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Targeting long non coding RNA by natural products: Implications for cancer therapy

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  • Abdulridha, M. K., A.-H. Al-Marzoqi, G. R. L. Al-Awsi, S. M. Mubarak, M. Heydarifard, and A. Ghasemian, 2020. Anticancer Effects of Herbal Medicine Compounds and Novel Formulations: a Literature Review. Journal of Gastrointestinal Cancer 51 (3):765–73. doi: 10.1007/s12029-020-00385-0. PMID: 32140897
  • Abedini, P., A. Fattahi, S. Agah, A. Talebi, A. H. Beygi, S. M. Amini, A. Mirzaei, and A. Akbari. 2019. Expression analysis of circulating plasma long noncoding RNAs in colorectal cancer: The relevance of lncRNAs ATB and CCAT1 as potential clinical hallmarks. Journal of Cellular Physiology 234 (12):22028–33. doi: 10.1002/jcp.28765.
  • Al Aameri, R. F. H., S. Sheth, E. M. A. Alanisi, V. Borse, D. Mukherjea, L. P. Rybak, and V. Ramkumar. 2017. Tonic suppression of PCAT29 by the IL-6 signaling pathway in prostate cancer: Reversal by resveratrol. PLoS One 12 (5):e0177198. doi: 10.1371/journal.pone.0177198.
  • Amare, D. E. 2020. Anti-cancer and other biological effects of a dietary compound 3, 3′-diindolylmethane supplementation: A systematic review of human clinical trials. Nutrition and Dietary Supplements 12:123–37. doi: 10.2147/NDS.S261577.
  • Ashrafizadeh, M., M. Najafi, P. Makvandi, A. Zarrabi, T. Farkhondeh, and S. Samarghandian. 2020. Versatile role of curcumin and its derivatives in lung cancer therapy. Journal of Cellular Physiology 235 (12):9241–68. doi: 10.1002/jcp.29819.
  • Awasthee, N., V. Rai, S. S. Verma, K. S. Francis, M. S. Nair, and S. C. Gupta. 2018. Anti-cancer activities of Bharangin against breast cancer: Evidence for the role of NF-κB and lncRNAs. Biochimica et Biophysica Acta. General Subjects 1862 (12):2738–49. doi: 10.1016/j.bbagen.2018.08.016.
  • Azam, S., S. Hou, B. Zhu, W. Wang, T. Hao, X. Bu, M. Khan, and H. Lei. 2019. Nuclear retention element recruits U1 snRNP components to restrain spliced lncRNAs in the nucleus. RNA Biology 16 (8):1001–9. doi: 10.1080/15476286.2019.1620061.
  • Bai, L., A. Wang, Y. Zhang, X. Xu, and X. Zhang. 2018. Knockdown of MALAT1 enhances chemosensitivity of ovarian cancer cells to cisplatin through inhibiting the Notch1 signaling pathway. Experimental Cell Research 366 (2):161–71. doi: 10.1016/j.yexcr.2018.03.014.
  • Bao, X., T. Ren, Y. Huang, K. Sun, S. Wang, K. Liu, B. Zheng, and W. Guo. 2017. Knockdown of long non-coding RNA HOTAIR increases miR-454-3p by targeting Stat3 and Atg12 to inhibit chondrosarcoma growth. Cell Death & Disease 8 (2):e2605. doi: 10.1038/cddis.2017.31.
  • Beaver, L. M., R. Kuintzle, A. Buchanan, M. W. Wiley, S. T. Glasser, C. P. Wong, G. S. Johnson, J. H. Chang, C. V. Löhr, D. E. Williams, et al. 2017. Long noncoding RNAs and sulforaphane: A target for chemoprevention and suppression of prostate cancer. The Journal of Nutritional Biochemistry 42:72–83. doi: 10.1016/j.jnutbio.2017.01.001.
  • Bishayee, A. 2009. Cancer prevention and treatment with resveratrol: From rodent studies to clinical trials. Cancer Prevention Research (Philadelphia, Pa.) 2 (5):409–18. doi: 10.1158/1940-6207.CAPR-08-0160.
  • Bishayee, A., and G. Sethi. 2016. Bioactive natural products in cancer prevention and therapy: Progress and promise. Seminars in Cancer Biology 40–41:1–3. doi: 10.1016/j.semcancer.2016.08.006.
  • Blackadar, C. B. 2016. Historical review of the causes of cancer. World Journal of Clinical Oncology 7 (1):54–86. doi: 10.5306/wjco.v7.i1.54.
  • Boots, A. W., G. R. Haenen, and A. Bast. 2008. Health effects of quercetin: From antioxidant to nutraceutical. European Journal of Pharmacology 585 (2–3):325–37. doi: 10.1016/j.ejphar.2008.03.008.
  • Borriello, A., D. Bencivenga, I. Caldarelli, A. Tramontano, A. Borgia, V. Zappia, et al. 2014. Resveratrol: From basic studies to bedside. Advances in Nutrition and Cancer 159:167–84. doi: 10.1007/978-3-642-38007-5_10.
  • Cabili, M. N., M. C. Dunagin, P. D. McClanahan, A. Biaesch, O. Padovan-Merhar, A. Regev, J. L. Rinn, and A. Raj. 2015. Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution. Genome Biology 16 (1):20. doi: 10.1186/s13059-015-0586-4.
  • Cai, H., J. Chen, B. He, Q. Li, Y. Li, and Y. Gao. 2015. A FOXM1 related long non-coding RNA contributes to gastric cancer cell migration. Molecular and Cellular Biochemistry 406 (1–2):31–41. doi: 10.1007/s11010-015-2421-3.
  • Cai, J., H. Sun, B. Zheng, M. Xie, C. Xu, G. Zhang, X. Huang, and J. Zhuang. 2020. Curcumin attenuates lncRNA H19-induced epithelial-mesenchymal transition in tamoxifen-resistant breast cancer cells. Molecular Medicine Reports 23 (1):1. doi: 10.3892/mmr.2020.11651.
  • Cai, Q., L. Jin, S. Wang, D. Zhou, J. Wang, Z. Tang, and Z. Quan. 2017. Long non-coding RNA UCA1 promotes gallbladder cancer progression by epigenetically repressing p21 and E-cadherin expression. Oncotarget 8 (29):47957–68. doi: 10.18632/oncotarget.18204.
  • Carlevaro-Fita, J., A. Rahim, R. Guigó, L. A. Vardy, and R. Johnson. 2016. Cytoplasmic long noncoding RNAs are frequently bound to and degraded at ribosomes in human cells. RNA (New York, NY) 22 (6):867–82. doi: 10.1261/rna.053561.115.
  • Carullo, G., A. R. Cappello, L. Frattaruolo, M. Badolato, B. Armentano, and F. Aiello. 2017. Quercetin and derivatives: Useful tools in inflammation and pain management. Future Medicinal Chemistry 9 (1):79–93. doi: 10.4155/fmc-2016-0186.
  • Chai, R., C. Xu, L. Lu, X. Liu, and Z. Ma. 2021. Quercetin inhibits proliferation of and induces apoptosis in non-small-cell lung carcinoma via the lncRNA SNHG7/miR-34a-5p pathway. Immunopharmacology and Immunotoxicology:1–11. doi: 10.1080/08923973.2021.1966032.
  • Chang, L., R. Guo, Z. Yuan, H. Shi, and D. Zhang. 2018. LncRNA HOTAIR regulates CCND1 and CCND2 expression by sponging miR-206 in ovarian cancer. Cell Physiology and Biochemistry 49 (4):1289–303. doi: 10.1159/000493408.
  • Chang, Z., J. Cui, and Y. Song. 2018. Long noncoding RNA PVT1 promotes EMT via mediating microRNA-186 targeting of Twist1 in prostate cancer. Gene 654:36–42. doi: 10.1016/j.gene.2018.02.036.
  • Chen, A., P. Jiang, F. Zeb, X. Wu, C. Xu, L. Chen, and Q. Feng. 2020. EGCG regulates CTR1 expression through its pro-oxidative property in non-small-cell lung cancer cells. Journal of Cellular Physiology 235 (11):7970–81. doi: 10.1002/jcp.29451.
  • Chen, C., K. Wang, Q. Wang, and X. Wang. 2018. LncRNA HULC mediates radioresistance via autophagy in prostate cancer cells. Brazilian Journal of Medical and Biological Research 51 (6):1–9. doi: 10.1590/1414-431x20187080.
  • Chen, J., C. Lin, W. Yong, Y. Ye, and Z. Huang. 2015. Calycosin and genistein induce apoptosis by inactivation of HOTAIR/p-Akt signaling pathway in human breast cancer MCF-7 cells. Cellular Physiology and Biochemistry : international Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology 35 (2):722–8. doi: 10.1159/000369732.
  • Chen, L., N. Hu, C. Wang, H. Zhao, and Y. Gu. 2018. Long non-coding RNA CCAT1 promotes multiple myeloma progression by acting as a molecular sponge of miR-181a-5p to modulate HOXA1 expression. Cell Cycle (Georgetown, Tex.) 17 (3):319–29. doi: 10.1080/15384101.2017.1407893.
  • Chen, L., W. Wang, L. Cao, Z. Li, and X. Wang. 2016. Long non-coding RNA CCAT1 acts as a competing endogenous RNA to regulate cell growth and differentiation in acute myeloid leukemia. Molecules and Cells 39 (4):330–6.
  • Chen, Q., J. Cai, Q. Wang, Y. Wang, M. Liu, J. Yang, J. Zhou, C. Kang, M. Li, and C. Jiang. 2018. Long noncoding RNA NEAT1, regulated by the EGFR pathway, contributes to glioblastoma progression through the WNT/β-catenin pathway by scaffolding EZH2. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 24 (3):684–95. doi: 10.1158/1078-0432.CCR-17-0605.
  • Chen, S., H. Ye, F. Gong, S. Mao, C. Li, B. Xu, Y. Ren, and R. Yu. 2021. Ginsenoside compound K exerts antitumour effects in renal cell carcinoma via regulation of ROS and lncRNA THOR. Oncology Reports 45 (4):1–13. doi: 10.3892/or.2021.7989.
  • Chen, T., P. Yang, H. Wang, and Z.-Y. He. 2017. Silence of long noncoding RNA PANDAR switches low-dose curcumin-induced senescence to apoptosis in colorectal cancer cells. OncoTargets and Therapy 10:483–91. doi: 10.2147/OTT.S127547.
  • Chen, W.-D., and X.-F. Zhu. 2013. Small nucleolar RNAs (snoRNAs) as potential non-invasive biomarkers for early cancer detection. Chinese Journal of Cancer 32 (2):99–101. doi: 10.5732/cjc.012.10132.
  • Chen, W.-W., Y.-F. Huang, Z.-B. Hu, Y.-M. Liu, H.-X. Xiao, D.-B. Liu, and Y.-Z. Zhuang. 2019. Microarray analysis of altered long non-coding RNA expression profile in liver cancer cells treated by ginsenoside Rh2. Journal of Asian Natural Products Research 21 (8):742–753. doi: 10.1080/10286020.2018.1490273.
  • Chen, X., S. Fan, and E. Song. 2016. The long and short non-coding RNAs in cancer biology. In Advances in Experimental Medicine and Biology, ed. E. Song, 927:1–47. Singapore: Springer. doi: 10.1007/978-981-10-1498-7_1.
  • Chen, X., Y. Wu, J. Gu, P. Liang, M. Shen, J. Xi, and J. Qin. 2020. Anti-invasive effect and pharmacological mechanism of genistein against colorectal cancer. BioFactors (Oxford, England) 46 (4):620–8. doi: 10.1002/biof.1627.
  • Chen, Y., H. Xu, C. Liu, M. Gu, M. Zhan, Q. Chen, and Z. Wang. 2021. LncRNA DIO3OS regulated by TGF-β1 and resveratrol enhances epithelial mesenchymal transition of benign prostatic hyperplasia epithelial cells and proliferation of prostate stromal cells. Translational Andrology and Urology 10 (2):643–653. doi: 10.21037/tau-20-1169.
  • Chen, Y., W. Huang, W. Sun, B. Zheng, C. Wang, Z. Luo, J. Wang, and W. Yan. 2018. LncRNA MALAT1 promotes cancer metastasis in osteosarcoma via activation of the PI3K-Akt signaling pathway. Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology 51 (3):1313–26. doi: 10.1159/000495550.
  • Chen, Z., X. Hu, Y. Wu, L. Cong, X. He, J. Lu, J. Feng, and D. Liu. 2019. Long non-coding RNA XIST promotes the development of esophageal cancer by sponging miR-494 to regulate CDK6 expression. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 109:2228–36. doi: 10.1016/j.biopha.2018.11.049.
  • Chi, Y., D. Wang, J. Wang, W. Yu, and J. Yang. 2019. Long non-coding RNA in the pathogenesis of cancers. Cells 8 (9):1015. doi: 10.3390/cells8091015.
  • Chin, D., P. Huebbe, J. Frank, G. Rimbach, and K. Pallauf. 2014. Curcumin may impair iron status when fed to mice for six months. Redox Biology 2:563–9. doi: 10.1016/j.redox.2014.01.018.
  • Chiyomaru, T., S. Fukuhara, S. Saini, S. Majid, G. Deng, V. Shahryari, I. Chang, Y. Tanaka, H. Enokida, M. Nakagawa, et al. 2014. Long non-coding RNA HOTAIR is targeted and regulated by miR-141 in human cancer cells. The Journal of Biological Chemistry 289 (18):12550–65. doi: 10.1074/jbc.M113.488593.
  • Chiyomaru, T., S. Yamamura, S. Fukuhara, H. Yoshino, T. Kinoshita, S. Majid, S. Saini, I. Chang, Y. Tanaka, H. Enokida, et al. 2013. Genistein inhibits prostate cancer cell growth by targeting miR-34a and oncogenic HOTAIR. PloS One 8 (8):e70372. doi: 10.1371/journal.pone.0070372.
  • Chu, P., L. Xu, and H. Su. 2019. HULC functions as an oncogene in ovarian carcinoma cells by negatively modulating miR-125a-3p. Journal of Physiology and Biochemistry 75 (2):163–71. doi: 10.1007/s13105-019-00669-5.
  • Cimino, S., G. Sortino, V. Favilla, T. Castelli, M. Madonia, S. Sansalone, G. I. Russo, and G. Morgia. 2012. Polyphenols: Key issues involved in chemoprevention of prostate cancer. Oxidative Medicine and Cellular Longevity 2012:632959. doi: 10.1155/2012/632959.
  • Collado, M., M. A. Blasco, and M. Serrano. 2007. Cellular senescence in cancer and aging. Cell 130 (2):223–33. doi: 10.1016/j.cell.2007.07.003.
  • Dahariya, S., I. Paddibhatla, S. Kumar, S. Raghuwanshi, A. Pallepati, and R. K. Gutti. 2019. Long non-coding RNA: Classification, biogenesis and functions in blood cells. Molecular Immunology 112:82–92. doi: 10.1016/j.molimm.2019.04.011.
  • Dai, W., L. Mu, Y. Cui, Y. Li, P. Chen, H. Xie, and X. Wang. 2019. Berberine promotes apoptosis of colorectal cancer via regulation of the long non-coding RNA (lncRNA) cancer susceptibility candidate 2 (CASC2)/AU-binding factor 1 (AUF1)/B-cell CLL/lymphoma 2 (Bcl-2) axis. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research 25:730–8. doi: 10.12659/MSM.912082.
  • Dai, W., L. Mu, Y. Cui, Y. Li, P. Chen, H. Xie, and X. Wang. 2019. Long non‑coding RNA CASC2 enhances berberine‑induced ­cytotoxicity in colorectal cancer cells by silencing BCL2. Molecular Medicine Reports 20 (2):995–1006. doi: 10.3892/mmr.2019.10326.
  • Dan, J., J. Wang, Y. Wang, M. Zhu, X. Yang, Z. Peng, H. Jiang, and L. Chen. 2018. LncRNA-MEG3 inhibits proliferation and metastasis by regulating miRNA-21 in gastric cancer. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 99:931–8. doi: 10.1016/j.biopha.2018.01.164.
  • de Araujo, J. T. C., M. Martin-Pastor, L. Pérez, A. Pinazo, and F. F. O. de Sousa. 2021. Development of anacardic acid-loaded zein nanoparticles: Physical chemical characterization, stability and antimicrobial improvement. Journal of Molecular Liquids 332:115808. doi: 10.1016/j.molliq.2021.115808.
  • Deng, M., H. Chen, J. Long, J. Song, L. Xie, and X. Li. 2021. Calycosin: A review of its pharmacological effects and application prospects. Expert Review of anti-Infective Therapy 19 (7):911–25. doi: 10.1080/14787210.2021.1863145.
  • Ding, N., H. Wu, T. Tao, and E. Peng. 2017. NEAT1 regulates cell proliferation and apoptosis of ovarian cancer by miR-34a-5p/BCL2. OncoTargets and Therapy 10:4905–15. doi: 10.2147/OTT.S142446.
  • Dong, S., X. Zhang, and D. Liu. 2019. Overexpression of long noncoding RNA GAS5 suppresses tumorigenesis and development of gastric cancer by sponging miR-106a-5p through the Akt/mTOR pathway. Biology Open 8 (6):bio041343.
  • Dong, Y., M.-H. Wei, J.-G. Lu, and C.-Y. Bi. 2019. Long non-coding RNA HULC interacts with miR-613 to regulate colon cancer growth and metastasis through targeting RTKN. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 109:2035–42. doi: 10.1016/j.biopha.2018.08.017.
  • Du, P., C. Hu, Y. Qin, J. Zhao, R. Patel, Y. Fu, M. Zhu, W. Zhang, and G. Huang. 2019. LncRNA PVT1 mediates antiapoptosis and 5-fluorouracil resistance via increasing Bcl2 expression in gastric cancer. Journal of Oncology 2019:9325407. doi: 10.1155/2019/9325407.
  • Du, Q.-H., C. Peng, and H. Zhang. 2013. Polydatin: A review of pharmacology and pharmacokinetics. Pharmaceutical Biology 51 (11):1347–54. doi: 10.3109/13880209.2013.792849.
  • Ersoy, E., E. E. Ozkan, M. Boga, and A. Mat. 2020. Evaluation of in vitro biological activities of three Hypericum species (H. calycinum, H. confertum, and H. perforatum) from Turkey. South African Journal of Botany 130:141–7. doi: 10.1016/j.sajb.2019.12.017.
  • Esmatabadi, M. J. D., M. Motamedrad, and M. Sadeghizadeh. 2018. Down-regulation of lncRNA, GAS5 decreases chemotherapeutic effect of dendrosomal curcumin (DNC) in breast cancer cells. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 42:56–65. doi: 10.1016/j.phymed.2018.03.022.
  • Esteghlal, S., M. J. Mokhtari, and Z. Beyzaei. 2021. Quercetin can inhibit angiogenesis via the down regulation of MALAT1 and MIAT LncRNAs in human umbilical vein endothelial cells. International Journal of Preventive Medicine 12 (1):59.
  • Ezzati, M., B. Yousefi, K. Velaei, and A. Safa. 2020. A review on anti-cancer properties of Quercetin in breast cancer. Life Sciences 248:117463. doi: 10.1016/j.lfs.2020.117463.
  • Fotouhi Ghiam, A., S. Taeb, X. Huang, V. Huang, J. Ray, S. Scarcello, C. Hoey, S. Jahangiri, E. Fokas, A. Loblaw, et al. 2017. Long non-coding RNA urothelial carcinoma associated 1 (UCA1) mediates radiation response in prostate cancer. Oncotarget 8 (3):4668–89. doi: 10.18632/oncotarget.13576.
  • Gao, Y., S. A. Snyder, J. N. Smith, and Y. C. Chen. 2016. Anticancer properties of baicalein: A review. Medicinal Chemistry Research: An International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents 25 (8):1515–23. doi: 10.1007/s00044-016-1607-x.
  • Gao, Z., K. Huang, and H. Xu. 2001. Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cells. Pharmacological Research 43 (2):173–8. doi: 10.1006/phrs.2000.0761.
  • Garitano-Trojaola, A., E. S. José-Enériz, T. Ezponda, J. P. Unfried, A. Carrasco-León, N. Razquin, M. Barriocanal, A. Vilas-Zornoza, B. Sangro, V. Segura, et al. 2018. Deregulation of linc-PINT in acute lymphoblastic leukemia is implicated in abnormal proliferation of leukemic cells. Oncotarget 9 (16):12842–52. doi: 10.18632/oncotarget.24401.
  • Geng, W., X. Guo, L. Zhang, Y. Ma, L. Wang, Z. Liu, H. Ji, and Y. Xiong. 2018. Resveratrol inhibits proliferation, migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 107:484–94. doi: 10.1016/j.biopha.2018.08.003.
  • Grynkiewicz, G., and P. Ślifirski. 2012. Curcumin and curcuminoids in quest for medicinal status. Acta Biochimica Polonica 59 (2):201–12. doi: 10.18388/abp.2012_2139.
  • Guo, X., and Y. Hua. 2017. CCAT1: An oncogenic long noncoding RNA in human cancers. Journal of Cancer Research and Clinical Oncology 143 (4):555–62. doi: 10.1007/s00432-016-2268-3.
  • Guo, X., H. Xiao, S. Guo, J. Li, Y. Wang, J. Chen, and G. Lou. 2019. Long noncoding RNA HOTAIR knockdown inhibits autophagy and epithelial-mesenchymal transition through the Wnt signaling pathway in radioresistant human cervical cancer HeLa cells. Journal of Cellular Physiology 234 (4):3478–89. doi: 10.1002/jcp.26828.
  • Gupta, S. C., R. Kannappan, J. Kim, G. M. Rahman, S. K. Francis, R. Raveendran, M. S. Nair, J. Das, and B. B. Aggarwal. 2011. Bharangin, a diterpenoid quinonemethide, abolishes constitutive and inducible nuclear factor-κB (NF-κB) activation by modifying p65 on cysteine 38 residue and reducing inhibitor of nuclear factor-κB α kinase activation, leading to suppression of NF-κB-regulated gene expression and sensitization of tumor cells to chemotherapeutic agents. Molecular Pharmacology 80 (5):769–81. doi: 10.1124/mol.111.073122.
  • Guttman, M., and J. L. Rinn. 2012. Modular regulatory principles of large non-coding RNAs. Nature 482 (7385):339–46. doi: 10.1038/nature10887.
  • Habtemariam, S. 2020. Berberine pharmacology and the gut microbiota: A hidden therapeutic link. Pharmacological Research 155:104722. doi: 10.1016/j.phrs.2020.104722.
  • Ham, J., D. Jeong, S. Park, H. W. Kim, H. Kim, and S. J. Kim. 2019. Ginsenoside Rg3 and Korean Red Ginseng extract epigenetically regulate the tumor-related long noncoding RNAs RFX3-AS1 and STXBP5-AS1. Journal of Ginseng Research 43 (4):625–34. doi: 10.1016/j.jgr.2019.02.004.
  • Han, Z., J. He, M. Zou, W. Chen, Y. Lv, and Y. Li. 2020. Small interfering RNA target for long noncoding RNA PCGEM1 increases the sensitivity of LNCaP cells to baicalein. Anatomical Record (Hoboken, NJ: 2007) 303 (8):2077–85. doi: 10.1002/ar.24454.
  • Harada, G., S. Onoue, C. Inoue, S. Hanada, and Y. Katakura. 2018. Delphinidin-3-glucoside suppresses lipid accumulation in HepG2 cells. Cytotechnology 70 (6):1707–12. doi: 10.1007/s10616-018-0246-0.
  • Harrow, J., A. Frankish, J. M. Gonzalez, E. Tapanari, M. Diekhans, F. Kokocinski, B. L. Aken, D. Barrell, A. Zadissa, S. Searle, et al. 2012. GENCODE: The reference human genome annotation for The ENCODE Project. Genome Research 22 (9):1760–74. doi: 10.1101/gr.135350.111.
  • Hasanpourghadi, M., C. Yeng Looi, A. Kumar Pandurangan, G. Sethi, W. Fen Wong, and M. Rais Mustafa. 2017. Phytometabolites targeting the Warburg effect in cancer cells: A mechanistic review. Current Drug Targets 18 (9):1086–94. doi: 10.2174/1389450117666160401124842.
  • Hassan, N. K. N. C., M. Taher, and D. Susanti. 2018. Phytochemical constituents and pharmacological properties of Garcinia xanthochymus- a review. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 106:1378–89. doi: 10.1016/j.biopha.2018.07.087.
  • Hertog, M., and P. Hollman. 1996. Potential health effects of the dietary flavonol quercetin. European Journal of Clinical Nutrition. 50 (2):63–71.
  • Hirata, H., Y. Hinoda, V. Shahryari, G. Deng, K. Nakajima, Z. L. Tabatabai, N. Ishii, and R. Dahiya. 2015. Long noncoding RNA MALAT1 promotes aggressive renal cell carcinoma through Ezh2 and interacts with miR-205. Cancer Research 75 (7):1322–31. doi: 10.1158/0008-5472.CAN-14-2931.
  • Ho, T.-T., J. Huang, N. Zhou, Z. Zhang, P. Koirala, X. Zhou, F. Wu, X. Ding, and Y.-Y. Mo. 2016. Regulation of PCGEM1 by p54/nrb in prostate cancer. Scientific Reports 6 (1):1–11. doi: 10.1038/srep34529.
  • Honari, M., R. Shafabakhsh, R. J. Reiter, H. Mirzaei, and Z. Asemi. 2019. Resveratrol is a promising agent for colorectal cancer prevention and treatment: Focus on molecular mechanisms. Cancer Cell International 19 (1):1–8. doi: 10.1186/s12935-019-0906-y.
  • Hu, D. L., G. Wang, J. Yu, L. H. Zhang, Y. F. Huang, D. Wang, et al. 2019. Epigallocatechin-3-gallate modulates long non-coding RNA and mRNA expression profiles in lung cancer cells. Molecular Medicine Reports 19 (3):1509–20.
  • Hu, T., Z. Fei, H. Su, R. Xie, and L. Chen. 2019. Polydatin inhibits proliferation and promotes apoptosis of doxorubicin-resistant osteosarcoma through LncRNA TUG1 mediated suppression of Akt signaling. Toxicology and Applied Pharmacology 371:55–62. doi: 10.1016/j.taap.2019.04.005.
  • Hu, Y., Z. Ma, Y. He, W. Liu, Y. Su, and Z. Tang. 2017. LncRNA-SNHG1 contributes to gastric cancer cell proliferation by regulating DNMT1. Biochemical and Biophysical Research Communications 491 (4):926–31. doi: 10.1016/j.bbrc.2017.07.137.
  • Hu, Z., P. Zhao, and H. Xu. 2020. Hyperoside exhibits anticancer activity in non-small cell lung cancer cells with T790M mutations by upregulating FoxO1 via CCAT1. Oncology Reports 43 (2):617–24.
  • Huang, G., X. Wu, S. Li, X. Xu, H. Zhu, and X. Chen. 2016. The long noncoding RNA CASC2 functions as a competing endogenous RNA by sponging miR-18a in colorectal cancer. Scientific Reports 6 (1):1–11. doi: 10.1038/srep26524.
  • Huang, J.-K., L. Ma, W.-H. Song, B.-Y. Lu, Y.-B. Huang, H.-M. Dong, X.-K. Ma, Z.-Z. Zhu, and R. Zhou. 2017. LncRNA-MALAT1 promotes angiogenesis of thyroid cancer by modulating tumor-associated macrophage FGF2 protein secretion. Journal of Cellular Biochemistry 118 (12):4821–30. doi: 10.1002/jcb.26153.
  • Huang, Y., R. M. Sramkoski, and J. W. Jacobberger. 2013. The kinetics of G2 and M transitions regulated by B cyclins. PLoS One 8 (12):e80861. doi: 10.1371/journal.pone.0080861.
  • Huarte, M. 2015. The emerging role of lncRNAs in cancer. Nature Medicine 21 (11):1253–61. doi: 10.1038/nm.3981.
  • Imai-Sumida, M., P. Dasgupta, P. Kulkarni, M. Shiina, Y. Hashimoto, V. Shahryari, et al. 2020. Genistein represses HOTAIR/chromatin remodeling pathways to suppress kidney cancer. Cellular Physiology and Biochemistry: international Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology 54 (1):53.
  • Imai-Sumida, M., T. Chiyomaru, S. Majid, S. Saini, H. Nip, R. Dahiya, Y. Tanaka, and S. Yamamura. 2017. Silibinin suppresses bladder cancer through down-regulation of actin cytoskeleton and PI3K/Akt signaling pathways. Oncotarget 8 (54):92032–42. doi: 10.18632/oncotarget.20734.
  • Inamura, K. 2017. Major tumor suppressor and oncogenic non-coding RNAs: Clinical relevance in lung cancer. Cells 6 (2):12. doi: 10.3390/cells6020012.
  • Jeong, D., J. Ham, S. Park, H. W. Kim, H. Kim, H. W. Ji, and S. J. Kim. 2019. Ginsenoside Rh2 suppresses breast cancer cell proliferation by epigenetically regulating the long noncoding RNA C3orf67-AS1. The American Journal of Chinese Medicine 47 (7):1643–58. doi: 10.1142/S0192415X19500848.
  • Ji, Q., X. Liu, X. Fu, L. Zhang, H. Sui, L. Zhou, J. Sun, J. Cai, J. Qin, J. Ren, et al. 2013. Resveratrol inhibits invasion and metastasis of colorectal cancer cells via MALAT1 mediated Wnt/β-catenin signal pathway. PloS One 8 (11):e78700. doi: 10.1371/journal.pone.0078700.
  • Jiang, P., A. Chen, X. Wu, M. Zhou, I. Ul Haq, Z. Mariyam, and Q. Feng. 2018. NEAT1 acts as an inducer of cancer stem cell-like phenotypes in NSCLC by inhibiting EGCG-upregulated CTR1. Journal of Cellular Physiology 233 (6):4852–63. doi: 10.1002/jcp.26288.
  • Jiang, P., X. Wu, X. Wang, W. Huang, and Q. Feng. 2016. NEAT1 upregulates EGCG-induced CTR1 to enhance cisplatin sensitivity in lung cancer cells. Oncotarget 7 (28):43337–51. doi: 10.18632/oncotarget.9712.
  • Jiang, Z., C. Jiang, and J. Fang. 2018. Up-regulated lnc-SNHG1 contributes to osteosarcoma progression through sequestration of miR-577 and activation of WNT2B/Wnt/β-catenin pathway. Biochemical and Biophysical Research Communications 495 (1):238–45. doi: 10.1016/j.bbrc.2017.11.012.
  • Johnson, G. S., J. Li, L. M. Beaver, W. M. Dashwood, D. Sun, P. Rajendran, D. E. Williams, E. Ho, and R. H. Dashwood. 2017. A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane‐treated colon cancer cells. Molecular Nutrition & Food Research 61 (4):1600769. doi: 10.1002/mnfr.201600769.
  • Jun, T., F. Zheng, K. Ren, H. Zhang, J. Zhao, and J. Zhao. 2018. Long non-coding RNA UCA1 regulates the proliferation, migration and invasion of human lung cancer cells by modulating the expression of microRNA-143. European Review for Medical and Pharmacological Sciences 22 (23):8343–52.
  • Karimi, P., F. Islami, S. Anandasabapathy, N. D. Freedman, and F. Kamangar. 2014. Gastric cancer: Descriptive epidemiology, risk factors, screening, and prevention. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 23 (5):700–13. doi: 10.1158/1055-9965.EPI-13-1057.
  • Kasai, A., N. Hiramatsu, K. Hayakawa, J. Yao, S. Maeda, and M. Kitamura. 2006. High levels of dioxin-like potential in cigarette smoke evidenced by in vitro and in vivo biosensing. Cancer Research 66 (14):7143–50. doi: 10.1158/0008-5472.CAN-05-4541.
  • Khalil, A. M., M. Guttman, M. Huarte, M. Garber, A. Raj, D. Rivea Morales, K. Thomas, A. Presser, B. E. Bernstein, A. van Oudenaarden, et al. 2009. Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proceedings of the National Academy of Sciences of the United States of America 106 (28):11667–72. doi: 10.1073/pnas.0904715106.
  • Khan, N., F. Afaq, M. Saleem, N. Ahmad, and H. Mukhtar. 2006. Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate. Cancer Research 66 (5):2500–5. doi: 10.1158/0008-5472.CAN-05-3636.
  • Kim, H., H. W. Ji, H. W. Kim, S. H. Yun, J. E. Park, and S. J. Kim. 2021. Ginsenoside Rg3 prevents oncogenic long noncoding RNA ATXN8OS from inhibiting tumor-suppressive microRNA-424-5p in breast cancer cells. Biomolecules 11 (1):118. doi: 10.3390/biom11010118.
  • Kong, L., X. Li, H. Wang, G. He, and A. Tang. 2018. Calycosin inhibits nasopharyngeal carcinoma cells by influencing EWSAT1 expression to regulate the TRAF6-related pathways. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 106:342–8. doi: 10.1016/j.biopha.2018.06.143.
  • Kornienko, A. E., P. M. Guenzl, D. P. Barlow, and F. M. Pauler. 2013. Gene regulation by the act of long non-coding RNA transcription. BMC Biology 11 (1):59. doi: 10.1186/1741-7007-11-59.
  • Kotake, Y., M. Naemura, K. Kitagawa, H. Niida, T. Tsunoda, S. Shirasawa, and M. Kitagawa. 2016. Oncogenic Ras influences the expression of multiple lncRNAs. Cytotechnology 68 (4):1591–6. doi: 10.1007/s10616-014-9834-9.
  • Kung, J. T., D. Colognori, and J. T. Lee. 2013. Long noncoding RNAs: Past, present, and future. Genetics 193 (3):651–69. doi: 10.1534/genetics.112.146704.
  • Lan, X., and X. Liu. 2019. LncRNA SNHG1 functions as a ceRNA to antagonize the effect of miR-145a-5p on the down-regulation of NUAK1 in nasopharyngeal carcinoma cell . Journal of Cellular and Molecular Medicine 23 (4):2351–61. doi: 10.1111/jcmm.13497.
  • Lapucci, A., M. Donnini, L. Papucci, E. Witort, A. Tempestini, A. Bevilacqua, A. Nicolin, G. Brewer, N. Schiavone, and S. Capaccioli. 2002. AUF1 Is a bcl-2 A + U-rich element-binding protein involved in bcl-2 mRNA destabilization during apoptosis. The Journal of Biological Chemistry 277 (18):16139–46. doi: 10.1074/jbc.M201377200.
  • Lee, J-e, S.-G. Cho, S.-G. Ko, S. A. Ahrmad, A. Puga, and K. Kim. 2020. Regulation of a long noncoding RNA MALAT1 by aryl hydrocarbon receptor in pancreatic cancer cells and tissues. Biochemical and Biophysical Research Communications 532 (4):563–9. doi: 10.1016/j.bbrc.2020.08.053.
  • Li, D., S. Hao, and J. Zhang. 2019. Long non-coding RNA UCA1 exerts growth modulation by miR-15a in human thyroid cancer TPC-1 cells. Artificial Cells, Nanomedicine, and Biotechnology 47 (1):1815–22. doi: 10.1080/21691401.2019.1606007.
  • Li, J. P., Y. Xiang, L. J. Fan, A. Yao, H. Li, and X. H. Liao. 2019. Long noncoding RNA H19 competitively binds miR-93-5p to regulate STAT3 expression in breast cancer. Journal of Cellular Biochemistry 120 (3):3137–48. doi: 10.1002/jcb.27578.
  • Li, J., and Y. Qi. 2019. Ginsenoside Rg3 inhibits cell growth, migration and invasion in Caco-2 cells by downregulation of lncRNA CCAT1. Experimental and Molecular Pathology 106:131–8. doi: 10.1016/j.yexmp.2019.01.003.
  • Li, J., Z. Zhang, L. Xiong, C. Guo, T. Jiang, L. Zeng, G. Li, and J. Wang. 2017. SNHG1 lncRNA negatively regulates miR-199a-3p to enhance CDK7 expression and promote cell proliferation in prostate cancer. Biochemical and Biophysical Research Communications 487 (1):146–52. doi: 10.1016/j.bbrc.2017.03.169.
  • Li, S., Y. Li, B. Chen, J. Zhao, S. Yu, Y. Tang, Q. Zheng, Y. Li, P. Wang, X. He, et al. 2018. exoRBase: A database of circRNA, lncRNA and mRNA in human blood exosomes. Nucleic Acids Research 46 (D1):D106–D12. doi: 10.1093/nar/gkx891.
  • Li, Y., and C. Cheng. 2018. Long noncoding RNA NEAT1 promotes the metastasis of osteosarcoma via interaction with the G9a-DNMT1-Snail complex. American Journal of Cancer Research 8 (1):81–90.
  • Li, Y., Y. Li, S. Huang, K. He, M. Zhao, H. Lin, D. Li, J. Qian, C. Zhou, Y. Chen, et al. 2017. Long non-coding RNA growth arrest specific transcript 5 acts as a tumour suppressor in colorectal cancer by inhibiting interleukin-10 and vascular endothelial growth factor expression. Oncotarget 8 (8):13690–702. doi: 10.18632/oncotarget.14625.
  • Li, Z., H. Liu, Q. Zhong, J. Wu, and Z. Tang. 2018. Lnc RNA UCA 1 is necessary for TGF‐β‐induced epithelial–mesenchymal transition and stemness via acting as a ce RNA for Slug in glioma cells. FEBS Open Biology 8 (11):1855–65. doi: 10.1002/2211-5463.12533.
  • Li, Z., X. Li, S. Wu, M. Xue, and W. Chen. 2014. Long non-coding RNA UCA1 promotes glycolysis by upregulating hexokinase 2 through the mTOR-STAT3/microRNA143 pathway. Cancer Science 105 (8):951–5. doi: 10.1111/cas.12461.
  • Li, Z., Y. Li, Y. Li, K. Ren, X. Li, X. Han, and J. Wang. 2017. Long non‐coding RNA H19 promotes the proliferation and invasion of breast cancer through upregulating DNMT1 expression by sponging miR‐152. Journal of Biochemical and Molecular Toxicology 31 (9):e21933. doi: 10.1002/jbt.21933.
  • Liao, Z., J. Zhao, and Y. Yang. 2018. Downregulation of lncRNA H19 inhibits the migration and invasion of melanoma cells by inactivating the NF‑κB and PI3K/Akt signaling pathways. Molecular Medicine Reports 17 (5):7313–8. doi: 10.3892/mmr.2018.8782.
  • Licznerska, B., and W. Baer-Dubowska. 2016. Indole-3-carbinol and its role in chronic diseases. In: Gupta S., Prasad S., Aggarwal B. (eds) Anti-inflammatory Nutraceuticals and Chronic Diseases. Advances in Experimental Medicine and Biology 928:131–154. Springer, Cham. doi: 0.1007/978-3-319-41334-1_6
  • Liu, B., L. Sun, Q. Liu, C. Gong, Y. Yao, X. Lv, L. Lin, H. Yao, F. Su, D. Li, et al. 2015. A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis. Cancer Cell 27 (3):370–81. doi: 10.1016/j.ccell.2015.02.004.
  • Liu, C., Y. Lin, J. Xu, H. Chu, S. Hao, X. Liu, X. Song, L. Jiang, and H. Zheng. 2017. Luteolin suppresses tumor progression through lncRNA BANCR and its downstream TSHR/CCND1 signaling in thyroid carcinoma. International Journal of Clinical and Experimental Pathology 10 (9):9591–8.
  • Liu, D., Y. Li, G. Luo, X. Xiao, D. Tao, X. Wu, M. Wang, C. Huang, L. Wang, F. Zeng, et al. 2017. LncRNA SPRY4-IT1 sponges miR-101-3p to promote proliferation and metastasis of bladder cancer cells through up-regulating EZH2. Cancer Letters 388:281–91. doi: 10.1016/j.canlet.2016.12.005.
  • Liu, G., T. Xiang, Q. F. Wu, and W. X. Wang. 2016. Curcumin suppresses the proliferation of gastric cancer cells by downregulating H19. Oncology Letters 12 (6):5156–62. doi: 10.3892/ol.2016.5354.
  • Liu, H., H. Deng, Y. Zhao, C. Li, and Y. Liang. 2018. LncRNA XIST/miR-34a axis modulates the cell proliferation and tumor growth of thyroid cancer through MET-PI3K-AKT signaling. Journal of Experimental & Clinical Cancer Research 37 (1):1–12. doi: 10.1186/s13046-018-0950-9.
  • Liu, H., Y. Dong, Y. Gao, Z. Du, Y. Wang, P. Cheng, A. Chen, and H. Huang. 2016. The fascinating effects of baicalein on cancer: A review. International Journal of Molecular Sciences 17 (10):1681. doi: 10.3390/ijms17101681.
  • Liu, L., S. Cui, T. Wan, X. Li, W. Tian, R. Zhang, L. Luo, and Y. Shi. 2018. Long non-coding RNA HOTAIR acts as a competing endogenous RNA to promote glioma progression by sponging miR-126-5p . Journal of Cellular Physiology 233 (9):6822–31. doi: 10.1002/jcp.26432.
  • Liu, Q., J. Huang, N. Zhou, Z. Zhang, A. Zhang, Z. Lu, F. Wu, and Y.-Y. Mo. 2013. LncRNA loc285194 is a p53-regulated tumor suppressor. Nucleic Acids Research 41 (9):4976–87. doi: 10.1093/nar/gkt182.
  • Liu, T., H. Chi, J. Chen, C. Chen, Y. Huang, H. Xi, J. Xue, and Y. Si. 2017. Curcumin suppresses proliferation and in vitro invasion of human prostate cancer stem cells by ceRNA effect of miR-145 and lncRNA-ROR. Gene 631:29–38. doi: 10.1016/j.gene.2017.08.008.
  • Liu, Y., H. Sun, B. Makabel, Q. Cui, J. Li, C. Su, C. R. Ashby, Z. Chen, and J. Zhang. 2019. The targeting of non‑coding RNAs by curcumin: Facts and hopes for cancer therapy (Review). Oncology Reports 42 (1):20–34. doi: 10.3892/or.2019.7148.
  • Lu, M., Z. Liu, B. Li, G. Wang, D. Li, and Y. Zhu. 2017. The high expression of long non-coding RNA PANDAR indicates a poor prognosis for colorectal cancer and promotes metastasis by EMT pathway. Journal of Cancer Research and Clinical Oncology 143 (1):71–81. doi: 10.1007/s00432-016-2252-y.
  • Lu, X., D. Chen, F. Yang, and N. Xing. 2020. Quercetin inhibits epithelial-to-mesenchymal transition (EMT) process and promotes apoptosis in prostate cancer via downregulating lncRNA MALAT1. Cancer Management and Research 12:1741–50. doi: 10.2147/CMAR.S241093.
  • Luan, W., Z. Zhou, X. Ni, Y. Xia, J. Wang, Y. Yan, and B. Xu. 2018. Long non-coding RNA H19 promotes glucose metabolism and cell growth in malignant melanoma via miR-106a-5p/E2F3 axis. Journal of Cancer Research and Clinical Oncology 144 (3):531–42. doi: 10.1007/s00432-018-2582-z.
  • Lubelsky, Y., and I. Ulitsky. 2018. Sequences enriched in Alu repeats drive nuclear localization of long RNAs in human cells. Nature 555 (7694):107–11. doi: 10.1038/nature25757.
  • Luo, Y., B. Yan, L. Liu, L. Yin, H. Ji, X. An, J. Gladkich, Z. Qi, C. De La Torre, and I. Herr. 2021. Sulforaphane inhibits the expression of long noncoding RNA H19 and its target APOBEC3G and thereby pancreatic cancer progression. Cancers 13 (4):827. doi: 10.3390/cancers13040827.
  • Lv, L., J.-Q. Jia, and J. Chen. 2018. The lncRNA CCAT1 upregulates proliferation and invasion in melanoma cells via suppressing miR-33a. Oncology Research 26 (2):201–8. doi: 10.3727/096504017X14920318811749.
  • Ma, L., F. Wang, C. Du, Z. Zhang, H. Guo, X. Xie, H. Gao, Y. Zhuang, M. Kornmann, H. Gao, et al. 2018. Long non-coding RNA MEG3 functions as a tumour suppressor and has prognostic predictive value in human pancreatic cancer. Oncology Reports 39 (3):1132–40. doi: 10.3892/or.2018.6178.
  • Mansoori, B., A. Mohammadi, S. Davudian, S. Shirjang, and B. Baradaran. 2017. The different mechanisms of cancer drug resistance: A brief review. Advanced Pharmaceutical Bulletin 7 (3):339–48. doi: 10.15171/apb.2017.041.
  • Mao, J., S. Fan, W. Ma, P. Fan, B. Wang, J. Zhang, H. Wang, B. Tang, Q. Zhang, X. Yu, et al. 2014. Roles of Wnt/β-catenin signaling in the gastric cancer stem cells proliferation and salinomycin treatment. Cell Death & Disease 5 (1):e1039. doi: 10.1038/cddis.2013.515.
  • Meeran, S. M., A. Ahmed, and T. O. Tollefsbol. 2010. Epigenetic targets of bioactive dietary components for cancer prevention and therapy. Clinical Epigenetics 1 (3–4):101–16. doi: 10.1007/s13148-010-0011-5.
  • Melé, M., K. Mattioli, W. Mallard, D. M. Shechner, C. Gerhardinger, and J. L. Rinn. 2017. Chromatin environment, transcriptional ­regulation, and splicing distinguish lincRNAs and mRNAs. Genome Research 27 (1):27–37. doi: 10.1101/gr.214205.116.
  • Mishra, S., S. S. Verma, V. Rai, N. Awasthee, S. Chava, K. M. Hui, A. P. Kumar, K. B. Challagundla, G. Sethi, and S. C. Gupta. 2019. Long non-coding RNAs are emerging targets of phytochemicals for cancer and other chronic diseases. Cellular and Molecular Life Sciences : CMLS 76 (10):1947–66. doi: 10.1007/s00018-019-03053-0.
  • Morais, S., K. Silva, H. Araujo, I. Vieira, D. Alves, R. Fontenelle, and A. Silva. 2017. Anacardic acid constituents from cashew nut shell liquid: NMR characterization and the effect of unsaturation on its biological activities. Pharmaceuticals 10 (4):31. doi: 10.3390/ph10010031.
  • Murthy, M. M., M. Subramanyam, K. Giridhar, and A. Jetty. 2006. Antimicrobial activities of bharangin from Premna herbaceae Roxb. and bharangin monoacetate. Journal of Ethnopharmacology 104 (1–2):290–2. doi: 10.1016/j.jep.2005.09.015.
  • Nakhjavani, M., J. E. Hardingham, H. M. Palethorpe, Y. Tomita, E. Smith, T. J. Price, and A. R. Townsend. 2019. Ginsenoside Rg3: Potential molecular targets and therapeutic indication in metastatic breast cancer. Medicines 6 (1):17. doi: 10.3390/medicines6010017.
  • Noh, J. H., K. M. Kim, K. Abdelmohsen, J.-H. Yoon, A. C. Panda, R. Munk, J. Kim, J. Curtis, C. A. Moad, C. M. Wohler, et al. 2016. HuR and GRSF1 modulate the nuclear export and mitochondrial localization of the lncRNA RMRP. Genes & Development 30 (10):1224–39.
  • Nojima, T., M. Tellier, J. Foxwell, C. Ribeiro de Almeida, S. M. Tan-Wong, S. Dhir, G. Dujardin, A. Dhir, S. Murphy, and N. J. Proudfoot. 2018. Deregulated expression of mammalian lncRNA through loss of SPT6 induces R-loop formation, replication stress, and cellular senescence. Molecular Cell 72 (6):970–84. e7. doi: 10.1016/j.molcel.2018.10.011.
  • Palazzo, A. F., and E. S. Lee. 2015. Non-coding RNA: What is functional and what is junk? Frontiers in Genetics 6:2. doi: 10.3389/fgene.2015.00002.
  • Paraskevopoulou, M. D., and A. G. Hatzigeorgiou. 2016. Analyzing miRNA–lncRNA interactions long non-coding RNAs, Feng Y., L. Zhang (eds) Long Non-Coding RNAs. Methods in Molecular Biology. 1402:271–276. Humana Press, New York, NY.
  • Park, J. E., H. W. Kim, S. H. Yun, and S. J. Kim. 2021. Ginsenoside Rh2 upregulates long noncoding RNA STXBP5-AS1 to sponge microRNA-4425 in suppressing breast cancer cell proliferation. Journal of Ginseng Research 45 (6):754–62. doi: 10.1016/j.jgr.2021.08.006.
  • Parrow, N. L., and R. E. Fleming. 2021. RNF217: Brokering ferroportin degradation. Blood, the Journal of the American Society of Hematology 138 (8):593–4.
  • Pei, C.-S., H.-Y. Wu, F.-T. Fan, Y. Wu, C.-S. Shen, and L.-Q. Pan. 2014. Influence of curcumin on HOTAIR-mediated migration of human renal cell carcinoma cells. Asian Pacific Journal of Cancer Prevention: APJCP 15 (10):4239–43. doi: 10.7314/apjcp.2014.15.10.4239.
  • Peng, W., Z. Wang, and H. Fan. 2017. LncRNA NEAT1 impacts cell proliferation and apoptosis of colorectal cancer via regulation of Akt signaling. Pathology & Oncology Research 23 (3):651–6. doi: 10.1007/s12253-016-0172-4.
  • Pickard, M. R., and G. T. Williams. 2014. Regulation of apoptosis by long non-coding RNA GAS5 in breast cancer cells: Implications for chemotherapy. Breast Cancer Research and Treatment 145 (2):359–70. doi: 10.1007/s10549-014-2974-y.
  • Polachi, N., G. Bai, T. Li, Y. Chu, X. Wang, S. Li, N. Gu, J. Wu, W. Li, Y. Zhang, et al. 2016. Modulatory effects of silibinin in various cell signaling pathways against liver disorders and cancer - A comprehensive review. European Journal of Medicinal Chemistry 123:577–95. doi: 10.1016/j.ejmech.2016.07.070.
  • Prensner, J. R., M. K. Iyer, O. A. Balbin, S. M. Dhanasekaran, Q. Cao, J. C. Brenner, B. Laxman, I. A. Asangani, C. S. Grasso, H. D. Kominsky, et al. 2011. Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression. Nature Biotechnology 29 (8):742–9. doi: 10.1038/nbt.1914.
  • Pu, Z., F. Ge, Y. Wang, Z. Jiang, S. Zhu, S. Qin, Q. Dai, H. Liu, and H. Hua. 2021. Ginsenoside-Rg3 inhibits the proliferation and invasion of hepatoma carcinoma cells via regulating long non-coding RNA HOX antisense intergenic. Bioengineered 12 (1):2398–409. doi: 10.1080/21655979.2021.1932211.
  • Pylayeva-Gupta, Y., E. Grabocka, and D. Bar-Sagi. 2011. RAS oncogenes: Weaving a tumorigenic web. Nature Reviews. Cancer 11 (11):761–74. doi: 10.1038/nrc3106.
  • Qi, L., F. Liu, F. Zhang, S. Zhang, LYan Lv, Y. Bi, and Y. Yu. 2018. lncRNA NEAT1 competes against let-7a to contribute to non-small cell lung cancer proliferation and metastasis. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 103:1507–15. doi: 10.1016/j.biopha.2018.04.053.
  • Qu, L., J. Ding, C. Chen, Z.-J. Wu, B. Liu, Y. Gao, W. Chen, F. Liu, W. Sun, X.-F. Li, et al. 2016. Exosome-transmitted lncARSR promotes sunitinib resistance in renal cancer by acting as a competing endogenous RNA. Cancer Cell 29 (5):653–68. doi: 10.1016/j.ccell.2016.03.004.
  • Quinn, J. J., Q. C. Zhang, P. Georgiev, I. A. Ilik, A. Akhtar, and H. Y. Chang. 2016. Rapid evolutionary turnover underlies conserved lncRNA-genome interactions. Genes & Development 30 (2):191–207. doi: 10.1101/gad.272187.115.
  • Rathinasamy, B., and B. K. Velmurugan. 2018. Role of lncRNAs in the cancer development and progression and their regulation by various phytochemicals. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 102:242–8. doi: 10.1016/j.biopha.2018.03.077.
  • Ravishankar, D., A. K. Rajora, F. Greco, and H. M. Osborn. 2013. Flavonoids as prospective compounds for anti-cancer therapy. The International Journal of Biochemistry & Cell Biology 45 (12):2821–31. doi: 10.1016/j.biocel.2013.10.004.
  • Raza, A., X. Xu, H. Sun, J. Tang, and Z. Ouyang. 2017. Pharmacological activities and pharmacokinetic study of hyperoside: A short review. Tropical Journal of Pharmaceutical Research 16 (2):483–9. doi: 10.4314/tjpr.v16i2.30.
  • Reddy, K. B. 2015. MicroRNA (miRNA) in cancer. Cancer Cell International 15 (1):1–6. doi: 10.1186/s12935-015-0185-1.
  • Reddy, L., B. Odhav, and K. Bhoola. 2003. Natural products for cancer prevention: A global perspective. Pharmacology & Therapeutics 99 (1):1–13. doi: 10.1016/s0163-7258(03)00042-1.
  • Reyes-Farias, M., and C. Carrasco-Pozo. 2019. The anti-cancer effect of quercetin: Molecular implications in cancer metabolism. International Journal of Molecular Sciences 20 (13):3177. doi: 10.3390/ijms20133177.
  • Safe, S., S.-O. Lee, and U.-H. Jin. 2013. Role of the aryl hydrocarbon receptor in carcinogenesis and potential as a drug target. Toxicological Sciences : An Official Journal of the Society of Toxicology 135 (1):1–16. doi: 10.1093/toxsci/kft128.
  • Saghafi, T., R. A. Taheri, S. Parkkila, and E. R. Zolfaghari. 2019. Phytochemicals as modulators of long non-coding RNAs and inhibitors of cancer-related carbonic anhydrases. International Journal of Molecular Sciences 20 (12):2939. doi: 10.3390/ijms20122939.
  • Sanchez Calle, A., Y. Kawamura, Y. Yamamoto, F. Takeshita, and T. Ochiya. 2018. Emerging roles of long non-coding RNA in cancer. Cancer Science 109 (7):2093–100. doi: 10.1111/cas.13642.
  • Sánchez, Y., V. Segura, O. Marín-Béjar, A. Athie, F. P. Marchese, J. González, L. Bujanda, S. Guo, A. Matheu, and M. Huarte. 2014. Genome-wide analysis of the human p53 transcriptional network unveils a lncRNA tumour suppressor signature. Nature Communications 5 (1):1–13. doi: 10.1038/ncomms6812.
  • Schlackow, M., T. Nojima, T. Gomes, A. Dhir, M. Carmo-Fonseca, and N. J. Proudfoot. 2017. Distinctive patterns of transcription and RNA processing for human lincRNAs. Molecular Cell 65 (1):25–38. doi: 10.1016/j.molcel.2016.11.029.
  • Schultz, D. J., A. Krishna, S. L. Vittitow, N. Alizadeh-Rad, P. Muluhngwi, E. C. Rouchka, and C. M. Klinge. 2018. Transcriptomic response of breast cancer cells to anacardic acid. Scientific Reports 8 (1):1–16. doi: 10.1038/s41598-018-26429-x.
  • Seyed Hosseini, E., M. Alizadeh Zarei, S. Babashah, R. Nakhaei Sistani, M. Sadeghizadeh, H. Haddad Kashani, J. Amini Mahabadi, F. Izadpanah, M. A. Atlasi, and H. Nikzad. 2019. Studies on combination of oxaliplatin and dendrosomal nanocurcumin on proliferation, apoptosis induction, and long non-coding RNA expression in ovarian cancer cells. Cell Biology and Toxicology 35 (3):247–66. doi: 10.1007/s10565-018-09450-8.
  • Shafabakhsh, R., and Z. Asemi. 2019. Quercetin: A natural compound for ovarian cancer treatment. Journal of Ovarian Research 12 (1):1–9. doi: 10.1186/s13048-019-0530-4.
  • Shao, J., C.-J. Shi, Y. Li, F.-W. Zhang, F.-F. Pan, W.-M. Fu, and J.-F. Zhang. 2020. LincROR mediates the suppressive effects of curcumin on hepatocellular carcinoma through inactivating Wnt/β-catenin signaling. Frontiers in Pharmacology 11 (847):847.
  • Shen, J., L. Hong, D. Yu, T. Cao, Z. Zhou, and S. He. 2019. LncRNA XIST promotes pancreatic cancer migration, invasion and EMT by sponging miR-429 to modulate ZEB1 expression. The International Journal of Biochemistry & Cell Biology 113:17–26. doi: 10.1016/j.biocel.2019.05.021.
  • Si, Y., Z. Yang, Q. Ge, L. Yu, M. Yao, X. Sun, Z. Ren, and C. Ding. 2019. Long non-coding RNA Malat1 activated autophagy, hence promoting cell proliferation and inhibiting apoptosis by sponging miR-101 in colorectal cancer. Cellular & Molecular Biology Letters 24 (1):1–12. doi: 10.1186/s11658-019-0175-8.
  • Siddiqui, I. A., M. Asim, B. B. Hafeez, V. M. Adhami, R. S. Tarapore, and H. Mukhtar. 2011. Green tea polyphenol EGCG blunts androgen receptor function in prostate cancer. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 25 (4):1198–207. doi: 10.1096/fj.10-167924.
  • Siegel, R. L., K. D. Miller, H. E. Fuchs, and A. Jemal. 2021. Cancer statistics, 2021. CA: A Cancer Journal for Clinicians 71 (1):7–33.
  • Sigler, K., and R. J. Ruch. 1993. Enhancement of gap junctional intercellular communication in tumor promoter-treated cells by components of green tea. Cancer Letters 69 (1):15–9. doi: 10.1016/0304-3835(93)90026-6.
  • Song, D., J. Hao, and D. Fan. 2020. Biological properties and clinical applications of berberine. Frontiers of Medicine 14 (5):564–19. doi: 10.1007/s11684-019-0724-6.
  • Song, H., P. He, T. Shao, Y. Li, J. Li, and Y. Zhang. 2017. Long non-coding RNA XIST functions as an oncogene in human colorectal cancer by targeting miR-132-3p. Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology 22 (3):696–703.
  • Song, J., H. Shu, L. Zhang, and J. Xiong. 2019. Long noncoding RNA GAS5 inhibits angiogenesis and metastasis of colorectal cancer through the Wnt/β‐catenin signaling pathway. Journal of Cellular Biochemistry 120 (5):6937–51. doi: 10.1002/jcb.27743.
  • Statello, L., C.-J. Guo, L.-L. Chen, and M. Huarte. 2021. Gene regulation by long non-coding RNAs and its biological functions. Nature Reviews. Molecular Cell Biology 22 (2):96–118. doi: 10.1038/s41580-020-00315-9.
  • Su, Q., J. Wang, Q. Wu, A. Ullah, M. A. Ghauri, A. Sarwar, L. Chen, F. Liu, and Y. Zhang. 2021. Sanguinarine combats hypoxia-induced activation of EphB4 and HIF-1α pathways in breast cancer. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 84:153503. doi: 10.1016/j.phymed.2021.153503.
  • Sun, G., Y. Wang, J. Zhang, N. Lin, and Y. You. 2018. MiR-15b/HOTAIR/p53 form a regulatory loop that affects the growth of glioma cells. Journal of Cellular Biochemistry 119 (6):4540–7. doi: 10.1002/jcb.26591.
  • Sun, K., Z. Jia, R. Duan, Z. Yan, Z. Jin, L. Yan, Q. Li, and J. Yang. 2019. Long non-coding RNA XIST regulates miR-106b-5p/P21 axis to suppress tumor progression in renal cell carcinoma. Biochemical and Biophysical Research Communications 510 (3):416–20. doi: 10.1016/j.bbrc.2019.01.116.
  • Sun, X., P. Du, W. Yuan, Z. Du, M. Yu, X. Yu, and T. Hu. 2015. Long non-coding RNA HOTAIR regulates cyclin J via inhibition of microRNA-205 expression in bladder cancer. Cell Death & Disease 6 (10):e1907. doi: 10.1038/cddis.2015.269.
  • Sun, Y., J. Tang, C. Li, J. Liu, and H. Liu. 2022. Sulforaphane attenuates dextran sodium sulphate induced intestinal inflammation via IL-10/STAT3 signaling mediated macrophage phenotype switching. Food Science and Human Wellness 11 (1):129–42. doi: 10.1016/j.fshw.2021.07.014.
  • Sun, Z., X. Wang, and Z. Xu. 2021. SIRT1 provides new pharmacological targets for polydatin through its role as a metabolic sensor. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 139:111549. doi: 10.1016/j.biopha.2021.111549.
  • Tan, H. Y., C. Wang, G. Liu, and X. Zhou. 2019. Long noncoding RNA NEAT1-modulated miR-506 regulates gastric cancer development through targeting STAT3. Journal of Cellular Biochemistry 120 (4):4827–36. doi: 10.1002/jcb.26691.
  • Tang, L., W. Zhang, B. Su, and B. Yu. 2013. Long noncoding RNA HOTAIR is associated with motility, invasion, and metastatic potential of metastatic melanoma. BioMed Research International 2013:251098. doi: 10.1155/2013/251098.
  • Teng, S., Y. Wang, P. Li, J. Liu, A. Wei, H. Wang, X. Meng, D. Pan, and X. Zhang. 2017. Effects of R type and S type ginsenoside Rg3 on DNA methylation in human hepatocarcinoma cells. Molecular Medicine Reports 15 (4):2029–38. doi: 10.3892/mmr.2017.6255.
  • Tian, B., and J. L. Manley. 2017. Alternative polyadenylation of mRNA precursors. Nature Reviews. Molecular Cell Biology 18 (1):18–30. doi: 10.1038/nrm.2016.116.
  • Tian, J., Y. Wang, X. Zhang, Q. Ren, R. Li, Y. Huang, et al. 2017. Calycosin inhibits the in vitro and in vivo growth of breast cancer cells through WDR7-7-GPR30 Signaling. Journal of Experimental & Clinical Cancer Research 36 (1):1–13.
  • Tomita, S., M. O. A. Abdalla, S. Fujiwara, H. Matsumori, K. Maehara, Y. Ohkawa, H. Iwase, N. Saitoh, and M. Nakao. 2015. A cluster of noncoding RNAs activates the ESR1 locus during breast cancer adaptation. Nature Communications 6 (1):1–15. doi: 10.1038/ncomms7966.
  • Tseng, Y.-Y., B. S. Moriarity, W. Gong, R. Akiyama, A. Tiwari, H. Kawakami, P. Ronning, B. Reuland, K. Guenther, T. C. Beadnell, et al. 2014. PVT1 dependence in cancer with MYC copy-number increase. Nature 512 (7512):82–6. doi: 10.1038/nature13311.
  • Ulitsky, I., and D. P. Bartel. 2013. lincRNAs: Genomics, evolution, and mechanisms. Cell 154 (1):26–46. doi: 10.1016/j.cell.2013.06.020.
  • Vallino, L., A. Ferraresi, C. Vidoni, E. Secomandi, A. Esposito, D. N. Dhanasekaran, and C. Isidoro. 2020. Modulation of non-coding RNAs by resveratrol in ovarian cancer cells: In silico analysis and literature review of the anti-cancer pathways involved. Journal of Traditional and Complementary Medicine 10 (3):217–29. doi: 10.1016/j.jtcme.2020.02.006.
  • Verma, M., S. Rogers, R. L. Divi, S. D. Schully, S. Nelson, L. Joseph Su, S. A. Ross, S. Pilch, D. M. Winn, and M. J. Khoury. 2014. Epigenetic research in cancer epidemiology: Trends, opportunities, and challenges. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 23 (2):223–33. doi: 10.1158/1055-9965.EPI-13-0573.
  • Wang, F., H.-Q. Ying, B.-S. He, Y.-Q. Pan, Q.-W. Deng, H.-L. Sun, J. Chen, X. Liu, and S.-K. Wang. 2015. Upregulated lncRNA-UCA1 contributes to progression of hepatocellular carcinoma through inhibition of miR-216b and activation of FGFR1/ERK signaling pathway. Oncotarget 6 (10):7899–917. doi: 10.18632/oncotarget.3219.
  • Wang, G., J. Sun, H. Zhao, and H. Li. 2018. Long non-coding RNA (lncRNA) growth arrest specific 5 (GAS5) suppresses esophageal squamous cell carcinoma cell proliferation and migration by inactivating phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research 24:7689–96. doi: 10.12659/MSM.910867.
  • Wang, H., Q. Shen, X. Zhang, C. Yang, S. Cui, Y. Sun, L. Wang, X. Fan, and S. Xu. 2017. The long non-coding RNA XIST controls non-small cell lung cancer proliferation and invasion by modulating miR-186-5p. Cell Physiology and Biochemistry 41 (6):2221–9. doi: 10.1159/000475637.
  • Wang, H.-M., J.-H. Lu, W.-Y. Chen, and A.-Q. Gu. 2015. Upregulated lncRNA-UCA1 contributes to progression of lung cancer and is closely related to clinical diagnosis as a predictive biomarker in plasma. International Journal of Clinical and Experimental Medicine 8 (7):11824.
  • Wang, K. C., and H. Y. Chang. 2011. Molecular mechanisms of long noncoding RNAs. Molecular Cell 43 (6):904–14. doi: 10.1016/j.molcel.2011.08.018.
  • Wang, M., C. Guo, L. Wang, G. Luo, C. Huang, Y. Li, D. Liu, F. Zeng, G. Jiang, and X. Xiao. 2018. Long noncoding RNA GAS5 promotes bladder cancer cells apoptosis through inhibiting EZH2 transcription. Cell Death & Disease 9 (2):1–16. doi: 10.1038/s41419-018-0264-z.
  • Wang, P., D. Chen, H. Ma, and Y. Li. 2017. LncRNA MEG3 enhances cisplatin sensitivity in non-small cell lung cancer by regulating miR-21-5p/SOX7 axis. OncoTargets and Therapy 10:5137–49. doi: 10.2147/OTT.S146423.
  • Wang, Q., H. Fan, Y. Liu, Z. Yin, H. Cai, J. Liu, Z. Wang, M. Shao, X. Sun, J. Diao, et al. 2014. Curcumin enhances the radiosensitivity in nasopharyngeal carcinoma cells involving the reversal of differentially expressed long non-coding RNAs. International Journal of Oncology 44 (3):858–64. doi: 10.3892/ijo.2013.2237.
  • Wang, Q., Q. Li, P. Zhou, D. Deng, L. Xue, N. Shao, Y. Peng, and F. Zhi. 2017. Upregulation of the long non-coding RNA SNHG1 predicts poor prognosis, promotes cell proliferation and invasion, and reduces apoptosis in glioma. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 91:906–11. doi: 10.1016/j.biopha.2017.05.014.
  • Wang, Q., W. Zhang, and S. Hao. 2017. LncRNA CCAT1 modulates the sensitivity of paclitaxel in nasopharynx cancers cells via miR-181a/CPEB2 axis. Cell Cycle (Georgetown, Tex.) 16 (8):795–801. doi: 10.1080/15384101.2017.1301334.
  • Wang, S.-H., F. Ma, Z-h Tang, X.-C. Wu, Q. Cai, M.-D. Zhang, M.-Z. Weng, D. Zhou, J.-D. Wang, and Z.-W. Quan. 2016. Long non-coding RNA H19 regulates FOXM1 expression by competitively binding endogenous miR-342-3p in gallbladder cancer. Journal of Experimental & Clinical Cancer Research 35 (1):1–12. doi: 10.1186/s13046-016-0436-6.
  • Wang, W., D. Chen, and K. Zhu. 2018. SOX2OT variant 7 contributes to the synergistic interaction between EGCG and Doxorubicin to kill osteosarcoma via autophagy and stemness inhibition. Journal of Experimental & Clinical Cancer Research: CR 37 (1):37–16. doi: 10.1186/s13046-018-0689-3.
  • Wang, W.-H., J. Chen, B.-R. Zhang, S.-J. Lu, F. Wang, L. Peng, et al. 2018. Curcumin inhibits proliferation and enhances apoptosis in A549 cells by downregulating lncRNA UCA1. Die Pharmazie-An International Journal of Pharmaceutical Sciences 73 (7):402–7.
  • Wang, W.-T., H. Ye, P.-P. Wei, B.-W. Han, B. He, Z.- H. Chen, and Y.-Q. Chen. 2016. LncRNAs H19 and HULC, activated by oxidative stress, promote cell migration and invasion in cholangiocarcinoma through a ceRNA manner. Journal of Hematology & Oncology 9 (1):1–12. doi: 10.1186/s13045-016-0348-0.
  • Wang, Y., W. Chen, J. Lian, H. Zhang, B. Yu, M. Zhang, F. Wei, J. Wu, J. Jiang, Y. Jia, et al. 2020. The lncRNA PVT1 regulates nasopharyngeal carcinoma cell proliferation via activating the KAT2A acetyltransferase and stabilizing HIF-1α. Cell Death and Differentiation 27 (2):695–710. doi: 10.1038/s41418-019-0381-y.
  • Wang, Y., W. Xie, M. Hou, J. Tian, X. Zhang, Q. Ren, Y. Huang, and J. Chen. 2021. Calycosin stimulates the proliferation of endothelial cells, but not breast cancer cells, via a feedback loop involving RP11-65M17.3, BRIP1 and ERα. Aging 13 (8):11026–11042. doi: 10.18632/aging.202641.
  • Wang, Z.-Q., Q. Cai, L. Hu, C.-Y. He, J.-F. Li, Z.-W. Quan, B.-Y. Liu, C. Li, and Z.-G. Zhu. 2017. Long noncoding RNA UCA1 induced by SP1 promotes cell proliferation via recruiting EZH2 and activating AKT pathway in gastric cancer. Cell Death & Disease 8 (6):e2839. doi: 10.1038/cddis.2017.143.
  • Wen, Q., Y. Liu, H. Lyu, X. Xu, Q. Wu, N. Liu, Q. Yin, J. Li, and X. Sheng. 2017. Long noncoding RNA GAS5, which acts as a tumor suppressor via microRNA 21, regulates cisplatin resistance expression in cervical cancer. International Journal of Gynecologic Cancer 27 (6):1096–108. doi: 10.1097/IGC.0000000000001028.
  • Whiteman, D. C., and L. F. Wilson. 2016. The fractions of cancer attributable to modifiable factors: A global review. Cancer Epidemiology 44:203–21. doi: 10.1016/j.canep.2016.06.013.
  • Wilusz, J. E., H. Sunwoo, and D. L. Spector. 2009. Long noncoding RNAs: Functional surprises from the RNA world. Genes & Development 23 (13):1494–504. doi: 10.1101/gad.1800909.
  • Wu, G., M. Niu, J. Qin, Y. Wang, and J. Tian. 2019. Inactivation of Rab27B-dependent signaling pathway by calycosin inhibits migration and invasion of ER-negative breast cancer cells. Gene 709:48–55. doi: 10.1016/j.gene.2019.04.005.
  • Wu, J., Y. Weng, F. He, D. Liang, and L. Cai. 2018. LncRNA MALAT-1 competitively regulates miR-124 to promote EMT and development of non-small-cell lung cancer. Anti-Cancer Drugs 29 (7):628–36. doi: 10.1097/CAD.0000000000000626.
  • Wu, M., Y. Huang, T. Chen, W. Wang, S. Yang, Z. Ye, and X. Xi. 2019. LncRNA MEG3 inhibits the progression of prostate cancer by modulating miR-9-5p/QKI-5 axis . Journal of Cellular and Molecular Medicine 23 (1):29–38. doi: 10.1111/jcmm.13658.
  • Wu, S., S. Powers, W. Zhu, and Y. A. Hannun. 2016. Substantial contribution of extrinsic risk factors to cancer development. Nature 529 (7584):43–7. doi: 10.1038/nature16166.
  • Wu, X., X. Dinglin, X. Wang, W. Luo, Q. Shen, Y. Li, L. Gu, Q. Zhou, H. Zhu, Y. Li, et al. 2017. Long noncoding RNA XIST promotes malignancies of esophageal squamous cell carcinoma via regulation of miR-101/EZH2. Oncotarget 8 (44):76015–28. doi: 10.18632/oncotarget.18638.
  • Xiao, D., X. Cui, and X. Wang. 2019. Long noncoding RNA XIST increases the aggressiveness of laryngeal squamous cell carcinoma by regulating miR-124-3p/EZH2. Experimental Cell Research 381 (2):172–8. doi: 10.1016/j.yexcr.2019.04.034.
  • Xin, X., M. Wu, Q. Meng, C. Wang, Y. Lu, Y. Yang, X. Li, Q. Zheng, H. Pu, X. Gui, et al. 2018. Long noncoding RNA HULC accelerates liver cancer by inhibiting PTEN via autophagy cooperation to miR15a. Molecular Cancer 17 (1):94–16. doi: 10.1186/s12943-018-0843-8.
  • Xu, F., Z. Ji, L. He, M. Chen, H. Chen, Q. Feng, B. Dong, X. Yang, L. Jiang, and R. Jin. 2020. Downregulation of LINC01021 by curcumin analog Da0324 inhibits gastric cancer progression through activation of P53. American Journal of Translational Research 12 (7):3429–3444.
  • Xue, Q., N. He, Z. Wang, X. Fu, L. H. H. Aung, Y. Liu, M. Li, J. Y. Cho, Y. Yang, and T. Yu. 2021. Functional roles and mechanisms of ginsenosides from Panax ginseng in atherosclerosis. Journal of Ginseng Research 45 (1):22–31. doi: 10.1016/j.jgr.2020.07.002.
  • Yang, H., P. Liu, J. Zhang, X. Peng, Z. Lu, S. Yu, Y. Meng, W.-M. Tong, and J. Chen. 2016. Long noncoding RNA MIR31HG exhibits oncogenic property in pancreatic ductal adenocarcinoma and is negatively regulated by miR-193b. Oncogene 35 (28):3647–57. doi: 10.1038/onc.2015.430.
  • Yang, H., S. Wang, Y.-J. Kang, C. Wang, Y. Xu, Y. Zhang, and Z. Jiang. 2018. Long non-coding RNA SNHG1 predicts a poor prognosis and promotes colon cancer tumorigenesis. Oncology Reports 40 (1):261–71. doi: 10.3892/or.2018.6412.
  • Yang, Q., E. Xu, J. Dai, B. Liu, Z. Han, J. Wu, S. Zhang, B. Peng, Y. Zhang, and Y. Jiang. 2015. A novel long noncoding RNA AK001796 acts as an oncogene and is involved in cell growth inhibition by resveratrol in lung cancer. Toxicology and Applied Pharmacology 285 (2):79–88. doi: 10.1016/j.taap.2015.04.003.
  • Yang, T., H. Zhai, R. Yan, Z. Zhou, L. Gao, and L. Wang. 2018. lncRNA CCAT1 promotes cell proliferation, migration, and invasion by down-regulation of miR-143 in FTC-133 thyroid carcinoma cell line. Brazilian Journal of Medical and Biological Research 51 (6):1–11. doi: 10.1590/1414-431x20187046.
  • Yang, T.-W., D. Sahu, Y.-W. Chang, C.-L. Hsu, C.-H. Hsieh, H.-C. Huang, and H.-F. Juan. 2019. RNA-binding proteomics reveals MATR3 interacting with lncRNA SNHG1 to enhance neuroblastoma progression. Journal of Proteome Research 18 (1):406–16.
  • Yang, W., R. E. Redpath, C. Zhang, and N. Ning. 2018. Long non-coding RNA H19 promotes the migration and invasion of colon cancer cells via MAPK signaling pathway. Oncology Letters 16 (3):3365–72. doi: 10.3892/ol.2018.9052.
  • Yang, X., E. Luo, X. Liu, B. Han, X. Yu, and X. Peng. 2016. Delphinidin-3-glucoside suppresses breast carcinogenesis by inactivating the Akt/HOTAIR signaling pathway. BMC Cancer 16 (1):1–8. doi: 10.1186/s12885-016-2465-0.
  • Yin, Y., J. Y. Lu, X. Zhang, W. Shao, Y. Xu, P. Li, Y. Hong, L. Cui, G. Shan, B. Tian, et al. 2020. U1 snRNP regulates chromatin retention of noncoding RNAs. Nature 580 (7801):147–50. doi: 10.1038/s41586-020-2105-3.
  • Yoshida, K., S. Toden, P. Ravindranathan, H. Han, and A. Goel. 2017. Curcumin sensitizes pancreatic cancer cells to gemcitabine by attenuating PRC2 subunit EZH2, and the lncRNA PVT1 expression. Carcinogenesis 38 (10):1036–46. doi: 10.1093/carcin/bgx065.
  • Yu, C., L. Longfei, W. Long, Z. Feng, J. Chen, L. Chao, L. Peihua, Z. Xiongbing, and C. Hequn. 2019. LncRNA PVT1 regulates VEGFC through inhibiting miR-128 in bladder cancer cells. Journal of Cellular Physiology 234 (2):1346–53. doi: 10.1002/jcp.26929.
  • Yu, H., Y. Xie, Z. Zhou, Z. Wu, X. Dai, and B. Xu. 2019. Curcumin regulates the progression of colorectal cancer via LncRNA NBR2/AMPK pathway. Technology in Cancer Research & Treatment 18:1533033819870781. doi: 10.1177/1533033819870781.
  • Yu, Q., X. Zhou, Q. Xia, J. Shen, J. Yan, J. Zhu, et al. 2016. Long non-coding RNA CCAT1 that can be activated by c-Myc promotes pancreatic cancer cell proliferation and migration. American Journal of Translational Research 8 (12):5444.
  • Yu, X., W. Tang, Y. Yang, L. Tang, R. Dai, B. Pu, C. Feng, and J. Xia. 2018. Long noncoding RNA NKILA enhances the anti-cancer effects of baicalein in hepatocellular carcinoma via the regulation of NF-κB signaling. Chemico-Biological Interactions 285:48–58. doi: 10.1016/j.cbi.2018.02.027.
  • Yu, X., Y. Cao, L. Tang, Y. Yang, F. Chen, and J. Xia. 2018. Baicalein inhibits breast cancer growth via activating a novel isoform of the long noncoding RNA PAX8-AS1-N. Journal of Cellular Biochemistry 119 (8):6842–56. doi: 10.1002/jcb.26881.
  • Yu, X., Y. Yang, Y. Li, Y. Cao, L. Tang, F. Chen, and J. Xia. 2018. Baicalein inhibits cervical cancer progression via downregulating long noncoding RNA BDLNR and its downstream PI3K/Akt pathway. The International Journal of Biochemistry & Cell Biology 94:107–18. doi: 10.1016/j.biocel.2017.11.009.
  • Yu, Z., Y. Jv, L. Cai, X. Tian, X. Huo, C. Wang, B. Zhang, C. Sun, J. Ning, L. Feng, et al. 2019. Gambogic acid attenuates liver fibrosis by inhibiting the PI3K/AKT and MAPK signaling pathways via inhibiting HSP90. Toxicology and Applied Pharmacology 371:63–73. doi: 10.1016/j.taap.2019.03.028.
  • Yuan, J., S. Che, Z. Ruan, L. Song, R. Tang, and L. Zhang. 2021. Regulatory effects of flavonoids luteolin on BDE-209-induced intestinal epithelial barrier damage in Caco-2 cell monolayer model. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 150:112098. doi: 10.1016/j.fct.2021.112098.
  • Yuan, P., W. Cao, Q. Zang, G. Li, X. Guo, and J. Fan. 2016. The HIF-2α-MALAT1-miR-216b axis regulates multi-drug resistance of hepatocellular carcinoma cells via modulating autophagy. Biochemical and Biophysical Research Communications 478 (3):1067–73. doi: 10.1016/j.bbrc.2016.08.065.
  • Zamani, M., M. Sadeghizadeh, M. Behmanesh, and F. Najafi. 2015. Dendrosomal curcumin increases expression of the long non-coding RNA gene MEG3 via up-regulation of epi-miRs in hepatocellular cancer. Phytomedicine 22 (10):961–7. doi: 10.1016/j.phymed.2015.05.071.
  • Zhang, A., N. Zhou, J. Huang, Q. Liu, K. Fukuda, D. Ma, Z. Lu, C. Bai, K. Watabe, and Y.-Y. Mo. 2013. The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage. Cell Research 23 (3):340–50. doi: 10.1038/cr.2012.164.
  • Zhang, D., G. Zhang, X. Hu, L. Wu, Y. Feng, S. He, Y. Zhang, Z. Hu, L. Yang, T. Tian, et al. 2017. Oncogenic RAS regulates long noncoding RNA Orilnc1 in human cancer. Cancer Research 77 (14):3745–57. doi: 10.1158/0008-5472.CAN-16-1768.
  • Zhang, J., J. Liu, X. Xu, and L. Li. 2017. Curcumin suppresses cisplatin resistance development partly via modulating extracellular vesicle-mediated transfer of MEG3 and miR-214 in ovarian cancer. Cancer Chemotherapy and Pharmacology 79 (3):479–87. doi: 10.1007/s00280-017-3238-4.
  • Zhang, J., X. Jin, C. Zhou, H. Zhao, P. He, Y. Hao, and Q. Dong. 2020. Resveratrol suppresses human nasopharyngeal carcinoma cell growth via inhibiting differentiation antagonizing non-protein coding RNA (DANCR) expression. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research 26:e923622. doi: 10.12659/MSM.923622.
  • Zhang, M.-L., W.-W. Liu, and W.-D. Li. 2021. Imbalance of Molecular Module of TINCR-miR-761 promotes the metastatic potential of early triple negative breast cancer and partially offsets the anti-tumor activity of luteolin. Cancer Management and Research 13:1877–86. doi: 10.2147/CMAR.S288271.
  • Zhang, S., G. Zhang, and J. Liu. 2016. Long noncoding RNA PVT1 promotes cervical cancer progression through epigenetically silencing miR-200b. APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica 124 (8):649–58. doi: 10.1111/apm.12555.
  • Zhang, S., T. Leng, Q. Zhang, Q. Zhao, X. Nie, and L. Yang. 2018. Sanguinarine inhibits epithelial ovarian cancer development via regulating long non-coding RNA CASC2-EIF4A3 axis and/or inhibiting NF-κB signaling or PI3K/AKT/mTOR pathway. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 102:302–8. doi: 10.1016/j.biopha.2018.03.071.
  • Zhang, W., B. J. Wagner, K. Ehrenman, A. W. Schaefer, C. T. DeMaria, D. Crater, K. DeHaven, L. Long, and G. Brewer. 1993. Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1. Molecular and Cellular Biology 13 (12):7652–65. doi: 10.1128/MCB.13.12.7652.
  • Zhang, Z., B. Li, P. Xu, and B. Yang. 2019. Integrated whole transcriptome profiling and bioinformatics analysis for revealing regulatory pathways associated with quercetin-induced apoptosis in HCT-116 cells. Frontiers in Pharmacology 10:798. doi: 10.3389/fphar.2019.00798.
  • Zhao, J., and L. Cheng. 2017. Long non-coding RNA CCAT1/miR-148a axis promotes osteosarcoma proliferation and migration through regulating PIK3IP1. Acta Biochimica et Biophysica Sinica 49 (6):503–12. doi: 10.1093/abbs/gmx041.
  • Zhao, J., P. Du, P. Cui, Y. Qin, C. Hu, J. Wu, Z. Zhou, W. Zhang, L. Qin, and G. Huang. 2018. LncRNA PVT1 promotes angiogenesis via activating the STAT3/VEGFA axis in gastric cancer. Oncogene 37 (30):4094–109. doi: 10.1038/s41388-018-0250-z.
  • Zhao, X., D. Tang, X. Chen, S. Chen, and C. Wang. 2021. Functional lncRNA-miRNA-mRNA Networks in Response to Baicalein Treatment in Hepatocellular Carcinoma. BioMed Research International 2021:8844261. doi: 10.1155/2021/8844261.
  • Zhao, X., Y. Liu, J. Zheng, X. Liu, J. Chen, L. Liu, P. Wang, and Y. Xue. 2017. GAS5 suppresses malignancy of human glioma stem cells via a miR-196a-5p/FOXO1 feedback loop. Biochimica et Biophysica Acta. Molecular Cell Research 1864 (10):1605–17. doi: 10.1016/j.bbamcr.2017.06.020.
  • Zhao, Y. C., Xiangbo, J. Jiang, X. Wan, W. Yuefei, and P. Xu. 2020. Epigallocatechin gallate reverses gemcitabine-resistant gastric cancer by regulating the long noncoding RNA LINC00511/miR-29b/KDM2A axis. Molecular Basis of Disease. 1866 (10):165856. doi: 10.1016/j.bbadis.2020.165856.
  • Zhao, Y., H. Sun, and H. Wang. 2016. Long noncoding RNAs in DNA methylation: New players stepping into the old game. Cell & Bioscience 6 (1):1–6. doi: 10.1186/s13578-016-0109-3.
  • Zheng, F., J. Li, CJu Ma, X. Tang, Q. Tang, J. Wu, XSu Chai, J. Xie, X.-B. Yang, and S. S. Hann. 2020. Novel regulation of miR-34a-5p and HOTAIR by the combination of berberine and gefitinib leading to inhibition of EMT in human lung cancer. Journal of Cellular and Molecular Medicine 24 (10):5578–92. doi: 10.1111/jcmm.15214.
  • Zheng, P., H. Li, P. Xu, X. Wang, Z. Shi, Q. Han, and Z. Li. 2018. High lncRNA HULC expression is associated with poor prognosis and promotes tumor progression by regulating epithelial-mesenchymal transition in prostate cancer. Archives of Medical Science 14 (3):679–86. doi: 10.5114/aoms.2017.69147.
  • Zheng, Q., Z. Lin, J. Xu, Y. Lu, Q. Meng, C. Wang, Y. Yang, X. Xin, X. Li, H. Pu, et al. 2018. Long noncoding RNA MEG3 suppresses liver cancer cells growth through inhibiting β-catenin by activating PKM2 and inactivating PTEN. Cell Death & Disease 9 (3):1–18. doi: 10.1038/s41419-018-0305-7.
  • Zheng, R., S. Lin, L. Guan, H. Yuan, K. Liu, C. Liu, W. Ye, Y. Liao, J. Jia, and R. Zhang. 2018. Long non-coding RNA XIST inhibited breast cancer cell growth, migration, and invasion via miR-155/CDX1 axis. Biochemical and Biophysical Research Communications 498 (4):1002–8. doi: 10.1016/j.bbrc.2018.03.104.
  • Zheng, X., Y. Zhou, W. Chen, L. Chen, J. Lu, F. He, X. Li, and L. Zhao. 2018. Ginsenoside 20(S)-Rg3 Prevents PKM2-Targeting miR-324-5p from H19 sponging to antagonize the warburg effect in ovarian cancer cells. Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology 51 (3):1340–53. doi: 10.1159/000495552.
  • Zheng, Z-h, H-y You, Y-j Feng, and Z-t Zhang. 2021. LncRNA KCNQ1OT1 is a key factor in the reversal effect of curcumin on cisplatin resistance in the colorectal cancer cells. Molecular and Cellular Biochemistry 476 (7):2575–85. doi: 10.1007/s11010-020-03856-x.
  • Zhou, X., S. Liu, G. Cai, L. Kong, T. Zhang, Y. Ren, Y. Wu, M. Mei, L. Zhang, X. Wang, et al. 2015. Long non coding RNA MALAT1 promotes tumor growth and metastasis by inducing epithelial-mesenchymal transition in oral squamous cell carcinoma. Scientific Reports 5 (1):15972–10. doi: 10.1038/srep15972.
  • Zhou, Y.-X., C. Wang, L.-W. Mao, Y.-L. Wang, L.-Q. Xia, W. Zhao, J. Shen, and J. Chen. 2018. Long noncoding RNA HOTAIR mediates the estrogen-induced metastasis of endometrial cancer cells via the miR-646/NPM1 axis. American Journal of Physiology. Cell Physiology 314 (6):C690–C701. doi: 10.1152/ajpcell.00222.2017.
  • Zhu, M., X. Wang, Y. Gu, F. Wang, L. Li, and X. Qiu. 2019. MEG3 overexpression inhibits the tumorigenesis of breast cancer by downregulating miR-21 through the PI3K/Akt pathway. Archives of Biochemistry and Biophysics 661:22–30. doi: 10.1016/j.abb.2018.10.021.
  • Zhu, Y., X. Zhang, L. Qi, Y. Cai, P. Yang, G. Xuan, and Y. Jiang. 2016. HULC long noncoding RNA silencing suppresses angiogenesis by regulating ESM-1 via the PI3K/Akt/mTOR signaling pathway in human gliomas. Oncotarget 7 (12):14429–40. doi: 10.18632/oncotarget.7418.
  • Zinovieva, O. L., E. N. Grineva, M. M. Prokofjeva, D. S. Karpov, G. S. Krasnov, V. S. Prassolov, T. D. Mashkova, and N. A. Lisitsyn. 2017. Treatment with anti-cancer agents results in profound changes in lncRNA expression in colon cancer cells. Molecular Biology 51 (5):733–9. doi: 10.1134/S0026893317050247.
  • Zou, J., H. Su, C. Zou, X. Liang, and Z. Fei. 2020. Ginsenoside Rg3 suppresses the growth of gemcitabine-resistant pancreatic cancer cells by upregulating lncRNA-CASC2 and activating PTEN signaling. Journal of Biochemical and Molecular Toxicology 34 (6):e22480. doi: 10.1002/jbt.22480.
  • Zou, M., J. Ling, Q. Wu, and C. Zhang. 2018. Long non-coding RNA PVT1 functions as an oncogene in ovarian cancer via upregulating SOX2. European Review for Medical and Pharmacological Sciences 22 (21):7183–8.
  • Zuckerman, B., M. Ron, M. Mikl, E. Segal, and I. Ulitsky. 2020. Gene architecture and sequence composition underpin selective dependency of nuclear export of long RNAs on NXF1 and the TREX complex. Molecular Cell 79 (2):251–67. e6. doi: 10.1016/j.molcel.2020.05.013.

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