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Probiotics act as a potent intervention in improving lipid profile: An umbrella systematic review and meta-analysis

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References

  • AbdelQadir, Y. H., A. Hamdallah, E. A. Sibaey, A. S. Hussein, M. Abdelaziz, A. AbdelAzim, K. M. Ragab, S. K. Helmy, and A. Z. Nourelden. 2020. Efficacy of probiotic supplementation in patients with diabetic nephropathy: A systematic review and meta-analysis. Clinical Nutrition ESPEN 40:57–67. doi: 10.1016/j.clnesp.2020.06.019.
  • Ahn, H. Y., M. Kim, J. S. Chae, Y. T. Ahn, J. H. Sim, I. D. Choi, S. H. Lee, and J. H. Lee. 2015. Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, reduces fasting triglycerides and enhances apolipoprotein A-V levels in non-diabetic subjects with hypertriglyceridemia. Atherosclerosis 241 (2):649–56. doi: 10.1016/j.atherosclerosis.2015.06.030.
  • Al-Sheraji, S. H., I. Amin, A. Azlan, M. Y. Manap, and F. A. Hassan. 2015. Effects of Bifidobacterium longum BB536 on lipid profile and histopathological changes in hypercholesterolaemic rats. Beneficial Microbes 6 (5):661–8. doi: 10.3920/BM2014.0032.
  • Andrade, C. 2020. Mean difference, Standardized Mean Difference (SMD), and their use in meta-analysis: As simple as it gets. Journal of Clinical Psychiatry 81 (5):20f13681. doi: 10.4088/JCP.20f13681.
  • Awney, H. A. 2011. The effects of Bifidobacteria on the lipid profile and oxidative stress biomarkers of male rats fed thermally oxidized soybean oil. Biomarkers 16 (5):445–52. doi: 10.3109/1354750X.2011.590228.
  • Banjoko, I. O., M. M. Adeyanju, O. Ademuyiwa, O. O. Adebawo, R. A. Olalere, M. O. Kolawole, I. A. Adegbola, T. A. Adesanmi, T. O. Oladunjoye, A. A. Ogunnowo, et al. 2012. Hypolipidemic effects of lactic acid bacteria fermented cereal in rats. Lipids in Health and Disease 11:170. doi: 10.1186/1476-511X-11-170.
  • Battaglini, D., P. M. Pimentel-Coelho, C. Robba, C. C. Dos Santos, F. F. Cruz, P. Pelosi, and P. R. M. Rocco. 2020. Gut microbiota in acute ischemic stroke: From pathophysiology to therapeutic implications. Frontiers in Neurology 11:598. doi: 10.3389/fneur.2020.00598.
  • Bernini, L. J., A. N. Simão, D. F. Alfieri, M. A. Lozovoy, N. L. Mari, C. H. de Souza, I. Dichi, and G. N. Costa. 2016. Beneficial effects of Bifidobacterium lactis on lipid profile and cytokines in patients with metabolic syndrome: A randomized trial. Effects of probiotics on metabolic syndrome. Nutrition (Burbank, Los Angeles County, CA) 32 (6):716–9. doi: 10.1016/j.nut.2015.11.001.
  • Bougarne, N., B. Weyers, S. J. Desmet, J. Deckers, D. W. Ray, B. Staels, and K. De Bosscher. 2018. Molecular actions of PPARα in lipid metabolism and inflammation. Endocrine Reviews 39 (5):760–802. doi: 10.1210/er.2018-00064.
  • Buglioni, A., and J. C. Burnett. 2013. A gut-heart connection in cardiometabolic regulation. Nature Medicine 19 (5):534–6. doi: 10.1038/nm.3196.
  • Cani, P. D., A. M. Neyrinck, F. Fava, C. Knauf, R. G. Burcelin, K. M. Tuohy, G. Gibson, and N. M. Delzenne. 2007. Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia 50 (11):2374–83. doi: 10.1007/s00125-007-0791-0.
  • Childs, C. E., H. Röytiö, E. Alhoniemi, A. A. Fekete, S. D. Forssten, N. Hudjec, Y. N. Lim, C. J. Steger, P. Yaqoob, K. M. Tuohy, et al. 2014. Xylo-oligosaccharides alone or in synbiotic combination with Bifidobacterium animalis subsp. lactis induce bifidogenesis and modulate markers of immune function in healthy adults: A double-blind, placebo-controlled, randomised, factorial cross-over study. The British Journal of Nutrition 111 (11):1945–56. doi: 10.1017/S0007114513004261.
  • Cho, Y. A., and J. Kim. 2015. Effect of probiotics on blood lipid concentrations: A meta-analysis of randomized controlled trials. Medicine 94 (43):e1714. doi: 10.1097/MD.0000000000001714.
  • Choi, I. D., S. H. Kim, J. W. Jeong, D. E. Lee, C. S. Huh, S. S. Hong, J. H. Sim, and Y. T. Ahn. 2016. Triglyceride-lowering effects of two probiotics, Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601, in a rat model of high-fat diet-induced hypertriglyceridemia. Journal of Microbiology and Biotechnology 26 (3):483–7. doi: 10.4014/jmb.1512.12018.
  • Clark, H. D., G. A. Wells, C. Huët, F. A. McAlister, L. R. Salmi, D. Fergusson, and A. Laupacis. 1999. Assessing the quality of randomized trials: Reliability of the Jadad scale. Controlled Clinical Trials 20 (5):448–52. doi: 10.1016/S0197-2456(99)00026-4.
  • Claudel, T., B. Staels, and F. Kuipers. 2005. The Farnesoid X receptor: A molecular link between bile acid and lipid and glucose metabolism. Arteriosclerosis, Thrombosis, and Vascular Biology 25 (10):2020–30. doi: 10.1161/01.ATV.0000178994.21828.a7.
  • Dayimu, A., C. Wang, J. Li, B. Fan, X. Ji, T. Zhang, and F. Xue. 2019. Trajectories of lipids profile and incident cardiovascular disease risk: A longitudinal cohort study. Journal of the American Heart Association 8 (21):e013479. doi: 10.1161/JAHA.119.013479.
  • de Almeida Silva, M., F. E. Mowry, S. C. Peaden, T. U. Andrade, and V. C. Biancardi. 2020. Kefir ameliorates hypertension via gut-brain mechanisms in spontaneously hypertensive rats. The Journal of Nutritional Biochemistry 77:108318. doi: 10.1016/j.jnutbio.2019.108318.
  • Dixon, A., K. Robertson, A. Yung, M. Que, H. Randall, D. Wellalagodage, T. Cox, D. Robertson, C. Chi, and J. Sun. 2020. Efficacy of probiotics in patients of cardiovascular disease risk: A systematic review and meta-analysis. Current Hypertension Reports 22 (9):1–27. doi: 10.1007/s11906-020-01080-y.
  • Dong, Y., M. Xu, L. Chen, and A. Bhochhibhoya. 2019. Probiotic foods and supplements interventions for metabolic syndromes: A systematic review and meta-analysis of recent clinical Trials. Annals of Nutrition & Metabolism 74 (3):224–41. doi: 10.1159/000499028.
  • Gadelha, C. J. M. U., and A. N. Bezerra. 2019. Effects of probiotics on the lipid profile: Systematic review. Jornal Vascular Brasileiro 18:e20180124. doi: 10.1590/1677-5449.180124.
  • Gao, X. L., Y. Zhu, Y. Wen, G. J. Liu, and C. M. Wan. 2016. Efficacy of probiotics in non-alcoholic fatty liver disease in adult and children: A meta-analysis of randomized controlled trials. Hepatology Research 46 (12):1226–33. doi: 10.1111/hepr.12671.
  • Ghaffari, S., and N. Roshanravan. 2020. The role of nutraceuticals in prevention and treatment of hypertension: An updated review of the literature. Food Research International (Ottawa, Ont.) 128:108749. doi: 10.1016/j.foodres.2019.108749.
  • Gomes, A. C., R. G. de Sousa, P. B. Botelho, T. L. Gomes, P. O. Prada, and J. F. Mota. 2017. The additional effects of a probiotic mix on abdominal adiposity and antioxidant Status: A double-blind, randomized trial. Obesity (Silver Spring) 25:30–8. doi: 10.1002/oby.21671.
  • Guo, Z., X. Liu, Q. Zhang, Z. Shen, F. Tian, H. Zhang, Z. Sun, H. Zhang, and W. Chen. 2011. Influence of consumption of probiotics on the plasma lipid profile: A meta-analysis of randomised controlled trials. Nutrition, Metabolism, and Cardiovascular Diseases: NMCD 21 (11):844–50. doi: 10.1016/j.numecd.2011.04.008.
  • Hadi, A., A. Arab, S. Khalesi, N. Rafie, M. Kafeshani, and M. Kazemi. 2021. Effects of probiotic supplementation on anthropometric and metabolic characteristics in adults with metabolic syndrome: A systematic review and meta-analysis of randomized clinical trials. Clinical Nutrition (Edinburgh, Scotland) 40 (7):4662–73. doi: 10.1016/j.clnu.2021.05.027.
  • Han, M.-M., J.-F. Sun, X.-H. Su, Y.-F. Peng, H. Goyal, C.-H. Wu, X.-Y. Zhu, and L. Li. 2019. Probiotics improve glucose and lipid metabolism in pregnant women: A meta-analysis. Annals of Translational Medicine 7 (5):99. doi: 10.21037/atm.2019.01.61.
  • He, J., F. Zhang, and Y. Han. 2017. Effect of probiotics on lipid profiles and blood pressure in patients with type 2 diabetes: A meta-analysis of RCTs. Medicine 96 (51):e9166. doi: 10.1097/MD.0000000000009166.
  • Hendijani, F., and V. Akbari. 2018. Probiotic supplementation for management of cardiovascular risk factors in adults with type II diabetes: A systematic review and meta-analysis. Clinical Nutrition (Edinburgh, Scotland) 37 (2):532–541. doi: 10.1016/j.clnu.2017.02.015.
  • Heshmati, J., F. Farsi, S. Yosaee, M. Razavi, M. Rezaeinejad, E. Karimie, and M. Sepidarkish. 2019. The effects of probiotics or synbiotics supplementation in women with polycystic ovarian syndrome: A systematic review and meta-analysis of randomized clinical trials. Probiotics and Antimicrobial Proteins 11 (4):1236–1247. doi: 10.1007/s12602-018-9493-9.
  • Higgins, J. P., D. G. Altman, P. C. Gøtzsche, P. Jüni, D. Moher, A. D. Oxman, J. Savović, K. F. Schulz, L. Weeks, and J. A. Sterne, Cochrane Bias Methods Group. 2011. The cochrane collaboration’s tool for assessing risk of bias in randomised trials. BMJ (Clinical Research ed.) 343 (oct18 2):d5928–d5928. doi: 10.1136/bmj.d5928.
  • Hu, Y. M., F. Zhou, Y. Yuan, and Y. C. Xu. 2017. Effects of probiotics supplement in patients with type 2 diabetes mellitus: A meta-analysis of randomized trials. Medicina Clínica (English Edition) 148 (8):362–370. doi: 10.1016/j.medcli.2016.11.036.
  • Huang, Y., and Y. Zheng. 2010. The probiotic Lactobacillus acidophilus reduces cholesterol absorption through the down-regulation of Niemann-Pick C1-like 1 in Caco-2 cells. The British Journal of Nutrition 103 (4):473–478. doi: 10.1017/S0007114509991991.
  • Jahangiri, A. 2010. High-density lipoprotein and the acute phase response. Current Opinion in Endocrinology, Diabetes, and Obesity 17 (2):156–160. doi: 10.1097/MED.0b013e328337278b.
  • Jellinger, P. S., D. A. Smith, A. E. Mehta, O. Ganda, Y. Handelsman, H. W. Rodbard, M. D. Shepherd, and J. A. Seibel, AACE Task Force for Management of Dyslipidemia and Prevention of Atherosclerosis. 2012. American Association of Clinical Endocrinologists’ Guidelines for management of dyslipidemia and prevention of atherosclerosis. Endocrine Practice: Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 18 Suppl 1:1–78. doi: 10.4158/ep.18.s1.1.
  • Jiang, J., C. Wu, C. Zhang, J. Zhao, L. Yu, H. Zhang, A. Narbad, W. Chen, and Q. Zhai. 2020. Effects of probiotic supplementation on cardiovascular risk factors in hypercholesterolemia: A systematic review and meta-analysis of randomized clinical trial. Journal of Functional Foods 74:104177. doi: 10.1016/j.jff.2020.104177.
  • Kasińska, M. A., and J. Drzewoski. 2015. Effectiveness of probiotics in type 2 diabetes: A meta-analysis. Polish Archives of Internal Medicine 125 (11):803–813. doi: 10.20452/pamw.3156.
  • Kocsis, T., B. Molnar, D. Nemeth, P. Hegyi, Z. Szakacs, A. Balint, A. Garami, A. Soos, K. Marta, and M. Solymar. 2020. Probiotics have beneficial metabolic effects in patients with type 2 diabetes mellitus: A meta-analysis of randomized clinical trials. Scientific Reports 10 (1):11787. doi: 10.1038/s41598-020-68440-1.
  • Kopin, L., and C. J. Lowenstein. 2017. Dyslipidemia. Annals of Internal Medicine 167 (11):ITC81–ITC96. doi: 10.7326/AITC201712050.
  • Last, A. R., J. D. Ference, and J. Falleroni. 2011. Pharmacologic treatment of hyperlipidemia. American Family Physician 84 (5):551–558.
  • Liang, T. T., L. Wu, Y. Xi, Y. Li, X. Q. Xie, C. C. Fan, L. S. Yang, S. H. Yang, X. F. Chen, J. M. Zhang, et al. 2021. Probiotics supplementation improves hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes mellitus: An update of meta-analysis. Critical Reviews in Food Science and Nutrition 61 (10):1670–1688. doi: 10.1080/10408398.2020.1764488.
  • Liang, X., Z. Zhang, X. Zhou, Y. Lu, R. Li, Z. Yu, L. Tong, P. Gong, H. Yi, T. Liu, et al. 2020. Probiotics improved hyperlipidemia in mice induced by a high cholesterol diet via downregulating FXR. Food & Function 11 (11):9903–9911. doi: 10.1039/d0fo02255a.
  • Li, C., X. Li, H. Han, H. Cui, M. Peng, G. Wang, and Z. Wang. 2016. Effect of probiotics on metabolic profiles in type 2 diabetes mellitus: A meta-analysis of randomized, controlled trials. Medicine 95 (26):e4088. doi: 10.1097/MD.0000000000004088.
  • Li, Y., Q. Ma, J. Wang, P. Li, L. Cheng, Y. An, Y. Duan, H. Dai, T. Wang, and B. Zhao. 2020. Relationship between hyperlipidemia and the gut microbiome of rats, characterized using high-throughput sequencing. Journal of Traditional Chinese Medical Sciences 7 (2):154–161. doi: 10.1016/j.jtcms.2020.04.006.
  • Lippi, G., and F. Sanchis-Gomar. 2020. An estimation of the worldwide epidemiologic burden of physical inactivity-related ischemic heart disease. Cardiovascular Drugs and Therapy 34 (1):133–5. doi: 10.1007/s10557-019-06926-5.
  • Li, H., R. Sun, Q. Chen, Q. Guo, J. Wang, L. Lu, and Y. Zhang. 2021. Association between HDL-C levels and menopause: A meta-analysis. Hormones (Athens, Greece) 20 (1):49–59. doi: 10.1007/s42000-020-00216-8.
  • Liu, Y., K. Chen, F. Li, Z. Gu, Q. Liu, L. He, T. Shao, Q. Song, F. Zhu, L. Zhang, et al. 2020. Probiotic Lactobacillus rhamnosus GG prevents liver fibrosis through inhibiting hepatic bile acid synthesis and enhancing bile acid excretion in mice. Hepatology (Baltimore, MD) 71 (6):2050–2066. doi: 10.1002/hep.30975.
  • Liu, L., P. Li, Y. Liu, and Y. Zhang. 2019. Efficacy of probiotics and synbiotics in patients with nonalcoholic fatty liver disease: A meta-analysis. Digestive Diseases and Sciences 64:3402–3412. doi: 10.1007/s10620-019-05699-z.
  • Lopez-Moreno, A., A. Suarez, C. Avanzi, M. Monteoliva-Sanchez, and M. Aguilera. 2020. Probiotic strains and intervention total doses for modulating obesity-related microbiota dysbiosis: A systematic review and meta-analysis. Nutrients 12 (7):1921. doi: 10.3390/nu1207.
  • Ma, Y. Y., L. Li, C. H. Yu, Z. Shen, L. H. Chen, and Y. M. Li. 2013. Effects of probiotics on nonalcoholic fatty liver disease: A meta-analysis. World Journal of Gastroenterology 19 (40):6911–6918. doi: 10.3748/wjg.v19.i40.6911.
  • Markowiak, P., and K. Śliżewska. 2017. Effects of probiotics, prebiotics, and synbiotics on human health. Nutrients 9 (9):1021. doi: 10.3390/nu9091021.
  • Mazloom, Z., A. Yousefinejad, and M. H. Dabbaghmanesh. 2013. Effect of probiotics on lipid profile, glycemic control, insulin action, oxidative stress, and inflammatory markers in patients with type 2 diabetes: A clinical trial. Iranian Journal of Medical Sciences 38 (1):38–43.
  • Merkel, M., B. Loeffler, M. Kluger, N. Fabig, G. Geppert, L. A. Pennacchio, A. Laatsch, and J. Heeren. 2005. Apolipoprotein AV accelerates plasma hydrolysis of triglyceride-rich lipoproteins by interaction with proteoglycan-bound lipoprotein lipase *. The Journal of Biological Chemistry 280 (22):21553–21560. doi: 10.1074/jbc.M411412200.
  • Mo, R., X. Zhang, and Y. Yang. 2019. Effect of probiotics on lipid profiles in hypercholesterolaemic adults: A meta-analysis of randomized controlled trials. Medicina Clinica 152 (12):473–481. doi: 10.1016/j.medcli.2018.09.007.
  • Moravejolahkami, A. R., M. A. H. Kermani, Z. B. Zehi, S. M. S. Mirenayat, and M. Mansourian. 2021. The effect of probiotics on lipid profile & anthropometric indices in diabetic nephropathy; a systematic review and meta-analysis of clinical trials. Journal of Diabetes and Metabolic Disorders 20 (1):893–12. doi: 10.1007/s40200-021-00765-8.
  • Pan, D. D., X. Q. Zeng, and Y. T. Yan. 2011. Characterisation of Lactobacillus fermentum SM‐7 isolated from koumiss, a potential probiotic bacterium with cholesterol‐lowering effects. Journal of the Science of Food and Agriculture 91 (3):512–518. doi: 10.1002/jsfa.4214.
  • Pourrajab, B., S. Fatahi, A. Dehnad, H. K. Varkaneh, and F. Shidfar. 2020. The impact of probiotic yogurt consumption on lipid profiles in subjects with mild to moderate hypercholesterolemia: A systematic review and meta-analysis of randomized controlled trials. Nutrition, Metabolism, and Cardiovascular Diseases: NMCD 30 (1):11–22. doi: 10.1016/j.numecd.2019.10.001.
  • Rajkumar, H., N. Mahmood, M. Kumar, S. R. Varikuti, H. R. Challa, and S. P. Myakala. 2014. Effect of probiotic (VSL#3) and omega-3 on lipid profile, insulin sensitivity, inflammatory markers, and gut colonization in overweight adults: A randomized, controlled trial. Mediators of Inflammation 2014:1–8. doi: 10.1155/2014/348959.
  • Razmpoosh, E., A. Javadi, H. S. Ejtahed, P. Mirmiran, M. Javadi, and A. Yousefinejad. 2019. The effect of probiotic supplementation on glycemic control and lipid profile in patients with type 2 diabetes: A randomized placebo controlled trial. Diabetes & Metabolic Syndrome 13 (1):175–182. doi: 10.1016/j.dsx.2018.08.008.
  • Reddy Kilim, S., and S. R. Chandala. 2013. A comparative study of lipid profile and oestradiol in pre- and post-menopausal women. Journal of Clinical and Diagnostic Research 7:1596–1598. doi: 10.7860/JCDR/2013/6162.3234.
  • Reis, S. A., L. L. Conceição, D. D. Rosa, N. P. Siqueira, and M. C. G. Peluzio. 2017. Mechanisms responsible for the hypocholesterolaemic effect of regular consumption of probiotics. Nutrition Research Reviews 30 (1):36–49. doi: 10.1017/S0954422416000226.
  • Ryan, J. J., D. A. Hanes, M. B. Schafer, J. Mikolai, and H. Zwickey. 2015. Effect of the Probiotic Saccharomyces boulardii on cholesterol and lipoprotein particles in hypercholesterolemic adults: A single-arm, open-label pilot study. Journal of Alternative and Complementary Medicine (New York, NY) 21 (5):288–293. doi: 10.1089/acm.2014.0063.
  • Salles, B. I. M., D. Cioffi, and S. R. G. Ferreira. 2020. Probiotics supplementation and insulin resistance: A systematic review. Diabetology & Metabolic Syndrome 12 (1):98. doi: 10.1186/s13098-020-00603-6.
  • Santas, J., E. Lázaro, and J. Cuñé. 2017. Effect of a polysaccharide‐rich hydrolysate from Saccharomyces cerevisiae (LipiGo®) in body weight loss: Randomised, double‐blind, placebo‐controlled clinical trial in overweight and obese adults. Journal of the Science of Food and Agriculture 97 (12):4250–4257. doi: 10.1002/jsfa.8301.
  • Sharma, S., A. V. Kurpad, and S. Puri. 2016. Potential of probiotics in hypercholesterolemia: A meta-analysis. Indian Journal of Public Health 60 (4):280–286. doi: 10.4103/0019-557X.195859.
  • Shea, B. J., J. M. Grimshaw, G. A. Wells, M. Boers, N. Andersson, C. Hamel, A. C. Porter, P. Tugwell, D. Moher, and L. M. Bouter. 2007. Development of AMSTAR: A measurement tool to assess the methodological quality of systematic reviews. BMC Medical Research Methodology 7:10–7. doi: 10.1186/1471-2288-7-10.
  • Shimizu, M., M. Hashiguchi, T. Shiga, H-o Tamura, and M. Mochizuki. 2015. Meta-analysis: Effects of probiotic supplementation on lipid profiles in normal to mildly hypercholesterolemic Individuals. PloS One 10 (10):e0139795. doi: 10.1371/journal.pone.0139795.
  • Sun, J., and N. Buys. 2015. Effects of probiotics consumption on lowering lipids and CVD risk factors: A systematic review and meta-analysis of randomized controlled trials. Annals of Medicine 47 (6):430–440. doi: 10.3109/07853890.2015.1071872.
  • Tamtaji, O. R., A. Milajerdi, Ž. Reiner, Z. Asemi, E. Dadgostar, R. Heidari-Soureshjani, P. Mamsharifi, E. Amirani, H. Mirzaei, J. Hallajzadeh, et al. 2020. A systematic review and meta-analysis: The effects of probiotic supplementation on metabolic profile in patients with neurological disorders. Complementary Therapies in Medicine 53:102507. doi: 10.1016/j.ctim.2020.102507.
  • Tang, Y., J. Huang, W. Y. Zhang, S. Qin, Y. X. Yang, H. Ren, Q-b Yang, and H. Hu. 2019. Effects of probiotics on nonalcoholic fatty liver disease: A systematic review and meta-analysis. Therapeutic Advances in Gastroenterology 12:1756284819878046. doi: 10.1177/1756284819878046.
  • Taylor, B. L., G. E. Woodfall, K. E. Sheedy, M. L. O’Riley, K. A. Rainbow, E. L. Bramwell, and N. J. Kellow. 2017. Effect of Probiotics on Metabolic Outcomes in Pregnant Women with Gestational Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients 9 (5):doi: 10.3390/nu9050461. 28475161
  • Tsai, C.-C., P.-P. Lin, Y.-M. Hsieh, Z-y Zhang, H.-C. Wu, and C.-C. Huang. 2014. Cholesterol-lowering potentials of lactic acid bacteria based on bile-salt hydrolase activity and effect of potent strains on cholesterol metabolism In Vitro and In Vivo. TheScientificWorldJournal 2014:690752. doi: 10.1155/2014/690752.
  • Wang, L., M.-J. Guo, Q. Gao, J.-F. Yang, L. Yang, X.-L. Pang, and X.-J. Jiang. 2018. The effects of probiotics on total cholesterol: A meta-analysis of randomized controlled trials. Medicine 97 (5):e9679. doi: 10.1097/MD.0000000000009679.
  • Wang, Z.-B., S.-S. Xin, L.-N. Ding, W.-Y. Ding, Y.-L. Hou, C.-Q. Liu, and X.-D. Zhang. 2019. The potential role of probiotics in controlling overweight/obesity and associated metabolic parameters in adults: A systematic review and meta-analysis. Evidence-Based Complementary and Alternative Medicine: eCAM 2019:3862971. doi: 10.1155/2019/3862971.
  • Wang, C., C. Zhang, S. Li, L. Yu, F. Tian, J. Zhao, H. Zhang, W. Chen, and Q. Zhai. 2020. Effects of probiotic supplementation on dyslipidemia in type 2 diabetes mellitus: A meta-analysis of randomized controlled trials. Foods 9 (11):1540. doi: 10.3390/foods9111540.
  • Wickström, C., L. C. de Paz, J. R. Davies, and G. Svensäter. 2013. Surface-associated MUC5B mucins promote protease activity in Lactobacillus fermentum biofilms. BMC Oral Health 13 (1):1–9. doi: 10.1186/1472-6831-13-43.
  • Wilson, P. W. F., R. B. D’Agostino, D. Levy, A. M. Belanger, H. Silbershatz, and W. B. Kannel. 1998. Prediction of coronary heart disease using risk factor categories. Circulation 97 (18):1837–1847. doi: 10.1161/01.CIR.97.18.1837.
  • Wu, Y., Q. Zhang, Y. Ren, and Z. Ruan. 2017. Effect of probiotic Lactobacillus on lipid profile: A systematic review and meta-analysis of randomized, controlled trials. PloS One 12 (6):e0178868. doi: 10.1371/journal.pone.0178868.
  • Xiao, M. W., S. X. Lin, Z. H. Shen, W. W. Luo, and X. Y. Wang. 2019. Systematic review with meta-analysis: The effects of probiotics in nonalcoholic fatty liver disease. Gastroenterology Research and Practice 2019:1484598. doi: 10.1155/2019/1484598.
  • Yan, S., Z. Tian, M. Li, B. Li, and W. Cui. 2019. Effects of probiotic supplementation on the regulation of blood lipid levels in overweight or obese subjects: A meta-analysis. Food Function 10 (3):1747–1759. doi: 10.1039/c8fo02163e.
  • Yao, K., L. Zeng, Q. He, W. Wang, J. Lei, and X. Zou. 2017. Effect of probiotics on glucose and lipid metabolism in type 2 diabetes mellitus: A meta-analysis of 12 randomized controlled trials. Medical Science Monitor 23:3044–3053. doi: 10.12659/MSM.902600.
  • Yonejima, Y., K. Ushida, and Y. Mori. 2013. Effect of lactic acid bacteria on lipid metabolism and fat synthesis in mice fed a high-fat diet. Bioscience of Microbiota, Food and Health 32 (2):51–58. doi: 10.12938/bmfh.32.51.
  • Zhang, Y.-J., S. Li, R.-Y. Gan, T. Zhou, D.-P. Xu, and H.-B. Li. 2015. Impacts of gut bacteria on human health and diseases. International Journal of Molecular Sciences 16 (4):7493–7519. doi: 10.3390/ijms16047493.
  • Zhang, J., S. Ma, S. Wu, C. Guo, S. Long, and H. Tan. 2019. Effects of probiotic supplement in pregnant women with gestational diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials. Journal of Diabetes Research 2019:5364730. doi: 10.1155/2019/5364730.
  • Ziaei, R., A. Ghavami, S. Khalesi, R. Ghiasvand, and A. Mokari_Yamchi. 2021. The effect of probiotic fermented milk products on blood lipid concentrations: A systematic review and meta-analysis of randomized controlled trials. Nutrition, Metabolism and Cardiovascular Diseases 31 (4):997–1015. doi: 10.1016/j.numecd.2020.12.023.

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