Structure and biological activities of glycoproteins and their metabolites in maintaining intestinal health

References

• Balan, P., K. S. Han, B. Lawley, and P. J. Moughan. 2013. Orally administered ovine serum immunoglobulins modulate the intestinal levels of Lactobacillus and enterobacteria in the growing rat. Journal of Animal Science 91 (8):3724–32. doi: 10.2527/jas.2012-6028.
   PubMed Web of Science ®Google Scholar
• Balan, P., K. S. Han, K. Rutherfurd-Markwick, H. Singh, and P. J. Moughan. 2011. Ovine serum immunoglobulin has immunomodulatory effects in growing rats gavaged with Salmonella enteritidis. The Journal of Nutrition 141 (5):950–6. doi: 10.3945/jn.110.131433.
   PubMed Web of Science ®Google Scholar
• Balan, P., K. Sik-Han, and P. J. Moughan. 2019. Impact of oral immunoglobulins on animal health-A review. Animal Science Journal = Nihon Chikusan Gakkaiho 90 (9):1099–110. doi: 10.1111/asj.13258.
   PubMed Web of Science ®Google Scholar
• Bertuccini, L., M. Costanzo, F. Iosi, A. Tinari, F. Terruzzi, L. Stronati, M. Aloi, S. Cucchiara, and F. Superti. 2014. Lactoferrin prevents invasion and inflammatory response following E. coli strain LF82 infection in experimental model of Crohn’s disease. Digestive and Liver Disease: Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 46 (6):496–504. doi: 10.1016/j.dld.2014.02.009.
   PubMedGoogle Scholar
• Bosi, P., L. Casini, A. Finamore, C. Cremokolini, G. Merialdi, P. Trevisi, F. Nobili, and E. Mengheri. 2004. Spray-dried plasma improves growth performance and reduces inflammatory status of weaned pigs challenged with enterotoxigenic Escherichia coli K88. Journal of Animal Science 82 (6):1764–72. doi: 10.1111/j.1439-0396.2004.00481.x.
   PubMed Web of Science ®Google Scholar
• Burger-van Paassen, N., A. Vincent, P. J. Puiman, M. van der Sluis, J. Bouma, G. Boehm, J. B. van Goudoever, I. Van Seuningen, and I. B. Renes. 2009. The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: Implications for epithelial protection. The Biochemical Journal 420 (2):211–9. doi: 10.1042/bj20082222.
   PubMed Web of Science ®Google Scholar
• Cals, M. M., P. Mailliart, G. Brignon, P. Anglade, and B. R. Dumas. 1991. Primary structure of bovine lactoperoxidase, a fourth member of a mammalian heme peroxidase family. European Journal of Biochemistry 198 (3):733–9. doi: 10.1111/j.1432-1033.1991.tb16073.x.
   PubMedGoogle Scholar
• Camara-Lemarroy, C. R., L. Metz, J. B. Meddings, K. A. Sharkey, and V. W. Yong. 2018. The intestinal barrier in multiple sclerosis: Implications for pathophysiology and therapeutics. Brain: A Journal of Neurology 141 (7):1900–16. doi: 10.1093/brain/awy131.
   PubMedGoogle Scholar
• Chen, J. N., C. Y. Ma, P. F. Tsai, Y. T. Wang, and J. S. B. Wu. 2010. In vitro antitumor and immunomodulatory effects of the protein PCP-3A from mushroom pleurotus citrinopileatus. Journal of Agricultural and Food Chemistry 58 (23):12117–22. doi: 10.1021/jf103576r.
   PubMed Web of Science ®Google Scholar
• Chen, Y. J., K. M. Guo, T. Nagy, and T. L. Guo. 2020. Chronic oral exposure to glycated whey proteins increases survival of aged male NOD mice with autoimmune prostatitis by regulating the gut microbiome and anti-inflammatory responses. Food & Function 11 (1):153–62. doi: 10.1039/c9fo01740b.
   PubMed Web of Science ®Google Scholar
• Cheng, X., X. Tang, Q. Wang, and X. Y. Mao. 2013. Antibacterial effect and hydrophobicity of yak kappa-casein hydrolysate and its fractions. International Dairy Journal 31 (2):111–6. doi: 10.1016/j.idairyj.2012.12.004.
   Web of Science ®Google Scholar
• Claustre, J., F. Toumi, A. Trompette, G. Jourdan, H. Guignard, J. A. Chayvialle, and P. Plaisancie. 2002. Effects of peptides derived from dietary proteins on mucus secretion in rat jejunum. American Journal of Physiology. Gastrointestinal and Liver Physiology 283 (3):G521–G528. doi: 10.1152/ajpgi.00535.2001.
   PubMed Web of Science ®Google Scholar
• Coeffier, M., R. Marion, P. Ducrotte, and P. Dechelotte. 2003. Modulating effect of glutamine on IL-1 beta-induced cytokine production by human gut. Clinical Nutrition 22 (4):407–13. doi: 10.1016/s0261-5614(03)00040-2.
   PubMed Web of Science ®Google Scholar
• Corzo-Martinez, M., O. Hernandez-Hernandez, M. Villamiel, R. A. Rastall, and F. J. Moreno. 2013. In vitro bifidogenic effect of Maillard-type milk protein-galactose conjugates on the human intestinal microbiota. International Dairy Journal 31 (2):127–31. doi: 10.1016/j.idairyj.2013.01.004.
   Web of Science ®Google Scholar
• Dai, W., Y. Li, Y. N. Lv, C. D. Wei, and H. Y. Zheng. 2014. The roles of a novel anti-inflammatory factor, milk fat globule-epidermal growth factor 8, in patients with coronary atherosclerotic heart disease. Atherosclerosis 233 (2):661–5. doi: 10.1016/j.atherosclerosis.2014.01.013.
   PubMed Web of Science ®Google Scholar
• Danese, S., and A. Gasbarrini. 2005. Chemokines in inflammatory bowel disease. Journal of Clinical Pathology 58 (10):1025–7. doi: 10.1136/jcp.2005.030916.
   PubMed Web of Science ®Google Scholar
• Davis, C. D., and J. A. Milner. 2009. Gastrointestinal microflora, food components and colon cancer prevention. The Journal of Nutritional Biochemistry 20 (10):743–52. doi: 10.1016/j.jnutbio.2009.06.001.
   PubMed Web of Science ®Google Scholar
• de Kruif, C. G., J. Pedersen, T. Huppertz, and S. G. Anema. 2013. Coacervates of lactotransferrin and β- or κ-casein: structure determined using SAXS. Langmuir: The ACS Journal of Surfaces and Colloids 29 (33):10483–90. doi: 10.1021/la402236f.
   PubMed Web of Science ®Google Scholar
• Dominika, Ś., N. Arjan, R. P. Karyn, and K. Henryk. 2011. The study on the impact of glycated pea proteins on human intestinal bacteria. International Journal of Food Microbiology 145 (1):267–72. doi: 10.1016/j.ijfoodmicro.2011.01.002.
   PubMed Web of Science ®Google Scholar
• Etienne-Mesmin, L., B. Chassaing, M. Desvaux, K. De Paepe, R. Gresse, T. Sauvaitre, E. Forano, T. V. de Wiele, S. Schüller, N. Juge, et al. 2019. Experimental models to study intestinal microbes-mucus interactions in health and disease. FEMS Microbiology Reviews 43 (5):457–89. doi: 10.1093/femsre/fuz013.
   PubMed Web of Science ®Google Scholar
• Fan, P., L. Li, A. Rezaei, S. Eslamfam, D. Che, and X. Ma. 2015. Metabolites of dietary protein and peptides by intestinal microbes and their impacts on gut. Current Protein & Peptide Science 16 (7):646–54. doi: 10.2174/1389203716666150630133657.
   PubMed Web of Science ®Google Scholar
• Farnaud, S., and R. W. Evans. 2003. Lactoferrin - a multifunctional protein with antimicrobial properties. Molecular Immunology 40 (7):395–405. doi: 10.1016/S0161-5890(03)00152-4.
   PubMed Web of Science ®Google Scholar
• Fu, C., H. Tian, T. Cai, Y. Liu, and Q. Li. 2007. Some properties of an acidic protein-bound polysaccharide from the fruit of pumpkin. Food Chemistry 100 (3):944–7. doi: 10.1016/j.foodchem.2005.10.049.
   Web of Science ®Google Scholar
• Giacaman, R. A., P. Jobet-Vila, and C. Munoz-Sandoval. 2019. Anticaries activity of egg ovalbumin in an experimental caries biofilm model on enamel and dentin. Clinical Oral Investigations 23 (9):3509–16. doi: 10.1007/s00784-018-2769-3.
   PubMed Web of Science ®Google Scholar
• Go, H., H. J. Hwang, and T. J. Nam. 2009. Glycoprotein extraction from Laminaria japonica promotes IEC-6 cell proliferation. International Journal of Molecular Medicine 24 (6):819–24. doi: 10.3892/ijmm_00000298.
   PubMed Web of Science ®Google Scholar
• Gong, H., Q. Yuan, J. Pang, T. Li, J. Li, B. Zhan, R. Chang, and X. Mao. 2020. Dietary milk fat globule membrane restores decreased intestinal mucosal barrier development and alterations of intestinal flora in infant-formula-fed rat pups. Molecular Nutrition & Food Research 64 (21):12. doi: 10.1002/mnfr.20:2000232.
   Web of Science ®Google Scholar
• Gustavo Hermes, R., F. Molist, J. Francisco Pérez, A. Gómez de Segura, M. Ywazaki, R. Davin, M. Nofrarías, T. K. Korhonen, R. Virkola, and S. M. Martín-Orúe. 2013. Casein glycomacropeptide in the diet may reduce Escherichia coli attachment to the intestinal mucosa and increase the intestinal lactobacilli of early weaned piglets after an enterotoxigenic E. coli K88 challenge. The British Journal of Nutrition 109 (6):1001–12. doi: 10.1017/s0007114512002978.
   PubMed Web of Science ®Google Scholar
• Han, K., W. Jin, Z. Mao, S. Dong, Q. Zhang, Y. Yang, B. Chen, H. Wu, and M. Zeng. 2018. Microbiome and butyrate production are altered in the gut of rats fed a glycated fish protein diet. Journal of Functional Foods 47:423–33. doi: 10.1016/j.jff.2018.06.007.
   Web of Science ®Google Scholar
• Han, K., Y. Yao, S. Dong, S. Jin, H. Xiao, H. Wu, and M. Zeng. 2017. Chemical characterization of the glycated myofibrillar proteins from grass carp (Ctenopharyngodon idella) and their impacts on the human gut microbiota in vitro fermentation. Food & Function 8 (3):1184–94. doi: 10.1039/C6FO01632D.
   PubMed Web of Science ®Google Scholar
• Hering, N. A., J. Luettig, S. M. Krug, S. Wiegand, G. Gross, E. A. van Tol, J. D. Schulzke, and R. Rosenthal. 2017. Lactoferrin protects against intestinal inflammation and bacteria-induced barrier dysfunction in vitro. Annals of the New York Academy of Sciences 1405 (1):177–88. doi: 10.1111/nyas.13405.
   PubMed Web of Science ®Google Scholar
• Huntington, J. A., and P. E. Stein. 2001. Structure and properties of ovalbumin. Journal of Chromatography. B, Biomedical Sciences and Applications 756 (1-2):189–98. doi: 10.1016/S0378-4347(01)00108-6.
   PubMedGoogle Scholar
• Iglesias-Figueroa, B. F., E. A. Espinoza-Sanchez, T. S. Siqueiros-Cendon, and Q. Rascon-Cruz. 2019. Lactoferrin as a nutraceutical protein from milk, an overview. International Dairy Journal 89:37–41. doi: 10.1016/j.idairyj.2018.09.004.
   Web of Science ®Google Scholar
• Jin, W., K. Han, S. Dong, Y. Yang, Z. Mao, M. Su, and M. Zeng. 2018. Modifications in gut microbiota and fermentation metabolites in the hindgut of rats after the consumption of galactooligosaccharide glycated with a fish peptide. Food & Function 9 (5):2853–64. doi: 10.1039/C7FO02002C.
   PubMed Web of Science ®Google Scholar
• Juliano, R. L., and V. Ling. 1976. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochimica et Biophysica Acta 455 (1):152–62. doi: 10.1016/0005-2736(76)90160-7.
   PubMed Web of Science ®Google Scholar
• Jung, H. C., L. Eckmann, S. K. Yang, A. Panja, J. Fierer, E. Morzycka-Wroblewska, and M. F. Kagnoff. 1995. A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion. The Journal of Clinical Investigation 95 (1):55–65. doi: 10.1172/jci117676.
   PubMed Web of Science ®Google Scholar
• Kau, A. L., P. P. Ahern, N. W. Griffin, A. L. Goodman, and J. I. Gordon. 2011. Human nutrition, the gut microbiome and the immune system. Nature 474 (7351):327–36. doi: 10.1038/nature10213.
   PubMed Web of Science ®Google Scholar
• Kawasaki, Y., H. Isoda, M. Tanimoto, S. Dosako, T. Idota, and K. Ahiko. 1992. Inhibition by lactoferrin and kappa-casein glycomacropeptide of binding of Cholera toxin to its receptor . Bioscience, Biotechnology, and Biochemistry 56 (2):195–8. doi: 10.1271/bbb.56.195.
   PubMed Web of Science ®Google Scholar
• Kho, Z. Y., and S. K. Lal. 2018. The human gut microbiome - A potential controller of wellness and disease. Frontiers in Microbiology 9:1835. doi: 10.3389/fmicb.2018.01835.
   PubMed Web of Science ®Google Scholar
• Kim, J. Y., Y. M. Lee, J. P. Park, K. T. Lim, and S. J. Lee. 2020. Phytoglycoprotein isolated from Dioscorea batatas Decne promotes intestinal epithelial wound healing. Chinese Journal of Natural Medicines 18 (10):738–48. doi: 10.1016/S1875-5364(20)60014-0.
   PubMed Web of Science ®Google Scholar
• Kim, K. A., Y. O. Son, S. S. Kim, Y. S. Jang, Y. H. Baek, C. C. Kim, J. H. Lee, and J. C. Lee. 2018. Glycoproteins isolated from Atractylodes macrocephala Koidz improve protective immune response induction in a mouse model. Food Science and Biotechnology 27 (6):1823–31. doi: 10.1007/s10068-018-0430-1.
   PubMed Web of Science ®Google Scholar
• Kim, Y. S., J. S. Kim, H. C. Jung, and I. S. Song. 2004. The effects of thalidomide on the stimulation of NF-kappa B activity and TNF-alpha production by lipopolysaccharide in a human colonic epithelial cell line. Molecules and Cells 17 (2):210–6. doi: 10.1016/j.jmb.2004.02.047.
   PubMed Web of Science ®Google Scholar
• Koh, A., F. De Vadder, P. Kovatcheva-Datchary, and F. Backhed. 2016. From dietary fiber to host physiology: Short-chain fatty acids as key bacterial metabolites. Cell 165 (6):1332–45. doi: 10.1016/j.cell.2016.05.041.
   PubMed Web of Science ®Google Scholar
• Krajmalnik-Brown, R., Z. E. Ilhan, D. W. Kang, and J. K. DiBaise. 2012. Effects of gut microbes on nutrient absorption and energy regulation. Nutrition in Clinical Practice: Official Publication of the American Society for Parenteral and Enteral Nutrition 27 (2):201–14. doi: 10.1177/0884533611436116.
   PubMed Web of Science ®Google Scholar
• Lang, T., G. C. Hansson, and T. Samuelsson. 2006. An inventory of mucin genes in the chicken genome shows that the mucin domain of Muc13 is encoded by multiple exons and that ovomucin is part of a locus of related gel-forming mucins. BMC Genomics 7:197. doi: 10.1186/1471-2164-7-197.
   PubMed Web of Science ®Google Scholar
• Li, Q. H., C. L. Fu, Y. K. Rui, G. H. Hu, and T. Y. Cai. 2005. Effects of protein-bound polysaccharide isolated from pumpkin on insulin in diabetic rats. Plant Foods for Human Nutrition 60 (1):13–6. doi: 10.1007/s11130-005-2536-x.
   PubMed Web of Science ®Google Scholar
• Liang, Z., X. Chen, L. Li, B. Li, and Z. Yang. 2020. The fate of dietary advanced glycation end products in the body: From oral intake to excretion. Critical Reviews in Food Science and Nutrition 60 (20):3475–91. doi: 10.1080/10408398.2019.1693958.
   PubMed Web of Science ®Google Scholar
• Liu, B., Z. T. Yu, C. Chen, D. E. Kling, and D. S. Newburg. 2012. Human milk mucin 1 and mucin 4 inhibit Salmonella enterica Serovar Typhimurium invasion of human intestinal epithelial cells in vitro. The Journal of Nutrition 142 (8):1504–9. doi: 10.3945/jn.111.155614.
   PubMed Web of Science ®Google Scholar
• Liu, L., A. R. Prudden, G. P. Bosman, and G. J. Boons. 2017. Improved isolation and characterization procedure of sialylglycopeptide from egg yolk powder. Carbohydrate Research 452:122–8. doi: 10.1016/j.carres.2017.10.001.
   PubMed Web of Science ®Google Scholar
• Liu, X., J. Wang, L. Liu, L. Cheng, Q. Huang, D. Wu, L. Peng, X. Shi, S. Li, and F. Geng. 2021. Quantitative N-glycoproteomic analyses provide insights into the effects of thermal processes on egg white functional properties. Food Chemistry 342:128252. doi: 10.1016/j.foodchem.2020.
   PubMed Web of Science ®Google Scholar
• Mack, D. R., S. Ahrne, L. Hyde, S. Wei, and M. A. Hollingsworth. 2003. Extracellular MUC3 mucin secretion follows adherence of Lactobacillus strains to intestinal epithelial cells in vitro. Gut 52 (6):827–33. doi: 10.1136/gut.52.6.827.
   PubMed Web of Science ®Google Scholar
• Mantis, N. J., N. Rol, and B. Corthesy. 2011. Secretory IgA’s complex roles in immunity and mucosal homeostasis in the gut. Mucosal Immunology 4 (6):603–11. doi: 10.1038/mi.2011.41.
   PubMed Web of Science ®Google Scholar
• Marchesi, J. R., D. H. Adams, F. Fava, G. D. A. Hermes, G. M. Hirschfield, G. Hold, M. N. Quraishi, J. Kinross, H. Smidt, K. M. Tuohy, et al. 2016. The gut microbiota and host health: A new clinical frontier. Gut 65 (2):330–9. doi: 10.1136/gutjnl-2015-309990.
   PubMed Web of Science ®Google Scholar
• Martens, E. C., M. Neumann, and M. S. Desai. 2018. Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier. Nature Reviews. Microbiology 16 (8):457–70. doi: 10.1038/s41579-018-0036-x.
   PubMed Web of Science ®Google Scholar
• Martinez-Duncker, I., R. Salinas-Marin, and C. Martinez-Duncker. 2011. Towards in vivo imaging of cancer sialylation. International Journal of Molecular Imaging 2011:283497. doi: 10.1155/2011/283497.
   PubMedGoogle Scholar
• Miceli, J. F., C. I. Torres, and R. Krajmalnik-Brown. 2016. Shifting the balance of fermentation products between hydrogen and volatile fatty acids: Microbial community structure and function. FEMS Microbiology Ecology 92 (12):fiw195–8. doi: 10.1093/femsec/fiw195.
   PubMed Web of Science ®Google Scholar
• Mitsuhashi, T., K. Ono, M. Fukuda, and Y. Hasegawa. 2013. Free radical scavenging ability and structure of a 90-kDa protein from the scallop shell. Fisheries Science 79 (3):495–502. doi: 10.1007/s12562-013-0616-7.
   Web of Science ®Google Scholar
• Neuberger, A. 1938. Carbohydrates in protein: The carbohydrate component of crystalline egg albumin. The Biochemical Journal 32 (9):1435–51. doi: 10.1042/bj0321435.
   PubMedGoogle Scholar
• Nie, S., M. Xie, P. Zhou, and S. Cao. 2007. In vitro antioxidative and anticancer activities of tea glycoprotein in green tea. European Food Research and Technology 224 (4):437–42. doi: 10.1007/s00217-006-0324-y.
   Web of Science ®Google Scholar
• Nie, S., M. Xie, Z. Fu, Y. Wan, and A. Yan. 2008. Study on the purification and chemical compositions of tea glycoprotein. Carbohydrate Polymers 71 (4):626–33. doi: 10.1016/j.carbpol.2007.07.005.
   Web of Science ®Google Scholar
• Nishikaze, T. 2019. Sialic acid derivatization for glycan analysis by mass spectrometry. Proceedings of the Japan Academy. Series B, Physical and Biological Sciences 95 (9):523–37. doi: 10.2183/pjab.95.036.
   PubMed Web of Science ®Google Scholar
• Niu, X., Z. He, W. Li, X. Wang, W. Zhi, F. Liu, and L. Qi. 2017. Immunomodulatory activity of the glycoprotein isolated from the Chinese Yam (Dioscorea opposita Thunb). Phytotherapy Research: PTR 31 (10):1557–63. doi: 10.1002/ptr.5896.
   PubMed Web of Science ®Google Scholar
• Nyangale, E. P., D. S. Mottram, and G. R. Gibson. 2012. Gut microbial activity, implications for health and disease: The potential role of metabolite analysis. Journal of Proteome Research 11 (12):5573–85. doi: 10.1021/pr300637d.
   PubMed Web of Science ®Google Scholar
• Oliphant, K., and E. Allen-Vercoe. 2019. Macronutrient metabolism by the human gut microbiome: Major fermentation by-products and their impact on host health. Microbiome 7 (1):91. doi: 10.1186/s40168-019-0704-8.
   PubMed Web of Science ®Google Scholar
• O’Riordan, N., J. O’Callaghan, L. F. Butto, M. Kilcoyne, L. Joshi, and R. M. Hickey. 2018. Bovine glycomacropeptide promotes the growth of Bifidobacterium longum ssp. infantis and modulates its gene expression. Journal of Dairy Science 101 (8):6730–41. doi: 10.3168/jds.2018-14499.
   PubMed Web of Science ®Google Scholar
• Patterson, E., P. M. Ryan, J. F. Cryan, T. G. Dinan, R. P. Ross, G. F. Fitzgerald, and C. Stanton. 2016. Gut microbiota, obesity and diabetes. Postgraduate Medical Journal 92 (1087):286–300. doi: 10.1136/postgradmedj-2015-133285.
   PubMed Web of Science ®Google Scholar
• Perez-Bosque, A., L. Miro, M. Maijo, J. Polo, J. Campbell, L. Russell, J. Crenshaw, E. Weaver, and M. Moreto. 2015. Dietary intervention with serum-derived bovine immunoglobulins protects barrier function in a mouse model of colitis. American Journal of Physiology-Gastrointestinal and Liver Physiology 308 (12):G1012–G1018. doi: 10.1152/ajpgi.00378.2014.
   PubMed Web of Science ®Google Scholar
• Phalipon, A., A. Cardona, J. P. Kraehenbuhl, L. Edelman, P. J. Sansonetti, and B. Corthesy. 2002. Secretory component: A new role in secretory IgA-mediated immune exclusion in vivo. Immunity 17 (1):107–15. doi: 10.1016/S1074-7613(02)00341-2.
   PubMed Web of Science ®Google Scholar
• Pham Thi Thu, H., C. H. Lee, M. H. Li, M. Y. Lee, J. K. Kim, S. M. Lee, J. H. Seon, D. C. Lee, and Y. J. Jeon. 2011. Characterization and immunopotentiating effects of the glycoprotein isolated from Dioscorea Batatas. The Korean Journal of Physiology & Pharmacology 15 (2):101–6. doi: 10.4196/kjpp.2011.15.2.101.
   PubMed Web of Science ®Google Scholar
• Pieper, R., C. Boudry, J. Bindelle, W. Vahjen, and J. Zentek. 2014. Interaction between dietary protein content and the source of carbohydrates along the gastrointestinal tract of weaned piglets. Archives of Animal Nutrition 68 (4):263–80. doi: 10.1080/1745039x.2014.932962.
   PubMed Web of Science ®Google Scholar
• Portune, K. J., M. Beaumont, A.-M. Davila, D. Tome, F. Blachier, and Y. Sanz. 2016. Gut microbiota role in dietary protein metabolism and health-related outcomes: The two sides of the coin. Trends in Food Science & Technology 57:213–32. doi: 10.1016/j.tifs.2016.08.011.
   Web of Science ®Google Scholar
• Pruss, K. M., A. Marcobal, A. M. Southwick, D. Dahan, S. A. Smits, J. A. Ferreyra, S. K. Higginbottom, E. D. Sonnenburg, P. C. Kashyap, B. Choudhury, et al. 2021. Mucin-derived O-glycans supplemented to diet mitigate diverse microbiota perturbations. The ISME Journal 15 (2):577–91. doi: 10.1038/s41396-020-00798-6.
   PubMed Web of Science ®Google Scholar
• Qin, L., W. Ji, J. Wang, B. Li, J. Hu, and X. Wu. 2019. Effects of dietary supplementation with yeast glycoprotein on growth performance, intestinal mucosal morphology, immune response and colonic microbiota in weaned piglets. Food & Function 10 (5):2359–71. doi: 10.1039/C8FO02327A.
   PubMed Web of Science ®Google Scholar
• Rafiquzzaman, S. M., E. Y. Kim, Y. R. Kim, T. J. Nam, and I. S. Kong. 2013. Antioxidant activity of glycoprotein purified from Undaria pinnatifida measured by an in vitro digestion model. International Journal of Biological Macromolecules 62:265–72. doi: 10.1016/j.ijbiomac.2013.09.009.
   PubMed Web of Science ®Google Scholar
• Ren, L. L., J. Ye, B. Zhao, J. B. Sun, P. Cao, and Y. Yang. 2021. The role of intestinal microbiota in colorectal cancer. Frontiers in Pharmacology 12:674807. doi: 10.3389/fphar.2021.674807.
   PubMed Web of Science ®Google Scholar
• Rey, F. E., M. D. Gonzalez, J. Cheng, M. Wu, P. P. Ahern, and J. I. Gordon. 2013. Metabolic niche of a prominent sulfate-reducing human gut bacterium. Proceedings of the National Academy of Sciences of the United States of America 110 (33):13582–7. doi: 10.1073/pnas.1312524110.
   PubMed Web of Science ®Google Scholar
• Rinninella, E., M. Cintoni, P. Raoul, L. R. Lopetuso, F. Scaldaferri, G. Pulcini, G. A. D. Miggiano, A. Gasbarrini, and M. C. Mele. 2019. Food components and dietary habits: Keys for a healthy gut microbiota composition. Nutrients 11 (10):2393. doi: 10.3390/nu11102393.
   PubMed Web of Science ®Google Scholar
• Rist, V. T. S., E. Weiss, N. Sauer, R. Mosenthin, and M. Eklund. 2014. Effect of dietary protein supply originating from soybean meal or casein on the intestinal microbiota of piglets. Anaerobe 25:72–9. doi: 10.1016/j.anaerobe.2013.10.003.
   PubMed Web of Science ®Google Scholar
• Salvo-Romero, E., C. Alonso-Cotoner, C. Pardo-Camacho, M. Casado-Bedmar, and M. Vicario. 2015. The intestinal barrier function and its involvement in digestive disease. Revista Espanola de Enfermedades Digestivas 107 (11):686–96. doi: 10.17235/reed.2015.3846/2015.
   PubMed Web of Science ®Google Scholar
• Sauvaitre, T., L. Etienne-Mesmin, A. Sivignon, P. Mosoni, C. M. Courtin, T. Van de Wiele, and S. Blanquet-Diot. 2021. Tripartite relationship between gut microbiota, intestinal mucus and dietary fibers: Towards preventive strategies against enteric infections. FEMS Microbiology Reviews 45 (2). doi: 10.1093/femsre/fuaa052: fuaa052.
   PubMed Web of Science ®Google Scholar
• Schauer, R. 2004. Sialic acids: Fascinating sugars in higher animals and man. Zoology (Jena, Germany) 107 (1):49–64. doi: 10.1016/j.zool.2003.10.002.
   PubMed Web of Science ®Google Scholar
• Schjoldager, K. T., Y. Narimatsu, H. J. Joshi, and H. Clausen. 2020. Global view of human protein glycosylation pathways and functions. Nature Reviews. Molecular Cell Biology 21 (12):729–49. doi: 10.1038/s41580-020-00294-x.
   PubMed Web of Science ®Google Scholar
• Schroeder, B. O. 2019. Fight them or feed them: How the intestinal mucus layer manages the gut microbiota. Gastroenterology Report 7 (1):3–12. doi: 10.1093/gastro/goy052.
   PubMed Web of Science ®Google Scholar
• Seko, A., M. Koketsu, M. Nishizono, Y. Enoki, H. R. Ibrahim, L. R. Juneja, M. Kim, and T. Yamamoto. 1997. Occurrence of a sialylglycopeptide and free sialylglycans in hen’s egg yolk. Biochimica et Biophysica Acta (Bba) - General Subjects 1335 (1–2):23–32. doi: 10.1016/S0304-4165(96)00118-3.
   PubMed Web of Science ®Google Scholar
• Severin, S., and W. S. Xia. 2005. Milk biologically active components as nutraceuticals: Review. Critical Reviews in Food Science and Nutrition 45 (7–8):645–56. doi: 10.1080/10408690490911756.
   PubMed Web of Science ®Google Scholar
• Shen, Z., Z. Huang, J. Xiao, and J. Cao. 2015. Purification, structural characterization and immunomodulatory activity of natto polysaccharide-protein complexes. Food Science 36 (13):215–22. doi: 10.7506/spkx1002-6630-201513040.
   Google Scholar
• Shi, J., and X. H. Zhao. 2019a. Chemical features of the oligochitosan-glycated caseinate digest and its enhanced protection on barrier function of the acrylamide-injured IEC-6 cells. Food Chemistry 290:246–54. doi: 10.1016/j.foodchem.2019.04.004.
   PubMed Web of Science ®Google Scholar
• Shi, J., and X. H. Zhao. 2019b. Influence of the Maillard-type caseinate glycation with lactose on the intestinal barrier activity of the caseinate digest in IEC-6 cells. Food & Function 10 (4):2010–21. doi: 10.1039/c8fo02607f.
   PubMed Web of Science ®Google Scholar
• Shimotoyodome, A., S. Meguro, T. Hase, I. Tokimitsu, and T. Sakata. 2000. Short chain fatty acids but not lactate or succinate stimulate mucus release in the rat colon. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 125 (4):525–31. doi: 10.1016/S1095-6433(00)00183-5.
   PubMed Web of Science ®Google Scholar
• Shylaja, M., and H. S. Seshadri. 1989. Glycoproteins: An overview. Biochemical Education 17 (4):170–8. doi: 10.1016/0307-4412(89)90136-2.
   Google Scholar
• Son, D. O., H. Satsu, and M. Shimizu. 2005. Histidine inhibits oxidative stress- and TNF-alpha-induced interleukin-8 secretion in intestinal epithelial cells. FEBS Letters 579 (21):4671–7. doi: 10.1016/j.febslet.2005.07.038.
   PubMed Web of Science ®Google Scholar
• Stadnyk, A. W. 2002. Intestinal epithelial cells as a source of inflammatory cytokines and chemokines. Canadian Journal of Gastroenterology 16 (4):241–6. doi: 10.1155/2002/941087.
   PubMed Web of Science ®Google Scholar
• Sugita-Konishi, Y., S. Sakanaka, K. Sasaki, L. P. Juneja, T. Noda, and F. Amano. 2002. Inhibition of bacterial adhesion and salmonella infection in BALB/c mice by sialyloligosaccharides and their derivatives from chicken egg yolk. Journal of Agricultural and Food Chemistry 50 (12):3607–13. doi: 10.1021/jf0116451.
   PubMed Web of Science ®Google Scholar
• Sun, X., M. Gänzle, C. J. Field, and J. Wu. 2016. Effect of proteolysis on the sialic acid content and bifidogenic activity of ovomucin hydrolysates. Food Chemistry 212:78–86. doi: 10.1016/j.foodchem.2016.05.153.
   PubMed Web of Science ®Google Scholar
• Swiatecka, D., H. Kostyra, and A. Swiatecki. 2010. Impact of glycated pea proteins on the activity of free-swimming and immobilised bacteria. Journal of the Science of Food and Agriculture 90 (11):1837–45. doi: 10.1002/jsfa.4022.
   PubMed Web of Science ®Google Scholar
• Tabasum, S., A. Noreen, A. Kanwal, M. Zuber, M. N. Anjum, and K. M. Zia. 2017. Glycoproteins functionalized natural and synthetic polymers for prospective biomedical applications: A review. International Journal of Biological Macromolecules 98:748–76. doi: 10.1016/j.ijbiomac.2017.01.078.
   PubMed Web of Science ®Google Scholar
• Takada, H., T. Katoh, and T. Katayama. 2020. Sialylated O -Glycans from hen egg white ovomucin are decomposed by mucin-degrading gut microbes. Journal of Applied Glycoscience 67 (2):31–9. doi: 10.5458/jag.jag.JAG-2019_0020.
   PubMed Web of Science ®Google Scholar
• Tangerman, A. 2009. Measurement and biological significance of the volatile sulfur compounds hydrogen sulfide, methanethiol and dimethyl sulfide in various biological matrices. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 877 (28):3366–77. doi: 10.1016/j.jchromb.2009.05.026.
   PubMed Web of Science ®Google Scholar
• Thum, C., W. Young, C. A. Montoya, N. C. Roy, and W. C. McNabb. 2020. In vitro fermentation of digested milk fat globule membrane from ruminant milk modulates piglet ileal and caecal microbiota. Frontiers in Nutrition 7:91. doi: 10.3389/fnut.2020.00091.
   PubMed Web of Science ®Google Scholar
• Touch, V., S. Hayakawa, S. Yamada, and S. Kaneko. 2004. Effects of a lactoperoxidase-thiocyanate-hydrogen peroxide system on Salmonella enteritidis in animal or vegetable foods. International Journal of Food Microbiology 93 (2):175–83. doi: 10.1016/j.ijfoodmicro.2003.11.004.
   PubMed Web of Science ®Google Scholar
• Tu, A., X. C. Wang, H. Chen, X. Jia, T. Wang, Y. Yi, B. Liu, W. Xin, X. Lu, and Y. Shan. 2021. Ovomucin ameliorates intestinal barrier and intestinal bacteria to attenuate DSS-Induced colitis in mice. Journal of Agricultural and Food Chemistry 69 (21):5887–96. doi: 10.1016/j.ijbiomac.2020.06.148.
   PubMed Web of Science ®Google Scholar
• Tu, A., X. Zhao, Y. Shan, and X. Lu. 2020. Potential role of ovomucin and its peptides in modulation of intestinal health: A review. International Journal of Biological Macromolecules 162:385–93. doi: 10.1016/j.ijbiomac.2020.06.148.
   PubMed Web of Science ®Google Scholar
• Unkeless, J. C., E. Scigliano, and V. H. Freedman. 1988. Structure and function of human and murine receptors for IgG. Annual Review of Immunology 6:251–81. doi: 10.1146/annurev.iy.06.040188.001343.
   PubMed Web of Science ®Google Scholar
• van der Lugt, B., A. A. van Beek, S. Aalvink, B. Meijer, B. Sovran, W. P. Vermeij, R. M. C. Brandt, W. M. de Vos, H. F. J. Savelkoul, W. T. Steegenga, et al. 2019. Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1-/Δ7 mice. Immunity & Ageing: I & A 16 (1):6. doi: 10.1186/s12979-019-0145-z.
   PubMedGoogle Scholar
• Vancamelbeke, M., and S. Vermeire. 2017. The intestinal barrier: A fundamental role in health and disease. Expert Review of Gastroenterology & Hepatology 11 (9):821–34. doi: 10.1080/17474124.2017.1343143.
   PubMed Web of Science ®Google Scholar
• Varki, A. 2008. Sialic acids in human health and disease. Trends in Molecular Medicine 14 (8):351–60. doi: 10.1016/j.molmed.2008.06.002.
   PubMed Web of Science ®Google Scholar
• Vliegenthart, J. F. G. 2017. The complexity of glycoprotein-derived glycans. Proceedings of the Japan Academy. Series B, Physical and Biological Sciences 93 (2):64–86. doi: 10.2183/pjab.93.005.
   PubMed Web of Science ®Google Scholar
• Wagh, P. V., and O. P. Bahl. 1981. Sugar residues on proteins. CRC Critical Reviews in Biochemistry 10 (4):307–77. doi: 10.3109/10409238109113602.
   PubMed Web of Science ®Google Scholar
• Wan, M. L. Y., V. A. Co, and H. El-Nezami. 2021. Dietary polyphenol impact on gut health and microbiota. Critical Reviews in Food Science and Nutrition 61 (4):690–711. doi: 10.1080/10408398.2020.1744512.
   PubMed Web of Science ®Google Scholar
• Wang, B., B. Yu, M. Karim, H. H. Hu, Y. Sun, P. McGreevy, P. Petocz, S. Held, and J. Brand-Miller. 2007a. Dietary sialic acid supplementation improves learning and memory in piglets. The American Journal of Clinical Nutrition 85 (2):561–9. doi: 10.1093/ajcn/85.2.561.
   PubMed Web of Science ®Google Scholar
• Wang, F., Y. M. Wang, Y. L. Zhao, Q. P. Zhan, P. Yu, J. F. Wang, and C. H. Xue. 2016a. Sialoglycoprotein isolated from eggs of carassius auratus ameliorates osteoporosis: An effect associated with regulation of the Wnt/β-Catenin Pathway in Rodents . Journal of Agricultural and Food Chemistry 64 (14):2875–82. doi: 10.1021/acs.jafc.5b06132.
   PubMed Web of Science ®Google Scholar
• Wang, J., X. Liu, S. Li, H. Ye, W. Luo, Q. Huang, and F. Geng. 2022. Ovomucin may be the key protein involved in the early formation of egg-white thermal gel. Food Chemistry 366:130596. doi: 10.1016/j.foodchem.2021.130596.
   PubMed Web of Science ®Google Scholar
• Wang, N., Z. Yang, J. Wu, Y. Jiang, H. Zhang, and X. Zhan. 2020. Structural elucidation of N-glycans and bioactivity of sialoglycoprotein from crucian carp eggs structure and bioactivity of crucian egg SGP. Food Bioscience 38:100776. doi: 10.1016/j.fbio.2020.100776.
   Web of Science ®Google Scholar
• Wang, Y. Z., T. Z. Shan, Z. R. Xu, J. Feng, and Z. Q. Wang. 2007b. Effects of the lactoferrin (LF) on the growth performance, intestinal microflora and morphology of weanling pigs. Animal Feed Science and Technology 135 (3–4):263–72. doi: 10.1016/j.anifeedsci.2006.07.013.
   Web of Science ®Google Scholar
• Wang, Y., T. Zou, M. Xiang, C. Jin, X. Zhang, Y. Chen, Q. Jiang, and Y. Hu. 2016b. Purification and characterization of a soluble glycoprotein from garlic (Allium sativum) and its in vitro bioactivity. Preparative Biochemistry & Biotechnology 46 (7):709–16. doi: 10.1080/10826068.2015.1135454.
   PubMed Web of Science ®Google Scholar
• Wolf, P. G., A. Biswas, S. E. Morales, C. Greening, and H. R. Gaskins. 2016. H2 metabolism is widespread and diverse among human colonic microbes. Gut Microbes 7 (3):235–45. doi: 10.1080/19490976.2016.1182288.
   PubMed Web of Science ®Google Scholar
• Wu, J., and A. Acero-Lopez. 2012. Ovotransferrin: Structure, bioactivities, and preparation. Food Research International 46 (2):480–7. doi: 10.1016/j.foodres.2011.07.012.
   Web of Science ®Google Scholar
• Wu, W., L. Lv, D. Shi, J. Ye, D. Fang, F. Guo, Y. Li, X. He, and L. Li. 2017. Protective effect of Akkermansia muciniphila against immune-mediated liver injury in a mouse model. Frontiers in Microbiology 8:1804. doi: 10.3389/fmicb.2017.01804.
   PubMed Web of Science ®Google Scholar
• Xia, G., J. Wang, S. Sun, Y. Zhao, Y. Wang, Z. Yu, S. Wang, and C. Xue. 2016. Sialoglycoproteins prepared from the eggs of Carassius auratus prevent bone loss by inhibiting the NF-κB pathway in ovariectomized rats . Food & Function 7 (2):704–12. doi: 10.1039/c5fo00955c.
   PubMed Web of Science ®Google Scholar
• Xu, R., Y. H. Lei, J. Shi, Y. J. Zhou, Y. W. Chen, and Z. J. He. 2016. Effects of lactadherin on plasma D-lactic acid and small intestinal MUC2 and claudin-1 expression levels in rats with rotavirus-induced diarrhea. Experimental and Therapeutic Medicine 11 (3):943–50. doi: 10.3892/etm.2016.3015.
   PubMed Web of Science ®Google Scholar
• Xu, X., H. Yan, J. Chen, and X. Zhang. 2011. Bioactive proteins from mushrooms. Biotechnology Advances 29 (6):667–74. doi: 10.1016/j.biotechadv.2011.05.003.
   PubMed Web of Science ®Google Scholar
• Yagi, H., N. Yasukawa, S. Y. Yu, C. T. Guo, N. Takahashi, T. Takahashi, W. Bukawa, T. Suzuki, K. H. Khoo, Y. Suzuki, et al. 2008. The expression of sialylated high-antennary N-glycans in edible bird’s nest. Carbohydrate Research 343 (8):1373–7. doi: 10.1016/j.carres.2008.03.031.
   PubMed Web of Science ®Google Scholar
• Yamamoto, K., R. Kushima, O. Kisaki, Y. Fujiyama, and H. Okabe. 2003. Combined effect of hydrogen peroxide induced oxidative stress and IL-1 alpha on IL-8 production in CaCo-2 cells (a human colon carcinoma cell line) and normal intestinal epithelial cells. Inflammation 27 (3):123–8. doi: 10.1023/a:1023813710941.
   PubMed Web of Science ®Google Scholar
• Yang, Y., H. Wu, S. Dong, W. Jin, K. Han, Y. Ren, and M. Zeng. 2018. Glycation of fish protein impacts its fermentation metabolites and gut microbiota during in vitro human colonic fermentation. Food Research International 113:189–96. doi: 10.1016/j.foodres.2018.07.015.
   PubMed Web of Science ®Google Scholar
• Yao, C. K., J. G. Muir, and P. R. Gibson. 2016. Review article: Insights into colonic protein fermentation, its modulation and potential health implications. Alimentary Pharmacology & Therapeutics 43 (2):181–96. doi: 10.1111/apt.13456.
   PubMed Web of Science ®Google Scholar
• Yao, Y., X. Y. Cai, W. D. Fei, Y. Q. Ye, M. D. Zhao, and C. H. Zheng. 2020. The role of short-chain fatty acids in immunity, inflammation and metabolism. Critical Reviews in Food Science and Nutrition 2020:1–12. doi: 10.1080/10408398.2020.1854675.
   Google Scholar
• Yoo, W., J. K. Zieba, N. J. Foegeding, T. P. Torres, C. D. Shelton, N. G. Shealy, A. J. Byndloss, S. A. Cevallos, E. Gertz, C. R. Tiffany, et al. 2021. High-fat diet-induced colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide. Science (New York, NY) 373 (6556):813–8. doi: 10.1126/science.aba3683.
   Google Scholar
• Zhang, Q.J., W. Tan, L. Yang, M. Lu, S. J. Dong, X. B. Liu, and X. Duan. 2020. Multi-omics analysis of the effects of egg ovotransferrin on the gut environment in mice: Mucosal gene expression, microbiota composition, and intestinal structural homeostasis. Molecular Nutrition & Food Research 64 (7):1901024. doi: 10.1002/mnfr.201901024.
   Web of Science ®Google Scholar
• Zhang, S., X. Lai, X. Liu, Y. Li, B. Li, X. Huang, Q. Zhang, W. Chen, L. Lin, and G. Yang. 2012a. Competitive enzyme-linked immunoassay for sialoglycoprotein of edible bird’s nest in food and cosmetics. Journal of Agricultural and Food Chemistry 60 (14):3580–5. doi: 10.1021/jf300865a.
   PubMed Web of Science ®Google Scholar
• Zhang, Y., H. R. Yin, and H. J. Lu. 2012b. Recent progress in quantitative glycoproteomics. Glycoconjugate Journal 29 (5–6):249–58. doi: 10.1007/s10719-012-9398-x.
   PubMed Web of Science ®Google Scholar
• Zhao, J., X. Zhang, H. Liu, M. A. Brown, and S. Qiao. 2019. Dietary protein and gut microbiota composition and function. Current Protein & Peptide Science 20 (2):145–54. doi: 10.2174/1389203719666180514145437.
   PubMed Web of Science ®Google Scholar
• Zhernakova, A., A. Kurilshikov, M. J. Bonder, E. F. Tigchelaar, M. Schirmer, T. Vatanen, Z. Mujagic, A. V. Vila, G. Falony, S. Vieira-Silva, LifeLines cohort study, et al. 2016. Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity. Science (New York, NY) 352 (6285):565–9. doi: 10.1126/science.aad3369.
   Google Scholar