Anti-aging effects and mechanisms of anthocyanins and their intestinal microflora metabolites

References

• Abdelmageed, M. E., G. S. Shehatou, G. M. Suddek, and H. A. Salem. 2021. Protocatechuic acid improves hepatic insulin resistance and restores vascular oxidative status in type-2 diabetic rats. Environmental Toxicology and Pharmacology 83:103577.
   PubMed Web of Science ®Google Scholar
• Al-Saeed, A. H., M. I. Constantino, L. Molyneaux, M. D’Souza, F. Limacher-Gisler, C. Luo, T. Wu, S. M. Twigg, D. K. Yue, and J. Wong. 2016. An inverse relationship between age of type 2 diabetes onset and complication risk and mortality: The impact of youth-onset type 2 diabetes. Diabetes Care 39 (5):823–9. doi: 10.2337/dc15-0991.
   PubMed Web of Science ®Google Scholar
• Aman, Y., T. Schmauck-Medina, M. Hansen, R. I. Morimoto, A. K. Simon, I. Bjedov, K. Palikaras, A. Simonsen, T. Johansen, N. Tavernarakis, et al. 2021. Autophagy in healthy aging and disease. Nature Aging 1 (8):634–50. doi: 10.1038/s43587-021-00098-4.
   PubMedGoogle Scholar
• Aravind, S. M., S. Wichienchot, R. Tsao, S. Ramakrishnan, and S. Chakkaravarthi. 2021. Role of dietary polyphenols on gut microbiota, their metabolites and health benefits. Food Research International (Ottawa, Ont.) 142:110189.
   PubMed Web of Science ®Google Scholar
• Aura, A.-M., P. Martin-Lopez, K. A. O'Leary, G. Williamson, K.-M. Oksman-Caldentey, K. Poutanen, and C. Santos-Buelga. 2005. In vitro metabolism of anthocyanins by human gut microflora. European Journal of Nutrition 44 (3):133–42. doi: 10.1007/s00394-004-0502-2.
   PubMed Web of Science ®Google Scholar
• Barbosa, P., P. Araújo, J. Oliveira, I. Fraga, J. Pissarra, and C. Amaral. 2019. Metabolic pathways of degradation of malvidin-3-O-monoglucoside by Candida oleophila. International Biodeterioration & Biodegradation 144:104768. doi: 10.1016/j.ibiod.2019.104768.
   Web of Science ®Google Scholar
• Barha, C. K., C.-L T. Hsu, L. Brinke, and T. Liu-Ambrose. 2019. Biological sex: A potential moderator of physical activity efficacy on brain health. Frontiers in Aging Neuroscience 11 (329) doi: 10.3389/fnagi.2019.00329.
   PubMedGoogle Scholar
• Blackburn, E. H., E. S. Epel, and J. Lin. 2015. Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection. Science (New York, N.Y.) 350 (6265):1193–8. doi: 10.1126/science.aab3389.
   PubMed Web of Science ®Google Scholar
• Borges, G., S. Roowi, J. M. Rouanet, G. G. Duthie, M. E. Lean, and A. Crozier. 2007. The bioavailability of raspberry anthocyanins and ellagitannins in rats. Molecular Nutrition & Food Research 51 (6):714–25. doi: 10.1002/mnfr.200700024.
   PubMed Web of Science ®Google Scholar
• Bouzaiene, N. N., S. K. Jaziri, H. Kovacic, L. Chekir-Ghedira, K. Ghedira, and J. Luis. 2015. The effects of caffeic, coumaric and ferulic acids on proliferation, superoxide production, adhesion and migration of human tumor cells in vitro. European Journal of Pharmacology 766:99–105.
   PubMed Web of Science ®Google Scholar
• Bovilla, V. R., P. G. Anantharaju, S. Dornadula, P. M. Veeresh, M. G. Kuruburu, V. G. Bettada, K. M. Ramkumar, and S. V. Madhunapantula. 2021. Caffeic acid and protocatechuic acid modulate Nrf2 and inhibit Ehrlich ascites carcinomas in mice. Asian Pacific Journal of Tropical Biomedicine 11 (6):244. doi: 10.4103/2221-1691.314045.
   Web of Science ®Google Scholar
• Cai, Z., J. Zhang, and H. Li. 2019. Selenium, aging and aging-related diseases. Aging Clinical and Experimental Research 31 (8):1035–47. doi: 10.1007/s40520-018-1086-7.
   PubMed Web of Science ®Google Scholar
• Campisi, J. 2013. Aging, cellular senescence, and cancer. Annual Review of Physiology 75:685–705.
   PubMed Web of Science ®Google Scholar
• Cao, X., Y. Xia, M. Zeng, W. Wang, Y. He, and J. Liu. 2019. Caffeic acid inhibits the formation of advanced glycation end products (AGEs) and mitigates the AGEs‐induced oxidative stress and inflammation reaction in human umbilical vein endothelial cells (HUVECs. )Chemistry & Biodiversity 16 (10):e1900174. doi: 10.1002/cbdv.201900174.
   PubMed Web of Science ®Google Scholar
• Chen, J., J. Zhang, Y. Xiang, L. Xiang, Y. Liu, X. He, X. Zhou, X. Liu, and Z. Huang. 2016. Extracts of Tsai Tai (Brassica chinensis): enhanced antioxidant activity and anti-aging effects both in vitro and in Caenorhabditis elegans. Food & Function 7 (2):943–52. doi: 10.1039/c5fo01241d.
   PubMed Web of Science ®Google Scholar
• Chen, W., D. Müller, E. Richling, and M. Wink. 2013. Anthocyanin-rich purple wheat prolongs the life span of Caenorhabditis elegans ­probably by activating the DAF-16/FOXO transcription factor. Journal of Agricultural and Food Chemistry 61 (12):3047–53. doi: 10.1021/jf3054643.
   PubMed Web of Science ®Google Scholar
• Chen, Y., Q. Li, T. Zhao, Z. Zhang, G. Mao, W. Feng, X. Wu, and L. Yang. 2017. Biotransformation and metabolism of three mulberry anthocyanin monomers by rat gut microflora. Food Chemistry 237:887–94.
   PubMed Web of Science ®Google Scholar
• Chiang, W.-C., T.-T. Ching, H. C. Lee, C. Mousigian, and A.-L. Hsu. 2012. HSF-1 regulators DDL-1/2 link insulin-like signaling to heat-shock responses and modulation of longevity. Cell 148 (1-2):322–34. doi: 10.1016/j.cell.2011.12.019.
   PubMed Web of Science ®Google Scholar
• Choi, M. J., B. K. Kim, K. Y. Park, T. Yokozawa, Y. O. Song, and E. J. Cho. 2010. Anti-aging effects of cyanidin under a stress-induced premature senescence cellular system. Biological & Pharmaceutical Bulletin 33 (3):421–6. doi: 10.1248/bpb.33.421.
   PubMed Web of Science ®Google Scholar
• Cortés-Martín, A., M. V. Selma, F. A. Tomás‐Barberán, A. González‐Sarrías, and J. C. Espín. 2020. Where to look into the puzzle of polyphenols and health? The postbiotics and gut microbiota associated with human metabotypes. Molecular Nutrition & Food Research 64 (9):1900952. doi: 10.1002/mnfr.201900952.
   PubMed Web of Science ®Google Scholar
• Czank, C., A. Cassidy, Q. Zhang, D. J. Morrison, T. Preston, P. A. Kroon, N. P. Botting, and C. D. Kay. 2013. Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: A 13C-tracer study. The American Journal of Clinical Nutrition 97 (5):995–1003. doi: 10.3945/ajcn.112.049247.
   PubMed Web of Science ®Google Scholar
• de Aguiar Cipriano, P., H. Kim, C. Fang, V. P. Venancio, S. U. Mertens-Talcott, and S. T. Talcott. 2022. In vitro digestion, absorption and biological activities of acylated anthocyanins from purple sweet potatoes (Ipomoea batatas). Food Chemistry 374:131076.
   PubMed Web of Science ®Google Scholar
• De Ferrars, R. M., C. Czank, Q. Zhang, N. P. Botting, P. A. Kroon, A. Cassidy, and C. D. Kay. 2014. The pharmacokinetics of anthocyanins and their metabolites in humans. British Journal of Pharmacology 171 (13):3268–82. doi: 10.1111/bph.12676.
   PubMed Web of Science ®Google Scholar
• Diaconeasa, Z., I. Știrbu, J. Xiao, N. Leopold, Z. Ayvaz, C. Danciu, H. Ayvaz, A. Stǎnilǎ, M. Nistor, and C. Socaciu. 2020. Anthocyanins, vibrant color pigments, and their role in skin cancer prevention. Biomedicines 8 (9):336. doi: 10.3390/biomedicines8090336.
   PubMed Web of Science ®Google Scholar
• Dilberger, B., S. Weppler, and G. P. Eckert. 2021. Phenolic acid metabolites of polyphenols act as inductors for hormesis in C. elegans. Mechanisms of Ageing and Development 198:111518. doi: 10.1016/j.mad.2021.111518.
   PubMed Web of Science ®Google Scholar
• Fan, Z., H. Wen, X. Zhang, J. Li, and J. Zang. 2022. Cyanidin 3-O-β-Galactoside alleviated cognitive impairment in mice by regulating brain energy metabolism during aging. Journal of Agricultural and Food Chemistry 70 (4):1111–21. doi: 10.1021/acs.jafc.1c06240.
   PubMed Web of Science ®Google Scholar
• Fang, J. 2014. Bioavailability of anthocyanins. Drug Metabolism Reviews 46 (4):508–20. doi: 10.3109/03602532.2014.978080.
   PubMed Web of Science ®Google Scholar
• Faria, A., D. Pestana, J. Azevedo, F. Martel, V. de Freitas, I. Azevedo, N. Mateus, and C. Calhau. 2009. Absorption of anthocyanins through intestinal epithelial cells–Putative involvement of GLUT2. Molecular Nutrition & Food Research 53 (11):1430–7. doi: 10.1002/mnfr.200900007.
   PubMed Web of Science ®Google Scholar
• Felgines, C., S. Krisa, A. Mauray, C. Besson, J.-L. Lamaison, A. Scalbert, J.-M. Mérillon, and O. Texier. 2010. Radiolabelled cyanidin 3-O-glucoside is poorly absorbed in the mouse. The British Journal of Nutrition 103 (12):1738–45. doi: 10.1017/S0007114510000061.
   PubMed Web of Science ®Google Scholar
• Fernandes, I., V. de Freitas, C. Reis, and N. Mateus. 2012. A new approach on the gastric absorption of anthocyanins. Food & Function 3 (5):508–16. doi: 10.1039/c2fo10295a.
   PubMed Web of Science ®Google Scholar
• Fernandes, I., A. Faria, V. de Freitas, C. Calhau, and N. Mateus. 2015. Multiple-approach studies to assess anthocyanin bioavailability. Phytochemistry Reviews 14 (6):899–919. doi: 10.1007/s11101-015-9415-3.
   Web of Science ®Google Scholar
• Fleschhut, J., F. Kratzer, G. Rechkemmer, and S. E. Kulling. 2006. Stability and biotransformation of various dietary anthocyanins in vitro. European Journal of Nutrition 45 (1):7–18. doi: 10.1007/s00394-005-0557-8.
   PubMed Web of Science ®Google Scholar
• Flores, G., M. L. R. del Castillo, A. Costabile, A. Klee, K. B. Guergoletto, and G. R. Gibson. 2015. In vitro fermentation of anthocyanins encapsulated with cyclodextrins: Release, metabolism and influence on gut microbiota growth. Journal of Functional Foods 16:50–7. doi: 10.1016/j.jff.2015.04.022.
   Web of Science ®Google Scholar
• Forester, S. C, and A. L. Waterhouse. 2008. Identification of Cabernet Sauvignon anthocyanin gut microflora metabolites. Journal of Agricultural and Food Chemistry 56 (19):9299–304. doi: 10.1021/jf801309n.
   PubMed Web of Science ®Google Scholar
• Fornasaro, S., L. Ziberna, M. Gasperotti, F. Tramer, U. Vrhovšek, F. Mattivi, and S. Passamonti. 2016. Determination of cyanidin 3-glucoside in rat brain, liver and kidneys by UPLC/MS-MS and its application to a short-term pharmacokinetic study. Scientific Reports 6 (1):22815–1. doi: 10.1038/srep22815.
   PubMedGoogle Scholar
• Gallardo-Fernández, M., R. Hornedo-Ortega, A. B. Cerezo, A. M. Troncoso, and M. C. García-Parrilla. 2019. Melatonin, protocatechuic acid and hydroxytyrosol effects on vitagenes system against alpha-synuclein toxicity. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 134:110817.
   PubMed Web of Science ®Google Scholar
• Gao, Y., R. Tian, H. Liu, H. Xue, R. Zhang, S. Han, L. Ji, W. Huang, J. Zhan, and Y. You. 2021. Research progress on intervention effect and mechanism of protocatechuic acid on nonalcoholic fatty liver disease. Critical Reviews in Food Science and Nutrition 61:1–23. doi: 10.1080/10408398.2021.1939265.
   PubMedGoogle Scholar
• Golubev, D., N. Zemskaya, O. Shevchenko, M. Shaposhnikov, D. Kukuman, S. Patov, V. Punegov, and A. Moskalev. 2022. Honeysuckle extract (Lonicera pallasii L.) exerts antioxidant properties and extends the lifespan and healthspan of Drosophila melanogaster. Biogerontology 23 (2):215–35. doi: 10.1007/s10522-022-09954-1.
   PubMed Web of Science ®Google Scholar
• Gutierrez-Zetina, S. M., S. González-Manzano, B. Ayuda-Durán, C. Santos-Buelga, and A. M. González-Paramás. 2021. Caffeic and dihydrocaffeic acids promote longevity and increase stress resistance in Caenorhabditis elegans by modulating expression of stress-related genes. Molecules 26 (6):1517. doi: 10.3390/molecules26061517.
   PubMed Web of Science ®Google Scholar
• Han, F., P. Yang, H. Wang, I. Fernandes, N. Mateus, and Y. Liu. 2019. Digestion and absorption of red grape and wine anthocyanins through the gastrointestinal tract. Trends in Food Science & Technology 83:211–24. doi: 10.1016/j.tifs.2018.11.025.
   Web of Science ®Google Scholar
• Han, Y., Y. Guo, S. W. Cui, H. Li, Y. Shan, and H. Wang. 2021. Purple sweet potato extract extends lifespan by activating autophagy pathway in male drosophila melanogaster. Experimental Gerontology 144:111190.
   PubMed Web of Science ®Google Scholar
• Herrera-Bravo, J., J. F. Beltrán, N. Huard, K. Saavedra, N. Saavedra, M. Alvear, F. Lanas, and L. A. Salazar. 2022. Anthocyanins Found in Pinot Noir Waste Induce Target Genes Related to the Nrf2 Signalling in Endothelial Cells. Antioxidants 11 (7):1239. doi: 10.3390/antiox11071239.
   Web of Science ®Google Scholar
• Herrera-Balandrano, D. D., Z. Chai, T. Beta, J. Feng, and W. Huang. 2021. Blueberry anthocyanins: An updated review on approaches to enhancing their bioavailability. Trends in Food Science & Technology 118:808–21. doi: 10.1016/j.tifs.2021.11.006.
   Web of Science ®Google Scholar
• Herrera-Sotero, M. Y., C. D. Cruz-Hernández, R. M. Oliart-Ros, J. L. Chávez-Servia, R. I. Guzmán-Gerónimo, V. González-Covarrubias, M. Cruz-Burgos, and M. Rodríguez-Dorantes. 2020. Anthocyanins of blue corn and tortilla arrest cell cycle and induce apoptosis on breast and prostate cancer cells. Nutrition and Cancer 72 (5):768–77. doi: 10.1080/01635581.2019.1654529.
   PubMed Web of Science ®Google Scholar
• Huang, B., Z. Wang, J. H. Park, O. H. Ryu, M. K. Choi, J.-Y. Lee, Y.-H. Kang, and S. S. Lim. 2015. Anti-diabetic effect of purple corn extract on C57BL/KsJ db/db mice. Nutrition Research and Practice 9 (1):22–9. doi: 10.4162/nrp.2015.9.1.22.
   PubMed Web of Science ®Google Scholar
• Izzo, C., A. Carrizzo, A. Alfano, N. Virtuoso, M. Capunzo, M. Calabrese, E. De Simone, S. Sciarretta, G. Frati, M. Oliveti, et al. 2018. The impact of aging on cardio and cerebrovascular diseases. International Journal of Molecular Sciences 19 (2):481. doi: 10.3390/ijms19020481.
   PubMed Web of Science ®Google Scholar
• Jabeen, A., N. Parween, K. Sayrav, and B. Prasad. 2020. Date (Phoenix dactylifera) seed and syringic acid exhibits antioxidative effect and lifespan extending properties in Caenorhabditis elegans. Arabian Journal of Chemistry 13 (12):9058–67. doi: 10.1016/j.arabjc.2020.10.028.
   Web of Science ®Google Scholar
• Jang, S.-E., J.-R. Choi, M. J. Han, and D.-H. Kim. 2016. The preventive and curative effect of cyanidin-3β-D-glycoside and its ­metabolite protocatechuic acid against TNBS-induced colitis in mice. Natural Product Sciences 22 (4):282–6. doi: 10.20307/nps.2016.22.4.282.
   Google Scholar
• Jaskiw, G. E., M. E. Obrenovich, and C. J. Donskey. 2019. The phenolic interactome and gut microbiota: Opportunities and challenges in developing applications for schizophrenia and autism. Psychopharmacology 236 (5):1471–89. doi: 10.1007/s00213-019-05267-3.
   PubMed Web of Science ®Google Scholar
• Jayarathne, S., L. Ramalingam, H. Edwards, S. A. Vanapalli, and N. Moustaid-Moussa. 2020. Tart cherry increases lifespan in Caenorhabditis elegans by altering metabolic signaling pathways. Nutrients 12 (5):1482. doi: 10.3390/nu12051482.
   PubMed Web of Science ®Google Scholar
• Jaye, K., C. G. Li, and D. J. Bhuyan. 2021. The complex interplay of gut microbiota with the five most common cancer types: From carcinogenesis to therapeutics to prognoses. Critical Reviews in Oncology/Hematology 165:103429. doi: 10.1016/j.critrevonc.2021.103429.
   PubMed Web of Science ®Google Scholar
• Joo, H. K., S. Choi, Y. R. Lee, E. O. Lee, M. S. Park, K. B. Park, C.-S. Kim, Y. P. Lim, J.-T. Park, and B. H. Jeon. 2018. Anthocyanin-rich extract from red Chinese cabbage alleviates vascular inflammation in endothelial cells and Apo E−/− mice. International Journal of Molecular Sciences 19 (3):816. doi: 10.3390/ijms19030816.
   PubMed Web of Science ®Google Scholar
• Jung, S., M.-S. Lee, E. Chang, C.-T. Kim, and Y. Kim. 2021. Mulberry (Morus alba L.) fruit extract ameliorates inflammation via regulating microRNA-21/132/143 expression and increases the skeletal muscle mitochondrial content and AMPK/SIRT activities. Antioxidants 10 (9):1453. doi: 10.3390/antiox10091453.
   Web of Science ®Google Scholar
• Kamonpatana, K., M. L. Failla, P. S. Kumar, and M. M. Giusti. 2014. Anthocyanin structure determines susceptibility to microbial degradation and bioavailability to the buccal mucosa. Journal of Agricultural and Food Chemistry 62 (29):6903–10. doi: 10.1021/jf405180k.
   PubMed Web of Science ®Google Scholar
• Kamonpatana, K., M. M. Giusti, C. Chitchumroonchokchai, M. MorenoCruz, K. M. Riedl, P. Kumar, and M. L. Failla. 2012. Susceptibility of anthocyanins to ex vivo degradation in human saliva. Food Chemistry 135 (2):738–47. doi: 10.1016/j.foodchem.2012.04.110.
   PubMed Web of Science ®Google Scholar
• Kim, D. K., H. Jeon, and D. S. Cha. 2014. 4-Hydroxybenzoic acid-mediated lifespan extension in Caenorhabditis elegans. Journal of Functional Foods 7:630–40. doi: 10.1016/j.jff.2013.12.022.
   Web of Science ®Google Scholar
• Kim, Y. S., H. W. Seo, M.-H. Lee, D. K. Kim, H. Jeon, and D. S. Cha. 2014. Protocatechuic acid extends lifespan and increases stress resistance in Caenorhabditis elegans. Archives of Pharmacal Research 37 (2):245–52.
   PubMed Web of Science ®Google Scholar
• Klaips, C. L., G. G. Jayaraj, and F. U. Hartl. 2018. Pathways of cellular proteostasis in aging and disease. The Journal of Cell Biology 217 (1):51–63. doi: 10.1083/jcb.201709072.
   PubMed Web of Science ®Google Scholar
• Kristiani, L., M. Kim, and Y. Kim. 2020. Role of the nuclear lamina in age-associated nuclear reorganization and inflammation. Cells 9 (3):718. doi: 10.3390/cells9030718.
   PubMed Web of Science ®Google Scholar
• Lee, A.-T., M.-Y. Yang, Y.-J. Lee, T.-W. Yang, C.-C. Wang, and C.-J. Wang. 2021. Gallic acid improves diabetic steatosis by downregulating microRNA-34a-5p through targeting NFE2L2 expression in high-fat diet-fed db/db mice. Antioxidants 11 (1):92. doi: 10.3390/antiox11010092.
   Web of Science ®Google Scholar
• Lee, S. G., C. R. Brownmiller, S.-O. Lee, and H. W. Kang. 2020. Anti-inflammatory and antioxidant effects of anthocyanins of Trifolium pratense (red clover) in lipopolysaccharide-stimulated RAW-267.4 macrophages. Nutrients 12 (4):1089. doi: 10.3390/nu12041089.
   PubMed Web of Science ®Google Scholar
• Li, H., X. Yu, C. Li, L. Ma, Z. Zhao, S. Guan, and L. Wang. 2021. Caffeic acid protects against Aβ toxicity and prolongs lifespan in Caenorhabditis elegans models. Food & Function 12 (3):1219–31.
   PubMed Web of Science ®Google Scholar
• Li, H., T. Zheng, F. Lian, T. Xu, W. Yin, and Y. Jiang. 2022. Anthocyanin-rich blueberry extracts and anthocyanin metabolite protocatechuic acid promote autophagy-lysosomal pathway and alleviate neurons damage in in vivo and in vitro models of Alzheimer’s disease. Nutrition (Burbank, Los Angeles County, Calif.) 93:111473. doi: 10.1016/j.nut.2021.111473.
   PubMed Web of Science ®Google Scholar
• Li, P., D. Feng, D. Yang, X. Li, J. Sun, G. Wang, L. Tian, X. Jiang, and W. Bai. 2021. Protective effects of anthocyanins on neurodegenerative diseases. Trends in Food Science & Technology 117:205–17. doi: 10.1016/j.tifs.2021.05.005.
   Web of Science ®Google Scholar
• Li, R., M. Tao, T. Xu, S. Pan, X. Xu, and T. Wu. 2021. Small berries as health-promoting ingredients: A review on anti-aging effects and mechanisms in Caenorhabditis elegans. Food & Function 13 (2):478–500. doi: 10.1039/D1FO02184B.
   Web of Science ®Google Scholar
• Li, S., B. Wu, W. Fu, and L. Reddivari. 2019. The anti-inflammatory effects of dietary anthocyanins against ulcerative colitis. International Journal of Molecular Sciences 20 (10):2588. doi: 10.3390/ijms20102588.
   PubMed Web of Science ®Google Scholar
• Li, X., Z. Shi, Y. Zhu, T. Shen, H. Wang, G. Shui, J. J. Loor, Z. Fang, M. Chen, X. Wang, et al. 2020. Cyanidin‐3‐O‐glucoside improves non‐alcoholic fatty liver disease by promoting PINK1‐mediated mitophagy in mice. British Journal of Pharmacology 177 (15):3591–607. doi: 10.1111/bph.15083.
   PubMed Web of Science ®Google Scholar
• Li, Z., Z. Zhang, Y. Ren, Y. Wang, J. Fang, H. Yue, S. Ma, and F. Guan. 2021. Aging and age‐related diseases: From mechanisms to therapeutic strategies. Biogerontology 22 (2):165–87.
   PubMed Web of Science ®Google Scholar
• Liang, N, and D. D. Kitts. 2014. Antioxidant property of coffee components: Assessment of methods that define mechanisms of action. Molecules (Basel, Switzerland) 19 (11):19180–208. doi: 10.3390/molecules191119180.
   PubMed Web of Science ®Google Scholar
• Lila, M. A., B. Burton-Freeman, M. Grace, and W. Kalt. 2016. Unraveling anthocyanin bioavailability for human health. Annual Review of Food Science and Technology 7:375–93.
   PubMed Web of Science ®Google Scholar
• Liu, Y., D. Zhang, Y. Wu, D. Wang, Y. Wei, J. Wu, and B. Ji. 2014. Stability and absorption of anthocyanins from blueberries subjected to a simulated digestion process. International Journal of Food Sciences and Nutrition 65 (4):440–8. doi: 10.3109/09637486.2013.869798.
   PubMed Web of Science ®Google Scholar
• Liu, Y., Z. Zhou, L. Yin, M. Zhu, F. Wang, L. Zhang, H. Wang, Z. Zhou, H. Zhu, C. Huang, et al. 2022. Tangeretin promotes lifespan associated with insulin/insulin‐like growth factor‐1 signaling pathway and heat resistance in Caenorhabditis elegans. BioFactors (Oxford, England) 48 (2):442–53. doi: 10.1002/biof.1788.
   PubMed Web of Science ®Google Scholar
• Long, J., H. Gao, L. Sun, J. Liu, and X. Zhao-Wilson. 2009. Grape extract protects mitochondria from oxidative damage and improves locomotor dysfunction and extends lifespan in a Drosophila Parkinson’s disease model. Rejuvenation Research 12 (5):321–31. doi: 10.1089/rej.2009.0877.
   PubMed Web of Science ®Google Scholar
• Luo, J., H. Si, Z. Jia, and D. Liu. 2021. Dietary anti-aging polyphenols and potential mechanisms. Antioxidants 10 (2):283. doi: 10.3390/antiox10020283.
   Web of Science ®Google Scholar
• Ma, H., S. L. Johnson, W. Liu, N. A. DaSilva, S. Meschwitz, J. A. Dain, and N. P. Seeram. 2018. Evaluation of polyphenol anthocyanin-enriched extracts of blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry for free radical scavenging, reactive carbonyl species trapping, anti-glycation, anti-β-amyloid aggregation, and microglial neuroprotective effects. International Journal of Molecular Sciences 19 (2):461. doi: 10.3390/ijms19020461.
   PubMed Web of Science ®Google Scholar
• Mahjoob, M, and U. Stochaj. 2021. Curcumin nanoformulations to combat aging-related diseases. Ageing Research Reviews 69:101364.
   PubMed Web of Science ®Google Scholar
• Maleki, M., N. Khelghati, F. Alemi, M. Bazdar, Z. Asemi, M. Majidinia, A. Sadeghpoor, A. Mahmoodpoor, F. Jadidi-Niaragh, N. Targhazeh, et al. 2020. Stabilization of telomere by the antioxidant property of polyphenols: Anti-aging potential. Life Sciences 259:118341. doi: 10.1016/j.lfs.2020.118341.
   PubMed Web of Science ®Google Scholar
• Mallery, S. R., D. E. Budendorf, M. P. Larsen, P. Pei, M. Tong, A. S. Holpuch, P. E. Larsen, G. D. Stoner, H. W. Fields, K. K. Chan, et al. 2011. Effects of human oral mucosal tissue, saliva, and oral microflora on intraoral metabolism and bioactivation of black raspberry anthocyanins. Cancer Prevention Research (Philadelphia, Pa.) 4 (8):1209–21. doi: 10.1158/1940-6207.CAPR-11-0040.
   PubMed Web of Science ®Google Scholar
• Manolescu, B. N., E. Oprea, M. Mititelu, L. L. Ruta, and I. C. Farcasanu. 2019. Dietary anthocyanins and stroke: A review of pharmacokinetic and pharmacodynamic studies. Nutrients 11 (7):1479. doi: 10.3390/nu11071479.
   PubMed Web of Science ®Google Scholar
• Martell, J., Y. Seo, D. W. Bak, S. F. Kingsley, H. A. Tissenbaum, and E. Weerapana. 2016. Global cysteine-reactivity profiling during impaired Insulin/IGF-1 signaling in C. elegans identifies uncharacterized mediators of longevity. Cell Chemical Biology 23 (8):955–66. doi: 10.1016/j.chembiol.2016.06.015.
   PubMed Web of Science ®Google Scholar
• Mas-Bargues, C., M. Alique, M. T. Barrús-Ortiz, C. Borrás, and R. Rodrigues-Díez. 2021. Exploring new kingdoms: The role of extracellular vesicles in oxi-inflamm-aging related to cardiorenal syndrome. Antioxidants 11 (1):78. doi: 10.3390/antiox11010078.
   Web of Science ®Google Scholar
• Maya, S., T. Prakash, and D. Goli. 2018. Evaluation of neuroprotective effects of wedelolactone and gallic acid on aluminium-induced neurodegeneration: Relevance to sporadic amyotrophic lateral sclerosis. European Journal of Pharmacology 835:41–51. doi: 10.1016/j.ejphar.2018.07.058.
   PubMed Web of Science ®Google Scholar
• Mehmood, A., M. Usman, P. Patil, L. Zhao, and C. Wang. 2020. A review on management of cardiovascular diseases by olive polyphenols. Food Science & Nutrition 8 (9):4639–55. doi: 10.1002/fsn3.1668.
   PubMed Web of Science ®Google Scholar
• Mehmood, A., L. Zhao, Y. Wang, F. Pan, S. Hao, H. Zhang, A. Iftikhar, and M. Usman. 2021. Dietary anthocyanins as potential natural modulators for the prevention and treatment of non-alcoholic fatty liver disease: A comprehensive review. Food Research International (Ottawa, Ont.) 142:110180. doi: 10.1016/j.foodres.2021.110180.
   PubMed Web of Science ®Google Scholar
• Min, J., H. Shen, W. Xi, Q. Wang, L. Yin, Y. Zhang, Y. Yu, Q. Yang, and Z-n Wang. 2018. Synergistic anticancer activity of combined use of caffeic acid with paclitaxel enhances apoptosis of non-small-cell lung cancer H1299 cells in vivo and in vitro. Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology 48 (4):1433–42. doi: 10.1159/000492253.
   PubMedGoogle Scholar
• Min, S.-W., S.-N. Ryu, and D.-H. Kim. 2010. Anti-inflammatory effects of black rice, cyanidin-3-O-β-D-glycoside, and its metabolites, cyanidin and protocatechuic acid. International Immunopharmacology 10 (8):959–66. doi: 10.1016/j.intimp.2010.05.009.
   PubMed Web of Science ®Google Scholar
• Miyazaki, K., K. Makino, E. Iwadate, Y. Deguchi, and F. Ishikawa. 2008. Anthocyanins from purple sweet potato Ipomoea batatas cultivar Ayamurasaki suppress the development of atherosclerotic lesions and both enhancements of oxidative stress and soluble vascular cell adhesion molecule-1 in apolipoprotein E-deficient mice. Journal of Agricultural and Food Chemistry 56 (23):11485–92. doi: 10.1021/jf801876n.
   PubMed Web of Science ®Google Scholar
• Molagoda, I. M. N., K. T. Lee, Y. H. Choi, and G.-Y. Kim. 2020. Anthocyanins from Hibiscus syriacus L. inhibit oxidative stress-mediated apoptosis by activating the Nrf2/HO-1 signaling pathway. Antioxidants 9 (1):42. doi: 10.3390/antiox9010042.
   Web of Science ®Google Scholar
• Moskalev, A., Z. Guvatova, I. D. A. Lopes, C. W. Beckett, B. K. Kennedy, J. P. De Magalhaes, and A. A. Makarov. 2022. Targeting aging mechanisms: Pharmacological perspectives. Trends in Endocrinology & Metabolism 33 (4):266–80. doi: 10.1016/j.tem.2022.01.007.
   PubMed Web of Science ®Google Scholar
• Mueller, D., K. Jung, M. Winter, D. Rogoll, R. Melcher, and E. Richling. 2017. Human intervention study to investigate the intestinal accessibility and bioavailability of anthocyanins from bilberries. Food Chemistry 231:275–86.
   PubMed Web of Science ®Google Scholar
• Nakano, H., S. Wu, K. Sakao, T. Hara, J. He, S. Garcia, K. Shetty, and D.-X. Hou. 2020. Bilberry anthocyanins ameliorate NAFLD by improving dyslipidemia and gut microbiome dysbiosis. Nutrients 12 (11):3252. doi: 10.3390/nu12113252.
   PubMed Web of Science ®Google Scholar
• Nasa, J. S. B., Manaloa, R. V. M. Medinaa, and P. M. B. 2021. Peonidin-3-glucoside extends the lifespan of Caenorhabditis elegans and enhances its tolerance to heat, UV, and oxidative stresses. Scienceasia 47 (4):457. +.
   Web of Science ®Google Scholar
• Nguyen, N. N., Rana, A. Goldman, C. Moore, R. Tai, J. Hong, Y. Shen, J. Walker, D. W. Hur, and J. H. 2019. Proteasome β5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila melanogaster. Scientific Reports 9 (1):1–12. doi: 10.1038/s41598-019-39508-4.
   PubMedGoogle Scholar
• Nurmi, T., J. Mursu, M. Heinonen, A. Nurmi, R. Hiltunen, and S. Voutilainen. 2009. Metabolism of berry anthocyanins to phenolic acids in humans. Journal of Agricultural and Food Chemistry 57 (6):2274–81. doi: 10.1021/jf8035116.
   PubMed Web of Science ®Google Scholar
• Oliveira, H., I. Fernandes, N. F. Bras, A. Faria, V. De Freitas, C. a o Calhau, and N. Mateus. 2015. Experimental and theoretical data on the mechanism by which red wine anthocyanins are transported through a human MKN-28 gastric cell model. Journal of Agricultural and Food Chemistry 63 (35):7685–92. doi: 10.1021/acs.jafc.5b00412.
   PubMed Web of Science ®Google Scholar
• Oliveira, H., C. Roma-Rodrigues, A. Santos, B. Veigas, N. Brás, A. Faria, C. Calhau, V. de Freitas, P. V. Baptista, N. Mateus, et al. 2019. GLUT1 and GLUT3 involvement in anthocyanin gastric transport-Nanobased targeted approach. Scientific Reports 9 (1):1–14. doi: 10.1038/s41598-018-37283-2.
   PubMedGoogle Scholar
• Paramanantham, A., M. J. Kim, E. J. Jung, H. J. Kim, S.-H. Chang, J.-M. Jung, S. C. Hong, S. C. Shin, G. S. Kim, and W. S. Lee. 2020. Anthocyanins isolated from vitis coignetiae pulliat enhances cisplatin sensitivity in MCF-7 human breast cancer cells through inhibition of Akt and NF-κB activation. Molecules 25 (16):3623. doi: 10.3390/molecules25163623.
   PubMed Web of Science ®Google Scholar
• Peixoto, H., M. Roxo, S. Krstin, T. Röhrig, E. Richling, and M. Wink. 2016. An anthocyanin-rich extract of acai (Euterpe precatoria Mart.) increases stress resistance and retards aging-related markers in Caenorhabditis elegans. Journal of Agricultural and Food Chemistry 64 (6):1283–90. doi: 10.1021/acs.jafc.5b05812.
   PubMed Web of Science ®Google Scholar
• Pointner, A., C. Mölzer, U. Magnet, K. Zappe, B. Hippe, A. Tosevska, E. Tomeva, E. Dum, D. Gessner, S. Lilja, et al. 2021. The green tea polyphenol EGCG is differentially associated with telomeric regulation in normal human fibroblasts versus cancer cells. Functional Foods in Health and Disease 11 (3):73–91. doi: 10.31989/ffhd.v11i3.775.
   Web of Science ®Google Scholar
• Rathor, L., A. Pant, H. Awasthi, D. Mani, and R. Pandey. 2017. An antidiabetic polyherbal phytomedicine confers stress resistance and extends lifespan in Caenorhabditis elegans. Biogerontology 18 (1):131–47. doi: 10.1007/s10522-016-9668-2.
   PubMed Web of Science ®Google Scholar
• Rebollo-Hernanz, M., Aguilera, Y. Martin-Cabrejas, M. A, and Gonzalez de Mejia, E. 2022. Phytochemicals from the cocoa shell modulate mitochondrial function, lipid and glucose metabolism in hepatocytes via activation of FGF21/ERK, AKT, and mTOR pathways. Antioxidants 11 (1):136. doi: 10.3390/antiox11010136.
   Web of Science ®Google Scholar
• Rodriguez-Mateos, A., R. P. Feliciano, A. Boeres, T. Weber, C. N. Dos Santos, M. R. Ventura, and C. Heiss. 2016. Cranberry (poly) phenol metabolites correlate with improvements in vascular function: A double‐blind, randomized, controlled, dose‐response, crossover study. Molecular Nutrition & Food Research 60 (10):2130–40. doi: 10.1002/mnfr.201600250.
   PubMed Web of Science ®Google Scholar
• Sandhu, A. K., M. G. Miller, N. Thangthaeng, T. M. Scott, B. Shukitt-Hale, I. Edirisinghe, and B. Burton-Freeman. 2018. Metabolic fate of strawberry polyphenols after chronic intake in healthy older adults. Food & Function 9 (1):96–106. doi: 10.1039/c7fo01843f.
   PubMed Web of Science ®Google Scholar
• Scerbak, C., E. Vayndorf, A. Hernandez, C. McGill, and B. Taylor. 2018. Lowbush cranberry acts through DAF-16/FOXO signaling to promote increased lifespan and axon branching in aging posterior touch receptor neurons. GeroScience 40 (2):151–62. doi: 10.1007/s11357-018-0016-0.
   PubMed Web of Science ®Google Scholar
• Scerbak, C., E. M. Vayndorf, A. Hernandez, C. McGill, and B. E. Taylor. 2016. Mechanosensory neuron aging: Differential trajectories with lifespan-extending Alaskan berry and fungal treatments in Caenorhabditis elegans. Frontiers in Aging Neuroscience 8 (173):173.
   PubMedGoogle Scholar
• Scheiblich, H., M. Trombly, A. Ramirez, and M. T. Heneka. 2020. Neuroimmune connections in aging and neurodegenerative diseases. Trends in Immunology 41 (4):300–12. doi: 10.1016/j.it.2020.02.002.
   PubMed Web of Science ®Google Scholar
• Sender, R., S. Fuchs, and R. Milo. 2016. Revised estimates for the number of human and bacteria cells in the body. PLoS Biology 14 (8):e1002533.
   PubMed Web of Science ®Google Scholar
• Shin, S., S. H. Cho, D. Park, and E. Jung. 2020. Anti‐skin aging properties of protocatechuic acid in vitro and in vivo. Journal of Cosmetic Dermatology 19 (4):977–84. doi: 10.1111/jocd.13086.
   PubMed Web of Science ®Google Scholar
• Song, Q., J. Liu, L. Dong, X. Wang, and X. Zhang. 2021. Novel advances in inhibiting advanced glycation end product formation using natural compounds. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 140:111750. doi: 10.1016/j.biopha.2021.111750.
   PubMed Web of Science ®Google Scholar
• Su, H., L. Xie, Y. Xu, H. Ke, T. Bao, Y. Li, and W. Chen. 2020. Pelargonidin-3-O-glucoside derived from wild raspberry exerts antihyperglycemic effect by inducing autophagy and modulating gut microbiota. Journal of Agricultural and Food Chemistry 68 (46):13025–37. doi: 10.1021/acs.jafc.9b03338.
   PubMed Web of Science ®Google Scholar
• Sun, K., Y. Sun, H. Li, D. Han, Y. Bai, R. Zhao, and Z. Guo. 2020. Anti-ageing effect of Physalis alkekengi ethyl acetate layer on a d-galactose-induced mouse model through the reduction of cellular senescence and oxidative stress. International Journal of Molecular Sciences 21 (5):1836. doi: 10.3390/ijms21051836.
   PubMed Web of Science ®Google Scholar
• Talavéra, S., C. Felgines, O. Texier, C. Besson, J.-L. Lamaison, and C. Rémésy. 2003. Anthocyanins are efficiently absorbed from the stomach in anesthetized rats. The Journal of Nutrition 133 (12):4178–82. doi: 10.1093/jn/133.12.4178.
   PubMed Web of Science ®Google Scholar
• Tambara, A. L., L. d L. S. Moraes, A. H. Dal Forno, J. R. Boldori, A. T. G. Soares, C. de Freitas Rodrigues, L. R. B. Mariutti, A. Z. Mercadante, D. S. de Ávila, and C. C. Denardin. 2018. Purple pitanga fruit (Eugenia uniflora L.) protects against oxidative stress and increase the lifespan in Caenorhabditis elegans via the DAF-16/FOXO pathway. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 120:639–50. doi: 10.1016/j.fct.2018.07.057.
   PubMed Web of Science ®Google Scholar
• Tan, J. B. L, and Y. Y. Lim. 2015. Critical analysis of current methods for assessing the in vitro antioxidant and antibacterial activity of plant extracts. Food Chemistry 172:814–22.
   PubMed Web of Science ®Google Scholar
• Thilavech, T., S. Ngamukote, D. Belobrajdic, M. Abeywardena, and S. Adisakwattana. 2016. Cyanidin-3-rutinoside attenuates methylglyoxal-induced protein glycation and DNA damage via carbonyl trapping ability and scavenging reactive oxygen species. BMC Complementary and Alternative Medicine 16 (1):1–10. doi: 10.1186/s12906-016-1133-x.
   PubMedGoogle Scholar
• Tullet, J. M., M. Hertweck, J. H. An, J. Baker, J. Y. Hwang, S. Liu, R. P. Oliveira, R. Baumeister, and T. K. Blackwell. 2008. Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 132 (6):1025–38. doi: 10.1016/j.cell.2008.01.030.
   PubMed Web of Science ®Google Scholar
• van de Klashorst, D., A. van den Elzen, J. Weeteling, M. Roberts, T. Desai, L. Bottoms, and S. Hughes. 2020. Montmorency tart cherry (Prunus cerasus L.) acts as a calorie restriction mimetic that increases intestinal fat and lifespan in Caenorhabditis elegans. Journal of Functional Foods 68:103890. doi: 10.1016/j.jff.2020.103890.
   Web of Science ®Google Scholar
• Wang, B., Y. Xu, L. Chen, G. Zhao, Z. Mi, D. Lv, and J. Niu. 2020. Optimizing the extraction of polysaccharides from Bletilla ochracea Schltr. using response surface methodology (RSM) and evaluating their antioxidant activity. Processes 8 (3):341. doi: 10.3390/pr8030341.
   Web of Science ®Google Scholar
• Wang, D., T. Zou, Y. Yang, X. Yan, and W. Ling. 2011. Cyanidin-3-O-β-glucoside with the aid of its metabolite protocatechuic acid, reduces monocyte infiltration in apolipoprotein E-deficient mice. Biochemical Pharmacology 82 (7):713–9. doi: 10.1016/j.bcp.2011.04.007.
   PubMed Web of Science ®Google Scholar
• Wang, L., Y. M. Li, L. Lei, Y. Liu, X. Wang, K. Y. Ma, C. Zhang, H. Zhu, Y. Zhao, and Z.-Y. Chen. 2016. Purple sweet potato anthocyanin attenuates fat-induced mortality in Drosophila melanogaster. Experimental Gerontology 82:95–103.
   PubMed Web of Science ®Google Scholar
• Wang, Y., H. Wang, T. Ma, G. Liu, X. Feng, X. Liu, X. Ma, S. Liu, D. Shi, and B. Wang. 2022. Hawthorn extract inhibited the PI3k/Akt pathway to prolong the lifespan of Drosophila melanogaster. Journal of Food Biochemistry :e14169.
   PubMed Web of Science ®Google Scholar
• Wang, Z., L. Sun, Z. Fang, T. Nisar, L. Zou, D. Li, and Y. Guo. 2021. Lycium ruthenicum Murray anthocyanins effectively inhibit α-glucosidase activity and alleviate insulin resistance. Food Bioscience 41:100949. doi: 10.1016/j.fbio.2021.100949.
   Web of Science ®Google Scholar
• Xiong, L., N. Deng, B. Zheng, T. Li, and R. H. Liu. 2021. HSF-1 and SIR-2.1 linked insulin-like signaling is involved in goji berry (Lycium spp.) extracts promoting lifespan extension of Caenorhabditis elegans. Food & Function 12 (17):7851–66. doi: 10.1039/d0fo03300f.
   PubMed Web of Science ®Google Scholar
• Xue, F., X. Li, L. Qin, X. Liu, C. Li, and B. Adhikari. 2021. Anti-aging properties of phytoconstituents and phyto-nanoemulsions and their application in managing aging-related diseases. Advanced Drug Delivery Reviews 176:113886.
   PubMed Web of Science ®Google Scholar
• Yan, F., Y. Chen, R. Azat, and X. Zheng. 2017. Mulberry anthocyanin extract ameliorates oxidative damage in HepG2 cells and prolongs the lifespan of Caenorhabditis elegans through MAPK and Nrf2 pathways. Oxidative Medicine and Cellular Longevity 2017:1–12. doi: 10.1155/2017/7956158.
   Web of Science ®Google Scholar
• Yan, F., X. Chen, and X. Zheng. 2017. Protective effect of mulberry fruit anthocyanin on human hepatocyte cells (LO2) and Caenorhabditis elegans under hyperglycemic conditions. Food Research International (Ottawa, Ont.) 102:213–24.
   PubMed Web of Science ®Google Scholar
• Yan, Y., Y. Peng, J. Tang, J. Mi, L. Lu, X. Li, L. Ran, X. Zeng, and Y. Cao. 2018. Effects of anthocyanins from the fruit of Lycium ruthenicum Murray on intestinal microbiota. Journal of Functional Foods 48:533–41. doi: 10.1016/j.jff.2018.07.053.
   Web of Science ®Google Scholar
• Zhang, G., J. Li, S. Purkayastha, Y. Tang, H. Zhang, Y. Yin, B. Li, G. Liu, and D. Cai. 2013. Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH. Nature 497 (7448):211–6. doi: 10.1038/nature12143.
   PubMed Web of Science ®Google Scholar
• Zhang, H., Y. I. Hassan, J. Renaud, R. Liu, C. Yang, Y. Sun, and R. Tsao. 2017. Bioaccessibility, bioavailability, and anti‐inflammatory effects of anthocyanins from purple root vegetables using mono‐and co‐culture cell models. Molecular Nutrition & Food Research 61 (10):1600928. doi: 10.1002/mnfr.201600928.
   Web of Science ®Google Scholar
• Zhang, N., S. Jiao, and P. Jing. 2021. Red cabbage rather than green cabbage increases stress resistance and extends the lifespan of Caenorhabditis elegans. Antioxidants 10 (6):930. doi: 10.3390/antiox10060930.
   Web of Science ®Google Scholar
• Zhang, Q, and E. G. de Mejia. 2020. Protocatechuic acid attenuates adipogenesis-induced inflammation and mitochondrial dysfunction in 3T3-L1 adipocytes by regulation of AMPK pathway. Journal of Functional Foods 69:103972. doi: 10.1016/j.jff.2020.103972.
   Web of Science ®Google Scholar
• Zhang, W., L. Chen, Y. Xiong, A. C. Panayi, A. Abududilibaier, Y. Hu, C. Yu, W. Zhou, Y. Sun, and M. Liu. 2021. Antioxidant therapy and antioxidant-related bionanomaterials in diabetic wound healing. Frontiers in Bioengineering and Biotechnology 9:554.
   Web of Science ®Google Scholar
• Zhang, X., G. F. Shi, X. Z, Liu, L. J. An, and S. Guan. 2011. Anti‐ageing effects of protocatechuic acid from Alpinia on spleen and liver antioxidative system of senescent mice. Cell Biochemistry and Function 29 (4):342–7. doi: 10.1002/cbf.1757.
   PubMed Web of Science ®Google Scholar
• Zhang, X., H. Wang, Y. Han, Y. Pei, Y. Guo, and S. W. Cui. 2021. Purple sweet potato extract maintains intestinal homeostasis and extend lifespan through increasing autophagy in female Drosophila melanogaster. Journal of Food Biochemistry 45 (8):e13861. doi: 10.1111/jfbc.13861.
   Web of Science ®Google Scholar
• Zhao, J., J. Yu, Q. Zhi, T. Yuan, X. Lei, K. Zeng, and J. Ming. 2021. Anti-aging effects of the fermented anthocyanin extracts of purple sweet potato on Caenorhabditis elegans. Food & Function 12 (24):12647–58. doi: 10.1039/d1fo02671b.
   PubMed Web of Science ®Google Scholar
• Zhou, H., S. Ding, C. Sun, J. Fu, D. Yang, X. E. Wang, C.-C. Wang, and L. Wang. 2021. Lycium barbarum extracts extend lifespan and alleviate proteotoxicity in Caenorhabditis elegans. Frontiers in Nutrition 8:815947. doi: 10.3389/fnut.2021.815947.
   PubMed Web of Science ®Google Scholar
• Zhou, L., H. Wang, J. Yi, B. Yang, M. Li, D. He, W. Yang, Y. Zhang, and H. Ni. 2018. Anti-tumor properties of anthocyanins from Lonicera caerulea ‘Beilei’fruit on human hepatocellular carcinoma: In vitro and in vivo study. Biomedicine & Pharmacotherapy = Biomedecine & pharmacotherapie 104:520–9. doi: 10.1016/j.biopha.2018.05.057.
   PubMed Web of Science ®Google Scholar
• Zhou, L., M. Xie, F. Yang, and J. Liu. 2020. Antioxidant activity of high purity blueberry anthocyanins and the effects on human intestinal microbiota. LWT 117:108621. doi: 10.1016/j.lwt.2019.108621.
   Web of Science ®Google Scholar
• Zou, T.-B., D. Feng, G. Song, H.-W. Li, H.-W. Tang, and W.-H. Ling. 2014. The role of sodium-dependent glucose transporter 1 and glucose transporter 2 in the absorption of cyanidin-3-O-β-glucoside in Caco-2 cells. Nutrients 6 (10):4165–77. doi: 10.3390/nu6104165.
   PubMed Web of Science ®Google Scholar
• Zuo, Y., C. Peng, Y. Liang, K. Y. Ma, H. Yu, H. Y. E. Chan, and Z.-Y. Chen. 2012. Black rice extract extends the lifespan of fruit flies. Food & Function 3 (12):1271–9. doi: 10.1039/c2fo30135k.
   PubMed Web of Science ®Google Scholar