Modulation of integrin receptor by polyphenols: Downstream Nrf2-Keap1/ARE and associated cross-talk mediators in cardiovascular diseases

References

• Abbasi, N., M. M. Akhavan, N. Rahbar-Roshandel, and M. Shafiei. 2014. The effects of low and high concentrations of luteolin on cultured human endothelial cells under normal and glucotoxic conditions: Involvement of integrin-linked kinase and cyclooxygenase-2. Phytotherapy Research: PTR 28 (9):1301–7. doi: 10.1002/ptr.5128.
   PubMed Web of Science ®Google Scholar
• Abbaszadeh, F., S. Fakhri, and H. Khan. 2020. Targeting apoptosis and autophagy following spinal cord injury: Therapeutic approaches to polyphenols and candidate phytochemicals. Pharmacological Research 160:105069. doi: 10.1016/j.phrs.2020.105069.
   PubMed Web of Science ®Google Scholar
• Abubaker, A. A., D. Vara, C. Visconte, I. Eggleston, M. Torti, I. Canobbio, and G. Pula. 2019. Amyloid peptide beta 1-42 induces integrin alpha IIb beta 3 activation, platelet adhesion, and thrombus formation in a NADPH oxidase-dependent manner. Oxidative Medicine and Cellular Longevity 2019:1050476. doi: 10.1155/2019/1050476.
   PubMed Web of Science ®Google Scholar
• Alhaithloul, H. A. S., M. F. Alotaibi, M. Bin-Jumah, H. Elgebaly, and A. M. Mahmoud. 2019. Olea europaea leaf extract up-regulates Nrf2/ARE/HO-1 signaling and attenuates cyclophosphamide-induced oxidative stress, inflammation and apoptosis in rat kidney. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 111:676–85. doi: 10.1016/j.biopha.2018.12.112.
   PubMed Web of Science ®Google Scholar
• Anandarajah, A. P. 2009. Role of RANKL in bone diseases. Trends in Endocrinology and Metabolism: TEM 20 (2):88–94. doi: 10.1016/j.tem.2008.10.007.
   PubMed Web of Science ®Google Scholar
• Annabi, B., Y. T. Lee, C. Martel, A. Pilorget, J. P. Bahary, and R. Beliveau. 2003. Radiation-induced tubulogenesis in endothelial cells is antagonized by the antiangiogenic properties of green tea polyphenol (-) epigallocatechin-3-gallate. Cancer Biology & Therapy 2 (6):642–9. doi: 10.4161/cbt.2.6.529.
   PubMed Web of Science ®Google Scholar
• Azumi, H., N. Inoue, Y. Ohashi, M. Terashima, T. Mori, H. Fujita, K. Awano, K. Kobayashi, K. Maeda, K. Hata, et al. 2002. Superoxide generation in directional coronary atherectomy specimens of patients with angina pectoris - Important role of NAD(P)H oxidase. Arteriosclerosis, Thrombosis, and Vascular Biology 22 (11):1838–44. doi: 10.1161/01.atv.0000037101.40667.62.
   PubMed Web of Science ®Google Scholar
• Barczyk, M., S. Carracedo, and D. Gullberg. 2010. Integrins. Cell and Tissue Research 339 (1):269–80. doi: 10.1007/s00441-009-0834-6.
   PubMed Web of Science ®Google Scholar
• Baril, P., R. Gangeswaran, P. C. Mahon, K. Caulee, H. M. Kocher, T. Harada, M. Zhu, H. Kalthoff, T. Crnogorac-Jurcevic, and N. R. Lemoine. 2007. Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: Role of the beta(4) integrin and the PI3k pathway. Oncogene 26 (14):2082–94. doi: 10.1038/sj.onc.1210009.
   PubMed Web of Science ®Google Scholar
• Barrett, T. J., M. Schlegel, F. Zhou, M. Gorenchtein, J. Bolstorff, K. J. Moore, E. A. Fisher, and J. S. Berger. 2019. Platelet regulation of myeloid suppressor of cytokine signaling 3 accelerates atherosclerosis. Science Translational Medicine 11 (517):eaax0481. doi: 10.1126/scitranslmed.aax0481.
   PubMed Web of Science ®Google Scholar
• Bates, R. C., D. I. Bellovin, C. Brown, E. Maynard, B. Y. Wu, H. Kawakatsu, D. Sheppard, P. Oettgen, and A. M. Mercurio. 2005. Transcriptional activation of integrin beta 6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. Journal of Clinical Investigation 115 (2):339–47. doi: 10.1172/JCI200523183.
   PubMed Web of Science ®Google Scholar
• Belleri, M., D. Ribatti, M. Savio, L. A. Stivala, L. Forti, E. Tanghetti, P. Alessi, D. Coltrini, A. Bugatti, S. Mitola, et al. 2008. alpha v beta 3 Integrin-dependent antiangiogenic activity of resveratrol stereoisomers. Molecular Cancer Therapeutics 7 (12):3761–70. doi: 10.1158/1535-7163.mct-07-2351.
   PubMed Web of Science ®Google Scholar
• Bijak, M., A. Dziedzic, and J. Saluk-Bijak. 2018. Flavonolignans reduce the response of blood platelet to collagen. International Journal of Biological Macromolecules 106:878–84. doi: 10.1016/j.ijbiomac.2017.08.091.
   PubMed Web of Science ®Google Scholar
• Biswas, S., A. Zimman, D. T. Gao, T. Byzova, and E. Podrez. 2017. TLR2 plays a key role in platelet hyperreactivity and accelerated thrombosis associated with hyperlipidemia. Circulation Research 121 (8):951–62. doi: 10.1161/CIRCRESAHA.117.311069.
   PubMed Web of Science ®Google Scholar
• Borza, C. M., and A. Pozzi. 2012. The role of cell-extracellular matrix interactions in glomerular injury. Experimental Cell Research 318 (9):1001–10. doi: 10.1016/j.yexcr.2012.02.033.
   PubMed Web of Science ®Google Scholar
• Borza, C. M., Y. Su, X. Chen, L. Yu, S. Mont, S. Chetyrkin, P. Voziyan, B. G. Hudson, P. C. Billings, H. Jo, et al. 2012. Inhibition of integrin alpha 2 beta 1 ameliorates glomerular injury. Journal of the American Society of Nephrology: JASN 23 (6):1027–38. doi: 10.1681/asn.2011040367.
   PubMed Web of Science ®Google Scholar
• Bose, C., I. Alves, P. Singh, P. T. Palade, E. Carvalho, E. Borsheim, S. R. Jun, A. Cheema, M. Boerma, S. Awasthi, et al. 2020. Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling. Aging Cell 19 (11):e13261. doi: 10.1111/acel.13261.
   PubMed Web of Science ®Google Scholar
• Bouvet, M., O. Claude, M. Roux, D. Skelly, N. Masurkar, N. Mougenot, S. Nadaud, C. Blanc, C. Delacroix, S. Chardonnet, et al. 2020. Anti-integrin α(v) therapy improves cardiac fibrosis after myocardial infarction by blunting cardiac PW1(+) stromal cells. Scientific Reports 10 (1):11404. doi: 10.1038/s41598-020-68223-8.
   PubMedGoogle Scholar
• Cannon, C. P. 2003. Small molecule glycoprotein IIb/IIIa receptor inhibitors as upstream therapy in acute coronary syndromes - Insights from the TACTICS TIMI-18 trial. Journal of the American College of Cardiology 41 (4 Suppl S):43S–8S. doi: 10.1016/S0735-1097(02)03018-8.
   PubMed Web of Science ®Google Scholar
• Canobbio, I., C. Visconte, B. Oliviero, G. Guidetti, M. Zara, G. Pula, and M. Torti. 2016. Increased platelet adhesion and thrombus formation in a mouse model of Alzheimer’s disease. Cellular Signalling 28 (12):1863–71. doi: 10.1016/j.cellsig.2016.08.017.
   PubMed Web of Science ®Google Scholar
• Cao, C. C., L. Dai, J. Y. Mu, X. F. Wang, Y. L. Hong, C. Zhu, L. Jin, and S. N. Li. 2019. S1PR2 antagonist alleviates oxidative stress-enhanced brain endothelial permeability by attenuating p38 and Erk1/2-dependent cPLA(2) phosphorylation. Cellular Signalling 53:151–61. doi: 10.1016/j.cellsig.2018.09.019.
   PubMed Web of Science ®Google Scholar
• Catalkaya, G., K. Venema, L. Lucini, G. Rocchetti, D. Delmas, M. Daglia, A. D. Filippis, H. Xiao, J. L. Quiles, J. Xiao, et al. 2020. Interaction of dietary polyphenols and gut microbiota: Microbial metabolism of polyphenols, influence on the gut microbiota, and implications on host health. Food Frontiers 1 (2):109–33. doi: 10.1002/fft2.25.
   Google Scholar
• Chang, C. C., C. F. Chu, C. N. Wang, H. T. Wu, K. W. Bi, J. H. S. Pang, and S. T. Huang. 2014. The anti-atherosclerotic effect of tanshinone IIA is associated with the inhibition of TNF-alpha-induced VCAM-1, ICAM-1 and CX3CL1 expression. Phytomedicine 21 (3):207–16. doi: 10.1016/j.phymed.2013.09.012.
   PubMed Web of Science ®Google Scholar
• Chang, J. Z.-C., Y.-P. Hsieh, W.-H. Lin, H.-M. Chen, and M. Y.-P. Kuo. 2017. Activation of transforming growth factor-1 by thrombin via integrins v1, v3, and v5 in buccal fibroblasts: Suppression by epigallocatechin-3-gallate. Head & Neck 39 (7):1436–45. doi: 10.1002/hed.24791.
   PubMed Web of Science ®Google Scholar
• Chang, S.-S., V. S. Y. Lee, Y.-L. Tseng, K.-C. Chang, K.-B. Chen, Y.-L. Chen, and C.-Y. Li. 2012. Gallic acid attenuates platelet activation and platelet-leukocyte aggregation: Involving pathways of Akt and GSK3 beta. Evidence-Based Complementary and Alternative Medicine: eCAM 2012:683872. doi: 10.1155/2012/683872.
   PubMed Web of Science ®Google Scholar
• Chang, Y., W.-F. Chen, K.-H. Lin, C.-Y. Hsieh, D.-S. Chou, L.-J. Lin, J.-R. Sheu, and C.-C. Chang. 2013. Novel bioactivity of ellagic acid in inhibiting human platelet activation. Evidence-Based Complementary and Alternative Medicine: eCAM 2013:595128. doi: 10.1155/2013/595128.
   PubMed Web of Science ®Google Scholar
• Chen, C., R. X. Li, R. S. Ross, and A. M. Manso. 2016. Integrins and integrin-related proteins in cardiac fibrosis. Journal of Molecular and Cellular Cardiology 93:162–74. doi: 10.1016/j.yjmcc.2015.11.010.
   PubMed Web of Science ®Google Scholar
• Chen, D.-D., Y.-G. Dong, D. Liu, and J.-G. He. 2009. Epigallocatechin-3-gallate attenuates cardiac hypertrophy in hypertensive rats in part by modulation of mitogen-activated protein kinase signals. Clinical and Experimental Pharmacology & Physiology 36 (9):925–32. doi: 10.1111/j.1440-1681.2009.05173.x.
   PubMed Web of Science ®Google Scholar
• Chen, J., R. Guo, H. Yan, L. Tian, Q. You, S. Li, R. Huang, and K. Wu. 2014. Naringin inhibits ROS-activated MAPK pathway in high glucose-induced injuries in H9c2 cardiac cells. Basic & Clinical Pharmacology & Toxicology 114 (4):293–304. doi: 10.1111/bcpt.12153.
   PubMed Web of Science ®Google Scholar
• Chen, L., X. Y. Fan, X. J. Lin, L. Qian, G. Zengin, D. Delmas, P. Paoli, H. Teng, and J. B. Xiao. 2020. Phenolic extract from Sonchus oleraceus L. protects diabetes-related liver injury in rats through TLR4/NF-κB signaling pathway. eFood 1 (1):77–84. doi: 10.2991/efood.k.191018.002.
   Google Scholar
• Chen, R. C., G. B. Sun, J. Wang, H. J. Zhang, and X. B. Sun. 2015. Naringin protects against anoxia/reoxygenation-induced apoptosis in H9c2 cells via the Nrf2 signaling pathway. Food & Function 6 (4):1331–44. doi: 10.1039/c4fo01164c.
   PubMed Web of Science ®Google Scholar
• Chen, S., Y. Ding, W. Tao, W. Zhang, T. Liang, and C. Liu. 2012. Naringenin inhibits TNF-alpha induced VSMC proliferation and migration via induction of HO-1. Food and Chemical Toxicology 50 (9):3025–31. doi: 10.1016/j.fct.2012.06.006.
   PubMed Web of Science ®Google Scholar
• Chen, X., T. D. Abair, M. R. Ibanez, Y. Su, M. R. Frey, R. S. Dise, D. B. Polk, A. B. Singh, R. C. Harris, R. Zent, et al. 2007. Integrin alpha 1 beta 1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation. Molecular and Cellular Biology 27 (9):3313–26. doi: 10.1128/mcb.01476-06.
   PubMed Web of Science ®Google Scholar
• Chen, X. M., J. Z. Lin, T. T. Hu, Z. Y. Ren, L. N. Li, I. Hameed, X. Y. Zhang, C. Men, Y. Guo, D. Xu, et al. 2019. Galectin-3 exacerbates ox-LDL-mediated endothelial injury by inducing inflammation via integrin 1-RhoA-JNK signaling activation. Journal of Cellular Physiology 234 (7):10990–1000. doi: 10.1002/jcp.27910.
   PubMed Web of Science ®Google Scholar
• Chen, X. W., G. Moeckel, J. D. Morrow, D. Cosgrove, R. C. Harris, A. B. Fogo, R. Zent, and A. Pozzi. 2004. Lack of integrin alpha 1 beta 1 leads to severe glomerulosclerosis after glomerular injury. The American Journal of Pathology 165 (2):617–30. doi: 10.1016/S0002-9440(10)63326-3.
   PubMed Web of Science ®Google Scholar
• Chi, J. Y., S. X. Yu, C. N. Liu, X. Y. Zhao, J. Y. Zhong, Y. T. Liang, N. Ta, X. H. Yin, and D. C. Zhao. 2018. Nox4-dependent ROS production is involved in CVB3-induced myocardial apoptosis. Biochemical and Biophysical Research Communications 503 (3):1641–4. doi: 10.1016/j.bbrc.2018.07.093.
   PubMed Web of Science ®Google Scholar
• Civitarese, R. A., A. Kapus, C. A. McCulloch, and K. A. Connelly. 2017. Role of integrins in mediating cardiac fibroblast-cardiomyocyte cross talk: A dynamic relationship in cardiac biology and pathophysiology. Basic Research in Cardiology 112 (1):6. doi: 10.1007/s00395-016-0598-6.
   PubMed Web of Science ®Google Scholar
• Clemetson, K. J., and J. M. Clemetson. 1998. Integrins and cardiovascular disease. Cellular and Molecular Life Sciences: CMLS 54 (6):502–13. doi: 10.1007/s000180050179.
   PubMed Web of Science ®Google Scholar
• Cominacini, L., M. Anselmi, U. Garbin, A. Fratta Pasini, C. Stranieri, M. Fusaro, C. Nava, P. Agostoni, D. Keta, P. Zardini, et al. 2005. Enhanced plasma levels of oxidized low-density lipoprotein increase circulating nuclear factor-kappa B activation in patients with unstable angina. Journal of the American College of Cardiology 46 (5):799–806. doi: 10.1016/j.jacc.2005.05.063.
   PubMed Web of Science ®Google Scholar
• Crespo-Cuevas, A. M., T. Canento, M. Hernandez-Perez, C. Caceres, A. Gonzalez, L. Ispierto, M. Mataro, D. Vilas, A. Planas-Ballve, L. Martin, et al. 2020. The barcelona-asymptomatic intracranial atherosclerosis (AsIA) study: Subclinical cervico-cerebral stenosis and middle cerebral artery pulsatility index as predictors of long-term incident cognitive impairment. Atherosclerosis 312:104–9. doi: 10.1016/j.atherosclerosis.2020.08.025.
   PubMed Web of Science ®Google Scholar
• Cui, G., L. Shan, M. Hung, S. Lei, I. Choi, Z. Zhang, P. Yu, P. Hoi, Y. Wang, and S. M. Lee. 2013. A novel Danshensu derivative confers cardioprotection via PI3K/Akt and Nrf2 pathways. International Journal of Cardiology 168 (2):1349–59. doi: 10.1016/j.ijcard.2012.12.012.
   PubMed Web of Science ®Google Scholar
• Dabiri, B. E., H. Lee, and K. K. Parker. 2012. A potential role for integrin signaling in mechanoelectrical feedback. Progress in Biophysics and Molecular Biology 110 (2–3):196–203. doi: 10.1016/j.pbiomolbio.2012.07.002.
   PubMed Web of Science ®Google Scholar
• Das, K., S. Nimushakavi, A. Chaudhuri, and P. K. Das. 2017. An integrin-targeting RGDK-tagged nanocarrier: Anticancer efficacy of loaded curcumin. ChemMedChem 12 (10):738–50. doi: 10.1002/cmdc.201700085.
   PubMed Web of Science ®Google Scholar
• Dawoud, H., and T. Malinski. 2020. Vitamin D3, L-arginine, L-citrulline, and antioxidant supplementation enhances nitric oxide bioavailability and reduces oxidative stress in the vascular endothelium - Clinical implications for cardiovascular system. Pharmacognosy Research 12 (1):17–23. doi: 10.4103/pr.pr_79_19.
   Web of Science ®Google Scholar
• Du, J. X., W. He, C. Zhang, J. Z. Wu, Z. Li, M. Wang, S. Y. Feng, and G. F. Liang. 2020. Pentamethylquercetin attenuates cardiac remodeling via activation of the Sestrins/Keap1/Nrf2 pathway in MSG-induced obese mice. BioMed Research International 2020:3243906. doi: 10.1155/2020/3243906.
   PubMed Web of Science ®Google Scholar
• Duan, J., Y. Guan, F. Mu, C. Guo, E. Zhang, Y. Yin, G. Wei, Y. Zhu, J. Cui, J. Cao, et al. 2017. Protective effect of butin against ischemia/reperfusion-induced myocardial injury in diabetic mice: Involvement of the AMPK/GSK-3β/Nrf2 signaling pathway. Scientific Reports 7:41491. doi: 10.1038/srep41491.
   PubMed Web of Science ®Google Scholar
• Durrant, T. N., M. T. van den Bosch, and I. Hers. 2017. Integrin αIIbβ3 outside-in signaling. Blood 130 (14):1607–19. doi: 10.1182/blood-2017-03-773614.
   PubMed Web of Science ®Google Scholar
• Ethaeb, A. M., M. A. Mohammad, Y. Madkhali, S. Featherby, A. Maraveyas, J. Greenman, and C. Ettelaie. 2020. Accumulation of tissue factor in endothelial cells promotes cellular apoptosis through over-activation of Src1 and involves beta 1-integrin signalling. Apoptosis 25 (1–2):29–41. doi: 10.1007/s10495-019-01576-2.
   PubMed Web of Science ®Google Scholar
• Fakhri, S., S. Z. Moradi, M. H. Farzaei, and A. Bishayee. 2022. Modulation of dysregulated cancer metabolism by plant secondary metabolites: A mechanistic review. Seminars in Cancer Biology 80:276–305. doi: 10.1016/j.semcancer.2020.02.007.
   PubMed Web of Science ®Google Scholar
• Fan, C., Y. Kawai, S. Inaba, K. Arakawa, M. Katsuyama, K. Kajinami, T. Yasuda, C. Yabe-Nishimura, T. Konoshita, and I. Miyamori. 2008. Synergy of aldosterone and high salt induces vascular smooth muscle hypertrophy through up-regulation of NOX1. The Journal of Steroid Biochemistry and Molecular Biology 111 (1–2):29–36. doi: 10.1016/j.jsbmb.2008.02.012.
   PubMed Web of Science ®Google Scholar
• Fan, H., L. Yang, F. Fu, H. Xu, Q. Meng, H. Zhu, L. Teng, M. Yang, L. Zhang, Z. Zhang, et al. 2012. Cardioprotective effects of salvianolic acid A on myocardial ischemia-reperfusion injury in vivo and in vitro. Evidence-Based Complementary and Alternative Medicine: eCAM 2012:508938–9. doi: 10.1155/2012/508938.
   PubMed Web of Science ®Google Scholar
• Fathi, R., K. Nasiri, A. Akbari, F. Ahmadi-KaniGolzar, and Z. Farajtabar. 2020. Exercise protects against ethanol-induced damage in rat heart and liver through the inhibition of apoptosis and activation of Nrf2/Keap-1/HO-1 pathway. Life Sciences 256:117958. doi: 10.1016/j.lfs.2020.117958.
   PubMed Web of Science ®Google Scholar
• Feng, J., J. Luo, L. Deng, Y. Zhong, X. Wen, Y. Cai, and J. Li. 2019. Naringenin-induced HO-1 ameliorates high glucose or free fatty acids-associated apoptosis via PI3K and JNK/Nrf2 pathways in human umbilical vein endothelial cells. International Immunopharmacology 75:105769. doi: 10.1016/j.intimp.2019.105769.
   PubMed Web of Science ®Google Scholar
• Finney, A. C., K. Y. Stokes, C. B. Pattillo, and A. W. Orr. 2017. Integrin signaling in atherosclerosis. Cellular and Molecular Life Sciences: CMLS 74 (12):2263–82. doi: 10.1007/s00018-017-2490-4.
   PubMed Web of Science ®Google Scholar
• Fuentes, E., J. M. Gibbins, L. M. Holbrook, and I. Palomo. 2018. NADPH oxidase 2 (NOX2): A key target of oxidative stress-mediated platelet activation and thrombosis. Trends in Cardiovascular Medicine 28 (7):429–34. doi: 10.1016/j.tcm.2018.03.001.
   PubMed Web of Science ®Google Scholar
• Fuentes, F., M. Alarcón, L. Badimon, M. Fuentes, K. N. Klotz, G. Vilahur, S. Kachler, T. Padró, I. Palomo, and E. Fuentes. 2017. Guanosine exerts antiplatelet and antithrombotic properties through an adenosine-related cAMP-PKA signaling. International Journal of Cardiology 248:294–300. doi: 10.1016/j.ijcard.2017.08.006.
   PubMed Web of Science ®Google Scholar
• Garcia-Redondo, A. B., A. Aguado, A. M. Briones, and M. Salaices. 2016. NADPH oxidases and vascular remodeling in cardiovascular diseases. Pharmacological Research 114:110–20. doi: 10.1016/j.phrs.2016.10.015.
   PubMed Web of Science ®Google Scholar
• Ghosh, J., J. Das, P. Manna, and P. C. Sil. 2011. The protective role of arjunolic acid against doxorubicin induced intracellular ROS dependent JNK-p38 and p53-mediated cardiac apoptosis. Biomaterials 32 (21):4857–66. doi: 10.1016/j.biomaterials.2011.03.048.
   PubMed Web of Science ®Google Scholar
• Ghosh, N., I. Garg, S. Srivastava, and B. Kumar. 2021. Influence of integrins on thrombus formation: A road leading to the unravelling of DVT. Molecular and Cellular Biochemistry 476 (3):1489–504. doi: 10.1007/s11010-020-03961-x.
   PubMed Web of Science ®Google Scholar
• Gilio, K., M. T. Harper, J. Cosemans, O. Konopatskaya, I. C. A. Munnix, L. Prinzen, M. Leitges, Q. Liu, J. D. Molkentin, J. W. M. Heemskerk, et al. 2010. Functional divergence of platelet protein kinase C (PKC) isoforms in thrombus formation on collagen. Journal of Biological Chemistry 285 (30):23410–9. doi: 10.1074/jbc.M110.136176.
   PubMed Web of Science ®Google Scholar
• Gorbunov, N., G. Petrovski, N. Gurusamy, D. Ray, D. H. Kim, and D. K. Das. 2012. Regeneration of infarcted myocardium with resveratrol-modified cardiac stem cells. Journal of Cellular and Molecular Medicine 16 (1):174–84. doi: 10.1111/j.1582-4934.2011.01281.x.
   PubMed Web of Science ®Google Scholar
• Gowert, N. S., L. Donner, M. Chatterjee, Y. S. Eisele, S. T. Towhid, P. Münzer, B. Walker, I. Ogorek, O. Borst, M. Grandoch, et al. 2014. Blood platelets in the progression of Alzheimer’s disease. PLoS One 9 (2):e90523. doi: 10.1371/journal.pone.0090523.
   PubMed Web of Science ®Google Scholar
• Höök, P., R. I. Litvinov, O. V. Kim, S. Xu, Z. Xu, J. S. Bennett, M. S. Alber, and J. W. Weisel. 2017. Strong binding of platelet integrin αIIbβ3 to fibrin clots: Potential target to destabilize thrombi. Scientific Reports 7 (1):13001. doi: 10.1038/s41598-017-12615-w.
   PubMedGoogle Scholar
• Ha, H., H. B. Kwak, S. W. Lee, H. M. Jin, H. M. Kim, H. H. Kim, and Z. H. Lee. 2004. Reactive oxygen species mediate RANK signaling in osteoclasts. Experimental Cell Research 301 (2):119–27. doi: 10.1016/j.yexcr.2004.07.035.
   PubMed Web of Science ®Google Scholar
• Häuselmann, S. P., B. I. Rosc-Schlüter, V. Lorenz, I. Plaisance, M. Brink, O. Pfister, and G. M. Kuster. 2011. beta(1)-Integrin is up-regulated via Rac1-dependent reactive oxygen species as part of the hypertrophic cardiomyocyte response. Free Radical Biology & Medicine 51 (3):609–18. doi: 10.1016/j.freeradbiomed.2011.05.007.
   PubMed Web of Science ®Google Scholar
• Hai, Y., Y. Zhang, Y. Liang, X. Ma, X. Qi, J. Xiao, W. Xue, Y. Luo, and T. Yue. 2020. Advance on the absorption, metabolism, and efficacy exertion of quercetin and its important derivatives: Absorption, metabolism and function of quercetin. Food Frontiers 1 (4):420–34. doi: 10.1002/fft2.50.
   Google Scholar
• Haider, U. G. B., D. Sorescu, K. K. Griendling, A. M. Vollmar, and V. M. Dirsch. 2002. Resveratrol suppresses angiotensin II-induced Akt/protein kinase B and p70 S6 kinase phosphorylation and subsequent hypertrophy in rat aortic smooth muscle cells. Molecular Pharmacology 62 (4):772–7. doi: 10.1124/mol.62.4.772.
   PubMed Web of Science ®Google Scholar
• Han, J. J., J. Hao, C. H. Kim, J. S. Hong, H. Y. Ahn, and Y. S. Lee. 2009. Quercetin prevents cardiac hypertrophy induced by pressure overload in rats. Journal of Veterinary Medical Science 71 (6):737–43. doi: 10.1292/jvms.71.737.
   PubMed Web of Science ®Google Scholar
• Han, Y.-S., L. Lan, J. Chu, W.-Q. Kang, and Z.-M. Ge. 2013. Epigallocatechin gallate attenuated the activation of rat cardiac fibroblasts induced by angiotensin II via regulating beta-Arrestin1. Cellular Physiology and Biochemistry 31 (2–3):338–46. doi: 10.1159/000343371.
   PubMedGoogle Scholar
• Hannigan, G. E., J. G. Coles, and S. Dedhar. 2007. Integrin-linked kinase at the heart of cardiac contractility, repair, and disease. Circulation Research 100 (10):1408–14. doi: 10.1161/01.res.0000265233.40455.62.
   PubMed Web of Science ®Google Scholar
• Hao, E., F. Lang, Y. Chen, H. Zhang, X. Cong, X. Shen, and G. Su. 2013. Resveratrol alleviates endotoxin-induced myocardial toxicity via the Nrf2 transcription factor. PLoS One 8 (7):e69452. doi: 10.1371/journal.pone.0069452.
   PubMed Web of Science ®Google Scholar
• Hartland, S. N., F. Murphy, R. L. Aucott, A. Abergel, X. Y. Zhou, J. Waung, N. Patel, C. Bradshaw, J. Collins, D. Mann, et al. 2009. Active matrix metalloproteinase-2 promotes apoptosis of hepatic stellate cells via the cleavage of cellular N-cadherin. Liver International 29 (7):966–78. doi: 10.1111/j.1478-3231.2009.02070.x.
   PubMed Web of Science ®Google Scholar
• He, Y., Y. Fu, M. Xi, H. Zheng, Y. Zhang, Y. Liu, Y. Zhao, J. Xi, and Y. He. 2020. Zn2+ and mPTP mediate resveratrol-induced myocardial protection from endoplasmic reticulum stress. Metallomics: Integrated Biometal Science 12 (2):290–300. doi: 10.1039/c9mt00264b.
   PubMed Web of Science ®Google Scholar
• He, Y. Z., X. P. Cao, X. S. Liu, X. C. Li, Y. J. Xu, J. Liu, and J. Shi. 2015. Quercetin reverses experimental pulmonary arterial hypertension by modulating the TrkA pathway. Experimental Cell Research 339 (1):122–34. doi: 10.1016/j.yexcr.2015.10.013.
   PubMed Web of Science ®Google Scholar
• Heo, S.-D., J. Kim, Y. Choi, P. Ekanayake, M. Ahn, and T. Shin. 2020. Hesperidin improves motor disability in rat spinal cord injury through anti-inflammatory and antioxidant mechanism via Nrf-2/HO-1 pathway. Neuroscience Letters 715:134619. doi: 10.1016/j.neulet.2019.134619.
   PubMed Web of Science ®Google Scholar
• Higbee, J., P. Solverson, M. Zhu, and F. Carbonero. 2022. The emerging role of dark berry polyphenols in human health and nutrition. Food Frontiers 3 (1):3–27. doi: 10.1002/fft2.128.
   Google Scholar
• Honore, S., H. Kovacic, W. Pichard, C. Briand, and J. B. Rognoni. 2003. Alpha 2 beta 1-integrin signaling by itself controls G1/S transition in a human adenocarcinoma cell line (Caco-2): Implication of NADPH oxidase-dependent production of ROS. Experimental Cell Research 285 (1):59–71. doi: 10.1016/S0014-4827(02)00038-1.
   PubMed Web of Science ®Google Scholar
• Hsiao, G., J. J. Lee, K. H. Lin, C. H. Shen, T. H. Fong, D. S. Chou, and J. R. Sheu. 2007. Characterization of a novel and potent collagen antagonist, caffeic acid phenethyl ester, in human platelets: In vitro and in vivo studies. Cardiovascular Research 75 (4):782–92. doi: 10.1016/j.cardiores.2007.05.005.
   PubMed Web of Science ®Google Scholar
• Hu, T., G. Wei, M. Xi, J. Yan, X. Wu, Y. Wang, Y. Zhu, C. Wang, and A. Wen. 2016. Synergistic cardioprotective effects of Danshensu and hydroxysafflor yellow A against myocardial ischemia-reperfusion injury are mediated through the Akt/Nrf2/HO-1 pathway. International Journal of Molecular Medicine 38 (1):83–94. doi: 10.3892/ijmm.2016.2584.
   PubMed Web of Science ®Google Scholar
• Hung, W.-Y., K.-H. Huang, C.-W. Wu, C.-W. Chi, H.-L. Kao, A. F.-Y. Li, P.-H. Yin, and H.-C. Lee. 2012. Mitochondrial dysfunction promotes cell migration via reactive oxygen species-enhanced beta 5-integrin expression in human gastric cancer SC-M1 cells. Biochimica et Biophysica Acta 1820 (7):1102–10. doi: 10.1016/j.bbagen.2012.04.016.
   PubMed Web of Science ®Google Scholar
• Incalza, M. A., R. D’Oria, A. Natalicchio, S. Perrini, L. Laviola, and F. Giorgino. 2018. Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases. Vascular Pharmacology 100:1–19. doi: 10.1016/j.vph.2017.05.005.
   PubMed Web of Science ®Google Scholar
• Israeli-Rosenberg, S., A. M. Manso, H. Okada, and R. S. Ross. 2014. Integrins and integrin-associated proteins in the cardiac myocyte. Circulation Research 114 (3):572–86. doi: 10.1161/circresaha.114.301275.
   PubMed Web of Science ®Google Scholar
• Jakubczyk, K., K. Dec, J. Kaldunska, D. Kawczuga, J. Kochman, and K. Janda. 2020. Reactive oxygen species - Sources, functions, oxidative damage. Polski Merkuriusz Lekarski. Organ Polskiego Towarzystwa Lekarskiego 48 (284):124–7.
   PubMedGoogle Scholar
• Javkhedkar, A. A., Y. Quiroz, B. Rodriguez-Iturbe, N. D. Vaziri, M. F. Lokhandwala, and A. A. Banday. 2015. Resveratrol restored Nrf2 function, reduced renal inflammation, and mitigated hypertension in spontaneously hypertensive rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 308 (10):R840–R846. doi: 10.1152/ajpregu.00308.2014.
   PubMed Web of Science ®Google Scholar
• Jay, D. B., C. A. Papaharalambus, B. Seidel-Rogol, A. E. Dikalova, B. Lassegue, and K. K. Griendling. 2008. Nox5 mediates PDGF-induced proliferation in human aortic smooth muscle cells. Free Radical Biology & Medicine 45 (3):329–35. doi: 10.1016/j.freeradbiomed.2008.04.024.
   PubMed Web of Science ®Google Scholar
• Jayasooriya, R. G., M. G. Dilshara, S. R. Park, Y. H. Choi, J. W. Hyun, W. Y. Chang, and G. Y. Kim. 2014. 18β-Glycyrrhetinic acid suppresses TNF-α induced matrix metalloproteinase-9 and vascular endothelial growth factor by suppressing the Akt-dependent NF-κB pathway. Toxicology In Vitro 28 (5):751–8. doi: 10.1016/j.tiv.2014.02.015.
   PubMed Web of Science ®Google Scholar
• Jia, P., Y. J. Xu, Z. L. Zhang, K. Li, B. Li, W. Zhang, and H. Yang. 2012. Ferric ion could facilitate osteoclast differentiation and bone resorption through the production of reactive oxygen species. Journal of Orthopaedic Research 30 (11):1843–52. doi: 10.1002/jor.22133.
   PubMed Web of Science ®Google Scholar
• Jiang, Y. Q., G. L. Chang, Y. Wang, D. Y. Zhang, L. Cao, and J. Liu. 2016. Geniposide prevents hypoxia/reoxygenation-induced apoptosis in H9c2 cells: Improvement of mitochondrial dysfunction and activation of GLP-1R and the PI3K/AKT signaling pathway. Cellular Physiology and Biochemistry 39 (1):407–21. doi: 10.1159/000445634.
   PubMedGoogle Scholar
• Jiang, Z. H., L. Y. Fu, Y. N. Xu, X. X. Hu, H. Yang, Y. Y. Zhang, H. Luo, S. Q. Gan, L. Tao, G. Y. Liang, et al. 2020. Cyclovirobuxine D protects against diabetic cardiomyopathy by activating Nrf2-mediated antioxidant responses. Scientific Reports 10 (1):6427. doi: 10.1038/s41598-020-63498-3.
   PubMed Web of Science ®Google Scholar
• Juang, D., A. C. Braverman, and K. Eagle. 2008. Aortic dissection. Circulation 118 (14):E507–E510. doi: 10.1161/circulationaha.108.799908.
   PubMed Web of Science ®Google Scholar
• Judkins, C. P., H. Diep, B. R. S. Broughton, A. E. Mast, E. U. Hooker, A. A. Miller, S. Selemidis, G. J. Dusting, C. G. Sobey, and G. R. Drummond. 2010. Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE(-/-) mice. American Journal of Physiology. Heart and Circulatory Physiology 298 (1):H24–H32. doi: 10.1152/ajpheart.00799.2009.
   PubMed Web of Science ®Google Scholar
• Kadry, Y. A., and D. A. Calderwood. 2020. Chapter 22: Structural and signaling functions of integrins. Biochimica et Biophysica Acta. Biomembranes 1862 (5):183206. doi: 10.1016/j.bbamem.2020.183206.
   PubMed Web of Science ®Google Scholar
• Kanaan, G. N., and M.-E. Harper. 2017. Cellular redox dysfunction in the development of cardiovascular diseases. Biochimica et Biophysica Acta. General Subjects 1861 (11 Pt A):2822–9. doi: 10.1016/j.bbagen.2017.07.027.
   PubMed Web of Science ®Google Scholar
• Kanamori, H., G. Takemura, K. Goto, A. Tsujimoto, A. Ogino, T. Takeyama, T. Kawaguchi, T. Watanabe, K. Morishita, M. Kawasaki, et al. 2013. Resveratrol reverses remodeling in hearts with large, old myocardial infarctions through enhanced autophagy-activating AMP kinase pathway. The American Journal of Pathology 182 (3):701–13. doi: 10.1016/j.ajpath.2012.11.009.
   PubMed Web of Science ®Google Scholar
• Kaneider, N. C., B. Mosheimer, N. Reinisch, J. R. Patsch, and C. J. Wiedermann. 2004. Inhibition of thrombin-induced signaling by resveratrol and quercetin: Effects on adenosine nucleotide metabolism in endothelial cells and platelet-neutrophil interactions. Thrombosis Research 114 (3):185–94. doi: 10.1016/j.thromres.2004.06.020.
   PubMed Web of Science ®Google Scholar
• Kangarlou, S., S. Ramezanpour, S. Balalaie, S. R. Mohammadi, and I. Haririan. 2017. Curcumin-loaded nanoliposomes linked to homing peptides for integrin targeting and neuropilin-1-mediated internalization. Pharmaceutical Biology 55 (1):277–85. doi: 10.1080/13880209.2016.1261301.
   PubMed Web of Science ®Google Scholar
• Kapakos, G., V. Youreva, and A. K. Srivastava. 2012. Attenuation of endothelin-1-induced PKB and ERK1/2 signaling, as well as Egr-1 expression, by curcumin in A-10 vascular smooth muscle cells. Canadian Journal of Physiology and Pharmacology 90 (9):1277–85. doi: 10.1139/y2012-059.
   PubMed Web of Science ®Google Scholar
• Kattoor, A. J., N. V. K. Pothineni, D. Palagiri, and J. L. Mehta. 2017. Oxidative stress in atherosclerosis. Current Atherosclerosis Reports 19 (11):42. doi: 10.1007/s11883-017-0678-6.
   PubMed Web of Science ®Google Scholar
• Ke, A.-W., G.-M. Shi, J. Zhou, X.-Y. Huang, Y.-H. Shi, Z.-B. Ding, X.-Y. Wang, R. P. Devbhandari, and J. Fan. 2011. CD151 amplifies signaling by integrin alpha 6 beta 1 to PI3K and induces the epithelial-mesenchymal transition in HCC cells. Gastroenterology 140 (5):1629–41.e15. doi: 10.1053/j.gastro.2011.02.008.
   PubMed Web of Science ®Google Scholar
• Kensler, T. W., N. Wakabayash, and S. Biswal. 2007. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annual Review of Pharmacology and Toxicology 47:89–116. doi: 10.1146/annurev.pharmtox.46.120604.141046.
   PubMed Web of Science ®Google Scholar
• Kereiakes, D. J., T. M. Broderick, E. M. Roth, D. Whang, T. Shimshak, J. P. Runyon, C. Hattemer, J. Schneider, P. Lacock, M. Mueller, et al. 1999. Time course, magnitude, and consistency of platelet inhibition by abciximab, tirofiban, or eptifibatide in patients with unstable angina pectoris undergoing percutaneous coronary intervention. The American Journal of Cardiology 84 (4):391–5. doi: 10.1016/s0002-9149(99)00321-5.
   PubMed Web of Science ®Google Scholar
• Khan, H., H. Ullah, R. Tundis, T. Belwal, H. P. Devkota, M. Daglia, Z. Cetin, E. I. Saygili, M. Campos, E. Capanoglu, et al. 2020. Dietary flavonoids in the management of Huntington’s disease: Mechanism and clinical perspective. eFood 1 (1):38–52. doi: 10.2991/efood.k.200203.001.
   Google Scholar
• Kim, S. D., I.-K. Lee, W. M. Lee, J. Y. Cho, H. J. Park, J.-W. Oh, S. C. Park, S. K. Kim, Y. S. Kwak, B.-S. Yun, et al. 2008. The mechanism of anti-platelet activity of davallialactone: Involvement of intracellular calcium ions, extracellular signal-regulated kinase 2 and p38 mitogen-activated protein kinase. European Journal of Pharmacology 584 (2–3):361–7. doi: 10.1016/j.ejphar.2008.02.008.
   PubMed Web of Science ®Google Scholar
• Kim, T. J., J. H. Kim, Y. R. Jin, and Y. P. Yun. 2006. The inhibitory effect and mechanism of luteolin 7-glucoside on rat aortic vascular smooth muscle cell proliferation. Archives of Pharmacal Research 29 (1):67–72. doi: 10.1007/bf02977471.
   PubMed Web of Science ®Google Scholar
• Kim, Y. S., J. S. Kwon, Y. K. Cho, M. H. Jeong, J. G. Cho, J. C. Park, J. C. Kang, and Y. Ahn. 2012. Curcumin reduces the cardiac ischemia-reperfusion injury: Involvement of the toll-like receptor 2 in cardiomyocytes. The Journal of Nutritional Biochemistry 23 (11):1514–23. doi: 10.1016/j.jnutbio.2011.10.004.
   PubMed Web of Science ®Google Scholar
• Kobayashi, N., Y. Kadono, A. Naito, K. Matsumoto, T. Yamamoto, S. Tanaka, and J. Inoue. 2001. Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis. The EMBO Journal 20 (6):1271–80. doi: 10.1093/emboj/20.6.1271.
   PubMed Web of Science ®Google Scholar
• Kuo, L. M., P. J. Chen, P. J. Sung, Y. C. Chang, C. T. Ho, Y. H. Wu, and T. L. Hwang. 2018. The bioactive extract of pinnigorgia sp induces apoptosis of hepatic stellate cells via ROS-ERK/JNK-Caspase-3 signaling. Marine Drugs 16 (1):19. doi: 10.3390/md16010019.
   PubMed Web of Science ®Google Scholar
• Lassegue, B., and K. K. Griendling. 2010. NADPH oxidases: Functions and pathologies in the vasculature. Arteriosclerosis, Thrombosis, and Vascular Biology 30 (4):653–61. doi: 10.1161/atvbaha.108.181610.
   PubMed Web of Science ®Google Scholar
• Lee, E.-J., G.-S. Moon, W.-S. Choi, W.-J. Kim, and S.-K. Moon. 2008. Naringin-induced p21WAF1-mediated G(1)-phase cell cycle arrest via activation of the Ras/Raf/ERK signaling pathway in vascular smooth muscle cells. Food and Chemical Toxicology 46 (12):3800–7. doi: 10.1016/j.fct.2008.10.002.
   PubMed Web of Science ®Google Scholar
• Lee, E.-S., S.-H. Park, M. S. Kim, S.-Y. Han, H.-S. Kim, and Y.-H. Kang. 2012. Caffeic acid disturbs monocyte adhesion onto cultured endothelial cells stimulated by adipokine resistin. Journal of Agricultural and Food Chemistry 60 (10):2730–9. doi: 10.1021/jf203774y.
   PubMed Web of Science ®Google Scholar
• Lee, J., H. S. Son, H. I. Lee, G.-R. Lee, Y.-J. Jo, S.-E. Hong, N. Kim, M. Kwon, N. Y. Kim, H. J. Kim, et al. 2019. Skullcapflavone II inhibits osteoclastogenesis by regulating reactive oxygen species and attenuates the survival and resorption function of osteoclasts by modulating integrin signaling. FASEB Journal 33 (2):2026–36. doi: 10.1096/fj.201800866RR.
   PubMed Web of Science ®Google Scholar
• Lee, M. Y., A. San Martin, P. K. Mehta, A. E. Dikalova, A. M. Garrido, S. R. Datla, E. Lyons, K. H. Krause, B. Banfi, J. D. Lambeth, et al. 2009. Mechanisms of vascular smooth muscle NADPH oxidase 1 (Nox1) contribution to injury-induced neointimal formation. Arteriosclerosis, Thrombosis, and Vascular Biology 29 (4):480–7. doi: 10.1161/atvbaha.108.181925.
   PubMed Web of Science ®Google Scholar
• Lee, S. H., J. H. Lee, T. Asahara, Y. S. Kim, H. C. Jeong, Y. Ahn, J. S. Jung, and S.-M. Kwon. 2014. Genistein promotes endothelial colony-forming cell (ECFC) bioactivities and cardiac regeneration in myocardial infarction. PLoS One 9 (5):e96155. doi: 10.1371/journal.pone.0096155.
   PubMed Web of Science ®Google Scholar
• Lemaire, V., F. L. Tobin, L. D. Greller, C. R. Cho, and L. J. Suva. 2004. Modeling the interactions between osteoblast and osteoclast activities in bone remodeling. Journal of Theoretical Biology 229 (3):293–309. doi: 10.1016/j.jtbi.2004.03.023.
   PubMed Web of Science ®Google Scholar
• Leu, S. J., S. C. T. Lam, and L. F. Lau. 2002. Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alpha(v)beta(3) and alpha(6)beta(1) in human umbilical vein endothelial cells. The Journal of Biological Chemistry 277 (48):46248–55. doi: 10.1074/jbc.M209288200.
   PubMed Web of Science ®Google Scholar
• Li, C., X. Miao, S. Wang, B. K. Adhikari, X. Wang, J. Sun, Q. Liu, Q. Tong, and Y. Wang. 2018. Novel curcumin C66 that protects diabetes-induced aortic damage was associated with suppressing JNK2 and upregulating Nrf2 expression and function. Oxidative Medicine and Cellular Longevity 2018:5783239. doi: 10.1155/2018/5783239.
   PubMed Web of Science ®Google Scholar
• Li, C., W.-J. Zhang, and B. Frei. 2016. Quercetin inhibits LPS-induced adhesion molecule expression and oxidant production in human aortic endothelial cells by p38-mediated Nrf2 activation and antioxidant enzyme induction. Redox Biology 9:104–13. doi: 10.1016/j.redox.2016.06.006.
   PubMed Web of Science ®Google Scholar
• Li, H., F. Song, L.-R. Duan, J.-J. Sheng, Y.-H. Xie, Q. Yang, Y. Chen, Q.-Q. Dong, B.-L. Zhang, and S.-W. Wang. 2016. Paeonol and danshensu combination attenuates apoptosis in myocardial infarcted rats by inhibiting oxidative stress: Roles of Nrf2/HO-1 and PI3K/Akt pathway. Scientific Reports 6:23693. doi: 10.1038/srep23693.
   PubMed Web of Science ®Google Scholar
• Li, L. R., H. Dong, E. Q. Song, X. Y. Xu, L. C. Liu, and Y. Song. 2014. Nrf2/ARE pathway activation, HO-1 and NQ01 induction by polychlorinated biphenyl quinone is associated with reactive oxygen. species and PI3K/AKT signaling. Chemico-Biological Interactions 209:56–67. doi: 10.1016/j.cbi.2013.12.005.
   PubMed Web of Science ®Google Scholar
• Li, M., Y. Wang, M. W. Li, X. Z. Wu, S. Setrerrahmane, and H. M. Xu. 2021. Integrins as attractive targets for cancer therapeutics. Acta Pharmaceutica Sinica, B 11 (9):2726–37. doi: 10.1016/j.apsb.2021.01.004.
   PubMed Web of Science ®Google Scholar
• Li, W., T. O. Khor, C. Xu, G. Shen, W. S. Jeong, S. Yu, and A. N. Kong. 2008. Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis. Biochemical Pharmacology 76 (11):1485–9. doi: 10.1016/j.bcp.2008.07.017.
   PubMed Web of Science ®Google Scholar
• Lin, B., J. Xu, D. G. Feng, F. Wang, J. X. Wang, and H. Zhao. 2018. DUSP14 knockout accelerates cardiac ischemia reperfusion (IR) injury through activating NF-κB and MAPKs signaling pathways modulated by ROS generation. Biochemical and Biophysical Research Communications 501 (1):24–32. doi: 10.1016/j.bbrc.2018.04.101.
   PubMed Web of Science ®Google Scholar
• Lin, C.-M., H. Chang, B.-W. Wang, and K.-G. Shyu. 2016. Suppressive effect of epigallocatechin-3-O-gallate on endoglin molecular regulation in myocardial fibrosis in vitro and in vivo. Journal of Cellular and Molecular Medicine 20 (11):2045–55. doi: 10.1111/jcmm.12895.
   PubMed Web of Science ®Google Scholar
• Lin, M. S., X. H. Zhai, G. Z. Wang, X. F. Tian, D. Y. Gao, L. Shi, H. Wu, Q. Fan, J. Y. Peng, K. X. Liu, et al. 2015. Salvianolic acid B protects against acetaminophen hepatotoxicity by inducing Nrf2 and phase II detoxification gene expression via activation of the PI3K and PKC signaling pathways. Journal of Pharmacological Sciences 127 (2):203–10. doi: 10.1016/j.jphs.2014.12.010.
   PubMed Web of Science ®Google Scholar
• Lin, Y. N., M. Jiang, W. J. Chen, T. J. Zhao, and Y. F. Wei. 2019. Cancer and ER stress: Mutual crosstalk between autophagy, oxidative stress and inflammatory response. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 118:109249. doi: 10.1016/j.biopha.2019.109249.
   PubMed Web of Science ®Google Scholar
• Liu, F., Q. Hu, B. Li, A. Manaenko, Y. Chen, J. Tang, Z. Guo, J. Tang, and J. H. Zhang. 2014. Recombinant milk fat globule-EGF factor-8 reduces oxidative stress via integrin beta 3/nuclear factor erythroid 2-related factor 2/heme oxygenase pathway in subarachnoid hemorrhage rats. Stroke 45 (12):3691–7. doi: 10.1161/strokeaha.114.006635.
   PubMed Web of Science ®Google Scholar
• Liu, G., W. Xie, A.-D. He, X.-W. Da, M.-L. Liang, G.-q. Yao, J.-Z. Xiang, C.-j. Gao, and Z.-Y. Ming. 2016. Antiplatelet activity of chrysin via inhibiting platelet alpha IIb beta 3-mediated signaling pathway. Molecular Nutrition & Food Research 60 (9):1984–93. doi: 10.1002/mnfr.201500801.
   PubMed Web of Science ®Google Scholar
• Liu, H., X. B. Jing, A. Q. Dong, B. B. Bai, and H. Y. Wang. 2017. Overexpression of TIMP3 protects against cardiac ischemia/reperfusion injury by inhibiting myocardial apoptosis through ROS/MAPKS pathway. Cellular Physiology and Biochemistry 44 (3):1011–23. doi: 10.1159/000485401.
   PubMed Web of Science ®Google Scholar
• Liu, J., J. Quan, J. Feng, Q. Zhang, Y. Xu, J. Liu, W. Huang, J. Liu, and L. Tian. 2016. High glucose regulates LN expression in human liver sinusoidal endothelial cells through ROS/integrin alpha v beta 3 pathway. Environmental Toxicology and Pharmacology 42:231–6. doi: 10.1016/j.etap.2016.01.021.
   PubMed Web of Science ®Google Scholar
• Liu, P.-L., J.-T. Liu, H.-F. Kuo, I.-W. Chong, and C.-C. Hsieh. 2014. Epigallocatechin gallate attenuates proliferation and oxidative stress in human vascular smooth muscle cells induced by interleukin-1 beta via heme oxygenase-1. Mediators of Inflammation 2014:523684. doi: 10.1155/2014/523684.
   PubMed Web of Science ®Google Scholar
• Lo, H.-M., C.-F. Hung, Y.-Y. Huang, and W.-B. Wu. 2007. Tea polyphenols inhibit rat vascular smooth muscle cell adhesion and migration on collagen and laminin via interference with cell-ECM interaction. Journal of Biomedical Science 14 (5):637–45. doi: 10.1007/s11373-007-9170-6.
   PubMed Web of Science ®Google Scholar
• Long, R., T. Li, L. Wu, and S. Shi. 2020. Synthesis of CdTe quantum dots-based imprinting fluorescent nanosensor for highly specific and sensitive determination of caffeic acid in apple juices. eFood 1 (2):165–72. doi: 10.2991/efood.k.190802.003.
   Google Scholar
• Longmate, W., and C. M. DiPersio. 2017. Beyond adhesion: Emerging roles for integrins in control of the tumor microenvironment. F1000Research 6:1612. doi: 10.12688/f1000research.11877.1.
   PubMedGoogle Scholar
• Lu, Y., Q. Li, Y.-Y. Liu, K. Sun, J.-Y. Fan, C.-S. Wang, and J.-Y. Han. 2015. Inhibitory effect of caffeic acid on ADP-induced thrombus formation and platelet activation involves mitogen-activated protein kinases. Scientific Reports 5:13824. doi: 10.1038/srep13824.
   PubMed Web of Science ®Google Scholar
• Ma, Y., X. Gong, Y. L. Mo, and S. Z. Wu. 2016. Polydatin inhibits the oxidative stress-induced proliferation of vascular smooth muscle cells by activating the eNOS/SIRT1 pathway. International Journal of Molecular Medicine 37 (6):1652–60. doi: 10.3892/ijmm.2016.2554.
   PubMed Web of Science ®Google Scholar
• Matziouridou, C., S. D. C. Rocha, O. A. Haabeth, K. Rudi, H. Carlsen, and A. Kielland. 2018. iNOS- and NOX1-dependent ROS production maintains bacterial homeostasis in the ileum of mice. Mucosal Immunology 11 (3):774–84. doi: 10.1038/mi.2017.106.
   PubMed Web of Science ®Google Scholar
• mbaran, T. F., and A. Nordström. 2021. Medical and pharmacokinetic effects of nanopolyphenols: A systematic review of clinical trials. Food Frontiers 2 (2):140–52. doi: 10.1002/fft2.72.
   Google Scholar
• Menon, B., M. Singh, R. S. Ross, J. N. Johnson, and K. Singh. 2006. β-Adrenergic receptor-stimulated apoptosis in adult cardiac myocytes involves MMP-2-mediated disruption of β1 integrin signaling and mitochondrial pathway. American Journal of Physiology. Cell Physiology 290 (1):C254–C261. doi: 10.1152/ajpcell.00235.2005.
   PubMed Web of Science ®Google Scholar
• Menon, B., M. Singh, and K. Singh. 2005. Matrix metalloproteinases mediate beta-adrenergic receptor-stimulated apoptosis in adult rat ventricular myocytes. American Journal of Physiology. Cell Physiology 289 (1):C168–176. doi: 10.1152/ajpcell.00606.2004.
   PubMed Web of Science ®Google Scholar
• Mezu-Ndubuisi, O. J., and A. Maheshwari. 2021. The role of integrins in inflammation and angiogenesis. Pediatric Research 89 (7):1619–26. doi: 10.1038/s41390-020-01177-9.
   PubMed Web of Science ®Google Scholar
• Miller, M. R. 2020. Oxidative stress and the cardiovascular effects of air pollution. Free Radical Biology & Medicine 151:69–87. doi: 10.1016/j.freeradbiomed.2020.01.004.
   PubMed Web of Science ®Google Scholar
• Moghaddam, R. H., Z. Samimi, S. Z. Moradi, P. J. Little, S. Xu, and M. H. Farzaei. 2020. Naringenin and naringin in cardiovascular disease prevention: A preclinical review. European Journal of Pharmacology 887:173535. doi: 10.1016/j.ejphar.2020.173535.
   PubMed Web of Science ®Google Scholar
• Mohammadi, M., A. Hajhossein Talasaz, and M. Alidoosti. 2016. Preventive effect of l-carnitine and its derivatives on endothelial dysfunction and platelet aggregation. Clinical Nutrition ESPEN 15:1–10. doi: 10.1016/j.clnesp.2016.06.009.
   PubMedGoogle Scholar
• Moradi, S. Z., S. Momtaz, Z. Bayrami, M. H. Farzaei, and M. Abdollahi. 2020. Nanoformulations of herbal extracts in treatment of neurodegenerative disorders. Frontiers in Bioengineering and Biotechnology 8:238. doi: 10.3389/fbioe.2020.00238.
   PubMed Web of Science ®Google Scholar
• Morawietz, H. 2018. Cardiovascular protection by Nox4. Cardiovascular Research 114 (3):353–5. doi: 10.1093/cvr/cvx252.
   PubMed Web of Science ®Google Scholar
• Murphy, J. M., K. Jeong, Y. A. R. Rodriguez, J.-H. Kim, E.-Y. E. Ahn, and S.-T. S. Lim. 2019. FAK and Pyk2 activity promote TNF-α and IL-1β-mediated pro-inflammatory gene expression and vascular inflammation. Scientific Reports 9 (1):7617. doi: 10.1038/s41598-019-44098-2.
   PubMedGoogle Scholar
• Nam, G. S., H.-J. Park, and K.-S. Nam. 2020. The antithrombotic effect of caffeic acid is associated with a cAMPdependent pathway and clot retraction in human platelets. Thrombosis Research 195:87–94. doi: 10.1016/j.thromres.2020.07.024.
   PubMed Web of Science ®Google Scholar
• Naseri, R., F. Farzaei, S. Fakhri, F. F. El-Senduny, M. Altouhamy, R. Bahramsoltani, F. Ebrahimi, R. Rahimi, and M. H. Farzaei. 2019. Polyphenols for diabetes associated neuropathy: Pharmacological targets and clinical perspective. Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences 27 (2):781–98. doi: 10.1007/s40199-019-00289-w.
   PubMed Web of Science ®Google Scholar
• Nashibi, M., P. Sezari, K. Mottaghi, S. Yeganeh-Khah, and F. Safari. 2019. Antioxidative effects of isoflurane and propofol on serum levels of catalase, glutathione and superoxide dismutase in craniotomy for supratentorial tumor. Journal of Cellular and Molecular Anesthesia 4:33–40. doi: 10.22037/jcma.v4i2.26827.
   Google Scholar
• Navarro-Nunez, L., M. L. Lozano, C. Martinez, V. Vicente, and J. Rivera. 2010. Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases. Fitoterapia 81 (2):75–80. doi: 10.1016/j.fitote.2009.08.006.
   PubMed Web of Science ®Google Scholar
• Nolte, M. A., and C. Margadant. 2020. Activation and suppression of hematopoietic integrins in hemostasis and immunity. Blood 135 (1):7–16. doi: 10.1182/blood.2019003336.
   PubMed Web of Science ®Google Scholar
• Oh, W. J., M. Endale, S. C. Park, J. Y. Cho, and M. H. Rhee. 2012. Dual roles of quercetin in platelets: Phosphoinositide-3-Kinase and MAP Kinases inhibition, and cAMP-dependent vasodilator-stimulated phosphoprotein stimulation. Evidence-Based Complementary and Alternative Medicine: eCAM 2012:485262. doi: 10.1155/2012/485262.
   PubMed Web of Science ®Google Scholar
• Pan, X. Q., D. D. Yan, D. Wang, X. Wu, W. Y. Zhao, Q. Lu, and H. Yan. 2017. Mitochondrion-mediated apoptosis induced by acrylamide is regulated by a balance between Nrf2 antioxidant and MAPK signaling pathways in PC12 cells. Molecular Neurobiology 54 (6):4781–94. doi: 10.1007/s12035-016-0021-1.
   PubMed Web of Science ®Google Scholar
• Panchal, S. K., H. Poudyal, and L. Brown. 2012. Quercetin ameliorates cardiovascular, hepatic, and metabolic changes in diet-induced metabolic syndrome in rats. The Journal of Nutrition 142 (6):1026–32. doi: 10.3945/jn.111.157263.
   PubMed Web of Science ®Google Scholar
• Park, J. H., H. J. Ku, J. K. Kim, J.-W. Park, and J. H. Lee. 2018. Amelioration of high fructose-induced cardiac hypertrophy by naringin. Scientific Reports 8 (1):9464. doi: 10.1038/s41598-018-27788-1.
   PubMed Web of Science ®Google Scholar
• Park, S., S. Ranjbarvaziri, P. Zhao, and R. Ardehali. 2020. Cardiac fibrosis is associated with decreased circulating levels of full-length CILP in heart failure. JACC. Basic to Translational Science 5 (5):432–43. doi: 10.1016/j.jacbts.2020.01.016.
   PubMedGoogle Scholar
• Pasarin, M., V. La Mura, J. Gracia-Sancho, H. Garcia-Caldero, A. Rodriguez-Vilarrupla, J. Carlos Garcia-Pagan, J. Bosch, and J. G. Abraldes. 2012. Sinusoidal endothelial dysfunction precedes inflammation and fibrosis in a model of NAFLD. PLoS One 7 (4):e32785. doi: 10.1371/journal.pone.0032785.
   PubMed Web of Science ®Google Scholar
• Prabhakaran, D., P. Jeemon, and A. Roy. 2016. Cardiovascular diseases in India: Current epidemiology and future directions. Circulation 133 (16):1605–20. doi: 10.1161/circulationaha.114.008729.
   PubMed Web of Science ®Google Scholar
• Prabhu, S., R. Sharma, and K. Peter. 2011. Platelets in the pathogenesis of vascular disease and their role as a therapeutic target. In Mechanisms of vascular disease: A reference book for vascular specialists, ed. R. Fitridge and M. Thompson. South Australia: University of Adelaide Press.
   Google Scholar
• Prasain, J. K., and S. Barnes. 2020. Cranberry polyphenols-gut microbiota interactions and potential health benefits: An updated review. Food Frontiers 1 (4):459–64. doi: 10.1002/fft2.56.
   Google Scholar
• Prasain, J. K., S. Barnes, and J. M. Wyss. 2021. Kudzu isoflavone C-glycosides: Analysis, biological activities, and metabolism. Food Frontiers 2 (3):383–9. doi: 10.1002/fft2.105.
   Google Scholar
• Qin, L., Y.-B. Yang, Q.-H. Tuo, B.-Y. Zhu, L.-X. Chen, L. Zhang, and D.-F. Liao. 2009. Effects and underlying mechanisms of curcumin on the proliferation of vascular smooth muscle cells induced by Chol:M beta CD. Biochemical and Biophysical Research Communications 379 (2):277–82. doi: 10.1016/j.bbrc.2008.12.038.
   PubMed Web of Science ®Google Scholar
• Radosinska, J., M. Barancik, and N. Vrbjar. 2017. Heart failure and role of circulating MMP-2 and MMP-9. Panminerva Medica 59 (3):241–53. doi: 10.23736/s0031-0808.17.03321-3.
   PubMed Web of Science ®Google Scholar
• Ravikumar, R., G. Flora, J. W. Geddes, B. Hennig, and M. Toborek. 2004. Nicotine attenuates oxidative stress, activation of redox-regulated transcription factors and induction of proinflammatory genes in compressive spinal cord trauma. Brain Research. Molecular Brain Research 124 (2):188–98. doi: 10.1016/j.molbrainres.2004.02.018.
   PubMedGoogle Scholar
• Ravishankar, D., D. A. I. Albadawi, V. Chaggar, P. H. Patra, H. F. Williams, M. Salamah, R. Vaiyapuri, P. R. Dash, K. Patel, K. A. Watson, et al. 2019. Isorhapontigenin, a resveratrol analogue selectively inhibits ADP-stimulated platelet activation. European Journal of Pharmacology 862:172627. doi: 10.1016/j.ejphar.2019.172627.
   PubMed Web of Science ®Google Scholar
• Ren, J., N. Zhang, H. Liao, S. Chen, L. Xu, J. Li, Z. Yang, W. Deng, and Q. Tang. 2017. Caffeic acid phenethyl ester attenuates pathological cardiac hypertrophy by regulation of MEK/ERK signaling pathway in vivo and vitro. Life Sciences 181:53–61. doi: 10.1016/j.lfs.2017.04.016.
   PubMed Web of Science ®Google Scholar
• Roth, G. A., C. Johnson, A. Abajobir, F. Abd-Allah, S. F. Abera, G. Abyu, M. Ahmed, B. Aksut, T. Alam, K. Alam, et al. 2017. Global, regional, and national burden of cardiovascular diseases for 10 causes. Journal of the American College of Cardiology 70 (1):1–25. doi: 10.1016/j.jacc.2017.04.052.
   PubMed Web of Science ®Google Scholar
• Rozentsvit, A., K. Vinokur, S. Samuel, Y. Li, A. M. Gerdes, and M. A. Carrillo-Sepulveda. 2017. Ellagic acid reduces high glucose-induced vascular oxidative stress through ERK1/2/NOX4 signaling pathway. Cellular Physiology and Biochemistry 44 (3):1174–87. doi: 10.1159/000485448.
   PubMedGoogle Scholar
• Ruotsalainen, A. K., M. Inkala, M. E. Partanen, J. P. Lappalainen, E. Kansanen, P. I. Makinen, S. E. Heinonen, H. M. Laitinen, J. Heikkila, T. Vatanen, et al. 2013. The absence of macrophage Nrf2 promotes early atherogenesis. Cardiovascular Research 98 (1):107–15. doi: 10.1093/cvr/cvt008.
   PubMed Web of Science ®Google Scholar
• Sallam, N., and I. Laher. 2016. Exercise modulates oxidative stress and inflammation in aging and cardiovascular diseases. Oxidative Medicine and Cellular Longevity 2016:7239639. doi: 10.1155/2016/7239639.
   PubMed Web of Science ®Google Scholar
• Samarel, A. M. 2005. Costameres, focal adhesions, and cardiomyocyte mechanotransduction. American Journal of Physiology. Heart and Circulatory Physiology 289 (6):H2291–H2301. doi: 10.1152/ajpheart.00749.2005.
   PubMed Web of Science ®Google Scholar
• Schaff, M., N. Receveur, C. Bourdon, P. Ohlmann, F. Lanza, C. Gachet, and P. H. Mangin. 2012. beta-arrestin-1 participates in thrombosis and regulates integrin alpha(IIB)beta(3) signalling without affecting P2Y receptors desensitisation and function. Thrombosis and Haemostasis 107 (04):735–48. doi: 10.1160/TH11-06-0430.
   PubMedGoogle Scholar
• Schell, C., and T. B. Huber. 2012. New players in the pathogenesis of focal segmental glomerulosclerosis. Nephrology, Dialysis, Transplantation 27 (9):3406–12. doi: 10.1093/ndt/gfs273.
   PubMed Web of Science ®Google Scholar
• Schluterman, M. K., S. L. Chapman, G. Korpanty, K. Ozumi, T. Fukai, H. Yanagisawa, and R. A. Brekken. 2010. Loss of fibulin-5 binding to beta 1 integrins inhibits tumor growth by increasing the level of ROS. Disease Models & Mechanisms 3 (5–6):333–42. doi: 10.1242/dmm.003707.
   PubMed Web of Science ®Google Scholar
• Shahidi, M., F. Parhizkary, R. Sharifi, A. Ghotaslou, and M. Barati. 2020. Effects of resveratrol on coagulative, fibrinolytic, and inflammatory marker expression and secretion by endothelial cells (human umbilical vein endothelial cells). Blood Coagulation & Fibrinolysis 31 (3):207–12. doi: 10.1097/mbc.0000000000000900.
   PubMed Web of Science ®Google Scholar
• Sharma, A., M. Parikh, H. Shah, and T. Gandhi. 2020. Modulation of Nrf2 by quercetin in doxorubicin-treated rats. Heliyon 6 (4):e03803. doi: 10.1016/j.heliyon.2020.e03803.
   PubMed Web of Science ®Google Scholar
• Shen, Y., M. Gao, Y. Ma, H. Yu, F.-Z. Cui, H. Gregersen, Q. Yu, G. Wang, and X. Liu. 2015. Effect of surface chemistry on the integrin induced pathway in regulating vascular endothelial cells migration. Colloids and Surfaces, B: Biointerfaces 126:188–97. doi: 10.1016/j.colsurfb.2014.12.019.
   PubMed Web of Science ®Google Scholar
• Shen, Y., N. C. Ward, J. M. Hodgson, I. B. Puddey, Y. Wang, D. Zhang, G. J. Maghzal, R. Stocker, and K. D. Croft. 2013. Dietary quercetin attenuates oxidant-induced endothelial dysfunction and atherosclerosis in apolipoprotein E knockout mice fed a high-fat diet: A critical role for heme oxygenase-1. Free Radical Biology and Medicine 65:908–15. doi: 10.1016/j.freeradbiomed.2013.08.185.
   PubMed Web of Science ®Google Scholar
• Sheng, Z.-G., W. Huang, Y.-X. Liu, Y. Yuan, and B.-Z. Zhu. 2013. Ofloxacin induces apoptosis via beta 1 integrin-EGFR-Rac1-Nox2 pathway in microencapsulated chondrocytes. Toxicology and Applied Pharmacology 267 (1):74–87. doi: 10.1016/j.taap.2012.12.015.
   PubMed Web of Science ®Google Scholar
• Shimojo, N., R. Hashizume, K. Kanayama, M. Hara, Y. Suzuki, T. Nishioka, M. Hiroe, T. Yoshida, and K. Imanaka-Yoshida. 2015. Tenascin-C may accelerate cardiac fibrosis by activating macrophages via the integrin αVβ3/nuclear factor-κB/interleukin-6 axis. Hypertension (Dallas, TX: 1979) 66 (4):757–66. doi: 10.1161/hypertensionaha.115.06004.
   PubMed Web of Science ®Google Scholar
• Smyrnias, I., X. H. Zhang, M. Zhang, T. V. A. Murray, R. P. Brandes, K. Schroder, A. C. Brewer, and A. M. Shah. 2015. Nicotinamide adenine dinucleotide phosphate oxidase-4-dependent upregulation of nuclear factor erythroid-derived 2-like 2 protects the heart during chronic pressure overload. Hypertension (Dallas, TX: 1979) 65 (3):547–53. doi: 10.1161/hypertensionaha.114.04208.
   PubMed Web of Science ®Google Scholar
• Spickett, C. M., A. Jerlich, O. M. Panasenko, J. Arnhold, A. R. Pitt, T. Stelmaszyńska, and R. J. Schaur. 2000. The reactions of hypochlorous acid, the reactive oxygen species produced by myeloperoxidase, with lipids. Acta Biochimica Polonica 47 (4):889–99. doi: 10.18388/abp.2000_3944.
   PubMed Web of Science ®Google Scholar
• Stainer, A. R., P. Sasikumar, A. P. Bye, A. J. Unsworth, L. M. Holbrook, M. Tindall, J. A. Lovegrove, and J. M. Gibbins. 2019. The metabolites of the dietary flavonoid quercetin possess potent antithrombotic activity, and interact with aspirin to enhance antiplatelet effects. TH Open 3 (3):e244–e258. doi: 10.1055/s-0039-1694028.
   PubMedGoogle Scholar
• Sun, C., C. Zhao, E. C. Guven, P. Paoli, J. Simal-Gandara, K. M. Ramkumar, S. Wang, F. Buleu, A. Pah, V. Turi, et al. 2020a. Dietary polyphenols as antidiabetic agents: Advances and opportunities. Food Frontiers 1 (1):18–44. doi: 10.1002/fft2.15.
   Google Scholar
• Sun, Q., Z. Ye, Y. Qin, G. Fan, S. Ji, Q. Zhuo, W. Xu, W. Liu, Q. Hu, M. Liu, et al. 2020b. Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis. Oncogene 39 (42):6572–88. doi: 10.1038/s41388-020-01452-3.
   PubMed Web of Science ®Google Scholar
• Tavakol, S., S. Zare, E. Hoveizi, B. Tavakol, and S. M. Rezayat. 2019. The impact of the particle size of curcumin nanocarriers and the ethanol on beta_1-integrin overexpression in fibroblasts: A regenerative pharmaceutical approach in skin repair and anti-aging formulations. Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences 27 (1):159–68. doi: 10.1007/s40199-019-00258-3.
   PubMed Web of Science ®Google Scholar
• Teng, H., H. T. Deng, Y. J. He, Q. Y. Lv, and L. Chen. 2021. The role of dietary flavonoids for modulation of ATP binding cassette transporter mediated multidrug resistance. eFood 2 (5):234–46. doi: 10.53365/efood.k/144604.
   Google Scholar
• Terasaki, F., H. Okamoto, K. Onishi, A. Sato, H. Shimomura, B. Tsukada, K. Imanaka-Yoshida, M. Hiroe, T. Yoshida, Y. Kitaura, et al. 2007. Higher serum Tenascin-C levels reflect the severity of heart failure, left ventricular dysfunction and remodeling in patients with dilated cardiomyopathy. Circulation Journal 71 (3):327–30. doi: 10.1253/circj.71.327.
   PubMed Web of Science ®Google Scholar
• Thakur, S., L. Li, and S. Gupta. 2014. NF-κB-mediated integrin-linked kinase regulation in angiotensin II-induced pro-fibrotic process in cardiac fibroblasts. Life Sciences 107 (1–2):68–75. doi: 10.1016/j.lfs.2014.04.030.
   PubMed Web of Science ®Google Scholar
• Tian, R., R. Peng, Z. Y. Yang, Y. Y. Peng, and N. H. Lu. 2020. Supplementation of dietary nitrate attenuated oxidative stress and endothelial dysfunction in diabetic vasculature through inhibition of NADPH oxidase. Nitric Oxide: Biology and Chemistry 96:54–63. doi: 10.1016/j.niox.2020.01.007.
   PubMed Web of Science ®Google Scholar
• Todorovic, V., C. C. Chen, N. Hay, and L. F. Lau. 2005. The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts. The Journal of Cell Biology 171 (3):559–68. doi: 10.1083/jcb.200504015.
   PubMed Web of Science ®Google Scholar
• Torramade-Moix, S., M. Palomo, M. Vera, D. Jerez, A. B. Moreno-Castano, M. U. Zafar, J. Rovira, F. Diekmann, J. C. Garcia-Pagan, G. Escolar, et al. 2021. Apixaban downregulates endothelial inflammatory and prothrombotic phenotype in an in vitro model of endothelial dysfunction in uremia. Cardiovascular Drugs and Therapy 35 (3):521–32. doi: 10.1007/s10557-020-07010-z.
   PubMed Web of Science ®Google Scholar
• Touyz, R. M., X. H. Wu, G. He, S. Salomon, and E. L. Schiffrin. 2002. Increased angiotensin II-mediated Src signaling via epidermal growth factor receptor transactivation is associated with decreased c-terminal Src kinase activity in vascular smooth muscle cells from spontaneously hypertensive rats. Hypertension 39 (2):479–85. doi: 10.1161/hy02t2.102909.
   PubMed Web of Science ®Google Scholar
• Townsend, P. A., T. M. Scarabelli, E. Pasini, G. Gitti, M. Menegazzi, H. Suzuki, R. A. Knight, D. S. Latchman, and A. Stephanou. 2004. Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis. Faseb Journal 18 (11):1612. +. doi: 10.1096/fj.04-1716fje.
   PubMed Web of Science ®Google Scholar
• Tsai, C. Y., C. C. Wang, T. Y. Lai, H. N. Tsu, C. H. Wang, H. Y. Liang, and W. W. Kuo. 2013. Antioxidant effects of diallyl trisulfide on high glucose-induced apoptosis are mediated by the PI3K/Akt-dependent activation of Nrf2 in cardiomyocytes. International Journal of Cardiology 168 (2):1286–97. doi: 10.1016/j.ijcard.2012.12.004.
   PubMed Web of Science ®Google Scholar
• Tsuchihashi, S.-i., R. W. Busuttil, and J. W. Kupiec-Weglinski. 2005. Heme oxygenase system. In Signaling pathways in liver diseases, ed. J.-F. Dufour, P.-A. Clavien, C. Trautwein, and R. Graf (pp. 291–8). Berlin, Heidelberg: Springer.
   Google Scholar
• Tu, W. J., H. Wang, S. Li, Q. Liu, and H. Sha. 2019. The anti-inflammatory and anti-oxidant mechanisms of the Keap1/Nrf2/ARE signaling pathway in chronic diseases. Aging and Disease 10 (3):637–51. doi: 10.14336/ad.2018.0513.
   PubMed Web of Science ®Google Scholar
• Turpaev, K. T. 2013. Keap1-Nrf2 signaling pathway: Mechanisms of regulation and role in protection of cells against toxicity caused by xenobiotics and electrophiles. Biochemistry. Biokhimiia 78 (2):111–26. doi: 10.1134/s0006297913020016.
   PubMed Web of Science ®Google Scholar
• Ungvari, Z., Z. Bagi, A. Feher, F. A. Recchia, W. E. Sonntag, K. Pearson, R. de Cabo, and A. Csiszar. 2010. Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2. American Journal of Physiology. Heart and Circulatory Physiology 299 (1):H18–H24. doi: 10.1152/ajpheart.00260.2010.
   PubMed Web of Science ®Google Scholar
• Victor, V. M., S. Rovira-Llopis, C. Bañuls, N. Diaz-Morales, A. Martinez de Marañon, C. Rios-Navarro, A. Alvarez, M. Gomez, M. Rocha, and A. Hernández-Mijares. 2016. Insulin resistance in PCOS patients enhances oxidative stress and leukocyte adhesion: Role of myeloperoxidase. PLoS One 11 (3):e0151960. doi: 10.1371/journal.pone.0151960.
   PubMed Web of Science ®Google Scholar
• Voltan, R., P. Secchiero, F. Casciano, D. Milani, G. Zauli, and V. Tisato. 2016. Redox signaling and oxidative stress: Cross talk with TNF-related apoptosis inducing ligand activity. The International Journal of Biochemistry & Cell Biology 81 (Pt B):364–74. doi: 10.1016/j.biocel.2016.09.019.
   PubMedGoogle Scholar
• Wafi, A. M., J. Hong, T. L. Rudebush, L. Yu, B. Hackfort, H. Wang, H. D. Schultz, I. H. Zucker, and L. Gao. 2019. Curcumin improves exercise performance of mice with coronary artery ligation-induced HFrEF: Nrf2 and antioxidant mechanisms in skeletal muscle. Journal of Applied Physiology (Bethesda, MD: 1985) 126 (2):477–86. doi: 10.1152/japplphysiol.00654.2018.
   PubMed Web of Science ®Google Scholar
• Wang, C., H. Yang, and J. Li. 2021. Combination of microwave, ultrasonic, enzyme assisted method for curcumin species extraction from Turmeric (Curcuma Longa L.) and evaluation of their antioxidant activity. eFood 2 (2):73–80. doi: 10.2991/efood.k.210329.001.
   Google Scholar
• Wang, G., X. Song, L. Zhao, Z. Li, and B. Liu. 2018. Resveratrol prevents diabetic cardiomyopathy by increasing Nrf2 expression and transcriptional activity. BioMed Research International 2018:2150218. doi: 10.1155/2018/2150218.
   PubMed Web of Science ®Google Scholar
• Wang, H., X. Chen, Y. Su, P. Paueksakon, W. Hu, M.-Z. Zhang, R. C. Harris, T. S. Blackwell, R. Zent, and A. Pozzi. 2015. p47(phox) contributes to albuminuria and kidney fibrosis in mice. Kidney International 87 (5):948–62. doi: 10.1038/ki.2014.386.
   PubMed Web of Science ®Google Scholar
• Wang, S. B., J. Y. Jang, Y. H. Chae, J. H. Min, J. Y. Baek, M. Kim, Y. Park, G. S. Hwang, J.-S. Ryu, and T.-S. Chang. 2015. Kaempferol suppresses collagen-induced platelet activation by inhibiting NADPH oxidase and protecting SHP-2 from oxidative inactivation. Free Radical Biology & Medicine 83:41–53. doi: 10.1016/j.freeradbiomed.2015.01.018.
   PubMed Web of Science ®Google Scholar
• Wolf, D., N. Anto-Michel, H. Blankenbach, A. Wiedemann, K. Buscher, J. D. Hohmann, B. Lim, M. Bauml, A. Marki, M. Mauler, et al. 2018. A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense. Nature Communications 9 (1):525. doi: 10.1038/s41467-018-02896-8.
   PubMedGoogle Scholar
• Wu, H., G.-N. Li, J. Xie, R. Li, Q.-H. Chen, J.-Z. Chen, Z.-H. Wei, L.-N. Kang, and B. Xu. 2016. Resveratrol ameliorates myocardial fibrosis by inhibiting ROS/ERK/TGF-beta/periostin pathway in STZ-induced diabetic mice. BMC Cardiovascular Disorders 16:5. doi: 10.1186/s12872-015-0169-z.
   PubMed Web of Science ®Google Scholar
• Wyssenbach, A., T. Quintela, F. Llavero, J. L. Zugaza, C. Matute, and E. Alberdi. 2016. Amyloid beta-induced astrogliosis is mediated by beta 1-integrin via NADPH oxidase 2 in Alzheimer’s disease. Aging Cell 15 (6):1140–52. doi: 10.1111/acel.12521.
   PubMed Web of Science ®Google Scholar
• Xiao, H.-B., X.-Y. Lu, Z.-K. Liu, and Z.-F. Luo. 2016. Kaempferol inhibits the production of ROS to modulate OPN-alpha(v)beta(3) integrin pathway in HUVECs. Journal of Physiology and Biochemistry 72 (2):303–13. doi: 10.1007/s13105-016-0479-3.
   PubMed Web of Science ®Google Scholar
• Xing, L. Y., Y. Xue, Y. L. Yang, P. Wu, C. C. L. Wong, H. J. Wang, Z. J. Song, D. W. Shi, C. Y. Tong, C. L. Yao, et al. 2020. TMT-based quantitative proteomic analysis identification of integrin alpha 3 and integrin alpha 5 as novel biomarkers in pathogenesis of acute aortic dissection. BioMed Research International 2020:1–12. doi: 10.1155/2020/1068402.
   Web of Science ®Google Scholar
• Xu, C.-S., Z.-F. Wang, X.-D. Huang, L.-M. Dai, C.-J. Cao, and Z.-Q. Li. 2015. Involvement of ROS-alpha v beta 3 integrin-FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia. Journal of Translational Medicine 13:95. doi: 10.1186/s12967-015-0454-8.
   PubMed Web of Science ®Google Scholar
• Xu, H., H. Lu, X. Zhu, W. Wang, Z. Zhang, H. Fu, S. Ma, Y. Luo, and J. Fu. 2018. Inhibitory effects of luteolin-4’-O-beta-D-glucopyranoside on P2Y(12) and thromboxane A(2) receptor-mediated amplification of platelet activation in vitro. International Journal of Molecular Medicine 42 (1):615–24. doi: 10.3892/ijmm.2018.3634.
   PubMed Web of Science ®Google Scholar
• Xu, X. H., G. L. Li, B. A. Wang, Y. Qin, S. R. Bai, J. Rong, T. Deng, and Q. Li. 2015. Diallyl trisufide protects against oxygen glucose deprivation-induced apoptosis by scavenging free radicals via the PI3K/Akt-mediated Nrf2/HO-1 signaling pathway in B35 neural cells. Brain Research 1614:38–50. doi: 10.1016/j.brainres.2015.04.014.
   PubMed Web of Science ®Google Scholar
• Xu, X. R., N. Carrim, M. A. D. Neves, T. McKeown, T. W. Stratton, R. M. P. Coelho, X. Lei, P. Chen, J. Xu, X. Dai, et al. 2016. Platelets and platelet adhesion molecules: Novel mechanisms of thrombosis and anti-thrombotic therapies. Thrombosis Journal 14 (Suppl 1):29. doi: 10.1186/s12959-016-0100-6.
   PubMedGoogle Scholar
• Ya, F., X. R. Xu, Y. Shi, R. C. Gallant, F. Song, X. Zuo, Y. Zhao, Z. Tian, C. Zhang, X. Xu, et al. 2019. Coenzyme Q10 upregulates platelet cAMP/PKA pathway and attenuates integrin αIIbβ3 signaling and thrombus growth. Molecular Nutrition & Food Research 63 (23):e1900662. doi: 10.1002/mnfr.201900662.
   PubMed Web of Science ®Google Scholar
• Yang, S. B., Y. Zheng, and X. H. Hou. 2019. Lipoxin A4 restores oxidative stress-induced vascular endothelial cell injury and thrombosis-related factor expression by its receptor-mediated activation of Nrf2-HO-1 axis. Cellular Signalling 60:146–53. doi: 10.1016/j.cellsig.2019.05.002.
   PubMed Web of Science ®Google Scholar
• Yang, Y., Z. Shi, A. Reheman, J. W. Jin, C. Li, Y. Wang, M. C. Andrews, P. Chen, G. Zhu, W. Ling, et al. 2012. Plant food delphinidin-3-glucoside significantly inhibits platelet activation and thrombosis: Novel protective roles against cardiovascular diseases. PLoS One 7 (5):e37323. doi: 10.1371/journal.pone.0037323.
   PubMed Web of Science ®Google Scholar
• Yang, Y. J., T. Tian, Y. P. Wang, Z. Li, K. Xing, and G. Tian. 2019. SIRT6 protects vascular endothelial cells from angiotensin II-induced apoptosis and oxidative stress by promoting the activation of Nrf2/ARE signaling. European Journal of Pharmacology 859:172516. doi: 10.1016/j.ejphar.2019.172516.
   PubMed Web of Science ®Google Scholar
• Yao, Y., Y. Chen, R. Adili, T. McKeown, P. Chen, G. Zhu, D. Li, W. Ling, H. Ni, and Y. Yang. 2017. Plant-based food cyanidin-3-glucoside modulates human platelet glycoprotein VI signaling and inhibits platelet activation and thrombus formation. The Journal of Nutrition 147 (10):1917–25. doi: 10.3945/jn.116.245944.
   PubMed Web of Science ®Google Scholar
• Yoshida, L. S., and S. Tsunawaki. 2008. Expression of NADPH oxidases and enhanced H(2)O(2)-generating activity in human coronary artery endothelial cells upon induction with tumor necrosis factor-alpha. International Immunopharmacology 8 (10):1377–85. doi: 10.1016/j.intimp.2008.05.004.
   PubMed Web of Science ®Google Scholar
• Yoshida, Y., K. Togi, H. Matsumae, Y. Nakashima, Y. Kojima, H. Yamamoto, K. Ono, T. Nakamura, T. Kita, and M. Tanaka. 2007. CCN1 protects cardiac myocytes from oxidative stress via beta 1 integrin-Akt pathway. Biochemical and Biophysical Research Communications 355 (3):611–8. doi: 10.1016/j.bbrc.2007.01.195.
   PubMed Web of Science ®Google Scholar
• Youn, G. S., K. W. Lee, S. Y. Choi, and J. Park. 2016. Overexpression of HDAC6 induces pro-inflammatory responses by regulating ROS-MAPK-NF-κB/AP-1 signaling pathways in macrophages. Free Radical Biology & Medicine 97:14–23. doi: 10.1016/j.freeradbiomed.2016.05.014.
   PubMed Web of Science ®Google Scholar
• Yu, G., A. H. Rux, P. Ma, K. Bdeir, and B. S. Sachais. 2005. Endothelial expression of E-selectin is induced by the platelet-specific chemokine platelet factor 4 through LRP in an NF-kappaB-dependent manner. Blood 105 (9):3545–51. doi: 10.1182/blood-2004-07-2617.
   PubMed Web of Science ®Google Scholar
• Yu, L.-M., X. Dong, X.-D. Xue, J. Zhang, Z. Li, H.-J. Wu, Z.-L. Yang, Y. Yang, and H.-S. Wang. 2019a. Naringenin improves mitochondrial function and reduces cardiac damage following ischemia-reperfusion injury: The role of the AMPK-SIRT3 signaling pathway. Food & Function 10 (5):2752–65. doi: 10.1039/c9fo00001a.
   PubMed Web of Science ®Google Scholar
• Yu, L.-M., X. Dong, J. Zhang, Z. Li, X.-D. Xue, H.-J. Wu, Z.-L. Yang, Y. Yang, and H.-S. Wang. 2019b. Naringenin attenuates myocardial ischemia-reperfusion injury via cGMP-PKGI alpha signaling and in vivo and in vitro studies. Oxidative Medicine and Cellular Longevity 2019:7670854. doi: 10.1155/2019/7670854.
   PubMed Web of Science ®Google Scholar
• Yu, M. H., T. Y. Yang, H. H. Ho, H. P. Huang, K. C. Chan, and C. J. Wang. 2018. Mulberry polyphenol extract inhibits FAK/Src/PI3K complex and related signaling to regulate the migration in A7r5 cells. Journal of Agricultural and Food Chemistry 66 (15):3860–9. doi: 10.1021/acs.jafc.8b00958.
   PubMed Web of Science ®Google Scholar
• Zhang, H. L., G. Caprioli, H. Hussain, N. P. Khoi Le, M. A. Farag, and J. B. Xiao. 2021. A multifaceted review on dihydromyricetin resources, extraction, bioavailability, biotransformation, bioactivities, and food applications with future perspectives to maximize its value. eFood 2 (4):164–84. doi: 10.53365/efood.k/143518.
   Google Scholar
• Zhang, H. P., F. L. Zheng, J. H. Zhao, D. X. Guo, and X. L. Chen. 2013. Genistein inhibits ox-LDL-induced VCAM-1, ICAM-1 and MCP-1 expression of HUVECs through heme oxygenase-1. Archives of Medical Research 44 (1):13–20. doi: 10.1016/j.arcmed.2012.12.001.
   PubMed Web of Science ®Google Scholar
• Zhang, J., H. Qiu, J. Huang, S. Ding, B. Huang, Q. Wu, and Q. Jiang. 2018. Naringenin exhibits the protective effect on cardiac hypertrophy via EETs-PPARs activation in streptozocin-induced diabetic mice. Biochemical and Biophysical Research Communications 502 (1):55–61. doi: 10.1016/j.bbrc.2018.05.119.
   PubMed Web of Science ®Google Scholar
• Zhang, J. F., X. M. Chen, X. Y. Mu, M. W. Hu, J. Wang, X. J. Huang, and S. P. Nie. 2021. Protective effects of flavonoids isolated from Agrocybe aegirita on dextran sodium sulfate-induced colitis. eFood 2 (6):288–95. doi: 10.53365/efood.k/147240.
   Google Scholar
• Zhang, N., Z. Yang, Y. Yuan, F. Li, Y. Liu, Z. Ma, H. Liao, Z. Bian, Y. Zhang, H. Zhou, et al. 2015. Naringenin attenuates pressure overload-induced cardiac hypertrophy. Experimental and Therapeutic Medicine 10 (6):2206–12. doi: 10.3892/etm.2015.2816.
   PubMed Web of Science ®Google Scholar
• Zhang, W., C. Guo, R. Gao, M. Ge, Y. Zhu, and Z. Zhang. 2013. The protective role of resveratrol against arsenic trioxide-induced cardiotoxicity. Evidence-Based Complementary and Alternative Medicine: eCAM 2013:407839. doi: 10.1155/2013/407839.
   PubMed Web of Science ®Google Scholar
• Zhang, X., C. Hu, N. Zhang, W. Y. Wei, L. L. Li, H. M. Wu, Z. G. Ma, and Q. Z. Tang. 2021. Matrine attenuates pathological cardiac fibrosis via RPS5/p38 in mice. Acta Pharmacologica Sinica 42 (4):573–84. doi: 10.1038/s41401-020-0473-8.
   PubMed Web of Science ®Google Scholar
• Zhang, Y. T., K. A. Ahmad, F. U. Khan, S. M. Yan, A. U. Ihsan, and Q. L. Ding. 2019. Chitosan oligosaccharides prevent doxorubicin-induced oxidative stress and cardiac apoptosis through activating p38 and JNK MAPK mediated Nrf2/ARE pathway. Chemico-Biological Interactions 305:54–65. doi: 10.1016/j.cbi.2019.03.027.
   PubMed Web of Science ®Google Scholar
• Zhao, C., X. Z. Wan, S. Zhou, and H. Cao. 2020. Natural polyphenols: A potential therapeutic approach to hypoglycemia. eFood 1 (2):107–18. doi: 10.2991/efood.k.200302.001.
   Google Scholar
• Zhao, J., Y. Han, Z. Wang, R. Zhang, G. Wang, and Y. Mao. 2020. Alginate oligosaccharide protects endothelial cells against oxidative stress injury via integrin-alpha/FAK/PI3K signaling. Biotechnology Letters 42 (12):2749–58. doi: 10.1007/s10529-020-03010-z.
   PubMed Web of Science ®Google Scholar
• Zhao, J.-F., L.-C. Ching, Y.-C. Huang, C.-Y. Chen, A.-N. Chiang, Y. R. Kou, S.-K. Shyue, and T.-S. Lee. 2012. Molecular mechanism of curcumin on the suppression of cholesterol accumulation in macrophage foam cells and atherosclerosis. Molecular Nutrition & Food Research 56 (5):691–701. doi: 10.1002/mnfr.201100735.
   PubMed Web of Science ®Google Scholar
• Zhao, R. Z., X. L. Ma, X. P. Xie, and G. X. Shen. 2009. Involvement of NADPH oxidase in oxidized LDL-induced upregulation of heat shock factor-1 and plasminogen activator inhibitor-1 in vascular endothelial cells. American Journal of Physiology. Endocrinology and Metabolism 297 (1):E104–E111. doi: 10.1152/ajpendo.91023.2008.
   PubMed Web of Science ®Google Scholar
• Zhazykbayeva, S., S. Pabel, A. Mugge, S. Sossalla, and N. Hamdani. 2020. The molecular mechanisms associated with the physiological responses to inflammation and oxidative stress in cardiovascular diseases. Biophysical Reviews 12 (4):947–68. doi: 10.1007/s12551-020-00742-0.
   PubMedGoogle Scholar
• Zhong, R. T., M. A. Farag, M. W. Chen, C. W. He, and J. B. Xiao. 2022. Recent advances in the biosynthesis, structure–activity relationships, formulations, pharmacology, and clinical trials of fisetin. eFood 3 (1–2):e3. doi: 10.1002/efd2.3.
   Google Scholar
• Zhou, F.-H., X.-J. Deng, Y.-Q. Chen, F.-L. Ya, X.-D. Zhang, F. Song, D. Li, and Y. Yang. 2017. Anthocyanin Cyanidin-3-Glucoside attenuates platelet granule release in mice fed high-fat diets. Journal of Nutritional Science and Vitaminology 63 (4):237–43. doi: 10.3177/jnsv.63.237.
   PubMed Web of Science ®Google Scholar
• Zhou, J., Y. Chen, J.-Y. Lang, J.-J. Lu, and J. Ding. 2008. Salvicine inactivates beta(1) integrin and inhibits adhesion of MDA-MB-435 cells to fibronectin via reactive oxygen species signaling. Molecular Cancer Research: MCR 6 (2):194–204. doi: 10.1158/1541-7786.mcr-07-0197.
   PubMed Web of Science ®Google Scholar
• Zhou, S. S., W. Q. Sun, Z. G. Zhang, and Y. Zheng. 2014. The role of Nrf2-mediated pathway in cardiac remodeling and heart failure. Oxidative Medicine and Cellular Longevity 2014:260429. doi: 10.1155/2014/260429.
   PubMed Web of Science ®Google Scholar