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Review Articles

Gut microbiota as a potential target for developing anti-fatigue foods

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References

  • Adak, A., C. Maity, K. Ghosh, B. R. Pati, and K. C. Mondal. 2013. Dynamics of predominant microbiota in the human gastrointestinal tract and change in luminal enzymes and immunoglobulin profile during high-altitude adaptation. Folia Microbiologica 58 (6):523–8. doi: 10.1007/s12223-013-0241-y.
  • Agus, A., J. Planchais, and H. Sokol. 2018. Gut microbiota regulation of tryptophan metabolism in health and disease. Cell Host & Microbe 23 (6):716–24. doi: 10.1016/j.chom.2018.05.003.
  • Al-Lahham, S. H., M. P. Peppelenbosch, H. Roelofsen, R. J. Vonk, and K. Venema. 2010. Biological effects of propionic acid in humans; metabolism, potential applications and underlying mechanisms. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1801 (11):1175–83. doi: 10.1016/j.bbalip.2010.07.007.
  • Allen, D., and H. Westerblad. 2004. Physiology. Lactic acid-the latest performance-enhancing drug. Science (New York, N.Y.) 305 (5687):1112–3. doi: 10.1126/science.1103078.
  • Bao, L., X. Cai, J. Wang, Y. Zhang, B. Sun, and Y. Li. 2016. Anti-fatigue effects of small molecule oligopeptides isolated from Panax ginseng C. A. Meyer in mice. Nutrients 8 (12):807. doi: 10.3390/nu8120807.
  • Bao, T., Y. Li, J. Xie, Z. Jia, and W. Chen. 2019. Systematic evaluation of polyphenols composition and antioxidant activity of mulberry cultivars subjected to gastrointestinal digestion and gut microbiota fermentation. Journal of Functional Foods 58:338–49. doi: 10.1016/j.jff.2019.05.017.
  • Belluardo, N., H. Westerblad, G. Mudo, A. Casabona, J. Bruton, G. Caniglia, O. Pastoris, F. Grassi, and C. F. Ibanez. 2001. Neuromuscular junction disassembly and muscle fatigue in mice lacking neurotrophin-4. Molecular and Cellular Neurosciences 18 (1):56–67. doi: 10.1006/mcne.2001.1001.
  • Belzer, C., and W. M. de Vos. 2012. Microbes inside-from diversity to function: The case of Akkermansia. The ISME Journal 6 (8):1449–58. doi: 10.1038/ismej.2012.6.
  • Borghi, M., M. Puccetti, M. Pariano, G. Renga, C. Stincardini, M. Ricci, S. Giovagnoli, C. Costantini, and L. Romani. 2020. Tryptophan as a central hub for host/microbial symbiosis. International Journal of Tryptophan Research 13:117864692091975– 6. doi: 10.1177/1178646920955.
  • Carroll, T. J., J. L. Taylor, and S. C. Gandevia. 2017. Recovery of central and peripheral neuromuscular fatigue after exercise. Journal of Applied Physiology (Bethesda, MD. : 1985) 122 (5):1068–76. doi: 10.1152/japplphysiol.00775.2016.
  • Chen, Y.-M., L. Wei, Y.-S. Chiu, Y.-J. Hsu, T.-Y. Tsai, M.-F. Wang, and C.-C. Huang. 2016. Lactobacillus plantarum TWK10 supplementation improves exercise performance and increases muscle mass in mice. Nutrients 8 (4):205. doi: 10.3390/nu8040205.
  • Comai, S., A. Bertazzo, M. Brughera, and S. Crotti. 2020. Tryptophan in health and disease. Advances in Clinical Chemistry 95:165–218. doi: 10.1016/bs.acc.2019.08.005.
  • Cox, L. M., I. Cho, S. A. Young, W. H. K. Anderson, B. J. Waters, S.-C. Hung, Z. Gao, D. Mahana, M. Bihan, A. V. Alekseyenko, et al. 2013. The nonfermentable dietary fiber hydroxypropyl methylcellulose modulates intestinal microbiota. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology 27 (2):692–702. doi: 10.1096/fj.12-219477.
  • Cryan, J. F., and T. G. Dinan. 2012. Mind-altering microorganisms: The impact of the gut microbiota on brain and behaviour. Nature Reviews. Neuroscience 13 (10):701–12. doi: 10.1038/nrn3346.
  • da Silva-Maia, J. K., A. G. Batista, L. C. Correa, G. C. Lima, S. Bogusz Junior, and M. R. Marostica Junior. 2019. Aqueous extract of berry (Plinia jaboticaba) byproduct modulates gut microbiota and maintains the balance on antioxidant defense system in rats. Journal of Food Biochemistry 43 (2):e12705. doi: 10.1111/jfbc.12705.
  • de Oliveira, E. P., R. C. Burini, and A. Jeukendrup. 2014. Gastrointestinal complaints during exercise: Prevalence, etiology, and nutritional recommendations. Sports Medicine 44 (S1):79–85. doi: 10.1007/s40279-014-0153-2.
  • De Preter, V., K. P. Geboes, V. Bulteel, G. Vandermeulen, P. Suenaert, P. Rutgeerts, and K. Verbeke. 2011. Kinetics of butyrate metabolism in the normal colon and in ulcerative colitis: The effects of substrate concentration and carnitine on the β-oxidation pathway. Alimentary Pharmacology & Therapeutics 34 (5):526–32. doi: 10.1111/j.1365-2036.2011.04757.x.
  • Devries, M. C., and S. M. Phillips. 2015. Supplemental protein in support of muscle mass and health: Advantage whey. Journal of Food Science 80 (S1):A8–A15. doi: 10.1111/1750-3841.12802.
  • Dicksved, J., O. Schreiber, B. Willing, J. Petersson, S. Rang, M. Phillipson, L. Holm, and S. Roos. 2012. Lactobacillus reuteri maintains a functional mucosal barrier during DSS treatment despite mucus layer dysfunction. PLoS One 7 (9):e46399 doi: 10.1371/journal.pone.0046399.
  • Dolara, P., C. Luceri, C. De Filippo, A. P. Femia, L. Giovannelli, G. Caderni, C. Cecchini, S. Silvi, C. Orpianesi, and A. Cresci. 2005. Red wine polyphenols influence carcinogenesis, intestinal microflora, oxidative damage and gene expression profiles of colonic mucosa in F344 rats. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 591 (1-2):237–46. doi: 10.1016/j.mrfmmm.2005.04.022.
  • Dong, H. B., Y. X. Sun, Y. F. Duan, H. Li, Y. Li, Q. S. Liu, W. H. Wang, and J. S. Zhang. 2020. The effect of teprenone on the intestinal morphology and microbial community of Chinese sea bass (Lateolabrax maculatus) under intermittent hypoxic stress. Fish Physiology and Biochemistry 46 (5):1873–82. doi: 10.1007/s10695-020-00838-0.
  • Eom, T., G. Ko, K. C. Kim, J.-S. Kim, and T. Unno. 2020. Dendropanax morbifera leaf extracts improved alcohol liver injury in association with changes in the gut microbiota of rats. Antioxidants 9 (10):911. doi: 10.3390/antiox9100911.
  • Falavigna, G., J. Alves de Araújo, M. M. Rogero, I. S. d O. Pires, R. G. Pedrosa, E. Martins, I. Alves de Castro, and J. Tirapegui. 2012. Effects of diets supplemented with branched-chain amino acids on the performance and fatigue mechanisms of rats submitted to prolonged physical exercise. Nutrients 4 (11):1767–80. doi: 10.3390/nu4111767.
  • Fan, S., H. Li, and R. Zhao. 2020. Effects of normoxic and hypoxic conditions on the immune response and gut microbiota of Bostrichthys sinensis. Aquaculture 525:735336. doi: 10.1016/j.aquaculture.2020.735336.
  • Fidelis, M., J. S. Santos, G. B. Escher, R. S. Rocha, A. G. Cruz, T. M. Cruz, M. B. Marques, J. B. Nunes, M. A. V. do Carmo, L. A. de Almeida, et al. 2021. Polyphenols of jabuticaba [Myrciaria jaboticaba (Vell.) O.Berg] seeds incorporated in a yogurt model exert antioxidant activity and modulate gut microbiota of 1,2-dimethylhydrazine-induced colon cancer in rats. Food Chemistry 334:127565. doi: 10.1016/j.foodchem.2020.127565.
  • Finaud, J., G. Lac, and E. Filaire. 2006. Oxidative stress: Relationship with exercise and training. Sports Medicine 36 (4):327–58. doi: 10.2165/00007256-200636040-00004.
  • Galland, L. 2014. The gut microbiome and the brain. Journal of Medicinal Food 17 (12):1261–72. doi: 10.1089/jmf.2014.7000.
  • Gibson, G. R., R. Hutkins, M. E. Sanders, S. L. Prescott, R. A. Reimer, S. J. Salminen, K. Scott, C. Stanton, K. S. Swanson, P. D. Cani, et al. 2017. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nature Reviews. Gastroenterology & Hepatology 14 (8):491–502. doi: 10.1038/nrgastro.2017.75.
  • Gilbert, C. 1995. Optimal physical performance in athletes: Key roles of dopamine in a specific neurotransmitter hormonal mechanism. Mechanisms of Ageing and Development 84 (2):83–102. doi: 10.1016/0047-6374(95)01635-X.
  • Gowd, V., T. Bao, and W. Chen. 2019. Antioxidant potential and phenolic profile of blackberry anthocyanin extract followed by human gut microbiota fermentation. Food Research International (Ottawa, Ont.) 120:523–33. doi: 10.1016/j.foodres.2018.11.001.
  • Gowd, V., L. Xie, C. Sun, and W. Chen. 2020. Phenolic profile of bayberry followed by simulated gastrointestinal digestion and gut microbiota fermentation and its antioxidant potential in HepG2 cells. Journal of Functional Foods 70:103987. doi: 10.1016/j.jff.2020.103987.
  • Han, N., Z. Pan, Z. Huang, Y. Chang, F. Hou, G. Liu, R. Yang, and Y. Bi. 2020. Effects of myeloid hif-1 beta deletion on the intestinal microbiota in mice under environmental hypoxia. Infection and Immunity 89 (1):e00474-20. doi: 10.1128/IAI.00474-20.
  • Han, N., Z. Pan, G. Liu, R. Yang, and J. B. Yu. 2021. Hypoxia: The "Invisible Pusher" of gut microbiota. Frontiers in Microbiology 12:690600. doi: 10.3389/fmicb.2021.690600.
  • Heyman-Linden, L., D. Kotowska, E. Sand, M. Bjursell, M. Plaza, C. Turner, C. Holm, F. Fak, and K. Berger. 2016. Lingonberries alter the gut microbiota and prevent low-grade inflammation in high-fat diet fed mice. Food & Nutrition Research 60 (1):29993. doi: 10.3402/fnr.v60.29993.
  • Hsu, Y.-J., W.-C. Huang, J.-S. Lin, Y.-M. Chen, S.-T. Ho, C.-C. Huang, and Y.-T. Tung. 2018. Kefir supplementation modifies gut microbiota composition, reduces physical fatigue, and improves exercise performance in mice. Nutrients 10 (7):862. doi: 10.3390/nu10070862.
  • Huang, C.-C., M.-C. Hsu, W.-C. Huang, H.-R. Yang, and C.-C. Hou. 2012. Triterpenoid-rich extract from Antrodia camphorata improves physical fatigue and exercise performance in mice. Evidence Based Complementary and Alternative Medicine 2012:364741. doi: 10.1155/2012/364741.
  • Huang, W.-C., M.-C. Lee, C.-C. Lee, K.-S. Ng, Y.-J. Hsu, T.-Y. Tsai, S.-L. Young, J.-S. Lin, and C.-C. Huang. 2019. Effect of Lactobacillus plantarum TWK10 on exercise physiological adaptation, performance, and body composition in healthy humans. Nutrients 11 (11):2836. doi: 10.3390/nu11112836.
  • Huang, W.-C., C.-C. Wei, C.-C. Huang, W.-L. Chen, and H.-Y. Huang. 2019. The beneficial effects of Lactobacillus plantarum PS128 on high-intensity, exercise-induced oxidative stress, inflammation, and performance in triathletes. Nutrients 11 (2):353. doi: 10.3390/nu11020353.
  • Isabel, M. I., T. Marta, S. A. Lidia, C. Fernando, A. Isaac, G. David, J. M. Montserrat, Q.-O. Maria, and F. Ramon. 2016. Normoxic recovery mimicking treatment of sleep apnea does not reverse intermittent hypoxia-induced bacterial dysbiosis and low-grade endotoxemia in mice. Sleep 39 (10):1891.
  • Jager, R., A. E. Mohr, and J. N. Pugh. 2020. Recent advances in clinical probiotic research for sport. Current Opinion in Clinical Nutrition & Metabolic Care 23 (6):428–36. doi: 10.1097/MCO.0000000000000686.
  • Jia, Z., X. Zhao, X. Liu, L. Zhao, Q. Jia, J. Shi, X. Xu, L. Hao, Z. Xu, Q. Zhong, et al. 2020. Impacts of the plateau environment on the gut microbiota and blood clinical indexes in Han and Tibetan individuals. Msystems 5 (1):e00660-19. doi: 10.1128/mSystems.00660-19.
  • Kelly, C. J., L. Zheng, E. L. Campbell, B. Saeedi, C. C. Scholz, A. J. Bayless, K. E. Wilson, L. E. Glover, D. J. Kominsky, A. Magnuson, et al. 2015. Crosstalk between microbiota-derived short-chain fatty acids and intestinal epithelial HIF augments tissue barrier function. Cell Host & Microbe 17 (5):662–71. doi: 10.1016/j.chom.2015.03.005.
  • Kim, J., J. H. Choi, G. Ko, H. Jo, T. Oh, B. Ahn, and T. Unno. 2020. Anti-inflammatory properties and gut microbiota modulation of Porphyra tenera extracts in dextran sodium sulfate-induced colitis in mice. Antioxidants 9 (10):988. doi: 10.3390/antiox9100988.
  • Kong, Q., S. Dong, J. Gao, and C. Jiang. 2016. In vitro fermentation of sulfated polysaccharides from E. prolifera and L. japonica by human fecal microbiota. International Journal of Biological Macromolecules 91:867–71. doi: 10.1016/j.ijbiomac.2016.06.036.
  • Koo, G. H., J. Woo, S. Kang, and K. O. Shin. 2014. Effects of supplementation with BCAA and L-glutamine on blood fatigue factors and cytokines in juvenile athletes submitted to maximal intensity rowing performance. Journal of Physical Therapy Science 26 (8):1241–6. doi: 10.1589/jpts.26.1241.
  • Kovatcheva-Datchary, P., A. Nilsson, R. Akrami, Y. S. Lee, F. De Vadder, T. Arora, A. Hallen, E. Martens, I. Björck, and F. Bäckhed. 2015. Dietary fiber-induced improvement in glucose metabolism is associated with increased abundance of Prevotella. Cell Metabolism 22 (6):971–82. doi: 10.1016/j.cmet.2015.10.001.
  • Lambertz, J., S. Weiskirchen, S. Landert, and R. Weiskirchen. 2017. Fructose: A dietary sugar in crosstalk with microbiota contributing to the development and progression of non-alcoholic liver disease. Frontiers in Immunology 8:1159. doi: 10.3389/fimmu.2017.01159.
  • Lebeer, S., J. Vanderleyden, and S. C. J. De Keersmaecker. 2010. Host interactions of probiotic bacterial surface molecules: Comparison with commensals and pathogens. Nature Reviews Microbiology 8 (3):171–84. doi: 10.1038/nrmicro2297.
  • Li, H., X. Chen, J. Liu, M. Chen, M. Huang, G. Huang, X. Chen, Q. Du, J. Su, and R. Lin. 2021. Ethanol extract of Centella asiatica alleviated dextran sulfate sodium-induced colitis: Restoration on mucosa barrier and gut microbiota homeostasis. Journal of Ethnopharmacology 267:113445. doi: 10.1016/j.jep.2020.113445.
  • Li, J., J. Han, J. Lv, S. Wang, L. Qu, and Y. Jiang. 2020. Saikosaponin A-induced gut microbiota changes attenuate severe acute ­pancreatitis through the activation of Keap1/Nrf2-ARE antioxidant signaling. Oxidative Medicine and Cellular Longevity 2020:9217219. doi: 10.1155/2020/9217219.
  • Li, Y., Y. Hao, B. Gao, P. Geng, H. Huang, L. Yu, U. Choe, J. Liu, J. Sun, P. Chen, et al. 2019. Chemical profile and in vitro gut microbiota modulatory, anti-inflammatory and free radical scavenging properties of chrysanthemum morifolium cv. Journal of Functional Foods 58:114–122. doi: 10.1016/j.jff.2019.04.053.
  • Li, Y., H. Pan, J.-X. Liu, T. Li, S. Liu, W. Shi, C. Sun, M. Fan, L. Xue, Y. Wang, et al. 2019. L-arabinose inhibits colitis by modulating gut microbiota in mice. Journal of Agricultural and Food Chemistry 67 (48):13299–13306. doi: 10.1021/acs.jafc.9b05829.
  • Liu, W., J. W. Crott, L. Lyu, A. C. Pfalzer, J. Li, S.-W. Choi, Y. Yang, J. B. Mason, and Z. Liu. 2016. Diet- and genetically-induced obesity produces alterations in the microbiome, inflammation and Wnt pathway in the intestine of Apc (+/1638N) mice: Comparisons and contrasts. Journal of Cancer 7 (13):1780–1790. doi: 10.7150/jca.15792.
  • Liu, Y., Y. Li, Y. Ke, C. Li, Z. Zhang, Y. Wu, B. Hu, A. Liu, Q. Luo, and W. Wu. 2021. In vitro saliva-gastrointestinal digestion and fecal fermentation of Oudemansiella radicata polysaccharides reveal its digestion profile and effect on the modulation of the gut microbiota. Carbohydrate Polymers 251:117041. doi: 10.1016/j.carbpol.2020.117041.
  • Liu, J., T. Li, H. Wu, H. Shi, J. Bai, W. Zhao, D. Jiang, and X. Jiang. 2019. Lactobacillus rhamnosus GG strain mitigated the development of obstructive sleep apnea-induced hypertension in a high salt diet via regulating TMAO level and CD4+ T cell induced-type I inflammation. Biomedicine & Pharmacotherapy 112:108580. doi: 10.1016/j.biopha.2019.01.041.
  • Liu, Z., Y. Wu, T. Liu, R. Li, and M. Xie. 2017. Serotonin regulation in a rat model of exerciseinduced chronic fatigue. Neuroscience 349:27–34. doi: 10.1016/j.neuroscience.2017.02.037.
  • Lucking, E. F., K. M. O’Connor, C. R. Strain, F. Fouhy, T. F. S. Bastiaanssen, D. P. Burns, A. V. Golubeva, C. Stanton, G. Clarke, J. F. Cryan, et al. 2018. Chronic intermittent hypoxia disrupts cardiorespiratory homeostasis and gut microbiota composition in adult male guinea-pigs. Ebiomedicine 38:191–205. doi: 10.1016/j.ebiom.2018.11.010.
  • Ma, Y., S. Ma, L. Chang, H. J. Wang, Q. Ga, L. Ma, Z. Z. Bai, Y. Y. Shen, and R. L. Ge. 2019. Gut microbiota adaptation to high altitude in indigenous animals. Biochemical and Biophysical Research Communications 516 (1):120–126. doi: 10.1016/j.bbrc.2019.05.085.
  • Madsen, K., A. Cornish, P. Soper, C. McKaigney, H. Jijon, C. Yachimec, J. Doyle, L. Jewell, and C. D. Simone. 2001. Probiotic bacteria enhance murine and human intestinal epithelial barrier function. Gastroenterology 121 (3):580–591. doi: 10.1053/gast.2001.27224.
  • Maes, M., I. Mihaylova, and J. C. Leunis. 2007. Increased serum IgA and IgM against LPS of enterobacteria in chronic fatigue syndrome (CFS): Indication for the involvement of gram-negative enterobacteria in the etiology of CFS and for the presence of an increased gut-intestinal permeability. Journal of Affective Disorders 99 (1-3):237–240. doi: 10.1016/j.jad.2006.08.021.
  • Makras, P., G. N. Koukoulis, G. Bourikas, G. Papatheodorou, K. Bedevis, P. Menounos, D. Pappas, and G. Kartalis. 2005. Effect of 4 weeks of basic military training on peripheral blood leucocytes and urinary excretion of catecholamines and cortisol. Journal of Sports Sciences 23 (8):825–834. doi: 10.1080/02640410400021815.
  • Maslowski, K. M., A. T. Vieira, A. Ng, J. Kranich, F. Sierro, D. Yu, H. C. Schilter, M. S. Rolph, F. Mackay, D. Artis, et al. 2009. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 461 (7268):1282–U1119. doi: 10.1038/nature08530.
  • Mason, S. A., D. Morrison, G. K. McConell, and G. D. Wadley. 2016. Muscle redox signalling pathways in exercise. Role of antioxidants. Free Radical Biology & Medicine 98:29–45. doi: 10.1016/j.freeradbiomed.2016.02.022.
  • Meeusen, R., and B. Roelands. 2018. Fatigue: Is it all neurochemistry? European Journal of Sport Science 18 (1):37–46. doi: 10.1080/17461391.2017.1296890.
  • Miao, F., C. Shan, S. A. H. Shah, R. W. Akhtar, X. Wang, and D. Ning. 2021. Effect of walnut (Juglans sigillata) oil on intestinal antioxidant, anti-inflammatory, immunity, and gut microbiota modulation in mice. Journal of Food Biochemistry 45 (1):e13567. doi: 10.1111/jfbc.13567.
  • Mohr, A. E., R. Jäger, K. C. Carpenter, C. M. Kerksick, M. Purpura, J. R. Townsend, N. P. West, K. Black, M. Gleeson, D. B. Pyne, et al. 2020. The athletic gut microbiota. Journal of the International Society of Sports Nutrition 17 (1):24. doi: 10.1186/s12970-020-00353-w.
  • Moreno-Indias, I., M. Torres, J. M. Montserrat, L. Sanchez-Alcoholado, F. Cardona, F. J. Tinahones, D. Gozal, V. A. Poroyko, D. Navajas, M. I. Queipo-Ortuno, et al. 2015. Intermittent hypoxia alters gut microbiota diversity in a mouse model of sleep apnoea. European Respiratory Journal 45 (4):1055–1065. doi: 10.1183/09031936.00184314.
  • Moreno-Indias, I., M. Torres, L. Sanchez-Alcoholado, F. Cardona, I. Almendros, D. Gozal, J. M. Montserrat, M. I. Queipo-Ortuño, R. Farré. 2016. Normoxic Recovery Mimicking Treatment of Sleep Apnea Does Not Reverse Intermittent Hypoxia-Induced Bacterial Dysbiosis and Low-Grade Endotoxemia in Mice. Sleep 39 (10):1891–7. doi: 10.5665/sleep.6176.
  • Nagy-Szakal, D., B. L. Williams, N. Mishra, X. Che, B. Lee, L. Bateman, N. G. Klimas, A. L. Komaroff, S. Levine, J. G. Montoya, et al. 2017. Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome. Microbiome 5 (1):44. doi: 10.1186/s40168-017-0261-y.
  • Nielsen, O. B., F. de Paoli, and K. Overgaard. 2001. Protective effects of lactic acid on force production in rat skeletal muscle. The Journal of Physiology 536 (1):161–6. doi: 10.1111/j.1469-7793.2001.t01-1-00161.x.
  • O’Connor, K. M., E. F. Lucking, T. F. S. Bastiaanssen, V. L. Peterson, F. Crispie, P. D. Cotter, G. Clarke, J. F. Cryan, and K. D. O’Halloran. 2020. Prebiotic administration modulates gut microbiota and faecal short-chain fatty acid concentrations but does not prevent chronic intermittent hypoxia-induced apnoea and hypertension in adult rats. Ebiomedicine 59:102968. doi: 10.1016/j.ebiom.2020.102968.
  • Ortenblad, N., H. Westerblad, and J. Nielsen. 2013. Muscle glycogen stores and fatigue. The Journal of Physiology 591 (18):4405–4413. doi: 10.1113/jphysiol.2013.251629.
  • Pasiakos, S. M., H. R. Lieberman, and T. M. McLellan. 2014. Effects of protein supplements on muscle damage, soreness and recovery of muscle function and physical performance: A systematic review. Sports Med 44 (5):655–670. doi: 10.1007/s40279-013-0137-7.
  • Peng, H., Q. Chen, and Y. Tan. 2009. Frequent ejaculation associated free radical and lactic acid accumulation cause noninfectious inflammation and muscle dysfunction: A potential mechanism for symptoms in chronic prostatitis/chronic pelvic pain syndrome. Medical Hypotheses 73 (3):372–373. doi: 10.1016/j.mehy.2009.03.044.
  • Peng, Y., Y. Yan, P. Wan, W. Dong, K. Huang, L. Ran, J. Mi, L. Lu, X. Zeng, and Y. Cao. 2020. Effects of long-term intake of anthocyanins from Lycium ruthenicum Murray on the organism health and gut microbiota in vivo. Food Research International (Ottawa, Ont.) 130:108952. doi: 10.1016/j.foodres.2019.108952.
  • Peng, M., X. Zhao, and D. Biswas. 2017. Polyphenols and tri-terpenoids from Olea europaea L. in alleviation of enteric pathogen infections through limiting bacterial virulence and attenuating inflammation. Journal of Functional Foods 36:132–143. doi: 10.1016/j.jff.2017.06.059.
  • Pieter, H., L. Debby, D. A. Ferdinando, and D. Silvio. 2017. Unmet needs in IBD: The case of fatigue. Clinical Reviews in Allergy & Immunology 55 (3):368–378. doi: 10.1007/s12016-017-8641-4.
  • Pugh, J. N., A. J. M. Wagenmakers, D. A. Doran, S. C. Fleming, B. A. Fielding, J. P. Morton, and G. L. Close. 2020. Probiotic supplementation increases carbohydrate metabolism in trained male cyclists: A randomized, double-blind, placebo-controlled crossover trial. American Journal of Physiology Endocrinology and Metabolism 318 (4):E504–E513. doi: 10.1152/ajpendo.00452.2019.
  • Quagliariello, A., M. D. Paola, S. De Fanti, G. A. Gnecchi-Ruscone, L. Martinez-Priego, D. Perez-Villaroya, M. G. Sherpa, P. T. Sherpa, G. Marinelli, and L. Natali. 2019. Gut microbiota composition in Himalayan and Andean populations and its relationship with diet, lifestyle and adaptation to the high-altitude environment. Journal of Anthropological Sciences 97:189–208. doi: 10.4436/jass.97007.
  • Ramos-Romero, S., G. Santocildes, D. Piñol-Piñol, C. Rosés, T. Pagés, M. Hereu, S. Amézqueta, J. R. Torrella, J. L. Torres, and G. Viscor. 2020. Implication of gut microbiota in the physiology of rats intermittently exposed to cold and hypobaric hypoxia. PLoS One 15 (11):e0240686. doi: 10.1371/journal.pone.0240686.
  • Reigstad, C. S., C. E. Salmonson, J. F. Rainey, J. H. Szurszewski, D. R. Linden, J. L. Sonnenburg, G. Farrugia, and P. C. Kashyap. 2015. Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells. The FASEB Journal 29 (4):1395–1403. doi: 10.1096/fj.14-259598.
  • Ribeiro, T. B., C. M. Costa, T. Bonifacio-Lopes, S. Silva, M. Veiga, A. R. Monforte, J. Nunes, A. A. Vicente, and M. Pintado. 2021. Prebiotic effects of olive pomace powders in the gut: In vitro evaluation of the inhibition of adhesion of pathogens, prebiotic and antioxidant effects. Food Hydrocolloids 112:106312. doi: 10.1016/j.foodhyd.2020.106312.
  • Rooj, A. K., Y. Kimura, and R. K. Buddington. 2010. Metabolites produced by probiotic Lactobacilli rapidly increase glucose uptake by Caco-2 cells. BMC Microbiology 10:16. doi: 10.1186/1471-2180-10-16.
  • Samanta, A., A. Patra, S. Mandal, S. Roy, K. Das, S. Kar, and D. K. Nandi. 2018. Hypoxia: A cause of acute renal failure and alteration of gastrointestinal microbial ecology. Saudi Journal of Kidney Diseases and Transplantation 29 (4):879–888. doi: 10.4103/1319-2442.239653.
  • Shao, X., C. Sun, X. Tang, X. Zhang, D. Han, S. Liang, R. Qu, X. Hui, Y. Shan, L. Hu, et al. 2020. Anti-inflammatory and intestinal microbiota modulation properties of Jinxiang garlic (Allium sativum L.) polysaccharides toward dextran sodium sulfate-induced colitis. Journal of Agricultural and Food Chemistry 68 (44):12295–12309. doi: 10.1021/acs.jafc.0c04773.
  • Sheedy, J. R., R. E. H. Wettenhall, D. Scanlon, P. R. Gooley, D. P. Lewis, N. McGregor, D. I. Stapleton, H. L. Butt, and K. L. De Meirleir. 2009. Increased D-lactic acid intestinal bacteria in patients with chronic fatigue syndrome. Vivo 23 (4):621–628. doi: 10.1089/hum.2008.163.
  • Shin, N. R., T. W. Whon, and J. W. Bae. 2015. Proteobacteria: Microbial signature of dysbiosis in gut microbiota. Trends in Biotechnology 33 (9):496–503. doi: 10.1016/j.tibtech.2015.06.011.
  • Sinisgalli, C., T. Vezza, P. Diez-Echave, A. Ostuni, I. Faraone, L. Hidalgo-Garcia, D. Russo, M. F. Armentano, J. Garrido-Mesa, M. E. Rodriguez-Cabezas, et al. 2021. The beneficial effects of red sun-dried Capsicum annuum L. cv Senise extract with antioxidant properties in experimental obesity are associated with modulation of the intestinal microbiota. Molecular Nutrition & Food Research 65 (3):2000812. doi: 10.1002/mnfr.202000812.
  • Suji, G., and S. Sivakami. 2008. Malondialdehyde, a lipid-derived aldehyde alters the reactivity of Cys34 and the esterase activity of serum albumin. Toxicology in Vitro : An International Journal Published in Association with BIBRA 22 (3):618–624. doi: 10.1016/j.tiv.2007.12.003.
  • Sun, Y., S. Chen, R. Wei, X. Xie, C. Wang, S. Fan, X. Zhang, J. Su, J. Liu, W. Jia, et al. 2018. Metabolome and gut microbiota variation with long-term intake of Panax ginseng extracts on rats. Food & Function 9 (6):3547–3556. doi: 10.1039/c8fo00025e.
  • Sun, J., Y. Gou, J. Liu, H. Chen, J. Kan, C. Qian, N. Zhang, F. Niu, and C. Jin. 2020. Anti-inflammatory activity of a water-soluble polysaccharide from the roots of purple sweet potato. RSC Advances 10 (65):39673–39686. doi: 10.1039/D0RA07551E.
  • Sun, Y., J. Zhang, A. Zhao, W. Li, Q. Feng, and R. Wang. 2020. Effects of intestinal flora on the pharmacokinetics and pharmacodynamics of aspirin in high-altitude hypoxia effects of intestinal flora on the pharmacokinetics and pharmacodynamics of aspirin in high-altitude hypoxia. PLoS One 15 (3):e0230197. doi: 10.1371/journal.pone.0230197.
  • Takahashi, K., H. Terashima, K. Kohno, and N. Ohkohchi. 2013. A stand-alone synbiotic treatment for the prevention of d-lactic acidosis in short bowel syndrome. International Surgery 98 (2):110–113. doi: 10.9738/cc169.
  • Thilakarathna, W. P. D. W., M. G. I. Langille, and H. P. V. Rupasinghe. 2018. Polyphenol-based prebiotics and synbiotics: Potential for cancer chemoprevention. Current Opinion in Food Science 20:51–57. doi: 10.1016/j.cofs.2018.02.011.
  • Trinity, J. D., R. M. Broxterman, and R. S. Richardson. 2016. Regulation of exercise blood flow: Role of free radicals. Free Radical Biology & Medicine 98:90–102. doi: 10.1016/j.freeradbiomed.2016.01.017.
  • Uribarri, J., M. S. Oh, and H. J. Carroll. 1998. D-lactic acidosis. A review of clinical presentation, biochemical features, and pathophysiologic mechanisms. Medicine 77 (2):73–82. doi: 10.1097/00005792-199803000-00001.
  • Valentini, F., M. Evangelisti, M. Arpinelli, G. D. Nardo, M. Borro, M. Simmaco, and M. P. Villa. 2020. Gut microbiota composition in children with obstructive sleep apnoea syndrome: A pilot study. Sleep Medicine 76:140–147. doi: 10.1016/j.sleep.2020.10.017.
  • Wan, X., X. Li, D. Liu, X. Gao, Y. Chen, Z. Chen, C. Fu, L. Lin, B. Liu, and C. Zhao. 2021. Physicochemical characterization and antioxidant effects of green microalga Chlorella pyrenoidosa polysaccharide by regulation of microRNAs and gut microbiota in Caenorhabditis elegans. International Journal of Biological Macromolecules 168:152–162. doi: 10.1016/j.ijbiomac.2020.12.010.
  • Westerterp, K. R., and B. Kayser. 2006. Body mass regulation at altitude. European Journal of Gastroenterology & Hepatology 18 (1):1–3. doi: 10.1097/00042737-200601000-00001.
  • Wu, C.-C., Y.-T. Tung, S.-Y. Chen, W.-T. Lee, H.-T. Lin, and G.-C. Yen. 2020. Anti-inflammatory, antioxidant, and microbiota-modulating effects of camellia oil from Camellia brevistyla on acetic acid-induced colitis in rats. Antioxidants 9 (1):58. doi: 10.3390/antiox9010058.
  • Xiang, L., Q. Wu, H. Osada, M. Yoshida, W. Pan, and J. Qi. 2020. Peanut skin extract ameliorates the symptoms of type 2 diabetes mellitus in mice by alleviating inflammation and maintaining gut microbiota homeostasis. Aging 12 (14):13991–14018. doi: 10.18632/aging.103521.
  • Xiao, M., L. Lin, H. Chen, X. Ge, Y. Huang, Z. Zheng, S. Li, Y. Pan, B. Liu, and F. Zeng. 2020. Anti-fatigue property of the oyster polypeptide fraction and its effect on gut microbiota in mice. Food & Function 11 (10):8659–8669. doi: 10.1039/d0fo01713b.
  • Xing, Y. Y., Y. Q. Xu, X. Jin, L. L. Shi, S. W. Guo, S. M. Yan, and B. L. Shi. 2020. Optimization extraction and characterization of Artemisia ordosica polysaccharide and its beneficial effects on antioxidant function and gut microbiota in rats. RSC Advances 10 (44):26151–26164. doi: 10.1039/D0RA05063F.
  • Xing, J., Y. Ying, C. Mao, Y. Liu, T. Wang, Q. Zhao, X. Zhang, F. Yan, and H. Zhang. 2018. Hypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiota. Nature Communications 9 (1):2020. doi: 10.1038/s41467-018-04453-9.
  • Xu, M., Y. Kitaura, T. Ishikawa, Y. Kadota, C. Terai, D. Shindo, T. Morioka, M. Ota, Y. Morishita, K. Ishihara, et al. 2017. Endurance performance and energy metabolism during exercise in mice with a muscle-specific defect in the control of branched-chain amino acid catabolism. PLoS One 12 (7):e0180989. doi: 10.1371/journal.pone.0180989.
  • Yang, J., L. B. Bindels, R. R. S. Munoz, I. Martinez, J. Walter, A. E. Ramer-Tait, and D. J. Rose. 2016. Disparate metabolic responses in mice fed a high-fat diet supplemented with maize-derived non-digestible feruloylated oligo and polysaccharides are linked to changes in the gut microbiota. PLoS One 11 (1):e0146144. doi: 10.1371/journal.pone.0146144.
  • Yano, J. M., K. Yu, G. P. Donaldson, G. G. Shastri, P. Ann, L. Ma, C. R. Nagler, R. F. Ismagilov, S. K. Mazmanian, and E. Y. Hsiao. 2015. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell 161 (2):264–276. doi: 10.1016/j.cell.2015.02.047.
  • Yan, F., and D. B. Polk. 2002. Probiotic bacterium prevents cytokine-induced apoptosis in intestinal epithelial cells. Journal of Biological Chemistry 277 (52):50959–50965. doi: 10.1074/jbc.M207050200.
  • Yan, T., N. Wang, B. Liu, B. Wu, F. Xiao, B. He, and Y. Jia. 2021. Schisandra chinensis ameliorates depressive-like behaviors by regulating microbiota-gut-brain axis via its anti-inflammation activity. Phytotherapy Research 35 (1):289–296. doi: 10.1002/ptr.6799.
  • Yan, Z., H. Wu, H. Yao, W. Pan, M. Su, T. Chen, W. Su, and Y. Wang. 2019. Rotundic acid protects against metabolic disturbance and improves gut microbiota in type 2 diabetes rats. Nutrients 12 (1):67. doi: 10.3390/nu12010067.
  • Yan, S., B. Yang, R. P. Ross, C. Stanton, H. Zhang, J. Zhao, and W. Chen. 2020. Bifidobacterium longum subsp. longum YS108R fermented milk alleviates DSS induced colitis via anti-inflammation, mucosal barrier maintenance and gut microbiota modulation. Journal of Functional Foods 73:104153. doi: 10.1016/j.jff.2020.104153.
  • Yu, Y., Y. Zhou, T. Cheng, X. Lu, K. Yu, Y. Zhou, J. Hong, and Y. Chen. 2016. Hypoxia enhances tenocyte differentiation of adipose-derived mesenchymal stem cells by inducing hypoxia-inducible factor-1α in a co-culture system. Cell Proliferation 49 (2):173–184. doi: 10.1111/cpr.12250.
  • Yuan, L., X. Li, S. He, C. Gao, C. Wang, and Y. Shao. 2018. Effects of natural flavonoid-isoorientin on growth performance and gut microbiota of mice. Journal of Agricultural and Food Chemistry 66 (37):9777–9784. doi: 10.1021/acs.jafc.8b03568.
  • Zhang, X., J. Chen, P. Xu, and X. Tian. 2018. Protective effects of astragaloside IV against hypoxic pulmonary hypertension. MedChemComm 9 (10):1715–1721. doi: 10.1039/c8md00341f.
  • Zhang, N., X. Mao, R. W. Li, E. Hou, Y. Wang, C. Xue, and Q. Tang. 2017. Neoagarotetraose protects mice against intense exercise-induced fatigue damage by modulating gut microbial composition and function. Molecular Nutrition & Food Research 61 (8):1600585. doi: 10.1002/mnfr.201600585.
  • Zhang, X., H. Wang, P. Yin, H. Fan, L. Sun, and Y. Liu. 2017. Flaxseed oil ameliorates alcoholic liver disease via anti-inflammation and modulating gut microbiota in mice. Lipids in Health and Disease 16 (1):44. doi: 10.1186/s12944-017-0431-8.
  • Zhang, Q., Y. Wu, J. Wang, G. Wu, W. Long, Z. Xue, L. Wang, X. Zhang, X. Pang, Y. Zhao, et al. 2016. Accelerated dysbiosis of gut microbiota during aggravation of DSS-induced colitis by a butyrate-producing bacterium. Scientific Reports 6:27572. doi: 10.1038/srep27572.
  • Zhang, Z., D. Xu, L. Wang, J. Hao, J. Wang, X. Zhou, W. Wang, Q. Qiu, X. Huang, J. Zhou, et al. 2016. Convergent evolution of rumen microbiomes in high-altitude mammals. Current Biology : CB 26 (14):1873–1879. doi: 10.1016/j.cub.2016.05.012.
  • Zhang, X., N. Zhang, J. Kan, R. Sun, S. Tang, Z. Wang, M. Chen, J. Liu, and C. Jin. 2020. Anti-inflammatory activity of alkali-soluble polysaccharides from Arctium lappa L. and its effect on gut microbiota of mice with inflammation. International Journal of Biological Macromolecules 154:773–787. doi: 10.1016/j.ijbiomac.2020.03.111.
  • Zhao, R., Y. Ji, X. Chen, A. Su, G. Ma, G. Chen, Q. Hu, and L. Zhao. 2020. Effects of a β-type glycosidic polysaccharide from Flammulina velutipes on anti-inflammation and gut microbiota modulation in colitis mice. Food & Function 11 (5):4259–4274. doi: 10.1039/c9fo03017d.
  • Zhong, L., N. Ma, H. Zheng, G. Ma, L. Zhao, and Q. Hu. 2019. Tuber indicum polysaccharide relieves fatigue by regulating gut microbiota in mice. Journal of Functional Foods 63:103580. doi: 10.1016/j.jff.2019.103580.
  • Zhou, L., M. Xie, F. Yang, and J. Liu. 2020. Antioxidant activity of high purity blueberry anthocyanins and the effects on human intestinal microbiota. LWT 117:108621. doi: 10.1016/j.lwt.2019.108621.

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