Health benefits of astaxanthin against age-related diseases of multiple organs: A comprehensive review

References

• Abdelzaher, L. A., T. Imaizumi, T. Suzuki, K. Tomita, M. Takashina, and Y. Hattori. 2016. Astaxanthin alleviates oxidative stress insults-related derangements in human vascular endothelial cells exposed to glucose fluctuations. Life Sciences 150:24–31. doi: 10.1016/j.lfs.2016.02.087.
   PubMed Web of Science ®Google Scholar
• Additives and Feed. 2014. Scientific opinion on the safety and efficacy of synthetic astaxanthin as feed additive for salmon and trout, other fish, ornamental fish, crustaceans and ornamental birds. EFSA Journal 12 (6):3724.
   Google Scholar
• Ahmadi, A. R., and R. Ayazi-Nasrabadi. 2021. Astaxanthin protective barrier and its ability to improve the health in patients with COVID-19. Iranian Journal of Microbiology 13 (4):434–41. doi: 10.18502/ijm.v13i4.6965.
   PubMed Web of Science ®Google Scholar
• Ahn, Y. T., M. S. Kim, Y. S. Kim, and W. G. An. 2020. Astaxanthin reduces stemness markers in BT20 and T47D breast cancer stem cells by inhibiting expression of pontin and mutant p53. Marine Drugs 18 (11):577. doi: 10.3390/md18110577.
   PubMed Web of Science ®Google Scholar
• Akca, G., H. Eren, L. Tumkaya, T. Mercantepe, M. O. Horsanali, E. Deveci, E. Dil, and A. Yilmaz. 2018. The protective effect of astaxanthin against cisplatin-induced nephrotoxicity in rats. Biomedicine & Pharmacotherapy 100:575–82. doi: 10.1016/j.biopha.2018.02.042.
   PubMed Web of Science ®Google Scholar
• Al-Amin, M. M., S. Akhter, A. T. Hasan, T. Alam, S. M. Nageeb Hasan, A. R. Saifullah, and M. Shohel. 2015. The antioxidant effect of astaxanthin is higher in young mice than aged: A region specific study on brain. Metabolic Brain Disease 30 (5):1237–46. doi: 10.1007/s11011-015-9699-4.
   PubMed Web of Science ®Google Scholar
• Al-Amin, M. M., W. Mahmud, M. S. Pervin, S. M. Ridwanul Islam, M. Ashikur Rahman, and A. Zinchenko. 2019. Astaxanthin ameliorates scopolamine-induced spatial memory deficit via reduced cortical-striato-hippocampal oxidative stress. Brain Research 1710:74–81. doi: 10.1016/j.brainres.2018.12.014.
   PubMed Web of Science ®Google Scholar
• Alam, I., A. M. Almajwal, W. Alam, I. Alam, N. Ullah, M. Abulmeaaty, S. Razak, S. Khan, G. Pawelec, and P. I. Paracha. 2019. The immune-nutrition interplay in aging–facts and controversies. Nutrition and Healthy Aging 5 (2):73–95. doi: 10.3233/NHA-170034.
   Google Scholar
• Alam, M. N., M. M. Hossain, M. M. Rahman, N. Subhan, M. A. A. Mamun, A. Ulla, H. M. Reza, and M. A. Alam. 2018. Astaxanthin prevented oxidative stress in heart and kidneys of isoproterenol-administered aged rats. Journal of Dietary Supplements 15 (1):42–54. doi: 10.1080/19390211.2017.1321078.
   PubMedGoogle Scholar
• Alam, S., G. Mustafa, M. Alam, and N. Ahmad. 2016. Insulin resistance in development and progression of nonalcoholic fatty liver disease. World Journal of Gastrointestinal Pathophysiology 7 (2):211–7. doi: 10.4291/wjgp.v7.i2.211.
   PubMedGoogle Scholar
• Alex, M., M. V. Sauganth Paul, M. Abhilash, V. V. Mathews, T. V. Anilkumar, and R. H. Nair. 2014. Astaxanthin modulates osteopontin and transforming growth factor β1 expression levels in a rat model of nephrolithiasis: A comparison with citrate administration. BJU International 114 (3):458–66. doi: 10.1111/bju.12537.
   PubMed Web of Science ®Google Scholar
• Alghazwi, M., S. Smid, I. Musgrave, and W. Zhang. 2019. In vitro studies of the neuroprotective activities of astaxanthin and fucoxanthin against amyloid beta (Aβ1-42) toxicity and aggregation. Neurochemistry International 124:215–24. doi: 10.1016/j.neuint.2019.01.010.
   PubMed Web of Science ®Google Scholar
• Alves, A., E. Sousa, A. Kijjoa, and M. Pinto. 2020. Marine-derived compounds with potential use as cosmeceuticals and nutricosmetics. Molecules 25 (11):2536. doi: 10.3390/molecules25112536.
   PubMed Web of Science ®Google Scholar
• Ambati, R. R., S. M. Phang, S. Ravi, and R. G. Aswathanarayana. 2014. Astaxanthin: Sources, extraction, stability, biological activities and its commercial applications—A review. Marine Drugs 12 (1):128–52. doi: 10.3390/md12010128.
   PubMed Web of Science ®Google Scholar
• Andersen, L. P., S. Holck, L. Kupcinskas, G. Kiudelis, L. Jonaitis, D. Janciauskas, H. Permin, and T. Wadström. 2007. Gastric inflammatory markers and interleukins in patients with functional dyspepsia treated with astaxanthin. FEMS Immunology and Medical Microbiology 50 (2):244–8. doi: 10.1111/j.1574-695X.2007.00257.x.
   PubMedGoogle Scholar
• Anderson, M. L. 2005. A preliminary investigation of the enzymatic inhibition of 5alpha-reduction and growth of prostatic carcinoma cell line LNCap-FGC by natural astaxanthin and Saw Palmetto lipid extract in vitro. Journal of Herbal Pharmacotherapy 5 (1):17–26. doi: 10.1080/J157v05n01_03.
   PubMedGoogle Scholar
• Andreucci, M., T. Faga, A. Pisani, M. Sabbatini, and A. Michael. 2014. Acute kidney injury by radiographic contrast media: Pathogenesis and prevention. BioMed Research International 2014:362725. doi: 10.1155/2014/362725.
   PubMed Web of Science ®Google Scholar
• Andrisani, A., G. Donà, E. Tibaldi, A. M. Brunati, C. Sabbadin, D. Armanini, G. Alvisi, S. Gizzo, G. Ambrosini, E. Ragazzi, et al. 2015. Astaxanthin improves human sperm capacitation by inducing lyn displacement and activation. Marine Drugs 13 (9):5533–51. doi: 10.3390/md13095533.
   PubMed Web of Science ®Google Scholar
• Angwafor, F., III, and M. L. Anderson. 2008. An open label, dose response study to determine the effect of a dietary supplement on dihydrotestosterone, testosterone and estradiol levels in healthy males. Journal of the International Society of Sports Nutrition 5:12. doi: 10.1186/1550-2783-5-12.
   PubMed Web of Science ®Google Scholar
• Ao, X., and I. Kim. 2019. Effects of astaxanthin produced by Phaffia rhodozyma on growth performance, antioxidant activities, and meat quality in Pekin ducks. Poultry Science 98 (10):4954–60. doi: 10.3382/ps/pez256.
   PubMed Web of Science ®Google Scholar
• Aoi, W., T. Maoka, R. Abe, M. Fujishita, and K. Tominaga. 2018. Comparison of the effect of non-esterified and esterified astaxanthins on endurance performance in mice. Journal of Clinical Biochemistry and Nutrition 62 (2):161–6. doi: 10.3164/jcbn.17-89.
   PubMed Web of Science ®Google Scholar
• Aoi, W., Y. Naito, K. Sakuma, M. Kuchide, H. Tokuda, T. Maoka, S. Toyokuni, S. Oka, M. Yasuhara, and T. Yoshikawa. 2003. Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in mice. Antioxidants & Redox Signaling 5 (1):139–44. doi: 10.1089/152308603321223630.
   PubMed Web of Science ®Google Scholar
• Aoi, W., Y. Naito, Y. Takanami, T. Ishii, Y. Kawai, S. Akagiri, Y. Kato, T. Osawa, and T. Yoshikawa. 2008. Astaxanthin improves muscle lipid metabolism in exercise via inhibitory effect of oxidative CPT I modification. Biochemical and Biophysical Research Communications 366 (4):892–7. doi: 10.1016/j.bbrc.2007.12.019.
   PubMed Web of Science ®Google Scholar
• Arslan, E., H. Turk, M. Caglayan, T. T. Turkmenoglu, A. Gonel, and C. Tayman. 2021. Protective effects of astaxanthin on nephrotoxicity in rats with induced renovascular occlusion. Combinatorial Chemistry & High Throughput Screening 24 (8):1236–42. doi: 10.2174/1386207323666200914104432.
   PubMed Web of Science ®Google Scholar
• Atalay, P. B., G. Kuku, and B. G. Tuna. 2019. Effects of carbendazim and astaxanthin co-treatment on the proliferation of MCF-7 breast cancer cells. In Vitro Cellular & Developmental Biology. Animal 55 (2):113–9. doi: 10.1007/s11626-018-0312-0.
   PubMed Web of Science ®Google Scholar
• Atianand, M. K., W. Hu, A. T. Satpathy, Y. Shen, E. P. Ricci, J. R. Alvarez-Dominguez, A. Bhatta, S. A. Schattgen, J. D. McGowan, J. Blin, et al. 2016. A long noncoding RNA lincRNA-EPS acts as a transcriptional brake to restrain inflammation. Cell 165 (7):1672–85. doi: 10.1016/j.cell.2016.05.075.
   PubMed Web of Science ®Google Scholar
• Babic, T. 1999. The cholinergic hypothesis of Alzheimer’s disease: A review of progress. Journal of Neurology, Neurosurgery, and Psychiatry 67 (4):558. doi: 10.1136/jnnp.67.4.558.
   PubMed Web of Science ®Google Scholar
• Bae, M., M. B. Kim, H. Kang, Y. K. Park, and J. Y. Lee. 2019a. Comparison of carotenoids for their antifibrogenic effects in hepatic stellate cells. Lipids 54 (6-7):401–10. doi: 10.1002/lipd.12157.
   PubMed Web of Science ®Google Scholar
• Bae, M., Y. Lee, Y. K. Park, D. G. Shin, P. Joshi, S. H. Hong, N. Alder, S. I. Koo, and J. Y. Lee. 2019b. Astaxanthin attenuates the increase in mitochondrial respiration during the activation of hepatic stellate cells. The Journal of Nutritional Biochemistry 71:82–9. doi: 10.1016/j.jnutbio.2019.06.001.
   PubMed Web of Science ®Google Scholar
• Bae, M., Y. Lee, T. X. Pham, S. Hu, Y. K. Park, and J. Y. Lee. 2020. Astaxanthin inhibits the reduction of glycolysis during the activation of hepatic stellate cells. Life Sciences 256:117926. doi: 10.1016/j.lfs.2020.117926.
   PubMed Web of Science ®Google Scholar
• Bae, M., Y. K. Park, and J. Y. Lee. 2018. Food components with antifibrotic activity and implications in prevention of liver disease. The Journal of Nutritional Biochemistry 55:1–11. doi: 10.1016/j.jnutbio.2017.11.003.
   PubMed Web of Science ®Google Scholar
• Beitz, J. M. 2014. Parkinson’s disease: A review. Frontiers in Bioscience (Scholar Edition) 6 (1):65–74. doi: 10.2741/s415.
   PubMedGoogle Scholar
• Bennedsen, M., X. Wang, R. Willén, T. Wadström, and L. P. Andersen. 1999. Treatment of H. pylori infected mice with antioxidant astaxanthin reduces gastric inflammation, bacterial load and modulates cytokine release by splenocytes. Immunology Letters 70 (3):185–9. doi: 10.1016/S0165-2478(99)00145-5.
   PubMed Web of Science ®Google Scholar
• Berge, K., B. Robertson, and L. Burri. 2015. Safety assessment of Superba™ krill powder: Subchronic toxicity study in rats. Toxicology Reports 2:144–51. doi: 10.1016/j.toxrep.2014.11.011.
   PubMedGoogle Scholar
• Bertram, J. S., and A. L. Vine. 2005. Cancer prevention by retinoids and carotenoids: Independent action on a common target. Biochimica et Biophysica Acta 1740 (2):170–8. doi: 10.1016/j.bbadis.2005.01.003.
   PubMed Web of Science ®Google Scholar
• Bharathiraja, S., P. Manivasagan, N. Quang Bui, Y. O. Oh, I. G. Lim, S. Park, and J. Oh. 2016. Cytotoxic induction and photoacoustic imaging of breast cancer cells using astaxanthin-reduced gold nanoparticles. Nanomaterials 6 (4):78. doi: 10.3390/nano6040078.
   Web of Science ®Google Scholar
• Bidaran, S., A. R. Ahmadi, P. Yaghmaei, M. H. Sanati, and A. Ebrahim-Habibi. 2018. Astaxanthin effectiveness in preventing multiple sclerosis in animal model. Bratislavske Lekarske Listy 119 (3):160–6. doi: 10.4149/bll_2018_031.
   PubMed Web of Science ®Google Scholar
• Bloomer, R. J. 2007. The role of nutritional supplements in the prevention and treatment of resistance exercise-induced skeletal muscle injury. Sports Medicine 37 (6):519–32. doi: 10.2165/00007256-200737060-00005.
   PubMed Web of Science ®Google Scholar
• Briggs, R., S. P. Kennelly, and D. O’Neill. 2016. Drug treatments in Alzheimer’s disease. Clinical Medicine 16 (3):247–53. doi: 10.7861/clinmedicine.16-3-247.
   PubMed Web of Science ®Google Scholar
• Brotman, R. G. M. C. Moreno-Escobar, J. Joseph, and G. Pawar. 2022. Amyotrophic lateral sclerosis. Treasure Island, FL: StatPearls.
   Google Scholar
• Brotosudarmo, T. H. P., L. Limantara, E. Setiyono, and Heriyanto. 2020. Structures of astaxanthin and their consequences for therapeutic application. International Journal of Food Science 2020:2156582. doi: 10.1155/2020/2156582.
   PubMedGoogle Scholar
• Cakir, E., U. Cakir, C. Tayman, T. T. Turkmenoglu, A. Gonel, and I. O. Turan. 2020. Favorable effects of astaxanthin on brain damage due to ischemia—Reperfusion injury. Combinatorial Chemistry & High Throughput Screening 23 (3):214–24. doi: 10.2174/1386207323666200219121600.
   PubMed Web of Science ®Google Scholar
• Camera, E., A. Mastrofrancesco, C. Fabbri, F. Daubrawa, M. Picardo, H. Sies, and W. Stahl. 2009. Astaxanthin, canthaxanthin and beta-carotene differently affect UVA-induced oxidative damage and expression of oxidative stress-responsive enzymes. Experimental Dermatology 18 (3):222–31. doi: 10.1111/j.1600-0625.2008.00790.x.
   PubMed Web of Science ®Google Scholar
• Capelli, B., D. Bagchi, and G. Cysewski. 2013. Synthetic astaxanthin is significantly inferior to algal-based astaxanthin as an antioxidant and may not be suitable as a human nutraceutical supplement. Nutrafoods 12 (4):145–52. doi: 10.1007/s13749-013-0051-5.
   Google Scholar
• Carulli, C. E. Luzi, A. Macera, M. Innocenti, and M. L. Brandi. 2015. Chapter 40—RNA-based therapies for bone diseases. In MicroRNA in regenerative medicine, ed. C. K. Sen, 1049–73. Oxford: Academic Press. doi: 10.1016/B978-0-12-405544-5.00040-X.
   Google Scholar
• Chalyk, N. E., V. A. Klochkov, T. Y. Bandaletova, N. H. Kyle, and I. M. Petyaev. 2017. Continuous astaxanthin intake reduces oxidative stress and reverses age-related morphological changes of residual skin surface components in middle-aged volunteers. Nutrition Research 48:40–8. doi: 10.1016/j.nutres.2017.10.006.
   PubMed Web of Science ®Google Scholar
• Chang, C. H., C. Y. Chen, J. Y. Chiou, R. Y. Peng, and C. H. Peng. 2010. Astaxanthine secured apoptotic death of PC12 cells induced by beta-amyloid peptide 25-35: Its molecular action targets. Journal of Medicinal Food 13 (3):548–56. doi: 10.1089/jmf.2009.1291.
   PubMed Web of Science ®Google Scholar
• Chang, X., L. Xing, Y. Wang, C. X. Yang, Y. J. He, T. J. Zhou, X. D. Gao, L. Li, H. P. Hao, and H. L. Jiang. 2020. Monocyte-derived multipotent cell delivered programmed therapeutics to reverse idiopathic pulmonary fibrosis. Science Advances 6 (22):eaba3167. doi: 10.1126/sciadv.aba3167.
   PubMed Web of Science ®Google Scholar
• Che, H., Q. Li, T. Zhang, D. Wang, L. Yang, J. Xu, T. Yanagita, C. Xue, Y. Chang, and Y. Wang. 2018. Effects of astaxanthin and docosahexaenoic-acid-acylated astaxanthin on Alzheimer’s disease in APP/PS1 double-transgenic mice. Journal of Agricultural and Food Chemistry 66 (19):4948–57. doi: 10.1021/acs.jafc.8b00988.
   PubMed Web of Science ®Google Scholar
• Chen, H., J. Wang, R. Li, C. Lv, P. Xu, Y. Wang, X. Song, and J. Zhang. 2020. Astaxanthin attenuates pulmonary fibrosis through lncITPF and mitochondria-mediated signal pathways. Journal of Cellular and Molecular Medicine 24 (17):10245–50. doi: 10.1111/jcmm.15477.
   PubMed Web of Science ®Google Scholar
• Chen, J. C., C. H. Wu, Y. S. Peng, H. Y. Zheng, Y. C. Lin, P. F. Ma, T. C. Yen, T. Y. Chen, and Y. W. Lin. 2018. Astaxanthin enhances erlotinib-induced cytotoxicity by p38 MAPK mediated xeroderma pigmentosum complementation group C (XPC) down-regulation in human lung cancer cells. Toxicology Research 7 (6):1247–56. doi: 10.1039/c7tx00292k.
   Web of Science ®Google Scholar
• Chen, Q., J. Tao, G. Li, D. Zheng, Y. Tan, R. Li, L. Tian, Z. Li, H. Cheng, and X. Xie. 2018. Astaxanthin ameliorates experimental diabetes-induced renal oxidative stress and fibronectin by upregulating connexin43 in glomerular mesangial cells and diabetic mice. European Journal of Pharmacology 840:33–43. doi: 10.1016/j.ejphar.2018.09.028.
   PubMed Web of Science ®Google Scholar
• Chen, W. P., Y. Xiong, Y. X. Shi, P. F. Hu, J. P. Bao, and L. D. Wu. 2014. Astaxanthin reduces matrix metalloproteinase expression in human chondrocytes. International Immunopharmacology 19 (1):174–7. doi: 10.1016/j.intimp.2013.12.007.
   PubMed Web of Science ®Google Scholar
• Chen, Y. Y., P. C. Lee, Y. L. Wu, and L. Y. Liu. 2015. In vivo effects of free form astaxanthin powder on anti-oxidation and lipid metabolism with high-cholesterol diet. PLoS One 10 (8):e0134733. doi: 10.1371/journal.pone.0134733.
   PubMed Web of Science ®Google Scholar
• Chen, Z., W. Li, L. Shi, L. Jiang, M. Li, C. Zhang, and H. Peng. 2020. Kidney-targeted astaxanthin natural antioxidant nanosystem for diabetic nephropathy therapy. European Journal of Pharmaceutics and Biopharmaceutics 156:143–54. doi: 10.1016/j.ejpb.2020.09.005.
   PubMed Web of Science ®Google Scholar
• Chen, Z., J. Xiao, H. Liu, K. Yao, X. Hou, Y. Cao, and X. Liu. 2020. Astaxanthin attenuates oxidative stress and immune impairment in D-galactose-induced aging in rats by activating the Nrf2/Keap1 pathway and suppressing the NF-κB pathway. Food & Function 11 (9):8099–111. doi: 10.1039/d0fo01663b.
   PubMed Web of Science ®Google Scholar
• Cheresh, P., S. J. Kim, S. Tulasiram, and D. W. Kamp. 2013. Oxidative stress and pulmonary fibrosis. Biochimica et Biophysica Acta 1832 (7):1028–40. doi: 10.1016/j.bbadis.2012.11.021.
   PubMed Web of Science ®Google Scholar
• Cherian, A., and S. V. Thomas. 2009. Status epilepticus. Annals of Indian Academy of Neurology 12 (3):140–53. doi: 10.4103/0972-2327.56312.
   PubMed Web of Science ®Google Scholar
• Chew, B. P., J. S. Park, M. W. Wong, and T. S. Wong. 1999. A comparison of the anticancer activities of dietary beta-carotene, canthaxanthin and astaxanthin in mice in vivo. Anticancer Research 19 (3A):1849–53.
   PubMed Web of Science ®Google Scholar
• Choi, H. D., H. E. Kang, S. H. Yang, M. G. Lee, and W. G. Shin. 2011. Pharmacokinetics and first-pass metabolism of astaxanthin in rats. The British Journal of Nutrition 105 (2):220–7. doi: 10.1017/S0007114510003454.
   PubMed Web of Science ®Google Scholar
• Chou, H. Y., C. Lee, J. L. Pan, Z. H. Wen, S. H. Huang, C. W. Lan, W. T. Liu, T. C. Hour, Y. C. Hseu, B. H. Hwang, et al. 2016. Enriched astaxanthin extract from Haematococcus pluvialis augments growth factor secretions to increase cell proliferation and induces MMP1 degradation to enhance collagen production in human dermal fibroblasts. International Journal of Molecular Sciences 17 (6):955. doi: 10.3390/ijms17060955.
   PubMed Web of Science ®Google Scholar
• Clugston, R. D. 2020. Carotenoids and fatty liver disease: Current knowledge and research gaps. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids 1865 (11):158597. doi: 10.1016/j.bbalip.2019.158597.
   PubMed Web of Science ®Google Scholar
• Collier, T. J., N. M. Kanaan, and J. H. Kordower. 2011. Ageing as a primary risk factor for Parkinson’s disease: Evidence from studies of non-human primates. Nature Reviews. Neuroscience 12 (6):359–66. doi: 10.1038/nrn3039.
   PubMed Web of Science ®Google Scholar
• Collier, T. J., N. M. Kanaan, and J. H. Kordower. 2017. Aging and Parkinson’s disease: Different sides of the same coin? Movement Disorders 32 (7):983–90. doi: 10.1002/mds.27037.
   PubMed Web of Science ®Google Scholar
• Comhaire, F. H., Y. E. Garem, A. Mahmoud, F. Eertmans, and F. Schoonjans. 2005. Combined conventional/antioxidant "Astaxanthin" treatment for male infertility: A double blind, randomized trial. Asian Journal of Andrology 7 (3):257–62. doi: 10.1111/j.1745-7262.2005.00047.x.
   PubMed Web of Science ®Google Scholar
• Congdon, E. E., and E. M. Sigurdsson. 2018. Tau-targeting therapies for Alzheimer disease. Nature Reviews. Neurology 14 (7):399–415. doi: 10.1038/s41582-018-0013-z.
   PubMed Web of Science ®Google Scholar
• Coral-Hinostroza, G. N., T. Ytrestøyl, B. Ruyter, and B. Bjerkeng. 2004. Plasma appearance of unesterified astaxanthin geometrical E/Z and optical R/S isomers in men given single doses of a mixture of optical 3 and 3’R/S isomers of astaxanthin fatty acyl diesters. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 139 (1-3):99–110. doi: 10.1016/j.cca.2004.09.011.
   PubMed Web of Science ®Google Scholar
• Cristina, N. M., and d A. Lucia. 2021. Nutrition and healthy aging: Prevention and treatment of gastrointestinal diseases. Nutrients 13 (12):4337. doi: 10.3390/nu13124337.
   PubMed Web of Science ®Google Scholar
• Cui, G., L. Li, W. Xu, M. Wang, D. Jiao, B. Yao, K. Xu, Y. Chen, S. Yang, M. Long, et al. 2020. Astaxanthin protects ochratoxin A-induced oxidative stress and apoptosis in the heart via the Nrf2 pathway. Oxidative Medicine and Cellular Longevity 2020:7639109. doi: 10.1155/2020/7639109.
   PubMed Web of Science ®Google Scholar
• Cunningham, E. L., B. McGuinness, B. Herron, and A. P. Passmore. 2015. Dementia. The Ulster Medical Journal 84 (2):79–87.
   PubMedGoogle Scholar
• Curek, G. D., A. Cort, G. Yucel, N. Demir, S. Ozturk, G. O. Elpek, B. Savas, and M. Aslan. 2010. Effect of astaxanthin on hepatocellular injury following ischemia/reperfusion. Toxicology 267 (1-3):147–53. doi: 10.1016/j.tox.2009.11.003.
   PubMed Web of Science ®Google Scholar
• Dao, M. C., A. Everard, J. Aron-Wisnewsky, N. Sokolovska, E. Prifti, E. O. Verger, B. D. Kayser, F. Levenez, J. Chilloux, L. Hoyles, et al. 2016. Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: Relationship with gut microbiome richness and ecology. Gut 65 (3):426–36. doi: 10.1136/gutjnl-2014-308778.
   PubMed Web of Science ®Google Scholar
• Daubrawa, F., H. Sies, and W. Stahl. 2005. Astaxanthin diminishes gap junctional intercellular communication in primary human fibroblasts. The Journal of Nutrition 135 (11):2507–11. doi: 10.1093/jn/135.11.2507.
   PubMed Web of Science ®Google Scholar
• Davinelli, S., H. M. Melvang, L. P. Andersen, G. Scapagnini, and M. E. Nielsen. 2019. Astaxanthin from shrimp cephalothorax stimulates the immune response by enhancing IFN-γ, IL-10, and IL-2 secretion in splenocytes of Helicobacter pylori-infected mice. Marine Drugs 17 (7):382. doi: 10.3390/md17070382.
   PubMed Web of Science ®Google Scholar
• Dehghani, M., R. Jalal, and M. R. Rashidi. 2021. Kinetic and thermodynamic insights into the interaction of Aβ1-42 with astaxanthin and aggregation behavior of Aβ1-42: Surface plasmon resonance, microscopic, and molecular docking studies. Biophysical Chemistry 275:106612. doi: 10.1016/j.bpc.2021.106612.
   PubMed Web of Science ®Google Scholar
• Del Zoppo, G. J., J. L. Saver, E. C. Jauch, H. P. Adams, Jr., and American Heart Association Stroke Council. 2009. Expansion of the time window for treatment of acute ischemic stroke with intravenous tissue plasminogen activator: A science advisory from the American Heart Association/American Stroke Association. Stroke 40 (8):2945–8. doi: 10.1161/strokeaha.109.192535.
   PubMed Web of Science ®Google Scholar
• Deng, X., M. Wang, S. Hu, Y. Feng, Y. Shao, Y. Xie, M. Wu, Y. Chen, and X. Shi. 2019. The neuroprotective effect of astaxanthin on pilocarpine-induced status epilepticus in rats. Frontiers in Cellular Neuroscience 13:123. doi: 10.3389/fncel.2019.00123.
   PubMed Web of Science ®Google Scholar
• Deshmukh, P., S. Unni, G. Krishnappa, and B. Padmanabhan. 2017. The Keap1-Nrf2 pathway: Promising therapeutic target to counteract ROS-mediated damage in cancers and neurodegenerative diseases. Biophysical Reviews 9 (1):41–56. doi: 10.1007/s12551-016-0244-4.
   PubMedGoogle Scholar
• Dhanjal, D. S., S. Bhardwaj, R. Sharma, K. Bhardwaj, D. Kumar, C. Chopra, E. Nepovimova, R. Singh, and K. Kuca. 2020. Plant fortification of the diet for anti-ageing effects: A review. Nutrients 12 (10):3008. doi: 10.3390/nu12103008.
   PubMed Web of Science ®Google Scholar
• Di Virgilio, F., D. Dal Ben, A. C. Sarti, A. L. Giuliani, and S. Falzoni. 2017. The P2X7 receptor in infection and inflammation. Immunity 47 (1):15–31. doi: 10.1016/j.immuni.2017.06.020.
   PubMed Web of Science ®Google Scholar
• Diao, W., W. Chen, W. Cao, H. Yuan, H. Ji, T. Wang, W. Chen, X. Zhu, H. Zhou, H. Guo, et al. 2019. Astaxanthin protects against renal fibrosis through inhibiting myofibroblast activation and promoting CD8+ T cell recruitment. Biochimica et Biophysica Acta. General Subjects 1863 (9):1360–70. doi: 10.1016/j.bbagen.2019.05.020.
   PubMed Web of Science ®Google Scholar
• Djordjevic, B., I. Baralic, J. Kotur-Stevuljevic, A. Stefanovic, J. Ivanisevic, N. Radivojevic, M. Andjelkovic, and N. Dikic. 2012. Effect of astaxanthin supplementation on muscle damage and oxidative stress markers in elite young soccer players. The Journal of Sports Medicine and Physical Fitness 52 (4):382–92.
   PubMed Web of Science ®Google Scholar
• Do, L. T., V. V. Luu, Y. Morita, M. Taniguchi, M. Nii, A. T. Peter, and T. Otoi. 2015. Astaxanthin present in the maturation medium reduces negative effects of heat shock on the developmental competence of porcine oocytes. Reproductive Biology 15 (2):86–93. doi: 10.1016/j.repbio.2015.01.002.
   PubMed Web of Science ®Google Scholar
• Dokumacioglu, E., H. Iskender, G. Yenice, K. A. T. Kapakin, C. Sevim, A. Hayirli, S. Saral, and S. Comakli. 2018. Effects of astaxanthin on biochemical and histopathological parameters related to oxidative stress on testes of rats on high fructose regime. Andrologia 50 (7):e13042. doi: 10.1111/and.13042.
   PubMed Web of Science ®Google Scholar
• Dominguez, L. J., N. Veronese, E. Baiamonte, M. Guarrera, A. Parisi, C. Ruffolo, F. Tagliaferri, and M. Barbagallo. 2022. Healthy aging and dietary patterns. Nutrients 14 (4):889. doi: 10.3390/nu14040889.
   PubMed Web of Science ®Google Scholar
• Donà, G., I. Kožuh, A. M. Brunati, A. Andrisani, G. Ambrosini, G. Bonanni, E. Ragazzi, D. Armanini, G. Clari, and L. Bordin. 2013. Effect of astaxanthin on human sperm capacitation. Marine Drugs 11 (6):1909–19. doi: 10.3390/md11061909.
   PubMed Web of Science ®Google Scholar
• Dong, L. Y., J. Jin, G. Lu, and X. L. Kang. 2013. Astaxanthin attenuates the apoptosis of retinal ganglion cells in db/db mice by inhibition of oxidative stress. Marine Drugs 11 (3):960–74. doi: 10.3390/md11030960.
   PubMed Web of Science ®Google Scholar
• Drill, M., N. C. Jones, M. Hunn, T. J. O’Brien, and M. Monif. 2021. Antagonism of the ATP-gated P2X7 receptor: A potential therapeutic strategy for cancer. Purinergic Signalling 17 (2):215–27. doi: 10.1007/s11302-021-09776-9.
   PubMed Web of Science ®Google Scholar
• EFSA Panel on Dietetic Products and Allergies. 2014. Scientific opinion on the safety of astaxanthin‐rich ingredients (AstaREAL A1010 and AstaREAL L10) as novel food ingredients. EFSA Journal 12 (7):3757.
   Google Scholar
• EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck, D., J. Castenmiller, S. de Henauw, K. I. Hirsch‐Ernst, J. Kearney, A. Maciuk, I. Mangelsdorf, H. J. McArdle, A. Naska, C. Pelaez, et al. 2020. Safety of astaxanthin for its use as a novel food in food supplements. EFSA Journal 18 (2):e05993. doi: 10.2903/j.efsa.2020.5993.
   PubMed Web of Science ®Google Scholar
• El-Baz, F. K., R. A. Hussein, G. A. R. Abdel Jaleel, and D. O. Saleh. 2018. Astaxanthin-rich Haematococcus pluvialis algal hepatic modulation in D-galactose-induced aging in rats: Role of Nrf2. Advanced Pharmaceutical Bulletin 8 (3):523–8. doi: 10.15171/apb.2018.061.
   PubMed Web of Science ®Google Scholar
• El-Baz, F. K., D. O. Saleh, G. A. Abdel Jaleel, R. A. Hussein, and A. Hassan. 2019. Heamatococcus pluvialis ameliorates bone loss in experimentally-induced osteoporosis in rats via the regulation of OPG/RANKL pathway. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 116:109017. doi: 10.1016/j.biopha.2019.109017.
   PubMed Web of Science ®Google Scholar
• Emanueli, C., M. B. Salis, A. Pinna, T. Stacca, A. F. Milia, A. Spano, J. Chao, L. Chao, L. Sciola, and P. Madeddu. 2002. Prevention of diabetes-induced microangiopathy by human tissue kallikrein gene transfer. Circulation 106 (8):993–9. doi: 10.1161/01.cir.0000027104.33206.c8.
   PubMed Web of Science ®Google Scholar
• Fan, C. D., J. Y. Sun, X. T. Fu, Y. J. Hou, Y. Li, M. F. Yang, X. Y. Fu, and B. L. Sun. 2017. Astaxanthin attenuates homocysteine-induced cardiotoxicity in vitro and in vivo by inhibiting mitochondrial dysfunction and oxidative damage. Frontiers in Physiology 8:1041. doi: 10.3389/fphys.2017.01041.
   PubMed Web of Science ®Google Scholar
• Fan, K. W, and F. Chen. 2007. Chapter 11—Production of high-value products by marine microalgae thraustochytrids. In Bioprocessing for value-added products from renewable resources, ed. Shang-Tian Yang, 293–323. Amsterdam: Elsevier. doi: 10.1016/B978-044452114-9/50012-8.
   Google Scholar
• Fang, Q., S. Guo, H. Zhou, R. Han, P. Wu, and C. Han. 2017. Astaxanthin protects against early burn-wound progression in rats by attenuating oxidative stress-induced inflammation and mitochondria-related apoptosis. Scientific Reports 7:41440. doi: 10.1038/srep41440.
   PubMed Web of Science ®Google Scholar
• Farmer, J. A. 1998. Aggressive lipid therapy in the statin era. Progress in Cardiovascular Diseases 41 (2):71–94. doi: 10.1016/S0033-0620(98)80006-6.
   PubMed Web of Science ®Google Scholar
• Farrell, R. J., and M. A. Peppercorn. 2002. Ulcerative colitis. Lancet 359 (9303):331–40. doi: 10.1016/S0140-6736(02)07499-8.
   PubMed Web of Science ®Google Scholar
• Feng, Y., A. Chu, Q. Luo, M. Wu, X. Shi, and Y. Chen. 2018. The protective effect of astaxanthin on cognitive function via inhibition of oxidative stress and inflammation in the brains of chronic T2DM rats. Frontiers in Pharmacology 9:748. doi: 10.3389/fphar.2018.00748.
   PubMed Web of Science ®Google Scholar
• Ferreira-Vieira, T. H., I. M. Guimaraes, F. R. Silva, and F. M. Ribeiro. 2016. Alzheimer’s disease: Targeting the cholinergic system. Current Neuropharmacology 14 (1):101–15. doi: 10.2174/1570159x13666150716165726.
   PubMed Web of Science ®Google Scholar
• Foss, P. A., B. Renstrøm, and S. v. Liaaen-Jensen. 1987. Natural occurrence of enantiomeric and meso astaxanthin Y-crustaceans including zooplankton. Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 86 (2):313–4. doi: 10.1016/0305-0491(87)90298-7.
   PubMed Web of Science ®Google Scholar
• Fu, J., H. Sun, H. Wei, M. Dong, Y. Zhang, W. Xu, Y. Fang, and J. Zhao. 2020. Astaxanthin alleviates spinal cord ischemia-reperfusion injury via activation of PI3K/Akt/GSK-3β pathway in rats. Journal of Orthopaedic Surgery and Research 15 (1):275. doi: 10.1186/s13018-020-01790-8.
   PubMed Web of Science ®Google Scholar
• Fu, M., X. Zhang, X. Zhang, L. Yang, S. Luo, and H. Liu. 2021. Autophagy plays a role in the prolongation of the life span of Caenorhabditis elegans by astaxanthin. Rejuvenation Research 24 (3):198–205. doi: 10.1089/rej.2020.2355.
   PubMed Web of Science ®Google Scholar
• Gandhi, R., A. Laroni, and H. L. Weiner. 2010. Role of the innate immune system in the pathogenesis of multiple sclerosis. Journal of Neuroimmunology 221 (1-2):7–14. doi: 10.1016/j.jneuroim.2009.10.015.
   PubMed Web of Science ®Google Scholar
• Gao, D., H. Wang, Y. Xu, D. Zheng, Q. Zhang, and W. Li. 2019. Protective effect of astaxanthin against contrast-induced acute kidney injury via SIRT1-p53 pathway in rats. International Urology and Nephrology 51 (2):351–8. doi: 10.1007/s11255-018-2027-2.
   PubMed Web of Science ®Google Scholar
• Ghasemi, N. 2018. The evaluation of astaxanthin effects on differentiation of human adipose derived stem cells into oligodendrocyte precursor cells. Avicenna Journal of Medical Biotechnology 10 (2):69–74.
   PubMedGoogle Scholar
• Ghasemi, N., S. Razavi, and E. Nikzad. 2017. Multiple sclerosis: Pathogenesis, symptoms, diagnoses and cell-based therapy. Cell Journal 19 (1):1–10. doi: 10.22074/cellj.2016.4867.
   PubMed Web of Science ®Google Scholar
• Ghlissi, Z., A. Hakim, A. Sila, H. Mnif, K. Zeghal, T. Rebai, A. Bougatef, and Z. Sahnoun. 2014. Evaluation of efficacy of natural astaxanthin and vitamin E in prevention of colistin-induced nephrotoxicity in the rat model. Environmental Toxicology and Pharmacology 37 (3):960–6. doi: 10.1016/j.etap.2014.03.004.
   PubMed Web of Science ®Google Scholar
• Godoy-Matos, A. F., W. S. Silva Júnior, and C. M. Valerio. 2020. NAFLD as a continuum: From obesity to metabolic syndrome and diabetes. Diabetology & Metabolic Syndrome 12 (1):60. doi: 10.1186/s13098-020-00570-y.
   PubMed Web of Science ®Google Scholar
• Golabi, P., J. Paik, R. Reddy, E. Bugianesi, G. Trimble, and Z. M. Younossi. 2019. Prevalence and long-term outcomes of non-alcoholic fatty liver disease among elderly individuals from the United States. BMC Gastroenterology 19 (1):56. doi: 10.1186/s12876-019-0972-6.
   PubMedGoogle Scholar
• Green, L. K., and D. Y. Graham. 1990. Gastritis in the elderly. Gastroenterology Clinics of North America 19 (2):273–92. doi: 10.1016/S0889-8553(21)00497-0.
   PubMed Web of Science ®Google Scholar
• Grimmig, B., L. Daly, M. Subbarayan, C. Hudson, R. Williamson, K. Nash, and P. C. Bickford. 2018. Astaxanthin is neuroprotective in an aged mouse model of Parkinson’s disease. Oncotarget 9 (12):10388–401. doi: 10.18632/oncotarget.23737.
   PubMedGoogle Scholar
• Grimmig, B., C. Hudson, L. Moss, M. Peters, M. Subbarayan, E. J. Weeber, and P. C. Bickford. 2019. Astaxanthin supplementation modulates cognitive function and synaptic plasticity in young and aged mice. GeroScience 41 (1):77–87. doi: 10.1007/s11357-019-00051-9.
   PubMed Web of Science ®Google Scholar
• Grimmig, B., J. Morganti, K. Nash, and P. C. Bickford. 2016. Immunomodulators as therapeutic agents in mitigating the progression of Parkinson’s disease. Brain Sciences 6 (4):41. doi: 10.3390/brainsci6040041.
   PubMed Web of Science ®Google Scholar
• Gross, G. J., and S. F. Lockwood. 2004. Cardioprotection and myocardial salvage by a disodium disuccinate astaxanthin derivative (Cardax). Life Sciences 75 (2):215–24. doi: 10.1016/j.lfs.2003.12.006.
   PubMed Web of Science ®Google Scholar
• Gross, G. J., and S. F. Lockwood. 2005. Acute and chronic administration of disodium disuccinate astaxanthin (Cardax) produces marked cardioprotection in dog hearts. Molecular and Cellular Biochemistry 272 (1-2):221–7. doi: 10.1007/s11010-005-7555-2.
   PubMed Web of Science ®Google Scholar
• Guo, S. X., H. L. Zhou, C. L. Huang, C. G. You, Q. Fang, P. Wu, X. G. Wang, and C. M. Han. 2015. Astaxanthin attenuates early acute kidney injury following severe burns in rats by ameliorating oxidative stress and mitochondrial-related apoptosis. Marine Drugs 13 (4):2105–23. doi: 10.3390/md13042105.
   PubMed Web of Science ®Google Scholar
• Gupta, R., C. Kim, N. Agarwal, B. Lieber, and E. A. Monaco, 3rd. 2015. Understanding the influence of Parkinson disease on Adolf Hitler’s decision-making during World War II. World Neurosurgery 84 (5):1447–52. doi: 10.1016/j.wneu.2015.06.014.
   PubMed Web of Science ®Google Scholar
• Gürsoy, K., H. Teymur, G. Koca, Ö. Tanas Işikçi, F. B. Göktaş Demircan, Y. Kankaya, and U. Koçer. 2020. The effect of astaxanthin on random pattern skin flaps. Annals of Plastic Surgery 84 (2):208–15. doi: 10.1097/SAP.0000000000002013.
   PubMed Web of Science ®Google Scholar
• Guzik, A., and C. Bushnell. 2017. Stroke epidemiology and risk factor management. Continuum 23 (1, Cerebrovascular Disease):15–39. doi: 10.1212/con.0000000000000416.
   PubMedGoogle Scholar
• Haider, L., T. Zrzavy, S. Hametner, R. Höftberger, F. Bagnato, G. Grabner, S. Trattnig, S. Pfeifenbring, W. Brück, and H. Lassmann. 2016. The topograpy of demyelination and neurodegeneration in the multiple sclerosis brain. Brain 139 (Pt 3):807–15. doi: 10.1093/brain/awv398.
   PubMedGoogle Scholar
• Hama, S., K. Takahashi, Y. Inai, K. Shiota, R. Sakamoto, A. Yamada, H. Tsuchiya, K. Kanamura, E. Yamashita, and K. Kogure. 2012. Protective effects of topical application of a poorly soluble antioxidant astaxanthin liposomal formulation on ultraviolet-induced skin damage. Journal of Pharmaceutical Sciences 101 (8):2909–16. doi: 10.1002/jps.23216.
   PubMed Web of Science ®Google Scholar
• Han, H., J. W. Lim, and H. Kim. 2020. Astaxanthin inhibits Helicobacter pylori-induced inflammatory and oncogenic responses in gastric mucosal tissues of mice. Journal of Cancer Prevention 25 (4):244–51. doi: 10.15430/jcp.2020.25.4.244.
   PubMed Web of Science ®Google Scholar
• Han, J. H., J. H. Ju, Y. S. Lee, J. H. Park, I. J. Yeo, M. H. Park, Y. S. Roh, S. B. Han, and J. T. Hong. 2018. Astaxanthin alleviated ethanol-induced liver injury by inhibition of oxidative stress and inflammatory responses via blocking of STAT3 activity. Scientific Reports 8 (1):14090. doi: 10.1038/s41598-018-32497-w.
   PubMedGoogle Scholar
• Han, L., J. H. Song, J. H. Yoon, Y. G. Park, S. W. Lee, Y. J. Choi, S. W. Nam, J. Y. Lee, and W. S. Park. 2012. TNF-α and TNF-β polymorphisms are associated with susceptibility to osteoarthritis in a Korean population. Korean Journal of Pathology 46 (1):30–7. doi: 10.4132/KoreanJPathol.2012.46.1.30.
   PubMedGoogle Scholar
• Harada, T., K. Watanabe, K. Nabeshima, M. Hamasaki, and H. Iwasaki. 2013. Prognostic significance of fibroblastic foci in usual interstitial pneumonia and non-specific interstitial pneumonia. Respirology 18 (2):278–83. doi: 10.1111/j.1440-1843.2012.02272.x.
   PubMed Web of Science ®Google Scholar
• Hashimoto, H., K. Arai, S. Hayashi, H. Okamoto, J. Takahashi, and M. Chikuda. 2016. The effect of astaxanthin on vascular endothelial growth factor (VEGF) levels and peroxidation reactions in the aqueous humor. Journal of Clinical Biochemistry and Nutrition 59 (1):10–5. doi: 10.3164/jcbn.15-137.
   PubMed Web of Science ®Google Scholar
• Hashimoto, H., K. Arai, S. Hayashi, H. Okamoto, J. Takahashi, M. Chikuda, and Y. Obara. 2013. Effects of astaxanthin on antioxidation in human aqueous humor. Journal of Clinical Biochemistry and Nutrition 53 (1):1–7. doi: 10.3164/jcbn.13-6.
   PubMed Web of Science ®Google Scholar
• Hashimoto, H., K. Arai, J. Takahashi, and M. Chikuda. 2019. Effects of astaxanthin on VEGF level and antioxidation in human aqueous humor: Difference by sex. Journal of Clinical Biochemistry and Nutrition 65 (1):47–51. doi: 10.3164/jcbn.18-110.
   PubMed Web of Science ®Google Scholar
• Hatabu, T., T. Harada, Y. Takao, D. H. Thi, A. Yamasato, T. Horiuchi, A. Mochizuki, and Y. Kondo. 2020. Daily meal supplemented with astaxanthin-enriched yolk has mitigative effects against hypertension in spontaneously hypertensive rats. Biological & Pharmaceutical Bulletin 43 (3):404–8. doi: 10.1248/bpb.b19-01013.
   PubMed Web of Science ®Google Scholar
• Haung, H. Y., Y. C. Wang, Y. C. Cheng, W. Kang, S. H. Hu, D. Liu, C. Xiao, and H. D. Wang. 2020. A novel oral astaxanthin nanoemulsion from Haematococcus pluvialis induces apoptosis in lung metastatic melanoma. Oxidative Medicine and Cellular Longevity 2020:2647670. doi: 10.1155/2020/2647670.
   PubMed Web of Science ®Google Scholar
• Hinz, B., S. H. Phan, V. J. Thannickal, M. Prunotto, A. Desmoulière, J. Varga, O. De Wever, M. Mareel, and G. Gabbiani. 2012. Recent developments in myofibroblast biology: Paradigms for connective tissue remodeling. The American Journal of Pathology 180 (4):1340–55. doi: 10.1016/j.ajpath.2012.02.004.
   PubMed Web of Science ®Google Scholar
• Hix, L. M., S. F. Lockwood, and J. S. Bertram. 2004. Upregulation of connexin 43 protein expression and increased gap junctional communication by water soluble disodium disuccinate astaxanthin derivatives. Cancer Letters 211 (1):25–37. doi: 10.1016/j.canlet.2004.01.036.
   PubMed Web of Science ®Google Scholar
• Hongo, N., Y. Takamura, H. Nishimaru, J. Matsumoto, K. Tobe, T. Saito, T. C. Saido, and H. Nishijo. 2020. Astaxanthin ameliorated parvalbumin-positive neuron deficits and Alzheimer’s disease-related pathological progression in the hippocampus of App(NL-G-F/NL-G-F) mice. Frontiers in Pharmacology 11:307. [ Mismatch] doi: 10.3389/fphar.2020.00307.
   PubMed Web of Science ®Google Scholar
• Hormozi, M., S. Ghoreishi, and P. Baharvand. 2019. Astaxanthin induces apoptosis and increases activity of antioxidant enzymes in LS-180 cells. Artificial Cells, Nanomedicine, and Biotechnology 47 (1):891–5. doi: 10.1080/21691401.2019.1580286.
   PubMed Web of Science ®Google Scholar
• Hoshi, H., W. Hao, Y. Fujita, A. Funayama, Y. Miyauchi, K. Hashimoto, K. Miyamoto, R. Iwasaki, Y. Sato, T. Kobayashi, et al. 2012. Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis. Journal of Bone and Mineral Research 27 (9):2015–23. doi: 10.1002/jbmr.1634.
   PubMed Web of Science ®Google Scholar
• Hoshi, H., F. Monoe, I. Ohsawa, S. Ohta, and T. Miyamoto. 2020. Astaxanthin improves osteopenia caused by aldehyde-stress resulting from Aldh2 mutation due to impaired osteoblastogenesis. Biochemical and Biophysical Research Communications 527 (1):270–5. doi: 10.1016/j.bbrc.2020.04.013.
   PubMed Web of Science ®Google Scholar
• Hossain, A. K. M. M., M. A. Brennan, S. L. Mason, X. Guo, X. A. Zeng, and C. S. Brennan. 2017. The effect of astaxanthin-rich microalgae “Haematococcus pluvialis” and wholemeal flours incorporation in improving the physical and functional properties of cookies. Foods 6 (8):57. doi: 10.3390/foods6080057.
   PubMed Web of Science ®Google Scholar
• Hosseindoust, A., S. M. Oh, H. S. Ko, S. M. Jeon, S. H. Ha, A. Jang, J. S. Son, G. Y. Kim, H. K. Kang, and J. S. Kim. 2020. Muscle antioxidant activity and meat quality are altered by supplementation of astaxanthin in broilers exposed to high temperature. Antioxidants 9 (11):1032. doi: 10.3390/antiox9111032.
   Web of Science ®Google Scholar
• Hsieh, M.-T., K.-C. Huang, C.-Y. Hsieh, T.-T. Tsai, L.-C. Chen, and S.-F. Sung. 2021. Validation of ICD-10-CM diagnosis codes for identification of patients with acute hemorrhagic stroke in a National Health Insurance Claims Database. Clinical Epidemiology 13:43–51. doi: 10.2147/CLEP.S288518.
   PubMed Web of Science ®Google Scholar
• Huang, C., C. Wen, M. Yang, A. Li, C. Fan, D. Gan, Q. Li, J. Zhao, L. Zhu, and D. Lu. 2021. Astaxanthin improved the cognitive deficits in APP/PS1 transgenic mice via selective activation of mTOR. Journal of Neuroimmune Pharmacology 16 (3):609–19. doi: 10.1007/s11481-020-09953-4.
   PubMed Web of Science ®Google Scholar
• Huang, L. J., and W. P. Chen. 2015. Astaxanthin ameliorates cartilage damage in experimental osteoarthritis. Modern Rheumatology 25 (5):768–71. doi: 10.3109/14397595.2015.1008724.
   PubMed Web of Science ®Google Scholar
• Hui, C., P. Tadi, and L. Patti. 2021. Ischemic stroke. StatPearls. © 2021. Treasure Island, FL: StatPearls Publishing LLC.
   Google Scholar
• Hussein, G., H. Goto, S. Oda, T. Iguchi, U. Sankawa, K. Matsumoto, and H. Watanabe. 2005a. Antihypertensive potential and mechanism of action of astaxanthin: II. Vascular reactivity and hemorheology in spontaneously hypertensive rats. Biological and Pharmaceutical Bulletin 28 (6):967–71. doi: 10.1248/bpb.28.967.
   PubMed Web of Science ®Google Scholar
• Hussein, G., H. Goto, S. Oda, U. Sankawa, K. Matsumoto, and H. Watanabe. 2006. Antihypertensive potential and mechanism of action of astaxanthin: III. Antioxidant and histopathological effects in spontaneously hypertensive rats. Biological and Pharmaceutical Bulletin 29 (4):684–8. doi: 10.1248/bpb.29.684.
   PubMed Web of Science ®Google Scholar
• Hussein, G., M. Nakamura, Q. Zhao, T. Iguchi, H. Goto, U. Sankawa, and H. Watanabe. 2005b. Antihypertensive and neuroprotective effects of astaxanthin in experimental animals. Biological & Pharmaceutical Bulletin 28 (1):47–52. doi: 10.1248/bpb.28.47.
   PubMed Web of Science ®Google Scholar
• Hwang, Y. H., S. G. Hong, S. K. Mun, S. J. Kim, S. J. Lee, J. J. Kim, K. Y. Kang, and S. T. Yee. 2017. The protective effects of astaxanthin on the OVA-induced asthma mice model. Molecules 22 (11):2019. doi: 10.3390/molecules22112019.
   PubMed Web of Science ®Google Scholar
• Hwang, Y. H., K. J. Kim, S. J. Kim, S. K. Mun, S. G. Hong, Y. J. Son, and S. T. Yee. 2018. Suppression effect of astaxanthin on osteoclast formation in vitro and bone loss in vivo. International Journal of Molecular Sciences 19 (3):912. doi: 10.3390/ijms19030912.
   PubMed Web of Science ®Google Scholar
• Ikarashi, N., R. Kon, C. Nagoya, A. Ishikura, Y. Sugiyama, J. Takahashi, and K. Sugiyama. 2020. Effect of astaxanthin on the expression and activity of aquaporin-3 in skin in an in-vitro study. Life 10 (9):193. doi: 10.3390/life10090193.
   PubMedGoogle Scholar
• Ikeda, Y., S. Tsuji, A. Satoh, M. Ishikura, T. Shirasawa, and T. Shimizu. 2008. Protective effects of astaxanthin on 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells. Journal of Neurochemistry 107 (6):1730–40. doi: 10.1111/j.1471-4159.2008.05743.x.
   PubMed Web of Science ®Google Scholar
• Inoue, Y., M. Shimazawa, R. Nagano, Y. Kuse, K. Takahashi, K. Tsuruma, M. Hayashi, T. Ishibashi, T. Maoka, and H. Hara. 2017. Astaxanthin analogs, adonixanthin and lycopene, activate Nrf2 to prevent light-induced photoreceptor degeneration. Journal of Pharmacological Sciences 134 (3):147–57. doi: 10.1016/j.jphs.2017.05.011.
   PubMed Web of Science ®Google Scholar
• Iskender, H., G. Yenice, E. Dokumacioglu, A. Hayirli, C. Sevim, A. Dokumacioglu, and K. A. Terim Kapakin. 2020. Astaxanthin alleviates renal damage of rats on high fructose diet through modulating NFκB/SIRT1 pathway and mitigating oxidative stress. Archives of Physiology and Biochemistry 126 (1):89–93. doi: 10.1080/13813455.2018.1493609.
   PubMed Web of Science ®Google Scholar
• Islam, M. A., M. A. Al Mamun, M. Faruk, M. T. Ul Islam, M. M. Rahman, M. N. Alam, A. Rahman, H. M. Reza, and M. A. Alam. 2017. Astaxanthin ameliorates hepatic damage and oxidative stress in carbon tetrachloride-administered rats. Pharmacognosy Research 9 (Suppl 1):S84–S91. doi: 10.4103/pr.pr_26_17.
   PubMedGoogle Scholar
• Isonaka, R., H. Hiruma, T. Katakura, and T. Kawakami. 2011. Inhibition of superoxide dismutase selectively suppresses growth of rat spinal motor neurons: Comparison with phosphorylated neurofilament-containing spinal neurons. Brain Research 1425:13–9. doi: 10.1016/j.brainres.2011.09.046.
   PubMed Web of Science ®Google Scholar
• Ispada, J., T. A. Rodrigues, P. H. B. Risolia, R. S. Lima, D. R. Gonçalves, D. Rettori, M. Nichi, W. B. Feitosa, and F. F. Paula-Lopes. 2018. Astaxanthin counteracts the effects of heat shock on the maturation of bovine oocytes. Reproduction, Fertility, and Development 30 (9):1169–79. doi: 10.1071/rd17271.
   PubMed Web of Science ®Google Scholar
• Ito, N., S. Seki, and F. Ueda. 2018. The protective role of astaxanthin for UV-induced skin deterioration in healthy people—A randomized, double-blind, placebo-controlled trial. Nutrients 10 (7):817. doi: 10.3390/nu10070817.
   PubMed Web of Science ®Google Scholar
• Izumi-Nagai, K., N. Nagai, K. Ohgami, S. Satofuka, Y. Ozawa, K. Tsubota, S. Ohno, Y. Oike, and S. Ishida. 2008. Inhibition of choroidal neovascularization with an anti-inflammatory carotenoid astaxanthin. Investigative Ophthalmology & Visual Science 49 (4):1679–85. doi: 10.1167/iovs.07-1426.
   PubMed Web of Science ®Google Scholar
• Jafari, Z., A. Bigham, S. Sadeghi, S. M. Dehdashti, N. Rabiee, A. Abedivash, M. Bagherzadeh, B. Nasseri, H. Karimi-Maleh, E. Sharifi, et al. 2022. Nanotechnology-abetted astaxanthin formulations in multimodel therapeutic and biomedical applications. Journal of Medicinal Chemistry 65 (1):2–36. doi: 10.1021/acs.jmedchem.1c01144.
   PubMed Web of Science ®Google Scholar
• Jang, H. Y., S. J. Ji, Y. H. Kim, H. Y. Lee, J. S. Shin, H. T. Cheong, J. T. Kim, I. C. Park, H. S. Kong, C. K. Park, et al. 2010. Antioxidative effects of astaxanthin against nitric oxide-induced oxidative stress on cell viability and gene expression in bovine oviduct epithelial cell and the developmental competence of bovine IVM/IVF embryos. Reproduction in Domestic Animals 45 (6):967–74. doi: 10.1111/j.1439-0531.2009.01469.x.
   PubMed Web of Science ®Google Scholar
• Jia, B. Y., D. C. Xiang, Q. Y. Shao, B. Zhang, S. N. Liu, Q. H. Hong, G. B. Quan, and G. Q. Wu. 2020. Inhibitory effects of astaxanthin on postovulatory porcine oocyte aging in vitro. Scientific Reports 10 (1):20217. doi: 10.1038/s41598-020-77359-6.
   PubMed Web of Science ®Google Scholar
• Jia, Y., J. Y. Kim, H. J. Jun, S. J. Kim, J. H. Lee, M. H. Hoang, K. Y. Hwang, S. J. Um, H. I. Chang, and S. J. Lee. 2012. The natural carotenoid astaxanthin, a PPAR-α agonist and PPAR-γ antagonist, reduces hepatic lipid accumulation by rewiring the transcriptome in lipid-loaded hepatocytes. Molecular Nutrition & Food Research 56 (6):878–88. doi: 10.1002/mnfr.201100798.
   PubMed Web of Science ®Google Scholar
• Jiang, G.-L., and M.-J. Zhu. 2019. Preparation of astaxanthin-encapsulated complex with zein and oligochitosan and its application in food processing. LWT 106:179–85. doi: 10.1016/j.lwt.2019.02.055.
   Web of Science ®Google Scholar
• Jiang, W., H. Zhao, L. Zhang, B. Wu, and Z. Zha. 2020. Maintenance of mitochondrial function by astaxanthin protects against bisphenol A-induced kidney toxicity in rats. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 121:109629. doi: 10.1016/j.biopha.2019.109629.
   PubMed Web of Science ®Google Scholar
• Kamada, H., S. Akagi, and S. Watanabe. 2017. Astaxanthin increases progesterone production in cultured bovine luteal cells. Journal of Veterinary Medical Science 79 (6):1103–9. doi: 10.1292/jvms.17-0044.
   PubMed Web of Science ®Google Scholar
• Kanazashi, M., Y. Okumura, S. Al-Nassan, S. Murakami, H. Kondo, F. Nagatomo, N. Fujita, A. Ishihara, R. R. Roy, and H. Fujino. 2013. Protective effects of astaxanthin on capillary regression in atrophied soleus muscle of rats. Acta Physiologica 207 (2):405–15. doi: 10.1111/apha.12018.
   PubMed Web of Science ®Google Scholar
• Kanazashi, M., M. Tanaka, R. Nakanishi, N. Maeshige, and H. Fujino. 2019. Effects of astaxanthin supplementation and electrical stimulation on muscle atrophy and decreased oxidative capacity in soleus muscle during hindlimb unloading in rats. The Journal of Physiological Sciences 69 (5):757–67. doi: 10.1007/s12576-019-00692-7.
   PubMed Web of Science ®Google Scholar
• Kato, T., T. Kasai, A. Sato, S. Ishiwata, S. Yatsu, H. Matsumoto, J. Shitara, A. Murata, M. Shimizu, S. Suda, et al. 2020. Effects of 3-month astaxanthin supplementation on cardiac function in heart failure patients with left ventricular systolic dysfunction—A pilot study. Nutrients 12 (6)1896. doi: 10.3390/nu1206:.
   PubMed Web of Science ®Google Scholar
• Katsumata, T., T. Ishibashi, and D. Kyle. 2014. A sub-chronic toxicity evaluation of a natural astaxanthin-rich carotenoid extract of Paracoccus carotinifaciens in rats. Toxicology Reports 1:582–8. doi: 10.1016/j.toxrep.2014.08.008.
   PubMedGoogle Scholar
• Kavitha, K., J. Kowshik, T. K. Kishore, A. B. Baba, and S. Nagini. 2013. Astaxanthin inhibits NF-κB and Wnt/β-catenin signaling pathways via inactivation of Erk/MAPK and PI3K/Akt to induce intrinsic apoptosis in a hamster model of oral cancer. Biochimica et Biophysica Acta 1830 (10):4433–44. doi: 10.1016/j.bbagen.2013.05.032.
   PubMed Web of Science ®Google Scholar
• Kawamura, A., W. Aoi, R. Abe, Y. Kobayashi, S. Wada, M. Kuwahata, and A. Higashi. 2020. Combined intake of astaxanthin, β-carotene, and resveratrol elevates protein synthesis during muscle hypertrophy in mice. Nutrition 69:110561. doi: 10.1016/j.nut.2019.110561.
   PubMed Web of Science ®Google Scholar
• Ke, Y., S. Bu, H. Ma, L. Gao, Y. Cai, Y. Zhang, and W. Zhou. 2019. Preventive and therapeutic effects of astaxanthin on depressive-like behaviors in high-fat diet and streptozotocin-treated rats. Frontiers in Pharmacology 10:1621. doi: 10.3389/fphar.2019.01621.
   PubMed Web of Science ®Google Scholar
• Khalid, N., G. Shu, B. J. Holland, I. Kobayashi, M. Nakajima, and C. J. Barrow. 2017. Formulation and characterization of O/W nanoemulsions encapsulating high concentration of astaxanthin. Food Research International 102:364–71. doi: 10.1016/j.foodres.2017.06.019.
   PubMed Web of Science ®Google Scholar
• Khan, S. K., T. Malinski, R. P. Mason, R. Kubant, R. F. Jacob, K. Fujioka, S. J. Denstaedt, T. J. King, H. L. Jackson, A. D. Hieber, et al. 2010. Novel astaxanthin prodrug (CDX-085) attenuates thrombosis in a mouse model. Thrombosis Research 126 (4):299–305. doi: 10.1016/j.thromres.2010.07.003.
   PubMed Web of Science ®Google Scholar
• Khanduja, K. L., G. Kaushik, S. Khanduja, C. M. Pathak, J. Laldinpuii, and D. Behera. 2011. Corticosteroids affect nitric oxide generation, total free radicals production, and nitric oxide synthase activity in monocytes of asthmatic patients. Molecular and Cellular Biochemistry 346 (1-2):31–7. doi: 10.1007/s11010-010-0588-1.
   PubMed Web of Science ®Google Scholar
• Kiani, C., L. Chen, Y. J. Wu, A. J. Yee, and B. B. Yang. 2002. Structure and function of aggrecan. Cell Research 12 (1):19–32. doi: 10.1038/sj.cr.7290106.
   PubMed Web of Science ®Google Scholar
• Kiko, T., K. Nakagawa, A. Satoh, T. Tsuduki, K. Furukawa, H. Arai, and T. Miyazawa. 2012. Amyloid β levels in human red blood cells. PLoS One 7 (11):e49620. doi: 10.1371/journal.pone.0049620.
   PubMed Web of Science ®Google Scholar
• Kim, H., Y. T. Ahn, G. S. Lee, S. I. Cho, J. M. Kim, C. Lee, B. K. Lim, S. A. Ju, and W. G. An. 2015. Effects of astaxanthin on dinitrofluorobenzene-induced contact dermatitis in mice. Molecular Medicine Reports 12 (3):3632–8. doi: 10.3892/mmr.2015.3892.
   PubMed Web of Science ®Google Scholar
• Kim, H. Y., Y. M. Kim, and S. Hong. 2019. Astaxanthin suppresses the metastasis of colon cancer by inhibiting the MYC-mediated downregulation of microRNA-29a-3p and microRNA-200a. Scientific Reports 9 (1):9457. doi: 10.1038/s41598-019-45924-3.
   PubMedGoogle Scholar
• Kim, M. S., Y. T. Ahn, C. W. Lee, H. Kim, and W. G. An. 2020. Astaxanthin modulates apoptotic molecules to induce death of SKBR3 breast cancer cells. Marine Drugs 18 (5):266. doi: 10.3390/md18050266.
   PubMed Web of Science ®Google Scholar
• Kim, S. H., and H. Kim. 2020. Transcriptome analysis of the inhibitory effect of astaxanthin on Helicobacter pylori-induced gastric carcinoma cell motility. Marine Drugs 18 (7):365. doi: 10.3390/md18070365.
   PubMed Web of Science ®Google Scholar
• Kim, S. H., J. W. Lim, and H. Kim. 2018. Astaxanthin inhibits mitochondrial dysfunction and interleukin-8 expression in Helicobacter pylori-infected gastric epithelial cells. Nutrients 10 (9):1320. doi: 10.3390/nu10091320.
   PubMed Web of Science ®Google Scholar
• Kim, S. H., J. W. Lim, and H. Kim. 2019. Astaxanthin prevents decreases in superoxide dismutase 2 level and superoxide dismutase activity in Helicobacter pylori-infected gastric epithelial cells. Journal of Cancer Prevention 24 (1):54–8. doi: 10.15430/jcp.2019.24.1.54.
   PubMed Web of Science ®Google Scholar
• Kim, Y. J., Y. A. Kim, and T. Yokozawa. 2009. Protection against oxidative stress, inflammation, and apoptosis of high-glucose-exposed proximal tubular epithelial cells by astaxanthin. Journal of Agricultural and Food Chemistry 57 (19):8793–7. doi: 10.1021/jf9019745.
   PubMed Web of Science ®Google Scholar
• Kistler, A., H. Liechti, L. Pichard, E. Wolz, G. Oesterhelt, A. Hayes, and P. Maurel. 2002. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Archives of Toxicology 75 (11-12):665–75. doi: 10.1007/s00204-001-0287-5.
   PubMed Web of Science ®Google Scholar
• Kitade, H., G. Chen, Y. Ni, and T. Ota. 2017. Nonalcoholic fatty liver disease and insulin resistance: New insights and potential new treatments. Nutrients 9 (4):387. doi: 10.3390/nu9040387.
   PubMed Web of Science ®Google Scholar
• Klingberg, F., B. Hinz, and E. S. White. 2013. The myofibroblast matrix: Implications for tissue repair and fibrosis. The Journal of Pathology 229 (2):298–309. doi: 10.1002/path.4104.
   PubMed Web of Science ®Google Scholar
• Ko, J. C., J. C. Chen, T. J. Wang, H. Y. Zheng, W. C. Chen, P. Y. Chang, and Y. W. Lin. 2016. Astaxanthin down-regulates Rad51 expression via inactivation of AKT kinase to enhance mitomycin C-induced cytotoxicity in human non-small cell lung cancer cells. Biochemical Pharmacology 105:91–100. doi: 10.1016/j.bcp.2016.02.016.
   PubMed Web of Science ®Google Scholar
• Kobori, M., Y. Takahashi, M. Sakurai, Y. Ni, G. Chen, M. Nagashimada, S. Kaneko, and T. Ota. 2017. Hepatic transcriptome profiles of mice with diet-induced nonalcoholic steatohepatitis treated with astaxanthin and vitamin E. International Journal of Molecular Sciences 18 (3):593. doi: 10.3390/ijms18030593.
   PubMed Web of Science ®Google Scholar
• Koehler, U., O. Hildebrandt, M. Dittrich, N. Koehler, and A. Weissflog. 2019. [The pathogenesis of pulmonary emphysema—Laennec was right!]. Pneumologie 73 (2):81–6. doi: 10.1055/a-0730-0216.[Mismatch
   PubMed Web of Science ®Google Scholar
• Kohandel, Z., T. Farkhondeh, M. Aschner, and S. Samarghandian. 2021. Nrf2 a molecular therapeutic target for astaxanthin. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 137:111374. doi: 10.1016/j.biopha.2021.111374.
   PubMed Web of Science ®Google Scholar
• Kovalevich, J., and D. Langford. 2013. Considerations for the use of SH-SY5Y neuroblastoma cells in neurobiology. Methods in Molecular Biology 1078:9–21. doi: 10.1007/978-1-62703-640-5_2.
   PubMedGoogle Scholar
• Kowshik, J., A. B. Baba, H. Giri, G. Deepak Reddy, M. Dixit, and S. Nagini. 2014. Astaxanthin inhibits JAK/STAT-3 signaling to abrogate cell proliferation, invasion and angiogenesis in a hamster model of oral cancer. PLoS One 9 (10):e109114. doi: 10.1371/journal.pone.0109114.
   PubMed Web of Science ®Google Scholar
• Krestinin, R., Y. Baburina, I. Odinokova, A. Kruglov, I. Fadeeva, A. Zvyagina, L. Sotnikova, and O. Krestinina. 2020. Isoproterenol-induced permeability transition pore-related dysfunction of heart mitochondria is attenuated by astaxanthin. Biomedicines 8 (10):437. doi: 10.3390/biomedicines8100437.
   PubMed Web of Science ®Google Scholar
• Krestinina, O., Y. Baburina, R. Krestinin, I. Odinokova, I. Fadeeva, and L. Sotnikova. 2020. Astaxanthin prevents mitochondrial impairment induced by isoproterenol in isolated rat heart mitochondria. Antioxidants 9 (3):262. doi: 10.3390/antiox9030262.
   Web of Science ®Google Scholar
• Kubo, H., K. Asai, K. Kojima, A. Sugitani, Y. Kyomoto, A. Okamoto, K. Yamada, N. Ijiri, T. Watanabe, K. Hirata, et al. 2019. Astaxanthin suppresses cigarette smoke-induced emphysema through Nrf2 activation in mice. Marine Drugs 17 (12):673. doi: 10.3390/md17120673.
   PubMed Web of Science ®Google Scholar
• Küçüködük, A., F. Helvacioglu, N. Haberal, A. Dagdeviren, D. Bacanli, G. Yilmaz, and I. Akkoyun. 2019. Antiproliferative and anti-apoptotic effect of astaxanthin in an oxygen-induced retinopathy mouse model. Canadian Journal of Ophthalmology. Journal Canadien d’Ophtalmologie 54 (1):65–74. doi: 10.1016/j.jcjo.2018.02.017.
   PubMed Web of Science ®Google Scholar
• Kumar, A., N. Dhaliwal, J. Dhaliwal, R. N. Dharavath, and K. Chopra. 2020. Astaxanthin attenuates oxidative stress and inflammatory responses in complete Freund-adjuvant-induced arthritis in rats. Pharmacological Reports 72 (1):104–14. doi: 10.1007/s43440-019-00022-z.
   PubMed Web of Science ®Google Scholar
• Kupcinskas, L., P. Lafolie, A. Lignell, G. Kiudelis, L. Jonaitis, K. Adamonis, L. P. Andersen, and T. Wadström. 2008. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled study. Phytomedicine 15 (6-7):391–9. doi: 10.1016/j.phymed.2008.04.004.
   PubMed Web of Science ®Google Scholar
• Kuraji, M., T. Matsuno, and T. Satoh. 2016. Astaxanthin affects oxidative stress and hyposalivation in aging mice. Journal of Clinical Biochemistry and Nutrition 59 (2):79–85. doi: 10.3164/jcbn.15-150.
   PubMed Web of Science ®Google Scholar
• Kuriakose, D., and Z. Xiao. 2020. Pathophysiology and treatment of stroke: Present status and future perspectives. International Journal of Molecular Sciences 21 (20):7609. doi: 10.3390/ijms21207609.
   PubMed Web of Science ®Google Scholar
• Kuroki, T., S. Ikeda, T. Okada, T. Maoka, A. Kitamura, M. Sugimoto, and S. Kume. 2013. Astaxanthin ameliorates heat stress-induced impairment of blastocyst development in vitro: Astaxanthin colocalization with and action on mitochondria. Journal of Assisted Reproduction and Genetics 30 (5):623–31. doi: 10.1007/s10815-013-9987-z.
   PubMed Web of Science ®Google Scholar
• Lakey-Beitia, J., J. Kumar D, M. L. Hegde, and K. S. Rao. 2019. Carotenoids as novel therapeutic molecules against neurodegenerative disorders: Chemistry and molecular docking analysis. International Journal of Molecular Sciences 20 (22):5553. doi: 10.3390/ijms20225553.
   PubMed Web of Science ®Google Scholar
• Landon, R., V. Gueguen, H. Petite, D. Letourneur, G. Pavon-Djavid, and F. Anagnostou. 2020. Impact of astaxanthin on diabetes pathogenesis and chronic complications. Marine Drugs 18 (7):357. doi: 10.3390/md18070357.
   PubMed Web of Science ®Google Scholar
• Lauver, D. A., S. F. Lockwood, and B. R. Lucchesi. 2005. Disodium disuccinate astaxanthin (Cardax) attenuates complement activation and reduces myocardial injury following ischemia/reperfusion. Journal of Pharmacology and Experimental Therapeutics 314 (2):686–92. doi: 10.1124/jpet.105.087114.
   PubMed Web of Science ®Google Scholar
• Lawler, J. 2002. Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth. Journal of Cellular and Molecular Medicine 6 (1):1–12. doi: 10.1111/j.1582-4934.2002.tb00307.x.
   PubMed Web of Science ®Google Scholar
• Le, Y., X. Zhou, J. Zheng, F. Yu, Y. Tang, Z. Yang, G. Ding, and Y. Chen. 2020. Anti-hyperuricemic effects of astaxanthin by regulating xanthine oxidase, adenosine deaminase and urate transporters in rats. Marine Drugs 18 (12):610. doi: 10.3390/md18120610.
   PubMed Web of Science ®Google Scholar
• Ledda, A., G. Belcaro, M. Dugall, R. Luzzi, M. Hosoi, B. Feragalli, R. Cotellese, V. Cosentino, M. Cosentino, R. Eggenhoffner, et al. 2017. A natural pharma standard supplement formulation to control treatment-related toxicity and oxidative stress in genitourinary cancer: A preliminary study. European Review for Medical and Pharmacological Sciences 21 (18):4196–202.
   PubMed Web of Science ®Google Scholar
• Lee, D. H., C. S. Kim, and Y. J. Lee. 2011. Astaxanthin protects against MPTP/MPP+-induced mitochondrial dysfunction and ROS production in vivo and in vitro. Food and Chemical Toxicology 49 (1):271–80. doi: 10.1016/j.fct.2010.10.029.
   PubMed Web of Science ®Google Scholar
• Lee, D. H., Y. J. Lee, and K. H. Kwon. 2010. Neuroprotective effects of astaxanthin in oxygen-glucose deprivation in SH-SY5Y cells and global cerebral ischemia in rat. Journal of Clinical Biochemistry and Nutrition 47 (2):121–9. doi: 10.3164/jcbn.10-29.
   PubMed Web of Science ®Google Scholar
• Lee, H., J. W. Lim, and H. Kim. 2020. Effect of astaxanthin on activation of autophagy and inhibition of apoptosis in Helicobacter pylori-infected gastric epithelial cell line AGS. Nutrients 12 (6):1750. doi: 10.3390/nu12061750.
   PubMed Web of Science ®Google Scholar
• Lee, Y. S., S. H. Jeon, H. J. Ham, H. P. Lee, M. J. Song, and J. T. Hong. 2020. Improved anti-inflammatory effects of liposomal astaxanthin on a phthalic anhydride-induced atopic dermatitis model. Frontiers in Immunology 11:565285. doi: 10.3389/fimmu.2020.565285.
   PubMed Web of Science ®Google Scholar
• Leppik, I. E. 2018. Status epilepticus in the elderly. Epilepsia 59 (Suppl 2):140–3. doi: 10.1111/epi.14497.
   PubMedGoogle Scholar
• Levene, A. P., and R. D. Goldin. 2012. The epidemiology, pathogenesis and histopathology of fatty liver disease. Histopathology 61 (2):141–52. doi: 10.1111/j.1365-2559.2011.04145.x.
   PubMed Web of Science ®Google Scholar
• Lewerenz, J., and P. Maher. 2015. Chronic glutamate toxicity in neurodegenerative diseases—What is the evidence? Frontiers in Neuroscience 9:469. doi: 10.3389/fnins.2015.00469.
   PubMed Web of Science ®Google Scholar
• Li, F. M., Y. Liu, J. F. Liao, and X. L. Duan. 2018. [The preliminary study on anti-photodamaged effect of astaxanthin liposomes in mice skin]. Sichuan da xue xue bao Yi xue ban = Journal of Sichuan University Medical Science Edition 49 (5):712–5.
   PubMedGoogle Scholar
• Li, H., J. Li, C. Hou, J. Li, H. Peng, and Q. Wang. 2020. The effect of astaxanthin on inflammation in hyperosmolarity of experimental dry eye model in vitro and in vivo. Experimental Eye Research 197:108113. doi: 10.1016/j.exer.2020.108113.
   PubMed Web of Science ®Google Scholar
• Li, J., F. Wang, Y. Xia, W. Dai, K. Chen, S. Li, T. Liu, Y. Zheng, J. Wang, W. Lu, et al. 2015. Astaxanthin pretreatment attenuates hepatic ischemia reperfusion-induced apoptosis and autophagy via the ROS/MAPK pathway in mice. Marine Drugs 13 (6):3368–87. doi: 10.3390/md13063368.
   PubMed Web of Science ®Google Scholar
• Li, L., Y. Chen, D. Jiao, S. Yang, L. Li, and P. Li. 2020. Protective effect of astaxanthin on ochratoxin A-induced kidney injury to mice by regulating oxidative stress-related NRF2/KEAP1 pathway. Molecules 25 (6):1386. doi: 10.3390/molecules25061386.
   PubMed Web of Science ®Google Scholar
• Li, R., H. Wu, W. W. Zhuo, Q. F. Mao, H. Lan, Y. Zhang, and S. Hua. 2015. Astaxanthin normalizes epigenetic modifications of bovine somatic cell cloned embryos and decreases the generation of lipid peroxidation. Reproduction in Domestic Animals = Zuchthygiene 50 (5):793–9. doi: 10.1111/rda.12589.
   PubMed Web of Science ®Google Scholar
• Li, W., A. Hellsten, L. S. Jacobsson, H. M. Blomqvist, A. G. Olsson, and X. M. Yuan. 2004. Alpha-tocopherol and astaxanthin decrease macrophage infiltration, apoptosis and vulnerability in atheroma of hyperlipidaemic rabbits. Journal of Molecular and Cellular Cardiology 37 (5):969–78. doi: 10.1016/j.yjmcc.2004.07.009.
   PubMed Web of Science ®Google Scholar
• Li, X., T. Matsumoto, M. Takuwa, M. Saeed Ebrahim Shaiku Ali, T. Hirabashi, H. Kondo, and H. Fujino. 2020. Protective effects of astaxanthin supplementation against ultraviolet-induced photoaging in hairless mice. Biomedicines 8 (2):18. doi: 10.3390/biomedicines8020018.
   PubMed Web of Science ®Google Scholar
• Li, X., Z. Qi, L. Zhao, and Z. Yu. 2016. Astaxanthin reduces type 2 diabetic‑associated cognitive decline in rats via activation of PI3K/Akt and attenuation of oxidative stress. Molecular Medicine Reports 13 (1):973–9. doi: 10.3892/mmr.2015.4615.
   PubMed Web of Science ®Google Scholar
• Li, Z., X. Dong, H. Liu, X. Chen, H. Shi, Y. Fan, D. Hou, and X. Zhang. 2013. Astaxanthin protects ARPE-19 cells from oxidative stress via upregulation of Nrf2-regulated phase II enzymes through activation of PI3K/Akt. Molecular Vision 19:1656–66.
   PubMed Web of Science ®Google Scholar
• Li, Z., Y. Wang, and B. Mo. 2002. [The effects of carotenoids on the proliferation of human breast cancer cell and gene expression of bcl-2]. Zhonghua yu fang yi xue za zhi [Chinese Journal of Preventive Medicine] 36 (4):254–7.
   PubMedGoogle Scholar
• Liao, K. S., C. L. Wei, J. C. Chen, H. Y. Zheng, W. C. Chen, C. H. Wu, T. J. Wang, Y. S. Peng, P. Y. Chang, and Y. W. Lin. 2016. Astaxanthin enhances pemetrexed-induced cytotoxicity by downregulation of thymidylate synthase expression in human lung cancer cells. Regulatory Toxicology and Pharmacology 81:353–61. doi: 10.1016/j.yrtph.2016.09.031.
   PubMed Web of Science ®Google Scholar
• Lim, K. C., F. M. Yusoff, M. Shariff, M. S. Kamarudin, and N. Nagao. 2019. Dietary supplementation of astaxanthin enhances hemato-biochemistry and innate immunity of Asian seabass, Lates calcarifer (Bloch, 1790). Aquaculture 512:734339. doi: 10.1016/j.aquaculture.2019.734339.
   Web of Science ®Google Scholar
• Lin, C. W., C. M. Yang, and C. H. Yang. 2020. Protective effect of astaxanthin on blue light light-emitting diode-induced retinal cell damage via free radical scavenging and activation of PI3K/Akt/Nrf2 pathway in 661W cell model. Marine Drugs 18 (8):387. doi: 10.3390/md18080387.
   PubMed Web of Science ®Google Scholar
• Lin, L., and X. Wang. 2016. Ischemia-reperfusion injury in the brain: Mechanisms and potential therapeutic strategies. Biochemistry & Pharmacology: Open Access 5 (4):213. doi: 10.4172/2167-0501.1000213.
   PubMedGoogle Scholar
• Lin, W. N., K. Kapupara, Y. T. Wen, Y. H. Chen, I. H. Pan, and R. K. Tsai. 2020. Haematococcus pluvialis-derived astaxanthin is a potential neuroprotective agent against optic nerve ischemia. Marine Drugs 18 (2):85. doi: 10.3390/md18020085.
   PubMed Web of Science ®Google Scholar
• Liu, F., A. D. Smith, G. Solano-Aguilar, T. T. Y. Wang, Q. Pham, E. Beshah, Q. Tang, J. F. Urban, Jr., C. Xue, and R. W. Li. 2020. Mechanistic insights into the attenuation of intestinal inflammation and modulation of the gut microbiome by krill oil using in vitro and in vivo models. Microbiome 8 (1):83. doi: 10.1186/s40168-020-00843-8.
   PubMed Web of Science ®Google Scholar
• Liu, G., Y. Shi, X. Peng, H. Liu, Y. Peng, and L. He. 2015. Astaxanthin attenuates adriamycin-induced focal segmental glomerulosclerosis. Pharmacology 95 (3-4):193–200. doi: 10.1159/000381314.
   PubMed Web of Science ®Google Scholar
• Liu, H., H. Liu, L. Zhu, Z. Zhang, X. Zheng, J. Liu, and X. Fu. 2019. Comparative transcriptome analyses provide potential insights into the molecular mechanisms of astaxanthin in the protection against alcoholic liver disease in mice. Marine Drugs 17 (3):181. doi: 10.3390/md17030181.
   PubMed Web of Science ®Google Scholar
• Liu, H., M. Liu, X. Fu, Z. Zhang, L. Zhu, X. Zheng, and J. Liu. 2018. Astaxanthin prevents alcoholic fatty liver disease by modulating mouse gut microbiota. Nutrients 10 (9):1298. doi: 10.3390/nu10091298.
   PubMed Web of Science ®Google Scholar
• Liu, J.-K. 2022. Antiaging agents: Safe interventions to slow aging and healthy life span extension. Natural Products and Bioprospecting 12 (1):18. doi: 10.1007/s13659-022-00339-y.
   PubMed Web of Science ®Google Scholar
• Liu, N., J. Chen, D. Gao, W. Li, and D. Zheng. 2018. Astaxanthin attenuates contrast agent-induced acute kidney injury in vitro and in vivo via the regulation of SIRT1/FOXO3a expression. International Urology and Nephrology 50 (6):1171–80. doi: 10.1007/s11255-018-1788-y.
   PubMed Web of Science ®Google Scholar
• Liu, P. H., W. Aoi, M. Takami, H. Terajima, Y. Tanimura, Y. Naito, Y. Itoh, and T. Yoshikawa. 2014. The astaxanthin-induced improvement in lipid metabolism during exercise is mediated by a PGC-1α increase in skeletal muscle. Journal of Clinical Biochemistry and Nutrition 54 (2):86–9. doi: 10.3164/jcbn.13-110.
   PubMed Web of Science ®Google Scholar
• Liu, W., X. F. Kang, G. W. Zhang, H. C. Cai, K. Q. Li, L. L. Wang, and X. J. Shang. 2017. [Protective effect of astaxanthin against epididymal oxidative damagein rats with ornidazole-induced oligoasthenozoospermia]. Zhonghua nan ke xue = National Journal of Andrology 23 (3):206–11.
   PubMedGoogle Scholar
• Liu, X., and T. Osawa. 2007. Cis astaxanthin and especially 9-cis astaxanthin exhibits a higher antioxidant activity in vitro compared to the all-trans isomer. Biochemical and Biophysical Research Communications 357 (1):187–93. doi: 10.1016/j.bbrc.2007.03.120.
   PubMed Web of Science ®Google Scholar
• Liu, X., and T. Osawa. 2009. Astaxanthin protects neuronal cells against oxidative damage and is a potent candidate for brain food. Forum of Nutrition 61:129–35. doi: 10.1159/000212745.
   PubMedGoogle Scholar
• Liu, X., T. Shibata, S. Hisaka, and T. Osawa. 2009. Astaxanthin inhibits reactive oxygen species-mediated cellular toxicity in dopaminergic SH-SY5Y cells via mitochondria-targeted protective mechanism. Brain Research 1254:18–27. doi: 10.1016/j.brainres.2008.11.076.
   PubMed Web of Science ®Google Scholar
• Liu, X., M. Song, Z. Gao, X. Cai, W. Dixon, X. Chen, Y. Cao, and H. Xiao. 2016. Stereoisomers of astaxanthin inhibit human colon cancer cell growth by inducing G2/M cell cycle arrest and apoptosis. Journal of Agricultural and Food Chemistry 64 (41):7750–9. doi: 10.1021/acs.jafc.6b03636.
   PubMed Web of Science ®Google Scholar
• Liu, Y., W. Weng, R. Gao, and Y. Liu. 2019. New insights for cellular and molecular mechanisms of aging and aging-related diseases: Herbal medicine as potential therapeutic approach. Oxidative Medicine and Cellular Longevity 2019:4598167. doi: 10.1155/2019/4598167.
   PubMed Web of Science ®Google Scholar
• Loftis, J. M., and A. Janowsky. 2003. The N-methyl-D-aspartate receptor subunit NR2B: Localization, functional properties, regulation, and clinical implications. Pharmacology & Therapeutics 97 (1):55–85. doi: 10.1016/S0163-7258(02)00302-9.
   PubMed Web of Science ®Google Scholar
• Lotankar, S., K. S. Prabhavalkar, and L. K. Bhatt. 2017. Biomarkers for Parkinson’s disease: Recent advancement. Neuroscience Bulletin 33 (5):585–97. doi: 10.1007/s12264-017-0183-5.
   PubMed Web of Science ®Google Scholar
• Lotfi, A., M. Soleimani, and N. Ghasemi. 2021. Astaxanthin reduces demyelination and oligodendrocytes death in a rat model of multiple sclerosis. Cell Journal 22 (4):565–71. doi: 10.22074/cellj.2021.6999.
   PubMed Web of Science ®Google Scholar
• Lu, Y. P., S. Y. Liu, H. Sun, X. M. Wu, J. J. Li, and L. Zhu. 2010. Neuroprotective effect of astaxanthin on H(2)O(2)-induced neurotoxicity in vitro and on focal cerebral ischemia in vivo. Brain Research 1360:40–8. doi: 10.1016/j.brainres.2010.09.016.
   PubMed Web of Science ®Google Scholar
• Ma, H., S. Chen, H. Xiong, M. Wang, W. Hang, X. Zhu, Y. Zheng, B. Ge, R. Li, and H. Cui. 2020. Astaxanthin from Haematococcus pluvialis ameliorates the chemotherapeutic drug (doxorubicin) induced liver injury through the Keap1/Nrf2/HO-1 pathway in mice. Food & Function 11 (5):4659–71. doi: 10.1039/c9fo02429h.
   PubMed Web of Science ®Google Scholar
• Ma, J., H. M. Chen, X. J. Yan, F. Wang, and W. F. Xu. 2011. [Astaxanthin inhibits sodium azide-induced cytotoxicity in hepatocyte L-02 cells probably by H + transferring function]. Yao xue xue bao = Acta Pharmaceutica Sinica 46 (5):521–6.
   PubMedGoogle Scholar
• Ma, S. Y., M. Röytt, Y. Collan, and J. O. Rinne. 1999. Unbiased morphometrical measurements show loss of pigmented nigral neurones with ageing. Neuropathology and Applied Neurobiology 25 (5):394–9. doi: 10.1046/j.1365-2990.1999.00202.x.
   PubMed Web of Science ®Google Scholar
• Maezawa, T., M. Tanaka, M. Kanazashi, N. Maeshige, H. Kondo, A. Ishihara, and H. Fujino. 2017. Astaxanthin supplementation attenuates immobilization-induced skeletal muscle fibrosis via suppression of oxidative stress. The Journal of Physiological Sciences 67 (5):603–11. doi: 10.1007/s12576-016-0492-x.
   PubMed Web of Science ®Google Scholar
• Manabe, E., O. Handa, Y. Naito, K. Mizushima, S. Akagiri, S. Adachi, T. Takagi, S. Kokura, T. Maoka, and T. Yoshikawa. 2008. Astaxanthin protects mesangial cells from hyperglycemia-induced oxidative signaling. Journal of Cellular Biochemistry 103 (6):1925–37. doi: 10.1002/jcb.21583.
   PubMed Web of Science ®Google Scholar
• Martin, C. O., and M. M. Rymer. 2011. Hemorrhagic stroke: Aneurysmal subarachnoid hemorrhage. Missouri Medicine 108 (2):124–7.
   PubMedGoogle Scholar
• Martínez-Álvarez, Ó., M. M. Calvo, and J. Gómez-Estaca. 2020. Recent advances in astaxanthin micro/nanoencapsulation to improve its stability and functionality as a food ingredient. Marine Drugs 18 (8):406. doi: 10.3390/md18080406.
   PubMed Web of Science ®Google Scholar
• Martínez-Klimova, E., O. E. Aparicio-Trejo, E. Tapia, and J. Pedraza-Chaverri. 2019. Unilateral ureteral obstruction as a model to investigate fibrosis-attenuating treatments. Biomolecules 9 (4):141. doi: 10.3390/biom9040141.
   PubMed Web of Science ®Google Scholar
• Marušić, M., M. Paić, M. Knobloch, and A.-M L. Pršo. 2021. NAFLD, insulin resistance, and diabetes mellitus type 2. Canadian Journal of Gastroenterology & Hepatology 2021:6613827. doi: 10.1155/2021/6613827.
   PubMed Web of Science ®Google Scholar
• Mason, R. P., M. F. Walter, H. P. McNulty, S. F. Lockwood, J. Byun, C. A. Day, and R. F. Jacob. 2006. Rofecoxib increases susceptibility of human LDL and membrane lipids to oxidative damage: A mechanism of cardiotoxicity. Journal of Cardiovascular Pharmacology 47 (Suppl 1):S7–S14. doi: 10.1097/00005344-200605001-00003.
   PubMedGoogle Scholar
• Matsumoto, T., M. Tanaka, T. Ikeji, N. Maeshige, Y. Sakai, T. Akisue, H. Kondo, A. Ishihara, and H. Fujino. 2019. Application of transcutaneous carbon dioxide improves capillary regression of skeletal muscle in hyperglycemia. The Journal of Physiological Sciences 69 (2):317–26. doi: 10.1007/s12576-018-0648-y.
   PubMed Web of Science ®Google Scholar
• Mattson, M. P. 2003. Excitotoxic and excitoprotective mechanisms: Abundant targets for the prevention and treatment of neurodegenerative disorders. Neuromolecular Medicine 3 (2):65–94. doi: 10.1385/NMM:3:2:65.
   PubMed Web of Science ®Google Scholar
• McCarty, M. F. 2011. Full-spectrum antioxidant therapy featuring astaxanthin coupled with lipoprivic strategies and salsalate for management of non-alcoholic fatty liver disease. Medical Hypotheses 77 (4):550–6. doi: 10.1016/j.mehy.2011.06.029.
   PubMed Web of Science ®Google Scholar
• McCarty, M. F., and A. Lerner. 2020. Nutraceuticals targeting generation and oxidant activity of peroxynitrite may aid prevention and control of Parkinson’s disease. International Journal of Molecular Sciences 21 (10):3624. doi: 10.3390/ijms21103624.
   PubMed Web of Science ®Google Scholar
• McMechan, S. R., and A. A. Adgey. 1998. Age related outcome in acute myocardial infarction. Elderly people benefit from thrombolysis and should be included in trials. BMJ 317 (7169):1334–5. doi: 10.1136/bmj.317.7169.1334.
   PubMedGoogle Scholar
• Meephansan, J., A. Rungjang, W. Yingmema, R. Deenonpoe, and S. Ponnikorn. 2017. Effect of astaxanthin on cutaneous wound healing. Clinical, Cosmetic and Investigational Dermatology 10:259–65. doi: 10.2147/ccid.s142795.
   PubMed Web of Science ®Google Scholar
• Melincovici, C. S., A. B. Boşca, S. Şuşman, M. Mărginean, C. Mihu, M. Istrate, I. M. Moldovan, A. L. Roman, and C. M. Mihu. 2018. Vascular endothelial growth factor (VEGF)—Key factor in normal and pathological angiogenesis. Romanian Journal of Morphology and Embryology = Revue roumaine de morphologie et embryologie 59 (2):455–67.
   PubMed Web of Science ®Google Scholar
• Metibemu, D. S., O. A. Akinloye, A. J. Akamo, J. O. Okoye, D. A. Ojo, E. Morifi, and I. O. Omotuyi. 2020. Carotenoid isolates of Spondias mombin demonstrate anticancer effects in DMBA-induced breast cancer in Wistar rats through X-linked inhibitor of apoptosis protein (XIAP) antagonism and anti-inflammation. Journal of Food Biochemistry 44 (12):e13523. doi: 10.1111/jfbc.13523.
   PubMed Web of Science ®Google Scholar
• Metibemu, D. S., O. A. Akinloye, A. J. Akamo, J. O. Okoye, D. A. Ojo, E. Morifi, and I. O. Omotuyi. 2021a. VEGFR-2 kinase domain inhibition as a scaffold for anti-angiogenesis: Validation of the anti-angiogenic effects of carotenoids from Spondias mombin in DMBA model of breast carcinoma in Wistar rats. Toxicology Reports 8:489–98. doi: 10.1016/j.toxrep.2021.02.011.
   PubMed Web of Science ®Google Scholar
• Metibemu, D. S., O. A. Akinloye, A. J. Akamo, J. O. Okoye, and I. O. Omotuyi. 2021b. In-silico HMG-CoA reductase-inhibitory and in-vivo anti-lipidaemic/anticancer effects of carotenoids from Spondias mombin. The Journal of Pharmacy and Pharmacology 73 (10):1377–86. doi: 10.1093/jpp/rgab103.
   PubMed Web of Science ®Google Scholar
• Miki, Y., K. Tanji, F. Mori, A. Kakita, H. Takahashi, and K. Wakabayashi. 2017. PLA2G6 accumulates in Lewy bodies in PARK14 and idiopathic Parkinson’s disease. Neuroscience Letters 645:40–5. doi: 10.1016/j.neulet.2017.02.027.
   PubMed Web of Science ®Google Scholar
• Minh Hung, H., M. T. Nguyen, P. T. Tran, V. K. Truong, J. Chapman, L. H. Quynh Anh, P. Derreumaux, V. V. Vu, and S. T. Ngo. 2020. Impact of the astaxanthin, betanin, and EGCG compounds on small oligomers of amyloid Aβ40 peptide. Journal of Chemical Information and Modeling 60 (3):1399–408. doi: 10.1021/acs.jcim.9b01074.
   PubMed Web of Science ®Google Scholar
• Mohammadi Roushandeh, A., I. Salehi, and M. Mortazavi. 2015. Protective effects of restricted diet and antioxidants on testis tissue in rats fed with high-fat diet. Iranian Biomedical Journal 19 (2):96–101. doi: 10.6091/ibj.1398.2015.
   PubMedGoogle Scholar
• Monmeesil, P., W. Fungfuang, P. Tulayakul, and U. Pongchairerk. 2019. The effects of astaxanthin on liver histopathology and expression of superoxide dismutase in rat aflatoxicosis. The Journal of Veterinary Medical Science 81 (8):1162–72. doi: 10.1292/jvms.18-0690.
   PubMed Web of Science ®Google Scholar
• Monroy-Ruiz, J., M. Sevilla, R. Carrón, and M. J. Montero. 2011. Astaxanthin-enriched-diet reduces blood pressure and improves cardiovascular parameters in spontaneously hypertensive rats. Pharmacological Research 63 (1):44–50. doi: 10.1016/j.phrs.2010.09.003.
   PubMed Web of Science ®Google Scholar
• Moretti, V. M., T. Mentasti, F. Bellagamba, U. Luzzana, F. Caprino, G. M. Turchini, I. Giani, and F. Valfrè. 2006. Determination of astaxanthin stereoisomers and colour attributes in flesh of rainbow trout (Oncorhynchus mykiss) as a tool to distinguish the dietary pigmentation source. Food Additives and Contaminants 23 (11):1056–63. doi: 10.1080/02652030600838399.
   PubMed Web of Science ®Google Scholar
• Mortazavi, M., I. Salehi, Z. Alizadeh, M. Vahabian, and A. M. Roushandeh. 2014. Protective effects of antioxidants on sperm parameters and seminiferous tubules epithelium in high fat-fed rats. Journal of Reproduction & Infertility 15 (1):22–8.
   PubMedGoogle Scholar
• Mosaad, Y. O., N. A. Gobba, and M. A. Hussein. 2016. Astaxanthin; a promising protector against gentamicin-induced nephrotoxicity in rats. Current Pharmaceutical Biotechnology 17 (13):1189–97. doi: 10.2174/1389201017666160922110740.
   PubMed Web of Science ®Google Scholar
• Murata, K., A. Oyagi, D. Takahira, K. Tsuruma, M. Shimazawa, T. Ishibashi, and H. Hara. 2012. Protective effects of astaxanthin from Paracoccus carotinifaciens on murine gastric ulcer models. Phytotherapy Research 26 (8):1126–32. doi: 10.1002/ptr.3681.
   PubMed Web of Science ®Google Scholar
• Murillo, A. G., D. M. DiMarco, and M. L. Fernandez. 2016. The potential of non-provitamin A carotenoids for the prevention and treatment of non-alcoholic fatty liver disease. Biology 5 (4):42. doi: 10.3390/biology5040042.
   PubMedGoogle Scholar
• Murphy, M. P., and H. LeVine, 3rd. 2010. Alzheimer’s disease and the amyloid-beta peptide. Journal of Alzheimer’s Disease 19 (1):311–23. doi: 10.3233/JAD-2010-1221.
   PubMed Web of Science ®Google Scholar
• Nagendraprabhu, P., and G. Sudhandiran. 2011. Astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of ERK-2, NFkB and COX-2. Investigational New Drugs 29 (2):207–24. doi: 10.1007/s10637-009-9342-5.
   PubMed Web of Science ®Google Scholar
• Nai, Y., H. Liu, X. Bi, H. Gao, and C. Ren. 2018. Protective effect of astaxanthin on acute cerebral infarction in rats. Human & Experimental Toxicology 37 (9):929–36. doi: 10.1177/0960327117745693.
   PubMed Web of Science ®Google Scholar
• Naito, Y., K. Uchiyama, W. Aoi, G. Hasegawa, N. Nakamura, N. Yoshida, T. Maoka, J. Takahashi, and T. Yoshikawa. 2004. Prevention of diabetic nephropathy by treatment with astaxanthin in diabetic db/db mice. BioFactors 20 (1):49–59. doi: 10.1002/biof.5520200105.
   PubMed Web of Science ®Google Scholar
• Naito, Y., K. Uchiyama, K. Mizushima, M. Kuroda, S. Akagiri, T. Takagi, O. Handa, S. Kokura, N. Yoshida, H. Ichikawa, et al. 2006. Microarray profiling of gene expression patterns in glomerular cells of astaxanthin-treated diabetic mice: A nutrigenomic approach. International Journal of Molecular Medicine 18 (4):685–95. doi: 10.3892/ijmm.18.4.685.
   PubMed Web of Science ®Google Scholar
• Nakagawa, K., T. Kiko, T. Miyazawa, P. Sookwong, T. Tsuduki, A. Satoh, and T. Miyazawa. 2011. Amyloid β-induced erythrocytic damage and its attenuation by carotenoids. FEBS Letters 585 (8):1249–54. doi: 10.1016/j.febslet.2011.03.060.
   PubMed Web of Science ®Google Scholar
• Nakajima, H., K. Fukazawa, Y. Wakabayashi, K. Wakamatsu, K. Senda, and G. Imokawa. 2012. Abrogating effect of a xanthophyll carotenoid astaxanthin on the stem cell factor-induced stimulation of human epidermal pigmentation. Archives of Dermatological Research 304 (10):803–16. doi: 10.1007/s00403-012-1248-y.
   PubMed Web of Science ®Google Scholar
• Nakajima, H., S. Terazawa, T. Niwano, Y. Yamamoto, and G. Imokawa. 2016. The inhibitory effects of anti-oxidants on ultraviolet-induced up-regulation of the wrinkling-inducing enzyme neutral endopeptidase in human fibroblasts. PLoS One 11 (9):e0161580. doi: 10.1371/journal.pone.0161580.
   PubMed Web of Science ®Google Scholar
• Nakao, R., O. L. Nelson, J. S. Park, B. D. Mathison, P. A. Thompson, and B. P. Chew. 2010. Effect of astaxanthin supplementation on inflammation and cardiac function in BALB/c mice. Anticancer Research 30 (7):2721–5.
   PubMed Web of Science ®Google Scholar
• Namekawa, T., S. Ikeda, M. Sugimoto, and S. Kume. 2010. Effects of astaxanthin-containing oil on development and stress-related gene expression of bovine embryos exposed to heat stress. Reproduction in Domestic Animals 45 (6):e387–91. doi: 10.1111/j.1439-0531.2010.01584.x.
   PubMed Web of Science ®Google Scholar
• Nan, B., Z. Zhao, K. Jiang, X. Gu, H. Li, and X. Huang. 2022. Astaxanthine attenuates cisplatin ototoxicity in vitro and protects against cisplatin-induced hearing loss in vivo. Acta Pharmaceutica Sinica. B 12 (1):167–81. doi: 10.1016/j.apsb.2021.07.002.
   PubMed Web of Science ®Google Scholar
• Ni, X., H. Yu, S. Wang, C. Zhang, and S. Shen. 2017. Astaxanthin inhibits PC-3 xenograft prostate tumor growth in nude mice. Marine Drugs 15 (3):66. doi: 10.3390/md15030066.
   PubMed Web of Science ®Google Scholar
• Ni, Y., M. Nagashimada, F. Zhuge, L. Zhan, N. Nagata, A. Tsutsui, Y. Nakanuma, S. Kaneko, and T. Ota. 2015. Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E. Scientific Reports 5:17192. doi: 10.1038/srep17192.
   PubMed Web of Science ®Google Scholar
• Ni, Y., T. Wu, L. Yang, Y. Xu, T. Ota, and Z. Fu. 2018. Protective effects of astaxanthin on a combination of D-galactose and jet lag-induced aging model in mice. Endocrine Journal 65 (5):569–78. doi: 10.1507/endocrj.EJ17-0500.
   PubMed Web of Science ®Google Scholar
• Ni, Y., F. Zhuge, M. Nagashimada, and T. Ota. 2016. Novel action of carotenoids on non-alcoholic fatty liver disease: Macrophage polarization and liver homeostasis. Nutrients 8 (7):391. doi: 10.3390/nu8070391.
   PubMed Web of Science ®Google Scholar
• Niu, T., R. Xuan, L. Jiang, W. Wu, Z. Zhen, Y. Song, L. Hong, K. Zheng, J. Zhang, Q. Xu, et al. 2018. Astaxanthin induces the Nrf2/HO-1 antioxidant pathway in human umbilical vein endothelial cells by generating trace amounts of ROS. Journal of Agricultural and Food Chemistry 66 (6):1551–9. doi: 10.1021/acs.jafc.7b05493.
   PubMed Web of Science ®Google Scholar
• Nonnekes, J., B. Post, J. W. Tetrud, J. W. Langston, and B. R. Bloem. 2018. MPTP-induced parkinsonism: An historical case series. The Lancet. Neurology 17 (4):300–1. doi: 10.1016/S1474-4422(18)30072-3.
   PubMed Web of Science ®Google Scholar
• Oh, S., Y. J. Kim, E. K. Lee, S. W. Park, and H. G. Yu. 2020. Antioxidative effects of ascorbic acid and astaxanthin on ARPE-19 cells in an oxidative stress model. Antioxidants 9 (9):833. doi: 10.3390/antiox9090833.
   Web of Science ®Google Scholar
• Okada, Y., M. Ishikura, and T. Maoka. 2009. Bioavailability of astaxanthin in Haematococcus algal extract: The effects of timing of diet and smoking habits. Bioscience, Biotechnology, and Biochemistry 73 (9):1928–32. doi: 10.1271/bbb.90078.
   PubMed Web of Science ®Google Scholar
• Okazaki, Y., S. Okada, and S. Toyokuni. 2017. Astaxanthin ameliorates ferric nitrilotriacetate-induced renal oxidative injury in rats. Journal of Clinical Biochemistry and Nutrition 61 (1):18–24. doi: 10.3164/jcbn.16-114.
   PubMed Web of Science ®Google Scholar
• Osterlie, M., B. Bjerkeng, and S. Liaaen-Jensen. 2000. Plasma appearance and distribution of astaxanthin E/Z and R/S isomers in plasma lipoproteins of men after single dose administration of astaxanthin. Journal of Nutritional Biochemistry 11 (10):482–90. doi: 10.1016/s0955-2863(00)00104-2.
   PubMed Web of Science ®Google Scholar
• Ostolaza, A., J. Corroza, and T. Ayuso. 2021. Multiple sclerosis and aging: Comorbidity and treatment challenges. Multiple Sclerosis and Related Disorders 50:102815. doi: 10.1016/j.msard.2021.102815.
   PubMed Web of Science ®Google Scholar
• Otsuka, T., M. Shimazawa, T. Nakanishi, Y. Ohno, Y. Inoue, K. Tsuruma, T. Ishibashi, and H. Hara. 2013. Protective effects of a dietary carotenoid, astaxanthin, against light-induced retinal damage. Journal of Pharmacological Sciences 123 (3):209–18. doi: 10.1254/jphs.13066fp.
   PubMed Web of Science ®Google Scholar
• Palozza, P., C. Torelli, A. Boninsegna, R. Simone, A. Catalano, M. C. Mele, and N. Picci. 2009. Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells. Cancer Letters 283 (1):108–17. doi: 10.1016/j.canlet.2009.03.031.
   PubMed Web of Science ®Google Scholar
• Pan, L., Y. Zhou, X. F. Li, Q. J. Wan, and L. H. Yu. 2017. Preventive treatment of astaxanthin provides neuroprotection through suppression of reactive oxygen species and activation of antioxidant defense pathway after stroke in rats. Brain Research Bulletin 130:211–20. doi: 10.1016/j.brainresbull.2017.01.024.
   PubMed Web of Science ®Google Scholar
• Park, C. H., F. H. Xu, S. S. Roh, Y. O. Song, K. Uebaba, J. S. Noh, and T. Yokozawa. 2015. Astaxanthin and Corni Fructus protect against diabetes-induced oxidative stress, inflammation, and advanced glycation end product in livers of streptozotocin-induced diabetic rats. Journal of Medicinal Food 18 (3):337–44. doi: 10.1089/jmf.2014.3174.
   PubMed Web of Science ®Google Scholar
• Park, D. R., R. Ko, S. H. Kwon, B. Min, S. H. Yun, M. H. Kim, J. Minatelli, S. Hill, and S. Y. Lee. 2016. FlexPro MD, a mixture of krill oil, astaxanthin, and hyaluronic acid, suppresses lipopolysaccharide-induced inflammatory cytokine production through inhibition of NF-κB. Journal of Medicinal Food 19 (12):1196–203. doi: 10.1089/jmf.2016.3787.
   PubMed Web of Science ®Google Scholar
• Park, J. H., I. J. Yeo, J. H. Han, J. W. Suh, H. P. Lee, and J. T. Hong. 2018. Anti-inflammatory effect of astaxanthin in phthalic anhydride-induced atopic dermatitis animal model. Experimental Dermatology 27 (4):378–85. doi: 10.1111/exd.13437.
   PubMed Web of Science ®Google Scholar
• Park, J. H., I. J. Yeo, J. S. Jang, K. C. Kim, M. H. Park, H. P. Lee, S. B. Han, and J. T. Hong. 2019. Combination effect of titrated extract of Centella asiatica and astaxanthin in a mouse model of phthalic anhydride-induced atopic dermatitis. Allergy, Asthma & Immunology Research 11 (4):548–59. doi: 10.4168/aair.2019.11.4.548.
   PubMed Web of Science ®Google Scholar
• Park, J. S., J. H. Chyun, Y. K. Kim, L. L. Line, and B. P. Chew. 2010. Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans. Nutrition & Metabolism 7 (1):18. doi: 10.1186/1743-7075-7-18.
   PubMedGoogle Scholar
• Park, J. S., B. Mathison, M. Hayek, J. Zhang, G. A. Reinhart, and B. Chew. 2012. Astaxanthin modulates age-associated mitochondrial dysfunction in healthy dogs. Journal of Animal Science, 91 (1):268–75. doi: 10.2527/jas.2012-5341.
   PubMed Web of Science ®Google Scholar
• Park, M. H., J. C. Jung, S. Hill, E. Cartwright, M. H. Dohnalek, M. Yu, H. J. Jun, S. B. Han, J. T. Hong, and D. J. Son. 2020. FlexPro MD®, a combination of krill oil, astaxanthin and hyaluronic acid, reduces pain behavior and inhibits inflammatory response in monosodium iodoacetate-induced osteoarthritis in rats. Nutrients 12 (4):956. doi: 10.3390/nu12040956.
   PubMed Web of Science ®Google Scholar
• Patel, A. S., L. Lin, A. Geyer, J. A. Haspel, C. H. An, J. Cao, I. O. Rosas, and D. Morse. 2012. Autophagy in idiopathic pulmonary fibrosis. PLoS One 7 (7):e41394. doi: 10.1371/journal.pone.0041394.
   PubMed Web of Science ®Google Scholar
• Pei, L. P., F. H. Dong, and B. D. Hui. 2008. [Effects of astaxanthin on the damage of osteoblast induced by H2O2]. Zhongguo gu shang = China Journal of Orthopaedics and Traumatology 21 (3):187–9.
   PubMedGoogle Scholar
• Peng, Y. J., J. W. Lu, F. C. Liu, C. H. Lee, H. S. Lee, Y. J. Ho, T. H. Hsieh, C. C. Wu, and C. C. Wang. 2020. Astaxanthin attenuates joint inflammation induced by monosodium urate crystals. FASEB Journal 34 (8):11215–26. doi: 10.1096/fj.202000558RR.
   PubMed Web of Science ®Google Scholar
• Petersen, K. F., and G. I. Shulman. 2006. Etiology of insulin resistance. The American Journal of Medicine 119 (5 Suppl 1):S10–S6. doi: 10.1016/j.amjmed.2006.01.009.
   PubMed Web of Science ®Google Scholar
• Phan, S. H. 2002. The myofibroblast in pulmonary fibrosis. Chest 122 (6 Suppl):286S–9S. doi: 10.1378/chest.122.6_suppl.286s.
   PubMed Web of Science ®Google Scholar
• Phaniendra, A., D. B. Jestadi, and L. Periyasamy. 2015. Free radicals: Properties, sources, targets, and their implication in various diseases. Indian Journal of Clinical Biochemistry 30 (1):11–26. doi: 10.1007/s12291-014-0446-0.
   PubMed Web of Science ®Google Scholar
• Piermarocchi, S., S. Saviano, V. Parisi, M. Tedeschi, G. Panozzo, G. Scarpa, G. Boschi, and G. Lo Giudice. 2012. Carotenoids in Age-related Maculopathy Italian Study (CARMIS): Two-year results of a randomized study. European Journal of Ophthalmology 22 (2):216–25. doi: 10.5301/ejo.5000069.
   PubMed Web of Science ®Google Scholar
• Polotow, T. G., C. V. Vardaris, A. R. Mihaliuc, M. S. Gonçalves, B. Pereira, D. Ganini, and M. P. Barros. 2014. Astaxanthin supplementation delays physical exhaustion and prevents redox imbalances in plasma and soleus muscles of Wistar rats. Nutrients 6 (12):5819–38. doi: 10.3390/nu6125819.
   PubMed Web of Science ®Google Scholar
• Poncyljusz, W., A. Falkowski, I. Kojder, E. Cebula, L. Sagan, J. Czechowski, and A. Walecka. 2007. Treatment of acute ischemic brain infarction with the assistance of local intraarterial thrombolysis with recombinant tissue-type plasminogen activator. Acta Radiologica 48 (7):774–80. doi: 10.1080/02841850701408228.
   PubMed Web of Science ®Google Scholar
• Prabhu, P. N., P. Ashokkumar, and G. Sudhandiran. 2009. Antioxidative and antiproliferative effects of astaxanthin during the initiation stages of 1,2-dimethyl hydrazine-induced experimental colon carcinogenesis. Fundamental & Clinical Pharmacology 23 (2):225–34. doi: 10.1111/j.1472-8206.2009.00669.x.
   PubMed Web of Science ®Google Scholar
• Qiu, X., K. Fu, X. Zhao, Y. Zhang, Y. Yuan, S. Zhang, X. Gu, and H. Guo. 2015. Protective effects of astaxanthin against ischemia/reperfusion induced renal injury in mice. Journal of Translational Medicine 13:28. doi: 10.1186/s12967-015-0388-1.
   PubMed Web of Science ®Google Scholar
• Qu, X., Z. Zhang, W. Hu, M. Lou, B. Zhai, S. Mei, Z. Hu, L. Zhang, D. Liu, Z. Liu, et al. 2020. Attenuation of the Na/K‑ATPase/Src/ROS amplification signaling pathway by astaxanthin ameliorates myocardial cell oxidative stress injury. Molecular Medicine Reports 22 (6):5125–34. doi: 10.3892/mmr.2020.11613.
   PubMed Web of Science ®Google Scholar
• Rahman, S. O., B. P. Panda, S. Parvez, M. Kaundal, S. Hussain, M. Akhtar, and A. K. Najmi. 2019. Neuroprotective role of astaxanthin in hippocampal insulin resistance induced by Aβ peptides in animal model of Alzheimer’s disease. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 110:47–58. doi: 10.1016/j.biopha.2018.11.043.
   PubMed Web of Science ®Google Scholar
• Ritto, D., S. Tanasawet, S. Singkhorn, W. Klaypradit, P. Hutamekalin, V. Tipmanee, and W. Sukketsiri. 2017. Astaxanthin induces migration in human skin keratinocytes via Rac1 activation and RhoA inhibition. Nutrition Research and Practice 11 (4):275–80. doi: 10.4162/nrp.2017.11.4.275.
   PubMed Web of Science ®Google Scholar
• Roy-O’Reilly, M., and L. D. McCullough. 2018. Age and sex are critical factors in ischemic stroke pathology. Endocrinology 159 (8):3120–31. doi: 10.1210/en.2018-00465.
   PubMed Web of Science ®Google Scholar
• Ryu, S. K., T. J. King, K. Fujioka, J. Pattison, F. J. Pashkow, and S. Tsimikas. 2012. Effect of an oral astaxanthin prodrug (CDX-085) on lipoprotein levels and progression of atherosclerosis in LDLR(-/-) and ApoE(-/-) mice. Atherosclerosis 222 (1):99–105. doi: 10.1016/j.atherosclerosis.2012.02.002.
   PubMed Web of Science ®Google Scholar
• Sakai, S., A. Nishida, M. Ohno, O. Inatomi, S. Bamba, M. Sugimoto, M. Kawahara, and A. Andoh. 2019. Astaxanthin, a xanthophyll carotenoid, prevents development of dextran sulphate sodium-induced murine colitis. Journal of Clinical Biochemistry and Nutrition 64 (1):66–72. doi: 10.3164/jcbn.18-47.
   PubMed Web of Science ®Google Scholar
• Samii, A., J. G. Nutt, and B. R. Ransom. 2004. Parkinson’s disease. The Lancet 363 (9423):1783–93. doi: 10.1016/S0140-6736(04)16305-8.
   PubMed Web of Science ®Google Scholar
• Santangelo, K. S., G. J. Nuovo, and A. L. Bertone. 2012. In vivo reduction or blockade of interleukin-1β in primary osteoarthritis influences expression of mediators implicated in pathogenesis. Osteoarthritis and Cartilage 20 (12):1610–8. doi: 10.1016/j.joca.2012.08.011.
   PubMed Web of Science ®Google Scholar
• Sasaki, Y., N. Kobara, S. Higashino, J. C. Giddings, and J. Yamamoto. 2011. Astaxanthin inhibits thrombosis in cerebral vessels of stroke-prone spontaneously hypertensive rats. Nutrition Research 31 (10):784–9. doi: 10.1016/j.nutres.2011.09.010.
   PubMed Web of Science ®Google Scholar
• Sato, M., M. Markiewicz, M. Yamanaka, A. Bielawska, C. Mao, L. M. Obeid, Y. A. Hannun, and M. Trojanowska. 2003. Modulation of Transforming Growth Factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators. The Journal of Biological Chemistry 278 (11):9276–82. doi: 10.1074/jbc.M211529200.
   PubMed Web of Science ®Google Scholar
• Savio, L. E. B., P. de Andrade Mello, C. G. da Silva, and R. Coutinho-Silva. 2018. The P2X7 receptor in inflammatory diseases: Angel or demon? Frontiers in Pharmacology 9 (52):52. doi: 10.3389/fphar.2018.00052.
   PubMedGoogle Scholar
• Seo, J.-K., R. Parvin, J. Park, and H.-S. Yang. 2021. Utilization of astaxanthin as a synthetic antioxidant replacement for emulsified sausages. Antioxidants 10 (3):407. doi: 10.3390/antiox10030407.
   Web of Science ®Google Scholar
• Sharma, K., D. Sharma, M. Sharma, N. Sharma, P. Bidve, N. Prajapati, K. Kalia, and V. Tiwari. 2018. Astaxanthin ameliorates behavioral and biochemical alterations in in-vitro and in-vivo model of neuropathic pain. Neuroscience Letters 674:162–70. doi: 10.1016/j.neulet.2018.03.030.
   PubMed Web of Science ®Google Scholar
• Sharma, P., and A. Arora. 2020. Clinical presentation of alcoholic liver disease and non-alcoholic fatty liver disease: Spectrum and diagnosis. Translational Gastroenterology and Hepatology 5:19. doi: 10.21037/tgh.2019.10.02.
   PubMed Web of Science ®Google Scholar
• Shen, D. F., H. P. Qi, C. Ma, M. X. Chang, W. N. Zhang, and R. R. Song. 2021. Astaxanthin suppresses endoplasmic reticulum stress and protects against neuron damage in Parkinson’s disease by regulating miR-7/SNCA axis. Neuroscience Research 165:51–60. doi: 10.1016/j.neures.2020.04.003.
   PubMed Web of Science ®Google Scholar
• Shen, H., C. C. Kuo, J. Chou, A. Delvolve, S. N. Jackson, J. Post, A. S. Woods, B. J. Hoffer, Y. Wang, and B. K. Harvey. 2009. Astaxanthin reduces ischemic brain injury in adult rats. FASEB Journal 23 (6):1958–68. doi: 10.1096/fj.08-123281.
   PubMed Web of Science ®Google Scholar
• Shen, M., K. Chen, J. Lu, P. Cheng, L. Xu, W. Dai, F. Wang, L. He, Y. Zhang, W. Chengfen, et al. 2014. Protective effect of astaxanthin on liver fibrosis through modulation of TGF-β1 expression and autophagy. Mediators of Inflammation 2014:954502. doi: 10.1155/2014/954502.
   PubMed Web of Science ®Google Scholar
• Shi, Y., P. Lin, X. Wang, G. Zou, and K. Li. 2018. Sphingomyelin phosphodiesterase 1 (SMPD1) mediates the attenuation of myocardial infarction-induced cardiac fibrosis by astaxanthin. Biochemical and Biophysical Research Communications 503 (2):637–43. doi: 10.1016/j.bbrc.2018.06.054.
   PubMed Web of Science ®Google Scholar
• Shibaguchi, T., Y. Yamaguchi, N. Miyaji, T. Yoshihara, H. Naito, K. Goto, D. Ohmori, T. Yoshioka, and T. Sugiura. 2016. Astaxanthin intake attenuates muscle atrophy caused by immobilization in rats. Physiological Reports 4 (15):e12885. doi: 10.14814/phy2.12885.
   PubMedGoogle Scholar
• Shimokawa, T., M. Yoshida, T. Fukuta, T. Tanaka, T. Inagi, and K. Kogure. 2019. Efficacy of high-affinity liposomal astaxanthin on up-regulation of age-related markers induced by oxidative stress in human corneal epithelial cells. Journal of Clinical Biochemistry and Nutrition 64 (1):27–35. doi: 10.3164/jcbn.18-27.
   PubMed Web of Science ®Google Scholar
• Shin, J., J. E. Kim, K. J. Pak, J. I. Kang, T. S. Kim, S. Y. Lee, I. H. Yeo, J. H. Park, J. H. Kim, N. J. Kang, et al. 2017. A combination of soybean and Haematococcus extract alleviates ultraviolet B-induced photoaging. International Journal of Molecular Sciences 18 (3):682. doi: 10.3390/ijms18030682.
   PubMed Web of Science ®Google Scholar
• Showalter, L. A., S. A. Weinman, M. Osterlie, and S. F. Lockwood. 2004. Plasma appearance and tissue accumulation of non-esterified, free astaxanthin in C57BL/6 mice after oral dosing of a disodium disuccinate diester of astaxanthin (Heptax). Comparative Biochemistry and Physiology. Toxicology & Pharmacology 137 (3):227–36. doi: 10.1016/j.cca.2003.12.006.
   PubMed Web of Science ®Google Scholar
• Sila, A., Z. Ghlissi, Z. Kamoun, M. Makni, M. Nasri, A. Bougatef, and Z. Sahnoun. 2015. Astaxanthin from shrimp by-products ameliorates nephropathy in diabetic rats. European Journal of Nutrition 54 (2):301–7. doi: 10.1007/s00394-014-0711-2.
   PubMed Web of Science ®Google Scholar
• Singh, S., N. A. Osna, and K. K. Kharbanda. 2017. Treatment options for alcoholic and non-alcoholic fatty liver disease: A review. World Journal of Gastroenterology 23 (36):6549–70. doi: 10.3748/wjg.v23.i36.6549.
   PubMed Web of Science ®Google Scholar
• Sj, S., B. Veerabhadrappa, S. Subramaniyan, and M. Dyavaiah. 2018. Astaxanthin enhances the longevity of Saccharomyces cerevisiae by decreasing oxidative stress and apoptosis. FEMS Yeast Research 19 (1):1–11. doi: 10.1093/femsyr/foy113.
   Web of Science ®Google Scholar
• Soenen, S., C. K. Rayner, K. L. Jones, and M. Horowitz. 2016. The ageing gastrointestinal tract. Current Opinion in Clinical Nutrition and Metabolic Care 19 (1):12–8. doi: 10.1097/mco.0000000000000238.
   PubMed Web of Science ®Google Scholar
• Song, L. K., K. L. Ma, Y. H. Yuan, Z. Mu, X. Y. Song, F. Niu, N. Han, and N. H. Chen. 2015. Targeted overexpression of α-synuclein by rAAV2/1 vectors induces progressive nigrostriatal degeneration and increases vulnerability to MPTP in mouse. PLoS One 10 (6):e0131281. doi: 10.1371/journal.pone.0131281.
   PubMed Web of Science ®Google Scholar
• Song, X., B. Wang, S. Lin, L. Jing, C. Mao, P. Xu, C. Lv, W. Liu, and J. Zuo. 2014. Astaxanthin inhibits apoptosis in alveolar epithelial cells type II in vivo and in vitro through the ROS-dependent mitochondrial signalling pathway. Journal of Cellular and Molecular Medicine 18 (11):2198–212. doi: 10.1111/jcmm.12347.
   PubMed Web of Science ®Google Scholar
• Song, X., P. Xu, C. Meng, C. Song, T. S. Blackwell, R. Li, H. Li, J. Zhang, and C. Lv. 2019. lncITPF promotes pulmonary fibrosis by targeting hnRNP-L depending on its host gene ITGBL1. Molecular Therapy 27 (2):380–93. doi: 10.1016/j.ymthe.2018.08.026.
   PubMed Web of Science ®Google Scholar
• Sowmya, P. R., B. P. Arathi, K. Vijay, V. Baskaran, and R. Lakshminarayana. 2017. Astaxanthin from shrimp efficiently modulates oxidative stress and allied cell death progression in MCF-7 cells treated synergistically with β-carotene and lutein from greens. Food and Chemical Toxicology 106 (Pt A):58–69. doi: 10.1016/j.fct.2017.05.024.
   PubMedGoogle Scholar
• Stewart, J. S., A. Lignell, A. Pettersson, E. Elfving, and M. G. Soni. 2008. Safety assessment of astaxanthin-rich microalgae biomass: Acute and subchronic toxicity studies in rats. Food and Chemical Toxicology 46 (9):3030–6. doi: 10.1016/j.fct.2008.05.038.
   PubMed Web of Science ®Google Scholar
• Sudharshan, S. J., and M. Dyavaiah. 2021. Astaxanthin protects oxidative stress mediated DNA damage and enhances longevity in Saccharomyces cerevisiae. Biogerontology 22 (1):81–100. doi: 10.1007/s10522-020-09904-9.
   PubMed Web of Science ®Google Scholar
• Suganuma, K., H. Nakajima, M. Ohtsuki, and G. Imokawa. 2010. Astaxanthin attenuates the UVA-induced up-regulation of matrix-metalloproteinase-1 and skin fibroblast elastase in human dermal fibroblasts. Journal of Dermatological Science 58 (2):136–42. doi: 10.1016/j.jdermsci.2010.02.009.
   PubMed Web of Science ®Google Scholar
• Sun, K., J. Luo, X. Jing, J. Guo, X. Yao, X. Hao, Y. Ye, S. Liang, J. Lin, G. Wang, et al. 2019. Astaxanthin protects against osteoarthritis via Nrf2: A guardian of cartilage homeostasis. Aging 11 (22):10513–31. doi: 10.18632/aging.102474.
   PubMedGoogle Scholar
• Sun, S. Q., Y. X. Zhao, S. Y. Li, J. W. Qiang, and Y. Z. Ji. 2020. Anti-tumor effects of astaxanthin by inhibition of the expression of STAT3 in prostate cancer. Marine Drugs 18 (8):415. doi: 10.3390/md18080415.
   PubMed Web of Science ®Google Scholar
• Sun, Z., J. Liu, X. Zeng, J. Huangfu, Y. Jiang, M. Wang, and F. Chen. 2011. Protective actions of microalgae against endogenous and exogenous advanced glycation end products (AGEs) in human retinal pigment epithelial cells. Food & Function 2 (5):251–8. doi: 10.1039/c1fo10021a.
   PubMed Web of Science ®Google Scholar
• Suzuki, Y., K. Ohgami, K. Shiratori, X. H. Jin, I. Ilieva, Y. Koyama, K. Yazawa, K. Yoshida, S. Kase, and S. Ohno. 2006. Suppressive effects of astaxanthin against rat endotoxin-induced uveitis by inhibiting the NF-kappaB signaling pathway. Experimental Eye Research 82 (2):275–81. doi: 10.1016/j.exer.2005.06.023.
   PubMed Web of Science ®Google Scholar
• Taan, M., F. Al Ahmad, M. K. Ercksousi, and G. Hamza. 2021. Risk factors associated with multiple sclerosis: A case-control study in Damascus, Syria. Multiple Sclerosis International 2021:8147451. doi: 10.1155/2021/8147451.
   PubMed Web of Science ®Google Scholar
• Tago, Y., T. Fujii, J. Wada, M. Kato, M. Wei, H. Wanibuchi, and M. Kitano. 2014. Genotoxicity and subacute toxicity studies of a new astaxanthin-containing Phaffia rhodozyma extract. The Journal of Toxicological Sciences 39 (3):373–82. doi: 10.2131/jts.39.373.
   PubMed Web of Science ®Google Scholar
• Taksima, T., P. Chonpathompikunlert, M. Sroyraya, P. Hutamekalin, M. Limpawattana, and W. Klaypradit. 2019. Effects of astaxanthin from shrimp shell on oxidative stress and behavior in animal model of Alzheimer’s disease. Marine Drugs 17 (11):628. doi: 10.3390/md17110628.
   PubMed Web of Science ®Google Scholar
• Talukdar, J., B. Bhadra, T. Dattaroy, V. Nagle, and S. Dasgupta. 2020. Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 132:110886. doi: 10.1016/j.biopha.2020.110886.
   PubMed Web of Science ®Google Scholar
• Tan, C., B. Feng, X. Zhang, W. Xia, and S. Xia. 2016. Biopolymer-coated liposomes by electrostatic adsorption of chitosan (chitosomes) as novel delivery systems for carotenoids. Food Hydrocolloids 52:774–84. doi: 10.1016/j.foodhyd.2015.08.016.
   Web of Science ®Google Scholar
• Tanaka, T., T. Kawamori, M. Ohnishi, H. Makita, H. Mori, K. Satoh, and A. Hara. 1995. Suppression of azoxymethane-induced rat colon carcinogenesis by dietary administration of naturally occurring xanthophylls astaxanthin and canthaxanthin during the postinitiation phase. Carcinogenesis 16 (12):2957–63. doi: 10.1093/carcin/16.12.2957.
   PubMed Web of Science ®Google Scholar
• Tanaka, Y., S. Nakayamada, and Y. Okada. 2005. Osteoblasts and osteoclasts in bone remodeling and inflammation. Current Drug Targets. Inflammation and Allergy 4 (3):325–8. doi: 10.2174/1568010054022015.
   PubMedGoogle Scholar
• Terai, K., S. Horie, S. Fukuhara, Y. Miyagawa, K. Kobayashi, and A. Tsujimura. 2020. Combination therapy with antioxidants improves total motile sperm counts: A preliminary study. Reproductive Medicine and Biology 19 (1):89–94. doi: 10.1002/rmb2.12308.
   PubMed Web of Science ®Google Scholar
• Terazawa, S., S. Mori, H. Nakajima, M. Yasuda, and G. Imokawa. 2015. The UVB-stimulated expression of transglutaminase 1 is mediated predominantly via the NFκB signaling pathway: New evidence of its significant attenuation through the specific interruption of the p38/MSK1/NFκBp65 Ser276 axis. PLoS One 10 (8):e0136311. doi: 10.1371/journal.pone.0136311.
   PubMed Web of Science ®Google Scholar
• Terazawa, S., H. Nakajima, M. Shingo, T. Niwano, and G. Imokawa. 2012. Astaxanthin attenuates the UVB-induced secretion of prostaglandin E2 and interleukin-8 in human keratinocytes by interrupting MSK1 phosphorylation in a ROS depletion-independent manner. Experimental Dermatology 21 (Suppl 1):11–7. doi: 10.1111/j.1600-0625.2012.01496.x.
   PubMedGoogle Scholar
• Tiwari, S., V. Atluri, A. Kaushik, A. Yndart, and M. Nair. 2019. Alzheimer’s disease: Pathogenesis, diagnostics, and therapeutics. International Journal of Nanomedicine 14:5541–54. doi: 10.2147/IJN.S200490.
   PubMed Web of Science ®Google Scholar
• Tominaga, K., N. Hongo, M. Karato, and E. Yamashita. 2012. Cosmetic benefits of astaxanthin on humans subjects. Acta Biochimica Polonica 59 (1):43–7. doi: 10.18388/abp.2012_2168.
   PubMed Web of Science ®Google Scholar
• Toyoshima, H., A. Miyata, R. Yoshida, T. Ishige, S. Takaichi, and S. Kawasaki. 2021. Distribution of the water-soluble astaxanthin binding carotenoprotein (AstaP) in Scenedesmaceae. Marine Drugs 19 (6):349. doi: 10.3390/md19060349.
   PubMed Web of Science ®Google Scholar
• Turkez, H., F. Geyikoglu, M. I. Yousef, B. Togar, H. Gürbüz, K. Celik, G. B. Akbaba, and Z. Polat. 2014. Hepatoprotective potential of astaxanthin against 2,3,7,8-tetrachlorodibenzo-p-dioxin in cultured rat hepatocytes. Toxicology and Industrial Health 30 (2):101–12. doi: 10.1177/0748233712452607.
   PubMed Web of Science ®Google Scholar
• Tysnes, O.-B., and A. Storstein. 2017. Epidemiology of Parkinson’s disease. Journal of Neural Transmission 124 (8):901–5. doi: 10.1007/s00702-017-1686-y.
   PubMed Web of Science ®Google Scholar
• Ukibe, K., K. Hashida, N. Yoshida, and H. Takagi. 2009. Metabolic engineering of Saccharomyces cerevisiae for astaxanthin production and oxidative stress tolerance. Applied and Environmental Microbiology 75 (22):7205–11. doi: 10.1128/aem.01249-09.
   PubMed Web of Science ®Google Scholar
• Uyar, A., and T. Yaman. 2020. Evaluation with endothelial nitric oxide synthase (eNOS) immunoreactivity of the protective role of astaxanthin on hepatorenal injury of remote organs caused by ischaemia reperfusion of the lower extremities. Przeglad Gastroenterologiczny 15 (2):161–72. doi: 10.5114/pg.2019.88620.
   PubMed Web of Science ®Google Scholar
• Vaughn, C. B., D. Jakimovski, K. S. Kavak, M. Ramanathan, R. H. B. Benedict, R. Zivadinov, and B. Weinstock-Guttman. 2019. Epidemiology and treatment of multiple sclerosis in elderly populations. Nature Reviews. Neurology 15 (6):329–42. doi: 10.1038/s41582-019-0183-3.
   PubMed Web of Science ®Google Scholar
• Veeruraj, A., L. Liu, J. Zheng, J. Wu, and M. Arumugam. 2019. Evaluation of astaxanthin incorporated collagen film developed from the outer skin waste of squid Doryteuthis singhalensis for wound healing and tissue regenerative applications. Materials Science & Engineering. C, Materials for Biological Applications 95:29–42. doi: 10.1016/j.msec.2018.10.055.
   PubMed Web of Science ®Google Scholar
• Vega, K., J. Edwards, and P. Beilstein. 2015. Subchronic (13-week) toxicity and prenatal developmental toxicity studies of dietary astaxanthin in rats. Regulatory Toxicology and Pharmacology 73 (3):819–28. doi: 10.1016/j.yrtph.2015.10.013.
   PubMed Web of Science ®Google Scholar
• Vijay, K., P. R. Sowmya, B. P. Arathi, S. Shilpa, H. J. Shwetha, M. Raju, V. Baskaran, and R. Lakshminarayana. 2018. Low-dose doxorubicin with carotenoids selectively alters redox status and upregulates oxidative stress-mediated apoptosis in breast cancer cells. Food and Chemical Toxicology 118:675–90. doi: 10.1016/j.fct.2018.06.027.
   PubMed Web of Science ®Google Scholar
• Wan, F. C., C. Zhang, Q. Jin, C. Wei, H. B. Zhao, X. L. Zhang, W. You, X. M. Liu, G. F. Liu, Y. F. Liu, et al. 2020. Protective effects of astaxanthin on lipopolysaccharide-induced inflammation in bovine endometrial epithelial cells†. Biology of Reproduction 102 (2):339–47. doi: 10.1093/biolre/ioz187.
   PubMed Web of Science ®Google Scholar
• Wang, C. C., H. H. Shi, J. Xu, T. Yanagita, C. H. Xue, T. T. Zhang, and Y. M. Wang. 2020. Docosahexaenoic acid-acylated astaxanthin ester exhibits superior performance over non-esterified astaxanthin in preventing behavioral deficits coupled with apoptosis in MPTP-induced mice with Parkinson’s disease. Food & Function 11 (9):8038–50. doi: 10.1039/d0fo01176b.
   PubMed Web of Science ®Google Scholar
• Wang, H. Q., X. B. Sun, Y. X. Xu, H. Zhao, Q. Y. Zhu, and C. Q. Zhu. 2010. Astaxanthin upregulates heme oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells. Brain Research 1360:159–67. doi: 10.1016/j.brainres.2010.08.100.
   PubMed Web of Science ®Google Scholar
• Wang, J. C., and M. Bennett. 2012. Aging and atherosclerosis: Mechanisms, functional consequences, and potential therapeutics for cellular senescence. Circulation Research 111 (2):245–59. doi: 10.1161/circresaha.111.261388.
   PubMed Web of Science ®Google Scholar
• Wang, J. Y., Y. J. Lee, M. C. Chou, R. Chang, C. H. Chiu, Y. J. Liang, and L. S. Wu. 2015. Astaxanthin protects steroidogenesis from hydrogen peroxide-induced oxidative stress in mouse Leydig cells. Marine Drugs 13 (3):1375–88. doi: 10.3390/md13031375.
   PubMed Web of Science ®Google Scholar
• Wang, L., and L. Zhuang. 2019. Astaxanthin ameliorates the lipopolysaccharides-induced subfertility in mouse via Nrf2/HO-1 antioxidant pathway. Dose-Response 17 (3):1559325819878537. doi: 10.1177/1559325819878537.
   Web of Science ®Google Scholar
• Wang, M., X. Deng, Y. Xie, and Y. Chen. 2020. Astaxanthin attenuates neuroinflammation in status epilepticus rats by regulating the ATP-P2X7R signal. Drug Design, Development and Therapy 14:1651–62. doi: 10.2147/dddt.s249162.
   PubMed Web of Science ®Google Scholar
• Wang, M., J. Zhang, X. Song, W. Liu, L. Zhang, X. Wang, and C. Lv. 2013. Astaxanthin ameliorates lung fibrosis in vivo and in vitro by preventing transdifferentiation, inhibiting proliferation, and promoting apoptosis of activated cells. Food and Chemical Toxicology 56:450–8. doi: 10.1016/j.fct.2013.03.004.
   PubMed Web of Science ®Google Scholar
• Wang, R., and P. H. Reddy. 2017. Role of glutamate and NMDA receptors in Alzheimer’s disease. Journal of Alzheimer’s Disease 57 (4):1041–8. doi: 10.3233/JAD-160763.
   PubMed Web of Science ®Google Scholar
• Wang, X., R. Willén, and T. Wadström. 2000. Astaxanthin-rich algal meal and vitamin C inhibit Helicobacter pylori infection in BALB/cA mice. Antimicrobial Agents and Chemotherapy 44 (9):2452–7. doi: 10.1128/aac.44.9.2452-2457.2000.
   PubMed Web of Science ®Google Scholar
• Wang, X. J., D. C. Tian, F. W. Wang, M. H. Zhang, C. D. Fan, W. Chen, M. H. Wang, X. Y. Fu, and J. K. Ma. 2019. Astaxanthin inhibits homocysteine‑induced endothelial cell dysfunction via the regulation of the reactive oxygen species‑dependent VEGF‑VEGFR2‑FAK signaling pathway. Molecular Medicine Reports 19 (6):4753–60. doi: 10.3892/mmr.2019.10162.
   PubMed Web of Science ®Google Scholar
• Wang, Y., Y. Liu, Y. Li, B. Liu, P. Wu, S. Xu, and H. Shi. 2019. Protective effects of astaxanthin on subarachnoid hemorrhage-induced early brain injury: Reduction of cerebral vasospasm and improvement of neuron survival and mitochondrial function. Acta Histochemica 121 (1):56–63. doi: 10.1016/j.acthis.2018.10.014.
   PubMed Web of Science ®Google Scholar
• Wang, Y. L., X. L. Zhu, M. H. Sun, and Y. K. Dang. 2019. Effects of astaxanthin onaxonal regeneration via cAMP/PKA signaling pathway in mice with focal cerebral infarction. European Review for Medical and Pharmacological Sciences 23 (3 Suppl):135–43. doi: 10.26355/eurrev_201908_18640.
   PubMedGoogle Scholar
• Wen, X., A. Huang, J. Hu, Z. Zhong, Y. Liu, Z. Li, X. Pan, and Z. Liu. 2015. Neuroprotective effect of astaxanthin against glutamate-induced cytotoxicity in HT22 cells: Involvement of the Akt/GSK-3β pathway. Neuroscience 303:558–68. doi: 10.1016/j.neuroscience.2015.07.034.
   PubMed Web of Science ®Google Scholar
• Wilcox, G. 2005. Insulin and insulin resistance. The Clinical Biochemist Reviews 26 (2):19–39.
   PubMedGoogle Scholar
• Wolz, E., H. Liechti, B. Notter, G. Oesterhelt, and A. Kistler. 1999. Characterization of metabolites of astaxanthin in primary cultures of rat hepatocytes. Drug Metabolism and Disposition: The Biological Fate of Chemicals 27 (4):456–62.
   PubMed Web of Science ®Google Scholar
• Wu, C., J. Zhang, T. Liu, G. Jiao, C. Li, and B. Hu. 2016. [Astaxanthin inhibits proliferation and promotes apoptosis of A549 lung cancer cells via blocking JAK1/STAT3 pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese Journal of Cellular and Molecular Immunology 32 (6):784–8.
   PubMedGoogle Scholar
• Wu, L., W. Mo, J. Feng, J. Li, Q. Yu, S. Li, J. Zhang, K. Chen, J. Ji, W. Dai, et al. 2020. Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non-alcoholic fatty liver disease by up-regulating the FGF21/PGC-1α pathway. British Journal of Pharmacology 177 (16):3760–77. doi: 10.1111/bph.15099.
   PubMed Web of Science ®Google Scholar
• Wu, Q., X. S. Zhang, H. D. Wang, X. Zhang, Q. Yu, W. Li, M. L. Zhou, and X. L. Wang. 2014. Astaxanthin activates nuclear factor erythroid-related factor 2 and the antioxidant responsive element (Nrf2-ARE) pathway in the brain after subarachnoid hemorrhage in rats and attenuates early brain injury. Marine Drugs 12 (12):6125–41. doi: 10.3390/md12126125.
   PubMed Web of Science ®Google Scholar
• Wu, T. H., J. H. Liao, W. C. Hou, F. Y. Huang, T. J. Maher, and C. C. Hu. 2006. Astaxanthin protects against oxidative stress and calcium-induced porcine lens protein degradation. Journal of Agricultural and Food Chemistry 54 (6):2418–23. doi: 10.1021/jf052651q.
   PubMed Web of Science ®Google Scholar
• Wynn, T. A., and T. R. Ramalingam. 2012. Mechanisms of fibrosis: Therapeutic translation for fibrotic disease. Nature Medicine 18 (7):1028–40. doi: 10.1038/nm.2807.
   PubMed Web of Science ®Google Scholar
• Xie, C., M. Meng, X. Yin, F. He, H. Ye, and D. Xie. 2013. [Effects of astaxanthin on renal fibrosis and cell apoptosis induced by partial unilateral ureteral obstruction in rats]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 33 (2):305–8.
   PubMedGoogle Scholar
• Xie, W. J., G. Hou, L. Wang, S. S. Wang, and X. X. Xiong. 2020. Astaxanthin suppresses lipopolysaccharide‑induced myocardial injury by regulating MAPK and PI3K/AKT/mTOR/GSK3β signaling. Molecular Medicine Reports 22 (4):3338–46. doi: 10.3892/mmr.2020.11443.
   PubMed Web of Science ®Google Scholar
• Xie, X., Q. Chen, and J. Tao. 2018. Astaxanthin promotes Nrf2/ARE signaling to inhibit HG-induced renal fibrosis in GMCs. Marine Drugs 16 (4):117. doi: 10.3390/md16040117.
   PubMed Web of Science ®Google Scholar
• Xu, J., H. Gao, L. Zhang, C. Chen, W. Yang, Q. Deng, Q. Huang, and F. Huang. 2014. A combination of flaxseed oil and astaxanthin alleviates atherosclerosis risk factors in high fat diet fed rats. Lipids in Health and Disease 13:63. doi: 10.1186/1476-511x-13-63.
   PubMed Web of Science ®Google Scholar
• Xu, L., J. Zhu, W. Yin, and X. Ding. 2015. Astaxanthin improves cognitive deficits from oxidative stress, nitric oxide synthase and inflammation through upregulation of PI3K/Akt in diabetes rat. International Journal of Clinical and Experimental Pathology 8 (6):6083–94.
   PubMed Web of Science ®Google Scholar
• Xu, Y., S. Yao, D. Gao, W. Li, D. Zheng, and Q. Zhang. 2019. Effect of astaxanthin on apoptosis of rat renal tubular epithelial cells induced by iohexol. American Journal of Translational Research 11 (5):3039–47.
   PubMed Web of Science ®Google Scholar
• Xue, Y., Z. Qu, J. Fu, J. Zhen, W. Wang, Y. Cai, and W. Wang. 2017. The protective effect of astaxanthin on learning and memory deficits and oxidative stress in a mouse model of repeated cerebral ischemia/reperfusion. Brain Research Bulletin 131:221–8. doi: 10.1016/j.brainresbull.2017.04.019.
   PubMed Web of Science ®Google Scholar
• Yamaguchi, M. 2012. Role of carotenoid β-cryptoxanthin in bone homeostasis. Journal of Biomedical Science 19 (1):36. doi: 10.1186/1423-0127-19-36.
   PubMedGoogle Scholar
• Yanai, H., K. Ito, H. Yoshida, and N. Tada. 2008. Antihypertensive effects of astaxanthin. Integrated Blood Pressure Control 1:1–3. doi: 10.2147/ibpc.s4094.
   PubMedGoogle Scholar
• Yang, C., Y. I. Hassan, R. Liu, H. Zhang, Y. Chen, L. Zhang, and R. Tsao. 2019. Anti-inflammatory effects of different astaxanthin isomers and the roles of lipid transporters in the cellular transport of astaxanthin isomers in Caco-2 cell monolayers. Journal of Agricultural and Food Chemistry 67 (22):6222–31. doi: 10.1021/acs.jafc.9b02102.
   PubMed Web of Science ®Google Scholar
• Yang, H.-C., and A. B. Fogo. 2014. Fibrosis and renal aging. Kidney International Supplements 4 (1):75–8. doi: 10.1038/kisup.2014.14.
   Web of Science ®Google Scholar
• Yang, M., Y. Chen, T. Zhao, and Z. Wang. 2020. Effect of astaxanthin on metabolic cataract in rats with type 1 diabetes mellitus. Experimental and Molecular Pathology 113:104372. doi: 10.1016/j.yexmp.2020.104372.
   PubMed Web of Science ®Google Scholar
• Yang, X., A. L. Guo, Y. P. Pang, X. J. Cheng, T. Xu, X. R. Li, J. Liu, Y. Y. Zhang, and Y. Liu. 2019. Astaxanthin attenuates environmental tobacco smoke-induced cognitive deficits: A critical role of p38 MAPK. Marine Drugs 17 (1):24. doi: 10.3390/md17010024.
   PubMed Web of Science ®Google Scholar
• Yang, X., H. M. Wei, G. Y. Hu, J. Zhao, L. N. Long, C. J. Li, Z. J. Zhao, H. K. Zeng, and H. Nie. 2020. Combining antioxidant astaxantin and cholinesterase inhibitor huperzine A boosts neuroprotection. Molecular Medicine Reports 21 (3):1043–50. doi: 10.3892/mmr.2020.10920.
   PubMed Web of Science ®Google Scholar
• Yang, Y., M. Bae, B. Kim, Y. K. Park, S. I. Koo, and J. Y. Lee. 2016. Astaxanthin prevents and reverses the activation of mouse primary hepatic stellate cells. The Journal of Nutritional Biochemistry 29:21–6. doi: 10.1016/j.jnutbio.2015.11.005.
   PubMed Web of Science ®Google Scholar
• Yang, Y., M. Bae, Y. K. Park, Y. Lee, T. X. Pham, S. Rudraiah, J. Manautou, S. I. Koo, and J. Y. Lee. 2017a. Histone deacetylase 9 plays a role in the antifibrogenic effect of astaxanthin in hepatic stellate cells. The Journal of Nutritional Biochemistry 40:172–7. doi: 10.1016/j.jnutbio.2016.11.003.
   PubMed Web of Science ®Google Scholar
• Yang, Y., F. Fuentes, L. Shu, C. Wang, D. Pung, W. Li, C. Zhang, Y. Guo, and A. N. Kong. 2017b. Epigenetic CpG methylation of the promoter and reactivation of the expression of GSTP1 by astaxanthin in human prostate LNCaP cells. The AAPS Journal 19 (2):421–30. doi: 10.1208/s12248-016-0016-x.
   PubMed Web of Science ®Google Scholar
• Yang, Y., B. Kim, Y. K. Park, S. I. Koo, and J. Y. Lee. 2015. Astaxanthin prevents TGFβ1-induced pro-fibrogenic gene expression by inhibiting Smad3 activation in hepatic stellate cells. Biochimica et Biophysica Acta 1850 (1):178–85. doi: 10.1016/j.bbagen.2014.10.014.
   PubMed Web of Science ®Google Scholar
• Yang, Y., T. X. Pham, C. J. Wegner, B. Kim, C. S. Ku, Y. K. Park, and J. Y. Lee. 2014. Astaxanthin lowers plasma TAG concentrations and increases hepatic antioxidant gene expression in diet-induced obesity mice. The British Journal of Nutrition 112 (11):1797–804. doi: 10.1017/s0007114514002554.
   PubMed Web of Science ®Google Scholar
• Yang, Y., J. M. Seo, A. Nguyen, T. X. Pham, H. J. Park, Y. Park, B. Kim, R. S. Bruno, and J. Lee. 2011. Astaxanthin-rich extract from the green alga Haematococcus pluvialis lowers plasma lipid concentrations and enhances antioxidant defense in apolipoprotein E knockout mice. The Journal of Nutrition 141 (9):1611–7. doi: 10.3945/jn.111.142109.
   PubMed Web of Science ®Google Scholar
• Yasui, Y., M. Hosokawa, N. Mikami, K. Miyashita, and T. Tanaka. 2011. Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice via modulation of the inflammatory cytokines. Chemico-Biological Interactions 193 (1):79–87. doi: 10.1016/j.cbi.2011.05.006.
   PubMed Web of Science ®Google Scholar
• Yazaki, K., C. Yoshikoshi, S. Oshiro, and S. Yanase. 2011. Supplemental cellular protection by a carotenoid extends lifespan via Ins/IGF-1 signaling in Caenorhabditis elegans. Oxidative Medicine and Cellular Longevity 2011:596240. doi: 10.1155/2011/596240.
   PubMed Web of Science ®Google Scholar
• Ye, Q., B. Huang, X. Zhang, Y. Zhu, and X. Chen. 2012. Astaxanthin protects against MPP(+)-induced oxidative stress in PC12 cells via the HO-1/NOX2 axis. BMC Neuroscience 13 (1):156. doi: 10.1186/1471-2202-13-156.
   PubMedGoogle Scholar
• Ye, Q., X. Zhang, B. Huang, Y. Zhu, and X. Chen. 2013. Astaxanthin suppresses MPP(+)-induced oxidative damage in PC12 cells through a Sp1/NR1 signaling pathway. Marine Drugs 11 (12):1019–34. doi: 10.3390/md11041019.
   PubMedGoogle Scholar
• Yeh, P. T., H. W. Huang, C. M. Yang, W. S. Yang, and C. H. Yang. 2016. Astaxanthin inhibits expression of retinal oxidative stress and inflammatory mediators in streptozotocin-induced diabetic rats. PLoS One 11 (1):e0146438. doi: 10.1371/journal.pone.0146438.
   PubMed Web of Science ®Google Scholar
• Yiannopoulou, K. G., and S. G. Papageorgiou. 2020. Current and future treatments in Alzheimer disease: An update. Journal of Central Nervous System Disease 12:1179573520907397. doi: 10.1177/1179573520907397.
   Web of Science ®Google Scholar
• Yiğit, M., A. Güneş, C. Uğuz, T. Yalçın, L. Tök, A. Öz, and M. Nazıroğlu. 2019. Effects of astaxanthin on antioxidant parameters in ARPE-19 cells on oxidative stress model. International Journal of Ophthalmology 12 (6):930–5. doi: 10.18240/ijo.2019.06.08.
   PubMed Web of Science ®Google Scholar
• Ying, C. J., F. Zhang, X. Y. Zhou, X. T. Hu, J. Chen, X. R. Wen, Y. Sun, K. Y. Zheng, R. X. Tang, and Y. J. Song. 2015. Anti-inflammatory effect of astaxanthin on the sickness behavior induced by diabetes mellitus. Cellular and Molecular Neurobiology 35 (7):1027–37. doi: 10.1007/s10571-015-0197-3.
   PubMed Web of Science ®Google Scholar
• Yoon, H. S., H. H. Cho, S. Cho, S. R. Lee, M. H. Shin, and J. H. Chung. 2014. Supplementating with dietary astaxanthin combined with collagen hydrolysate improves facial elasticity and decreases matrix metalloproteinase-1 and -12 expression: A comparative study with placebo. Journal of Medicinal Food 17 (7):810–6. doi: 10.1089/jmf.2013.3060.
   PubMed Web of Science ®Google Scholar
• Yoshida, H., H. Yanai, K. Ito, Y. Tomono, T. Koikeda, H. Tsukahara, and N. Tada. 2010. Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia. Atherosclerosis 209 (2):520–3. doi: 10.1016/j.atherosclerosis.2009.10.012.
   PubMed Web of Science ®Google Scholar
• Yoshihara, T., T. Sugiura, N. Miyaji, Y. Yamamoto, T. Shibaguchi, R. Kakigi, H. Naito, K. Goto, D. Ohmori, and T. Yoshioka. 2018. Effect of a combination of astaxanthin supplementation, heat stress, and intermittent reloading on satellite cells during disuse muscle atrophy. Journal of Zhejiang University. Science. B 19 (11):844–52. doi: 10.1631/jzus.B1800076.
   PubMed Web of Science ®Google Scholar
• Yoshihara, T., Y. Yamamoto, T. Shibaguchi, N. Miyaji, R. Kakigi, H. Naito, K. Goto, D. Ohmori, T. Yoshioka, and T. Sugiura. 2017. Dietary astaxanthin supplementation attenuates disuse-induced muscle atrophy and myonuclear apoptosis in the rat soleus muscle. The Journal of Physiological Sciences 67 (1):181–90. doi: 10.1007/s12576-016-0453-4.
   PubMed Web of Science ®Google Scholar
• Yoshihisa, Y., T. Andoh, K. Matsunaga, M. U. Rehman, T. Maoka, and T. Shimizu. 2016. Efficacy of astaxanthin for the treatment of atopic dermatitis in a murine model. PLoS One 11 (3):e0152288. doi: 10.1371/journal.pone.0152288.
   PubMed Web of Science ®Google Scholar
• Yoshihisa, Y., M. U. Rehman, and T. Shimizu. 2014. Astaxanthin, a xanthophyll carotenoid, inhibits ultraviolet-induced apoptosis in keratinocytes. Experimental Dermatology 23 (3):178–83. doi: 10.1111/exd.12347.
   PubMed Web of Science ®Google Scholar
• Younossi, Z. M., A. B. Koenig, D. Abdelatif, Y. Fazel, L. Henry, and M. Wymer. 2016. Global epidemiology of nonalcoholic fatty liver disease—Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology 64 (1):73–84. doi: 10.1002/hep.28431.
   PubMed Web of Science ®Google Scholar
• Yu, M. R., S. X. Guo, R. H. Jin, C. G. You, X. G. Wang, and C. M. Han. 2020. [Effect and mechanism of astaxanthin on acute kidney injury in rats with full-thickness burns]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese Journal of Burns 36 (11):1050–9. doi: 10.3760/cma.j.cn501120-20200526-00287.
   PubMedGoogle Scholar
• Yu, T., J. Dohl, Y. Chen, H. G. Gasier, and P. A. Deuster. 2019. Astaxanthin but not quercetin preserves mitochondrial integrity and function, ameliorates oxidative stress, and reduces heat-induced skeletal muscle injury. Journal of Cellular Physiology 234 (8):13292–302. doi: 10.1002/jcp.28006.
   PubMed Web of Science ®Google Scholar
• Yuan, L., P. Liang, Y. Qu, T. An, J. Wang, X. Deng, L. Bai, P. Shen, and D. Bai. 2020. Protective effect of astaxanthin against SnS2 nanoflowers induced testes toxicity by suppressing RIPK1-RIPK3-MLKL signaling in mice. Food and Chemical Toxicology 145:111736. doi: 10.1016/j.fct.2020.111736.
   PubMed Web of Science ®Google Scholar
• Yuri, T., K. Yoshizawa, Y. Emoto, Y. Kinoshita, M. Yuki, and A. Tsubura. 2016. Effects of dietary xanthophylls, canthaxanthin and astaxanthin on N-methyl-N-nitrosourea-induced rat mammary carcinogenesis. In Vivo 30 (6):795–800. doi: 10.21873/invivo.10996.
   PubMed Web of Science ®Google Scholar
• Zhang, J., Q. Z. Wang, S. H. Zhao, X. Ji, J. Qiu, J. Wang, Y. Zhou, Q. Cai, J. Zhang, and H. Q. Gao. 2017a. Astaxanthin attenuated pressure overload-induced cardiac dysfunction and myocardial fibrosis: Partially by activating SIRT1. Biochimica et Biophysica Acta. General Subjects 1861 (7):1715–28. doi: 10.1016/j.bbagen.2017.03.007.
   PubMed Web of Science ®Google Scholar
• Zhang, J., P. Xu, Y. Wang, M. Wang, H. Li, S. Lin, C. Mao, B. Wang, X. Song, and C. Lv. 2015. Astaxanthin prevents pulmonary fibrosis by promoting myofibroblast apoptosis dependent on Drp1-mediated mitochondrial fission. Journal of Cellular and Molecular Medicine 19 (9):2215–31. doi: 10.1111/jcmm.12609.
   PubMed Web of Science ®Google Scholar
• Zhang, J., S. Zhang, J. Bi, J. Gu, Y. Deng, and C. Liu. 2017b. Astaxanthin pretreatment attenuates acetaminophen-induced liver injury in mice. International Immunopharmacology 45:26–33. doi: 10.1016/j.intimp.2017.01.028.
   PubMed Web of Science ®Google Scholar
• Zhang, L., W. Cao, Y. Gao, R. Yang, X. Zhang, J. Xu, and Q. Tang. 2020. Astaxanthin (ATX) enhances the intestinal mucosal functions in immunodeficient mice. Food & Function 11 (4):3371–81. doi: 10.1039/c9fo02555c.
   PubMed Web of Science ®Google Scholar
• Zhang, M., H. Shan, Y. Wang, T. Wang, W. Liu, L. Wang, L. Zhang, P. Chang, W. Dong, X. Chen, et al. 2013. The expression changes of cystathionine-β-synthase in brain cortex after traumatic brain injury. Journal of Molecular Neuroscience 51 (1):57–67. doi: 10.1007/s12031-012-9948-5.
   PubMed Web of Science ®Google Scholar
• Zhang, X., Y. Lu, Q. Wu, H. Dai, W. Li, S. Lv, X. Zhou, X. Zhang, C. Hang, and J. Wang. 2019. Astaxanthin mitigates subarachnoid hemorrhage injury primarily by increasing sirtuin 1 and inhibiting the Toll-like receptor 4 signaling pathway. FASEB Journal 33 (1):722–37. doi: 10.1096/fj.201800642RR.
   PubMed Web of Science ®Google Scholar
• Zhang, X. S., X. Zhang, Q. Wu, W. Li, C. X. Wang, G. B. Xie, X. M. Zhou, J. X. Shi, and M. L. Zhou. 2014a. Astaxanthin offers neuroprotection and reduces neuroinflammation in experimental subarachnoid hemorrhage. The Journal of Surgical Research 192 (1):206–13. doi: 10.1016/j.jss.2014.05.029.
   PubMed Web of Science ®Google Scholar
• Zhang, X. S., X. Zhang, Q. Wu, W. Li, Q. R. Zhang, C. X. Wang, X. M. Zhou, H. Li, J. X. Shi, and M. L. Zhou. 2014b. Astaxanthin alleviates early brain injury following subarachnoid hemorrhage in rats: Possible involvement of Akt/bad signaling. Marine Drugs 12 (8):4291–310. doi: 10.3390/md12084291.
   PubMed Web of Science ®Google Scholar
• Zhang, X. S., X. Zhang, Q. R. Zhang, Q. Wu, W. Li, T. W. Jiang, and C. H. Hang. 2015. Astaxanthin reduces matrix metalloproteinase-9 expression and activity in the brain after experimental subarachnoid hemorrhage in rats. Brain Research 1624:113–24. doi: 10.1016/j.brainres.2015.07.020.
   PubMed Web of Science ®Google Scholar
• Zhang, X. S., X. Zhang, M. L. Zhou, X. M. Zhou, N. Li, W. Li, Z. X. Cong, Q. Sun, Z. Zhuang, C. X. Wang, et al. 2014c. Amelioration of oxidative stress and protection against early brain injury by astaxanthin after experimental subarachnoid hemorrhage. Journal of Neurosurgery 121 (1):42–54. doi: 10.3171/2014.2.jns13730.
   PubMed Web of Science ®Google Scholar
• Zhang, Z., C. Guo, H. Jiang, B. Han, X. Wang, S. Li, Y. Lv, Z. Lv, and Y. Zhu. 2020. Inflammation response after the cessation of chronic arsenic exposure and post-treatment of natural astaxanthin in liver: Potential role of cytokine-mediated cell-cell interactions. Food & Function 11 (10):9252–62. doi: 10.1039/d0fo01223h.
   PubMed Web of Science ®Google Scholar
• Zhao, G., H. Zhong, T. Rao, and Z. Pan. 2020. Metabolomic analysis reveals that the mechanism of astaxanthin improves the osteogenic differentiation potential in bone marrow mesenchymal stem cells. Oxidative Medicine and Cellular Longevity 2020:3427430. doi: 10.1155/2020/3427430.
   PubMed Web of Science ®Google Scholar
• Zhao, J., M. Meng, J. Zhang, L. Li, X. Zhu, L. Zhang, C. Wang, and M. Gao. 2019. Astaxanthin ameliorates renal interstitial fibrosis and peritubular capillary rarefaction in unilateral ureteral obstruction. Molecular Medicine Reports 19 (4):3168–78. doi: 10.3892/mmr.2019.9970.
   PubMed Web of Science ®Google Scholar
• Zhou, Q., J. Xu, L. Yang, C. Gu, and C. Xue. 2019. Thermal stability and oral absorbability of astaxanthin esters from Haematococcus pluvialis in Balb/c mice. Journal of the Science of Food and Agriculture 99 (7):3662–71. doi: 10.1002/jsfa.9588.
   PubMed Web of Science ®Google Scholar
• Zhou, Q., L. Yang, J. Xu, X. Qiao, Z. Li, Y. Wang, and C. Xue. 2018. Evaluation of the physicochemical stability and digestibility of microencapsulated esterified astaxanthins using in vitro and in vivo models. Food Chemistry 260:73–81. doi: 10.1016/j.foodchem.2018.03.046.
   PubMed Web of Science ®Google Scholar
• Zhou, T., X. Wang, Y. Ju, C. Shi, and G. Kan. 2018. Stability application and research of astaxanthin integrated into food. IOP Conference Series: Materials Science and Engineering 394:022007. doi: 10.1088/1757-899X/394/2/022007.
   Google Scholar
• Zhou, X., F. Zhang, X. Hu, J. Chen, X. Wen, Y. Sun, Y. Liu, R. Tang, K. Zheng, and Y. Song. 2015. Inhibition of inflammation by astaxanthin alleviates cognition deficits in diabetic mice. Physiology & Behavior 151:412–20. doi: 10.1016/j.physbeh.2015.08.015.
   PubMed Web of Science ®Google Scholar
• Zhou, X. Y., F. Zhang, X. T. Hu, J. Chen, R. X. Tang, K. Y. Zheng, and Y. J. Song. 2017. Depression can be prevented by astaxanthin through inhibition of hippocampal inflammation in diabetic mice. Brain Research 1657:262–8. doi: 10.1016/j.brainres.2016.12.018.
   PubMed Web of Science ®Google Scholar
• Zhou, Y., and D. Lagares. 2021. Anti-aging therapy for pulmonary fibrosis. Nature Aging 1 (2):155–6. doi: 10.1038/s43587-021-00035-5.
   PubMedGoogle Scholar
• Zhu, X., Y. Chen, Q. Chen, H. Yang, and X. Xie. 2018. Astaxanthin promotes Nrf2/ARE signaling to alleviate renal fibronectin and collagen IV accumulation in diabetic rats. Journal of Diabetes Research 2018:6730315. doi: 10.1155/2018/6730315.
   PubMed Web of Science ®Google Scholar
• Zolnourian, A., I. Galea, and D. Bulters. 2019. Neuroprotective role of the Nrf2 pathway in subarachnoid haemorrhage and its therapeutic potential. Oxidative Medicine and Cellular Longevity 2019:6218239. doi: 10.1155/2019/6218239.
   PubMed Web of Science ®Google Scholar
• Zou, T. B., S. S. Zhu, F. Luo, W. Q. Li, X. R. Sun, and H. F. Wu. 2017. Effects of astaxanthin on reverse cholesterol transport and atherosclerosis in mice. BioMed Research International 2017:4625932. doi: 10.1155/2017/4625932.
   PubMed Web of Science ®Google Scholar
• Zuluaga Tamayo, M., L. Choudat, R. Aid-Launais, O. Thibaudeau, L. Louedec, D. Letourneur, V. Gueguen, A. Meddahi-Pellé, A. Couvelard, and G. Pavon-Djavid. 2019. Astaxanthin complexes to attenuate muscle damage after in vivo femoral ischemia-reperfusion. Marine Drugs 17 (6):354. doi: 10.3390/md17060354.
   PubMed Web of Science ®Google Scholar