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Review Articles

Associations of the consumption of unprocessed red meat and processed meat with the incidence of cardiovascular disease and mortality, and the dose-response relationship: A systematic review and meta-analysis of cohort studies

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References

  • Al-Shaar, L., A. Satija, D. Wang, E. Rimm, S. Smith-Warner, M. Stampfer, F. Hu, and W. Willett. 2020. Red meat intake and risk of coronary heart disease among US men: Prospective cohort study. BMJ (Clinical Research ed.) 371:m4141. doi: 10.1136/bmj.m4141.
  • Amiano, P., S. Chamosa, N. Etxezarreta, L. Arriola, M.-J. Sánchez, E. Ardanaz, E. Molina-Montes, M.-D. Chirlaque, C. Moreno-Iribas, J.-M. Huerta, et al. 2016. Unprocessed red meat and processed meat consumption and risk of stroke in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC). European Journal of Clinical Nutrition 70 (3):313–9. doi: 10.1038/ejcn.2015.150.
  • Ascherio, A., W. C. Willett, E. B. Rimm, E. L. Giovannucci, and M. J. Stampfer. 1994. Dietary iron intake and risk of coronary disease among men. Circulation 89 (3):969–74. doi: 10.1161/01.CIR.89.3.969.
  • Baker, P, and S. Friel. 2014. Processed foods and the nutrition transition: Evidence from Asia. Obesity Reviews: An Official Journal of the International Association for the Study of Obesity 15 (7):564–77. doi: 10.1111/obr.12174.
  • Bechthold, A., H. Boeing, C. Schwedhelm, G. Hoffmann, S. Knüppel, K. Iqbal, S. D. Henauw, N. Michels, B. Devleesschauwer, S. Schlesinger, et al. 2019. Food groups and risk of coronary heart disease, stroke and heart failure: A systematic review and dose-response meta-analysis of prospective studies. Critical Reviews in Food Science and Nutrition 59 (7):1071–90. doi: 10.1080/10408398.2017.1392288.
  • Bernstein, A. M., A. Pan, K. M. Rexrode, M. Stampfer, F. B. Hu, D. Mozaffarian, and W. C. Willett. 2012. Dietary protein sources and the risk of stroke in men and women stroke. Stroke 43 (3):637–44. doi: 10.1161/STROKEAHA.111.633404.
  • Bernstein, A. M., Q. Sun, F. B. Hu, M. J. Stampfer, J. E. Manson, and W. C. Willett. 2010. Major dietary protein sources and risk of coronary heart disease in women. Circulation 122 (9):876–83. doi: 10.1161/CIRCULATIONAHA.109.915165.
  • Bronzato, S, and A. Durante. 2017. A contemporary review of the relationship between red meat consumption and cardiovascular risk. International Journal of Preventive Medicine 8 (40):40–7. doi: 10.4103/ijpvm.IJPVM_206_16.
  • Burke, V., Y. Zhao, A. H. Lee, E. Hunter, R. M. Spargo, M. Gracey, R. M. Smith, L. J. Beilin, and I. B. Puddey. 2007. Health-related behaviours as predictors of mortality and morbidity in Australian Aborigines. Preventive Medicine 44 (2):135–42. doi: 10.1016/j.ypmed.2006.09.008.
  • Chowdhury, R., S. Warnakula, S. Kunutsor, F. Crowe, H. Ward, L. Johnson, O. Franco, A. Butterworth, N. Forouhi, S. Thompson, et al. 2014. Association of dietary, circulating, and supplement fatty acids with coronary risk: A systematic review and meta-analysis. Annals of Internal Medicine 160 (6):398–406. doi: 10.7326/M13-1788.
  • De Medeiros, G. C. B. S, et al. 2019. Red meat consumption, risk of incidence of cardiovascular disease and cardiovascular mortality, and the dose–response effect. Medicine 98 (38):e17271. doi: 10.1097/MD.0000000000017271.
  • Del Gobbo, L. C., S. Kalantarian, F. Imamura, R. Lemaitre, D. S. Siscovick, B. M. Psaty, and D. Mozaffarian. 2015. Contribution of major lifestyle risk factors for incident heart failure in older adults. The cardiovascular health study. JACC: Heart Failure 3 (7):520–8. doi: 10.1016/j.jchf.2015.02.009.
  • DerSimonian, R, and N. Laird. 1986. Meta-analysis in clinical trials. Controlled Clinical Trials 7:177–88. doi: 10.1016/0197-2456(86)90046-2.
  • DGE. 2010. 10 guidelines of the German Nutrition Society (DGE) for a wholesome diet. https://www.dge.de/ernaehrungspraxis/vollwertige-ernaehrung/10-regeln-der-dge.
  • Forstermann, U. 2008. Oxidative stress in vascular disease: Causes, defense mechanisms and potential therapies. Nature Clinical Practice: Cardiovascular Medicine 5 (6):338–49. doi: 10.1038/ncpcardio1211.
  • Haring, B. S., N. Gronroos, J. A. Nettleton, M. C. W. Ballmoos, E. Selvin, and A. Alonso. 2014. Dietary protein intake and coronary heart disease in a large community based cohort: Results from the atherosclerosis risk in communities (ARIC) study. PLoS One. 9 (10):1–7.
  • Kaluza, J., A. Åkesson, and A. Wolk. 2014. Processed and unprocessed red meat consumption and risk of heart failure. Circulation 7:552–7. doi: 10.1161/CIRCHEARTFAILURE.113.000921.
  • Kaluza, J., A. Åkesson, and A. Wolk. 2015. Long-term processed and unprocessed red meat consumption and risk of heart failure: A prospective cohort study of women. International Journal of Cardiology 193 (2015):42–6. doi.org/ doi: 10.1016/j.ijcard.2015.05.044.
  • Koeth, R. A., Z. Wang, B. S. Levison, J. A. Buffa, E. Org, B. T. Sheehy, E. B. Britt, X. Fu, Y. Wu, L. Li, et al. 2013. Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis. Nature Medicine 19 (5):576–87. doi: 10.1038/nm.3145.
  • Lacroix, S., J. Cantin, and A. Nigam. 2017. Contemporary issues regarding nutrition in cardiovascular rehabilitation. Annals of Physical and Rehabilitation Medicine 60:1–7. doi: 10.1016/j.rehab.2016.07.262.
  • Larsson, S. C., J. Virtamo, and A. Wolk. 2011a. Red meat consumption and risk of stroke in Swedish men. The American Journal of Clinical Nutrition 94 (2):417–21. doi: 10.3945/ajcn.111.015115.
  • Larsson, S. C., J. Virtamo, and A. Wolk. 2011b. Red meat consumption and risk of stroke in Swedish women. Stroke 42 (2):324–9. doi: 10.1161/STROKEAHA.110.596510.
  • Liberati, A., D. G. Altman, J. Tetzlaff, C. Mulrow, P. C. Gotzsche, J. P. A. Ioannidis, M. Clarke, P. J. Devereaux, J. Kleijnen, and D. Moher. 2009. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. Plos Medicine 6 (7):1–28. doi: 10.1371/journal.pmed.1000100.
  • Micha, R., G. Michas, and D. Mozaffarian. 2012. Unprocessed red and processed meats and risk of coronary artery disease and type 2 diabetes-an updated review of the evidence. Current Atherosclerosis Reports 14 (6):515–24. doi: 10.1007/s11883-012-0282-8.
  • Monteiro, C. A., J. C. Moubarac, G. Cannon, S. W. Ng, and B. Popkin. 2013. Ultra-processed products are becoming dominant. Obesity Reviews 14 (supll. 2):21–8. doi: 10.1111/obr.12107.
  • Moubarac, J.-C., M. Batal, A. P. B. Martins, R. Claro, R. B. Levy, G. Cannon, and C. Monteiro. 2014. Processed and ultra-processed Food products: consumption trends in Canada from 1938 to 2011. Canadian Journal of Dietetic Practice and Research: A Publication of Dietitians of Canada = Revue Canadienne de la Pratique et de la Recherche en Dietetique: une Publication Des Dietetistes du Canada 75 (1):15–21. doi: 10.3148/75.1.2014.15.
  • Munn, Z., S. Moola, K. Lisy, D. Riitano, and C. Tufanaru. 2015. Methodological guidance for systematic reviews of observational epidemiological studies reporting prevalence and cumulative incidence data. International Journal of Evidence-Based Healthcare 13 (3):147–53. doi: 10.1097/XEB.0000000000000054.
  • Nagao, M., H. Iso, K. Yamagishi, C. Date, and A. Tamakoshi. 2012. Meat consumption in relation to mortality from cardiovascular disease among Japanese men and women. European Journal of Clinical Nutrition 66 (6):687–93. doi: 10.1038/ejcn.2012.6.
  • Nelson, D. L, and M. M. Cox. 2017. Lehninger: Princípios de Bioquímica. [Lehninger: Principles of Biochemitry]. 7th ed. SP/Brasil: Editora Sarvier.
  • Nettleton, J. A., L. M. Steffen, L. R. Loehr, W. D. Rosamond, and A. R. Folsom. 2008. Incident heart failure is associated with lower whole-grain intake and greater high-fat dairy and egg intake in the atherosclerosis risk in communities (ARIC) study. Journal of the American Dietetic Association 108 (11):1881–7. doi: 10.1016/j.jada.2008.08.015.
  • Patino, C. M, and J. C. Ferreira. 2016. Test for trend: Evaluating dose-response effects in association studies. Jornal Brasileiro de Pneumologia: Publicacao Oficial da Sociedade Brasileira de Pneumologia e Tisilogia 42 (4):240. doi: 10.1590/S1806-37562016000000225.
  • Quintana, P. D. A., D. Sookthai, C. Wittenbecher, M. E. Graf, R. Schübel, T. Johnson, V. Katzke, P. Jakszyn, R. Kaaks, and T. Kühn. 2018. Red meat consumption and risk of cardiovascular diseases-is increased iron load a possible link? The American Journal of Clinical Nutrition 107 (1):113–9. doi: 10.1093/ajcn/nqx014.
  • Saito, E. 2020. Association between meat intake and mortality due to all-cause and major causes of death in a Japanese population. PLoS One 15 (12):1–14. doi: 10.1371/journal.pone.0244007.
  • Sauvaget, C., J. Nagano, N. Allen, E. J. Grant, and V. Beral. 2003. Intake of animal products and stroke mortality in the Hiroshima/Nagasaki life span study. International Journal of Epidemiology 32 (4):536–43. doi: 10.1093/ije/dyg151.
  • Schwingshackl, L., C. Schwedhelm, G. Hoffmann, A.-M. Lampousi, S. Knüppel, K. Iqbal, A. Bechthold, S. Schlesinger, and H. Boeing. 2017. Food groups and risk of all-cause mortality: A systematic review and meta-analysis of prospective studies. The American Journal of Clinical Nutrition 105 (6):1462–73. doi: 10.1093/ajcn/nqz015.
  • Seidelmann, S. B., B. Claggett, S. Cheng, M. Henglin, A. Shah, L. M. Steffen, A. R. Folsom, E. B. Rimm, W. C. Willett, and S. D. Solomon. 2018. Dietary carbohydrate intake and mortality: A prospective cohort study and meta-analysis. The Lancet 3 (9):419–28. doi: 10.1016/S2468-2667(18)30135-X.
  • Singh, G. M., G. Danaei, F. Farzadfar, G. A. Stevens, M. Woodward, D. Wormser, S. Kaptoge, G. Whitlock, Q. Qiao, and S. Lewington. 2013. The age-specific quantitative effects of metabolic rish factors on cardiovascular diseases and diabetes: A pooled analysis. PLoS One 8 (7):1–10. doi: 10.1371/journal.pone.0065174.
  • Smyth, A., A. O’Donnell, S. Mente, and Yusuf, M. 2015. Dietary sodium and cardiovascular. Current Hypertension Reports 17:1–8. doi: 10.1007/s11906-015-0559-8.
  • Souza, R. J., A. Mente, A. Maroleanu, A. I. Cozma, V. Ha, T. Kishibe, E. Uleryk, P. Budylowski, H. Schünemann, J. Beyene, et al. 2015. Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: Systematic review and meta-analysis of observational studies. The BMJ 351:1–10.
  • Stewart, B. W., S. D. Smet, D. Corpet, M. Meurillon, G. Caderni, S. Rohrmann, P. Verger, S. Sasazuki, K. Wakabayashi, M. P. Weijenberg, et al. 2015. Carcinogenicity of consumption of red and processed meat. The Lancet 16:1599–600. doi: 10.1016/S1470-2045(15)00444-1.
  • Stewart, R. A. H., L. Wallentin, J. Benatar, N. Danchin, E. Hagström, C. Held, S. Husted, E. Lonn, A. Stebbins, K. Chiswell, et al. 2016. Dietary patterns and the risk of major adverse cardiovascular events in a global study of high-risk patients with stable coronary heart disease. European Heart Journal 37 (25):1993–2001.
  • Takata, Y., X.-O. Shu, Y.-T. Gao, H. Li, X. Zhang, J. Gao, H. Cai, G. Yang, Y.-B. Xiang, and W. Zheng. 2013. Red meat and poultry intakes and risk of total and cause-specific mortality: results from cohort studies of chinese adults in shanghai. PLoS One 8 (2):1–12.
  • USDA. 2018. Country Production Exports Country Production Exports Country Production Exports Livestock and Poultry: World Markets and trade Pork and Chicken Meat Trade Strengthen, Beef Trade Slackens in 2019. Last Modified October 11, 2018. Accessed November 28, 2018. https://downloads.usda.library.cornell.edu/usda-esmis/files/73666448x/mg74qq69r/j6731729p/livestock_poultry.pdf.
  • USDA. Dietary Guidelines for Americans 2015–2020 Eighth Edition. 2015. 8rd ed. https://health.gov/dietaryguidelines/2015/guidelines/.of
  • WCRF. AICR. 2018. Continuous Update Project Expert Report. Meat, fish and dairy products and the risk of cancer. https://www.wcrf.org/sites/default/files/Meat-Fish-and-Dairy-products.pdf
  • Wells, G. A. B. Shea, D. O’Connel, J. Peterson, V. Welch, M. Losos, and P. Tugwell. 2015. The Newcastle-Ottowa Scale (NOS) for assessing the quailty of nonrandomised studies in meta-analyes. Accessed March 28, 2019. http://www.ohrica/programs/clinical_epidemiology/oxfordhtm 2009 Feb 1.
  • Whiteman, D., J. Muir, L. Jones, M. Murphy, and T. Key. 1999. Dietary questions as determinants of mortality: The OXCHECK experience. Public Health Nutrition 2 (4):477–87.
  • WHO. 2003. Diet, nutrition and the prevention of chronic diseases. Report of joint WHO/FAO Expert Consultation. World Health Organization. ISBN 92 4 120916.
  • Willett, W. 2001. Invited commentary: A further look at dietary questionnaire validation. American Journal of Epidemiology 154 (12):1100–2. doi: 10.1093/aje/154.12.1100.
  • Wiseman, M. R. Thompson, and K. Allen. 2018. Diet, Nutrition, Physical Activity and Cancer: a Global Perspective. A summary of the Third Expert Report. World Cancer Research Fund International. ISBN (print): 978-1-912259-46-5
  • Würtz, A. M. L., M. D. Hansen, A. Tjønneland, E. B. Rimm, E. B. Schmidt, K. Overvad, and M. U. Jakobsen. 2016. Substitution of meat and fish with vegetables or potatoes and risk of myocardial infarction. The British Journal of Nutrition 116 (9):1602–10. doi: 10.1017/S0007114516003500.
  • Yaemsiri, S., S. Sen, L. Tinker, W. Rosamond, S. Wassertheil-Smoller, and K. He. 2012. Trans fat, aspirin, and ischemic stroke in postmenopausal women. Annals of Neurology 72 (5):704–415. doi: 10.1002/ana.23555.
  • Zhang, W., H. Iso, T. Ohira, C. Date, N. Tanabe, S. Kikuchi, and A. Tamakoshi. 2012. Associations of dietary iron intake with mortality from cardiovascular disease: The JACC study. Journal of Epidemiology 22 (6):484–93. doi: 10.2188/jea.je20120006.

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