hekmatdoost. 2015. The role dietary of bioactive compounds on the regulation of histone acetylases and deacetylases: A review. Gene 562 (1):8–15. doi: 10.1016/j.gene.2015.02.045.
  • Vikram, A., G. K. Jayaprakasha, R. M. Uckoo, and B. S. Patil. 2013. Inhibition of Escherichia coli O157:H7 motility and biofilm by β-sitosterol glucoside. Biochimica et Biophysica Acta 1830 (11):5219–28. doi: 10.1016/j.bbagen.2013.07.022.
  • Viswanathan, V. K., A. Koutsouris, S. Lukic, M. Pilkinton, I. Simonovic, M. Simonovic, and G. Hecht. 2004. Comparative analysis of EspF from enteropathogenic and enterohemorrhagic Escherichia coli in alteration of epithelial barrier function. Infection and Immunity 72 (6):3218–27. doi: 10.1128/IAI.72.6.3218-3227.2004.
  • Wan, F., A. Weaver, X. Gao, M. Bern, P. R. Hardwidge, and M. J. Lenardo. 2011. IKKβ phosphorylation regulates RPS3 nuclear translocation and NF-κB function during infection with Escherichia coli strain O157:H7 . Nature Immunology 12 (4):335–43. doi: 10.1038/ni.2007.
  • Wang, X., Y. Du, Y. Hua, et al. 2017. The EspF N-terminal of enterohemorrhagic Escherichia coli O157:H7 EDL933w imparts stronger toxicity effects on HT-29 cells than the C-terminal. Frontiers in Cellular and Infection Microbiology 7 (410). doi: 10.3389/fcimb.2017.00410.
  • Wang, K., R. Liu, J. Li, J. Mao, Y. Lei, J. Wu, J. Zeng, T. Zhang, H. Wu, L. Chen, et al. 2011. Quercetin induces protective autophagy in gastric cancer cells: Involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling. Autophagy 7 (9):966–78. doi: 10.4161/auto.7.9.15863.
  • Wang, H., Y. Xue, H. Zhang, Y. Huang, G. Yang, M. Du, and M.-J. Zhu. 2013. Dietary grape seed extract ameliorates symptoms of inflammatory bowel disease in IL10-deficient mice. Molecular Nutrition & Food Research 57 (12):2253–7. doi: 10.1002/mnfr.201300146.
  • Wang, G., Y. Zhang, X. Song, Y. Xia, P. F.-H. Lai, and L. Ai. 2019. Lactobacillus casei LC2W can inhibit the colonization of Escherichia coli O157:H7 in vivo and reduce the severity of colitis. Food & Function 10 (9):5843–52. doi: 10.1039/c9fo01390c.
  • Weiss, S. M., M. Ladwein, D. Schmidt, J. Ehinger, S. Lommel, K. Städing, U. Beutling, A. Disanza, R. Frank, L. Jänsch, et al. 2009. IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation. Cell Host & Microbe 5 (3):244–58. doi: 10.1016/j.chom.2009.02.003.
  • Winkler, P., D. Ghadimi, J. Schrezenmeir, and J.-P. Kraehenbuhl. 2007. Molecular and cellular basis of microflora-host interactions. The Journal of Nutrition 137 (3 Suppl 2):756S–72S. doi: 10.1093/jn/137.3.756S.
  • Wu, R. Y., M. Abdullah, P. Määttänen, A. V. C. Pilar, E. Scruten, K. C. Johnson-Henry, S. Napper, C. O'Brien, N. L. Jones, P. M. Sherman, et al. 2017. Protein kinase C δ signaling is required for dietary prebiotic-induced strengthening of intestinal epithelial barrier function . Scientific Reports 7:40820. doi: 10.1038/srep40820.
  • Wu, Z., D. Milton, P. Nybom, A. Sjö, and K. E. Magnusson. 1996. Vibrio cholerae hemagglutinin/protease (HA/protease) causes morphological changes in cultured epithelial cells and perturbs their paracellular barrier function. Microbial Pathogenesis 21 (2):111–23. doi: 10.1006/mpat.1996.0047.
  • Wu, Z., P. Nybom, and K. E. Magnusson. 2000. Distinct effects of Vibrio cholerae haemagglutinin/protease on the structure and localization of the tight junction-associated proteins occludin and ZO-1. Cellular Microbiology 2 (1):11–7. doi: 10.1046/j.1462-5822.2000.00025.x.
  • Xiong, L.-G., Y.-J. Chen, J.-W. Tong, J.-A. Huang, J. Li, Y.-S. Gong, and Z.-H. Liu. 2017. Tea polyphenol epigallocatechin gallate inhibits Escherichia coli by increasing endogenous oxidative stress. Food Chemistry 217:196–204. doi: 10.1016/j.foodchem.2016.08.098.
  • Xue, Y., M. Du, H. Sheng, C. J. Hovde, and M.-J. Zhu. 2017. Escherichia coli O157:H7 suppresses host autophagy and promotes epithelial adhesion via Tir-mediated and cAMP-independent activation of protein kinase A. Cell Death Discovery 3:17055. doi: 10.1038/cddiscovery.2017.55.
  • Xue, Y., M. Du, and M. J. Zhu. 2019. Raspberry extract prevents NLRP3 inflammasome activation in gut epithelial cells induced by pathogenic Escherichia coli. Journal of Functional Foods 56:224–31. doi: 10.1016/j.jff.2019.03.005.
  • Xue, Y., M. Du, and M. J. Zhu. 2017. Quercetin suppresses NLRP3 inflammasome activation in epithelial cells triggered by Escherichia coli O157:H7. Free Radical Biology & Medicine 108:760–9. doi: 10.1016/j.freeradbiomed.2017.05.003.
  • Xue, Y., M. Du, and M. J. Zhu. 2018. Quercetin prevents Escherichia coli O157:H7 adhesion to epithelial cells via suppressing focal adhesions. Frontiers in Microbiology 9:3278. doi: 10.3389/fmicb.2018.03278.
  • Xue, Y., D. Enosi Tuipulotu, W. H. Tan, C. Kay, and S. M. Man. 2019. Emerging activators and regulators of Inflammasomes and Pyroptosis. Trends in Immunology 40 (11):1035–52. doi: 10.1016/j.it.2019.09.005.
  • Yan, D., H. Quan, L. Wang, F. Liu, H. Liu, J. Chen, X. Cao, and B. Ge. 2013. Enteropathogenic Escherichia coli Tir recruits cellular SHP-2 through ITIM motifs to suppress host immune response. Cellular Signalling 25 (9):1887–94. doi: 10.1016/j.cellsig.2013.05.020.
  • Yang, G., S. Bibi, M. Du, T. Suzuki, and M.-J. Zhu. 2017. Regulation of the intestinal tight junction by natural polyphenols: A mechanistic perspective. Critical Reviews in Food Science and Nutrition 57 (18):3830–9. doi: 10.1080/10408398.2016.1152230.
  • Yang, J., C. B. Tang, J. Xiao, W. F. Du, and R. Li. 2018. Influences of epigallocatechin gallate and citric acid on Escherichia coli O157:H7 toxin gene expression and virulence-associated stress response. Letters in Applied Microbiology 67 (5):435–41. doi: 10.1111/lam.13058.
  • Yen, H., T. Ooka, A. Iguchi, T. Hayashi, N. Sugimoto, and T. Tobe. 2010. NleC, a type III secretion protease, compromises NF-κB activation by targeting p65/RelA . PLoS Pathogens 6 (12):e1001231. doi: 10.1371/journal.ppat.1001231.
  • Yen, H., N. Sugimoto, and T. Tobe. 2015. Enteropathogenic Escherichia coli uses NleA to inhibit NLRP3 inflammasome activation. PLoS Pathogens 11 (9):e1005121. doi: 10.1371/journal.ppat.1005121.
  • Zhang, L., X. Ding, J. Cui, H. Xu, J. Chen, Y.-N. Gong, L. Hu, Y. Zhou, J. Ge, Q. Lu, et al. 2011. Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation. Nature 481 (7380):204–8. doi: 10.1038/nature10690.
  • Zhang, X., A. D. McDaniel, L. E. Wolf, G. T. Keusch, M. K. Waldor, and D. W. Acheson. 2000. Quinolone antibiotics induce Shiga toxin-encoding bacteriophages, toxin production, and death in mice. The Journal of Infectious Diseases 181 (2):664–70. doi: 10.1086/315239.
  • Zhu, M.-J., Y. Kang, Y. Xue, X. Liang, M. P. G. García, D. Rodgers, D. R. Kagel, and M. Du. 2018. Red raspberries suppress NLRP3 inflammasome and attenuate metabolic abnormalities in diet-induced obese mice. The Journal of Nutritional Biochemistry 53:96–103. doi: 10.1016/j.jnutbio.2017.10.012.
  • Zhu, M. J., S. A. Olsen, L. Sheng, Y. Xue, and W. Yue. 2015. Antimicrobial efficacy of grape seed extract against Escherichia coli O157: H7 growth, motility and Shiga toxin production. Food Control 51:177–82. doi: 10.1016/j.foodcont.2014.11.024.
  • Zhu, M. J., X. Sun, and M. Du. 2018. AMPK in regulation of apical junctions and barrier function of intestinal epithelium. Tissue Barriers 6 (2):1–13. doi: 10.1080/21688370.2018.1487249.

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