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Review

Food for healthier aging: power on your plate

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References

  • Abiri, B., and M. Vafa. 2020. Micronutrients that affect immunosenescence. Advances in Experimental Medicine and Biology 1260:13–31. doi: 10.1007/978-3-030-42667-5_2.
  • Afshin, A.,. P. J. Sur, K. A. Fay, L. Cornaby, G. Ferrara, J. S. Salama, E. C. Mullany, K. H. Abate, C. Abbafati, Z. Abebe, et al. 2019. Health effects of dietary risks in 195 countries, 1990-2017: A ­systematic analysis for the global burden of disease study 2017. The Lancet 393 (10184):1958–72. doi: 10.1016/S0140-6736(19)30041-8.
  • Agodi, A., M. Barchitta, A. Quattrocchi, A. Maugeri, C. Canto, A. E. Marchese, and M. Vinciguerra. 2015. Low fruit consumption and folate deficiency are associated with LINE-1 hypomethylation in women of a cancer-free population. Genes & Nutrition 10 (5):480. doi: 10.1007/s12263-015-0480-4.
  • Alonso-Pedrero, L., A. Ojeda-Rodríguez, M. A. Martínez-González, G. Zalba, M. Bes-Rastrollo, and A. Marti. 2020. Ultra-processed food consumption and the risk of short telomeres in an elderly population of the Seguimiento Universidad de Navarra (SUN) Project. The American Journal of Clinical Nutrition 111 (6):1259–66. doi: 10.1093/ajcn/nqaa075.
  • Alvarenga, L., L. F. M. F. Cardozo, B. Lindholm, P. Stenvinkel, and D. Mafra. 2020. Intestinal alkaline phosphatase modulation by food components: Predictive, preventive, and personalized strategies for novel treatment options in chronic kidney disease. The EPMA Journal 11 (4):565–79. doi: 10.1007/S13167-020-00228-9.
  • Alvarenga, L., L. F. M. F. Cardozo, N. A. Borges, B. Lindholm, P. Stenvinkel, P. G. Shiels, D. Fouque, and D. Mafra. 2020. Can nutritional interventions modulate the activation of the NLRP3 inflammasome in chronic kidney disease? Food Research International (Ottawa, Ont.) 136:109306. doi: 10.1016/j.foodres.2020.109306.
  • Alvarenga, L., L. F. M. F. Cardozo, N. A. Borges, B. Lindholm, P. Stenvinkel, P. G. Shiels, D. Fouque, and D. Mafra. 2020. Can nutritional interventions modulate the activation of the NLRP3 inflammasome in chronic kidney disease? Food Research International (Ottawa, Ont.) 136 (October):109306. Food Res Int. doi: 10.1016/j.foodres.2020.109306.
  • Arefin, S., S. Buchanan, S. Hobson, J. Steinmetz, S. Alsalhi, P. G. Shiels, K. Kublickiene, and P. Stenvinkel. 2020. Nrf2 in early vascular ageing: calcification, senescence and therapy. Clinica Chimica Acta; International Journal of Clinical Chemistry 505 (June):108–18. doi: 10.1016/J.CCA.2020.02.026.
  • Bai, Z., and Z. Wang. 2019. Genistein protects against doxorubicin-induced cardiotoxicity through Nrf-2/HO-1 signaling in mice model. Environmental Toxicology 34 (5):645–51. doi: 10.1002/TOX.22730.
  • Barreca, D., E. Bellocco, G. Laganà, G. Ginestra, and C. Bisignano. 2014. Biochemical and antimicrobial activity of phloretin and its glycosilated derivatives present in apple and kumquat. Food Chemistry 160 (October):292–7. doi: 10.1016/J.FOODCHEM.2014.03.118.
  • Biagi, E., C. Franceschi, S. Rampelli, M. Severgnini, R. Ostan, S. Turroni, C. Consolandi, S. Quercia, M. Scurti, D. Monti, et al. 2016. Gut microbiota and extreme longevity. Current Biology: CB 26 (11):1480–5. doi: 10.1016/J.CUB.2016.04.016.
  • Bischoff, S. C. 2016. Microbiota and aging. Current Opinion in Clinical Nutrition and Metabolic Care 19 (1):26–30. doi: 10.1097/MCO.0000000000000242.
  • Blackwell, T. K., M. J. Steinbaugh, J. M. Hourihan, C. Y. Ewald, and M. Isik. 2015. SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans. Free Radical Biology & Medicine 88 (Pt B):290–301. doi: 10.1016/J.FREERADBIOMED.2015.06.008.
  • Blasiak, J., J. Chojnacki, E. Pawlowska, J. Szczepanska, and C. Chojnacki. 2020. Nutrition in cancer therapy in the elderly—An epigenetic connection? Nutrients 12 (11):3366. doi: 10.3390/nu12113366.
  • Borges, N. A., F. L. Carmo, M. B. Stockler-Pinto, J. S. de Brito, C. J. Dolenga, D. C. Ferreira, L. S. Nakao, A. Rosado, D. Fouque, and D. Mafra. 2018. Probiotic supplementation in chronic kidney disease: A double-blind, randomized, placebo-controlled trial. Journal of Renal Nutrition: The Official Journal of the Council on Renal Nutrition of the National Kidney Foundation 28 (1):28–36. doi: 10.1053/J.JRN.2017.06.010.
  • Buettner, D. 2015. The blue zones solution: Eating and living like the world’s healthiest people. Washington, D.C: National Geographic Books.
  • Candela, M., E. Biagi, P. Brigidi, P. W. O’Toole, and W. M. De Vos. 2014. Maintenance of a healthy trajectory of the intestinal microbiome during aging: A dietary approach. Mechanisms of Ageing and Development 136-137:70–5. doi: 10.1016/j.mad.2013.12.004.
  • Cardozo, L. F. M. F., L. A. Alvarenga, M. Ribeiro, L. Dai, P. G. Shiels, P. Stenvinkel, B. Lindholm, and D. Mafra. 2021. Cruciferous vegetables: Rationale for exploring potential salutary effects of sulforaphane-rich foods in patients with chronic kidney disease. Nutrition Reviews 79 (11):1204–24. doi: 10.1093/nutrit/nuaa129.
  • Chan, A. H., and K. Schroder. 2020. Inflammasome signaling and regulation of interleukin-1 family cytokines. Journal of Experimental Medicine 217 (1):e20190314. doi: 10.1084/jem.20190314.
  • Chandrasekaran, A., M. del Pilar Sosa Idelchik, and J. A. Melendez. 2017. Redox control of senescence and age-related disease. Redox Biology 11 (April):91–102. doi: 10.1016/J.REDOX.2016.11.005.
  • Chauhan, A., M. Jang, and Y. Kim. 2020. Phloretin protects macrophages from E. coli-induced inflammation through the TLR4 signaling pathway. Journal of Microbiology and Biotechnology 30 (3):333–40. doi: 10.4014/JMB.1910.10063.
  • Claesson, M. J., I. B. Jeffery, S. Conde, S. E. Power, E. M. O’Connor, S. Cusack, H. M. B. Harris, M. Coakley, B. Lakshminarayanan, O. O’Sullivan, et al. 2012. Gut microbiota composition correlates with diet and health in the elderly. Nature 488 (7410):178–84. doi: 10.1038/NATURE11319.
  • Collino, S., I. Montoliu, F.-P J. Martin, M. Scherer, D. Mari, S. Salvioli, L. Bucci, R. Ostan, D. Monti, E. Biagi, et al. 2013. Metabolic signatures of extreme longevity in Northern Italian centenarians reveal a complex remodeling of lipids, amino acids, and gut microbiota metabolism. PloS One 8 (3):e56564. doi: 10.1371/JOURNAL.PONE.0056564.
  • Costantini, L., R. Molinari, B. Farinon, and N. Merendino. 2017. Impact of omega-3 fatty acids on the gut microbiota. International Journal of Molecular Sciences 18 (12):2645. doi: 10.3390/ijms18122645.
  • Cruz-Mora, J., N. E. Martínez-Hernández, F. Martín del Campo-López, D. Viramontes-Hörner, B. Vizmanos-Lamotte, J. F. Muñoz-Valle, G. García-García, I. Parra-Rojas, and N. Castro-Alarcón. 2014. Effects of a symbiotic on gut microbiota in Mexican patients with end-stage renal disease. Journal of Renal Nutrition: The Official Journal of the Council on Renal Nutrition of the National Kidney Foundation 24 (5):330–5. doi: 10.1053/J.JRN.2014.05.006.
  • Csiszar, A., D. Sosnowska, M. Wang, E. G. Lakatta, W. E. Sonntag, and Z. Ungvari. 2012. Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: Reversal by resveratrol treatment. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 67 (8):811–20. doi: 10.1093/GERONA/GLR228.
  • Cuadrado, A., A. I. Rojo, G. Wells, J. D. Hayes, S. P. Cousin, W. L. Rumsey, O. C. Attucks, S. Franklin, A.-L. Levonen, T. W. Kensler, et al. 2019. Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases. Nature Reviews. Drug Discovery 18 (4):295–317. doi: 10.1038/S41573-018-0008-X.
  • Cui, J., P. Xia, L. Zhang, Y. Hu, Q. Xie, and H. Xiang. 2020. A novel fermented soybean, inoculated with selected Bacillus, Lactobacillus and Hansenula strains, showed strong antioxidant and anti-fatigue potential activity. Food Chemistry 333 (December):127527. doi: 10.1016/J.FOODCHEM.2020.127527.
  • Dagher, O., P. Mury, P.-E. Noly, A. Fortier, G. Lettre, E. Thorin, and M. Carrier. 2021. Design of a randomized placebo-controlled trial to evaluate the anti-inflammatory and senolytic effects of quercetin in patients undergoing coronary artery bypass graft surgery. Frontiers in Cardiovascular Medicine 8 (October):741542. doi: 10.3389/FCVM.2021.741542.
  • Das, S. K., S. B. Roberts, M. V. Bhapkar, D. T. Villareal, L. Fontana, C. K. Martin, S. B. Racette, P. J. Fuss, W. E. Kraus, W. W. Wong, et al. 2017. Body-composition changes in the comprehensive assessment of long-term effects of reducing intake of energy (CALERIE)-2 study: A 2-y randomized controlled trial of calorie restriction in nonobese humans. The American Journal of Clinical Nutrition 105 (4):913–27. doi: 10.3945/ajcn.116.137232.
  • De Almeida Alvarenga, L., N. A. Borges, L. D. S. G. Moreira, K. T. Resende Teixeira, J. C. Carraro-Eduardo, L. Dai, P. Stenvinkel, B. Lindholm, and D. Mafra. 2019. Cranberries-potential benefits in patients with chronic kidney disease. Food & Function 10 (6):3103–12. doi: 10.1039/C9FO00375D.
  • De Magalhães, J. P. 2013. How ageing processes influence cancer. Nature Reviews. Cancer 13 (5):357–65. doi: 10.1038/NRC3497.
  • Dimri, G. P., K. Itahana, M. Acosta, and J. Campisi. 2000. Regulation of a senescence checkpoint response by the E2F1 transcription factor and P14(ARF) tumor suppressor. Molecular and Cellular Biology 20 (1):273–85. doi: 10.1128/MCB.20.1.273-285.2000.
  • Dimri, G. P., X. Lee, G. Basile, M. Acosta, G. Scott, C. Roskelley, E. E. Medrano, M. Linskens, I. Rubelj, O. Pereira-Smith, et al. 1995. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proceedings of the National Academy of Sciences of the United States of America 92 (20):9363–7. doi: 10.1073/PNAS.92.20.9363.
  • Dong, Z., H. Shang, Y. Q. Chen, L.-L. Pan, M. Bhatia, and J. Sun. 2016. Sulforaphane protects pancreatic acinar cell injury by modulating Nrf2-mediated oxidative stress and NLRP3 inflammatory pathway. Oxidative Medicine and Cellular Longevity 2016:7864150. doi: 10.1155/2016/7864150.
  • Ebert, T., S. C. Pawelzik, A. Witasp, S. Arefin, S. Hobson, K. Kublickiene, P. G. Shiels, M. Bäck, and P. Stenvinkel. 2020. Inflammation and premature ageing in chronic kidney disease. Toxins 12 (4):227. doi: 10.3390/toxins12040227.
  • Esgalhado, M., J. A. Kemp, B. R. De Paiva, J. S. Brito, L. F. M. F. Cardozo, R. Azevedo, D. B. Cunha, L. S. Nakao, and D. Mafra. 2020. Resistant starch type-2 enriched cookies modulate uremic toxins and inflammation in hemodialysis patients: A randomized, double-blind, crossover and placebo-controlled trial. Food & Function 11 (3):2617–25. doi: 10.1039/c9fo02939g.
  • Esmaeil, N., S. Balouchi Anaraki, M. Gharagozloo, and B. Moayedi. 2017. Silymarin impacts on immune system as an immunomodulator: One key for many locks. International Immunopharmacology 50 (September):194–201. doi: 10.1016/J.INTIMP.2017.06.030.
  • Ferrucci, L., and E. Fabbri. 2018. Inflammageing: Chronic inflammation in ageing, cardiovascular disease, and frailty. Nature Reviews. Cardiology 15 (9):505–22. doi: 10.1038/S41569-018-0064-2.
  • Fontana, L. 2009. Neuroendocrine factors in the regulation of inflammation: Excessive adiposity and calorie restriction. Experimental Gerontology 44 (1-2):41–5. doi: 10.1016/J.EXGER.2008.04.005.
  • Fontana, L., T. E. Meyer, S. Klein, and J. O. Holloszy. 2004. Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. Proceedings of the National Academy of Sciences of the United States of America 101 (17): :6659–63. doi: 10.1073/PNAS.0308291101.
  • Fontana, L., D. T. Villareal, E. P. Weiss, S. B. Racette, K. Steger-May, S. Klein, and J. O. Holloszy. 2007. Calorie restriction or exercise: Effects on coronary heart disease risk factors. A randomized, controlled trial. American Journal of Physiology. Endocrinology and Metabolism 293 (1):E197–202. doi: 10.1152/AJPENDO.00102.2007.
  • Franceschi, C., P. Garagnani, P. Parini, C. Giuliani, and A. Santoro. 2018. Inflammaging: A new immune–metabolic viewpoint for age-related diseases. Nature Reviews. Endocrinology 14 (10):576–90. doi: 10.1038/s41574-018-0059-4.
  • Fransen, F.,. A. A. van Beek, T. Borghuis, S. E. Aidy, F. Hugenholtz, C. van der Gaast-de Jongh, H. F. J. Savelkoul, M. I. De Jonge, M. V. Boekschoten, H. Smidt, et al. 2017. Aged gut microbiota contributes to systemical inflammaging after transfer to germ-free mice. Frontiers in Immunology 8 (November):1385. doi: 10.3389/fimmu.2017.01385.
  • Franzago, M., D. Santurbano, E. Vitacolonna, and L. Stuppia. 2020. Genes and diet in the prevention of chronic diseases in future generations. International Journal of Molecular Sciences 21 (7):2633. doi: 10.3390/ijms21072633.
  • Freitas-Simoes, T.-M., E. Ros, and A. Sala-Vila. 2018. Telomere length as a biomarker of accelerated aging: Is it influenced by dietary intake? Current Opinion in Clinical Nutrition and Metabolic Care 21 (6):430–6. doi: 10.1097/MCO.0000000000000506.
  • Garcia-Mantrana, I., M. Selma-Royo, C. Alcantara, and M. C. Collado. 2018. Shifts on gut microbiota associated to Mediterranean diet adherence and specific dietary intakes on general adult population. Frontiers in Microbiology 9 (May):890. doi: 10.3389/fmicb.2018.00890.
  • Ge, Y., W. Liu, H. Tao, Y. Zhang, L. Liu, Z. Liu, B. Qiu, and T. Xu. 2019. Effect of industrial trans-fatty acids-enriched diet on gut microbiota of C57BL/6 mice. European Journal of Nutrition 58 (7):2625–38. doi: 10.1007/S00394-018-1810-2.
  • Gebert, N., C.-W. Cheng, J. M. Kirkpatrick, D. Di Fraia, J. Yun, P. Schädel, S. Pace, G. B. Garside, O. Werz, K. L. Rudolph, et al. 2020. Region-specific proteome changes of the intestinal epithelium during aging and dietary restriction. Cell Reports 31 (4): :107565. doi: 10.1016/J.CELREP.2020.107565.
  • Gensous, N., P. Garagnani, A. Santoro, C. Giuliani, R. Ostan, C. Fabbri, M. Milazzo, D. Gentilini, A. M. di Blasio, B. Pietruszka, et al. 2020. One-year Mediterranean diet promotes epigenetic rejuvenation with country- and sex-specific effects: A pilot study from the NU-AGE Project. GeroScience 42 (2):687–701. doi: 10.1007/s11357-019-00149-0.
  • Ghosh, T. S., M. Das, I. B. Jeffery, and P. W. O’Toole. 2020. Adjusting for age improves identification of gut microbiome alterations in multiple diseases. eLife 9 (March):e50240. doi: 10.7554/eLife.50240.
  • Golovinskaia, O., and C. K. Wang. 2021. Review of functional and pharmacological activities of berries. Molecules (Basel, Switzerland) 26 (13):3904. doi: 10.3390/molecules26133904.
  • Gong, Y., X. Cao, L. Gong, and W. Li. 2019. Sulforaphane alleviates retinal ganglion cell death and inflammation by suppressing Nlrp3 inflammasome activation in a rat model of retinal ischemia/reperfusion injury. International Journal of Immunopathology and Pharmacology 33:2058738419861777. doi: 10.1177/2058738419861777.
  • Graf, D., R. Di Cagno, F. Fåk, H. J. Flint, M. Nyman, M. Saarela, and B. Watzl. 2015. Contribution of diet to the composition of the human gut microbiota. Microbial Ecology in Health and Disease 26 (February):26164. doi: 10.3402/MEHD.V26.26164.
  • Gregory, J. C., J. A. Buffa, E. Org, Z. Wang, B. S. Levison, W. Zhu, M. A. Wagner, B. J. Bennett, L. Li, J. A. DiDonato, et al. 2015. Transmission of atherosclerosis susceptibility with gut microbial transplantation. The Journal of Biological Chemistry 290 (9) :5647–60. doi: 10.1074/JBC.M114.618249.
  • Hayflick, L., and P. S. Moorhead. 1961. The serial cultivation of human diploid cell strains. Experimental Cell Research 25 (3):585–621. doi: 10.1016/0014-4827(61)90192-6.
  • He, F., X. Ru, and T. Wen. 2020. NRF2, a transcription factor for stress response and beyond. International Journal of Molecular Sciences 21 (13):4777–23. doi: 10.3390/ijms21134777.
  • Hine, C., Y. Zhu, A. N. Hollenberg, and J. R. Mitchell. 2018. Dietary and endocrine regulation of endogenous hydrogen sulfide production: Implications for longevity. Antioxidants & Redox Signaling 28 (16):1483–502. doi: 10.1089/ARS.2017.7434.
  • Hou, Y., X. Dan, M. Babbar, Y. Wei, S. G. Hasselbalch, D. L. Croteau, and V. A. Bohr. 2019. Ageing as a risk factor for neurodegenerative disease. Nature Reviews. Neurology 15 (10):565–81. doi: 10.1038/S41582-019-0244-7.
  • Kim, K.-A., J.-J. Jeong, S.-Y. Yoo, and D.-H. Kim. 2016. Gut microbiota lipopolysaccharide accelerates inflamm-aging in mice. BMC Microbiology 16 (January):9. doi: 10.1186/S12866-016-0625-7.
  • Kim, Y. J., D. H. Lee, J. Ahn, W. J. Chung, Y. J. Jang, K. S. Seong, J. H. Moon, T. Y. Ha, and C. H. Jung. 2015. Pharmacokinetics, tissue distribution, and anti-lipogenic/adipogenic effects of allyl-isothiocyanate metabolites. PLoS ONE 10 (8):e0132151. doi: 10.1371/journal.pone.0132151.
  • Kirkland, J. L., T. Tchkonia, Y. Zhu, L. J. Niedernhofer, and P. D. Robbins. 2017. The clinical potential of senolytic drugs. Journal of the American Geriatrics Society 65 (10):2297–301. doi: 10.1111/JGS.14969.
  • Kong, F., Y. Hua, B. Zeng, R. Ning, Y. Li, and J. Zhao. 2016. Gut microbiota signatures of longevity. Current Biology : CB 26 (18):R832–R833. doi: 10.1016/J.CUB.2016.08.015.
  • Kooman, J. P., M. J. Dekker, L. A. Usvyat, P. Kotanko, F. M. van der Sande, C. G. Schalkwijk, P. G. Shiels, and P. Stenvinkel. 2017. Inflammation and premature aging in advanced chronic kidney disease. American Journal of Physiology. Renal Physiology 313 (4):F938–F950. doi: 10.1152/AJPRENAL.00256.2017.
  • Kooman, J. P., P. Kotanko, A. M. W. J. Schols, P. G. Shiels, and P. Stenvinkel. 2014. Chronic kidney disease and premature ageing. Nature Reviews Nephrology 10 (12):732–42. doi: 10.1038/nrneph.2014.185.
  • Koppula, S., M. Akther, M. E. Haque, and S. R. Kopalli. 2021. Potential nutrients from natural and synthetic sources targeting inflammaging-a review of literature, clinical data and patents. Nutrients 13 (11):4058. doi: 10.3390/nu13114058.
  • Krishnamurthy, J., M. R. Ramsey, K. L. Ligon, C. Torrice, A. Koh, S. Bonner-Weir, and N. E. Sharpless. 2006. P16INK4a induces an age-dependent decline in islet regenerative potential. Nature 443 (7110):453–7. doi: 10.1038/NATURE05092.
  • Kühn, F., F. Adiliaghdam, P. M. Cavallaro, S. R. Hamarneh, A. Tsurumi, R. S. Hoda, A. R. Munoz, Y. Dhole, J. M. Ramirez, E. Liu, et al. 2020. Intestinal alkaline phosphatase targets the gut barrier to prevent aging. JCI Insight 5 (6):e134049. doi: 10.1172/jci.insight.134049.
  • Larrick, J. W., and A. R. Mendelsohn. 2020. Supplementation with brush border enzyme alkaline phosphatase slows aging. Rejuvenation Research 23 (2):171–5. doi: 10.1089/REJ.2020.2335.
  • Lee, M. B., C. M. Hill, A. Bitto, and M. Kaeberlein. 2021. Antiaging diets: Separating fact from fiction. Science (New York, N.Y.) 374 (6570):eabe7365. doi: 10.1126/SCIENCE.ABE7365.
  • Lee, S., K. I. Keirsey, R. Kirkland, Z. I. Grunewald, J. G. Fischer, and C. B. de La Serre. 2018. Blueberry supplementation influences the gut microbiota, inflammation, and insulin resistance in high-fat-diet-fed rats. The Journal of Nutrition 148 (2):209–19. doi: 10.1093/jn/nxx027.
  • Leon, K. E., N. K. Tangudu, K. M. Aird, and R. Buj. 2021. Loss of P16: A bouncer of the immunological surveillance? Life (Basel, Switzerland) 11 (4):309. doi: 10.3390/life11040309.
  • Lim, S. S., T. Vos, A. D. Flaxman, G. Danaei, K. Shibuya, H. Adair-Rohani, M. A. AlMazroa, M. Amann, H. R. Anderson, K. G. Andrews, et al. 2012. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: A systematic analysis for the global burden of disease study 2010. The Lancet 380 (9859):2224–60. doi: 10.1016/S0140-6736(12)61766-8.
  • Limtrakul, P., S. Yodkeeree, P. Pitchakarn, and W. Punfa. 2016. Anti-inflammatory effects of proanthocyanidin-rich red rice extract via suppression of MAPK, AP-1 and NF-ΚB pathways in raw 264.7 macrophages. Nutrition Research and Practice 10 (3) :251–8. doi: 10.4162/NRP.2016.10.3.251.
  • Lobel, L.,. Y. G. Cao, K. Fenn, J. N. Glickman, and W. S. Garrett. 2020. Diet posttranslationally modifies the mouse gut microbial proteome to modulate renal function. Science (New York, N.Y.) 369 (6510):1518–24. doi: 10.1126/SCIENCE.ABB3763.
  • López-Otín, C., M. A. Blasco, L. Partridge, M. Serrano, and G. Kroemer. 2013. The hallmarks of aging. Cell 153 (6):1194–217. doi: 10.1016/j.cell.2013.05.039.
  • Ma, J., Rebholz, C. M. Kim, V. E. Braun, L. M. Reynolds, S. Aslibekyan, R. Xia, N. G. Biligowda, et al. 2020. Whole blood DNA methylation signatures of diet are associated with cardiovascular disease risk factors and all-cause mortality. Circulation. Genomic and Precision Medicine 13 (4):324–33. doi: 10.1161/CIRCGEN.119.002766.
  • Madsen, L., L. S. Myrmel, E. Fjaere, B. Liaset, and K. Kristiansen. 2017. Links between dietary protein sources, the gut microbiota, and obesity. Frontiers in Physiology 8 (December)Front Physiol: :1047. doi: 10.3389/FPHYS.2017.01047.
  • Maduro, A. T., C. Luís, and R. Soares. 2021. Ageing, cellular senescence and the impact of diet: An overview. Porto Biomedical Journal 6 (1):e120. doi: 10.1097/j.pbj.0000000000000120.
  • Mafra, D., N. A. Borges, L. Alvarenga, M. Ribeiro, L. Fonseca, V. O. Leal, P. G. Shiels, and P. Stenvinkel. 2022. Fermented food: Should patients with cardiometabolic diseases go back to an early neolithic diet? Critical Reviews in Food Science and Nutrition 62:1–24. doi: 10.1080/10408398.2022.2077300.
  • Mafra, D., N. Borges, L. Alvarenga, M. Esgalhado, L. Cardozo, B. Lindholm, and P. Stenvinkel. 2019. Dietary components that may influence the disturbed gut microbiota in chronic kidney disease. Nutrients 11 (3):496. doi: 10.3390/nu11030496.
  • Mafra, D., A. F. Barros, and D. Fouque. 2013. Dietary protein metabolism by gut microbiota and its consequences for chronic kidney disease patients. Future Microbiology 8 (10):1317–23. doi: 10.2217/FMB.13.103.
  • Mafra, D., N. A. Borges, B. Lindholm, P. G. Shiels, P. Evenepoel, and P. Stenvinkel. 2021. Food as medicine: Targeting the uraemic phenotype in chronic kidney disease. Nature Reviews. Nephrology 17 (3):153–71. doi: 10.1038/s41581-020-00345-8.
  • Mager, L. F., R. Burkhard, N. Pett, N. C. A. Cooke, K. Brown, H. Ramay, S. Paik, J. Stagg, R. A. Groves, M. Gallo, et al. 2020. Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy. Science (New York, N.Y.) 369 (6510):1481–9. doi: 10.1126/SCIENCE.ABC3421.
  • Maher, P. 2015. How fisetin reduces the impact of age and disease on CNS function. Frontiers in Bioscience 7 (1)Front Biosci (Schol Ed): :58–82. doi: 10.2741/s425.
  • Margină, D., A. Ungurianu, C. Purdel, D. Tsoukalas, E. Sarandi, M. Thanasoula, F. Tekos, R. Mesnage, D. Kouretas, and A. Tsatsakis. 2020. Chronic inflammation in the context of everyday life: Dietary changes as mitigating factors. International Journal of Environmental Research and Public Health 17 (11):4135. doi: 10.3390/ijerph17114135.
  • Marques-Rocha, J. L., F. I. Milagro, M. L. Mansego, M. A. Zulet, J. Bressan, and J. A. Martínez. 2016. Expression of inflammation-related MiRNAs in white blood cells from subjects with metabolic syndrome after 8 wk of following a Mediterranean diet-based weight loss program. Nutrition (Burbank, Los Angeles County, Calif.) 32 (1):48–55. doi: 10.1016/J.NUT.2015.06.008.
  • Martínez, G., M. R. Mijares, and J. B. De Sanctis. 2019. Effects of flavonoids and its derivatives on immune cell responses. Recent Patents on Inflammation & Allergy Drug Discovery 13 (2):84–104. doi: 10.2174/1872213X13666190426164124.
  • McFarlane, C., C. I. Ramos, D. W. Johnson, and K. L. Campbell. 2019. Prebiotic, probiotic, and synbiotic supplementation in chronic kidney disease: A systematic review and meta-analysis. Journal of Renal Nutrition: The Official Journal of the Council on Renal Nutrition of the National Kidney Foundation 29 (3):209–20. doi: 10.1053/J.JRN.2018.08.008.
  • McHugh, D., and J. Gil. 2018. Senescence and aging: Causes, consequences, and therapeutic avenues. The Journal of Cell Biology 217 (1):65–77. doi: 10.1083/jcb.201708092.
  • Moraes, C., N. A. Borges, and D. Mafra. 2016. Resistant starch for modulation of gut microbiota: Promising adjuvant therapy for chronic kidney disease patients? European Journal of Nutrition 55 (5):1813–21. doi: 10.1007/S00394-015-1138-0.
  • Most, J., V. Tosti, L. M. Redman, and L. Fontana. 2017. Calorie restriction in humans: An update. Ageing Research Reviews 39 (October):36–45. doi: 10.1016/J.ARR.2016.08.005.
  • Mozos, I., D. Jianu, D. Stoian, C. Mozos, C. Gug, M. Pricop, O. Marginean, and C. T. Luca. 2021. The Relationship Between Dietary Choices and Health and Premature Vascular Ageing. Heart, Lung & Circulation 30 (11)Heart Lung Circ: :1647–57. doi: 10.1016/J.HLC.2021.07.009.
  • Nabavi, S. F., A. J. Barber, C. Spagnuolo, G. L. Russo, M. Daglia, S. M. Nabavi, and E. Sobarzo-Sánchez. 2016. Nrf2 as molecular target for polyphenols: A novel therapeutic strategy in diabetic retinopathy. Critical Reviews in Clinical Laboratory Sciences 53 (5):293–312. doi: 10.3109/10408363.2015.1129530.
  • Nekoukar, Z., M. Moghimi, and E. Salehifar. 2021. A narrative review on adverse effects of dasatinib with a focus on pharmacotherapy of dasatinib-induced pulmonary toxicities. Blood Research 56 (4):229–42. doi: 10.5045/BR.2021.2021117.
  • Nemet, I., P. P. Saha, N. Gupta, W. Zhu, K. A. Romano, S. M. Skye, T. Cajka, M. L. Mohan, L. Li, Y. Wu, et al. 2020. A cardiovascular disease-linked gut microbial metabolite acts via adrenergic receptors. Cell 180 (5):862–77.e22. doi: 10.1016/J.CELL.2020.02.016.
  • Nyangale, E. P., D. S. Mottram, and G. R. Gibson. 2012. Gut microbial activity, implications for health and disease: The potential role of metabolite analysis. Journal of Proteome Research 11 (12):5573–85. doi: 10.1021/PR300637D.
  • O’Toole, P. W., and P. G. Shiels. 2020. The role of the microbiota in sedentary lifestyle disorders and ageing: Lessons from the animal kingdom. Journal of Internal Medicine 287 (3):271–82. doi: 10.1111/JOIM.13021.
  • Ozdal, T., D. A. Sela, J. Xiao, D. Boyacioglu, F. Chen, and E. Capanoglu. 2016. The reciprocal interactions between polyphenols and gut microbiota and effects on bioaccessibility. Nutrients 8 (2):78. doi: 10.3390/NU8020078.
  • Pappalardo, X. G., and V. Barra. 2021. Losing DNA methylation at repetitive elements and breaking bad. Epigenetics & Chromatin 14 (1):25. doi: 10.1186/S13072-021-00400-Z.
  • Poulain, M., A. Herm, A. Errigo, C. Chrysohoou, R. Legrand, G. Passarino, M. A. Stazi, K. G. Voutekatis, E. S. Gonos, C. Franceschi, et al. 2021. Specific features of the oldest old from the longevity blue zones in ikaria and sardinia. Mechanisms of Ageing and Development 198 (September):111543. doi: 10.1016/j.mad.2021.111543.
  • Rafie, N., S. Golpour Hamedani, F. Barak, S. M. Safavi, and M. Miraghajani. 2017. Dietary patterns, food groups and telomere length: A systematic review of current studies. European Journal of Clinical Nutrition 71 (2):151–8. doi: 10.1038/EJCN.2016.149.
  • Rahman, M. M., G. P. Sykiotis, M. Nishimura, R. Bodmer, and D. Bohmann. 2013. Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes. Aging Cell 12 (4):554–62. doi: 10.1111/ACEL.12078.
  • Rampelli, S., M. Candela, S. Turroni, E. Biagi, S. Collino, C. Franceschi, P. W. O’Toole, and P. Brigidi. 2013. Functional metagenomic profiling of intestinal microbiome in extreme ageing. Aging 5 (12):902–12. doi: 10.18632/AGING.100623.
  • Rampelli, S., M. Soverini, F. D’Amico, M. Barone, T. Tavella, D. Monti, M. Capri, A. Astolfi, P. Brigidi, E. Biagi, et al. 2020. Shotgun metagenomics of gut microbiota in humans with up to extreme longevity and the increasing role of xenobiotic degradation. MSystems 5 (2):e00124–20. doi: 10.1128/mSystems.00124-20.
  • Ribeiro, M., L. Alvarenga, L. F. M. F. Cardozo, T. R. Chermut, J. Sequeira, L. de Souza Gouveia Moreira, K. T. R. Teixeira, P. G. Shiels, P. Stenvinkel, and D. Mafra. 2021. From the distinctive smell to therapeutic effects: garlic for cardiovascular, hepatic, gut, diabetes and chronic kidney disease. Clinical Nutrition (Edinburgh, Scotland) 40 (7)Clin Nutr: :4807–19. doi: 10.1016/J.CLNU.2021.03.005.
  • Robinson, M. W., D. Mcguinness, R. Swann, S. Barclay, P. R. Mills, A. H. Patel, J. Mclauchlan, and P. G. Shiels. 2013. Non cell autonomous upregulation of CDKN2 transcription linked to progression of chronic hepatitis C disease. Aging Cell 12 (6): :1141–3. doi: 10.1111/ACEL.12125.
  • Rosas-Villegas, A., M. Sánchez-Tapia, A. Avila-Nava, V. Ramírez, A. R. Tovar, and N. Torres. 2017. Differential effect of sucrose and fructose in combination with a high fat diet on intestinal microbiota and kidney oxidative stress. Nutrients 9 (4):393. doi: 10.3390/nu9040393.
  • Saccon, T. D., R. Nagpal, H. Yadav, M. B. Cavalcante, A. D. d C. Nunes, A. Schneider, A. Gesing, B. Hughes, M. Yousefzadeh, T. Tchkonia, et al. 2021. Senolytic combination of dasatinib and quercetin alleviates intestinal senescence and inflammation and modulates the gut microbiome in aged mice. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 76 (11):1895–905. doi: 10.1093/GERONA/GLAB002.
  • Sanders, J. L., and A. B. Newman. 2013. Telomere length in epidemiology: A biomarker of aging, age-related disease, both, or neither? Epidemiologic Reviews 35 (1): :112–31. doi: 10.1093/EPIREV/MXS008.
  • Santoro, A., R. Ostan, M. Candela, E. Biagi, P. Brigidi, M. Capri, and C. Franceschi. 2018. Gut microbiota changes in the extreme decades of human life: A focus on centenarians. Cellular and Molecular Life Sciences: CMLS 75 (1):129–48. doi: 10.1007/S00018-017-2674-Y.
  • Schnorr, S. L., M. Candela, S. Rampelli, M. Centanni, C. Consolandi, G. Basaglia, S. Turroni, E. Biagi, C. Peano, M. Severgnini, et al. 2014. Gut microbiome of the hadza hunter-gatherers. Nature Communications 5 (April):3654. doi: 10.1038/NCOMMS4654.
  • Scott, K. P., S. W. Gratz, P. O. Sheridan, H. J. Flint, and S. H. Duncan. 2013. The influence of diet on the gut microbiota. Pharmacological Research 69 (1):52–60. doi: 10.1016/J.PHRS.2012.10.020.
  • Shankar, E., A. Goel, K. Gupta, and S. Gupta. 2017. Plant Flavone Apigenin: An Emerging Anticancer Agent. Current Pharmacology Reports 3 (6)Curr Pharmacol Rep: :423–46. doi: 10.1007/S40495-017-0113-2.
  • Shannon, O. M., A. W. Ashor, F. Scialo, G. Saretzki, C. Martin-Ruiz, J. Lara, J. Matu, A. Griffiths, N. Robinson, L. Lillà, et al. 2021. Mediterranean diet and the hallmarks of ageing. European Journal of Clinical Nutrition 75 (8):1176–92. doi: 10.1038/S41430-020-00841-X.
  • Shao, Z., B. Wang, Y. Shi, C. Xie, C. Huang, B. Chen, H. Zhang, G. Zeng, H. Liang, Y. Wu, et al. 2021. Senolytic agent quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-ΚB Axis. Osteoarthritis and Cartilage 29 (3):413–22. doi: 10.1016/J.JOCA.2020.11.006.
  • Shiels, P. G., S. Buchanan, C. Selman, and P. Stenvinkel. 2019. Allostatic load and ageing: Linking the microbiome and nutrition with age-related health. Biochemical Society Transactions 47 (4):1165–72. doi: 10.1042/BST20190110.
  • Shiels, P. G., D. McGuinness, M. Eriksson, J. P. Kooman, and P. Stenvinkel. 2017. The role of epigenetics in renal ageing. Nature Reviews. Nephrology 13 (8):471–82. doi: 10.1038/nrneph.2017.78.
  • Shiels, P. G., J. Painer, B. Natterson-Horowitz, R. J. Johnson, J. J. Miranda, and P. Stenvinkel. 2021. Manipulating the exposome to enable better ageing. The Biochemical Journal 478 (14):2889–98. doi: 10.1042/BCJ20200958.
  • Shiels, P., and K. Ritzau-Reid. 2015. Biological ageing, inflammation and nutrition: How might they impact on systemic sclerosis? Current Aging Science 8 (2):123–30. doi: 10.2174/187460980801150727110353.
  • Singh, S.,. A. Kumar Singh, G. Garg, and S. I. Rizvi. 2018. Fisetin as a caloric restriction mimetic protects rat brain against aging induced oxidative stress, apoptosis and neurodegeneration. Life Sciences 193 (January):171–9. doi: 10.1016/J.LFS.2017.11.004.
  • Singh, S. P., J. Singh Jadaun, L. K. Narnoliya, and A. Pandey. 2017. Prebiotic oligosaccharides: Special focus on fructooligosaccharides, its biosynthesis and bioactivity. Applied Biochemistry and Biotechnology 183 (2):613–35. doi: 10.1007/S12010-017-2605-2.
  • Solon-Biet, S. M., A. C. McMahon, J. W. O. Ballard, K. Ruohonen, L. E. Wu, V. C. Cogger, A. Warren, X. Huang, N. Pichaud, R. G. Melvin, et al. 2014. The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice. Cell Metabolism 19 (3):418–30. doi: 10.1016/J.CMET.2014.02.009.
  • Solon-Biet, S. M., S. J. Mitchell, S. C. P. Coogan, V. C. Cogger, R. Gokarn, A. C. McMahon, D. Raubenheimer, R. de Cabo, S. J. Simpson, and D. G. Le Couteur. 2015. Dietary protein to carbohydrate ratio and caloric restriction: Comparing metabolic outcomes in mice. Cell Reports 11 (10):1529–34. doi: 10.1016/J.CELREP.2015.05.007.
  • Stenvinkel, P., and P. G. Shiels. 2019. Long-lived animals with negligible senescence: Clues for ageing research. Biochemical Society Transactions 47 (4):1157–64. doi: 10.1042/BST20190105.
  • Sun, C., W. Jin, and H. Shi. 2017. Oligomeric proanthocyanidins protects A549 cells against H2O2-induced oxidative stress via the Nrf2-ARE pathway. International Journal of Molecular Medicine 39 (6):1548–54. doi: 10.3892/IJMM.2017.2971.
  • Takiishi, T., C. I. M. Fenero, and N. O. S. Câmara. 2017. Intestinal barrier and gut microbiota: Shaping our immune responses throughout life. Tissue Barriers 5 (4):e1373208. doi: 10.1080/21688370.2017.1373208.
  • Thevaranjan, N., A. Puchta, C. Schulz, A. Naidoo, J. C. Szamosi, C. P. Verschoor, D. Loukov, L. P. Schenck, J. Jury, K. P. Foley, et al. 2017. Age-associated microbial dysbiosis promotes intestinal permeability, systemic inflammation, and macrophage dysfunction. Cell Host & Microbe 21 (4):455–66.e4. doi: 10.1016/J.CHOM.2017.03.002.
  • Tuikhar, N., S. Keisam, R. K. Labala, P. Ramakrishnan, M. C. Arunkumar, G. Ahmed, E. Biagi, and K. Jeyaram. 2019. Comparative analysis of the gut microbiota in centenarians and young adults shows a common signature across genotypically non-related populations. Mechanisms of Ageing and Development 179 (April):23–35. doi: 10.1016/J.MAD.2019.02.001.
  • Umemoto, S., U. Onaka, R. Kawano, A. Kawamura, S. Motoi, N. Honda, H. Kanazashi, and M. Mitarai. 2022. Effects of a Japanese cuisine-based antihypertensive diet and fish oil on blood pressure and its variability in participants with untreated normal high blood pressure or stage I hypertension: A feasibility randomized controlled study. Journal of Atherosclerosis and Thrombosis 29 (2):152–73. doi: 10.5551/JAT.57802.
  • Ungvari, Z., S. Tarantini, Á. Nyúl-Tóth, T. Kiss, A. Yabluchanskiy, T. Csipo, P. Balasubramanian, A. Lipecz, Z. Benyo, and A. Csiszar. 2019. Nrf2 dysfunction and impaired cellular resilience to oxidative stressors in the aged vasculature: From increased cellular senescence to the pathogenesis of age-related vascular diseases. GeroScience 41 (6):727–38. doi: 10.1007/S11357-019-00107-W.
  • Vaiserman, A., and D. Krasnienkov. 2020. Telomere length as a marker of biological age: State-of-the-art, open issues, and future perspectives. Frontiers in Genetics 11 (January):630186. doi: 10.3389/FGENE.2020.630186.
  • Vázquez-Medina, J. P., J. G. Sonanez-Organis, R. Rodriguez, J. A. Viscarra, A. Nishiyama, D. E. Crocker, and R. M. Ortiz. 2013. Prolonged fasting activates Nrf2 in post-weaned elephant seals. The Journal of Experimental Biology 216 (Pt 15):2870–8. doi: 10.1242/JEB.081927.
  • Vemuri, R., R. Gundamaraju, M. D. Shastri, S. D. Shukla, K. Kalpurath, M. Ball, S. Tristram, E. M. Shankar, K. Ahuja, and R. Eri. 2018. Gut microbial changes, interactions, and their implications on human lifecycle: An ageing perspective. BioMed Research International 2018Biomed Res Int: :4178607. doi: 10.1155/2018/4178607.
  • Wan, Y., F. Wang, J. Yuan, J. Li, D. Jiang, J. Zhang, H. Li, R. Wang, J. Tang, T. Huang, et al. 2019. Effects of dietary fat on gut microbiota and faecal metabolites, and their relationship with cardiometabolic risk factors: A 6-month randomised controlled-feeding trial. Gut 68 (8):1417–29. doi: 10.1136/gutjnl-2018-317609.
  • Wang, A., J. Wei, C. Lu, H. Chen, X. Zhong, Y. Lu, L. Li, H. Huang, Z. Dai, and L. Han. 2019. Genistein suppresses psoriasis-related inflammation through a STAT3-NF-ΚB-dependent mechanism in keratinocytes. International Immunopharmacology 69 (April):270–8. doi: 10.1016/J.INTIMP.2019.01.054.
  • Wang, F., T. Yu, G. Huang, D. Cai, X. Liang, H. Su, Z. Zhu, D. Li, Y. Yang, P. Shen, et al. 2015. Gut Microbiota community and its assembly associated with age and diet in chinese centenarians. Journal of Microbiology and Biotechnology 25 (8):1195–204. doi: 10.4014/JMB.1410.10014.
  • Wang, P., Y. Yang, D. Wang, Q. Yang, J. Wan, S. Liu, P. Zhou, and Y. Yang. 2020. Cinnamaldehyde ameliorates vascular dysfunction in diabetic mice by activating Nrf2. American Journal of Hypertension 33 (7):610–9. doi: 10.1093/AJH/HPAA024.
  • Waterland, R. A., and R. L. Jirtle. 2003. Transposable elements: Targets for early nutritional effects on epigenetic gene regulation. Molecular and Cellular Biology 23 (15):5293–300. doi: 10.1128/MCB.23.15.5293-5300.2003.
  • Weyh, C., K. Krüger, and B. Strasser. 2020. Physical activity and diet shape the immune system during aging. Nutrients 12 (3):622. doi: 10.3390/nu12030622.
  • Wiley, C. D., J. M. Flynn, C. Morrissey, R. Lebofsky, J. Shuga, X. Dong, M. A. Unger, J. Vijg, S. Melov, and J. Campisi. 2017. Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence. Aging Cell 16 (5):1043–50. doi: 10.1111/ACEL.12632.
  • Willett, W.,. J. Rockström, B. Loken, M. Springmann, T. Lang, S. Vermeulen, T. Garnett, D. Tilman, F. DeClerck, A. Wood, et al. 2019. Food in the anthropocene: The EAT-lancet commission on healthy diets from sustainable food systems. The Lancet 393 (10170):447–92. doi: 10.1016/S0140-6736(18)31788-4.
  • Williamson, G., and A. Kerimi. 2020. Testing of natural products in clinical trials targeting the SARS-CoV-2 (Covid-19) viral spike protein-angiotensin converting enzyme-2 (ACE2) interaction. Biochemical Pharmacology 178 (August):114123. doi: 10.1016/J.BCP.2020.114123.
  • Wisniewski, P. J., R. A. Dowden, and S. C. Campbell. 2019. Role of dietary lipids in modulating inflammation through the gut microbiota. Nutrients 11 (1):117. doi: 10.3390/nu11010117.
  • Wu, G. D., J. Chen, C. Hoffmann, K. Bittinger, Y.-Y. Chen, S. A. Keilbaugh, M. Bewtra, D. Knights, W. A. Walters, R. Knight, et al. 2011. Linking long-term dietary patterns with gut microbial enterotypes. Science (New York, N.Y.) 334 (6052):105–8. doi: 10.1126/SCIENCE.1208344.
  • Yang, L., D. Xian, X. Xiong, R. Lai, J. Song, and J. Zhong. 2018. Proanthocyanidins against oxidative stress: From molecular mechanisms to clinical applications. BioMed Research International 2018:8584136. doi: 10.1155/2018/8584136.
  • Yousefzadeh, M. J., Y. Zhu, S. J. McGowan, L. Angelini, H. Fuhrmann-Stroissnigg, M. Xu, Y. Y. Ling, K. I. Melos, T. Pirtskhalava, C. L. Inman, et al. 2018. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine 36 (October):18–28. doi: 10.1016/J.EBIOM.2018.09.015.
  • Yu, Y.,. K. Paul, O. A. Arah, E. R. Mayeda, J. Wu, E. Lee, I.-F. Shih, J. Su, M. Jerrett, M. Haan, et al. 2020. Air pollution, noise exposure, and metabolic syndrome – A cohort study in elderly Mexican-Americans in sacramento area. Environment International 134 (January):105269. doi: 10.1016/j.envint.2019.105269.
  • Zhang, H., W. Zheng, X. Feng, F. Yang, H. Qin, S. Wu, D. X. Hou, and J. Chen. 2019. Nrf2-ARE signaling acts as master pathway for the cellular antioxidant activity of fisetin. Molecules 24 (4):708. doi: 10.3390/molecules24040708.
  • Zhang, J., X. Zhao, H. Zhu, J. Wang, J. Ma, and M. Gu. 2019. Apigenin protects against renal tubular epithelial cell injury and oxidative stress by high glucose via regulation of NF-E2-related factor 2 (Nrf2) pathway. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research 25:5280–8. doi: 10.12659/MSM.915038.
  • Zhao, L., and C. Zhang. 2020. Berberine inhibits MDA-MB-231 cells by attenuating their inflammatory responses. BioMed Research International 2020:3617514. doi: 10.1155/2020/3617514.
  • Zhu, D., G. Xu, S. Ghandhi, and K. Hubbard. 2002. Modulation of the expression of P16INK4a and P14ARF by HnRNP A1 and A2 RNA binding proteins: Implications for cellular senescence. Journal of Cellular Physiology 193 (1):19–25. doi: 10.1002/JCP.10147.
  • Zhu, W., J. C. Gregory, E. Org, J. A. Buffa, N. Gupta, Z. Wang, L. Li, X. Fu, Y. Wu, M. Mehrabian, et al. 2016. Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk. Cell 165 (1):111–24. doi: 10.1016/J.CELL.2016.02.011.
  • Zhu, Y., E. J. Doornebal, T. Pirtskhalava, N. Giorgadze, M. Wentworth, H. Fuhrmann-Stroissnigg, L. J. Niedernhofer, P. D. Robbins, T. Tchkonia, and J. L. Kirkland. 2017. New agents that target senescent cells: The flavone, fisetin, and the BCL-X L inhibitors, A1331852 and A1155463. Aging 9 (3):955–63. doi: 10.18632/AGING.101202.
  • Ziegler, D. V., C. D. Wiley, and M. C. Velarde. 2015. Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging. Aging Cell 14 (1):1–7. doi: 10.1111/ACEL.12287.

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