The road ahead of dietary restriction on anti-aging: focusing on personalized nutrition

References

• Acosta-Rodríguez, V., F. Rijo-Ferreira, M. Izumo, P. Xu, M. Wight-Carter, C. B. Green, and J. S. Takahashi. 2022. Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice. Science 376 (6598):1192–202. doi: 10.1126/science.abk0297.
   PubMed Web of Science ®Google Scholar
• Ahadi, S., W. Zhou, S. M. Schüssler-Fiorenza Rose, M. R. Sailani, K. Contrepois, M. Avina, M. Ashland, A. Brunet, and M. Snyder. 2020. Personal aging markers and ageotypes revealed by deep longitudinal profiling. Nature Medicine 26 (1):83–90. doi: 10.1038/s41591-019-0719-5.
   PubMed Web of Science ®Google Scholar
• Antosh, M., R. Whitaker, A. Kroll, S. Hosier, C. Chang, J. Bauer, L. Cooper, N. Neretti, and S. L. Helfand. 2011. Comparative transcriptional pathway bioinformatic analysis of dietary restriction, Sir2, p53 and resveratrol life span extension in Drosophila. Cell Cycle (Georgetown, Tex.) 10 (6):904–11. doi: 10.4161/cc.10.6.14912.
   PubMed Web of Science ®Google Scholar
• Asadi Shahmirzadi, A., D. Edgar, C. Y. Liao, Y. M. Hsu, M. Lucanic, A. Asadi Shahmirzadi, C. D. Wiley, G. Gan, D. E. Kim, H. G. Kasler, et al. 2020. Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice. Cell Metabolism 32 (3):447–456 e6. doi: 10.1016/j.cmet.2020.08.004.
   PubMed Web of Science ®Google Scholar
• Asher, G., and P. Sassone-Corsi. 2015. Time for food: The intimate interplay between nutrition, metabolism, and the circadian clock. Cell 161 (1):84–92. doi: 10.1016/j.cell.2015.03.015.
   PubMed Web of Science ®Google Scholar
• Auwerx, C., and J. Cantó. 2011. Calorie restriction: Is AMPK a key sensor and effector? Physiology (Bethesda, Md.) 26 (4):214–24. doi: 10.1152/physiol.00010.2011.
   PubMed Web of Science ®Google Scholar
• Barrett, E. L. B., and D. S. Richardson. 2011. Sex differences in telomeres and lifespan. Aging Cell 10 (6):913–21. doi: 10.1111/j.1474-9726.2011.00741.x.
   PubMed Web of Science ®Google Scholar
• Barrington, W. T., P. Wulfridge, A. E. Wells, C. M. Rojas, S. Y. F. Howe, A. Perry, K. Hua, M. A. Pellizzon, K. D. Hansen, B. H. Voy, et al. 2018. Improving metabolic health through precision dietetics in mice. Genetics 208 (1):399–417. doi: 10.1534/genetics.117.300536.
   PubMed Web of Science ®Google Scholar
• Barzilai, N., D. M. Huffman, R. H. Muzumdar, and A. Bartke. 2012. The critical role of metabolic pathways in aging. Diabetes 61 (6):1315–22. doi: 10.2337/db11-1300.
   PubMed Web of Science ®Google Scholar
• Berry, S. E., A. M. Valdes, D. A. Drew, F. Asnicar, M. Mazidi, J. Wolf, J. Capdevila, G. Hadjigeorgiou, R. Davies, H. Al Khatib, et al. 2020. Human postprandial responses to food and potential for precision nutrition. Nature Medicine 26 (6):964–73. doi: 10.1038/s41591-020-0934-0.
   PubMed Web of Science ®Google Scholar
• Bjedov, I., H. M. Cocheme, A. Foley, D. Wieser, N. S. Woodling, J. I. Castillo-Quan, P. Norvaisas, C. Lujan, J. C. Regan, J. M. Toivonen, et al. 2020. Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila. PLoS Genetics 16 (11):e1009083. doi: 10.1371/journal.pgen.1009083.
   PubMed Web of Science ®Google Scholar
• Brandhorst, S., I. Y. Choi, M. Wei, C. W. Cheng, S. Sedrakyan, G. Navarrete, L. Dubeau, L. P. Yap, R. Park, M. Vinciguerra, et al. 2015. A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance, and healthspan. Cell Metabolism 22 (1):86–99. doi: 10.1016/j.cmet.2015.05.012.
   PubMed Web of Science ®Google Scholar
• Carpenter, D., S. Dhar, L. M. Mitchell, B. Fu, J. Tyson, N. A. Shwan, F. Yang, M. G. Thomas, and J. A. Armour. 2015. Obesity, starch digestion and amylase: Association between copy number variants at human salivary (AMY1) and pancreatic (AMY2) amylase genes. Human Molecular Genetics 24 (12):3472–80. doi: 10.1093/hmg/ddv098.
   PubMed Web of Science ®Google Scholar
• Carter, S., P. M. Clifton, and J. B. Keogh. 2018. Effect of intermittent compared with continuous energy restricted diet on glycemic control in patients with type 2 diabetes: A randomized noninferiority trial. JAMA Network Open 1 (3):e180756. doi: 10.1001/jamanetworkopen.2018.0756.
   PubMed Web of Science ®Google Scholar
• Catterson, J. H., M. Khericha, M. C. Dyson, A. J. Vincent, R. Callard, S. M. Haveron, A. Rajasingam, M. Ahmad, and L. Partridge. 2018. Short-term, intermittent fasting induces long-lasting gut health and TOR-independent lifespan extension. Current Biology : CB 28 (11):1714–24.e4. doi: 10.1016/j.cub.2018.04.015.
   PubMed Web of Science ®Google Scholar
• Chaix, A., A. Zarrinpar, P. Miu, and S. Panda. 2014. Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges. Cell Metabolism 20 (6):991–1005. doi: 10.1016/j.cmet.2014.11.001.
   PubMed Web of Science ®Google Scholar
• Chaix, A., E. N. C. Manoogian, G. C. Melkani, and S. Panda. 2019. Time-restricted eating to prevent and manage chronic metabolic diseases. Annual Review of Nutrition 39:291–315. doi: 10.1146/annurev-nutr-082018-124320.
   PubMed Web of Science ®Google Scholar
• Chassard, C., and C. Lacroix. 2013. Carbohydrates and the human gut microbiota. Current Opinion in Clinical Nutrition and Metabolic Care 16 (4):453–60. doi: 10.1097/MCO.0b013e3283619e63.
   PubMed Web of Science ®Google Scholar
• Chen, L., D. Wang, S. Garmaeva, A. Kurilshikov, A. Vich Vila, R. Gacesa, T. Sinha, E. Segal, R. K. Weersma, C. Wijmenga, et al. 2021. The long-term genetic stability and individual specificity of the human gut microbiome. Cell 184 (9):2302–2315 e12. doi: 10.1016/j.cell.2021.03.024.
   PubMed Web of Science ®Google Scholar
• Chen, Y., H. Wang, W. Lu, T. Wu, W. Yuan, J. Zhu, Y. K. Lee, J. Zhao, H. Zhang, and W. Chen. 2022. Human gut microbiome aging clocks based on taxonomic and functional signatures through multi-view learning. Gut Microbes 14 (1):2025016. doi: 10.1080/19490976.2021.2025016.
   PubMed Web of Science ®Google Scholar
• Chin, R. M., X. Fu, M. Y. Pai, L. Vergnes, H. Hwang, G. Deng, S. Diep, B. Lomenick, V. S. Meli, G. C. Monsalve, et al. 2014. The metabolite alpha-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature 510 (7505):397–401. doi: 10.1038/nature13264.
   PubMed Web of Science ®Google Scholar
• Clutton-Brock, T. H., and K. Isvaran. 2007. Sex differences in ageing in natural populations of vertebrates. Proc Biol Sci. 274 (1629):3097–104. doi: 10.1098/rspb.2007.1138.
   PubMed Web of Science ®Google Scholar
• Colman, R. J., R. M. Anderson, S. C. Johnson, E. K. Kastman, K. J. Kosmatka, T. M. Beasley, D. B. Allison, C. Cruzen, H. A. Simmons, J. W. Kemnitz, et al. 2009. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 325 (5937):201–4. doi: 10.1126/science.1173635.
   PubMed Web of Science ®Google Scholar
• Corella, D., G. Peloso, D. K. Arnett, S. Demissie, L. A. Cupples, K. Tucker, C.-Q. Lai, L. D. Parnell, O. Coltell, Y.-C. Lee, et al. 2009. APOA2, dietary fat, and body mass index: Replication of a gene-diet interaction in 3 independent populations. Archives of Internal Medicine 169 (20):1897–906. doi: 10.1001/archinternmed.2009.343.
   PubMedGoogle Scholar
• Crosby, L., B. Davis, S. Joshi, M. Jardine, J. Paul, M. Neola, and N. D. Barnard. 2021. Ketogenic diets and chronic disease: Weighing the benefits against the risks. Frontiers in Nutrition 8:702802.
   PubMed Web of Science ®Google Scholar
• Cuervo, A. M. 2008. Autophagy and aging: Keeping that old broom working. Trends in Genetics 24 (12):604–12. doi: 10.1016/j.tig.2008.10.002.
   PubMed Web of Science ®Google Scholar
• De Marte, M. L., and H. E. Enesco. 1986. Influence of low tryptophan diet on survival and organ growth in mice. Mechanisms of Ageing and Development 36 (2):161–71. doi: 10.1016/0047-6374(86)90017-5.
   PubMed Web of Science ®Google Scholar
• Dehghan, M., A. Mente, X. Zhang, S. Swaminathan, W. Li, V. Mohan, R. Iqbal, R. Kumar, E. Wentzel-Viljoen, A. Rosengren, et al. 2017. Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): A prospective cohort study. The Lancet 390 (10107):2050–62. doi: 10.1016/S0140-6736(17)32252-3.
   Google Scholar
• Demidenko, O., D. Barardo, V. Budovskii, R. Finnemore, F. R. Palmer, B. K. Kennedy, and Y. V. Budovskaya. 2021. Rejuvant(R), a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test. Aging 13 (22):24485–99. doi: 10.18632/aging.203736.
   PubMedGoogle Scholar
• Di Francesco, A., C. Di Germanio, M. Bernier, and R. de Cabo. 2018. A time to fast. Science 362 (6416):770–5. doi: 10.1126/science.aau2095.
   PubMed Web of Science ®Google Scholar
• Douris, N., T. Melman, J. M. Pecherer, P. Pissios, J. S. Flier, L. C. Cantley, J. W. Locasale, and E. Maratos-Flier. 2015. Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet. Biochimica et Biophysica Acta 1852 (10 Pt A):2056–65. doi: 10.1016/j.bbadis.2015.07.009.
   PubMed Web of Science ®Google Scholar
• Eisenberg, T., H. Knauer, A. Schauer, S. Büttner, C. Ruckenstuhl, D. Carmona-Gutierrez, J. Ring, S. Schroeder, C. Magnes, L. Antonacci, et al. 2009. Induction of autophagy by spermidine promotes longevity. Nature Cell Biology 11 (11):1305–14. doi: 10.1038/ncb1975.
   PubMed Web of Science ®Google Scholar
• Elliott, M. L., A. Caspi, R. M. Houts, A. Ambler, J. M. Broadbent, R. J. Hancox, H. Harrington, S. Hogan, R. Keenan, A. Knodt, et al. 2021. Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy. Nature Aging 1 (3):295–308. doi: 10.1038/s43587-021-00044-4.
   PubMedGoogle Scholar
• Estruch, R., E. Ros, J. Salas-Salvado, M. I. Covas, D. Corella, F. Aros, E. Gomez-Gracia, V. Ruiz-Gutierrez, M. Fiol, J. Lapetra, et al. 2018. Primary prevention of cardiovascular disease with a mediterranean diet supplemented with extra-virgin olive oil or nuts. The New England Journal of Medicine 378 (25):e34. doi: 10.1056/NEJMoa1800389.
   PubMed Web of Science ®Google Scholar
• Fatahi, S., A. Nazary-Vannani, M. H. Sohouli, Z. Mokhtari, H. Kord-Varkaneh, V. Moodi, S. C. Tan, T. Y. Low, F. Zanghelini, and F. Shidfar. 2021. The effect of fasting and energy restricting diets on markers of glucose and insulin controls: A systematic review and meta-analysis of randomized controlled trials. Critical Reviews in Food Science and Nutrition 61 (20):3383–94. doi: 10.1080/10408398.2020.1798350.
   PubMed Web of Science ®Google Scholar
• Fernandes, G., E. J. Yunis, and R. A. Good. 1976. Influence of diet on survival of mice. Proceedings of the National Academy of Sciences of the United States of America 73 (4):1279–83. doi: 10.1073/pnas.73.4.1279.
   PubMed Web of Science ®Google Scholar
• Flanagan, E. W., J. Most, J. T. Mey, and L. M. Redman. 2020. Calorie restriction and aging in humans. Annual Review of Nutrition 40:105–33. doi: 10.1146/annurev-nutr-122319-034601.
   PubMed Web of Science ®Google Scholar
• Fontana, L., and L. Partridge. 2015. Promoting health and longevity through diet: from model organisms to humans. Cell 161 (1):106–18. doi: 10.1016/j.cell.2015.02.020.
   PubMed Web of Science ®Google Scholar
• Fontana, L., L. Partridge, and V. D. Longo. 2010. Extending healthy life span-from yeast to humans. Science (New York, N.Y.) 328 (5976):321–6. doi: 10.1126/science.1172539.
   PubMed Web of Science ®Google Scholar
• Forster, M. J., P. Morris, and R. S. Sohal. 2003. Genotype and age influence the effect of caloric intake on mortality in mice. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology 17 (6):690–2. doi: 10.1096/fj.02-0533fje.
   PubMedGoogle Scholar
• Fraumene, C., V. Manghina, E. Cadoni, F. Marongiu, M. Abbondio, M. Serra, A. Palomba, A. Tanca, E. Laconi, and S. Uzzau. 2018. Caloric restriction promotes rapid expansion and long-lasting increase of Lactobacillus in the rat fecal microbiota. Gut Microbes 9 (2):104–14. doi: 10.1080/19490976.2017.1371894.
   PubMed Web of Science ®Google Scholar
• Fung, T. T., R. M. van Dam, S. E. Hankinson, M. Stampfer, W. C. Willett, and F. B. Hu. 2010. Low-carbohydrate diets and all-cause and cause-specific mortality: Two cohort studies. Annals of Internal Medicine 153 (5):289–98. doi: 10.7326/0003-4819-153-5-201009070-00003.
   PubMed Web of Science ®Google Scholar
• Galkin, F., A. Aliper, E. Putin, I. Kuznetsov, V. N. Gladyshev, and A. Zhavoronkov. 2018. Human Gut Microbiome Aging Clock Based on Taxonomic Profiling and Deep Learning. iScience 23 (6):101199. doi: 10.1101/507780.
   Web of Science ®Google Scholar
• Galkin, F., P. Mamoshina, A. Aliper, E. Putin, V. Moskalev, V. N. Gladyshev, and A. Zhavoronkov. 2020. Human gut microbiome aging clock based on taxonomic profiling and deep learning. iScience 23 (6):101199. doi: 10.1016/j.isci.2020.101199.
   PubMed Web of Science ®Google Scholar
• Galkin, F., P. Mamoshina, A. Aliper, J. P. de Magalhaes, V. N. Gladyshev, and A. Zhavoronkov. 2020. Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities. Ageing Research Reviews 60:101050. doi: 10.1016/j.arr.2020.101050.
   PubMed Web of Science ®Google Scholar
• Galkin, F., P. Mamoshina, K. Kochetov, D. Sidorenko, and A. Zhavoronkov. 2021. DeepMAge: A methylation aging clock developed with deep learning. Aging and Disease 12 (5):1252–62. doi: 10.14336/AD.2020.1202.
   PubMed Web of Science ®Google Scholar
• Gan, J., J. B. Siegel, and J. B. German. 2019. Molecular annotation of food - Towards personalized diet and precision health. Trends in Food Science & Technology 91:675–80. doi: 10.1016/j.tifs.2019.07.016.
   PubMed Web of Science ®Google Scholar
• Gelino, S., J. T. Chang, C. Kumsta, X. She, A. Davis, C. Nguyen, S. Panowski, and M. Hansen. 2016. Intestinal autophagy improves healthspan and longevity in C. elegans during dietary restriction. PLOS Genetics 12 (7):e1006135. doi: 10.1371/journal.pgen.1006135.
   PubMed Web of Science ®Google Scholar
• Ghosh, T. S., F. Shanahan, and P. W. O’Toole. 2022. The gut microbiome as a modulator of healthy ageing. Nature Reviews Gastroenterology & Hepatology doi: 10.1038/s41575-022-00605-x.
   PubMed Web of Science ®Google Scholar
• Gill, S., H. D. Le, G. C. Melkani, and S. Panda. 2015. Time-restricted feeding attenuates age-related cardiac decline in Drosophila. Science (New York, N.Y.) 347 (6227):1265–9. doi: 10.1126/science.1256682.
   PubMed Web of Science ®Google Scholar
• Goodrick, C. L., D. K. Ingram, M. A. Reynolds, J. R. Freeman, and N. L. Cider. 1982. Effects of intermittent feeding upon growth and life span in rats. Gerontology 28 (4):233–41. doi: 10.1159/000212538.
   PubMed Web of Science ®Google Scholar
• Guarente, L. 2007. Sirtuins in aging and disease. Cold Spring Harbor Symposia on Quantitative Biology 72:483–8. doi: 10.1101/sqb.2007.72.024.
   PubMedGoogle Scholar
• Gutiérrez‐Repiso, C., C. Hernández‐García, Jos. éM. García‐Almeida, D. Bellido, G M. ía Martín‐Núñez, L. Sánchez‐Alcoholado, J. Alcaide‐Torres, I. Sajoux, F. J. Tinahones, and I. Moreno‐Indias. 2019. Effect of synbiotic supplementation in a very-low-calorie ketogenic diet on weight loss achievement and gut microbiota: A randomized controlled pilot study. Molecular Nutrition & Food Research 63 (19):1900167. doi: 10.1002/mnfr.201900167.
   PubMed Web of Science ®Google Scholar
• Gyanwali, B., Z. X. Lim, J. Soh, C. Lim, S. P. Guan, J. Goh, A. B. Maier, and B. K. Kennedy. 2022. Alpha-Ketoglutarate dietary supplementation to improve health in humans. Trends in Endocrinology and Metabolism: TEM 33 (2):136–46. doi: 10.1016/j.tem.2021.11.003.
   PubMed Web of Science ®Google Scholar
• Hahn, O., L. F. Drews, A. Nguyen, T. Tatsuta, L. Gkioni, O. Hendrich, Q. Zhang, T. Langer, S. Pletcher, M. J. O. Wakelam, et al. 2019. A nutritional memory effect counteracts benefits of dietary restriction in old mice. Nature Metabolism 1 (11):1059–73. doi: 10.1038/s42255-019-0121-0.
   PubMedGoogle Scholar
• Hannum, G., J. Guinney, L. Zhao, L. Zhang, G. Hughes, S. Sadda, B. Klotzle, M. Bibikova, J. B. Fan, Y. Gao, et al. 2013. Genome-wide methylation profiles reveal quantitative views of human aging rates. Molecular Cell 49 (2):359–67. doi: 10.1016/j.molcel.2012.10.016.
   PubMed Web of Science ®Google Scholar
• Harvie, M. N., and T. Howell. 2016. Could intermittent energy restriction and intermittent fasting reduce rates of cancer in obese, overweight, and normal-weight subjects? A summary of evidence. Advances in Nutrition (Bethesda, Md.) 7 (4):690–705. doi: 10.3945/an.115.011767.
   PubMed Web of Science ®Google Scholar
• Hatori, M., C. Vollmers, A. Zarrinpar, L. DiTacchio, E. A. Bushong, S. Gill, M. Leblanc, A. Chaix, M. Joens, J. A. J. Fitzpatrick, et al. 2012. Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Cell Metabolism 15 (6):848–60. doi: 10.1016/j.cmet.2012.04.019.
   PubMed Web of Science ®Google Scholar
• Holmes, A. J., Y. V. Chew, F. Colakoglu, J. B. Cliff, E. Klaassens, M. N. Read, S. M. Solon-Biet, A. C. McMahon, V. C. Cogger, K. Ruohonen, et al. 2017. Diet-microbiome interactions in health are controlled by intestinal nitrogen source constraints. Cell Metabolism 25 (1):140–51. doi: 10.1016/j.cmet.2016.10.021.
   PubMed Web of Science ®Google Scholar
• Huang, J. Q., L. M. Liao, S. J. Weinstein, R. Sinha, B. I. Graubard, and D. Albanes. 2020. Association between plant and animal protein intake and overall and cause-specific mortality. JAMA Internal Medicine 180 (9):1173–84. doi: 10.1001/jamainternmed.2020.2790.
   PubMed Web of Science ®Google Scholar
• Ingram, D. K., and R. de Cabo. 2017. Calorie restriction in rodents: Caveats to consider. Ageing Research Reviews 39:15–28. doi: 10.1016/j.arr.2017.05.008.
   PubMed Web of Science ®Google Scholar
• Jordan, S., N. Tung, M. Casanova-Acebes, C. Chang, C. Cantoni, D. Zhang, T. H. Wirtz, S. Naik, S. A. Rose, C. N. Brocker, et al. 2019. Dietary intake regulates the circulating inflammatory monocyte pool. Cell 178 (5):1102–14 e17. doi: 10.1016/j.cell.2019.07.050.
   PubMed Web of Science ®Google Scholar
• Joyce, S. A., J. MacSharry, P. G. Casey, M. Kinsella, E. F. Murphy, F. Shanahan, C. Hill, and C. G. Gahan. 2014. Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut. Proceedings of the National Academy of Sciences 111 (20):7421–6. doi: 10.1073/pnas.1323599111.
   PubMed Web of Science ®Google Scholar
• Kelsey, G., K. K. Hoddy, H. Nicole, J. Song, C. M. Kroeger, J. F. Trepanowski, P. Satchidananda, and K. A. Varady. 2018. Effects of 8-hour time restricted feeding on body weight and metabolic disease risk factors in obese adults: A pilot study. Nutrition and Healthy Aging 4 (4):345–53. doi: 10.3233/NHA-170036.
   PubMedGoogle Scholar
• Kolodziejczyk, A. A., D. Zheng, and E. Elinav. 2019. Diet-microbiota interactions and personalized nutrition. Nature Reviews. Microbiology 17 (12):742–53. doi: 10.1038/s41579-019-0256-8.
   PubMed Web of Science ®Google Scholar
• Kroemer, G., C. Lopez-Otin, F. Madeo, and R. de Cabo. 2018. Carbotoxicity-noxious effects of carbohydrates. Cell 175 (3):605–14. doi: 10.1016/j.cell.2018.07.044.
   PubMed Web of Science ®Google Scholar
• Kuehbacher, T., A. Rehman, P. Lepage, S. Hellmig, U. R. Folsch, S. Schreiber, and S. J. Ott. 2008. Intestinal TM7 bacterial phylogenies in active inflammatory bowel disease. Journal of Medical Microbiology 57 (Pt 12):1569–76. doi: 10.1099/jmm.0.47719-0.
   PubMed Web of Science ®Google Scholar
• Larson, K. R., K. A. Russo, Y. Fang, N. Mohajerani, M. L. Goodson, and K. K. Ryan. 2017. Sex differences in the hormonal and metabolic response to dietary protein dilution. Endocrinology 158 (10):3477–87. doi: 10.1210/en.2017-00331.
   PubMed Web of Science ®Google Scholar
• Le Couteur, D. G., S. Solon-Biet, D. Wahl, V. C. Cogger, B. J. Willcox, D. C. Willcox, D. Raubenheimer, and S. J. Simpson. 2016. New horizons: Dietary protein, ageing and the Okinawan ratio. Age and Ageing 45 (4):443–7. doi: 10.1093/ageing/afw069.
   PubMed Web of Science ®Google Scholar
• Leeman, D. S., K. Hebestreit, T. Ruetz, A. E. Webb, A. McKay, E. A. Pollina, B. W. Dulken, X. Zhao, R. W. Yeo, T. T. Ho, et al. 2018. Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging. Science (New York, N.Y.) 359 (6381):1277–83. doi: 10.1126/science.aag3048.
   PubMed Web of Science ®Google Scholar
• Li, G., C. Xie, S. Lu, R. G. Nichols, Y. Tian, L. Li, D. Patel, Y. Ma, C. N. Brocker, T. Yan, et al. 2017. Intermittent fasting promotes white adipose browning and decreases obesity by shaping the gut microbiota. Cell Metabolism 26 (4):672–685 e4. doi: 10.1016/j.cmet.2017.08.019.
   PubMed Web of Science ®Google Scholar
• Liao, C. Y., B. A. Rikke, T. E. Johnson, J. A. L. Gelfond, V. Diaz, and J. F. Nelson. 2011. Fat maintenance is a predictor of the murine lifespan response to dietary restriction. Aging Cell 10 (4):629–39. doi: 10.1111/j.1474-9726.2011.00702.x.
   PubMed Web of Science ®Google Scholar
• Liao, C. Y., B. A. Rikke, T. E. Johnson, V. Diaz, and J. F. Nelson. 2010. Genetic variation in the murine lifespan response to dietary restriction: From life extension to life shortening. Aging Cell 9 (1):92–5. doi: 10.1111/j.1474-9726.2009.00533.x.
   PubMed Web of Science ®Google Scholar
• Lin, S. J., M. Kaeberlein, A. A. Andalis, L. A. Sturtz, P. A. Defossez, V. C. Culotta, G. R. Fink, and L. Guarente. 2002. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 418 (6895):344–8. doi: 10.1038/nature00829.
   PubMed Web of Science ®Google Scholar
• Lin, S. J., P. A. Defossez, and L. Guarente. 2000. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science (New York, N.Y.) 289 (5487):2126–8. doi:10.1126/science.289.5487.2126.
   PubMed Web of Science ®Google Scholar
• Ling, Z., X. Liu, Y. Cheng, X. Yan, and S. Wu. 2022. Gut microbiota and aging. Critical Reviews in Food Science and Nutrition 62 (13):3509–56. doi: 10.1080/10408398.2020.1867054.
   PubMed Web of Science ®Google Scholar
• Longo, V. D., and M. P. Mattson. 2014. Fasting: Molecular mechanisms and clinical applications. Cell Metabolism 19 (2):181–92. doi: 10.1016/j.cmet.2013.12.008.
   PubMed Web of Science ®Google Scholar
• Longo, V. D., and S. Panda. 2016. Fasting, circadian rhythms, and time-restricted feeding in healthy lifespan. Cell Metabolism 23 (6):1048–59. doi: 10.1016/j.cmet.2016.06.001.
   PubMed Web of Science ®Google Scholar
• Lopez-Otin, C., M. A. Blasco, L. Partridge, M. Serrano, and G. Kroemer. 2013. The hallmarks of aging. Cell 153 (6):1194–217. doi: 10.1016/j.cell.2013.05.039.
   PubMed Web of Science ®Google Scholar
• Lu, M., Y. Wan, B. Yang, C. E. Huggins, and D. Li. 2018. Effects of low-fat compared with high-fat diet on cardiometabolic indicators in people with overweight and obesity without overt metabolic disturbance: A systematic review and meta-analysis of randomised controlled trials. British Journal of Nutrition 119 (1):96–13. doi: 10.1017/S0007114517002902.
   PubMed Web of Science ®Google Scholar
• Madeo, F., D. Carmona-Gutierrez, S. J. Hofer, and G. Kroemer. 2019. Caloric restriction mimetics against age-associated disease: targets, mechanisms, and therapeutic potential. Cell Metabolism 29 (3):592–610. doi: 10.1016/j.cmet.2019.01.018.
   PubMed Web of Science ®Google Scholar
• Maegawa, S., Y. Lu, T. Tahara, J. T. Lee, J. Madzo, S. Liang, J. Jelinek, R. J. Colman, and J. J. Issa. 2017. Caloric restriction delays age-related methylation drift. Nature Communications 8 (1):539. doi: 10.1038/s41467-017-00607-3.
   PubMedGoogle Scholar
• Manoogian, E. N. C., and S. Panda. 2017. Circadian rhythms, time-restricted feeding, and healthy aging. Ageing Research Reviews 39:59–67. doi: 10.1016/j.arr.2016.12.006.
   PubMed Web of Science ®Google Scholar
• Markle, J. G., D. N. Frank, S. Mortin-Toth, C. E. Robertson, L. M. Feazel, U. Rolle-Kampczyk, M. von Bergen, K. D. McCoy, A. J. Macpherson, and J. S. Danska. 2013. Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity. Science (New York, N.Y.) 339 (6123):1084–8. doi: 10.1126/science.1233521.
   PubMed Web of Science ®Google Scholar
• Martel, J., D. M. Ojcius, Y.-F. Ko, P.-Y. Ke, C.-Y. Wu, H.-H. Peng, and J. D. Young. 2019. Hormetic Effects of phytochemicals on health and longevity. Trends in Endocrinology and Metabolism: TEM 30 (6):335–46. doi: 10.1016/j.tem.2019.04.001.
   PubMed Web of Science ®Google Scholar
• Martin, C. K., M. Bhapkar, A. G. Pittas, C. F. Pieper, S. K. Das, D. A. Williamson, T. Scott, L. M. Redman, R. Stein, C. H. Gilhooly, et al. 2016. Effect of calorie restriction on mood, quality of life, sleep, and sexual function in healthy nonobese adults: The CALERIE 2 randomized clinical trial. JAMA Internal Medicine 176 (6):743–52. doi: 10.1001/jamainternmed.2016.1189.
   PubMed Web of Science ®Google Scholar
• Martinez-Lopez, N., E. Tarabra, M. Toledo, M. Garcia-Macia, S. Sahu, L. Coletto, A. Batista-Gonzalez, N. Barzilai, J. E. Pessin, G. J. Schwartz, et al. 2017. System-wide benefits of intermeal fasting by autophagy. Cell Metabolism 26 (6):856–71 e5. doi: 10.1016/j.cmet.2017.09.020.
   PubMed Web of Science ®Google Scholar
• McCay, C. M., and M. F. Crowell. 1934. Prolonging the life span. The Scientific Monthly 39:405–14.
   Google Scholar
• Mercken, E. M., S. D. Crosby, D. W. Lamming, L. JeBailey, S. Krzysik-Walker, D. T. Villareal, M. Capri, C. Franceschi, Y. Zhang, K. Becker, D. M. Sabatini, R. de Cabo, and L. Fontana. 2013. Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile. Aging Cell 12 (4):645–51. doi: 10.1111/acel.12088.
   PubMed Web of Science ®Google Scholar
• Meydani, S. N., S. K. Das, C. F. Pieper, M. R. Lewis, S. Klein, V. D. Dixit, A. K. Gupta, D. T. Villareal, M. Bhapkar, M. Huang, et al. 2016. Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: A randomized controlled trial in non-obese humans. Aging 8 (7):1416–31. doi: 10.18632/aging.100994.
   PubMedGoogle Scholar
• Milenkovic, D., F. Capel, L. Combaret, B. Comte, D. Dardevet, B. Evrard, C. Guillet, L. E. Monfoulet, A. Pinel, S. Polakof, et al. 2022. Targeting the gut to prevent and counteract metabolic disorders and pathologies during aging. Critical Reviews in Food Science and Nutrition:1–26. doi: 10.1080/10408398.2022.2089870.
   PubMed Web of Science ®Google Scholar
• Miller, R. A., G. Buehner, Y. Chang, J. M. Harper, R. Sigler, and M. Smith-Wheelock. 2005. Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell 4 (3):119–25. doi: 10.1111/j.1474-9726.2005.00152.x.
   PubMed Web of Science ®Google Scholar
• Mirzaei, H., J. A. Suarez, and V. D. Longo. 2014. Protein and amino acid restriction, aging and disease: From yeast to humans. Trends in Endocrinology and Metabolism: TEM 25 (11):558–66. doi: 10.1016/j.tem.2014.07.002.
   PubMed Web of Science ®Google Scholar
• Mirzaei, H., R. Raynes, and V. D. Longo. 2016. The conserved role of protein restriction in aging and disease. Current Opinion in Clinical Nutrition and Metabolic Care 19 (1):74–9. doi: 10.1097/MCO.0000000000000239.
   PubMed Web of Science ®Google Scholar
• Mitchell, S. J., J. Madrigal-Matute, M. Scheibye-Knudsen, E. Fang, M. Aon, J. A. Gonzalez-Reyes, S. Cortassa, S. Kaushik, M. Gonzalez-Freire, B. Patel, et al. 2016. Effects of sex, strain, and energy intake on hallmarks of aging in mice. Cell Metabolism 23 (6):1093–112. doi: 10.1016/j.cmet.2016.05.027.
   PubMed Web of Science ®Google Scholar
• Mitchell, S. J., M. Bernier, J. A. Mattison, M. A. Aon, T. A. Kaiser, R. M. Anson, Y. Ikeno, R. M. Anderson, D. K. Ingram, and R. de Cabo. 2019. Daily fasting improves health and survival in male mice independent of diet composition and calories. Cell Metabolism 29 (1):221–8.e3. +. doi: 10.1016/j.cmet.2018.08.011.
   PubMed Web of Science ®Google Scholar
• Most, J., V. Tosti, L. M. Redman, and L. Fontana. 2017. Calorie restriction in humans: An update. Ageing Research Reviews 39:36–45. doi: 10.1016/j.arr.2016.08.005.
   PubMed Web of Science ®Google Scholar
• Mueller, S., K. Saunier, C. Hanisch, E. Norin, L. Alm, T. Midtvedt, A. Cresci, S. Silvi, C. Orpianesi, M. C. Verdenelli, et al. 2006. Differences in fecal microbiota in different European study populations in relation to age, gender, and country: A cross-sectional study. Applied and Environmental Microbiology 72 (2):1027–33. doi: 10.1128/AEM.72.2.1027-1033.2006.
   PubMed Web of Science ®Google Scholar
• Muller, M., and S. Kersten. 2003. Nutrigenomics: Goals and strategies. Nature Reviews. Genetics 4 (4):315–22. doi: 10.1038/nrg1047.
   PubMed Web of Science ®Google Scholar
• Naghshi, S., and O. Sadeghi. 2021. Current evidence on dietary intakes of fatty acids and mortality. BMJ (Clinical Research ed.) 375:n2379. doi: 10.1136/bmj.n2379.
   PubMedGoogle Scholar
• Nelson, C. S., J. N. Beck, K. A. Wilson, E. R. Pilcher, P. Kapahi, and R. B. Brem. 2016. Cross-phenotype association tests uncover genes mediating nutrient response in Drosophila. BMC Genomics 17 (1):867. doi: 10.1186/s12864-016-3137-9.
   PubMedGoogle Scholar
• Newman, J. C., A. J. Covarrubias, M. Zhao, X. Yu, P. Gut, C. P. Ng, Y. Huang, S. Haldar, and E. Verdin. 2017. Ketogenic diet reduces midlife mortality and improves memory in aging mice. Cell Metabolism 26 (3):547–57 e8. doi: 10.1016/j.cmet.2017.08.004.
   PubMed Web of Science ®Google Scholar
• O’Connor, S. G., P. Boyd, C. P. Bailey, M. M. Shams-White, T. Agurs-Collins, K. Hall, J. Reedy, E. R. Sauter, and S. M. Czajkowski. 2021. Perspective: Time-restricted eating compared with caloric restriction: potential facilitators and barriers of long-term weight loss maintenance. Advances in Nutrition (Bethesda, Md.) 12 (2):325–33. doi: 10.1093/advances/nmaa168.
   PubMed Web of Science ®Google Scholar
• Oeppen, J., and J. W. Vaupel. 2002. Broken limits to life expectancy. Science (New York, N.Y.) 296 (5570):1029–31. doi: 10.1126/science.1069675.
   PubMed Web of Science ®Google Scholar
• Paivarinta, E., S. T. Itkonen, T. Pellinen, M. Lehtovirta, M. Erkkola, and A. M. Pajari. 2020. Replacing animal-based proteins with plant-based proteins changes the composition of a whole nordic diet-a randomised clinical trial in healthy Finnish adults. Nutrients 12 (4):943. doi: 10.3390/nu12040943.
   PubMed Web of Science ®Google Scholar
• Pak, H. H., S. A. Haws, C. L. Green, M. Koller, M. T. Lavarias, N. E. Richardson, S. E. Yang, S. N. Dumas, M. Sonsalla, L. Bray, et al. 2021. Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice. Nature Metabolism 3 (10):1327–41. doi: 10.1038/s42255-021-00466-9.
   PubMedGoogle Scholar
• Pan, F., L. Zhang, M. Li, Y. Hu, B. Zeng, H. Yuan, L. Zhao, and C. Zhang. 2018. Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice. Microbiome 6 (1):54. doi: 10.1186/s40168-018-0440-5.
   PubMed Web of Science ®Google Scholar
• Panda, S. 2016. Circadian physiology of metabolism. Science (New York, N.Y.) 354 (6315):1008–15. doi: 10.1126/science.aah4967.
   PubMed Web of Science ®Google Scholar
• Parkhitko, A. A., P. Jouandin, S. E. Mohr, and N. Perrimon. 2019. Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species. Aging Cell 18 (6):e13034. doi: 10.1111/acel.13034.
   PubMed Web of Science ®Google Scholar
• Partridge, L., J. Deelen, and P. E. Slagboom. 2018. Facing up to the global challenges of ageing. Nature 561 (7721):45–56. doi: 10.1038/s41586-018-0457-8.
   PubMed Web of Science ®Google Scholar
• Partridge, L., M. Fuentealba, and B. K. Kennedy. 2020. The quest to slow ageing through drug discovery. Nature Reviews. Drug Discovery 19 (8):513–32. doi: 10.1038/s41573-020-0067-7.
   PubMed Web of Science ®Google Scholar
• Patel, S. A., A. Chaudhari, R. Gupta, N. Velingkaar, and R. V. Kondratov. 2016. Circadian clocks govern calorie restriction-mediated life span extension through BMAL1-and IGF-1-dependent mechanisms. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology 30 (4):1634–42. doi: 10.1096/fj.15-282475.
   PubMed Web of Science ®Google Scholar
• Patel, S. A., N. Velingkaar, K. Makwana, A. Chaudhari, and R. Kondratov. 2016. Calorie restriction regulates circadian clock gene expression through BMAL1 dependent and independent mechanisms. Scientific Reports 6:25970. doi: 10.1038/srep25970.
   PubMed Web of Science ®Google Scholar
• Raman, M., I. Ahmed, P. M. Gillevet, C. S. Probert, N. M. Ratcliffe, S. Smith, R. Greenwood, M. Sikaroodi, V. Lam, P. Crotty, et al. 2013. Fecal microbiome and volatile organic compound metabolome in obese humans with nonalcoholic fatty liver disease. Clinical Gastroenterology and Hepatology : The Official Clinical Practice Journal of the American Gastroenterological Association 11 (7):868–75 e1-3. doi: 10.1016/j.cgh.2013.02.015.
   PubMed Web of Science ®Google Scholar
• Rangan, P., I. Choi, M. Wei, G. Navarrete, E. Guen, S. Brandhorst, N. Enyati, G. Pasia, D. Maesincee, V. Ocon, et al. 2019. Fasting-mimicking diet modulates microbiota and promotes intestinal regeneration to reduce inflammatory bowel disease pathology. Cell Reports 26 (10):2704–19 e6. doi: 10.1016/j.celrep.2019.02.019.
   PubMed Web of Science ®Google Scholar
• Rasa, S. M. M., F. Annunziata, A. Krepelova, S. Nunna, O. Omrani, N. Gebert, L. Adam, S. Kappel, S. Hohn, G. Donati, et al. 2022. Inflammaging is driven by upregulation of innate immune receptors and systemic interferon signaling and is ameliorated by dietary restriction. Cell Reports 39 (13):111017. doi: 10.1016/j.celrep.2022.111017.
   PubMed Web of Science ®Google Scholar
• Regan, J. C., and L. Partridge. 2013. Gender and longevity: Why do men die earlier than women? Comparative and experimental evidence. Best Practice & Research. Clinical Endocrinology & Metabolism 27 (4):467–79. doi: 10.1016/j.beem.2013.05.016.
   PubMed Web of Science ®Google Scholar
• Regan, J. C., M. Khericha, A. J. Dobson, E. Bolukbasi, N. Rattanavirotkul, and L. Partridge. 2016. Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction. eLife 5:e10956. doi: 10.7554/eLife.10956.
   PubMed Web of Science ®Google Scholar
• Richardson, N. E., E. N. Konon, H. S. Schuster, A. T. Mitchell, C. Boyle, A. C. Rodgers, M. Finke, L. R. Haider, D. Yu, V. Flores, et al. 2021. Lifelong restriction of dietary branched-chain amino acids has sex-specific benefits for frailty and lifespan in mice. Nature Aging 1 (1):73–86. doi: 10.1038/s43587-020-00006-2.
   PubMedGoogle Scholar
• Roberts, M. N., M. A. Wallace, A. A. Tomilov, Z. Zhou, G. R. Marcotte, D. Tran, G. Perez, E. Gutierrez-Casado, S. Koike, T. A. Knotts, et al. 2018. A ketogenic diet extends longevity and healthspan in adult mice. Cell Metabolism 27 (5):1156. doi: 10.1016/j.cmet.2018.04.005.
   PubMed Web of Science ®Google Scholar
• Rolland-Cachera, M. F., A. Briend, and K. F. Michaelsen. 2017. Dietary fat restrictions in young children and the later risk of obesity. The American Journal of Clinical Nutrition 105 (6):1566–7. doi: 10.3945/ajcn.117.152934.
   PubMed Web of Science ®Google Scholar
• Ross, M. H., E. Lustbader, and G. Bras. 1976. Dietary practices and growth responses as predictors of longevity. Nature 262 (5569):548–53. doi: 10.1038/262548a0.
   PubMed Web of Science ®Google Scholar
• Sainsbury, E., N. V. Kizirian, S. R. Partridge, T. Gill, S. Colagiuri, and A. A. Gibson. 2018. Effect of dietary carbohydrate restriction on glycemic control in adults with diabetes: A systematic review and meta-analysis. Diabetes Research and Clinical Practice 139:239–52. doi: 10.1016/j.diabres.2018.02.026.
   PubMed Web of Science ®Google Scholar
• Salas-Salvado, J., M. Bullo, R. Estruch, E. Ros, M. I. Covas, N. Ibarrola-Jurado, D. Corella, F. Aros, E. Gomez-Gracia, V. Ruiz-Gutierrez, et al. 2014. Prevention of diabetes with Mediterranean diets: A subgroup analysis of a randomized trial. Annals of Internal Medicine 160 (1):1–10. doi: 10.7326/M13-1725.
   PubMed Web of Science ®Google Scholar
• Sasikumar, A. N., D. W. Killilea, B. K. Kennedy, and R. B. Brem. 2019. Potassium restriction boosts vacuolar acidity and extends lifespan in yeast. Experimental Gerontology 120:101–6. doi: 10.1016/j.exger.2019.02.001.
   PubMed Web of Science ®Google Scholar
• Saslow, L. R., J. J. Daubenmier, J. T. Moskowitz, S. Kim, E. J. Murphy, S. D. Phinney, R. Ploutz-Snyder, V. Goldman, R. M. Cox, A. E. Mason, et al. 2017. Twelve-month outcomes of a randomized trial of a moderate-carbohydrate versus very low-carbohydrate diet in overweight adults with type 2 diabetes mellitus or prediabetes. Nutrition & Diabetes 7 (12):304. doi: 10.1038/s41387-017-0006-9.
   PubMedGoogle Scholar
• Sato, S., G. Solanas, F. O. Peixoto, L. Bee, A. Symeonidi, M. S. Schmidt, C. Brenner, S. Masri, S. A. Benitah, and P. Sassone-Corsi. 2017. Circadian reprogramming in the liver identifies metabolic pathways of aging. Cell 170 (4):664–677 e11. doi: 10.1016/j.cell.2017.07.042.
   PubMed Web of Science ®Google Scholar
• Sbierski-Kind, J., S. Grenkowitz, S. Schlickeiser, A. Sandforth, M. Friedrich, D. Kunkel, R. Glauben, S. Brachs, K. Mai, A. Thurmer, et al. 2022. Effects of caloric restriction on the gut microbiome are linked with immune senescence. Microbiome 10 (1):57. doi: 10.1186/s40168-022-01249-4.
   PubMed Web of Science ®Google Scholar
• Schaum, N., B. Lehallier, O. Hahn, R. Pálovics, S. Hosseinzadeh, S. E. Lee, R. Sit, D. P. Lee, P. M. Losada, M. E. Zardeneta, et al. 2020. Ageing hallmarks exhibit organ-specific temporal signatures. Nature 583 (7817):596–7. doi: 10.1038/s41586-020-2499-y.
   PubMed Web of Science ®Google Scholar
• Schübel, R., J. Nattenmüller, D. Sookthai, T. Nonnenmacher, M. E. Graf, L. Riedl, C. L. Schlett, O. von Stackelberg, T. Johnson, D. Nabers, et al. 2018. Effects of intermittent and continuous calorie restriction on body weight and metabolism over 50 wk: A randomized controlled trial. The American Journal of Clinical Nutrition 108 (5):933–45. doi: 10.1093/ajcn/nqy196.
   PubMed Web of Science ®Google Scholar
• Schwingshackl, L., and G. Hoffmann. 2013. Comparison of effects of long-term low-fat vs high-fat diets on blood lipid levels in overweight or obese patients: A systematic review and meta-analysis. Journal of the Academy of Nutrition and Dietetics 113 (12):1640–61. doi: 10.1016/j.jand.2013.07.010.
   PubMed Web of Science ®Google Scholar
• Sengupta, S., T. R. Peterson, M. Laplante, S. Oh, and D. M. Sabatini. 2010. mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature 468 (7327):1100–4. doi: 10.1038/nature09584.
   PubMed Web of Science ®Google Scholar
• Shi, D., T. Han, X. Chu, H. Lu, X. Yang, T. Zi, Y. Zhao, X. Wang, Z. Liu, J. Ruan, et al. 2021. An isocaloric moderately high-fat diet extends lifespan in male rats and Drosophila. Cell Metabolism 33 (3):581–97 e9. doi: 10.1016/j.cmet.2020.12.017.
   PubMed Web of Science ®Google Scholar
• Sichieri, R., J. E. Everhart, and H. Roth. 1991. A prospective-study of hospitalization with gallstone disease among women - role of dietary factors, fasting period, and dieting. American Journal of Public Health 81 (7):880–4. doi:10.2105/Ajph.81.7.880.
   PubMed Web of Science ®Google Scholar
• Solon-Biet, S. M., A. C. McMahon, J. W. O. Ballard, K. Ruohonen, L. E. Wu, V. C. Cogger, A. Warren, X. Huang, N. Pichaud, R. G. Melvin, et al. 2014. The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice. Cell Metabolism 19 (3):418–30. doi: 10.1016/j.cmet.2014.02.009.
   PubMed Web of Science ®Google Scholar
• Solon-Biet, S. M., V. C. Cogger, T. Pulpitel, D. Wahl, X. Clark, E. Bagley, G. C. Gregoriou, A. M. Senior, Q. P. Wang, A. E. Brandon, et al. 2019. Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control. Nature Metabolism 1 (5):532–45. doi: 10.1038/s42255-019-0059-2.
   PubMedGoogle Scholar
• Soultoukis, G. A., and L. Partridge. 2016. Dietary protein, metabolism, and aging. Annual Review of Biochemistry 85:5–34. doi: 10.1146/annurev-biochem-060815-014422.
   PubMed Web of Science ®Google Scholar
• Stekovic, S., S. J. Hofer, N. Tripolt, M. A. Aon, P. Royer, L. Pein, J. T. Stadler, T. Pendl, B. Prietl, J. Url, et al. 2019. Alternate day fasting improves physiological and molecular markers of aging in healthy, non-obese humans. Cell Metabolism 30 (3):462–76 e6. doi: 10.1016/j.cmet.2019.07.016.
   PubMed Web of Science ®Google Scholar
• Stokkan, K. A., S. Yamazaki, H. Tei, Y. Sakaki, and M. Menaker. 2001. Entrainment of the circadian clock in the liver by feeding. Science (New York, N.Y.) 291 (5503):490–3. doi: 10.1126/science.291.5503.490.
   PubMed Web of Science ®Google Scholar
• Sutton, E. F., R. Beyl, K. S. Early, W. T. Cefalu, E. Ravussin, and C. M. Peterson. 2018. Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes. Cell Metabolism 27 (6):1212–21.e3. +. doi: 10.1016/j.cmet.2018.04.010.
   PubMed Web of Science ®Google Scholar
• Tian, Q., J. Zhao, Q. Yang, B. Wang, J. M. Deavila, M. J. Zhu, and M. Du. 2020. Dietary alpha-ketoglutarate promotes beige adipogenesis and prevents obesity in middle-aged mice. Aging Cell 19 (1):e13059. doi: 10.1111/acel.13059.
   PubMed Web of Science ®Google Scholar
• Trepanowski, J. F., C. M. Kroeger, A. Barnosky, M. C. Klempel, S. Bhutani, K. K. Hoddy, K. Gabel, S. Freels, J. Rigdon, J. Rood, et al. 2017. Effect of alternate-day fasting on weight loss, weight maintenance, and cardioprotection among metabolically healthy obese adults: A randomized clinical trial. JAMA Internal Medicine 177 (7):930–8. doi: 10.1001/jamainternmed.2017.0936.
   PubMed Web of Science ®Google Scholar
• Wahl, D., S. M. Solon-Biet, Q. P. Wang, J. A. Wali, T. Pulpitel, X. Clark, D. Raubenheimer, A. M. Senior, D. A. Sinclair, G. J. Cooney, et al. 2018. Comparing the effects of low-protein and high-carbohydrate diets and caloric restriction on brain aging in mice. Cell Reports 25 (8):2234–43 e6. doi: 10.1016/j.celrep.2018.10.070.
   PubMed Web of Science ®Google Scholar
• Walford, R. L., D. Mock, R. Verdery, and T. MacCallum. 2002. Calorie restriction in biosphere 2: Alterations in physiologic, hematologic, hormonal, and biochemical parameters in humans restricted for a 2-year period. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 57 (6):B211–24. doi: 10.1093/gerona/57.6.b211.
   PubMed Web of Science ®Google Scholar
• Wali, J. A., A. J. Milner, A. W. S. Luk, T. J. Pulpitel, T. Dodgson, H. J. W. Facey, D. Wahl, M. A. Kebede, A. M. Senior, M. A. Sullivan, et al. 2021. Impact of dietary carbohydrate type and protein-carbohydrate interaction on metabolic health. Nature Metabolism 3 (6):810–28. doi: 10.1038/s42255-021-00393-9.
   PubMedGoogle Scholar
• Wang, Q., Y. Zhou, P. Rychahou, T. W. Fan, A. N. Lane, H. L. Weiss, and B. M. Evers. 2017. Ketogenesis contributes to intestinal cell differentiation. Cell Death and Differentiation 24 (3):458–68. doi: 10.1038/cdd.2016.142.
   PubMed Web of Science ®Google Scholar
• Wei, M., S. Brandhorst, M. Shelehchi, H. Mirzaei, C. W. Cheng, J. Budniak, S. Groshen, W. J. Mack, E. Guen, S. D. Biase, et al. 2017. Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Science Translational Medicine 9 (377):eaai8700. doi: 10.1126/scitranslmed.aai8700.
   PubMed Web of Science ®Google Scholar
• Willcox, B. J., D. C. Willcox, H. Todoriki, A. Fujiyoshi, K. Yano, Q. M. He, J. D. Curb, and M. Suzuki. 2007. Caloric restriction, the traditional Okinawan diet, and healthy aging - The diet of the world’s longest-lived people and its potential impact on morbidity and life span. Annals of the New York Academy of Sciences 1114:434–55. doi: 10.1196/annals.1396.037.
   PubMed Web of Science ®Google Scholar
• Woudstra, T., and A. B. Thomson. 2002. Nutrient absorption and intestinal adaptation with ageing. Best Practice & Research. Clinical Gastroenterology 16 (1):1–15. doi: 10.1053/bega.2001.0262.
   PubMed Web of Science ®Google Scholar
• Wu, J. H. Y., R. Micha, and D. Mozaffarian. 2019. Dietary fats and cardiometabolic disease: Mechanisms and effects on risk factors and outcomes. Nature Reviews. Cardiology 16 (10):581–601. doi: 10.1038/s41569-019-0206-1.
   PubMed Web of Science ®Google Scholar
• Wu, L., T. Zeng, A. Zinellu, S. Rubino, D. J. Kelvin, and C. Carru. 2019. A cross-sectional study of compositional and functional profiles of gut microbiota in Sardinian centenarians. Msystems 4 (4):e00325–19. doi: 10.1128/mSystems.00325-19.
   PubMed Web of Science ®Google Scholar
• Wu, Y., B. Li, L. Li, S. E. Mitchell, C. L. Green, G. D’Agostino, G. Wang, L. Wang, M. Li, J. Li, et al. 2021. Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice. Cell Metabolism 33 (6):1264–1266. doi: 10.1016/j.cmet.2021.01.017.
   PubMed Web of Science ®Google Scholar
• Wu, Z., M. Isik, N. Moroz, M. J. Steinbaugh, P. Zhang, and T. K. Blackwell. 2019. Dietary restriction extends lifespan through metabolic regulation of innate immunity. Cell Metabolism 29 (5):1192–205 e8. doi: 10.1016/j.cmet.2019.02.013.
   PubMed Web of Science ®Google Scholar
• Yeh, T. S., C. Yuan, A. Ascherio, B. A. Rosner, D. Blacker, and W. C. Willett. 2022. Long-term intake of total energy and fat in relation to subjective cognitive decline. European Journal of Epidemiology 37 (2):133–46. doi: 10.1007/s10654-021-00814-9.
   PubMed Web of Science ®Google Scholar
• Yokoyama, Y., K. Onishi, T. Hosoda, H. Amano, S. Otani, Y. Kurozawa, and A. Tamakoshi. 2016. Skipping breakfast and risk of mortality from cancer, circulatory diseases and all causes: Findings from the Japan Collaborative Cohort Study. Yonago Acta Medica 59 (1):55–60.
   PubMed Web of Science ®Google Scholar
• Youm, Y.-H., K. Y. Nguyen, R. W. Grant, E. L. Goldberg, M. Bodogai, D. Kim, D. D’Agostino, N. Planavsky, C. Lupfer, T. D. Kanneganti, et al. 2015. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease. Nature Medicine 21 (3):263–9. doi: 10.1038/nm.3804.
   PubMed Web of Science ®Google Scholar
• Yu, D., N. E. Richardson, C. L. Green, A. B. Spicer, M. E. Murphy, V. Flores, C. Jang, I. Kasza, M. Nikodemova, M. H. Wakai, 3rd, et al. 2021. The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine. Cell Metabolism 33 (5):905–922 e6. doi: 10.1016/j.cmet.2021.03.025.
   PubMed Web of Science ®Google Scholar
• Zarrinpar, A., A. Chaix, S. Yooseph, and S. Panda. 2014. Diet and feeding pattern affect the diurnal dynamics of the gut microbiome. Cell Metabolism 20 (6):1006–17. doi: 10.1016/j.cmet.2014.11.008.
   PubMed Web of Science ®Google Scholar
• Zeevi, D., T. Korem, N. Zmora, D. Israeli, D. Rothschild, A. Weinberger, O. Ben-Yacov, D. Lador, T. Avnit-Sagi, M. Lotan-Pompan, et al. 2015. Personalized nutrition by prediction of glycemic responses. Cell 163 (5):1079–94. doi: 10.1016/j.cell.2015.11.001.
   PubMed Web of Science ®Google Scholar
• Zhang, C., M. Zhang, S. Wang, R. Han, Y. Cao, W. Hua, Y. Mao, X. Zhang, X. Pang, C. Wei, et al. 2010. Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice. The ISME Journal 4 (2):232–41. doi: 10.1038/ismej.2009.112.
   PubMed Web of Science ®Google Scholar
• Zhang, C., S. Li, L. Yang, P. Huang, W. Li, S. Wang, G. Zhao, M. Zhang, X. Pang, Z. Yan, et al. 2013. Structural modulation of gut microbiota in life-long calorie-restricted mice. Nature Communications 4 (1):2163. doi: 10.1038/ncomms3163.
   PubMedGoogle Scholar
• Zhang, L., X. Xue, R. Zhai, X. Yang, H. Li, L. Zhao, and C. Zhang. 2019. Timing of calorie restriction in mice impacts host metabolic phenotype with correlative changes in gut microbiota. Msystems 4 (6):e00348–19. doi: 10.1128/mSystems.00348-19.
   PubMed Web of Science ®Google Scholar
• Zhang, Z., X. Chen, Y. J. Loh, X. Yang, and C. Zhang. 2021. The effect of calorie intake, fasting, and dietary composition on metabolic health and gut microbiota in mice. BMC Biology 19 (1):51. doi: 10.1186/s12915-021-00987-5.
   PubMed Web of Science ®Google Scholar
• Zhong, V. W., N. B. Allen, P. Greenland, M. R. Carnethon, H. Ning, J. T. Wilkins, D. M. Lloyd-Jones, and L. Van Horn. 2021. Protein foods from animal sources, incident cardiovascular disease and all-cause mortality: A substitution analysis. International Journal of Epidemiology 50 (1):223–33. doi: 10.1093/ije/dyaa205.
   PubMed Web of Science ®Google Scholar
• Zhou, Z. L., X. B. Jia, M. F. Sun, Y. L. Zhu, C. M. Qiao, B. P. Zhang, L. P. Zhao, Q. Yang, C. Cui, X. Chen, et al. 2019. Neuroprotection of fasting mimicking diet on MPTP-induced Parkinson’s disease mice via gut microbiota and metabolites. Neurotherapeutics : The Journal of the American Society for Experimental NeuroTherapeutics 16 (3):741–60. doi: 10.1007/s13311-019-00719-2.
   PubMed Web of Science ®Google Scholar
• Zimmerman, J. A., V. Malloy, R. Krajcik, and N. Orentreich. 2003. Nutritional control of aging. Experimental Gerontology 38 (1–2):47–52. doi: 10.1016/S0531-5565(02)00149-3.
   PubMed Web of Science ®Google Scholar
• Zou, K., S. Rouskin, K. Dervishi, M. A. McCormick, A. Sasikumar, C. H. Deng, Z. B. Chen, M. Kaeberlein, R. B. Brem, M. Polymenis, et al. 2020. Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span. Science Advances 6 (32):eaba1306. doi: 10.1126/sciadv.aba1306.
   PubMed Web of Science ®Google Scholar