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Review Articles

Concentrations, influencing factors, risk assessment methods, health hazards and analyses of polycyclic aromatic hydrocarbons in dairies: a review

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References

  • Abramsson-Zetterberg, L., P. O. Darnerud, and S. Wretling. 2014. Low intake of polycyclic aromatic hydrocarbons in Sweden: Results based on market basket data and a barbecue study. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 74:107–11. doi: 10.1016/j.fct.2014.09.004. PMID: 30321648.
  • Aguinaga, N., N. Campillo, P. Vinas, and M. Hernandez-Cordoba. 2007. Determination of 16 polycyclic aromatic hydrocarbons in milk and related products using solid-phase microextraction coupled to gas chromatography-mass spectrometry. Analytica Chimica Acta 596 (2):285–90. doi: 10.1016/j.aca.2007.06.005.
  • Alharbi, O. M. L., A. A. Basheer, R. A. Khattab, and I. Ali. 2018. Health and environmental effects of persistent organic pollutants. Journal of Molecular Liquids 263:442–53. doi: 10.1016/j.molliq.2018.05.029.
  • Alshaarawy, O., H. A. Elbaz, and M. E. Andrew. 2016. The association of urinary polycyclic aromatic hydrocarbon biomarkers and cardiovascular disease in the US population. Environment International 89–90:174–8. doi: 10.1016/j.envint.2016.02.006.
  • Anastasio, A., R. Mercogliano, L. Vollano, T. Pepe, and M. L. Cortesi. 2004. Levels of benzo[a]pyrene (BaP) in “mozzarella di bufala campana” cheese smoked according to different procedures. Journal of Agricultural and Food Chemistry 52 (14):4452–5. doi: 10.1021/jf049566n.
  • Badibostan, H., J. Feizy, B. Daraei, S. Shoeibi, S. H. Rajabnejad, J. Asili, S. F. Taghizadeh, J. P. Giesy, and G. Karimi. 2019. Polycyclic aromatic hydrocarbons in infant formulae, follow-on formulae, and baby foods in Iran: An assessment of risk. Food and Chemical Toxicology 131:110640. doi: 10.1016/j.fct.2019.110640.
  • Barone-Adesi, F., R. S. Chapman, D. T. Silverman, X. Z. He, W. Hu, R. Vermeulen, B. F. Ning, J. F. Fraumeni, N. Rothman, and Q. Lan. 2012. Risk of lung cancer associated with domestic use of coal in Xuanwei, China: Retrospective cohort study. BMJ 345 (2):e5414. doi: 10.1136/bmj.e5414.
  • Battisti, C., A. M. Girelli, and A. M. Tarola. 2015. Polycyclic aromatic hydrocarbons (PAHs) in yogurt samples. Food Additives & Contaminants: Part B 8 (1):50–5. doi: 10.1080/19393210.2014.968880.
  • Cai, C., P. Wu, P. Zhou, D. Yang, and Z. Hu. 2020. Detection, risk Assessment, and survey of four polycyclic aromatic hydrocarbon markers in infant formula powder. Journal of Food Quality 2020:1–9. doi: 10.1155/2020/2959532.
  • Ciecierska, M., and M. W. Obiedziński. 2010. Polycyclic aromatic hydrocarbons in infant formulae, follow-on formulae and baby foods available in the Polish market. Food Control 21 (8):1166–72. doi: 10.1016/j.foodcont.2010.01.013.
  • Conde, F. J., J. H. Ayala, A. M. Afonso, and V. Gonzalez. 2005. Polycyclic aromatic hydrocarbons in smoke used to smoke cheese produced by the combustion of rock rose (Cistus monspeliensis) and tree heather (Erica arborea) wood. Journal of Agricultural and Food Chemistry 53 (1):176–82. doi: 10.1021/jf0492013.
  • Dennis, M. J., R. C. Massey, G. Cripps, I. Venn, N. Howarth, and G. Lee. 1991. Factors affecting the polycyclic aromatic hydrocarbon content of cereals, fats and other food products. Food Additives and Contaminants 8 (4):517–30. doi: 10.1080/02652039109374004.
  • Diggs, D. L., A. C. Huderson, K. L. Harris, J. N. Myers, L. D. Banks, P. V. Rekhadevi, M. S. Niaz, and A. Ramesh. 2011. Polycyclic aromatic hydrocarbons and digestive tract cancers: A perspective. Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews 29 (4):324–57. doi: 10.1080/10590501.2011.629974.
  • Dobrinas, S., A. Soceanu, V. Popescu, and V. Coatu. 2016. Polycyclic aromatic hydrocarbons and pesticides in milk powder. The Journal of Dairy Research 83 (2):261–5. doi: 10.1017/S0022029916000169.
  • Drwal, E., A. Rak, and E. L. Gregoraszczuk. 2019. Review: Polycyclic aromatic hydrocarbons (PAHs)-Action on placental function and health risks in future life of newborns. Toxicology 411:133–42. doi: 10.1016/j.tox.2018.10.003.
  • Duedahl-Olesen, L., and A. C. Ionas. 2021. Formation and mitigation of PAHs in barbecued meat – a review. Critical Reviews in Food Science and Nutrition. Advance online publication. doi: 10.1080/10408398.2020.1867056.
  • EFSA. 2008. Polycyclic aromatic hydrocarbons in food scientific opinion of the panel on contaminants in the food chain. The EFSA Journal 724:1–114.
  • EPA. Use of Monte Carlo simulation in risk assessments. Last Modified September 28, 2021. Accessed February 6, 2022. https://www.epa.gov/risk/use-monte-carlo-simuationrisk-assessments.
  • Esposito, M., A. Citro, L. Marigliano, V. Urbani, G. Seccia, M. P. Marotta, and C. Nicola. 2015. Influence of different smoking techniques on contamination by polycyclic aromatic hydrocarbons in traditional smoked Mozzarella di Bufala Campana. International Journal of Dairy Technology 68 (1):97–104. doi: 10.1111/1471-0307.12179.
  • Fasano, E., F. Esposito, G. Scognamiglio, R. C. Amodio, and T. Cirillo. 2016. Detection of polycyclic aromatic hydrocarbons in smoked buffalo mozzarella cheese produced in Campania Region, Italy. Journal of the Science of Food and Agriculture 96 (5):1704–8. doi: 10.1002/jsfa.7275.
  • Gao, Y., Y. Qin, F. Xiong, and L. Zhao. 2020. Determination of trace polycyclic aromatic hydrocarbons in water and milk using solid-phase extraction packed with graphene/chitosan composite aerogel prior to gas chromatography-mass spectrometry. Journal of Separation Science 43 (20):3940–8. doi: 10.1002/jssc.202000448.
  • Garcia Londoño, V. A., C. M. Reynoso, and S. Resnik. 2017. Polycyclic aromatic hydrocarbons in milk powders marketed in Uruguay. Food Additives & Contaminants. Part B, Surveillance 10 (4):284–91. doi: 10.1080/19393210.2017.1349191.
  • Girelli, A. M., D. Sperati, and A. M. Tarola. 2014. Determination of polycyclic aromatic hydrocarbons in Italian milk by HPLC with fluorescence detection. Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment 31 (4):703–10. doi: 10.1080/19440049.2013.878959.
  • Gong, G., S. Wu, and X. Wu. 2019. Effects of storage time and temperature on toxic aldehydes and polycyclic aromatic hydrocarbons in flavouring oil gravy during storage. LWT 116:108510. doi: 10.1016/j.lwt.2019.108510.
  • Greim, H. 2008. Gesundheitsschadliche Arbeitsstoffe, Toxikologischarbeitsmedizinische Begründungen von MAK-Werten und Einstufungen. New Jersey: Wiley.
  • Grova, N., C. Feidt, C. Crepineau, C. Laurent, P. E. Lafargue, A. Hachimi, and G. Rychen. 2002. Detection of polycyclic aromatic hydrocarbon levels in milk collected near potential contamination sources. Journal of Agricultural and Food Chemistry 50 (16):4640–2. doi: 10.1021/jf0201071.
  • Guillen, M. D., G. Palencia, M. L. Ibargoitia, M. Fresno, and P. Sopelana. 2011. Contamination of cheese by polycyclic aromatic hydrocarbons in traditional smoking. Influence of the position in the smokehouse on the contamination level of smoked cheese. Journal of Dairy Science 94 (4):1679–90. doi: 10.3168/jds.2010-3647.
  • Guillen, M. D., G. Palencia, P. Sopelana, and M. L. Ibargoitia. 2007. Occurrence of polycyclic aromatic hydrocarbons in artisanal Palmero cheese smoked with two types of vegetable matter. Journal of Dairy Science 90 (6):2717–25. doi: 10.3168/jds.2006-452.
  • Guillen, M. D., and P. Sopelana. 2004. Occurrence of polycyclic aromatic hydrocarbons in smoked cheese. Journal of Dairy Science 87 (3):556–64. doi: 10.3168/jds.S0022-0302(04)73197-5.
  • Gul, O., M. Dervisoglu, M. Mortas, O. Aydemir, E. Ilhan, and K. Aksehir. 2015. Evaluation of polycyclic aromatic hydrocarbons in Circassian cheese by high-performance liquid chromatography with fluorescence detection. Journal of Food Composition and Analysis 37:82–6. doi: 10.1016/j.jfca.2014.07.004.
  • Han, J., M. Kim, and H. Shin. 2014. Evaluation of polycyclic aromatic hydrocarbon contents and risk assessment for infant formula in Korea. Journal of the Korean Society for Applied Biological Chemistry 57 (2):173–9. doi: 10.1007/s13765-013-4219-x.
  • IARC. 2010. IARC Monographs. Accessed May 27, 2021. https://publications.iarc.fr/110.
  • Iwegbue, C. M., and F. I. Bassey. 2013. Concentrations and health hazards of polycyclic aromatic hydrocarbons in selected commercial brands of milk. Journal of Food Measurement and Characterization 7 (4):177–84. doi: 10.1007/s11694-013-9153-4.
  • Iwegbue, C. M., A. A. Ogbuta, J. O. Otutu, G. Obi, F. E. Egobueze, and B. S. Martincigh. 2021. Evaluation of human exposure to polycyclic aromatic hydrocarbons from some edible oils and shea butter in Nigeria. Polycyclic Aromatic Compounds 41 (1):109–23. doi: 10.1080/10406638.2019.1570951.
  • Iwegbue, C. M., J. N. Edeme, G. O. Tesi, F. I. Bassey, B. S. Martincigh, and G. E. Nwajei. 2014. Polycyclic aromatic hydrocarbon concentrations in commercially available infant formulae in Nigeria: Estimation of dietary intakes and risk assessment. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 72:221–7. doi: 10.1016/j.fct.2014.06.026.
  • Iwegbue, C. M. A., G. O. Tesi, G. Obi, G. E. Obi-Iyeke, U. A. Igbuku, and B. S. Martincigh. 2016. Concentrations, health risks and sources of polycyclic aromatic hydrocarbons in Nigerian honey. Toxicology and Environmental Health Sciences 8 (1):28–42. doi: 10.1007/s13530-016-0259-z.
  • Jafarabadi, A. R., S. Mashjoor, A. R. Bakhtiari, and C. Jadot. 2020. Dietary intake of polycyclic aromatic hydrocarbons (PAHs) from coral reef fish in the Persian Gulf - Human health risk assessment. Food Chemistry 329:127035. doi: 10.1016/j.foodchem.2020.127035.
  • Kacmaz, S. 2019. Polycyclic aromatic hydrocarbons in retail Turkish yogurts. Quality Assurance and Safety of Crops & Foods 11 (4):361–7. doi: 10.3920/QAS2018.1521.
  • Kakareka, S. V., and T. I. Kukharchyk. 2003. PAH emission from the open burning of agricultural debris. Science of the Total Environment 308 (13):257–61. doi: 10.1016/S0048-9697(02)00650-2.
  • Khorshidian, N., M. Y. Asli, H. Hosseini, M. Shadnoush, and A. M. Mortazavian. Potential anticarcinogenic effects of lactic acid bacteria and probiotics in detoxification of process-induced food toxicants. Iranian Journal of Cancer Prevention 9 (5):7920 doi: 10.17795/ijcp-7920.
  • Kiani, A., M. Ahmadloo, M. Moazzen, N. Shariatifar, S. Shahsavari, M. Arabameri, M. M. Hasani, A. Azari, and M. A. Abdel-Wahhab. 2021. Monitoring of polycyclic aromatic hydrocarbons and probabilistic health risk assessment in yogurt and butter in Iran. Food Science & Nutrition 9 (4):2114–28. doi: 10.1002/fsn3.2180.
  • Ledesma, E., M. Rendueles, and M. Diaz. 2014. Benzo(a)pyrene penetration on a smoked meat product during smoking time. Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment 31 (10):1688–98. doi: 10.1080/19440049.2014.949875.
  • Lee, S. Y., J. Y. Lee, and H. S. Shin. 2015. Evaluation of chemical analysis method and determination of polycyclic aromatic hydrocarbons content from seafood and dairy products. Toxicological Research 31 (3):265–71. doi: 10.5487/TR.2015.31.3.265.
  • Loutfy, N., M. Fuerhacker, P. Tundo, S. Raccanelli, and M. T. Ahmed. 2007. Monitoring of polychlorinated dibenzo-p-dioxins and dibenzofurans, dioxin-like PCBs and polycyclic aromatic hydrocarbons in food and feed samples from Ismailia city, Egypt. Chemosphere 66 (10):1962–70. doi: 10.1016/j.chemosphere.2006.07.081.
  • Ma, Y., and S. Harrad. 2015. Spatiotemporal analysis and human exposure assessment on polycyclic aromatic hydrocarbons in indoor air, settled house dust, and diet: A review. Environment International 84:7–16. doi: 10.1016/j.envint.2015.07.006.
  • Makoś, P., A. Przyjazny, and G. Boczkaj. 2018. Hydrophobic deep eutectic solvents as “green” extraction media for polycyclic aromatic hydrocarbons in aqueous samples. Journal of Chromatography A 1570:28–37. doi: 10.1016/j.chroma.2018.07.070.
  • Martin-Tornero, E., A. Luque-Uria, I. Duran-Meras, and A. Espinosa-Mansilla. 2020. A novel analytical methodology for the determination of hydroxy polycyclic aromatic hydrocarbons in breast and cow milk samples. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 1136:121912. doi: 10.1016/j.jchromb.2019.121912.
  • Martorell, I., G. Perello, R. Marti-Cid, V. Castell, J. M. Llobet, and J. L. Domingo. 2010. Polycyclic aromatic hydrocarbons (PAH) in foods and estimated PAH intake by the population of Catalonia, Spain: Temporal trend. Environment International 36 (5):424–32. doi: 10.1016/j.envint.2010.03.003.
  • Mortamais, M., J. Pujol, B. L. Van Drooge, D. Macia, G. Martinez-Vilavella, C. Reynes, R. Sabatier, I. Rivas, J. Grimalt, J. Forns, et al. 2017. Effect of exposure to polycyclic aromatic hydrocarbons on basal ganglia and attention-deficit hyperactivity disorder symptoms in primary school children. Environment International 105:12–9. doi: 10.1016/j.envint.2017.04.011.
  • Naccari, C., M. Cristani, F. Giofrè, M. Ferrante, L. Siracusa, and D. Trombetta. 2011. PAHs concentration in heat-treated milk samples. Food Research International 44 (3):716–24. doi: 10.1016/j.foodres.2010.12.029.
  • Naccari, C., M. Cristani, P. Licata, F. Giofre, and D. Trombetta. 2008. Levels of benzo[a]pyrene and benzo[a]anthracene in smoked “Provola” cheese from Calabria (Italy). Food Additives & Contaminants. Part B, Surveillance 1 (1):78–84. doi: 10.1080/19393210802236968.
  • Nisbet, I. C., and P. K. LaGoy. 1992. Toxic equivalency factors (TEFs) for polycyclic aromatic hydrocarbons (PAHs). Regulatory Toxicology and Pharmacology: RTP 16 (3):290–300. doi: 10.1016/0273-2300(92)90009-X.
  • Olsson, A. C., J. Fevotte, T. Fletcher, A. Cassidy, A. Mannetje, D. Zaridze, N. Szeszenia-Dabrowska, P. Rudnai, J. Lissowska, E. Fabianova, et al. 2010. Occupational exposure to polycyclic aromatic hydrocarbons and lung cancer risk: A multicenter study in Europe. Occupational and Environmental Medicine 67 (2):98–103. doi: 10.1136/oem.2009.046680.
  • Pagliuca, G., T. Gazzotti, E. Zironi, G. P. Serrazanetti, D. Mollica, and R. Rosmini. 2003. Determination of high molecular mass polycyclic aromatic hydrocarbons in a typical Italian smoked cheese by HPLC-FL. Journal of Agricultural and Food Chemistry 51 (17):5111–5. doi: 10.1021/jf034305j.
  • Perera, F. P., H. W. Chang, D. Tang, E. L. Roen, J. Herbstman, A. Margolis, T. J. Huang, R. L. Miller, S. Wang, and V. Rauh. 2014. Early-life exposure to polycyclic aromatic hydrocarbons and ADHD behavior problems. PLoS One 9 (11):e111670. doi: 10.1371/journal.pone.0111670.
  • Perera, F. P., V. Rauh, R. M. Whyatt, W. Y. Tsai, D. L. Tang, D. Diaz, L. Hoepner, D. Barr, Y. H. Tu, D. Camann, et al. 2006. Effect of prenatal exposure to airborne polycyclic aromatic hydrocarbons on neurodevelopment in the first 3 years of life among inner-city children. Environmental Health Perspectives 114 (8):1287–92. doi: 10.1289/ehp.9084.
  • Perera, F. P., Z. G. Li, R. Whyatt, L. Hoepner, S. A. Wang, D. Camann, and V. Rauh. 2009. Prenatal airborne polycyclic aromatic hydrocarbon exposure and child IQ at age 5 years. Pediatrics 124 (2):e195–202. doi: 10.1542/peds.2008-3506.
  • Qin, Y. Y., C. K. M. Leung, A. O. W. Leung, J. S. Zheng, and M. H. Wong. 2011. Persistent organic pollutants in food items collected in Hong Kong. Chemosphere 82 (9):1329–36. doi: 10.1016/j.chemosphere.2010.12.009.
  • Rawash, E. A., G. G. Mohamed, E. R. Souaya, L. H. Khalil, G. A. El-Chaghaby, and M. H. El-Gammal. 2018. Distribution and health hazards of polycyclic aromatic hydrocarbons in Egyptian milk and dairy-based products. Beverages 4 (3):63. doi: 10.3390/beverages4030063.
  • Richter-Brockmann, S., and C. Achten. 2018. Analysis and toxicity of 59 PAH in petrogenic and pyrogenic environmental samples including dibenzopyrenes, 7H-benzo[c]fluorene, 5-methylchrysene and 1-methylpyrene. Chemosphere 200:495–503. doi: 10.1016/j.chemosphere.2018.02.146.
  • Rocha, H. B., A. C. R. da Silva, C. F. Balthazar, J. T. Guimarães, M. Q. Freitas, E. A. Esmerino, T. C. Pimentel, R. L. Raices, A. G. Cruz, and S. L. Quiterio. 2020. Charcoal-barbecued Coalho cheese: An investigation on the formation and ingestion of polycyclic aromatic hydrocarbons. LWT 124:109186. doi: 10.1016/j.lwt.2020.109186.
  • Rodríguez-Hernández, Á., M. Camacho, L. D. Boada, N. Ruiz-Suarez, M. Almeida-González, L. A. Henríquez-Hernández, M. Zumbado, and O. P. Luzardo. 2015. Daily intake of anthropogenic pollutants through yogurt consumption in the Spanish population. Journal of Applied Animal Research 43 (4):373–83. doi: 10.1080/09712119.2014.978777.
  • Saito, E., N. Tanaka, A. Miyazaki, and M. Tsuzaki. 2014. Concentration and particle size distribution of polycyclic aromatic hydrocarbons formed by thermal cooking. Food Chemistry 153:285–91. doi: 10.1016/j.foodchem.2013.12.055.
  • Santonicola, S., A. De Felice, L. Cobellis, N. Passariello, A. Peluso, N. Murru, M. C. Ferrante, and R. Mercogliano. 2017. Comparative study on the occurrence of polycyclic aromatic hydrocarbons in breast milk and infant formula and risk assessment. Chemosphere 175:383–90. doi: 10.1016/j.chemosphere.2017.02.084.
  • Santonicola, S., S. Albrizio, N. Murru, M. C. Ferrante, and R. Mercogliano. 2017. Study on the occurrence of polycyclic aromatic hydrocarbons in milk and meat/fish based baby food available in Italy. Chemosphere 184:467–72. doi: 10.1016/j.chemosphere.2017.06.017.
  • Semanova, J., B. Sklarsova, P. Simon, and P. Simko. 2016. Elimination of polycyclic aromatic hydrocarbons from smoked sausages by migration into polyethylene packaging. Food Chemistry 201:1–6.
  • Shariatifar, N., M. Dadgar, Y. Fakhri, S. Shahsavari, M. Moazzen, M. Ahmadloo, A. Kiani, S. Aeenehvand, S. Nazmara, and A. Mousavi Khanegah. 2020. Levels of polycyclic aromatic hydrocarbons in milk and milk powder samples and their likely risk assessment in Iranian population. Journal of Food Composition and Analysis 85:103331. doi: 10.1016/j.foodchem.2016.01.057.
  • Singh, L., J. G. Varshney, and T. Agarwal. 2016. Polycyclic aromatic hydrocarbons’ formation and occurrence in processed food. Food Chemistry 199:768–81. doi: 10.1016/j.foodchem.2015.12.074.
  • Suchanová, M., J. Hajšlová, M. Tomaniová, V. Kocourek, and L. Babička. 2008. Polycyclic aromatic hydrocarbons in smoked cheese. Journal of the Science of Food and Agriculture 88 (8):1307–17. doi: 10.1002/jsfa.3198.
  • Sun, Y., K. Yan, S. Wu, and G. Gong. 2020. Occurrence, spatial distribution and impact factors of 16 polycyclic aromatic hydrocarbons in milks from nine countries. Food Control. 113:107197. doi: 10.1016/j.foodcont.2020.107197.
  • Sun, Y., S. Wu, and G. Gong. 2019. Trends of research on polycyclic aromatic hydrocarbons in food: A 20-year perspective from 1997 to 2017. Trends in Food Science & Technology 83:86–98. doi: 10.1016/j.tifs.2018.11.015.
  • Wang, J., L. Jia, W. Wei, S. Lang, P. Shao, and X. Fan. 2016. Determination of polycyclic aromatic hydrocarbons in edible Oil by gel permeation chromatography and ultra-high performance liquid chromatography coupled with diode array detector and fluorescence detector. Acta Chromatographica 28 (3):415–27. doi: 10.1556/1326.2016.28.3.11.
  • Wang, M., C. Cheng, C. Liu, and Y. Yang. 2018. Hollow fiber supported ionic liquids liquid-phase micro-extraction followed by high-performance liquid chromatography for the determination of polycyclic aromatic hydrocarbons in milk samples. Journal of Chromatographic Science 56 (1):74–80. doi: 10.1093/chromsci/bmx075.
  • Wu, M., Z. Xia, Q. Zhang, J. Yin, Y. Zhou, and H. Yang. 2016. Distribution and health risk assessment on dietary exposure of polycyclic aromatic hydrocarbons in vegetables in Nanjing, China. Journal of Chemistry 2016:1–8. doi: 10.1155/2016/1581253.
  • Wu, S., G. Gong, K. Yan, Y. Sun, and L. Zhang. 2020. Polycyclic aromatic hydrocarbons in edible oils and fatty foods: Occurrence, formation, analysis, change and control. In Advances in Food and Nutrition Research, ed. D. Granato, vol. 93, 59–112. Amsterdam: Elsevier.
  • Yan, K., S. Wu, G. Gong, L. Xin, and Y. Ge. 2021. Simultaneous determination of typical chlorinated, oxygenated, and European union priority polycyclic aromatic hydrocarbons in milk samples and milk powders. Journal of Agricultural and Food Chemistry 69 (13):3923–31. doi: 10.1021/acs.jafc.1c00283.
  • Yebra-Pimentel, I., R. Fernández-González, E. Martínez-Carballo, and J. Simal-Gándara. 2015. A critical review about the health risk assessment of PAHs and their metabolites in foods. Critical Reviews in Food Science and Nutrition 55 (10):1383–405. doi: 10.1080/10408398.2012.697497.
  • Zhang, Y., X. Chen, and Y. Zhang. 2021. Analytical chemistry, formation, mitigation, and risk assessment of polycyclic aromatic hydrocarbons: From food processing to in vivo metabolic transformation. Comprehensive Reviews in Food Science and Food Safety 20 (2):1422–56. doi: 10.1111/1541-4337.12705.

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