1,127
Views
2
CrossRef citations to date
0
Altmetric
Review Articles

Review of the recent developments in metabolomics-based phytochemical research

, , ORCID Icon, ORCID Icon & ORCID Icon

References

  • Abedi, F., B. M. Razavi, and H. Hosseinzadeh. 2020. A review on gentisic acid as a plant derived phenolic acid and metabolite of aspirin: Comprehensive pharmacology, toxicology, and some pharmaceutical aspects. Phytotherapy Research 34 (4):729–13. doi: 10.1002/ptr.6573.
  • Aggarwal, B. B., A. Kumar, and A. C. Bharti. 2003. Anticancer potential of curcumin: Preclinical and clinical studies. Anticancer Research 23 (1A):363–98.
  • Asakura, H., and T. Kitahora. 2018. Antioxidants and polyphenols in inflammatory bowel disease: ulcerative colitis and Crohn Disease. Chapter 23. In Polyphenols: Prevention and treatment of human disease, 279–292. New York: Elsevier. doi: 10.1016/B978-0-12-813008-7.00023-0.
  • Asnin, L., and S. W. Park. 2015. Isolation and analysis of bioactive compounds in capsicum peppers. Critical Reviews in Food Science and Nutrition 55 (2):254–89. doi: 10.1080/10408398.2011.652316.
  • Astley, S. B. 2003. Antioxidants | Role of antioxidant nutrients in defense systems. In Encyclopedia of food sciences and nutrition, 2nd ed., 282–9. New York: Elsevier. doi: 10.1016/b0-12-227055-x/00056-0.
  • Babu, P. V. A., D. Liu, and E. R. Gilbert. 2013. Recent advances in understanding the anti-diabetic actions of dietary flavonoids. The Journal of Nutritional Biochemistry 24 (11):1777–89. doi: 10.1016/j.jnutbio.2013.06.003.
  • Bamba, T., and E. Fukusaki. 2006. Technical problems and practical operations in plant metabolomics. Journal of Pesticide Science 31 (3):300–4. doi: 10.1584/jpestics.31.300.
  • Bendini, A., L. Cerretani, A. Carrasco-Pancorbo, A. M. Gómez-Caravaca, A. Segura-Carretero, A. Fernández-Gutiérrez, and G. Lercker. 2007. Phenolic molecules in virgin olive oils: A survey of their sensory properties, health effects, antioxidant activity and analytical methods. An overview of the last decade. Molecules (Basel, Switzerland) 12 (8):1679–719. doi: 10.3390/12081679.
  • Bentley, J., J. P. Moore, and J. M. Farrant. 2019. Metabolomics as a complement to phylogenetics for assessing intraspecific boundaries in the desiccation-tolerant medicinal shrub Myrothamnus flabellifolia (Myrothamnaceae). Phytochemistry 159:127–36. doi: 10.1016/j.phytochem.2018.12.016.
  • Berendschot, T. T. J. M., and J. Plat. 2014. Plant stanol and sterol esters and macular pigment optical density. In Handbook of nutrition, diet and the eye, eds. V. R. Preedy, 441–9. Waltham, MA: Academic Press. doi: 10.1016/B978-0-12-401717-7.00044-7.
  • Bhagwat, S., D. B. Haytowitz, and J. M. Holden. 2011. USDA database for the flavonoid content of selected foods. Release 3.1. Prepared by USDA Database. U.S. Department of Argiculture, 1–156.
  • Bojko, B., F. Mirnaghi, and J. Pawliszyn. 2011. Solid-phase microextraction: A multi-purpose microtechnique. Bioanalysis 3 (17):1895–9. doi: 10.4155/bio.11.210.
  • Castro-Moretti, F. R., I. N. Gentzel, D. Mackey, and A. P. Alonso. 2020. Metabolomics as an emerging tool for the study of plant–Pathogen interactions. Metabolites 10 (2):52. doi: 10.3390/metabo10020052.
  • Chai, T. T., K. F. Ooh, Y. Quah, and F. C. Wong. 2015. Edible freshwater macrophytes: A source of anticancer and antioxidative natural products—A mini-review. Phytochemistry Reviews 14 (3):443–57. doi: 10.1007/s11101-015-9399-z.
  • Chao, P. C., C. C. Hsu, and M. C. Yin. 2009. Anti-inflammatory and anti-coagulatory activities of caffeic acid and ellagic acid in cardiac tissue of diabetic mice. Nutrition and Metabolism 6:1–8. doi: 10.1186/1743-7075-6-33.
  • Chong, K. P., S. Rossall, and M. Atong. 2011. HPC fingerprints and in vitro antimicrobial activity of syringic acid, caffeic acid and 4-hydroxybenzoic acid against Ganoderma boninense. Journal of Applied Sciences 11 (13):2284–91. doi: 10.3923/jas.2011.2284.2291.
  • Clarke, J. D., R. H. Dashwood, and E. Ho. 2008. Multi-targeted prevention of cancer by sulforaphane. Cancer Letters 269 (2):291–304. doi: 10.1016/j.canlet.2008.04.018.
  • Cocuron, J. C., B. Anderson, A. Boyd, and A. P. Alonso. 2014. Targeted metabolomics of Physaria fendleri, an industrial crop producing hydroxy fatty acids. Plant & Cell Physiology 55 (3):620–33. doi: 10.1093/pcp/pcu011.
  • Colak, N., H. Torun, J. Gruz, M. Strnad, I. Hermosín-Gutiérrez, S. Hayirlioglu-Ayaz, and F. A. Ayaz. 2016. Bog bilberry phenolics, antioxidant capacity and nutrient profile. Food Chemistry 201:339–49. doi: 10.1016/j.foodchem.2016.01.062.
  • Cole, G. M., B. Teter, and S. A. Frautschy. 2007. Neuroprotective effects of curcumin. In Advances in experimental medicine and biology, edited by B. B. Aggarwal, Y.-J. Surh, and S. Shishodia, Vol. 595, 197–212. New York: Springer. doi: 10.1007/978-0-387-46401-5_8.
  • Commisso, M., P. Strazzer, K. Toffali, M. Stocchero, and F. Guzzo. 2013. Untargeted metabolomics: An emerging approach to determine the composition of herbal products. Computational and Structural Biotechnology Journal 4:e201301007. doi: 10.5936/csbj.201301007.
  • Dabeek, W. M., and M. V. Marra. 2019. Dietary quercetin and kaempferol: Bioavailability and potential cardiovascular-related bioactivity in humans. Nutrients 11 (10):2288. doi: 10.3390/nu11102288.
  • Dan, M., M. Su, X. Gao, T. Zhao, A. Zhao, G. Xie, Y. Qiu, M. Zhou, Z. Liu, and W. Jia. 2008. Metabolite profiling of Panax notoginseng using UPLC-ESI-MS. Phytochemistry 69 (11):2237–44. doi: 10.1016/j.phytochem.2008.04.015.
  • Davidson, R. L., R. J. M. Weber, H. Liu, A. Sharma-Oates, and M. R. Viant. 2016. Galaxy-M: A galaxy workflow for processing and analyzing direct infusion and liquid chromatography mass spectrometry-based metabolomics data. GigaScience 5:10. doi: 10.1186/s13742-016-0115-8.
  • De Lourdes Reyes-Escogido, M., E. G. Gonzalez-Mondragon, and E. Vazquez-Tzompantzi. 2011. Chemical and pharmacological aspects of capsaicin. Molecules (Basel, Switzerland) 16 (2):1253–70. doi: 10.3390/molecules16021253.
  • Dhillon, N., B. B. Aggarwal, R. A. Newman, R. A. Wolff, A. B. Kunnumakkara, J. L. Abbruzzese, C. S. Ng, V. Badmaev, and R. Kurzrock. 2008. Phase II trial of curcumin in patients with advanced pancreatic cancer. Clinical Cancer Research 14 (14):4491–9. doi: 10.1158/1078-0432.CCR-08-0024.
  • Dixon, R. A., D. Y. Xie, and S. B. Sharma. 2005. Proanthocyanidins-A final frontier in flavonoid research? New Phytologist 165 (1):9–28. doi: 10.1111/j.1469-8137.2004.01217.x.
  • Drouin, N., S. Rudaz, and J. Schappler. 2017. Sample preparation for polar metabolites in bioanalysis. The Analyst 143 (1):16–20. doi: 10.1039/c7an01333g.
  • Dunn, W. B., and T. Hankemeier. 2013. Mass spectrometry and metabolomics: Past, present and future. Metabolomics 9 (S1):1–3. doi: 10.1007/s11306-013-0507-z.
  • Ebrahimnejad, H., T. Burkholz, and C. Jacob. 2014. Flavanols and proanthocyanidins. In Recent advances in redox active plant and microbial products: From basic chemistry to widespread applications in medicine and agriculture, eds. C. Jacob, G. Kirsch, A. Slusarenko, P. G. Winyard, and T. Burkholz, 211–32. New York: Springer. doi: 10.1007/978-94-017-8953-0_8.
  • Epelbaum, R., M. Schaffer, B. Vizel, V. Badmaev, and G. Bar-Sela. 2010. Curcumin and gemcitabine in patients with advanced pancreatic cancer. Nutrition and Cancer 62 (8):1137–41. doi: 10.1080/01635581.2010.513802.
  • Erdman, J., J. Wills, and D. Finley. 2000. Chocolate: Modern science investigates an ancient medicine. Foreword. Journal of Nutrition 130 (8 Suppl):121–5. doi: 10.1089/109662000416311.
  • Espín, J. C., M. T. García-Conesa, and F. A. Tomás-Barberán. 2007. Nutraceuticals: Facts and fiction. Phytochemistry 68 (22–24):2986–3008. doi: 10.1016/j.phytochem.2007.09.014.
  • Fahey, J. W., X. Haristoy, P. M. Dolan, T. W. Kensler, I. Scholtus, K. K. Stephenson, P. Talalay, and A. Lozniewski. 2002. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo [a] pyrene- induced stomach tumors. Proceedings of the National Academy of Sciences of the United States of America 99 (11):7610–5. doi: 10.1073/pnas.112203099.
  • Farag, M. A., H. A. Gad, A. G. Heiss, and L. A. Wessjohann. 2014. Metabolomics driven analysis of six Nigella species seeds via UPLC-qTOF-MS and GC-MS coupled to chemometrics. Food Chemistry 151:333–42. doi: 10.1016/j.foodchem.2013.11.032.
  • Fiehn, O., S. P. Putri, K. Saito, R. M. Salek, and D. J. Creek. 2015. Metabolomics continues to expand: Highlights from the 2015 metabolomics conference. Metabolomics 11 (5):1036–40. doi: 10.1007/s11306-015-0846-z.
  • Fiehn, O., D. Robertson, J. Griffin, M. van der Werf, B. Nikolau, N. Morrison, L. W. Sumner, R. Goodacre, N. W. Hardy, C. Taylor, et al. 2007. The metabolomics standards initiative (MSI). Metabolomics 3 (3):175–8. doi: 10.1007/s11306-007-0070-6.
  • Fiehn, O., G. Wohlgemuth, M. Scholz, T. Kind, D. Y. Lee, Y. Lu, S. Moon, and B. Nikolau. 2008. Quality control for plant metabolomics: Reporting MSI-compliant studies. The Plant Journal: For Cell and Molecular Biology 53 (4):691–704. doi: 10.1111/j.1365-313X.2007.03387.x.
  • Folberth, J., K. Begemann, O. Jöhren, M. Schwaninger, and A. Othman. 2020. MS2 and LC libraries for untargeted metabolomics: Enhancing method development and identification confidence. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 1145:122105. doi: 10.1016/j.jchromb.2020.122105.
  • Franceschi, P., R. Mylonas, N. Shahaf, M. Scholz, P. Arapitsas, D. Masuero, G. Weingart, S. Carlin, U. Vrhovsek, F. Mattivi, et al. 2014. MetaDB a data processing workflow in untargeted MS-based metabolomics experiments. Frontiers in Bioengineering and Biotechnology 2:72. doi: 10.3389/fbioe.2014.00072.
  • French, K. E., J. Harvey, and J. S. O. McCullagh. 2018. Targeted and untargeted metabolic profiling of wild grassland plants identifies antibiotic and anthelmintic compounds targeting pathogen physiology. Metabolism and Reproduction. Scientific Reports 8 (1):1695. doi: 10.1038/s41598-018-20091-z.
  • Fujimura, Y., D. Miura, and H. Tachibana. 2017. A phytochemical-sensing strategy based on mass spectrometry imaging and metabolic profiling for understanding the functionality of the medicinal herb green tea. Molecules 22 (10):1621. doi: 10.3390/molecules22101621.
  • García-Niño, W. R., and C. Zazueta. 2015. Ellagic acid: Pharmacological activities and molecular mechanisms involved in liver protection. Pharmacological Research 97:84–103. doi: 10.1016/j.phrs.2015.04.008.
  • Ghimire, B. K., B. Ghimire, C. Y. Yu, and I. M. Chung. 2019. Allelopathic and autotoxic effects of medicago sativa—Derived allelochemicals. Plants 8 (7):233. doi: 10.3390/plants8070233.
  • Giupponi, L., V. Leoni, R. Pavlovic, and A. Giorgi. 2020. Influence of altitude on phytochemical composition of hemp inflorescence: A metabolomic approach. Molecules 25 (6):1381. doi: 10.3390/molecules25061381.
  • Gonulalan, E. M., E. Nemutlu, O. Bayazeid, E. Koçak, F. N. Yalçın, and L. O. Demirezer. 2020. Metabolomics and proteomics profiles of some medicinal plants and correlation with BDNF activity. Phytomedicine 74:152920. doi: 10.1016/j.phymed.2019.152920.
  • González-Gallego, J., M. V. García-Mediavilla, S. Sánchez-Campos, and M. J. Tuñón. 2018. Anti-inflammatory, immunomodulatory, and prebiotic properties of dietary flavonoids. In Polyphenols: prevention and treatment of human disease, eds. R. R. Watson, V. R. Preedy, and S. Zibadi, 327–45. London, UK: Academic Press. doi: 10.1016/B978-0-12-813008-7.00028-X.
  • González-Riano, C., D. Dudzik, A. Garcia, A. Gil-de-la-Fuente, A. Gradillas, J. Godzien, Á. López-Gonzálvez, F. Rey-Stolle, D. Rojo, F. J. Ruperez, et al. 2020. Recent developments along the analytical process for metabolomics workflows. Analytical Chemistry 92 (1):203–26. doi: 10.1021/acs.analchem.9b04553.
  • Goodacre, R., D. Broadhurst, A. K. Smilde, B. S. Kristal, J. D. Baker, R. Beger, C. Bessant, S. Connor, G. Capuani, A. Craig, et al. 2007. Proposed minimum reporting standards for data analysis in metabolomics. Metabolomics 3 (3):231–41. doi: 10.1007/s11306-007-0081-3.
  • Gross, M. L., and M. Przybylski. 2010. Focus on affinity mass spectrometry. Journal of the American Society for Mass Spectrometry 21 (10):I1–I2. doi: 10.1016/j.jasms.2010.08.005.
  • Gruz, J., F. A. Ayaz, H. Torun, and M. Strnad. 2011. Phenolic acid content and radical scavenging activity of extracts from medlar (Mespilus germanica L.) fruit at different stages of ripening. Food Chemistry 124 (1):271–7. doi: 10.1016/j.foodchem.2010.06.030.
  • Hajlaoui, H., S. Arraouadi, H. Mighri, M. Chaaibia, N. Gharsallah, G. Ros, G. Nieto, and A. Kadri. 2019. Phytochemical constituents and antioxidant activity ofoudneya africana l. Leaves extracts: Evaluation effects on fatty acids and proteins oxidation of beef burger during refrigerated storage. Antioxidants 8 (10):442. doi: 10.3390/antiox8100442.
  • Han, D. H., M. J. Lee, and J. H. Kim. 2006. Antioxidant and apoptosis-inducing activities of ellagic acid. Anticancer Research 26 (5A):3601–6.
  • Harwood, M., B. Danielewska-Nikiel, J. F. Borzelleca, G. W. Flamm, G. M. Williams, and T. C. Lines. 2007. A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 45 (11):2179–205. doi: 10.1016/j.fct.2007.05.015.
  • He, F., Q. H. Pan, Y. Shi, and C. Q. Duan. 2008. Biosynthesis and genetic regulation of proanthocyanidins in plants. Molecules (Basel, Switzerland) 13 (10):2674–703. doi: 10.3390/molecules13102674.
  • Holmes, E., I. D. Wilson, and J. K. Nicholson. 2008. Metabolic phenotyping in health and disease. Cell 134 (5):714–7. doi: 10.1016/j.cell.2008.08.026.
  • Holmes, E., J. Kinross, G. R. Gibson, R. Burcelin, W. Jia, S. Pettersson, and J. K. Nicholson. 2012. Therapeutic modulation of microbiota-host metabolic interactions. Science Translational Medicine 4 (137):137rv6. www.ScienceTranslationalMedicine.org
  • Hu, Q., H. Tang, and Y. Wang. 2020. Challenges in analysis of hydrophilic metabolites using chromatography coupled with mass spectrometry. Journal of Analysis and Testing 4 (3):140–62. doi: 10.1007/s41664-020-00126-z.
  • Khadem, S., and R. J. Marles. 2010. Monocyclic phenolic acids; hydroxy- and polyhydroxybenzoic acids: Occurrence and recent bioactivity studies. Molecules (Basel, Switzerland) 15 (11):7985–8005. doi: 10.3390/molecules15117985.
  • Kinross, J. M., A. C. von Roon, E. Holmes, A. Darzi, J. K. Nicholson, and F. Path. 2008. The human gut microbiome: Implications for future health care. Current Gastroenterology Reports 10 (4):396–403.
  • Knolhoff, A. M., J. H. Callahan, and T. R. Croley. 2014. Mass accuracy and isotopic abundance measurements for HR-MS instrumentation: Capabilities for non-targeted analyses. Journal of the American Society for Mass Spectrometry 25 (7):1285–94. doi: 10.1007/s13361-014-0880-5.
  • Kobata, K., M. Sugawara, M. Mimura, S. Yazawa, and T. Watanabe. 2013. Potent production of capsaicinoids and capsinoids by capsicum peppers. Journal of Agricultural and Food Chemistry 61 (46):11127–32. doi: 10.1021/jf403553w.
  • Kotecha, R., A. Takami, and J. L. Espinoza. 2016. Dietary phytochemicals and cancer chemoprevention: A review of the clinical evidence. Oncotarget 7 (32):52517–29. doi: 10.18632/oncotarget.9593.
  • Koushki, M., N. Amiri-Dashatan, N. Ahmadi, H. A. Abbaszadeh, and M. Rezaei-Tavirani. 2018. Resveratrol: A miraculous natural compound for diseases treatment. Food Science & Nutrition 6 (8):2473–90. doi: 10.1002/fsn3.855.
  • Krochmal, R., M. Hardy, S. Bowerman, Q.-Y. Lu, H.-J. Wang, R. Elashoff, and D. Heber. 2004. Phytochemical assays of commercial botanical dietary supplements. Evidence-Based Complementary and Alternative Medicine: eCAM 1 (3):305–13. doi: 10.1093/ecam/neh040.
  • Kulkarni, Y. A., M. S. Garud, M. J. Oza, K. H. Barve, and A. B. Gaikwad. 2016. Diabetes, diabetic complications, and flavonoids. In Fruits, vegetables, and herbs: Bioactive foods in health promotion, eds. R. R. Watson and V. R. Preedy, 77–104. London, UK: Academic Press. doi: 10.1016/B978-0-12-802972-5.00005-6.
  • Lee, Y. H., B. Kim, S. R. Hwang, K. Kim, and J. H. Lee. 2018. Rapid characterization of metabolites in soybean using ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-ESI-Q-TOF-MS/MS) and screening for α-glucosidase inhibitory and antioxidant properties through different solvent systems. Journal of Food and Drug Analysis 26 (1):277–91. doi: 10.1016/j.jfda.2017.05.005.
  • Li, Y., L. Zhang, H. Wu, X. Wu, L. Ju, and Y. Zhang. 2014. Metabolomic study to discriminate the different Bulbus fritillariae species using rapid resolution liquid chromatography-quadrupole time-of-flight mass spectrometry coupled with multivariate statistical analysis. Analytical Methods 6 (7):2247–59. doi: 10.1039/c3ay41928b.
  • Lindsay, J., D. Laurin, R. Verreault, R. Hébert, B. Helliwell, G. B. Hill, and I. McDowell. 2002. Risk factors for Alzheimer’s disease: A prospective analysis from the Canadian Study of Health and Aging. American Journal of Epidemiology 156 (5):445–53. doi: 10.1093/aje/kwf074.
  • Liu, R. H. 2012. Health bene fits of phytochemicals in whole foods. In Nutritional health: strategies for disease prevention, eds. N. J. Temple, T. Wilson, and D. R. Jacobs, Jr., 3rd ed., 293–310. New York: Springer. doi: 10.1007/978-1-61779-894-8_13.
  • Liu, G. J., G. H. Xiao, N. J. Liu, D. Liu, P. S. Chen, Y. M. Qin, and Y. X. Zhu. 2015. Targeted lipidomics studies reveal that linolenic acid promotes cotton fiber elongation by activating phosphatidylinositol and phosphatidylinositol monophosphate biosynthesis. Molecular Plant 8 (6):911–21. doi: 10.1016/j.molp.2015.02.010.
  • Lu, B., and Y. Zhao. 2017. Photooxidation of phytochemicals in food and control: A review. Annals of the New York Academy of Sciences 1398 (1):72–82. doi: 10.1111/nyas.13377.
  • Luo, X. J., J. Peng, and Y. J. Li. 2011. Recent advances in the study on capsaicinoids and capsinoids. European Journal of Pharmacology 650 (1):1–7. doi: 10.1016/j.ejphar.2010.09.074.
  • Maia, M., A. E. N. Ferreira, G. Laureano, A. P. Marques, V. M. Torres, A. B. Silva, A. R. Matos, C. Cordeiro, A. Figueiredo, and M. Sousa Silva. 2019. Vitis vinifera ‘Pinot noir’ leaves as a source of bioactive nutraceutical compounds. Food & Function 10 (7):3822–7. doi: 10.1039/c8fo02328j.
  • Manetti, C., C. Bianchetti, L. Casciani, C. Castro, M. E. Di Cocco, A. Miccheli, M. Motto, and F. Conti. 2006. A metabonomic study of transgenic maize (Zea mays) seeds revealed variations in osmolytes and branched amino acids. Journal of Experimental Botany 57 (11):2613–25. doi: 10.1093/jxb/erl025.
  • Mangano, K. M., H. L. Hutchins-Wiese, A. M. Kenny, S. J. Walsh, R. H. Abourizk, R. S. Bruno, R. Lipcius, P. Fall, A. Kleppinger, L. Kenyon-Pesce, et al. 2013. Soy proteins and isoflavones reduce interleukin-6 but not serum lipids in older women: A randomized controlled trial. Nutrition Research (New York, N.Y.) 33 (12):1026–33. doi: 10.1016/j.nutres.2013.08.009.
  • Mareya, C. R., F. Tugizimana, L. A. Piater, N. E. Madala, P. A. Steenkamp, and I. A. Dubery. 2019. Untargeted metabolomics reveal defensome-related metabolic reprogramming in sorghum bicolor against infection by Burkholderia andropogonis. Metabolites 9 (1):8. doi: 10.3390/metabo9010008.
  • Marti, G., P. Joulia, A. Amiel, B. Fabre, B. David, N. Fabre, and C. Fiorini-Puybaret. 2019. Comparison of the phytochemical composition of Serenoa repens extracts by a multiplexed metabolomic approach. Molecules 24 (12):2208. doi: 10.3390/molecules24122208.
  • Masike, K., B. S. Khoza, P. A. Steenkamp, E. Smit, I. A. Dubery, and N. E. Madala. 2017. A metabolomics-guided exploration of the phytochemical constituents of Vernonia fastigiata with the aid of pressurized hot water extraction and liquid chromatography-mass spectrometry. Molecules 22 (8):1200. doi: 10.3390/molecules22081200.
  • Masson, J., E. Liberto, H. Brevard, C. Bicchi, and P. Rubiolo. 2014. A metabolomic approach to quality determination and authentication of raw plant material in the fragrance field. Iris rhizomes: A case study. Journal of Chromatography. A 1368:143–54. doi: 10.1016/j.chroma.2014.09.076.
  • Mediani, A., F. Abas, A. Khatib, H. Maulidiani, K. Shaari, Y. H. Choi, and N. H. Lajis. 2012. 1H-NMR-based metabolomics approach to understanding the drying effects on the phytochemicals in Cosmos caudatus. Food Research International 49 (2):763–70. doi: 10.1016/j.foodres.2012.09.022.
  • Meier, R., C. Ruttkies, H. Treutler, and S. Neumann. 2017. Bioinformatics can boost metabolomics research. Journal of Biotechnology 261:137–41. doi: 10.1016/j.jbiotec.2017.05.018.
  • Mezzomo, N., and S. R. S. Ferreira. 2016. Carotenoids functionality, sources, and processing by supercritical technology: A review. Journal of Chemistry 2016:1–16. doi: 10.1155/2016/3164312.
  • Miadoková, E. 2009. Isoflavonoids - An overview of their biological activities and potential health benefits. Interdisciplinary Toxicology 2 (4):211–8. doi: 10.2478/v10102-009-0021-3.
  • Nakabayashi, R., and K. Saito. 2013. Metabolomics for unknown plant metabolites. Analytical and Bioanalytical Chemistry 405 (15):5005–11. doi: 10.1007/s00216-013-6869-2.
  • Nankar, R. P., M. Raman, and M. Doble. 2016. Nanoformulations of polyphenols for prevention and treatment of cardiovascular and metabolic disorders. In Emulsions, ed. A. M. Grumezescu, 107–51. London: Elsevier. doi: 10.1016/b978-0-12-804306-6.00004-0.
  • Ndiaye, M., C. Philippe, H. Mukhtar, and N. Ahmad. 2011. The grape antioxidant resveratrol for skin disorders: Promise, prospects, and challenges. Archives of Biochemistry and Biophysics 508 (2):164–70. doi: 10.1016/j.abb.2010.12.030.
  • Neilson, A. P., K. M. Goodrich, and M. G. Ferruzzi. 2017. Bioavailability and metabolism of bioactive compounds from foods. In Nutrition in the prevention and treatment of disease, eds. A. M. Coulston, C. J. Boushey, 301–19. Burlington, MA: Academic Press. doi: 10.1016/B978-0-12-802928-2.00015-1.
  • Nicholls, A. W. 2012. Realising the potential of metabolomics. Bioanalysis 4 (18):2195–7. doi: 10.4155/bio.12.209.
  • Nieves, J. W. 2013. Alternative therapy through nutrients and nutraceuticals. In Osteoporosis: fourth edition , eds. R. Marcus, D. Dempster, J. Cauley, and D. Feldman. London: Elsevier. doi: 10.1016/B978-0-12-415853-5.00074-1.
  • Olthof, M. R., P. C. H. Hollman, and M. B. Katan. 2001. Chlorogenic acid and caffeic acid are absorbed in humans. The Journal of Nutrition 131 (1):66–71. doi: 10.1093/jn/131.1.66.
  • Owis, A. I. 2015. Broccoli; the green beauty: A review. Journal of Pharmaceutical Sciences and Research 7 (9):696–703.
  • Pandohee, J., B. J. Holland, B. Li, T. Tsuzuki, P. G. Stevenson, N. W. Barnett, J. R. Pearson, O. A. H. Jones, and X. A. Conlan. 2015. Screening of cannabinoids in industrial-grade hemp using two-dimensional liquid chromatography coupled with acidic potassium permanganate chemiluminescence detection. Journal of Separation Science 38 (12):2024–32. doi: 10.1002/jssc.201500088.
  • Pandohee, J., and O. A. H. Jones. 2016. Evaluation of new micro solid-phase extraction cartridges for on-column derivatisation reactions. Analytical Methods 8 (8):1765–9. doi: 10.1039/C5AY02618K.
  • Pandohee, J., R. J. Rees, M. J. S. Spencer, A. Raynor, and O. A. H. Jones. 2019. Combining computational and experimental approaches to select chromophores to enable the detection of fatty acids: Via HPLC. Analytical Methods 11 (23):2952–9. doi: 10.1039/C9AY00616H.
  • Pandohee, J., P. G. Stevenson, X. A. Conlan, X. R. Zhou, and O. A. H. Jones. 2015. Off-line two-dimensional liquid chromatography for metabolomics: An example using Agaricus bisporus mushrooms exposed to UV irradiation. Metabolomics 11 (4):939–51. doi: 10.1007/s11306-014-0749-4.
  • Pandohee, J., P. Stevenson, X.-R. Zhou, M. Spencer, and O. Jones. 2015. Multi-dimensional liquid chromatography and metabolomics, are two dimensions better than one? Current Metabolomics 3 (1):10–20. doi: 10.2174/2213235X03666150403231202.
  • Prasad, S., S. C. Gupta, A. K. Tyagi, and B. B. Aggarwal. 2014. Curcumin, a component of golden spice: From bedside to bench and back. Biotechnology Advances 32 (6):1053–64. doi: 10.1016/j.biotechadv.2014.04.004.
  • Prasain, J. K., S. Barnes, and J. Michael Wyss. 2018. Analyzing ingredients in dietary supplements and their metabolites. Chapter 24. In Polyphenols: Mechanisms of action in human health and disease, eds. R. R. Watson, V. R. Preedy, and S. Zibadi, 337–46. London, UK: Academic Press. doi: 10.1016/B978-0-12-813006-3.00024-6.
  • Qiu, F., D. D. Fine, D. J. Wherritt, Z. Lei, and L. W. Sumner. 2016. PlantMAT: A metabolomics tool for predicting the specialized metabolic potential of a system and for large-scale metabolite identifications. Analytical Chemistry 88 (23):11373–83. doi: 10.1021/acs.analchem.6b00906.
  • Rodriguez-Casado, A. 2016. The health potential of fruits and vegetables phytochemicals: notable examples. Critical Reviews in Food Science and Nutrition 56 (7):1097–107. doi: 10.1080/10408398.2012.755149.
  • Roessner, U., and J. Bowne. 2009. What is metabolomics all about? BioTechniques 46 (5):363–5. doi: 10.2144/000113133.
  • Roessner, U., J. H. Patterson, M. G. Forbes, G. B. Fincher, P. Langridge, and A. Bacic. 2006. An investigation of boron toxicity in Barley using metabolomics. Plant Physiology 142 (3):1087–101. doi: 10.1104/pp.106.084053.
  • Saldanha, E., N. Joseph, R. Ravi, A. Kumar, V. Shetty, R. Fayad, and M. S. Baliga. 2013. Polyphenols in the prevention of acute pancreatitis: Preclinical observations. In Polyphenols in human health and disease, eds. R. R. Watson, V. R. Preedy, and S. Zibadi, vol. 1. London: Elsevier. doi: 10.1016/B978-0-12-398456-2.00031-1.
  • Salehi, B., A. Mishra, M. Nigam, B. Sener, M. Kilic, M. Sharifi-Rad, P. Fokou, N. Martins, and J. Sharifi-Rad. 2018. Resveratrol: A double-edged sword in health benefits. Biomedicines 6 (3):91–20. doi: 10.3390/biomedicines6030091.
  • Salek, R. M., S. Neumann, D. Schober, J. Hummel, K. Billiau, J. Kopka, E. Correa, T. Reijmers, A. Rosato, L. Tenori, et al. 2015. COordination of Standards in MetabOlomicS (COSMOS): facilitating integrated metabolomics data access. Metabolomics: Official Journal of the Metabolomic Society 11 (6):1587–97. doi: 10.1007/s11306-015-0810-y.
  • Salek, R. M., C. Steinbeck, M. R. Viant, R. Goodacre, and W. B. Dunn. 2013. The role of reporting standards for metabolite annotation and identification in metabolomic studies. GigaScience 2 (1):13. doi: 10.1186/2047-217X-2-13.
  • Salem, M. A., L. P. De Souza, A. Serag, A. R. Fernie, M. A. Farag, S. M. Ezzat, and S. Alseekh. 2020. Metabolomics in the context of plant natural products research: From sample preparation to metabolite analysis. Metabolites 10 (1):37. doi: 10.3390/metabo10010037.
  • Sanclemente, T., I. Marques-Lopes, J. Puzo, and A. L. García-Otín. 2009. Role of naturally-occurring plant sterols on intestinal cholesterol absorption and plasmatic levels. Journal of Physiology and Biochemistry 65 (1):87–98. doi: 10.1007/BF03165972.
  • Santana-Gálvez, J., and D. Jacobo-Velázquez. 2018. Classification of phenolic compounds. In Phenolic compounds in food: Characterization and analysis, eds. L. M. L. Nollet and J. A. Gutierrez-Uribe, 3–21. Boca Raton, FL: CRC Press. doi: 10.1201/9781315120157-1.
  • Sarrou, E., L.-P. Giassafaki, D. Masuero, D. Perenzoni, I. S. Vizirianakis, M. Irakli, P. Chatzopoulou, and S. Martens. 2018. Metabolomics assisted fingerprint of Hypericum perforatum chemotypes and assessment of their cytotoxic activity. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 114:325–33. doi: 10.1016/j.fct.2018.02.057.
  • Sato, Y., S. Itagaki, T. Kurokawa, J. Ogura, M. Kobayashi, T. Hirano, M. Sugawara, and K. Iseki. 2011. In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid. International Journal of Pharmaceutics 403 (1–2):136–8. doi: 10.1016/j.ijpharm.2010.09.035.
  • Savitski, M. M., F. Fischer, T. Mathieson, G. Sweetman, M. Lang, and M. Bantscheff. 2010. Targeted data acquisition for improved reproducibility and robustness of proteomic mass spectrometry assays. Journal of the American Society for Mass Spectrometry 21 (10):1668–79. doi: 10.1016/j.jasms.2010.01.012.
  • Schnitzler, J. P., J. Madlung, A. Rose, and H. Ulrich Seitz. 1992. Biosynthesis of p-hydroxybenzoic acid in elicitor-treated carrot cell cultures. Planta 188 (4):594–600. doi: 10.1007/BF00197054.
  • Schrimpe-Rutledge, A. C., S. G. Codreanu, S. D. Sherrod, and J. A. McLean. 2016. Untargeted metabolomics strategies: Challenges and emerging directions. Journal of the American Society for Mass Spectrometry 27 (12):1897–905. doi: 10.1007/s13361-016-1469-y.
  • Seeram, N. P., L. S. Adams, M. L. Hardy, and D. Heber. 2004. Total cranberry extract versus its phytochemical constituents: Antiproliferative and synergistic effects against human tumor cell lines. Journal of Agricultural and Food Chemistry 52 (9):2512–7. doi: 10.1021/jf0352778.
  • Shahidi, F., P. Ambigaipalan, and A. Chandrasekara. 2017. Recent advances in phytochemicals in fruits and vegetables. In Fruit and vegetable phytochemicals: Chemistry and human health, eds. E. M. Yahia, 2nd ed., 1323–56. New York: Wiley. doi: 10.1002/9781119158042.ch71.
  • Sharma, R. A., H. R. McLelland, K. A. Hill, C. R. Ireson, S. A. Euden, M. M. Manson, M. Pirmohamed, L. J. Marnett, A. J. Gescher, and W. P. Steward. 2001. Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 7 (7):1894–900.
  • Sharma, A., P. Sharma, H. Singh Tuli, and A. K. Sharma. 2018. Phytochemical and pharmacological properties of flavonols. ELS 2018:1–12. doi: 10.1002/9780470015902.a0027666.
  • Sierra, H., M. Cordova, C. S. J. Chen, and M. Rajadhyaksha. 2015. Confocal imaging-guided laser ablation of basal cell carcinomas: An ex vivo study. The Journal of Investigative Dermatology 135 (2):612–5. doi: 10.1038/jid.2014.371.
  • Song, Q., A. H. Zhang, G. L. Yan, L. Liu, and X. J. Wang. 2017. Technological advances in current metabolomics and its application in tradition Chinese medicine. RSC Advances 7 (84):53516–24. doi: 10.1039/C7RA02056B.
  • Spagnuolo, C., G. L. Russo, I. E. Orhan, S. Habtemariam, M. Daglia, A. Sureda, S. F. Nabavi, K. P. Devi, M. R. Loizzo, R. Tundis, et al. 2015. Genistein and cancer: Current status, challenges, and future directions. Advances in Nutrition (Bethesda, MD) 6 (4):408–19. doi: 10.3945/an.114.008052.
  • Srivastava, N., A. S. Chauhan, and B. Sharma. 2012. Isolation and characterization of some phytochemicals from indian traditional plants. Biotechnology Research International 2012:549850–8. doi: 10.1155/2012/549850.
  • Sumner, L. W., A. Amberg, D. Barrett, M. H. Beale, R. Beger, C. A. Daykin, T. W.-M. Fan, O. Fiehn, R. Goodacre, J. L. Griffin, et al. 2007. Proposed minimum reporting standards for chemical analysis Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI)). Metabolomics: Official Journal of the Metabolomic Society 3 (3):211–21. doi: 10.1007/s11306-007-0082-2.
  • Sumner, L. W., P. Mendes, and R. A. Dixon. 2003. Plant metabolomics: Large-scale phytochemistry in the functional genomics era. Phytochemistry 62 (6):817–36. doi: 10.1016/S0031-9422(02)00708-2.
  • Szczuka, D., A. Nowak, M. Zakłos-Szyda, E. Kochan, G. Szymańska, I. Motyl, and J. Blasiak. 2019. American ginseng (Panax quinquefolium L.) as a source of bioactive phytochemicals with pro-health properties. Nutrients 11 (5):1041. doi: 10.3390/nu11051041.
  • Taku, K., K. Umegaki, Y. Sato, Y. Taki, K. Endoh, and S. Watanabe. 2007. Erratum: Soy isoflavones lower serum total and LDL cholesterol in humans: A meta-analysis of 11 randomized controlled trials (American Journal of Clinical Nutrition (2007) 85, (1148-1156)). American Journal of Clinical Nutrition 86 (3):809.
  • Tebani, A., C. Afonso, and S. Bekri. 2018. Advances in metabolome information retrieval: Turning chemistry into biology. Part I: Analytical chemistry of the metabolome. Journal of Inherited Metabolic Disease 41 (3):379–91. doi: 10.1007/s10545-017-0074-y.
  • Thompson, J. W., K. J. Adams, J. Adamski, Y. Asad, D. Borts, J. A. Bowden, G. Byram, V. Dang, W. B. Dunn, F. Fernandez, et al. 2019. International ring trial of a high resolution targeted metabolomics and lipidomics platform for serum and plasma analysis. Analytical Chemistry 91 (22):14407–16. doi: 10.1021/acs.analchem.9b02908.
  • Thrane, M., P. V. Paulsen, M. W. Orcutt, and T. M. Krieger. 2017. Soy protein: Impacts, production, and applications. In Sustainable protein sources, eds. S. R. Nadathur, J. P. D. Wanasundara, and L. Scanlin. London: Academic Press. doi: 10.1016/B978-0-12-802778-3.00002-0.
  • Toaldo, I. M., J. Van Camp, G. B. Gonzales, S. Kamiloglu, M. T. Bordignon-Luiz, G. Smagghe, K. Raes, E. Capanoglu, and C. Grootaert. 2016. Resveratrol improves TNF-α-induced endothelial dysfunction in a coculture model of a Caco-2 with an endothelial cell line. The Journal of Nutritional Biochemistry 36:21–30. doi: 10.1016/j.jnutbio.2016.07.007.
  • Tomás-Navarro, M., F. Vallejo, and F. A. Tomás-Barberán. 2013. Bioavailability and metabolism of citrus fruit beverage flavanones in humans. Polyphenols in Human Health and Disease 1:537–51. doi: 10.1016/B978-0-12-398456-2.00040-2.
  • Tsakelidou, E., C. Virgiliou, L. Valianou, H. G. Gika, N. Raikos, and G. Theodoridis. 2017. Sample preparation strategies for the effective quantitation of hydrophilic metabolites in serum by multi-targeted HILIC-MS/MS. Metabolites 7 (2):13. doi: 10.3390/metabo7020013.
  • Vattem, D. A., and K. Shetty. 2006. Functional phytochemicals from cranberries: Their mechanism of action and strategies to improve functionality. Functional Foods and Biotechnology 37:151–86. doi: 10.1002/chin.200626259.
  • Viljoen, A. M., J. Zhao, M. Sandasi, W. Chen, and I. A. Khan. 2015. Phytochemical distinction between Pelargonium sidoides (“Umckaloabo”) and P. reniforme through 1H-NMR and UHPLC–MS metabolomic profiling. Metabolomics 11 (3):594–602. doi: 10.1007/s11306-014-0722-2.
  • Vinaixa, M., E. L. Schymanski, S. Neumann, M. Navarro, R. M. Salek, and O. Yanes. 2016. Mass spectral databases for LC/MS- and GC/MS-based metabolomics: State of the field and future prospects. TrAC Trends in Analytical Chemistry 78:23–35. doi: 10.1016/j.trac.2015.09.005.
  • Wallace, E. D., N. H. Oberlies, N. B. Cech, and J. J. Kellogg. 2018. Detection of adulteration in Hydrastis canadensis (goldenseal) dietary supplements via untargeted mass spectrometry-based metabolomics. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 120:439–47. doi: 10.1016/j.fct.2018.07.033.
  • Wallace, E. D., D. A. Todd, J. M. Harnly, N. B. Cech, and J. J. Kellogg. 2020. Identification of adulteration in botanical samples with untargeted metabolomics. Analytical and Bioanalytical Chemistry 412 (18):4273–86. doi: 10.1007/s00216-020-02678-6.
  • Weber, R. J. M., T. N. Lawson, R. M. Salek, T. M. D. Ebbels, R. C. Glen, R. Goodacre, J. L. Griffin, K. Haug, A. Koulman, P. Moreno, et al. 2017. Computational tools and workflows in metabolomics: An international survey highlights the opportunity for harmonisation through Galaxy. Metabolomics 13 (2):12. doi: 10.1007/s11306-016-1147-x.
  • Xiao, J. 2015. Phytochemicals in medicine and food. Phytochemistry Reviews 14 (3):317–20. doi: 10.1007/s11101-015-9407-3.
  • Xie, C., J. Kang, J. R. Chen, S. Nagarajan, T. M. Badger, and X. Wu. 2011. Phenolic acids are in vivo atheroprotective compounds appearing in the serum of rats after blueberry consumption. Journal of Agricultural and Food Chemistry 59 (18):10381–7. doi: 10.1021/jf2025264.
  • Xu, Y., Y. Li, K. G. Maffucci, L. Huang, and R. Zeng. 2017. Analytical methods of phytochemicals from the genus gentiana. Molecules 22 (12):2080. doi: 10.3390/molecules22122080.
  • Yang, C., X. Su, A. Liu, L. Zhang, A. Yu, Y. Xi, and G. Zhai. 2013. Advances in clinical study of curcumin. Current Pharmaceutical Design 19 (11):1966–73. doi: 10.2174/1381612811319110002.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.