420
Views
17
CrossRef citations to date
0
Altmetric
Reviews

Central obesity accelerates leukocyte telomere length (LTL) shortening in apparently healthy adults: A systematic review and meta-analysis

, , , &

References

  • Ajaykumar, A., H. Soudeyns, F. Kakkar, J. Brophy, A. Bitnun, A. Alimenti, D. M. Money, A. Y. Albert, and H. C. Côté. 2015. Maternal smoking during pregnancy exerts greater influence on infant leukocyte telomere length at Birth than in Utero HIV or antiretroviral drug exposure. Canadian Journal of Infectious Diseases and Medical Microbiology 26:36B–7B.
  • Armani, C., N. Botto, M. G. Andreassi, and E. Centaro. 2013. Molecular markers of cardiovascular damage in hypertension. Current Pharmaceutical Design 19 (13):2341–50. doi:10.2174/1381612811319130002.
  • Ashwell, M., and S. Gibson. 2009. Waist to height ratio is a simple and effective obesity screening tool for cardiovascular risk factors: Analysis of data from the British National Diet and Nutrition Survey of adults aged 19-64 years. Obesity Facts 2 (2):97–103. doi: 10.1159/000203363.
  • Babizhayev, M. A., E. L. Savel’yeva, S. N. Moskvina, and Y. E. Yegorov. 2011. Telomere length is a biomarker of cumulative oxidative stress, biologic age, and an independent predictor of survival and therapeutic treatment requirement associated with smoking behavior. American Journal of Therapeutics 18 (6):e209–e226. doi: 10.1097/MJT.0b013e3181cf8ebb.
  • Bao, Y., J. Prescott, C. Yuan, M. Zhang, P. Kraft, A. Babic, V. Morales-Oyarvide, Z. R. Qian, J. E. Buring, B. B. Cochrane, et al. 2017. Leucocyte telomere length, genetic variants at the TERT gene region and risk of pancreatic cancer. Gut 66 (6):1116–22. doi: 10.1136/gutjnl-2016-312510.
  • Bekaert, S., T. De Meyer, E. R. Rietzschel, M. L. De Buyzere, D. De Bacquer, M. Langlois, P. Segers, L. Cooman, P. Van Damme, P. Cassiman, Asklepios investigators, et al. 2007. Telomere length and cardiovascular risk factors in a middle-aged population free of overt cardiovascular disease. Aging Cell 6 (5):639–47. doi: 10.1111/j.1474-9726.2007.00321.x.
  • Bloom, S. I., A. Tuluca, S. J. Ives, and T. H. Reynolds. 2020. High-fat diet induced obesity and age influence the telomere shelterin complex and telomerase gene expression in mouse adipose tissue. Physiological Reports 8 (11):e14461. doi: 10.14814/phy2.14461.
  • Borruel, S., J. F. Moltó, M. Alpañés, E. Fernández-Durán, F. Álvarez-Blasco, M. Luque-Ramírez, and H. F. Escobar-Morreale. 2014. Surrogate markers of visceral adiposity in young adults: Waist circumference and body mass index are more accurate than waist hip ratio, model of adipose distribution and visceral adiposity index. PLoS One 9 (12):e114112. doi: 10.1371/journal.pone.0114112.
  • Bosomworth, N. J. 2019. Normal-weight central obesity: Unique hazard of the toxic waist. Canadian Family Physician Medecin de Famille Canadien 65 (6):399–408.
  • Broer, L., J. Raschenberger, J. Deelen, M. Mangino, V. Codd, K. H. Pietiläinen, E. Albrecht, N. Amin, M. Beekman, A. J. M. de Craen, et al. 2014. Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants. European Journal of Epidemiology 29 (9):629–38. doi: 10.1007/s10654-014-9940-1.
  • Cassidy, A., I. De Vivo, Y. Liu, J. Han, J. Prescott, D. J. Hunter, and E. B. Rimm. 2010. Associations between diet, lifestyle factors, and telomere length in women. The American Journal of Clinical Nutrition 91 (5):1273–80. doi: 10.3945/ajcn.2009.28947.
  • Chen, S., F. Yeh, J. Lin, T. Matsuguchi, E. Blackburn, E. T. Lee, B. V. Howard, and J. Zhao. 2014. Short leukocyte telomere length is associated with obesity in american indians: The strong heart family study. Aging 6 (5):380–9. doi: 10.18632/aging.100664.
  • Cherkas, L. F., J. L. Hunkin, B. S. Kato, J. B. Richards, J. P. Gardner, G. L. Surdulescu, M. Kimura, X. Lu, T. D. Spector, and A. Aviv. 2008. The association between physical activity in leisure time and leukocyte telomere length. Archives of Internal Medicine 168 (2):154–8. doi: 10.1001/archinternmed.2007.39.
  • Cho, C. E., S. Taesuwan, O. V. Malysheva, E. Bender, N. F. Tulchinsky, J. Yan, J. L. Sutter, and M. A. Caudill. 2017. Trimethylamine-N-oxide (TMAO) response to animal source foods varies among healthy young men and is influenced by their gut microbiota composition: A randomized controlled trial. Molecular Nutrition & Food Research 61 (1):1600324. doi: 10.1002/mnfr.201600324.
  • Dankel, S. J., J. P. Loenneke, and P. D. Loprinzi. 2017. The impact of overweight/obesity duration and physical activity on telomere length: An application of the WATCH paradigm. Obesity Research & Clinical Practice 11 (2):247–52. doi: 10.1016/j.orcp.2016.11.002.
  • De La Serna, S., P. Sáez-Carlin, O. Cano-Valderrama, J. Dziakova, I. Dominguez-Serrano, S. García-Martínez, D. González-Gamo, G. Mateos, T. Fernández-Marcelo, A. Barabash, et al. 2019. Obesity and telomere status influence the prognosis of colorectal cancer patients. Obesity Surgery 29 (5):403–11.
  • Deelen, J., M. Beekman, V. Codd, S. Trompet, L. Broer, S. Hägg, K. Fischer, P. E. Thijssen, H. E. D. Suchiman, I. Postmus, et al. 2014. Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers. International Journal of Epidemiology 43 (3):878–86. doi: 10.1093/ije/dyt267.
  • Dlouha, D., J. Maluskova, I. K. Lesna, V. Lanska, and J. Hubacek. 2014. Comparison of the relative telomere length measured in leukocytes and eleven different human tissues. Physiological Research 63:S343.
  • Du, M., J. Prescott, M. C. Cornelis, S. E. Hankinson, E. Giovannucci, P. Kraft, and I. de Vivo. 2013. Genetic predisposition to higher body mass index or type 2 diabetes and leukocyte telomere length in the nurses’ health study. PLoS ONE 8 (2):e52240. doi: 10.1371/journal.pone.0052240.
  • Fernández-Castilla, B., A. M. Aloe, L. Declercq, L. Jamshidi, P. Onghena, S. N. Beretvas, and W. Van den Noortgate. 2019. Concealed correlations meta-analysis: A new method for synthesizing standardized regression coefficients. Behavior Research Methods 51 (1):316–31. doi: 10.3758/s13428-018-1123-7.
  • García-Calzón, S., G. Zalba, M. Ruiz-Canela, N. Shivappa, J. R. Hébert, J. A. Martínez, M. Fitó, E. Gómez-Gracia, M. A. Martínez-González, and A. Marti. 2015. Dietary inflammatory index and telomere length in subjects with a high cardiovascular disease risk from the PREDIMED-NAVARRA study: Cross-sectional and longitudinal analyses over 5 y. The American Journal of Clinical Nutrition 102 (4):897–904. doi: 10.3945/ajcn.115.116863.
  • Gielen, M., G. J. Hageman, E. E. Antoniou, K. Nordfjall, M. Mangino, M. Balasubramanyam, T. De Meyer, A. E. Hendricks, E. J. Giltay, S. C. Hunt, TELOMAAS group, et al. 2018. Body mass index is negatively associated with telomere length: A collaborative cross-sectional meta-analysis of 87 observational studies. The American Journal of Clinical Nutrition 108 (3):453–75. doi: 10.1093/ajcn/nqy107.
  • Grieshober, L., J. Wactawski-Wende, R. H. Blair, L. Mu, L. Preus, J. Nie, J. Han, J. R. Meliker, T. Rohan, and H. M. Ochs-Balcom. 2017. Telomere length genetic risk score is associated with breast cancer risk. Cancer Research 77 (Supplement 13):1288.
  • Hardikar, S., X. Song, R. A. Risques, T. J. Montine, C. Duggan, P. L. Blount, B. J. Reid, G. L. Anderson, M. Kratz, E. White, et al. 2015. Obesity and inflammation markers in relation to leukocyte telomere length in a cross-sectional study of persons with Barrett’s esophagus. BMC Obesity 2 (1):32–40. doi: 10.1186/s40608-015-0063-3.
  • Higgins, J. P., and S. G. Thompson. 2002. Quantifying heterogeneity in a meta-analysis. Statistics in Medicine 21 (11):1539–58. doi: 10.1002/sim.1186.
  • Hunt, S. C., M. E. B. Hansen, S. Verhulst, M. A. McQuillan, W. Beggs, T. P. Lai, G. G. Mokone, S. W. Mpoloka, D. W. Meskel, G. Belay, et al. 2020. Genetics and geography of leukocyte telomere length in sub-Saharan Africans. Human Molecular Genetics 29 (18):3014–20. doi: 10.1093/hmg/ddaa187.
  • Khan, R. J., S. Y. Gebreab, A. Gaye, P. R. Crespo, R. Xu, and S. K. Davis. 2019. Associations of smoking indicators and cotinine levels with telomere length: National Health and Nutrition Examination Survey. Preventive Medicine Reports 15:100895. doi: 10.1016/j.pmedr.2019.100895.
  • Koriath, M., C. Mueller, S. Blankenberg, and T. Zeller. 2018. Relation of relative telomere length and cardiovascular disease in the population. European Heart Journal 39 (suppl_1):P6547. doi: 10.1093/eurheartj/ehy566.P6547.
  • Mazidi, M., A. P. Kengne, A. Sahebkar, and M. Banach. 2018. Telomere length is associated with cardiometabolic factors in US Adults. Angiology 69 (2):164–9. doi: 10.1177/0003319717712860.
  • Moher, D., A. Liberati, J. Tetzlaff, and D. G. Altman, PRISMA Group. 2009. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. Annals of Internal Medicine 151 (4):264–9. doi: 10.7326/0003-4819-151-4-200908180-00135.
  • Ng, S. F., R. C. Lin, C. A. Maloney, N. A. Youngson, J. A. Owens, and M. J. Morris. 2014. Paternal high-fat diet consumption induces common changes in the transcriptomes of retroperitoneal adipose and pancreatic islet tissues in female rat offspring. The FASEB Journal 28 (4):1830–41. doi: 10.1096/fj.13-244046.
  • Njajou, O. T., R. M. Cawthon, E. H. Blackburn, T. B. Harris, R. Li, J. L. Sanders, A. B. Newman, M. Nalls, S. R. Cummings, and W. C. Hsueh. 2012. Shorter telomeres are associated with obesity and weight gain in the elderly. International Journal of Obesity (2005) 36 (9):1176–9. doi: 10.1038/ijo.2011.196.
  • O’Donovan, A., M. S. Pantell, E. Puterman, F. S. Dhabhar, E. H. Blackburn, K. Yaffe, R. M. Cawthon, P. L. Opresko, W.-C. Hsueh, S. Satterfield, for the Health Aging and Body Composition Study, et al. 2011. Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study. PloS One 6 (5):e19687. doi: 10.1371/journal.pone.0019687.
  • Owolabi, E. O., D. Ter Goon, and O. V. Adeniyi. 2017. Central obesity and normal-weight central obesity among adults attending healthcare facilities in Buffalo City Metropolitan Municipality, South Africa: A cross-sectional study. Journal of Health, Population, and Nutrition 36 (1):54. doi: 10.1186/s41043-017-0133-x.
  • Pavanello, S., M. Hoxha, L. Dioni, P. A. Bertazzi, R. Snenghi, A. Nalesso, S. D. Ferrara, M. Montisci, and A. Baccarelli. 2011. Shortened telomeres in individuals with abuse in alcohol consumption. International Journal of Cancer 129 (4):983–992. doi: 10.1002/ijc.25999.
  • Rezuş, E., A. Burlui, A. Cardoneanu, C. Rezuş, C. Codreanu, M. Pârvu, G. R. Zota, and B. I. Tamba. 2020. Inactivity and skeletal muscle metabolism: A vicious cycle in old age. International Journal of Molecular Sciences 21 (2):592–163. doi: 10.3390/ijms21020592.
  • Riley, R. D., J. P. Higgins, and J. J. Deeks. 2011. Interpretation of random effects meta-analyses. BMJ (Clinical Research ed.) 342:d549. doi: 10.1136/bmj.d549.
  • Salvestrini, V., C. Sell, and A. Lorenzini. 2019. Obesity may accelerate the aging process. Frontiers in Endocrinology 10:266–269. doi: 10.3389/fendo.2019.00266.
  • Santos, A., C. Lopes, J. Guimaraes, and H. Barros. 2005. Central obesity as a major determinant of increased high-sensitivity C-reactive protein in metabolic syndrome. International Journal of Obesity 29 (12):1452–1456. doi: 10.1038/sj.ijo.0803035.
  • Shadyab, A. H., M. J. Lamonte, C. Kooperberg, A. P. Reiner, C. L. Carty, T. M. Manini, L. Hou, C. Di, and A. Z. Lacroix. 2017. Association of accelerometer-measured physical activity with leukocyte telomere length among older women. The Journals of Gerontology: Series A 72 (11):1532–1537. doi: 10.1093/gerona/glx037.
  • Shin, Y. A., and K Y. Lee. 2016. Low estrogen levels and obesity are associated with shorter telomere lengths in pre- and postmenopausal women. Journal of Exercise Rehabilitation 12 (3):238–246. doi: 10.12965/jer.1632584.292.
  • Strandberg, T. E., O. Saijonmaa, R. S. Tilvis, K. H. Pitkälä, A. Y. Strandberg, T. A. Miettinen, and F. Fyhrquist. 2011. Association of telomere length in older men with mortality and midlife body mass index and smoking. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 66A (7):815–820. doi: 10.1093/gerona/glr064.
  • Strandberg, T. E., A. Y. Strandberg, O. Saijonmaa, R. S. Tilvis, K. H. Pitkälä, and F. Fyhrquist. 2012. Association between alcohol consumption in healthy midlife and telomere length in older men. The Helsinki Businessmen Study. European Journal of Epidemiology 27 (10):815–822. doi: 10.1007/s10654-012-9728-0.
  • Wang, J., X. Dong, L. Cao, Y. Sun, Y. Qiu, Y. Zhang, R. Cao, M. Covasa, and L. Zhong. 2016. Association between telomere length and diabetes mellitus: A meta-analysis. The Journal of International Medical Research 44 (6):1156–1173. doi: 10.1177/0300060516667132.
  • Willeit, P., J. Raschenberger, E. E. Heydon, S. Tsimikas, M. Haun, A. Mayr, S. Weger, J. L. Witztum, A. S. Butterworth, J. Willeit, et al. 2014. Leucocyte telomere length and risk of type 2 diabetes mellitus: New prospective cohort study and literature-based meta-analysis. PLoS ONE 9 (11):e112483. doi: 10.1371/journal.pone.0112483.
  • Wulaningsih, W., F. E. C. Serrano, A. Utarini, T. Matsuguchi, and J. Watkins, PILAR Research Network. 2016. Smoking, second-hand smoke exposure and smoking cessation in relation to leukocyte telomere length and mortality. Oncotarget 7 (37):60419–60431. doi: 10.18632/oncotarget.11051.
  • Zgheib, N. K., F. Sleiman, L. Nasreddine, M. Nasrallah, N. Nakhoul, H. Isma’eel, and H. Tamim. 2018. Short telomere length is associated with aging, central obesity, poor sleep and hypertension in lebanese individuals. Aging and Disease 9 (1):77–89. doi: 10.14336/AD.2017.0310.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.