Efficacy of flavonoids on biomarkers of type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials

References

• Ahmed, N. 2005. Advanced glycation endproducts-role in pathology of diabetic complications. Diabetes Research and Clinical Practice 67 (1):3–21. doi:10.1016/j.diabres.2004.09.004.
   PubMed Web of Science ®Google Scholar
• Alnajjar, M., S. Kumar Barik, C. Bestwick, F. Campbell, M. Cruickshank, F. Farquharson, G. Holtrop, G. Horgan, P. Louis, K.-M. Moar, et al. 2020. Anthocyanin-enriched bilberry extract attenuates glycaemic response in overweight volunteers without changes in insulin. Journal of Functional Foods 64:103597. doi:10.1016/j.jff.2019.103597.
   Web of Science ®Google Scholar
• American Diabetes Association. 2014. Diagnosis and classification of diabetes mellitus. Diabetes Care 37 (Supplement 1):S81–S90.
   PubMed Web of Science ®Google Scholar
• American Diabetes Association. 2021. Classification and diagnosis of diabetes: Standards of medical care in diabetes—2021. Diabetes Care 44 (Supplement 1):S15. doi:10.2337/dc21-S002.
   PubMed Web of Science ®Google Scholar
• Asadi, A., F. Shidfar, M. Safari, A. F. Hosseini, H. F. Huseini, I. Heidari, and A. Rajab. 2019. Efficacy of Melissa officinalis L. (lemon balm) extract on glycemic control and cardiovascular risk factors in individuals with type 2 diabetes: A randomized, double-blind, clinical trial. Phytotherapy Research 33 (3):651–9. doi:10.1002/ptr.6254.
   PubMed Web of Science ®Google Scholar
• Avery, M. A., C. S. Mizuno, A. G. Chittiboyina, T. W. Kurtz, and H. A. Pershadsingh. 2008. Type 2 diabetes and oral antihyperglycemic drugs. Current Medicinal Chemistry 15 (1):61–74. doi:10.2174/092986708783330656.
   PubMed Web of Science ®Google Scholar
• Bahadoran, Z., P. Mirmiran, and F. Azizi. 2013. Dietary polyphenols as potential nutraceuticals in management of diabetes: A review. Journal of Diabetes and Metabolic Disorders 12 (1):43. doi:10.1186/2251-6581-12-43.
   PubMedGoogle Scholar
• Barnes, P. J., and I. M. Adcock. 1997. NF-kB: A pivotal role in asthma and a new target for therapy. Trends in Pharmacological Sciences 18 (2):46–50. doi:10.1016/S0165-6147(97)89796-9.
   PubMed Web of Science ®Google Scholar
• Bazzano, L. A., M. K. Serdula, and S. Liu. 2003. Dietary intake of fruits and vegetables and risk of cardiovascular disease. Current Atherosclerosis Reports 5 (6):492–9. doi:10.1007/s11883-003-0040-z.
   PubMedGoogle Scholar
• Borenstein, M., L. V. Hedges, J. P. Higgins, and H. R. Rothstein. 2021. Introduction to meta-analysis: Hoboken: Wiley.
   Google Scholar
• Borenstein, M., and J. P. Higgins. 2013. Meta-analysis and subgroups. Prevention Science : The Official Journal of the Society for Prevention Research 14 (2):134–43. doi:10.1007/s11121-013-0377-7.
   PubMed Web of Science ®Google Scholar
• Braxas, H., M. Rafraf, S. K. Hasanabad, and M. A. Jafarabadi. 2019. Effectiveness of genistein supplementation on metabolic factors and antioxidant status in postmenopausal women with type 2 diabetes mellitus. Canadian Journal of Diabetes 43 (7):490–7. doi:10.1016/j.jcjd.2019.04.007.
   PubMed Web of Science ®Google Scholar
• Cai, E. P., and J.-K. Lin. 2009. Epigallocatechin gallate (EGCG) and rutin suppress the glucotoxicity through activating IRS2 and AMPK signaling in rat pancreatic beta cells. Journal of Agricultural and Food Chemistry 57 (20):9817–27. doi:10.1021/jf902618v.
   PubMed Web of Science ®Google Scholar
• Carpene, C., S. Gomez-Zorita, S. Deleruyelle, and M. A. Carpene. 2015. Novel strategies for preventing diabetes and obesity complications with natural polyphenols. Current Medicinal Chemistry 22 (1):150–64. doi:10.2174/0929867321666140815124052.
   PubMed Web of Science ®Google Scholar
• Cassidy, A., B. Hanley, and R. M. Lamuela-Raventos. 2000. Isoflavones, lignans and stilbenes – origins, metabolism and potential importance to human health. Journal of the Science of Food and Agriculture 80 (7):1044–62. doi:10.1002/(sici)1097-0010(20000515)80:7 < 1044::Aid-jsfa586 > 3.0.Co;2-n.
   Web of Science ®Google Scholar
• Castañeda-Ovando, A., M. d L. Pacheco-Hernández, M. E. Páez-Hernández, J. A. Rodríguez, and C. A. Galán-Vidal. 2009. Chemical studies of anthocyanins: A review. Food Chemistry 113 (4):859–71. doi:10.1016/j.foodchem.2008.09.001.
   Web of Science ®Google Scholar
• Ceriello, A. 2005. Postprandial hyperglycemia and diabetes complications: is it time to treat?. Diabetes 54 (1):1–7. doi:10.2337/diabetes.54.1.1.
   PubMed Web of Science ®Google Scholar
• Cernea, S., and M. Dobreanu. 2013. Diabetes and beta cell function: From mechanisms to evaluation and clinical implications. Biochemia Medica 23 (3):266–80. doi:10.11613/bm.2013.033.
   PubMed Web of Science ®Google Scholar
• Chatterjee, S., K. Khunti, and M. J. Davies. 2017. Type 2 diabetes. The Lancet 389 (10085):2239–51. doi:10.1016/S0140-6736(17)30058-2.
   PubMed Web of Science ®Google Scholar
• Choquette, S., É. Riesco, É. Cormier, T. Dion, M. Aubertin-Leheudre, and I. J. Dionne. 2011. Effects of soya isoflavones and exercise on body composition and clinical risk factors of cardiovascular diseases in overweight postmenopausal women: A 6-month double-blind controlled trial. British Journal of Nutrition 105 (8):1199–209. doi:10.1017/S0007114510004897.
   PubMed Web of Science ®Google Scholar
• Consortium, InterAct. 2012. Tea consumption and incidence of type 2 diabetes in Europe: The EPIC-InterAct case-cohort study. PLOS One. 7 (5):e36910.
   PubMed Web of Science ®Google Scholar
• Coskun, O., M. Kanter, A. Korkmaz, and S. Oter. 2005. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and β-cell damage in rat pancreas. Pharmacological Research 51 (2):117–23. doi:10.1016/j.phrs.2004.06.002.
   PubMed Web of Science ®Google Scholar
• Curtis, P. J., M. Sampson, J. Potter, K. Dhatariya, P. A. Kroon, and A. Cassidy. 2012. Chronic ingestion of flavan-3-ols and isoflavones improves insulin sensitivity and lipoprotein status and attenuates estimated 10-year CVD risk in medicated postmenopausal women with type 2 diabetes: A 1-year, double-blind, randomized, controlled trial. Diabetes Care 35 (2):226–32. doi:10.2337/dc11-1443.
   PubMed Web of Science ®Google Scholar
• Daisy, P., K. Balasubramanian, M. Rajalakshmi, J. Eliza, and J. Selvaraj. 2010. Insulin mimetic impact of catechin isolated from Cassia fistula on the glucose oxidation and molecular mechanisms of glucose uptake on Streptozotocin-induced diabetic Wistar rats. Phytomedicine 17 (1):28–36. doi:10.1016/j.phymed.2009.10.018.
   PubMed Web of Science ®Google Scholar
• de Andrade Teles, R. B., T. C. Diniz, T. C. Costa Pinto, R. G. de Oliveira Júnior, M. Gama e Silva, É. M. de Lavor, A. W. C. Fernandes, A. P. de Oliveira, F. P. R. de Almeida Ribeiro, A. A. M. da Silva, et al. 2018. Flavonoids as therapeutic agents in Alzheimer’s and Parkinson’s diseases: A systematic review of preclinical evidences. Oxidative Medicine and Cellular Longevity 2018:1–21. doi:10.1155/2018/7043213.
   Web of Science ®Google Scholar
• Del Bo, C., S. Bernardi, M. Marino, M. Porrini, M. Tucci, S. Guglielmetti, A. Cherubini, et al. 2019. Systematic review on polyphenol intake and health outcomes: Is there sufficient evidence to define a health-promoting polyphenol-rich dietary pattern? Nutrients 11 (6):1355. doi:10.3390/nu11061355.
   PubMed Web of Science ®Google Scholar
• DerSimonian, R., and N. Laird. 1986. Meta-analysis in clinical trials. Controlled Clinical Trials 7 (3):177–88. doi:10.1016/0197-2456(86)90046-2.
   PubMedGoogle Scholar
• Desideri, G., C. Kwik-Uribe, D. Grassi, S. Necozione, L. Ghiadoni, D. Mastroiacovo, A. Raffaele, L. Ferri, R. Bocale, M. C. Lechiara, et al. 2012. Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment. Hypertension 60 (3):794–801. doi:10.1161/HYPERTENSIONAHA.112.193060.
   PubMed Web of Science ®Google Scholar
• Dhanya, R., A. D. Arya, P. Nisha, and P. Jayamurthy. 2017. Quercetin, a lead compound against type 2 diabetes ameliorates glucose uptake via AMPK pathway in skeletal muscle cell line. Frontiers in Pharmacology 8:336. doi:10.3389/fphar.2017.00336.
   PubMed Web of Science ®Google Scholar
• Dias, T. R., M. G. Alves, S. Casal, P. F. Oliveira, and B. M. Silva. 2017. Promising potential of dietary (poly)phenolic compounds in the prevention and treatment of diabetes mellitus. Current Medicinal Chemistry 24 (4):334–54. doi:10.2174/0929867323666160905150419.
   PubMed Web of Science ®Google Scholar
• Dicks, L., N. Kirch, D. Gronwald, K. Wernken, B. F. Zimmermann, H.-P. Helfrich, and S. Ellinger. 2018. Regular intake of a usual serving size of flavanol-rich cocoa powder does not affect cardiometabolic parameters in stably treated patients with type 2 diabetes and hypertension—A Double-Blinded, Randomized, Placebo-Controlled Trial. Nutrients 10 (10):1435. doi:10.3390/nu10101435.
   PubMed Web of Science ®Google Scholar
• Duval, S., and R. Tweedie. 2000. Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 56 (2):455–63. doi:10.1111/j.0006-341x.2000.00455.x.
   PubMed Web of Science ®Google Scholar
• Egger, M., G. D. Smith, M. Schneider, and C. Minder. 1997. Bias in meta-analysis detected by a simple, graphical test. BMJ (Clinical Research ed.) 315 (7109):629–34. doi:10.1136/bmj.315.7109.629.
   PubMed Web of Science ®Google Scholar
• Einarson, T. R., A. Acs, C. Ludwig, and U. H. Panton. 2018. Prevalence of cardiovascular disease in type 2 diabetes: A systematic literature review of scientific evidence from across the world in 2007–2017. Cardiovascular Diabetology 17 (1):1–19. doi:10.1186/s12933-018-0728-6.
   PubMed Web of Science ®Google Scholar
• Fallah, A. A., E. Sarmast, P. Fatehi, and T. Jafari. 2020. Impact of dietary anthocyanins on systemic and vascular inflammation: Systematic review and meta-analysis on randomised clinical trials. Food and Chemical Toxicology 135:110922. doi:10.1016/j.fct.2019.110922.
   PubMed Web of Science ®Google Scholar
• Fallah, A. A., E. Sarmast, and T. Jafari. 2020. Effect of dietary anthocyanins on biomarkers of glycemic control and glucose metabolism: A systematic review and meta-analysis of randomized clinical trials. Food Research International 137:109379. doi:10.1016/j.foodres.2020.109379.
   PubMed Web of Science ®Google Scholar
• Feliciano, R. P., S. Pritzel, C. Heiss, and A. Rodriguez-Mateos. 2015. Flavonoid intake and cardiovascular disease risk. Current Opinion in Food Science 2:92–9. doi:10.1016/j.cofs.2015.02.006.
   Web of Science ®Google Scholar
• Fu, Z., and D. Liu. 2009. Long-term exposure to genistein improves insulin secretory function of pancreatic beta-cells. European Journal of Pharmacology 616 (1–3):321–7. doi:10.1016/j.ejphar.2009.06.005.
   PubMed Web of Science ®Google Scholar
• Gandhi, G. R., A. B. Vasconcelos, D.-T. Wu, H.-B. Li, P. J. Antony, H. Li, F. Geng, R. Q. Gurgel, N. Narain, and R.-Y. Gan. 2020. Citrus flavonoids as promising phytochemicals targeting diabetes and related complications: A systematic review of in vitro and in vivo studies. Nutrients 12 (10):2907. doi:10.3390/nu12102907.
   PubMed Web of Science ®Google Scholar
• Ghosh, H. S., M. McBurney, and P. D. Robbins. 2010. SIRT1 negatively regulates the mammalian target of rapamycin. Plos ONE 5 (2):e9199. doi:10.1371/journal.pone.0009199.
   PubMed Web of Science ®Google Scholar
• Gin, H., and V. Rigalleau. 2000. Post-prandial hyperglycemia. Post-prandial hyperglycemia and diabetes. Diabetes & Metabolism 26 (4):265–72.
   PubMed Web of Science ®Google Scholar
• Glisic, M., N. Kastrati, V. Gonzalez-Jaramillo, W. M. Bramer, F. Ahmadizar, R. Chowdhury, A. J. Danser, A. J. Roks, T. Voortman, O. H. Franco, et al. 2018. Associations between phytoestrogens, glucose homeostasis, and risk of diabetes in women: A systematic review and meta-analysis. Advances in Nutrition 9 (6):726–40. doi:10.1093/advances/nmy048.
   PubMed Web of Science ®Google Scholar
• Grosso, G., J. Godos, R. Lamuela-Raventos, S. Ray, A. Micek, A. Pajak, S. Sciacca, N. D’Orazio, D. Del Rio, and F. Galvano. 2017. A comprehensive meta-analysis on dietary flavonoid and lignan intake and cancer risk: Level of evidence and limitations. Molecular Nutrition & Food Research 61 (4):1600930. doi:10.1002/mnfr.201600930.
   Web of Science ®Google Scholar
• Guo, X., Y. Ruan, Z. Li, and D. Li. 2019. Flavonoid subclasses and type 2 diabetes mellitus risk: A meta-analysis of prospective cohort studies. Critical Reviews in Food Science and Nutrition 59 (17):2850–62. doi:10.1080/10408398.2018.1476964.
   PubMed Web of Science ®Google Scholar
• Guo, Y., P. Zhang, Y. Liu, L. Zha, W. Ling, and H. Guo. 2020. A dose-response evaluation of purified anthocyanins on inflammatory and oxidative biomarkers and metabolic risk factors in healthy young adults: A randomized controlled trial. Nutrition (Burbank, Los Angeles County, Calif.) 74:110745. doi:10.1016/j.nut.2020.110745.
   PubMed Web of Science ®Google Scholar
• Hall, W. L., K. Vafeiadou, J. Hallund, S. Bugel, M. Reimann, C. Koebnick, H.-J F. Zunft, M. Ferrari, F. Branca, T. Dadd, et al. 2006. Soy-isoflavone-enriched foods and markers of lipid and glucose metabolism in postmenopausal women: Interactions with genotype and equol production. The American Journal of Clinical Nutrition 83 (3):592–600. doi:10.1093/ajcn.83.3.592.
   PubMed Web of Science ®Google Scholar
• Harrer, M., P. Cuijpers, T. A. Furukawa, and D. D. Ebert. 2019. Doing meta-analysis in R: A hands-on guide. PROTECT Lab Erlangen.
   Google Scholar
• Higgins, J. P. T., D. G. Altman, P. C. Gøtzsche, P. Jüni, D. Moher, A. D. Oxman, J. Savović, K. F. Schulz, L. Weeks, and J. A. C. Sterne. 2011. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ (Clinical Research ed.) 343:d5928. doi:10.1136/bmj.d5928.
   PubMed Web of Science ®Google Scholar
• Higgins, J. P. T., and S. G. Thompson. 2003. Controlling the risk of spurious findings from meta-regression. Statistics in Medicine 23(11):1663–82.
   Web of Science ®Google Scholar
• Higgins, J. P., and S. G. Thompson. 2002. Quantifying heterogeneity in a meta-analysis. Statistics in Medicine 21 (11):1539–58. doi:10.1002/sim.1186.
   PubMed Web of Science ®Google Scholar
• Higgins, J. P., S. G. Thompson, J. J. Deeks, and D. G. Altman. 2003. Measuring inconsistency in meta-analyses. BMJ (Clinical Research ed.) 327 (7414):557–60. doi:10.1136/bmj.327.7414.557.
   PubMed Web of Science ®Google Scholar
• Hira, T., A. Trakooncharoenvit, H. Taguchi, and H. Hara. 2021. Improvement of glucose tolerance by food factors having glucagon-like peptide-1 releasing activity. International Journal of Molecular Sciences 22 (12):6623. doi:10.3390/ijms22126623.
   PubMed Web of Science ®Google Scholar
• Hlebowicz, J., A. Hlebowicz, S. Lindstedt, O. Björgell, P. Höglund, J. J. Holst, G. Darwiche, and L.-O. Almer. 2009. Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and ghrelin concentrations in healthy subjects. The American Journal of Clinical Nutrition 89 (3):815–21. doi:10.3945/ajcn.2008.26807.
   PubMed Web of Science ®Google Scholar
• Ho, S. C., Y-m Chen, S. S. S. Ho, and J. L. Woo. 2007. Soy isoflavone supplementation and fasting serum glucose and lipid profile among postmenopausal Chinese women: A double-blind, randomized, placebo-controlled trial. Menopause (New York, N.Y.) 14 (5):905–12. doi:10.1097/GME.0b013e318032b2d3.
   PubMed Web of Science ®Google Scholar
• International Diabetes Federation. 2019. Diabetes Atlas 9th edition 2019. https://www.diabetesatlas.org/en/.
   Google Scholar
• Jamilian, M., and Z. Asemi. 2016. The effects of soy isoflavones on metabolic status of patients with polycystic ovary syndrome. The Journal of Clinical Endocrinology & Metabolism 101 (9):3386–94. doi:10.1210/jc.2016-1762.
   PubMed Web of Science ®Google Scholar
• Janeček, Š., B. Svensson, and E. A. MacGregor. 2014. α-Amylase: An enzyme specificity found in various families of glycoside hydrolases. Cellular and Molecular Life Sciences 71 (7):1149–70. doi:10.1007/s00018-013-1388-z.
   PubMed Web of Science ®Google Scholar
• Jayagopal, V., P. Albertazzi, E. S. Kilpatrick, E. M. Howarth, P. E. Jennings, D. A. Hepburn, and S. L. Atkin. 2002. Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes. Diabetes Care 25 (10):1709–14. doi:10.2337/diacare.25.10.1709.
   PubMed Web of Science ®Google Scholar
• Jorge, A. P., H. Horst, E. d Sousa, M. G. Pizzolatti, and F. R. M. B. Silva. 2004. Insulinomimetic effects of kaempferitrin on glycaemia and on 14C-glucose uptake in rat soleus muscle. Chemico-Biological Interactions 149 (2–3):89–96. doi:10.1016/j.cbi.2004.07.001.
   PubMed Web of Science ®Google Scholar
• Khorshidi, M., A. Moini, E. Alipoor, N. Rezvan, S. Gorgani-Firuzjaee, M. Yaseri, and M. J. Hosseinzadeh-Attar. 2018. The effects of quercetin supplementation on metabolic and hormonal parameters as well as plasma concentration and gene expression of resistin in overweight or obese women with polycystic ovary syndrome. Phytotherapy Research 32 (11):2282–9. doi:10.1002/ptr.6166.
   PubMed Web of Science ®Google Scholar
• Kianbakht, S., B. Abasi, and F. Hashem Dabaghian. 2013. Anti-hyperglycemic effect of vaccinium arctostaphylos in type 2 diabetic patients: A Randomized Controlled Trial. Forschende Komplementärmedizin / Research in Complementary Medicine 20 (1):17–22. doi:10.1159/000346607.
   Google Scholar
• Kieffer, T. J., and J. Francis Habener. 1999. The glucagon-like peptides. Endocrine Reviews 20 (6):876–913. doi:10.1210/edrv.20.6.0385.
   PubMed Web of Science ®Google Scholar
• Kim, H., S. Y. Simbo, C. Fang, L. McAlister, A. Roque, N. Banerjee, S. T. Talcott, H. Zhao, R. B. Kreider, and S. U. Mertens-Talcott. 2018. Açaí (Euterpe oleracea Mart.) beverage consumption improves biomarkers for inflammation but not glucose- or lipid-metabolism in individuals with metabolic syndrome in a randomized, double-blinded, placebo-controlled clinical trial. Food & Function 9 (6):3097–103. doi:10.1039/c8fo00595h.
   PubMed Web of Science ®Google Scholar
• Kobayashi, Y., M. Suzuki, H. Satsu, S. Arai, Y. Hara, K. Suzuki, Y. Miyamoto, and M. Shimizu. 2000. Green tea polyphenols inhibit the sodium-dependent glucose transporter of intestinal epithelial cells by a competitive mechanism. Journal of Agricultural and Food Chemistry 48 (11):5618–23. doi:10.1021/jf0006832.
   PubMed Web of Science ®Google Scholar
• Kwon, O., P. Eck, S. Chen, C. P. Corpe, J. ‐H. Lee, M. Kruhlak, and M. Levine. 2007. Inhibition of the intestinal glucose transporter GLUT2 by flavonoids. FASEB Journal 21 (2):366–77. doi:10.1096/fj.06-6620com.
   PubMed Web of Science ®Google Scholar
• Lacroix, I. M., and E. C. Li-Chan. 2014. Overview of food products and dietary constituents with antidiabetic properties and their putative mechanisms of action: A natural approach to complement pharmacotherapy in the management of diabetes. Molecular Nutrition & Food Research 58 (1):61–78. doi:10.1002/mnfr.201300223.
   PubMed Web of Science ®Google Scholar
• Levin, F., T. Edholm, P. T. Schmidt, P. GrybäCk, H. Jacobsson, M. Degerblad, C. HöYbye, J. J. Holst, J. F. Rehfeld, P. M. HellströM, et al. 2006. Ghrelin stimulates gastric emptying and hunger in normal-weight humans. The Journal of Clinical Endocrinology & Metabolism 91 (9):3296–302. doi:10.1210/jc.2005-2638.
   PubMed Web of Science ®Google Scholar
• Lillioja, S., D. M. Mott, B. V. Howard, P. H. Bennett, H. Yki-Järvinen, D. Freymond, B. L. Nyomba, F. Zurlo, B. Swinburn, and C. Bogardus. 1988. Impaired glucose tolerance as a disorder of insulin action. Longitudinal and cross-sectional studies in Pima Indians. The New England Journal of Medicine 318 (19):1217–25. doi:10.1056/NEJM198805123181901.
   PubMed Web of Science ®Google Scholar
• Lin, X., I. Zhang, A. Li, J. E. Manson, H. D. Sesso, L. Wang, and S. Liu. 2016. Cocoa flavanol intake and biomarkers for cardiometabolic health: A systematic review and meta-analysis of randomized controlled trials. The Journal of Nutrition 146 (11):2325–33. doi:10.3945/jn.116.237644.
   PubMed Web of Science ®Google Scholar
• Liu, Z-m, Y-m Chen, S. C. Ho, Y. P. Ho, and J. Woo. 2010. Effects of soy protein and isoflavones on glycemic control and insulin sensitivity: A 6-mo double-blind, randomized, placebo-controlled trial in postmenopausal Chinese women with prediabetes or untreated early diabetes. The American Journal of Clinical Nutrition 91 (5):1394–401. doi:10.3945/ajcn.2009.28813.
   PubMed Web of Science ®Google Scholar
• Liu, Y.-J., J. Zhan, X.-L. Liu, Y. Wang, J. Ji, and Q.-Q. He. 2014. Dietary flavonoids intake and risk of type 2 diabetes: A meta-analysis of prospective cohort studies. Clinical Nutrition (Edinburgh, Scotland) 33 (1):59–63. doi:10.1016/j.clnu.2013.03.011.
   PubMed Web of Science ®Google Scholar
• Li, D., Y. Zhang, Y. Liu, R. Sun, and M. Xia. 2015. Purified anthocyanin supplementation reduces dyslipidemia, enhances antioxidant capacity, and prevents insulin resistance in diabetic patients. The Journal of Nutrition 145 (4):742–8. doi:10.3945/jn.114.205674.
   PubMed Web of Science ®Google Scholar
• Li, Y. Q., F. C. Zhou, F. Gao, J. S. Bian, and F. Shan. 2009. Comparative evaluation of quercetin, isoquercetin and rutin as inhibitors of alpha-glucosidase. Journal of Agricultural and Food Chemistry 57 (24):11463–8. doi:10.1021/jf903083h.
   PubMed Web of Science ®Google Scholar
• Llaneza, P., C. González, J. Fernández-Iñarrea, A. Alonso, F. Díaz, and F. R. Pérez-López. 2012. Soy isoflavones improve insulin sensitivity without changing serum leptin among postmenopausal women. Climacteric: The Journal of the International Menopause Society 15 (6):611–20. doi:10.3109/13697137.2011.631062.
   PubMed Web of Science ®Google Scholar
• Lochhead, P. A., M. Coghlan, S. Q. Rice, and C. Sutherland. 2001. Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolypyruvate carboxykinase gene expression. Diabetes 50 (5):937–46. doi:10.2337/diabetes.50.5.937.
   PubMed Web of Science ®Google Scholar
• Manach, C., A. Scalbert, C. Morand, C. Rémésy, and L. Jiménez. 2004. Polyphenols: Food sources and bioavailability. The American Journal of Clinical Nutrition 79 (5):727–47. doi:10.1093/ajcn/79.5.727.
   PubMed Web of Science ®Google Scholar
• Marini, H., A. Bitto, D. Altavilla, B. P. Burnett, F. Polito, V. Di Stefano, L. Minutoli, M. Atteritano, R. M. Levy, N. Frisina, et al. 2010. Efficacy of genistein aglycone on some cardiovascular risk factors and homocysteine levels: A follow-up study. Nutrition, Metabolism, and Cardiovascular Diseases 20 (5):332–40. doi:10.1016/j.numecd.2009.04.012.
   PubMed Web of Science ®Google Scholar
• Marnett, L. J., S. W. Rowlinson, D. C. Goodwin, A. S. Kalgutkar, and C. A. Lanzo. 1999. Arachidonic acid oxygenation by COX-1 and COX-2 Mechanisms of catalysis and inhibition. The Journal of Biological Chemistry 274 (33):22903–6. doi:10.1074/jbc.274.33.22903.
   PubMed Web of Science ®Google Scholar
• Matthews, D. R., J. P. Hosker, A. S. Rudenski, B. A. Naylor, D. F. Treacher, and R. C. Turner. 1985. Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28 (7):412–9. doi:10.1007/BF00280883.
   PubMed Web of Science ®Google Scholar
• Mc Auley, M. T., and K. M. Mooney. 2014. Lipid metabolism and hormonal interactions: Impact on cardiovascular disease and healthy aging. Expert Review of Endocrinology & Metabolism 9 (4):357–67. doi:10.1586/17446651.2014.921569.
   PubMedGoogle Scholar
• McCullough, M. L., J. J. Peterson, R. Patel, P. F. Jacques, R. Shah, and J. T. Dwyer. 2012. Flavonoid intake and cardiovascular disease mortality in a prospective cohort of US adults. The American Journal of Clinical Nutrition 95 (2):454–64. doi:10.3945/ajcn.111.016634.
   PubMed Web of Science ®Google Scholar
• Menezes, R., A. Rodriguez-Mateos, A. Kaltsatou, A. González-Sarrías, A. Greyling, C. Giannaki, C. Andres-Lacueva, D. Milenkovic, E. Gibney, J. Dumont, et al. 2017. Impact of flavonols on cardiometabolic biomarkers: A meta‐analysis of randomized controlled human trials to explore the role of inter‐individual variability. Nutrients 9 (2):117. doi:10.3390/nu9020117.
   PubMed Web of Science ®Google Scholar
• Michalak, A. 2006. Phenolic compounds and their antioxidant activity in plants growing under heavy metal stress. Polish Journal of Environmental Studies 15 (4):523–530.
   Web of Science ®Google Scholar
• Minokoshi, Y., C. R. Kahn, and B. B. Kahn. 2003. Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis. The Journal of Biological Chemistry 278 (36):33609–12. doi:10.1074/jbc.R300019200.
   PubMed Web of Science ®Google Scholar
• Moher, D., A. Liberati, J. Tetzlaff, and D. G. Altman and Prisma Group. 2009. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Medicine 6 (7):e1000097. doi:10.1371/journal.pmed.1000097.
   PubMed Web of Science ®Google Scholar
• Mukamal, K. J., K. MacDermott, J. A. Vinson, N. Oyama, W. J. Manning, and M. A. Mittleman. 2007. A 6-month randomized pilot study of black tea and cardiovascular risk factors. American Heart Journal 154 (4):724.e1–724.e6. doi:10.1016/j.ahj.2007.07.008.
   PubMed Web of Science ®Google Scholar
• Mulvihill, E. E., and M. W. Huff. 2010. Antiatherogenic properties of flavonoids: Implications for cardiovascular health. Canadian Journal of Cardiology 26:17A–21A. doi:10.1016/S0828-282X(10)71056-4.
   PubMed Web of Science ®Google Scholar
• Muniyappa, R., G. Hall, T. L. Kolodziej, R. J. Karne, S. K. Crandon, and M. J. Quon. 2008. Cocoa consumption for 2 wk enhances insulin-mediated vasodilatation without improving blood pressure or insulin resistance in essential hypertension. The American Journal of Clinical Nutrition 88 (6):1685–96. doi:10.3945/ajcn.2008.26457.
   PubMed Web of Science ®Google Scholar
• Nathan, D. M., B. Balkau, E. Bonora, K. Borch-Johnsen, J. B. Buse, S. Colagiuri, M. B. Davidson, R. DeFronzo, S. Genuth, and R. R. Holman. 2010. International expert committee report on the role of the A1C assay in the diagnosis of diabetes. CPD Bulletin Clinical Biochemistry 10 (1):25–33.
   Google Scholar
• Pessin, J. E., and A. R. Saltiel. 2000. Signaling pathways in insulin action: Molecular targets of insulin resistance. The Journal of Clinical Investigation 106 (2):165–9. doi:10.1172/JCI10582.
   PubMed Web of Science ®Google Scholar
• Pietta, P., M. Minoggio, and L. Bramati. 2003. Plant polyphenols: Structure, occurrence and bioactivity. Studies in Natural Products Chemistry, 28, 257–312.
   Google Scholar
• Proença, C., M. Freitas, D. Ribeiro, E. F. Oliveira, J. L. Sousa, S. M. Tomé, M. J. Ramos, A. M. Silva, P. A. Fernandes, and E. Fernandes. 2017. α-Glucosidase inhibition by flavonoids: An in vitro and in silico structure-activity relationship study. Journal of Enzyme Inhibition and Medicinal Chemistry 32 (1):1216–28. doi:10.1080/14756366.2017.1368503.
   PubMed Web of Science ®Google Scholar
• Radziuk, J. 2000. Insulin sensitivity and its measurement: Structural commonalities among the methods. The Journal of Clinical Endocrinology and Metabolism 85 (12):4426–33. doi:10.1210/jc.85.12.4426.
   PubMed Web of Science ®Google Scholar
• Raimundo, A. F., F. Félix, R. Andrade, M.-T. García-Conesa, A. González-Sarrías, J. Gilsa-Lopes, A. Raimundo, R. Ribeiro, A. Rodriguez-Mateos, and C. N. Santos. 2020. Combined effect of interventions with pure or enriched mixtures of (poly)phenols and anti-diabetic medication in type 2 diabetes management: A meta-analysis of randomized controlled human trials. European Journal of Nutrition 59 (4):1329–43. doi:10.1007/s00394-020-02189-1.
   PubMed Web of Science ®Google Scholar
• RcoreTeam. 2020. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing.
   Google Scholar
• Rocha, D. M. U. P, A. P. S. Caldas, B. Pereira da Silva, H. H. M. Hermsdorff, and R. d. C. G. Alfenas. 2019. Effects of blueberry and cranberry consumption on type 2 diabetes glycemic control: A systematic review. Critical Reviews in Food Science and Nutrition 59 (11):1816–28. doi:10.1080/10408398.2018.1430019.
   PubMed Web of Science ®Google Scholar
• Rohlfing, C. L., H.-M. Wiedmeyer, R. R. Little, J. D. England, A. Tennill, and D. E. Goldstein. 2002. Defining the relationship between plasma glucose and HbA(1c): analysis of glucose profiles and HbA(1c) in the Diabetes Control and Complications Trial. Diabetes Care 25 (2):275–8. doi:10.2337/diacare.25.2.275.
   PubMed Web of Science ®Google Scholar
• Rouse, M., A. Younès, and J. M. Egan. 2014. Resveratrol and curcumin enhance pancreatic β-cell function by inhibiting phosphodiesterase activity. The Journal of Endocrinology 223 (2):107–17. doi:10.1530/JOE-14-0335.
   PubMed Web of Science ®Google Scholar
• Saeedi, P., I. Petersohn, P. Salpea, B. Malanda, S. Karuranga, N. Unwin, S. Colagiuri, L. Guariguata, A. A. Motala, K. Ogurtsova, et al. 2019. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Research and Clinical Practice 157:107843. doi:10.1016/j.diabres.2019.107843.
   PubMed Web of Science ®Google Scholar
• Saltiel, A. R., and C. R. Kahn. 2001. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414 (6865):799–806. doi:10.1038/414799a.
   PubMed Web of Science ®Google Scholar
• Scalbert, A., C. Manach, C. Morand, C. Rémésy, and L. Jiménez. 2005. Dietary polyphenols and the prevention of diseases. Critical Reviews in Food Science and Nutrition 45 (4):287–306. doi:10.1080/1040869059096.
   PubMed Web of Science ®Google Scholar
• Scheepers, A., H.-G. Joost, and A. Schurmann. 2004. The glucose transporter families SGLT and GLUT: Molecular basis of normal and aberrant function. Journal of Parenteral and Enteral Nutrition 28 (5):364–71. doi:10.1177/0148607104028005364.
   PubMed Web of Science ®Google Scholar
• Schell, J., N. M. Betts, T. J. Lyons, and A. Basu. 2019. Raspberries improve postprandial glucose and acute and chronic inflammation in adults with type 2 diabetes. Annals of Nutrition and Metabolism 74 (2):165–74. doi:10.1159/000497226.
   PubMed Web of Science ®Google Scholar
• Singh, R., A. Barden, T. Mori, and L. Beilin. 2001. Advanced glycation end-products: A review. Diabetologia 44 (2):129–46. doi:10.1007/s001250051591.
   PubMed Web of Science ®Google Scholar
• Singh, B., and A. Saxena. 2010. Surrogate markers of insulin resistance: A review. World Journal of Diabetes 1 (2):36–47. doi:10.4239/wjd.v1.i2.36.
   PubMedGoogle Scholar
• Sites, C. K., B. C. Cooper, M. J. Toth, A. Gastaldelli, A. Arabshahi, and S. Barnes. 2007. Effect of a daily supplement of soy protein on body composition and insulin secretion in postmenopausal women. Fertility and Sterility 88 (6):1609–17. doi:10.1016/j.fertnstert.2007.01.061.
   PubMed Web of Science ®Google Scholar
• Solayman, M., Y. Ali, F. Alam, A. Islam, N. Alam, I. Khalil, and S. H. Gan. 2016. Polyphenols: Potential future arsenals in the treatment of diabetes. Current Pharmaceutical Design 22 (5):549–65. doi:10.2174/1381612822666151125001111.
   PubMed Web of Science ®Google Scholar
• Soltani, R., A. Gorji, S. Asgary, N. Sarrafzadegan, and M. Siavash. 2015. Evaluation of the effects of Cornus mas L. fruit extract on glycemic control and insulin level in type 2 diabetic adult patients: A Randomized Double-Blind Placebo-Controlled Clinical Trial. Evidence-Based Complementary and Alternative Medicine 2015:1–5. doi:10.1155/2015/740954.
   Google Scholar
• Song, Y., J. E. Manson, L. Tinker, B. V. Howard, L. H. Kuller, L. Nathan, N. Rifai, and S. Liu. 2007. Insulin sensitivity and insulin secretion determined by homeostasis model assessment and risk of diabetes in a multiethnic cohort of women: The Women’s Health Initiative Observational Study. Diabetes Care 30 (7):1747–52. doi:10.2337/dc07-0358.
   PubMed Web of Science ®Google Scholar
• Squadrito, F., H. Marini, A. Bitto, D. Altavilla, F. Polito, E. B. Adamo, R. D’Anna, V. Arcoraci, B. P. Burnett, L. Minutoli, et al. 2013. Genistein in the metabolic syndrome: Results of a randomized clinical trial. The Journal of Clinical Endocrinology & Metabolism 98 (8):3366–74. doi:10.1210/jc.2013-1180.
   PubMed Web of Science ®Google Scholar
• Stote, K. S., M. M. Wilson, D. Hallenbeck, K. Thomas, J. M. Rourke, M. I. Sweeney, K. T. Gottschall-Pass, and A. R. Gosmanov. 2020. Effect of blueberry consumption on cardiometabolic health parameters in men with type 2 diabetes: An 8-week, double-blind, randomized, placebo-controlled trial. Current Developments in Nutrition 4 (4):nzaa030. doi:10.1093/cdn/nzaa030.
   PubMed Web of Science ®Google Scholar
• Sudhir, R., and V. Mohan. 2002. Postprandial hyperglycemia in patients with type 2 diabetes mellitus. Treatments in Endocrinology 1 (2):105–16. doi:10.2165/00024677-200201020-00004.
   PubMedGoogle Scholar
• Sung, K.-C., G. M. Reaven, and S. H. Kim. 2010. Utility of homeostasis model assessment of beta-cell function in predicting diabetes in 12,924 healthy Koreans. Diabetes Care 33 (1):200–2. doi:10.2337/dc09-1070.
   PubMed Web of Science ®Google Scholar
• Syed, D. N., V. M. Adhami, M. I. Khan, and H. Mukhtar. 2013. Inhibition of Akt/mTOR signaling by the dietary flavonoid fisetin. Anti-Cancer Agents in Medicinal Chemistry 13 (7):995–1001. doi:10.2174/18715206113139990129.
   PubMed Web of Science ®Google Scholar
• The Cochrane Collaboration. 2020. Review Manager (RevMan) Version 5.4.
   Google Scholar
• Thorens, B. 1996. Glucose transporters in the regulation of intestinal, renal, and liver glucose fluxes. American Journal of Physiology-Gastrointestinal and Liver Physiology 270 (4):G541–G53. doi:10.1152/ajpgi.1996.270.4.G541.
   Web of Science ®Google Scholar
• Unnikrishnan, R., R. M. Anjana, and V. Mohan. 2012. Drugs affecting HbA1c levels. Indian Journal of Endocrinology and Metabolism 16 (4):528–31. doi:10.4103/2230-8210.98004.
   PubMedGoogle Scholar
• van de Schoot, R., J. de Bruin, R. Schram, P. Zahedi, J. de Boer, F. Weijdema, B. Kramer, M. Huijts, M. Hoogerwerf, G. Ferdinands, et al. 2021. An open source machine learning framework for efficient and transparent systematic reviews. Nature Machine Intelligence 3 (2):125–33. doi:10.1038/s42256-020-00287-7.
   Google Scholar
• Vessal, M., M. Hemmati, and M. Vasei. 2003. Antidiabetic effects of quercetin in streptozocin-induced diabetic rats. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 135 (3):357–64. doi:10.1016/S1532-0456(03)00140-6.
   PubMed Web of Science ®Google Scholar
• Vilsbøll, T., and J. J. Holst. 2004. Incretins, insulin secretion and type 2 diabetes mellitus. Diabetologia 47 (3):357–66. doi:10.1007/s00125-004-1342-6.
   PubMed Web of Science ®Google Scholar
• Wallace, T. M., J. C. Levy, and D. R. Matthews. 2004. Use and abuse of HOMA modeling. Diabetes Care 27 (6):1487–95. doi:10.2337/diacare.27.6.1487.
   PubMed Web of Science ®Google Scholar
• Waltner-Law, M. E., X. L. Wang, B. K. Law, R. K. Hall, M. Nawano, and D. K. Granner. 2002. Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production. The Journal of Biological Chemistry 277 (38):34933–40. doi:10.1074/jbc.M204672200.
   PubMed Web of Science ®Google Scholar
• Westgate, M. J. 2019. revtools: An R package to support article screening for evidence synthesis. Research Synthesis Methods 10 (4):606–14. doi:10.1002/jrsm.1374.
   PubMed Web of Science ®Google Scholar
• Woodside, J. V., I. S. Young, and M. C. McKinley. 2013. Fruit and vegetable intake and risk of cardiovascular disease. The Proceedings of the Nutrition Society 72 (4):399–406. doi:10.1017/S0029665113003029.
   PubMed Web of Science ®Google Scholar
• Word Health Organization. 2011. Use of glycated haemoglobin (HbA1c) in diagnosis of diabetes mellitus: abbreviated report of a WHO consultation. In: World Health Organization.
   Google Scholar
• World Health Organization. 2021a. Diabetes: Fact-sheets. Accessed 13 April. https://www.who.int/news-room/fact-sheets/detail/diabetes.
   Google Scholar
• World Health Organization. 2021b. Cardiovascular diseases (CVDs). Accessed July 15. https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds).
   Google Scholar
• Wright, L. A.-C., and I. B. Hirsch. 2017. Metrics beyond hemoglobin A1C in diabetes management: Time in range, hypoglycemia, and other parameters. Diabetes Technology & Therapeutics 19 (S2):S16–S26. doi:10.1089/dia.2017.0029.
   PubMedGoogle Scholar
• Wu, Q., H. Chen, Z. Lv, S. Li, B. Hu, Y. Guan, B. Xie, and Z. Sun. 2013. Oligomeric procyanidins of lotus seedpod inhibits the formation of advanced glycation end-products by scavenging reactive carbonyls. Food Chemistry 138 (2–3):1493–502. doi:10.1016/j.foodchem.2012.10.111.
   PubMed Web of Science ®Google Scholar
• Xiao, J., X. Ni, G. Kai, and X. Chen. 2013. A Review on structure-activity relationship of dietary polyphenols inhibiting α-amylase. Critical Reviews in Food Science and Nutrition 53 (5):497–506. doi:10.1080/10408398.2010.548108.
   PubMed Web of Science ®Google Scholar
• Xie, Y., and X. Chen. 2013. Structures required of polyphenols for inhibiting advanced glycation end products formation. Current Drug Metabolism 14 (4):414–31. doi:10.2174/1389200211314040005.
   PubMed Web of Science ®Google Scholar
• Xu, H., J. Luo, J. Huang, and Q. Wen. 2018. Flavonoids intake and risk of type 2 diabetes mellitus: A meta-analysis of prospective cohort studies. Medicine 97 (19):e0686. doi:10.1097/MD.0000000000010686.
   PubMed Web of Science ®Google Scholar
• Yan, J., G. Zhang, J. Pan, and Y. Wang. 2014. α-Glucosidase inhibition by luteolin: Kinetics, interaction and molecular docking. International Journal of Biological Macromolecules 64:213–23. doi:10.1016/j.ijbiomac.2013.12.007.
   PubMed Web of Science ®Google Scholar
• Yang, L., W. Ling, Y. Yang, Y. Chen, Z. Tian, Z. Du, J. Chen, Y. Xie, Z. Liu, and L. Yang. 2017. Role of purified anthocyanins in improving cardiometabolic risk factors in chinese men and women with prediabetes or early untreated diabetes—a randomized controlled trial. Nutrients 9 (10):1104. doi:10.3390/nu9101104.
   PubMed Web of Science ®Google Scholar
• Ye, Y.-B., A.-L. Chen, W. Lu, S.-Y. Zhuo, J. Liu, J.-H. Guan, W.-P. Deng, S. Fang, Y.-B. Li, and Y.-M. Chen. 2015. Daidzein and genistein fail to improve glycemic control and insulin sensitivity in Chinese women with impaired glucose regulation: A double-blind, randomized, placebo-controlled trial. Molecular Nutrition & Food Research 59 (2):240–9. doi:10.1002/mnfr.201400390.
   PubMed Web of Science ®Google Scholar
• Youl, E., G. Bardy, R. Magous, G. Cros, F. Sejalon, A. Virsolvy, S. Richard, J. F. Quignard, R. Gross, P. Petit, et al. 2010. Quercetin potentiates insulin secretion and protects INS-1 pancreatic β-cells against oxidative damage via the ERK1/2 pathway. British Journal of Pharmacology 161 (4):799–814. doi:10.1111/j.1476-5381.2010.00910.x.
   PubMed Web of Science ®Google Scholar
• Zeng, L., G. Zhang, Y. Liao, and D. Gong. 2016. Inhibitory mechanism of morin on α-glucosidase and its anti-glycation properties. Food & Function 7 (9):3953–63. doi:10.1039/c6fo00680a.
   PubMed Web of Science ®Google Scholar