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Review Articles

Neurodevelopmental effects of maternal folic acid supplementation: a systematic review and meta-analysis

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References

  • Alobaidi, R., C. Morgan, R. K. Basu, E. Stenson, R. Featherstone, S. R. Majumdar, and S. M. Bagshaw. 2018. Association between fluid balance and outcomes in critically ill children: A systematic review and meta-analysis. JAMA Pediatrics 172 (3):257–68. doi: 10.1001/jamapediatrics.2017.4540.
  • Chatzi, L., E. Papadopoulou, K. Koutra, T. Roumeliotaki, V. Georgiou, N. Stratakis, V. Lebentakou, M. Karachaliou, M. Vassilaki, and M. Kogevinas. 2012. Effect of high doses of folic acid supplementation in early pregnancy on child neurodevelopment at 18 months of age: The mother-child cohort ‘Rhea’ study in Crete, Greece. Public Health Nutrition 15 (9):1728–36. doi: 10.1017/s1368980012000067.
  • Chen, Q.,Huang, L-x.Xu, W-j.Chen, H.Zhong, J-q, andZeng, C-x. 2014. Research on the prevalence and the risk factors of autism spectrum disorder from 1.5 to 3 years old in Zhuhai city. Chinese Journal of Child Health Care 22(6):649–51. doi: 10.11852/zgetbjzz2014-22-06-28
  • Compañ Gabucio, L. M.,M. García De La Hera,L. Torres Collado,A. Fernández-Somoano,A. Tardón,M. Guxens,M. Vrijheid,M. Rebagliato,M. Murcia,J. Ibarluzea, et al. 2021. The Use of Lower or Higher Than Recommended Doses of Folic Acid Supplements during Pregnancy Is Associated with Child Attentional Dysfunction at 4–5 Years of Age in the INMA Project. Nutrients 13 (2):327 doi:10.3390/nu13020327.
  • Compañ Gabucio, L. M., M. García de la Hera, L. Torres Collado, A. Fernández-Somoano, A. Tardón, M. Guxens, M. Vrijheid, M. Rebagliato, M. Murcia, J. Ibarluzea, et al. 2021. The use of lower or higher than recommended doses of folic acid supplements during pregnancy is associated with child attentional dysfunction at 4–5 years of age in the inma project. Nutrients 13 (2):327–16. doi: 10.3390/nu13020327.
  • Craciunescu, C. N., E. C. Brown, M. H. Mar, C. D. Albright, M. R. Nadeau, and S. H. Zeisel. 2004. Folic acid deficiency during late gestation decreases progenitor cell proliferation and increases apoptosis in fetal mouse brain. The Journal of Nutrition 134 (1):162–6. doi: 10.1093/jn/134.1.162.
  • Curtin, M., D. Baker, A. Staines, and I. J. Perry. 2014. Are the special educational needs of children in their first year in primary school in Ireland being identified: A cross-sectional study. BMC Pediatrics 14:52 doi: 10.1186/1471-2431-14-52.
  • D’Souza, S.,K. E. Waldie,E. R. Peterson,L. Underwood, andS. M. B. Morton. 2019. Antenatal and Postnatal Determinants of Behavioural Difficulties in Early Childhood: Evidence from Growing Up in New Zealand. Child Psychiatry and Human Development 50 (1):45–60. doi:10.1007/s10578-018-0816-6. PMID: 29860616
  • D’Souza, S.,C. N. Crawford,J. Buckley,L. Underwood,E. R. Peterson,A. Bird,S. M. B. Morton, andK. E. Waldie. 2019. Antenatal determinants of early childhood talking delay and behavioural difficulties. Infant Behavior & Development 57:101388 doi:10.1016/j.infbeh.2019.101388. PMC: 31634704
  • Degroote, S., D. Hunting, and L. Takser. 2018. Periconceptional folate deficiency leads to autism-like traits in Wistar rat offspring. Neurotoxicology and Teratology 66:132–8. doi: 10.1016/j.ntt.2017.12.008.
  • Del Río Garcia, C.,L. Torres-Sánchez,J. Chen,L. Schnaas,C. Hernández,E. Osorio,M. G. Portillo, andL. López-Carrillo. 2009. Maternal MTHFR 677C>T genotype and dietary intake of folate and vitamin B 12 : their impact on child neurodevelopment. Nutritional Neuroscience 12 (1):13–20. doi:10.1179/147683009X388913.
  • Desoto, M. C., andR. T. Hitlan. 2012. Synthetic folic acid supplementation during pregnancy may increase the risk of developing autism. Journal of Pediatric Biochemistry 2 (4):251–61. doi: 10.3233/JPB-120066.
  • Desoto, M. C., and R. T. Hitlan. 2012. Synthetic folic acid supplementation during pregnancy may increase the risk of developing autism. Journal of Pediatric Biochemistry 2 (4):251–61. doi: 10.3233/JPB-120066.
  • DeVilbiss, E. A.,C. Magnusson,R. M. Gardner,D. Rai,C. J. Newschaffer,K. Lyall,C. Dalman, andB. K. Lee. 2017. Antenatal nutritional supplementation and autism spectrum disorders in the Stockholm youth cohort: population based cohort study. BMJ (Clinical Research Ed.) 359:j4273 doi:10.1136/bmj.j4273. PMC: 28978695
  • Di, Y., Z. Li, J. Li, Q. Cheng, Q. Zheng, C. Zhai, M. Kang, C. Wei, J. Lan, J. Fan, et al. 2021. Maternal folic acid supplementation prevents autistic behaviors in a rat model induced by prenatal exposure to valproic acid. Food & Function 12 (10):4544–55. doi: 10.1039/d0fo02926b.
  • Djukic, A. 2007. Folate-responsive neurologic diseases. Pediatric Neurology 37 (6):387–97. doi: 10.1016/j.pediatrneurol.2007.09.001.
  • Forns, J.,M. Torrent,R. Garcia-Esteban,A. Cáceres,M. Pilar Gomila,D. Martinez,E. Morales,J. Julvez,J. O. Grimalt, andJ. Sunyer. 2012. Longitudinal association between early life socio-environmental factors and attention function at the age 11 years. Environmental Research 117:54–9. doi:10.1016/j.envres.2012.04.007. PMID:22608140
  • Gao, Y., C. Sheng, R. H. Xie, W. Sun, E. Asztalos, D. Moddemann, L. Zwaigenbaum, M. Walker, and S. W. Wen. 2016. New perspective on impact of folic acid supplementation during pregnancy on neurodevelopment/autism in the offspring children - A systematic review. PLoS One 11 (11):e0165626 doi: 10.1371/journal.pone.0165626.
  • Handal, M.,S. Skurtveit,C. Roth,S. Hernandez-Diaz, andR. Selmer. 2016. Prenatal Exposure to Folic Acid and Antidepressants and Language Development: A Population-Based Cohort Study. Journal of Clinical Psychopharmacology 36 (4):333–9. doi:10.1097/JCP.0000000000000519. PMID: 27285658
  • Henry, L. A., T. Cassidy, M. McLaughlin, K. Pentieva, H. McNulty, C. P. Walsh, and D. Lees-Murdock. 2018. Folic Acid Supplementation throughout pregnancy: Psychological developmental benefits for children. Acta Paediatrica 107 (8):1370–8. doi: 10.1111/apa.14290.
  • Jeste, S. S. 2015. Neurodevelopmental behavioral and cognitive disorders. Continuum (Minneapolis, Minn.) 21 (3):690–714. doi: 10.1212/01.CON.0000466661.89908.3c.
  • Jiang, H.,L. Liu,D. L. Sun,X. N. Yin,Z. D. Chen,C. A. Wu, andW. Q. Chen. 2016. [Interaction between passive smoking and folic acid supplement during pregnancy on autism spectrum disorder behaviors in children aged 3 years]. Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi 37 (7):940–4. doi:10.3760/cma.j.issn.0254-6450.2016.07.007. PMID: 27453101
  • Julvez, J.,. J. Fortuny, M. Mendez, M. Torrent, N. Ribas-Fitó, and J. Sunyer. 2009. Maternal use of folic acid supplements during pregnancy and four-year-old neurodevelopment in a population-based birth cohort. Paediatric and Perinatal Epidemiology 23 (3):199–206. doi: 10.1111/j.1365-3016.2009.01032.x.
  • King, J. C. 2016. A summary of pathways or mechanisms linking preconception maternal nutrition with birth outcomes. The Journal of Nutrition 146 (7):1437S–44s. doi: 10.3945/jn.115.223479.
  • Levine, S. Z., A. Kodesh, A. Viktorin, L. Smith, R. Uher, A. Reichenberg, and S. Sandin. 2018. Association of maternal use of folic acid and multivitamin supplements in the periods before and during pregnancy with the risk of autism spectrum disorder in offspring. JAMA Psychiatry 75 (2):176–84. doi: 10.1001/jamapsychiatry.2017.4050.
  • Li, X.,Z. Y. Ling,J. M. Wang,S. P. Yang,Y. Y. Tan, andS. N. Xie. 2015. Periconceptional risk factors for childhood autism: a 1: 1 matched case-control study. Acta Med Univ Sci Technol Huazhong 44 (3):357–61.
  • Liew, S. C., and E. D. Gupta. 2015. Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: Epidemiology, metabolism and the associated diseases. European Journal of Medical Genetics 58 (1):1–10. doi: 10.1016/j.ejmg.2014.10.004.
  • Li, M., E. Francis, S. N. Hinkle, A. S. Ajjarapu, and C. Zhang. 2019. Preconception and prenatal nutrition and neurodevelopmental disorders: A systematic review and meta-analysis. Nutrients 11 (7)1628. doi: 10.3390/nu1107:.
  • Li, W., Z. Li, S. Li, X. Wang, J. X. Wilson, and G. Huang. 2018. Periconceptional folic acid supplementation benefit to development of early sensory-motor function through increase DNA methylation in rat offspring. Nutrients 10 (3):292. doi: 10.3390/nu10030292.
  • Liu, H. Y., S. M. Liu, and Y. Z. Zhang. 2020. Maternal folic acid supplementation mediates offspring health via DNA methylation. Reproductive Sciences (Thousand Oaks, Calif.) 27 (4):963–76. doi: 10.1007/s43032-020-00161-2.
  • McNulty, H., M. Rollins, T. Cassidy, A. Caffrey, B. Marshall, J. Dornan, M. McLaughlin, et al. 2019. Effect of continued folic acid supplementation beyond the first trimester of pregnancy on cognitive performance in the child: A follow-up study from a randomized controlled trial (FASSTT Offspring Trial). BMC Medicine 17 (1):196. doi: 10.1186/s12916-019-1432-4.
  • Miyake, Y.,K. Tanaka,H. Okubo,S. Sasaki, andM. Arakawa. 2020. Maternal B vitamin intake during pregnancy and childhood behavioral problems in Japan: The Kyushu Okinawa Maternal and Child Health Study. Nutritional Neuroscience 23 (9):706–13. doi:10.1080/1028415X.2018.1548139. PMID: 30453854
  • Moher, D., A. Liberati, J. Tetzlaff, and D. G. Altman. 2009. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. BMJ (Clinical Research ed.) 339:b2535 doi: 10.1136/bmj.b2535.
  • Mousa, A., A. Naqash, and S. Lim. 2019. Macronutrient and micronutrient intake during pregnancy: An overview of recent evidence. Nutrients 11 (2):443. doi: 10.3390/nu11020443.
  • Murray, L. K., M. J. Smith, and N. M. Jadavji. 2018. Maternal oversupplementation with folic acid and its impact on neurodevelopment of offspring. Nutrition Reviews 76 (9):708–21. doi: 10.1093/nutrit/nuy025.
  • Naninck, E. F. G., P. C. Stijger, and E. M. Brouwer-Brolsma. 2019. The importance of maternal folate status for brain development and function of offspring. Advances in Nutrition (Bethesda, Md.) 10 (3):502–19. doi: 10.1093/advances/nmy120.
  • Nilsen, R. M.,P. Surén,N. Gunnes,E. R. Alsaker,M. Bresnahan,D. Hirtz,M. Hornig,K. K. Lie,W. I. Lipkin,T. Reichborn-Kjennerud, et al. 2013. Analysis of Self-selection Bias in a Population-based Cohort Study of Autism Spectrum Disorders. Paediatric and Perinatal Epidemiology 27 (6):553–63. doi:10.1111/ppe.12077.
  • Polańska, K.,P. Muszyński,W. Sobala,E. Dziewirska,D. Merecz-Kot, andW. Hanke. 2015. Maternal lifestyle during pregnancy and child psychomotor development — Polish Mother and Child Cohort study. Early Human Development 91 (5):317–25. doi:10.1016/j.earlhumdev.2015.03.002.
  • Rice, D., and S. Barone. Jr. 2000. Critical periods of vulnerability for the developing nervous system: Evidence from humans and animal models. Environmental Health Perspectives 108 (Suppl 3):511–33. doi: 10.1289/ehp.00108s3511.
  • Roth, C.,P. Magnus,S. Schjølberg,C. Stoltenberg,P. Surén,I. W. McKeague,G. Davey Smith,T. Reichborn-Kjennerud, andE. Susser. 2011. Folic acid supplements in pregnancy and severe language delay in children. JAMA 306 (14):1566–73. doi:10.1001/jama.2011.1433. PMID: 21990300
  • Roza, S. J.,T. Van Batenburg-Eddes,E. A. P. Steegers,V. W. V. Jaddoe,J. P. Mackenbach,A. Hofman,F. C. Verhulst, andH. Tiemeier. 2010. Maternal folic acid supplement use in early pregnancy and child behavioural problems: The Generation R Study. The British Journal of Nutrition 103 (3):445–52. doi:10.1017/S0007114509991954. PMID: 19772683
  • Sahay, A., A. Kale, and S. Joshi. 2020. Role of neurotrophins in pregnancy and offspring brain development. Neuropeptides 83:102075 doi: 10.1016/j.npep.2020.102075.
  • Schlotz, W.,A. Jones,D. I. W. Phillips,C. R. Gale,S. M. Robinson, andK. M. Godfrey. 2010. Lower maternal folate status in early pregnancy is associated with childhood hyperactivity and peer problems in offspring. Journal of Child Psychology and Psychiatry, and Allied Disciplines 51 (5):594–602. doi:10.1111/j.1469-7610.2009.02182.x. PMID: 19874428
  • Schmidt, R. J.,A.-M. Iosif,E. Guerrero Angel, andS. Ozonoff. 2019. Association of Maternal Prenatal Vitamin Use With Risk for Autism Spectrum Disorder Recurrence in Young Siblings. JAMA Psychiatry 76 (4):391–8. doi:10.1001/jamapsychiatry.2018.3901. PMID: 30810722
  • Schmidt, R. J., D. J. Tancredi, S. Ozonoff, R. L. Hansen, J. Hartiala, H. Allayee, L. C. Schmidt, F. Tassone, and I. Hertz-Picciotto. 2012. Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study. The American Journal of Clinical Nutrition 96 (1):80–9. doi: 10.3945/ajcn.110.004416.
  • Sharman Moser, S.,. M. Davidovitch, R. S. Rotem, G. Chodick, V. Shalev, and G. Koren. 2019. High dose folic acid during pregnancy and the risk of autism; the birth order bias: A nested case-control study. Reproductive Toxicology 89:173–7. doi: 10.1016/j.reprotox.2019.07.083.
  • Steenweg-De Graaff, J.,S. J. Roza,E. A. Steegers,A. Hofman,F. C. Verhulst,V. W. Jaddoe, andH. Tiemeier. 2012. Maternal folate status in early pregnancy and child emotional and behavioral problems: the Generation R Study. The American Journal of Clinical Nutrition 95 (6):1413–21. doi:10.3945/ajcn.111.030791. PMID: 22572645
  • Steenweg-De Graaff, J.,A. Ghassabian,V. W. V. Jaddoe,H. Tiemeier, andS. J. Roza. 2015. Folate concentrations during pregnancy and autistic traits in the offspring. The Generation R Study. European Journal of Public Health 25 (3):431–3. doi:10.1093/eurpub/cku126. PMID: 25085472
  • Steenweg-de Graaff, J., A. Ghassabian, V. W. Jaddoe, H. Tiemeier, and S. J. Roza. 2015. Folate concentrations during pregnancy and autistic traits in the offspring. The Generation R Study. European Journal of Public Health 25 (3):431–3. doi: 10.1093/eurpub/cku126.
  • Strøm, M.,C. Granström,K. Lyall,A. Ascherio, andS. F. Olsen. 2018. Research Letter: Folic acid supplementation and intake of folate in pregnancy in relation to offspring risk of autism spectrum disorder. Psychological Medicine 48 (6):1048–54. doi:10.1017/S0033291717002410. PMID: 28946926
  • Sun, Y.,T. Shao,Y. Yao,H. Tao,L. Ni,S. Yan,C. Gu,H. Cao,K. Huang, andF. Tao. 2016. [Pregnancy-related anxiety and subthreshold autism trait in preschool children based a birth cohort study]. Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine] 50 (2):118–22. doi:10.3760/cma.j.issn.0253-9624.2016.02.004. PMID: 26926718
  • Surén, P.,C. Roth,M. Bresnahan,M. Haugen,M. Hornig,D. Hirtz,K. K. Lie,W. I. Lipkin,P. Magnus,T. Reichborn-Kjennerud, et al. 2013. Association between maternal use of folic acid supplements and risk of autism spectrum disorders in children. JAMA 309 (6):570–7. doi:10.1001/jama.2012.155925. PMID: 23403681
  • Tan, M.,T. Yang,J. Zhu,Q. Li,X. Lai,Y. Li,T. Tang,J. Chen, andT. Li. 2020. Maternal folic acid and micronutrient supplementation is associated with vitamin levels and symptoms in children with autism spectrum disorders. Reproductive Toxicology 91:109–15. doi:10.1016/j.reprotox.2019.11.009.
  • Tau, G. Z., and B. S. Peterson. 2010. Normal development of brain circuits. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 35 (1):147–68. doi: 10.1038/npp.2009.115.
  • Thekra N, A-m.,A.-O. Nourah M,A.-M. Latifa S, andA.-D. Danah M. 2021. Prenatal Factors Influencing the Risk of Autism Spectrum Disorder. ADVANCES in NEURODEVELOPMENTAL DISORDERS 5 (1):71–6.doi: 10.1007/s41252-020-00178-3.
  • Valera-Gran, D.,E. M. Navarrete-Muñoz,M. Garcia De La Hera,A. Fernández-Somoano,A. Tardón,J. Ibarluzea,N. Balluerka,M. Murcia,L. González-Safont,D. Romaguera, et al. 2017. Effect of maternal high dosages of folic acid supplements on neurocognitive development in children at 4-5 y of age: the prospective birth cohort Infancia y Medio Ambiente (INMA) study. The American Journal of Clinical Nutrition 106 (3):878–87. doi:10.3945/ajcn.117.152769. PMID: 28724645
  • Valera-Gran, D.,M. García De La Hera,E. M. Navarrete-Muñoz,A. Fernandez-Somoano,A. Tardón,J. Julvez,J. Forns,N. Lertxundi,J. M. Ibarluzea,M. Murcia, et al. 2014. Folic Acid Supplements During Pregnancy and Child Psychomotor Development After the First Year of Life. JAMA Pediatrics 168 (11):e142611 doi:10.1001/jamapediatrics.2014.2611.
  • Valera-Gran, D., M. García de la Hera, E. M. Navarrete-Muñoz, A. Fernandez-Somoano, A. Tardón, J. Julvez, J. Forns, N. Lertxundi, J. M. Ibarluzea, M. Murcia, et al. 2014. Folic acid supplements during pregnancy and child psychomotor development after the first year of life. JAMA Pediatrics 168 (11):e142611. doi: 10.1001/jamapediatrics.2014.2611.
  • Valera-Gran, D., E. M. Navarrete-Muñoz, M. Garcia de la Hera, A. Fernández-Somoano, A. Tardón, J. Ibarluzea, N. Balluerka, M. Murcia, L. González-Safont, D. Romaguera, et al. 2017. Effect of maternal high dosages of folic acid supplements on neurocognitive development in children at 4-5 y of age: The prospective birth cohort Infancia y Medio Ambiente (INMA) study. The American Journal of Clinical Nutrition 106 (3):878–87. doi: 10.3945/ajcn.117.152769.
  • Villamor, E.,S. L. Rifas-Shiman,M. W. Gillman, andE. Oken. 2012. Maternal intake of methyl-donor nutrients and child cognition at 3 years of age. Paediatric and Perinatal Epidemiology 26 (4):328–35. doi:10.1111/j.1365-3016.2012.01264.x. PMID: 22686384
  • Vinaykumar, N., A. Kumar, L. S. Quadros, and L. C. Prasanna. 2019. Determining the effect of folate diets during pregnancy and lactation on neurobehavioural changes in the adult life of offspring. Journal of Taibah University Medical Sciences 14 (6):523–30. doi: 10.1016/j.jtumed.2019.09.009.
  • Virk, J.,Z. Liew,J. Olsen,E. A. Nohr,J. M. Catov, andB. Ritz. 2018. Pre-conceptual and prenatal supplementary folic acid and multivitamin intake, behavioral problems, and hyperkinetic disorders: A study based on the Danish National Birth Cohort (DNBC). Nutritional Neuroscience 21 (5):352–60. doi:10.1080/1028415X.2017.1290932. PMID: 28276257
  • Virk, J.,Z. Liew,J. Olsen,E. A. Nohr,J. M. Catov, andB. Ritz. 2016. Preconceptional and prenatal supplementary folic acid and multivitamin intake and autism spectrum disorders. Autism : The International Journal of Research and Practice 20 (6):710–8. doi:10.1177/1362361315604076. PMID: 26408631
  • Vohr, B. R., E. Poggi Davis, C. A. Wanke, and N. F. Krebs. 2017. Neurodevelopment: The impact of nutrition and inflammation during preconception and pregnancy in low-resource settings. Pediatrics 139 (Suppl 1):S38–s49. doi: 10.1542/peds.2016-2828F.
  • Wang, X., W. Li, S. Li, J. Yan, J. X. Wilson, and G. Huang. 2018. Maternal folic acid supplementation during pregnancy improves neurobehavioral development in rat offspring. Molecular Neurobiology 55 (3):2676–84. doi: 10.1007/s12035-017-0534-2.
  • Wang, M., K. Li, D. Zhao, and L. Li. 2017. The association between maternal use of folic acid supplements during pregnancy and risk of autism spectrum disorders in children: A meta-analysis. Molecular Autism 8:51 doi: 10.1186/s13229-017-0170-8.
  • Wang, X., Z. Li, Y. Zhu, J. Yan, H. Liu, G. Huang, and W. Li. 2021. Maternal folic acid impacts DNA methylation profile in male rat offspring implicated in neurodevelopment and learning/memory abilities. Genes & Nutrition 16 (1):1. doi: 10.1186/s12263-020-00681-1.
  • Wehby, G. L., andJ. C. Murray. 2008. The effects of prenatal use of folic acid and other dietary supplements on early child development. Maternal and Child Health Journal 12 (2):180–7. doi:10.1007/s10995-007-0230-3. PMID: 17554612
  • Wells, G. A., B. Shea, D. O’Connell, J. Peterson, V. Welch, M. Losos, and P. Tugwell. 2021. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Available from: URL: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp
  • Yan, J.,Y. Zhu,L.-J. Cao,Y.-Y. Liu,Y.-Z. Zheng,W. Li, andG.-W. Huang. 2020. Effects of maternal folic acid supplementation during pregnancy on infant neurodevelopment at 1 month of age: a birth cohort study in China. European Journal of Nutrition 59 (4):1345–56. doi:10.1007/s00394-019-01986-7.

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