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Review Articles

Garlic (Allium sativum L.) in diabetes and its complications: Recent advances in mechanisms of action

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References

  • Abdel-Mageid, A. D., M. E. S. Abou-Salem, N. Salaam, and H. A. S. El-Garhy. 2018. The potential effect of garlic extract and curcumin nanoparticles against complication accompanied with experimentally induced diabetes in rats. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 43:126–34. doi: 10.1016/j.phymed.2018.04.039.
  • Abdul-Ghani, M., and R. A. DeFronzo. 2021. Insulin resistance and hyperinsulinemia: The egg and the chicken. The Journal of Clinical Endocrinology & Metabolism 106 (4):e1897–e99. doi: 10.1210/clinem/dgaa364.
  • Abdullah, R. I., A. A. Allah, A. S. Mubarak, R. I. Abdullah, S. H. Alzhrani, M. H. Alsufyani, S. J. A. Alharthi, and R. O. H. Althomali. 2020. Prevalence and predictors of using complementary and alternative medicine among diabetic patients in Taif city, Saudi Arabia. Journal of Family Medicine and Primary Care 9 (4):2092–8. doi: 10.4103/jfmpc.jfmpc_1222_19.
  • Abdultawab, H. S., and N. N. Ayuob. 2013. Can garlic oil ameliorate diabetes-induced oxidative stress in a rat liver model? A correlated histological and biochemical study. Food and Chemical Toxicology 59:650–6. doi: 10.1016/j.fct.2013.07.009.
  • Abe, K., Y. Hori, and T. Myoda. 2020. Volatile compounds of fresh and processed garlic. Experimental and Therapeutic Medicine 19:1585–93.
  • Abel-Salam, B. K. 2012. Immunomodulatory effects of black seeds and garlic on alloxan-induced Diabetes in albino rat. Allergologia et Immunopathologia 40 (6):336–40. doi: 10.1016/j.aller.2011.07.002.
  • Ademiluyi, A. O., G. Oboh, T. R. Owoloye, and O. J. Agbebi. 2013. Modulatory effects of dietary inclusion of garlic (Allium sativum) on gentamycin-induced hepatotoxicity and oxidative stress in rats. Asian Pacific Journal of Tropical Biomedicine 3 (6):470–5. doi: 10.1016/S2221-1691(13)60098-2.
  • Afkarian, M., M. C. Sachs, B. Kestenbaum, I. B. Hirsch, K. R. Tuttle, J. Himmelfarb, and I. H. de Boer. 2013. Kidney disease and increased mortality risk in type 2 diabetes. Journal of the American Society of Nephrology: JASN 24 (2):302–8. doi: 10.1681/ASN.2012070718.
  • Ahmed, T., and C. K. Wang. 2021. Black garlic and its bioactive compounds on human health diseases: A review. Molecules 26 (16):5028. doi: 10.3390/molecules26165028.
  • Ahmed, U., S. Khaliq, H. U. Ahmad, I. Ahmad, U. A. Ashfaq, M. Qasim, and M. S. Masoud. 2021. Pathogenesis of diabetic cardiomyopathy and role of miRNA. Critical Reviews in Eukaryotic Gene Expression 31 (1):79–92. doi: 10.1615/CritRevEukaryotGeneExpr.2021037533.
  • Al-Malki, A. L. 2016. Inhibition of α-glucosidase by thiosulfinate as a target for glucose modulation in diabetic rats. Evidence-Based Complementary and Alternative Medicine: eCAM 2016:7687915. doi: 10.1155/2016/7687915.
  • Al-Mrabeh, A. 2020. Pathogenesis and remission of type 2 diabetes: What has the twin cycle hypothesis taught us? Cardiovascular Endocrinology & Metabolism 9 (4):132–42. doi: 10.1097/XCE.0000000000000201.
  • Al-Qattan, K. K., M. H. Mansour, M. Thomson, and M. Ali. 2016. Garlic decreases liver and kidney receptor for advanced glycation end products expression in experimental diabetes. Pathophysiology 23 (2):135–45. doi: 10.1016/j.pathophys.2016.02.003.
  • Al-Qattan, K. K., M. Thomson, M. Ali, and M. H. Mansour. 2013. Garlic (Allium sativum) attenuate glomerular glycation in streptozotocin-induced diabetic rats: A possible role of insulin. Pathophysiology 20 (2):147–52. doi: 10.1016/j.pathophys.2013.04.001.
  • Al-Qattan, K. K., M. Thomson, D. Jayasree, and M. Ali. 2016. Garlic attenuates plasma and kidney ACE-1 and AngII modulations in early streptozotocin-induced diabetic rats: Renal clearance and blood pressure implications. Evidence-Based Complementary and Alternative Medicine: eCAM 2016:8142394. doi: 10.1155/2016/8142394.
  • Alicic, R. Z., M. T. Rooney, and K. R. Tuttle. 2017. Diabetic kidney disease: Challenges, progress, and possibilities. Clinical Journal of the American Society of Nephrology: CJASN 12 (12):2032–45. doi: 10.2215/CJN.11491116.
  • Amagase, H., B. L. Petesch, H. Matsuura, S. Kasuga, and Y. Itakura. 2001. Intake of garlic and its bioactive components. The Journal of Nutrition 131 (3s):955s–62s. doi: 10.1093/jn/131.3.955S.
  • Amor, S., D. González-Hedström, B. Martín-Carro, A. M. Inarejos-García, P. Almodóvar, M. Prodanov, A. L. García-Villalón, and M. Granado. 2019. Beneficial effects of an aged black garlic extract in the metabolic and vascular alterations induced by a high fat/sucrose diet in male rats. Nutrients 11 (1):153. doi: 10.3390/nu11010153.
  • Ansary, J., T. Y. Forbes-Hernández, E. Gil, D. Cianciosi, J. Zhang, M. Elexpuru-Zabaleta, J. Simal-Gandara, F. Giampieri, and M. Battino. 2020. Potential health benefit of garlic based on human intervention studies: A brief overview. Antioxidants (Basel) 9 (7):619. doi: 10.3390/antiox9070619.
  • Arab Sadeghabadi, Z., N. Ziamajidi, R. Abbasalipourkabir, and R. Mohseni. 2018. Garlic (Allium sativum) increases SIRT1 and SIRT2 gene expressions in the kidney and liver tissues of STZ- and STZ + niacinamide-induced diabetic rats. Journal of Basic and Clinical Physiology and Pharmacology 29 (5):463–7. doi: 10.1515/jbcpp-2017-0079.
  • Arellano-Buendía, A. S., L. G. Castañeda-Lara, M. L. Loredo-Mendoza, F. E. García-Arroyo, P. Rojas-Morales, R. Argüello-García, J. G. Juárez-Rojas, E. Tapia, J. Pedraza-Chaverri, L. G. Sánchez-Lozada, et al. 2020. Effects of allicin on pathophysiological mechanisms during the progression of nephropathy associated to diabetes. Antioxidants (Basel) 9 (11):1134. doi: 10.3390/antiox9111134.
  • Armstrong, D. G., and L. A. Lavery. 1998. Diabetic foot ulcers: Prevention, diagnosis and classification. American Family Physician 57 (6):1325–32.
  • Asdaq, S. M. B., S. Lokaraja, A. S. Alamri, W. F. Alsanie, M. Alhomrani, A. H. Almutiri, S. Nagaraja, and M. Imran. 2021. Potential interaction of fresh garlic with metformin during ischemia-reperfusion induced cardiac injury in diabetic rats. Evidence-Based Complementary and Alternative Medicine: eCAM 2021:9739089. doi: 10.1155/2021/9739089.
  • Ashraf, R., R. A. Khan, and I. Ashraf. 2011. Garlic (Allium sativum) supplementation with standard antidiabetic agent provides better diabetic control in type 2 diabetes patients. Pakistan Journal of Pharmaceutical Sciences 24 (4):565–70.
  • Atkin, M., D. Laight, and M. H. Cummings. 2016. The effects of garlic extract upon endothelial function, vascular inflammation, oxidative stress and insulin resistance in adults with type 2 diabetes at high cardiovascular risk. A pilot double blind randomized placebo controlled trial. Journal of Diabetes and Its Complications 30 (4):723–7. doi: 10.1016/j.jdiacomp.2016.01.003.
  • Atlas, S. A. 2007. The renin-angiotensin aldosterone system: Pathophysiological role and pharmacologic inhibition. Journal of Managed Care Pharmacy: JMCP 13 (8 Suppl B):9–20. doi: 10.18553/jmcp.2007.13.s8-b.9.
  • Awan, K. A., M. S. Butt, F. Ashfaq, H. Munir, and H. A. R. Suleria. 2019. Prophylactic potential of conventional and supercritical garlic extracts to alleviate diet related malfunctions. Recent Patents on Food, Nutrition & Agriculture 10 (1):34–47. doi: 10.2174/2212798410666180724103827.
  • Awan, N. M., I. J. Meurling, and D. O’Shea. 2021. Understanding obesity: The role of adipose tissue microenvironment and the gut microbiome. Saudi Journal of Medicine & Medical Sciences 9 (1):10–5. doi: 10.4103/sjmms.sjmms_561_20.
  • Ayo, S. H., R. Radnik, J. A. Garoni, D. A. Troyer, and J. I. Kreisberg. 1991. High glucose increases diacylglycerol mass and activates protein kinase C in mesangial cell cultures. The American Journal of Physiology 261 (4 Pt 2):F571–7. doi: 10.1152/ajprenal.1991.261.4.F571.
  • Bae, S. E., S. Y. Cho, Y. D. Won, S. H. Lee, and H. J. Park. 2014. Changes in S-allyl cysteine contents and physicochemical properties of black garlic during heat treatment. LWT - Food Science and Technology 55 (1):397–402. doi: 10.1016/j.lwt.2013.05.006.
  • Bahramsoltani, R., M. H. Farzaei, M. Ram, S. Nikfar, and R. Rahimi. 2021. Bioactive foods and medicinal plants for cardiovascular complications of type II diabetes: Current clinical evidence and future perspectives. Evidence-Based Complementary and Alternative Medicine: eCAM 2021:6681540. doi: 10.1155/2021/6681540.
  • Bailey, C. J., and C. Day. 2018. Treatment of type 2 diabetes: Future approaches. British Medical Bulletin 126 (1):123–37. doi: 10.1093/brimed/ldy013.
  • Baluchnejadmojarad, T., Z. Kiasalari, S. Afshin-Majd, Z. Ghasemi, and M. Roghani. 2017. S-allyl cysteine ameliorates cognitive deficits in streptozotocin-diabetic rats via suppression of oxidative stress, inflammation, and acetylcholinesterase. European Journal of Pharmacology 794:69–76. doi: 10.1016/j.ejphar.2016.11.033.
  • Bar, M., U. E. Binduga, and K. A. Szychowski. 2022. Methods of isolation of active substances from garlic (Allium sativum L.) and its impact on the composition and biological properties of garlic extracts. Antioxidants (Basel) 11 (7):1345. doi: 10.3390/antiox11071345.
  • Barkaoui, M., A. Katiri, H. Boubaker, and F. Msanda. 2017. Ethnobotanical survey of medicinal plants used in the traditional treatment of diabetes in Chtouka Ait Baha and Tiznit (Western Anti-Atlas), Morocco. Journal of Ethnopharmacology 198:338–50. doi: 10.1016/j.jep.2017.01.023.
  • Bastaki, S., M. A. S. Ojha, H. Kalasz, and E. Adeghate. 2021. Chemical constituents and medicinal properties of Allium species. Molecular and Cellular Biochemistry 476 (12):4301–21. doi: 10.1007/s11010-021-04213-2.
  • Behrouj, H., N. Ziamajidi, R. Abbasalipourkabir, M. T. Goodarzi, and M. Saidijam. 2018. Hypoglycemic and antioxidant effects of oral administration of garlic extract in the livers of type 1 diabetic rats. Journal of Basic and Clinical Physiology and Pharmacology 30 (2):245–50. doi: 10.1515/jbcpp-2018-0124.
  • Bhattacharya, S., U. Maji, G. A. Khan, R. Das, A. K. Sinha, C. Ghosh, and S. Maiti. 2019. Antidiabetic role of a novel protein from garlic via NO in expression of Glut-4/insulin in liver of alloxan induced diabetic mice. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 111:1302–14. doi: 10.1016/j.biopha.2019.01.036.
  • Bhattacharya, S., L. Nagendra, A. Krishnamurthy, O. J. Lakhani, N. Kapoor, B. Kalra, and S. Kalra. 2021. Early gestational diabetes mellitus: Diagnostic strategies and clinical implications. Medical Sciences (Basel) 9 (4):59. doi: 10.3390/medsci9040059.
  • Biessels, G. J., and R. A. Whitmer. 2020. Cognitive dysfunction in diabetes: How to implement emerging guidelines. Diabetologia 63 (1):3–9. doi: 10.1007/s00125-019-04977-9.
  • Biró, A., A. Markovics, M. É. Fazekas, G. Fidler, G. Szalóki, M. Paholcsek, J. Lukács, L. Stündl, and J. Remenyik. 2020. Allithiamine alleviates hyperglycaemia-induced endothelial dysfunction. Nutrients 12 (6):1690. doi: 10.3390/nu12061690.
  • Blahova, J., M. Martiniakova, M. Babikova, V. Kovacova, V. Mondockova, and R. Omelka. 2021. Pharmaceutical drugs and natural therapeutic products for the treatment of type 2 diabetes mellitus. Pharmaceuticals (Basel) 14 (8):806. doi: 10.3390/ph14080806.
  • Block, E. 1985. The chemistry of garlic and onions. Scientific American 252 (3):114–9. doi: 10.1038/scientificamerican0385-114.
  • Bódis, K., and M. Roden. 2018. Energy metabolism of white adipose tissue and insulin resistance in humans. European Journal of Clinical Investigation 48 (11):e13017. doi: 10.1111/eci.13017.
  • Boyd, K. A., D. G. O’Donovan, S. Doran, J. Wishart, I. M. Chapman, M. Horowitz, and C. Feinle. 2003. High-fat diet effects on gut motility, hormone, and appetite responses to duodenal lipid in healthy men. American Journal of Physiology. Gastrointestinal and Liver Physiology 284 (2):G188–96. doi: 10.1152/ajpgi.00375.2002.
  • Brahmanaidu, P., V. V. S. Uddandrao, V. Sasikumar, R. R. Naik, S. Pothani, M. S. Begum, M. P. Rajeshkumar, C. Varatharaju, B. Meriga, P. Rameshreddy, et al. 2017. Reversal of endothelial dysfunction in aorta of streptozotocin-nicotinamide-induced type-2 diabetic rats by S-Allylcysteine. Molecular and Cellular Biochemistry 432 (1-2):25–32. doi: 10.1007/s11010-017-2994-0.
  • Brocco, E., S. Ninkovic, M. Marin, C. Whisstock, M. Bruseghin, G. Boschetti, R. Viti, W. Forlini, and A. Volpe. 2018. Diabetic foot management: Multidisciplinary approach for advanced lesion rescue. The Journal of Cardiovascular Surgery 59 (5):670–84. doi: 10.23736/S0021-9509.18.10606-9.
  • Bugger, H., and E. D. Abel. 2014. Molecular mechanisms of diabetic cardiomyopathy. Diabetologia 57 (4):660–71. doi: 10.1007/s00125-014-3171-6.
  • Burgess, J. L., W. A. Wyant, B. Abdo Abujamra, R. S. Kirsner, and I. Jozic. 2021. Diabetic wound-healing science. Medicina (Kaunas) 57 (10):1072. doi: 10.3390/medicina57101072.
  • Cahová, M., H. Vavřínková, and L. Kazdová. 2007. Glucose-fatty acid interaction in skeletal muscle and adipose tissue in insulin resistance. Physiological Research 56 (1):1–15. doi: 10.33549/physiolres.930882.
  • Cai, J., H. Guan, X. Jiao, J. Yang, X. Chen, H. Zhang, Y. Zheng, Y. Zhu, Q. Liu, and Z. Zhang. 2021. NLRP3 inflammasome mediated pyroptosis is involved in cadmium exposure-induced neuroinflammation through the IL-1β/IkB-α-NF-κB-NLRP3 feedback loop in swine. Toxicology 453:152720. doi: 10.1016/j.tox.2021.152720.
  • Cannon, B., and J. Nedergaard. 2004. Brown adipose tissue: Function and physiological significance. Physiological Reviews 84 (1):277–359. doi: 10.1152/physrev.00015.2003.
  • Carré, J. E., and C. Affourtit. 2019. Mitochondrial activity and skeletal muscle insulin resistance in kidney disease. International Journal of Molecular Sciences 20 (11):2751. doi: 10.3390/ijms20112751.
  • Castela, Â., and C. Costa. 2016. Molecular mechanisms associated with diabetic endothelial-erectile dysfunction. Nature Reviews. Urology 13 (5):266–74. doi: 10.1038/nrurol.2016.23.
  • Chang, S. H., C. J. Liu, C. H. Kuo, H. Chen, W. Y. Lin, K. Y. Teng, S. W. Chang, C. H. Tsai, F. J. Tsai, C. Y. Huang, et al. 2011. Garlic oil alleviates MAPKs- and IL-6-mediated diabetes-related cardiac hypertrophy in STZ-induced DM rats. Evidence-Based Complementary and Alternative Medicine: eCAM 2011:950150. doi: 10.1093/ecam/neq075.
  • Chao, P. C., Y. Li, C. H. Chang, J. P. Shieh, J. T. Cheng, and K. C. Cheng. 2018. Investigation of insulin resistance in the popularly used four rat models of type-2 diabetes. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 101:155–61. doi: 10.1016/j.biopha.2018.02.084.
  • Charron, M. J., E. B. Katz, and J. R. Zierath. 1997. Metabolic and molecular consequences of modifying GLUT4 expression in skeletal muscle. Biochemical Society Transactions 25 (3):963–8. doi: 10.1042/bst0250963.
  • Chen, C., R. Li, R. S. Ross, and A. M. Manso. 2016. Integrins and integrin-related proteins in cardiac fibrosis. Journal of Molecular and Cellular Cardiology 93:162–74. doi: 10.1016/j.yjmcc.2015.11.010.
  • Chen, Q. M. 2022. Nrf2 for protection against oxidant generation and mitochondrial damage in cardiac injury. Free Radical Biology & Medicine 179:133–43. doi: 10.1016/j.freeradbiomed.2021.12.001.
  • Cheng, Z., V. N. Garikipati, E. Nickoloff, C. Wang, D. J. Polhemus, J. Zhou, C. Benedict, M. Khan, S. K. Verma, J. E. Rabinowitz, et al. 2016. Restoration of hydrogen sulfide production in diabetic mice improves reparative function of bone marrow cells. Circulation 134 (19):1467–83. doi: 10.1161/CIRCULATIONAHA.116.022967.
  • Choi, I. S., H. S. Cha, and Y. S. Lee. 2014. Physicochemical and antioxidant properties of black garlic. Molecules 19 (10):16811–23. doi: 10.3390/molecules191016811.
  • Choudhary, P. R., R. D. Jani, and M. S. Sharma. 2018. Effect of raw crushed garlic (Allium sativum L.) on components of metabolic syndrome. Journal of Dietary Supplements 15 (4):499–506. doi: 10.1080/19390211.2017.1358233.
  • Cicero, A. F., G. Derosa, and A. Gaddi. 2004. What do herbalists suggest to diabetic patients in order to improve glycemic control? Evaluation of scientific evidence and potential risks. Acta Diabetologica 41 (3):91–8. doi: 10.1007/s00592-004-0150-2.
  • Consoli, V., V. Sorrenti, S. Grosso, and L. Vanella. 2021. Heme oxygenase-1 signaling and redox homeostasis in physiopathological conditions. Biomolecules 11 (4):589. doi: 10.3390/biom11040589.
  • Coustan, D. R. 2013. Gestational diabetes mellitus. Clinical Chemistry 59 (9):1310–21. doi: 10.1373/clinchem.2013.203331.
  • de Boer, I. H., T. C. Rue, Y. N. Hall, P. J. Heagerty, N. S. Weiss, and J. Himmelfarb. 2011. Temporal trends in the prevalence of diabetic kidney disease in the United States. JAMA 305 (24):2532–9. doi: 10.1001/jama.2011.861.
  • Deacon, C. F. 2020. Dipeptidyl peptidase 4 inhibitors in the treatment of type 2 diabetes mellitus. Nature Reviews Endocrinology 16 (11):642–53. doi: 10.1038/s41574-020-0399-8.
  • Dillmann, W. H. 2019. Diabetic cardiomyopathy. Circulation Research 124 (8):1160–2. doi: 10.1161/CIRCRESAHA.118.314665.
  • Ding, Z. J., and P. Chen. 2015. Protective effects and mechanism of allitridi on the diabetic rats induced by STZ. Pharmacology and Clinics of Chinese Materia Medica 31:10–3.
  • Ding, Z. J., and P. Chen. 2017. Protective effects of allitridi on testis tissue injury in type 2 diabetic rats. Journal of Liaoning University of TCM 19:51–4.
  • Dixit, V. P., and S. Joshi. 1982. Effects of chronic administration of garlic (Allium sativum Linn) on testicular function. Indian Journal of Experimental Biology 20 (7):534–6.
  • Drobiova, H., M. Thomson, K. Al-Qattan, R. Peltonen-Shalaby, Z. Al-Amin, and M. Ali. 2011. Garlic increases antioxidant levels in diabetic and hypertensive rats determined by a modified peroxidase method. Evidence-Based Complementary and Alternative Medicine: eCAM 2011:703049. doi: 10.1093/ecam/nep011.
  • Drzewoski, J., J. Kasznicki, and Z. Trojanowski. 2009. The role of "metabolic memory" in the natural history of diabetes mellitus. Polskie Archiwum Medycyny Wewnetrznej 119 (7–8):493–500.
  • El-Saber Batiha, G., A. Magdy Beshbishy, G. Wasef, L. Y. H. A. Elewa, A. Al-Sagan, A. M. E. Abd El-Hack, A. E. Taha, M. Abd-Elhakim, Y, and H. Prasad Devkota. 2020. Chemical constituents and pharmacological activities of garlic (Allium sativum L.): A review. Nutrients 12 (3):872. doi: 10.3390/nu12030872.
  • Elosta, A., M. Slevin, K. Rahman, and N. Ahmed. 2017. Aged garlic has more potent antiglycation and antioxidant properties compared to fresh garlic extract in vitro. Scientific Reports 7:39613. doi: 10.1038/srep39613.
  • Eser, N., A. Yoldas, A. Turk, A. Kalaycı Yigin, A. Yalcin, and M. Cicek. 2021. Ameliorative effects of garlic oil on FNDC5 and irisin sensitivity in liver of streptozotocin-induced diabetic rats. The Journal of Pharmacy and Pharmacology 73 (6):824–34. doi: 10.1093/jpp/rgab023.
  • Eshed, I., A. Elis, and M. Lishner. 2001. Plasma ferritin and type 2 diabetes mellitus: A critical review. Endocrine Research 27 (1–2):91–7. doi: 10.1081/erc-100107172.
  • Fehresti Sani, M., S. Montasser Kouhsari, and L. Moradabadi. 2012. Effects of three medicinal plants extracts in experimental diabetes: Antioxidant enzymes activities and plasma lipids profiles in comparison with metformin. Iranian Journal of Pharmaceutical Research: IJPR 11 (3):897–903.
  • Feng, B., S. Chen, J. Chiu, B. George, and S. Chakrabarti. 2008. Regulation of cardiomyocyte hypertrophy in diabetes at the transcriptional level. American Journal of Physiology. Endocrinology and Metabolism 294 (6):E1119–26. doi: 10.1152/ajpendo.00029.2008.
  • Ferner, R. E., and S. Chaplin. 1987. The relationship between the pharmacokinetics and pharmacodynamic effects of oral hypoglycaemic drugs. Clinical Pharmacokinetics 12 (6):379–401. doi: 10.2165/00003088-198712060-00001.
  • Fista, G. A., J. G. Bloukas, and A. S. Siomos. 2004. Effect of leek and onion on processing and quality characteristics of Greek traditional sausages. Meat Science 68 (2):163–72. doi: 10.1016/j.meatsci.2004.02.005.
  • Friedman, J. M., and J. L. Halaas. 1998. Leptin and the regulation of body weight in mammals. Nature 395 (6704):763–70. doi: 10.1038/27376.
  • Friedrichsen, M., B. Mortensen, C. Pehmøller, J. B. Birk, and J. F. Wojtaszewski. 2013. Exercise-induced AMPK activity in skeletal muscle: Role in glucose uptake and insulin sensitivity. Molecular and Cellular Endocrinology 366 (2):204–14. doi: 10.1016/j.mce.2012.06.013.
  • Fujita, Y., A. T. Cheung, and T. J. Kieffer. 2004. Harnessing the gut to treat diabetes. Pediatric Diabetes, 5(Suppl 2):57–69.
  • Fünfstück, R., L. E. Nicolle, M. Hanefeld, and K. G. Naber. 2012. Urinary tract infection in patients with diabetes mellitus. Clinical Nephrology 77 (1):40–8. doi: 10.5414/cn107216.
  • Gao, H., and G. Huang. 2019. Preparation and antioxidant activity of carboxymethylated garlic polysaccharide. International Journal of Biological Macromolecules 121:650–4. doi: 10.1016/j.ijbiomac.2018.10.094.
  • Gao, Y. C., C. Q. Xu, X. Y. Liu, B. Xiao, and S. T. Liu. 2011. Effect of different doses of allicin on the comparison of diabetic rat arrhythmia. Journal of Qiqihar University of Medicine 32:1033–4.
  • Garg, S. S., and J. Gupta. 2022. Polyol pathway and redox balance in diabetes. Pharmacological Research 182:106326. doi: 10.1016/j.phrs.2022.106326.
  • Ghotaslou, R., M. Y. Memar, and N. Alizadeh. 2018. Classification, microbiology and treatment of diabetic foot infections. Journal of Wound Care 27 (7):434–41. doi: 10.12968/jowc.2018.27.7.434.
  • Giacoman-Martínez, A., F. J. Alarcón-Aguilar, A. Zamilpa, F. Huang, R. Romero-Nava, R. Román-Ramos, and J. C. Almanza-Pérez. 2021. α-Amyrin induces GLUT4 translocation mediated by AMPK and PPARδ/γ in C2C12 myoblasts. Canadian Journal of Physiology and Pharmacology 99 (9):935–42. doi: 10.1139/cjpp-2021-0027.
  • Gifford, C. C., J. Tang, A. Costello, N. S. Khakoo, T. Q. Nguyen, R. Goldschmeding, P. J. Higgins, and R. Samarakoon. 2021. Negative regulators of TGF-β1 signaling in renal fibrosis; pathological mechanisms and novel therapeutic opportunities. Clinical Science (London, England: 1979) 135 (2):275–303. doi: 10.1042/CS20201213.
  • Giorgi, C., S. Marchi, I. C. M. Simoes, Z. Ren, G. Morciano, M. Perrone, P. Patalas-Krawczyk, S. Borchard, P. Jędrak, K. Pierzynowska, et al. 2018. Mitochondria and reactive oxygen species in aging and age-related diseases. International Review of Cell and Molecular Biology 340:209–344. doi: 10.1016/bs.ircmb.2018.05.006.
  • Giribabu, N., N. Srinivasarao, S. Swapna Rekha, S. Muniandy, and N. Salleh. 2014. Centella asiatica attenuates diabetes induced hippocampal changes in experimental diabetic rats. Evidence-Based Complementary and Alternative Medicine: eCAM 2014:592062. doi: 10.1155/2014/592062.
  • Glass, E. J., J. Stewart, and D. M. Weir. 1986. Altered immune function in alloxan-induced diabetes in mice. Clinical and Experimental Immunology 65 (3):614–21.
  • González-Domínguez, Á., F. M. Visiedo-García, J. Domínguez-Riscart, R. González-Domínguez, R. M. Mateos, and A. M. Lechuga-Sancho. 2020. Iron metabolism in obesity and metabolic syndrome. International Journal of Molecular Sciences 21 (15):5529. doi: 10.3390/ijms21155529.
  • Guo, H., H. Ding, Y. Yan, Q. Chen, J. Zhang, B. Chen, and J. Cao. 2021. Intermittent hypoxia-induced autophagy via AMPK/mTOR signaling pathway attenuates endothelial apoptosis and dysfunction in vitro. Sleep & Breathing = Schlaf & Atmung 25 (4):1859–65. doi: 10.1007/s11325-021-02297-0.
  • Hamal, S., L. Cherukuri, D. Birudaraju, S. Matsumoto, A. Kinninger, B. T. Chaganti, F. Flores, K. Shaikh, S. K. Roy, and M. J. Budoff. 2020. Short-term impact of aged garlic extract on endothelial function in diabetes: A randomized, double-blind, placebo-controlled trial. Experimental and Therapeutic Medicine 19:1485–9.
  • Hargreaves, M. 2015. Exercise, muscle, and CHO metabolism. Scandinavian Journal of Medicine & Science in Sports, 25 (Suppl 4):29–33.
  • Hartley, A., D. Haskard, and R. Khamis. 2019. Oxidized LDL and anti-oxidized LDL antibodies in atherosclerosis - Novel insights and future directions in diagnosis and therapy. Trends in Cardiovascular Medicine 29 (1):22–6. doi: 10.1016/j.tcm.2018.05.010.
  • Hattori, Y., E. B. Campbell, and S. S. Gross. 1994. Argininosuccinate synthetase mRNA and activity are induced by immunostimulants in vascular smooth muscle. Role in the regeneration or arginine for nitric oxide synthesis. The Journal of Biological Chemistry 269 (13):9405–8.
  • Hayashi, T., S. Takai, and C. Yamashita. 2010. Impact of the renin-angiotensin-aldosterone-system on cardiovascular and renal complications in diabetes mellitus. Current Vascular Pharmacology 8 (2):189–97. doi: 10.2174/157016110790886947.
  • Hayashida, T., M. Decaestecker, and H. W. Schnaper. 2003. Cross-talk between ERK MAP kinase and Smad signaling pathways enhances TGF-beta-dependent responses in human mesangial cells. FASEB Journal 17 (11):1576–8. doi: 10.1096/fj.03-0037fje.
  • Hfaiedh, N., J. C. Murat, and A. Elfeki. 2011. Compared ability of garlic (Allium sativum) extract or α-tocopherol + magnesium association to reduce metabolic disorders and oxidative stress in diabetic rats. Phytotherapy Research: PTR 25 (6):821–7. doi: 10.1002/ptr.3344.
  • Hosseini, A., and H. Hosseinzadeh. 2015. A review on the effects of Allium sativum (Garlic) in metabolic syndrome. Journal of Endocrinological Investigation 38 (11):1147–57. doi: 10.1007/s40618-015-0313-8.
  • Hou, L. Q., Y. H. Liu, and Y. Y. Zhang. 2015. Garlic intake lowers fasting blood glucose: Meta-analysis of randomized controlled trials. Asia Pacific Journal of Clinical Nutrition 24 (4):575–82. doi: 10.6133/apjcn.2015.24.4.15.
  • Hsieh, D. J., S. C. Ng, R. Y. Zeng, V. V. Padma, C. Y. Huang, and W. W. Kuo. 2020. Diallyl Trisulfide (DATS) suppresses AGE-induced cardiomyocyte apoptosis by targeting ROS-mediated PKCδ activation. International Journal of Molecular Sciences 21 (7):2608. doi: 10.3390/ijms21072608.
  • Hu, J. 2014. Effect of allicin on antioxidant in serum of diabetic rats. Journal of Hubei University of Science and Technology (Medical Sciences) 28:12–3.
  • Hu, X., T. Bai, Z. Xu, Q. Liu, Y. Zheng, and L. Cai. 2017. Pathophysiological fundamentals of diabetic cardiomyopathy. Comprehensive Physiology 7 (2):693–711. doi: 10.1002/cphy.c160021.
  • Huang, H., Y. Jiang, G. Mao, F. Yuan, H. Zheng, Y. Ruan, and T. Wu. 2017. Protective effects of allicin on streptozotocin-induced diabetic nephropathy in rats. Journal of the Science of Food and Agriculture 97 (4):1359–66. doi: 10.1002/jsfa.7874.
  • Huang, H., F. Zheng, X. Dong, F. Wu, T. Wu, and H. Li. 2017. Allicin inhibits tubular epithelial-myofibroblast transdifferentiation under high glucose conditions in vitro. Experimental and Therapeutic Medicine 13 (1):254–62. doi: 10.3892/etm.2016.3913.
  • Huang, W., Y. Wang, Y. G. Cao, H. P. Qi, L. Li, B. Bai, Y. Liu, and H. L. Sun. 2013. Antiarrhythmic effects and ionic mechanisms of allicin on myocardial injury of diabetic rats induced by streptozotocin. Naunyn-Schmiedeberg’s Archives of Pharmacology 386 (8):697–704. doi: 10.1007/s00210-013-0872-1.
  • Huang, Y. T., C. H. Yao, C. L. Way, K. W. Lee, C. Y. Tsai, H. C. Ou, and W. W. Kuo. 2013. Diallyl trisulfide and diallyl disulfide ameliorate cardiac dysfunction by suppressing apoptotic and enhancing survival pathways in experimental diabetic rats. Journal of Applied Physiology (Bethesda, MD: 1985) 114 (3):402–10. doi: 10.1152/japplphysiol.00672.2012.
  • Hutchins, E., K. Shaikh, A. Kinninger, L. Cherukuri, D. Birudaraju, S. S. Mao, R. Nakanishi, S. Almeida, E. Jayawardena, C. Shekar, et al. 2020. Aged garlic extract reduces left ventricular myocardial mass in patients with diabetes: A prospective randomized controlled double-blind study. Experimental and Therapeutic Medicine 19:1468–71.
  • Huynh, K., B. C. Bernardo, J. R. McMullen, and R. H. Ritchie. 2014. Diabetic cardiomyopathy: Mechanisms and new treatment strategies targeting antioxidant signaling pathways. Pharmacology & Therapeutics 142 (3):375–415. doi: 10.1016/j.pharmthera.2014.01.003.
  • Hyslop, C. M., S. Tsai, V. Shrivastava, P. Santamaria, and C. Huang. 2016. Prolactin as an adjunct for type 1 diabetes immunotherapy. Endocrinology 157 (1):150–65. doi: 10.1210/en.2015-1549.
  • Inchiostro, S. 2005. Measurement of insulin sensitivity in Type 2 diabetes mellitus: Comparison between KITT and HOMA-%S indices and evaluation of their relationship with the components of the insulin resistance syndrome. Diabetic Medicine 22 (1):39–44. doi: 10.1111/j.1464-5491.2004.01354.x.
  • Jang, H. J., H. J. Lee, D. K. Yoon, D. S. Ji, J. H. Kim, and C. H. Lee. 2018. Antioxidant and antimicrobial activities of fresh garlic and aged garlic by-products extracted with different solvents. Food Science and Biotechnology 27 (1):219–25. doi: 10.1007/s10068-017-0246-4.
  • Jeong, Y. Y., J. H. Ryu, J. H. Shin, M. J. Kang, J. R. Kang, J. Han, and D. Kang. 2016. Comparison of anti-oxidant and anti-inflammatory effects between fresh and aged black garlic extracts. Molecules (Basel, Switzerland) 21 (4):430. doi: 10.3390/molecules21040430.
  • Jeremic, J. N., V. L. Jakovljevic, V. I. Zivkovic, I. M. Srejovic, J. V. Bradic, S. Bolevich, T. R. Nikolic Turnic, S. L. Mitrovic, N. U. Jovicic, S. C. Tyagi, et al. 2019. The cardioprotective effects of diallyl trisulfide on diabetic rats with ex vivo induced ischemia/reperfusion injury. Molecular and Cellular Biochemistry 460 (1–2):151–64. doi: 10.1007/s11010-019-03577-w.
  • Jezek, P., and K. D. Garlid. 1998. Mammalian mitochondrial uncoupling proteins. The International Journal of Biochemistry & Cell Biology 30 (11):1163–8. doi: 10.1016/s1357-2725(98)00076-4.
  • Jin, S. Y., Y. M. Xu, Y. T. Fu, M. Bai, H. Li, X. C. Li, C. Gao, and X. Bai. 2022. Alleviation of allicin on myocardial injury in diabetic rats through TGF-β1/Smads signaling pathway. Prevention and Treatment of Cardio-Cerebral-Vascular Disease 22:25–30.
  • Jin, Z., F. Z. Liu, W. Y. Guo, P. Q. Jiao, and Y. Q. Chen. 2017. Effect of allicin on apoptosis and Pink1/Parkin signal path of cardiomyocyte in db/db mice. Chinese Journal of Clinical Pharmacology and Therapeutics 22:601–5.
  • Ju, D. Y., Y. G. Choe, Y. K. Cho, D. S. Shin, S. H. Yoo, S. H. Yim, J. Y. Lee, J. H. Park, H. J. Kim, D. I. Park, et al. 2013. The influence of waist circumference on insulin resistance and nonalcoholic fatty liver disease in apparently healthy Korean adults. Clinical and Molecular Hepatology 19 (2):140–7. doi: 10.3350/cmh.2013.19.2.140.
  • Jung, Y. M., S. H. Lee, D. S. Lee, M. J. You, I. K. Chung, W. H. Cheon, Y. S. Kwon, Y. J. Lee, and S. K. Ku. 2011. Fermented garlic protects diabetic, obese mice when fed a high-fat diet by antioxidant effects. Nutrition Research (New York, N.Y.) 31 (5):387–96. doi: 10.1016/j.nutres.2011.04.005.
  • Kadan, S., B. Saad, Y. Sasson, and H. Zaid. 2013. In vitro evaluations of cytotoxicity of eight antidiabetic medicinal plants and their effect on GLUT4 translocation. Evidence-Based Complementary and Alternative Medicine: eCAM 2013:549345. doi: 10.1155/2013/549345.
  • Kaisanlahti, A., and T. Glumoff. 2019. Browning of white fat: Agents and implications for beige adipose tissue to type 2 diabetes. Journal of Physiology and Biochemistry 75 (1):1–10. doi: 10.1007/s13105-018-0658-5.
  • Kalaany, N. Y., K. C. Gauthier, A. M. Zavacki, P. P. Mammen, T. Kitazume, J. A. Peterson, J. D. Horton, D. J. Garry, A. C. Bianco, and D. J. Mangelsdorf. 2005. LXRs regulate the balance between fat storage and oxidation. Cell Metabolism 1 (4):231–44. doi: 10.1016/j.cmet.2005.03.001.
  • Kalhotra, P., V. C. Chittepu, G. Osorio-Revilla, and T. Gallardo-Velazquez. 2020. Phytochemicals in garlic extract inhibit therapeutic enzyme dpp-4 and induce skeletal muscle cell proliferation: A possible mechanism of action to benefit the treatment of diabetes mellitus. Biomolecules 10 (2):305. doi: 10.3390/biom10020305.
  • Kamboj, S. S., K. Chopra, and R. Sandhir. 2009. Hyperglycemia-induced alterations in synaptosomal membrane fluidity and activity of membrane bound enzymes: Beneficial effect of N-acetylcysteine supplementation. Neuroscience 162 (2):349–58. doi: 10.1016/j.neuroscience.2009.05.002.
  • Kang, O. J. 2016. Physicochemical characteristics of black garlic after different thermal processing steps. Preventive Nutrition and Food Science 21 (4):348–54. doi: 10.3746/pnf.2016.21.4.348.
  • Karam, B. S., A. Chavez-Moreno, W. Koh, J. G. Akar, and F. G. Akar. 2017. Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes. Cardiovascular Diabetology 16 (1):120. doi: 10.1186/s12933-017-0604-9.
  • Kashinath, R. T., and P. K. Joseph. 2009. A study on garlic toxicity. Journal of Advanced Research in Biological Sciences 2:39–45.
  • Kaur, G., R. Padiya, R. Adela, U. K. Putcha, G. S. Reddy, B. R. Reddy, K. P. Kumar, S. Chakravarty, and S. K. Banerjee. 2016. Garlic and resveratrol attenuate diabetic complications, loss of β-cells, pancreatic and hepatic oxidative stress in streptozotocin-induced diabetic rats. Frontiers in Pharmacology 7:360.
  • Kesavanarayanan, K. S., S. Sathiya, V. Ranju, A. G. Sunil, R. Ilavarasan, C. Saravana Babu, S. Kavimani, and D. Prathiba. 2012. In vitro cytotoxic, antioxidative and alpha-glucosidase inhibitory potential of a herbal mixture comprised of Allium sativum and Lagerstroemia speciosa. European Review for Medical and Pharmacological Sciences 16 (Suppl 3):58–68.
  • Khare, P., N. Mahajan, D. P. Singh, V. Kumar, V. Kumar, P. Mangal, R. K. Boparai, A. Gesing, S. K. Bhadada, S. S. Sharma, et al. 2021. Allicin, a dietary trpa1 agonist, prevents high fat diet-induced dysregulation of gut hormones and associated complications. Food & Function 12 (22):11526–36. doi: 10.1039/d1fo01792f.
  • Kheiripour, N., J. Karimi, I. Khodadadi, H. Tavilani, M. Taghi Goodarzi, and M. Hashemnia. 2019. Hepatoprotective effects of silymarin on liver injury via irisin upregulation and oxidative stress reduction in rats with type 2 diabetes. Iranian Journal of Medical Sciences 44 (2):108–17.
  • Kheirmandparizi, M., P. Keshavarz, P. Nowrouzi-Sohrabi, M. Hosseini-Bensenjan, S. Rezaei, S. M. A. Kashani, N. Zeidi, R. Tabrizi, and A. Alkamel. 2021. Effects of garlic extract on lipid profile in patients with coronary artery disease: A systematic review and meta-analysis of randomised clinical trials. International Journal of Clinical Practice 75 (12):e14974. doi: 10.1111/ijcp.14974.
  • Khursheed, R., S. K. Singh, S. Wadhwa, B. Kapoor, M. Gulati, R. Kumar, A. K. Ramanunny, A. Awasthi, and K. Dua. 2019. Treatment strategies against diabetes: Success so far and challenges ahead. European Journal of Pharmacology 862:172625. doi: 10.1016/j.ejphar.2019.172625.
  • Kim, J. H., S. H. Yu, Y. J. Cho, J. H. Pan, H. T. Cho, J. H. Kim, H. Bong, Y. Lee, M. H. Chang, Y. J. Jeong, et al. 2017. Preparation of S-Allylcysteine-enriched black garlic juice and its antidiabetic effects in streptozotocin-induced insulin-deficient mice. Journal of Agricultural and Food Chemistry 65 (2):358–63. doi: 10.1021/acs.jafc.6b04948.
  • Kim, J. S. 2020. Antioxidant activity of various soluble melanoidins isolated from black garlic after different thermal processing steps. Preventive Nutrition and Food Science 25 (3):301–9. doi: 10.3746/pnf.2020.25.3.301.
  • Kim, M. H., D. van Noort, J. H. Sung, and S. Park. 2021. Organ-on-a-chip for studying gut-brain interaction mediated by extracellular vesicles in the gut microenvironment. International Journal of Molecular Sciences 22 (24):13513. doi: 10.3390/ijms222413513.
  • Kita, S., N. Maeda, and I. Shimomura. 2019. Interorgan communication by exosomes, adipose tissue, and adiponectin in metabolic syndrome. The Journal of Clinical Investigation 129 (10):4041–9. doi: 10.1172/JCI129193.
  • Kitada, M., Y. Ogura, I. Monno, and D. Koya. 2019. Sirtuins and type 2 diabetes: Role in inflammation, oxidative stress, and mitochondrial function. Frontiers in Endocrinology 10:187. doi: 10.3389/fendo.2019.00187.
  • Knapp, M., X. Tu, and R. Wu. 2019. Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy. Acta Pharmacologica Sinica 40 (1):1–8. doi: 10.1038/s41401-018-0042-6.
  • Kodera, Y., M. Kurita, M. Nakamoto, and T. Matsutomo. 2020. Chemistry of aged garlic: Diversity of constituents in aged garlic extract and their production mechanisms via the combination of chemical and enzymatic reactions. Experimental and Therapeutic Medicine 19:1574–84.
  • Komada, T., and D. A. Muruve. 2019. The role of inflammasomes in kidney disease. Nature Reviews. Nephrology 15 (8):501–20. doi: 10.1038/s41581-019-0158-z.
  • Kumar, P., R. K. Kale, and N. Z. Baquer. 2012. Antihyperglycemic and protective effects of Trigonella foenum graecum seed powder on biochemical alterations in alloxan diabetic rats. European Review for Medical and Pharmacological Sciences 16 (Suppl 3):18–27.
  • Kumar, R., S. Chhatwal, S. Arora, S. Sharma, J. Singh, N. Singh, V. Bhandari, and A. Khurana. 2013. Antihyperglycemic, antihyperlipidemic, anti-inflammatory and adenosine deaminase-lowering effects of garlic in patients with type 2 diabetes mellitus with obesity. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 6:49–56. doi: 10.2147/DMSO.S38888.
  • Kuo, W. W., W. J. Wang, C. Y. Tsai, C. L. Way, H. H. Hsu, and L. M. Chen. 2013. Diallyl trisufide (DATS) suppresses high glucose-induced cardiomyocyte apoptosis by inhibiting JNK/NFκB signaling via attenuating ROS generation. International Journal of Cardiology 168 (1):270–80. doi: 10.1016/j.ijcard.2012.09.080.
  • La Sala, L., F. Prattichizzo, and A. Ceriello. 2019. The link between diabetes and atherosclerosis. European Journal of Preventive Cardiology 26 (2_suppl):15–24. doi: 10.1177/2047487319878373.
  • Lau, -K., -H. Chan, -K. Wong, -C. Teo, -H. Yiu, S. Liu, -W. Li, -O. Shu, -L. Ho, K. H. Chan, et al. 2013. Garlic intake is an independent predictor of endothelial function in patients with ischemic stroke. The Journal of Nutrition, Health & Aging 17 (7):600–4. doi: 10.1007/s12603-013-0043-6.
  • Lawrence, T. 2009. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harbor Perspectives in Biology 1 (6):a001651. [Database] doi: 10.1101/cshperspect.a001651.
  • Lebovitz, H. E. 2001. Insulin resistance: Definition and consequences. Experimental and Clinical Endocrinology & Diabetes 109 (Suppl 2):S135–S48.
  • Lee, C. G., D. K. Rhee, B. O. Kim, S. H. Um, and S. Pyo. 2019. Allicin induces beige-like adipocytes via KLF15 signal cascade. The Journal of Nutritional Biochemistry 64:13–24. doi: 10.1016/j.jnutbio.2018.09.014.
  • Li, C. L., X. H. Liu, Y. Qiao, L. N. Ning, W. J. Li, Y. S. Sun, D. S. Liu, W. Gao, and C. M. Ma. 2020. Allicin alleviates inflammation of diabetic macroangiopathy via the Nrf2 and NF-kB pathway. European Journal of Pharmacology 876:173052. doi: 10.1016/j.ejphar.2020.173052.
  • Li, Q. C., S. Y. Jin, and Y. M. Xu. 2021. Allicin inhibiting liver fibrosis in type 2 diabetic rats through TGF-β1/Smads pathway. China Pharmacist 24:1781–6.
  • Liang, H., and W. F. Ward. 2006. PGC-1alpha: A key regulator of energy metabolism. Advances in Physiology Education 30 (4):145–51. doi: 10.1152/advan.00052.2006.
  • Lim, J. Z., N. S. Ng, and C. Thomas. 2017. Prevention and treatment of diabetic foot ulcers. Journal of the Royal Society of Medicine 110 (3):104–9. doi: 10.1177/0141076816688346.
  • Lim, S., J. Honek, Y. Xue, T. Seki, Z. Cao, P. Andersson, X. Yang, K. Hosaka, and Y. Cao. 2012. Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice. Nature Protocols 7 (3):606–15. doi: 10.1038/nprot.2012.013.
  • Lin, K. H., Y. M. Wei, C. H. Liu, J. S. Liu, I. C. Huang, V. P. Viswanadha, C. Y. Huang, and W. W. Kuo. 2021. Diallyl trisulfide suppresses high-glucose-induced cardiomyocyte apoptosis by targeting reactive oxygen species-mediated hypoxia-inducible factor-1α/insulin-like growth factor binding protein 3 activation. Journal of Agricultural and Food Chemistry. 69 (39):11696–11708. doi: 10.1021/acs.jafc.1c02384.
  • Lin, Y. L., and S. F. Yang. 2011. Effect of allicin on apoptosis and MAPK of heart cell in diabetic rats. Journal of Liaoning University of TCM 13:56–8.
  • Lin, Y. L., X. B. Ye, and S. F. Yang. 2010. Effect of garlic oil on morphology of heart tissue and apoptosis of heart cell in diabetic rats. Journal of the Jiangxi University of Traditional Chinese Medicine 22:64–6.
  • Lin, Y. L., X. B. Ye, and S. F. Yang. 2011. Garlic refined oil influence on rats cardiac muscle cell and PKCδ expression. Journal of Zhejiang Chinese Medical University 35:381–3.
  • Liu, C. T., T. W. Hsu, K. M. Chen, Y. P. Tan, C. K. Lii, and L. Y. Sheen. 2012. The antidiabetic effect of garlic oil is associated with ameliorated oxidative stress but not ameliorated level of pro-inflammatory cytokines in skeletal muscle of streptozotocin-induced diabetic rats. Journal of Traditional and Complementary Medicine 2 (2):135–44. doi: 10.1016/S2225-4110(16)30087-6.
  • Liu, C. T., L. Y. Sheen, and C. K. Lii. 2007. Does garlic have a role as an antidiabetic agent? Molecular Nutrition & Food Research 51 (11):1353–64. doi: 10.1002/mnfr.200700082.
  • Liu, L. L., L. Yan, Y. H. Chen, G. H. Zeng, Y. Zhou, H. P. Chen, W. J. Peng, M. He, and Q. R. Huang. 2014. A role for diallyl trisulfide in mitochondrial antioxidative stress contributes to its protective effects against vascular endothelial impairment. European Journal of Pharmacology 725:23–31. doi: 10.1016/j.ejphar.2014.01.010.
  • Liu, Y., H. Qi, Y. Wang, M. Wu, Y. Cao, W. Huang, L. Li, Z. Ji, and H. Sun. 2012. Allicin protects against myocardial apoptosis and fibrosis in streptozotocin-induced diabetic rats. Phytomedicine 19 (8–9):693–8. doi: 10.1016/j.phymed.2012.04.007.
  • Longo, M., F. Zatterale, J. Naderi, L. Parrillo, P. Formisano, G. A. Raciti, F. Beguinot, and C. Miele. 2019. Adipose tissue dysfunction as determinant of obesity-associated metabolic complications. International Journal of Molecular Sciences 20 (9):2358. doi: 10.3390/ijms20092358.
  • Lontchi-Yimagou, E., E. Sobngwi, T. E. Matsha, and A. P. Kengne. 2013. Diabetes mellitus and inflammation. Current Diabetes Reports 13 (3):435–44. doi: 10.1007/s11892-013-0375-y.
  • Lopes, L., O. Setia, A. Aurshina, S. Liu, H. Hu, T. Isaji, H. Liu, T. Wang, S. Ono, X. Guo, et al. 2018. Stem cell therapy for diabetic foot ulcers: A review of preclinical and clinical research. Stem Cell Research & Therapy 9 (1):188. doi: 10.1186/s13287-018-0938-6.
  • Lotfi, F., N. Ziamajidi, R. Abbasalipourkabir, M. T. Goodarzi, and S. S. Asl. 2021. Impacts of garlic extract on testicular oxidative stress and sperm characteristics in type 1 and 2 diabetic rats: An experimental study. International Journal of Reproductive Biomedicine 19 (10):929–42. doi: 10.18502/ijrm.v19i10.9825.
  • Lu, X. D., G. j. Zong, J. Y. Zhou, and L. J. Zhang. 2019. Effect of allicin on improving cardiac function and fibrosis in rats with diabetic cardiomyopathy and its effect on NF-κB signaling pathway. China Pharmaceuticals 28:22–5.
  • Luan, H. Y., Y. J. Han, Z. Guan, Z. H. Ye, X. S. Zhang, and L. M. Yang. 2017. Regulatory effect of allicin on glut1/PKC pathway in rats with diabetic nephropathy. Chinese Journal of Gerontology 37:2347–9.
  • Luan, H. Y., Y. Z. Han, Z. Guan, X. G. Wang, L. L. Jia, X. Y. Jia, X. Y. Yang, and M. Guo. 2017. Regulatory effect of allicin on renal interstitial fibrosis in diabetic patients. Heilongjiang Medicine and Pharmacy 40:18–9.
  • Luc, K., A. Schramm-Luc, T. J. Guzik, and T. P. Mikolajczyk. 2019. Oxidative stress and inflammatory markers in prediabetes and diabetes. Journal of Physiology and Pharmacology 70 (6):809–824. doi: 10.26402/jpp.2019.6.01.
  • Luther, J. M., and N. J. Brown. 2011. The renin-angiotensin-aldosterone system and glucose homeostasis. Trends in Pharmacological Sciences 32 (12):734–9. doi: 10.1016/j.tips.2011.07.006.
  • Lyons, C. L., and H. M. Roche. 2018. Nutritional modulation of AMPK-impact upon metabolic-inflammation. International Journal of Molecular Sciences 19 (10):3092. doi: 10.3390/ijms19103092.
  • Ma, Q., Y. Li, P. Li, M. Wang, J. Wang, Z. Tang, T. Wang, L. Luo, C. Wang, T. Wang, et al. 2019. Research progress in the relationship between type 2 diabetes mellitus and intestinal flora. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 117:109138. doi: 10.1016/j.biopha.2019.109138.
  • Ma, X., P. Lee, D. J. Chisholm, and D. E. James. 2015. Control of adipocyte differentiation in different fat depots; implications for pathophysiology or therapy. Front Endocrinol (Lausanne) 6:1.
  • Madkor, H. R., S. W. Mansour, and G. Ramadan. 2011. Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocin-nicotinamide diabetic rats. The British Journal of Nutrition 105 (8):1210–7. doi: 10.1017/S0007114510004927.
  • Maeda, T., S. Miki, N. Morihara, and Y. Kagawa. 2019. Aged garlic extract ameliorates fatty liver and insulin resistance and improves the gut microbiota profile in a mouse model of insulin resistance. Experimental and Therapeutic Medicine 18 (1):857–66. doi: 10.3892/etm.2019.7636.
  • Mahdavi, A., M. Bagherniya, M. S. Mirenayat, S. L. Atkin, and A. Sahebkar. 2021. Medicinal plants and phytochemicals regulating insulin resistance and glucose homeostasis in type 2 diabetic patients: A clinical review. Advances in Experimental Medicine and Biology 1308:161–83. doi: 10.1007/978-3-030-64872-5_13.
  • Majewski, M. 2014. Allium sativum: Facts and myths regarding human health. Roczniki Panstwowego Zakladu Higieny 65 (1):1–8.
  • Mansour, M. H., K. Al-Qattan, M. Thomson, and M. Ali. 2013. Garlic (Allium sativum) down-regulates the expression of angiotensin II AT(1) receptor in adrenal and renal tissues of streptozotocin-induced diabetic rats. Inflammopharmacology 21 (2):147–59. doi: 10.1007/s10787-012-0139-3.
  • Martínez-Pizarro, S. 2020. Influence of garlic on hypertension. Hipertension y Riesgo Vascular 37 (1):47–9. doi: 10.1016/j.hipert.2019.11.002.
  • Martins, J. O., M. Ferracini, D. B. Anger, D. O. Martins, L. F. Ribeiro, Jr., P. Sannomiya, and S. Jancar. 2010. Signaling pathways and mediators in LPS-induced lung inflammation in diabetic rats: Role of insulin. Shock (Augusta, GA) 33 (1):76–82. doi: 10.1097/SHK.0b013e3181a85ec4.
  • Marwick, T. H., R. Ritchie, J. E. Shaw, and D. Kaye. 2018. Implications of underlying mechanisms for the recognition and management of diabetic cardiomyopathy. Journal of the American College of Cardiology 71 (3):339–51. doi: 10.1016/j.jacc.2017.11.019.
  • Mary-Elizabeth, P., and C. Silvia. 2010. The role of mitochondria in the pathogenesis of type 2 diabetes. Endocrine Reviews 31:364–95.
  • Masjedi, F., A. Gol, and S. Dabiri. 2013. Preventive effect of garlic (Allium sativum L.) on serum biochemical factors and histopathology of pancreas and liver in streptozotocin- induced diabetic rats. Iranian Journal of Pharmaceutical Research 12:325–38.
  • Mateen, A. A., P. U. Rani, M. U. Naidu, and E. Chandrashekar. 2011. Pharmacodynamic interaction study of Allium sativum (garlic) with cilostazol in patients with type II diabetes mellitus. Indian Journal of Pharmacology 43 (3):270–4. doi: 10.4103/0253-7613.81514.
  • Matsumoto, S., T. Yoshida, H. Murata, S. Harada, N. Fujita, S. Nakamura, Y. Yamamoto, T. Watanabe, H. Yonekura, H. Yamamoto, et al. 2008. Solution structure of the variable-type domain of the receptor for advanced glycation end products: New insight into AGE-RAGE interaction. Biochemistry 47 (47):12299–311. doi: 10.1021/bi800910v.
  • Meikle, P. J., and S. A. Summers. 2017. Sphingolipids and phospholipids in insulin resistance and related metabolic disorders. Nature Reviews. Endocrinology 13 (2):79–91. doi: 10.1038/nrendo.2016.169.
  • Melino, S., S. Leo, and V. Toska Papajani. 2019. Natural hydrogen sulfide donors from allium sp. as a nutraceutical approach in type 2 diabetes prevention and therapy. Nutrients 11 (7):1581. doi: 10.3390/nu11071581.
  • Méndez, J. D. 2003. Advanced glycosylation end products and chronic complications of diabetes mellitus. Gaceta Medica de Mexico 139 (1):49–55.
  • Miki, S., K. I. Inokuma, M. Takashima, M. Nishida, Y. Sasaki, M. Ushijima, J. I. Suzuki, and N. Morihara. 2017. Aged garlic extract suppresses the increase of plasma glycated albumin level and enhances the AMP-activated protein kinase in adipose tissue in TSOD mice. Molecular Nutrition & Food Research 61 (5):1600797. doi: 10.1002/mnfr.201600797
  • Mizuno, C. S., A. G. Chittiboyina, T. W. Kurtz, H. A. Pershadsingh, and M. A. Avery. 2008. Type 2 diabetes and oral antihyperglycemic drugs. Current Medicinal Chemistry 15 (1):61–74. doi: 10.2174/092986708783330656.
  • Mohammadi, A., and E. A. Oshaghi. 2014. Effect of garlic on lipid profile and expression of LXR alpha in intestine and liver of hypercholesterolemic mice. Journal of Diabetes and Metabolic Disorders 13 (1):20. doi: 10.1186/2251-6581-13-20.
  • Molinaro, A., A. Wahlström, and H. U. Marschall. 2018. Role of bile acids in metabolic control. Trends in Endocrinology and Metabolism: TEM 29 (1):31–41. doi: 10.1016/j.tem.2017.11.002.
  • Mong, M., and C. M. C. Yin. 2012. Nuclear factor κB-dependent anti-inflammatory effects of s-allyl cysteine and s-propyl cysteine in kidney of diabetic mice. Journal of Agricultural and Food Chemistry 60 (12):3158–65. doi: 10.1021/jf3002685.
  • Mooradian, A. D., G. Grabau, and B. Bastani. 1994. Adenosine triphosphatases of rat cerebral microvessels. Effect of age and diabetes mellitus. Life Sciences 55 (16):1261–5. doi: 10.1016/0024-3205(94)90064-7.
  • Moradabadi, L., S. Montasser Kouhsari, and M. Fehresti Sani. 2013. Hypoglycemic effects of three medicinal plants in experimental diabetes: Inhibition of rat intestinal α-glucosidase and enhanced pancreatic insulin and cardiac glut-4 mRNAs expression. Iranian Journal of Pharmaceutical Research: IJPR 12 (3):387–97.
  • Morcos, N. C. 1997. Modulation of lipid profile by fish oil and garlic combination. Journal of the National Medical Association 89 (10):673–8.
  • Muriach, M., M. Flores-Bellver, F. J. Romero, and J. M. Barcia. 2014. Diabetes and the brain: Oxidative stress, inflammation, and autophagy. Oxidative Medicine and Cellular Longevity 2014:102158. [Database] doi: 10.1155/2014/102158.
  • Myers, S. P., and A. J. Smith. 1997. Cardioprotection and garlic. Lancet (London, England) 349 (9045):131–2. doi: 10.1016/S0140-6736(05)60913-0.
  • Nabatame, Y., T. Hosooka, C. Aoki, Y. Hosokawa, M. Imamori, Y. Tamori, Y. Okamatsu-Ogura, T. Yoneshiro, S. Kajimura, M. Saito, et al. 2021. Kruppel-like factor 15 regulates fuel switching between glucose and fatty acids in brown adipocytes. Journal of Diabetes Investigation 12 (7):1144–51. doi: 10.1111/jdi.13511.
  • Naderi, R., G. Mohaddes, M. Mohammadi, A. Alihemmati, R. Badalzadeh, R. Ghaznavi, R. Ghyasi, and S. Mohammadi. 2015. Preventive effects of garlic (Allium sativum) on oxidative stress and histopathology of cardiac tissue in streptozotocin-induced diabetic rats. Acta Physiologica Hungarica 102 (4):380–90. doi: 10.1556/036.102.2015.4.5.
  • Naderi, R., G. Mohaddes, M. Mohammadi, A. Alihemmati, A. Khamaneh, R. Ghyasi, and R. Ghaznavi. 2019. The effect of garlic and voluntary exercise on cardiac angiogenesis in diabetes: The role of MiR-126 and MiR-210. Arquivos Brasileiros de Cardiologia 112 (2):154–62. doi: 10.5935/abc.20190002.
  • Naidu, P. B., V. V. Sathibabu Uddandrao, R. R. Naik, S. Pothani, P. K. Munipally, B. Meriga, M. S. Begum, C. Varatharaju, R. Pandiyan, and G. Saravanan. 2016. Effects of S-Allylcysteine on biomarkers of the polyol pathway in rats with type 2 diabetes. Canadian Journal of Diabetes 40 (5):442–8. doi: 10.1016/j.jcjd.2016.03.006.
  • Nakamura, K., J. J. Fuster, and K. Walsh. 2014. Adipokines: A link between obesity and cardiovascular disease. Journal of Cardiology 63 (4):250–9. doi: 10.1016/j.jjcc.2013.11.006.
  • Nasim, S. A., B. Dhir, R. Kapoor, S. Fatima, Mahmooduzzafar, and A. Mujib. 2011. Alliin obtained from leaf extract of garlic grown under in situ conditions possess higher therapeutic potency as analyzed in alloxan-induced diabetic rats. Pharmaceutical Biology 49 (4):416–21. doi: 10.3109/13880209.2010.521163.
  • Nasiri, A., N. Ziamajidi, R. Abbasalipourkabir, M. T. Goodarzi, M. Saidijam, H. Behrouj, and S. Solemani Asl. 2017. Beneficial effect of aqueous garlic extract on inflammation and oxidative stress status in the kidneys of type 1 diabetic rats. Indian Journal of Clinical Biochemistry: IJCB 32 (3):329–36. doi: 10.1007/s12291-016-0621-6.
  • Navar, L. G., K. D. Mitchell, L. M. Harrison-Bernard, H. Kobori, and A. Nishiyama. 2001. Review: Intrarenal angiotensin II levels in normal and hypertensive states. Journal of the Renin-Angiotensin-Aldosterone System 2 (1_suppl):S176–S184. doi: 10.1177/14703203010020013001.
  • Nicastro, H. L., S. A. Ross, and J. A. Milner. 2015. Garlic and onions: Their cancer prevention properties. Cancer Prevention Research (Philadelphia, PA) 8 (3):181–9. doi: 10.1158/1940-6207.CAPR-14-0172.
  • Nie, X. M., Y. X. Zhao, D. M. Shi, Y. Y. Liu, Z. M. Zhou, L. X. Su, and Y. J. Zhou. 2013. Effects of allitridi capsules on endothelial function and clinical prognosis after percutaneous coronary intervention in coronary artery disease patients with diabetes mellitus. Zhonghua yi Xue za Zhi 93 (26):2052–5.
  • Nirala, B. K., and N. K. Gohil. 2015. Effect of garlic component s-allyl cysteine sulfoxide on glycated human serum albumin induced activation of endothelial cells: An in vitro study. European Review for Medical and Pharmacological Sciences 19:2125–31.
  • Nishiyama, N., T. Moriguchi, and H. Saito. 1997. Beneficial effects of aged garlic extract on learning and memory impairment in the senescence-accelerated mouse. Experimental Gerontology 32 (1–2):149–60. doi: 10.1016/s0531-5565(96)00062-9.
  • Nogueiras, R., H. Wilson, F. Rohner-Jeanrenaud, and M. H. Tschöp. 2008. Central nervous system regulation of adipocyte metabolism. Regulatory Peptides 149 (1–3):26–31. doi: 10.1016/j.regpep.2007.09.034.
  • Noor, S., R. U. Khan, and J. Ahmad. 2017. Understanding diabetic foot infection and its management. Diabetes & Metabolic Syndrome 11 (2):149–56. doi: 10.1016/j.dsx.2016.06.023.
  • Oboh, G., A. O. Ademiluyi, O. M. Agunloye, A. O. Ademosun, and B. G. Ogunsakin. 2019. Inhibitory effect of garlic, purple onion, and white onion on key enzymes linked with type 2 diabetes and hypertension. Journal of Dietary Supplements 16 (1):105–18. doi: 10.1080/19390211.2018.1438553.
  • Ogura, Y., M. Kitada, and D. Koya. 2021. Sirtuins and renal oxidative stress. Antioxidants (Basel) 10 (8):1198. doi: 10.3390/antiox10081198.
  • Omar, S. A., A. J. Webb, J. O. Lundberg, and E. Weitzberg. 2016. Therapeutic effects of inorganic nitrate and nitrite in cardiovascular and metabolic diseases. Journal of Internal Medicine 279 (4):315–36. doi: 10.1111/joim.12441.
  • Oppenländer, L., S. Palit, K. Stemmer, T. Greisle, M. Sterr, C. Salinno, A. Bastidas-Ponce, A. Feuchtinger, A. Böttcher, F. J. Theis, et al. 2021. Vertical sleeve gastrectomy triggers fast β-cell recovery upon overt diabetes. Molecular Metabolism 54:101330. doi: 10.1016/j.molmet.2021.101330.
  • Osman, M., A. Adnan, N. Salmah Bakar, and F. Alashkham. 2012. Allicin has significant effect on autoimmune anti-islet cell antibodies in type 1 diabetic rats. Polish Journal of Pathology 63 (4):248–54. doi: 10.5114/pjp.2012.32772.
  • Padiya, R., and S. K. Banerjee. 2013. Garlic as an anti-diabetic agent: Recent progress and patent reviews. Recent Patents on Food, Nutrition & Agriculture 5 (2):105–27. doi: 10.2174/18761429113059990002.
  • Padiya, R., D. Chowdhury, R. Borkar, R. Srinivas, M. Pal Bhadra, and S. K. Banerjee. 2014. Garlic attenuates cardiac oxidative stress via activation of PI3K/AKT/Nrf2-Keap1 pathway in fructose-fed diabetic rat. PLoS One 9 (5):e94228. doi: 10.1371/journal.pone.0094228.
  • Padiya, R., T. N. Khatua, P. K. Bagul, M. Kuncha, and S. K. Banerjee. 2011. Garlic improves insulin sensitivity and associated metabolic syndromes in fructose fed rats. Nutrition & Metabolism 8:53. doi: 10.1186/1743-7075-8-53.
  • Paolillo, S., F. Marsico, M. Prastaro, F. Renga, L. Esposito, F. De Martino, P. Di Napoli, I. Esposito, A. Ambrosio, M. Ianniruberto, et al. 2019. Diabetic cardiomyopathy: Definition, diagnosis, and therapeutic implications. Heart Failure Clinics 15 (3):341–7. doi: 10.1016/j.hfc.2019.02.003.
  • Papageorgiou, C., J. P. Corbet, F. Menezes-Brandao, M. Pecegueiro, and C. Benezra. 1983. Allergic contact dermatitis to garlic (Allium sativum L.). Identification of the allergens: The role of mono-, di-, and trisulfides present in garlic. A comparative study in man and animal (guinea-pig). Archives of Dermatological Research 275 (4):229–34. doi: 10.1007/BF00416666.
  • Patterson, E., P. M. Ryan, J. F. Cryan, T. G. Dinan, R. P. Ross, G. F. Fitzgerald, and C. Stanton. 2016. Gut microbiota, obesity and diabetes. Postgraduate Medical Journal 92 (1087):286–300. doi: 10.1136/postgradmedj-2015-133285.
  • Peng, J., B. Liu, Q. L. Ma, and X. J. Luo. 2015. Dysfunctional endothelial progenitor cells in cardiovascular diseases: Role of NADPH oxidase. Journal of Cardiovascular Pharmacology 65 (1):80–7. doi: 10.1097/FJC.0000000000000166.
  • Peng, W., R. Chen, Z. Jiang, X. Xu, J. Wang, J. Li, and C. Liu. 2014. Correlation between cognitive function and hippocampal atrophy and cerebral white matter lesions in patients with obstructive sleep apnea hypopnea syndrome. Zhonghua yi Xue za Zhi 94 (10):724–8.
  • Peng, Y., and K. Hu. 2018. Effect of garlic on rats with chronic intermittent hypoxia combined with diabetes mellitus. Molecular Medicine Reports 17 (4):6174–84. doi: 10.3892/mmr.2018.8568.
  • Pierini, D., and N. S. Bryan. 2015. Nitric oxide availability as a marker of oxidative stress. Methods in Molecular Biology (Clifton, NJ) 1208:63–71. doi: 10.1007/978-1-4939-1441-8_5.
  • Piragine, E., and V. Calderone. 2021. Pharmacological modulation of the hydrogen sulfide (H(2) S) system by dietary H(2) S-donors: A novel promising strategy in the prevention and treatment of type 2 diabetes mellitus. Phytotherapy Research: PTR 35 (4):1817–46. doi: 10.1002/ptr.6923.
  • Poonam, T., G. P. Prakash, and L. V. Kumar. 2013. Influence of Allium sativum extract on the hypoglycemic activity of glibenclamide: An approach to possible herb-drug interaction. Drug Metabolism and Drug Interactions 28 (4):225–30. doi: 10.1515/dmdi-2013-0031.
  • Portillo, M. P., E. Simón, M. A. García-Calonge, and A. S. Del Barrio. 1999. Effect of high-fat diet on lypolisis in isolated adipocytes from visceral and subcutaneous WAT. European Journal of Nutrition 38 (4):177–82. doi: 10.1007/s003940050059.
  • Poulose, N., and R. Raju. 2014. Aging and injury: Alterations in cellular energetics and organ function. Aging and Disease 5 (2):101–8. doi: 10.14336/AD.2014.0500101.
  • Queiroz, L. A. D., J. B. Assis, J. P. T. Guimarães, E. S. A. Sousa, A. C. Milhomem, K. K. S. Sunahara, A. Sá-Nunes, and J. O. Martins. 2021. Endangered lymphocytes: The effects of alloxan and streptozotocin on immune cells in type 1 induced diabetes. Mediators of Inflammation 2021:9940009. doi: 10.1155/2021/9940009.
  • Quintero-Fabián, S., D. Ortuño-Sahagún, M. Vázquez-Carrera, and R. I. López-Roa. 2013. Alliin, a garlic (Allium sativum) compound, prevents LPS-induced inflammation in 3T3-L1 adipocytes. Mediators of Inflammation 2013:381815. doi: 10.1155/2013/381815.
  • Rae, C., D. J. Bartlett, Q. Yang, D. Walton, A. Denotti, T. Sachinwalla, and R. R. Grunstein. 2009. Dynamic changes in brain bioenergetics during obstructive sleep apnea. Journal of Cerebral Blood Flow and Metabolism 29 (8):1421–8. doi: 10.1038/jcbfm.2009.57.
  • Rahmani, G., F. Farajdokht, G. Mohaddes, S. Babri, V. Ebrahimi, and H. Ebrahimi. 2020. Garlic (Allium sativum) improves anxiety- and depressive-related behaviors and brain oxidative stress in diabetic rats. Archives of Physiology and Biochemistry 126 (2):95–100. doi: 10.1080/13813455.2018.1494746.
  • Ramasamy, R., S. F. Yan, and A. M. Schmidt. 2012. Advanced glycation endproducts: From precursors to RAGE: Round and round we go. Amino Acids 42 (4):1151–61. doi: 10.1007/s00726-010-0773-2.
  • Rana, S. V., R. Pal, K. Vaiphei, S. K. Sharma, and R. P. Ola. 2011. Garlic in health and disease. Nutrition Research Reviews 24 (1):60–71. doi: 10.1017/S0954422410000338.
  • Reinhart, K. M., R. Talati, C. M. White, and C. I. Coleman. 2009. The impact of garlic on lipid parameters: A systematic review and meta-analysis. Nutrition Research Reviews 22 (1):39–48. doi: 10.1017/S0954422409350003.
  • Repa, J. J., G. Liang, J. Ou, Y. Bashmakov, J. M. Lobaccaro, I. Shimomura, B. Shan, M. S. Brown, J. L. Goldstein, and D. J. Mangelsdorf. 2000. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes & Development 14 (22):2819–30. doi: 10.1101/gad.844900.
  • Ribeiro, M., L. Alvarenga, L. Cardozo, T. R. Chermut, J. Sequeira, L. de Souza Gouveia Moreira, K. T. R. Teixeira, P. G. Shiels, P. Stenvinkel, and D. Mafra. 2021. From the distinctive smell to therapeutic effects: Garlic for cardiovascular, hepatic, gut, diabetes and chronic kidney disease. Clinical Nutrition (Edinburgh, Scotland) 40 (7):4807–19. doi: 10.1016/j.clnu.2021.03.005.
  • Riddle, M. C., W. T. Cefalu, P. H. Evans, H. C. Gerstein, M. A. Nauck, W. K. Oh, A. E. Rothberg, C. W. Le Roux, F. Rubino, P. Schauer, et al. 2021. Consensus report: Definition and interpretation of remission in type 2 diabetes. Diabetologia 64 (11):2359–66. doi: 10.1007/s00125-021-05542-z.
  • Ried, K. 2016. Garlic lowers blood pressure in hypertensive individuals, regulates serum cholesterol, and stimulates immunity: An updated meta-analysis and review. The Journal of Nutrition 146 (2):389s–96S. doi: 10.3945/jn.114.202192.
  • Ried, K., C. Toben, and P. Fakler. 2013. Effect of garlic on serum lipids: An updated meta-analysis. Nutrition Reviews 71 (5):282–99. doi: 10.1111/nure.12012.
  • Riedel, U., E. Schüßler, D. Härtel, A. Keiler, S. Nestoris, and H. Stege. 2020. Wound treatment in diabetes patients and diabetic foot ulcers. Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete 71 (11):835–42. doi: 10.1007/s00105-020-04699-9.
  • Ritchie, R. H., and E. D. Abel. 2020. Basic mechanisms of diabetic heart disease. Circulation Research 126 (11):1501–25. doi: 10.1161/CIRCRESAHA.120.315913.
  • Rochette, L., M. Zeller, Y. Cottin, and C. Vergely. 2018. Redox functions of heme oxygenase-1 and biliverdin reductase in diabetes. Trends in Endocrinology and Metabolism: TEM 29 (2):74–85. doi: 10.1016/j.tem.2017.11.005.
  • Ryan, E. A., M. E. Pick, and C. Marceau. 2001. Use of alternative medicines in diabetes mellitus. Diabetic Medicine 18 (3):242–5. doi: 10.1046/j.1464-5491.2001.00450.x.
  • Ryu, J. H., and D. Kang. 2017. Physicochemical properties, biological activity, health benefits, and general limitations of aged black garlic: A review. Molecules 22 (6):919. doi: 10.3390/molecules22060919.
  • Sachs, S., A. Bastidas-Ponce, S. Tritschler, M. Bakhti, A. Böttcher, M. A. Sánchez-Garrido, M. Tarquis-Medina, M. Kleinert, K. Fischer, S. Jall, et al. 2020. Targeted pharmacological therapy restores β-cell function for diabetes remission. Nature Metabolism 2 (2):192–209. doi: 10.1038/s42255-020-0171-3.
  • Saha, A. K., and N. B. Ruderman. 2003. Malonyl-CoA and AMP-activated protein kinase: An expanding partnership. Molecular and Cellular Biochemistry 253 (1–2):65–70. doi: 10.1023/a:1026053302036.
  • Saiki, A., M. Ohira, T. Yamaguchi, D. Nagayama, N. Shimizu, K. Shirai, and I. Tatsuno. 2020. New horizons of arterial stiffness developed using cardio-ankle vascular index (CAVI). Journal of Atherosclerosis and Thrombosis 27 (8):732–48. doi: 10.5551/jat.RV17043.
  • Sainani, G. S., D. B. Desai, N. H. Gorhe, S. M. Natu, D. V. Pise, and P. G. Sainani. 1979. Effect of dietary garlic and onion on serum lipid profile in Jain community. The Indian Journal of Medical Research 69:776–80.
  • Sakurai, H., A. Katoh, T. Kiss, T. Jakusch, and M. Hattori. 2010. Metallo-allixinate complexes with anti-diabetic and anti-metabolic syndrome activities. Metallomics: Integrated Biometal Science 2 (10):670–82. doi: 10.1039/c0mt00025f.
  • Sambu, N. K., R. T. Kashinath, and J. G. Ambekar. 2015. Effect of diallyl disulphide on diabetes induced dyslipidemia in male albino rats. Journal of Clinical and Diagnostic Research: JCDR 9 (4):Bf01–3. doi: 10.7860/JCDR/2015/13374.5860.
  • Saravanan, G., and P. Ponmurugan. 2011. Ameliorative potential of S-allyl cysteine on oxidative stress in STZ induced diabetic rats. Chemico-Biological Interactions 189 (1–2):100–6. doi: 10.1016/j.cbi.2010.10.001.
  • Saravanan, G., and P. Ponmurugan. 2012. Antidiabetic effect of S-allylcysteine: Effect on thyroid hormone and circulatory antioxidant system in experimental diabetic rats. Journal of Diabetes and Its Complications 26 (4):280–5. doi: 10.1016/j.jdiacomp.2012.03.024.
  • Saravanan, G., and P. Ponmurugan. 2013. S-allylcysteine improves streptozotocin-induced alterations of blood glucose, liver cytochrome P450 2E1, plasma antioxidant system, and adipocytes hormones in diabetic rats. International Journal of Endocrinology and Metabolism 11 (4):e10927. doi: 10.5812/ijem.10927.
  • Saravanan, G., P. Ponmurugan, and M. S. Begum. 2013. Effect of S-allylcysteine, a sulphur containing amino acid on iron metabolism in streptozotocin induced diabetic rats. Journal of Trace Elements in Medicine and Biology: Organ of the Society for Minerals and Trace Elements (GMS) 27 (2):143–7. doi: 10.1016/j.jtemb.2012.07.009.
  • Sarkaki, A., S. Valipour Chehardacheric, Y. Farbood, S. M. Mansouri, B. Naghizadeh, and E. Basirian. 2013. Effects of fresh, aged and cooked garlic extracts on short- and long-term memory in diabetic rats. Avicenna J Phytomed 3:45–55.
  • Scarale, M. G., M. Copetti, M. Garofolo, A. Fontana, L. Salvemini, S. De Cosmo, O. Lamacchia, G. Penno, V. Trischitta, and C. Menzaghi. 2020. The synergic association of hs-CRP and serum amyloid P component in predicting all-cause mortality in patients with type 2 diabetes. Diabetes Care 43 (5):1025–32. doi: 10.2337/dc19-2489.
  • Semuyaba, I., A. A. Safiriyu, E. A. Tiyo, and R. F. Niurka. 2017. Memory improvement effect of ethanol garlic (A. sativum) extract in streptozotocin-nicotinamide induced diabetic wistar rats is mediated through increasing of hippocampal sodium-potassium ATPase, glutamine synthetase, and calcium ATPase activities. Evidence-Based Complementary and Alternative Medicine 2017:1–7. doi: 10.1155/2017/3720380.
  • Senthilkumar, G. P., S. Thomas, S. K. P. Sankar, and Z. Bobby. 2013. Study the effect of s-methyl L-cysteine on lipid metabolism in an experimental model of diet induced obesity. Journal of Clinical and Diagnostic Research 7:2449–51.
  • Shabani, E., K. Sayemiri, and M. Mohammadpour. 2019. The effect of garlic on lipid profile and glucose parameters in diabetic patients: A systematic review and meta-analysis. Primary Care Diabetes 13 (1):28–42. doi: 10.1016/j.pcd.2018.07.007.
  • Shaikh, K., A. Kinninger, L. Cherukuri, D. Birudaraju, R. Nakanishi, S. Almeida, E. Jayawardena, C. Shekar, F. Flores, S. Hamal, et al. 2020. Aged garlic extract reduces low attenuation plaque in coronary arteries of patients with diabetes: A randomized, double-blind, placebo-controlled study. Experimental and Therapeutic Medicine 19:1457–61.
  • Shang, A., S. Y. Cao, X. Y. Xu, R. Y. Gan, G. Y. Tang, H. Corke, V. Mavumengwana, and H. B. Li. 2019. Bioactive compounds and biological functions of garlic (Allium sativum L.). Foods 8 (7):246. doi: 10.3390/foods8070246.
  • Shen, J. F., H. P. Zhu, F. Hu, Z. Y. Yan, Y. S. Li, and S. Zhong. 2022. Effect of diallyl trisulfide on pyroptosis in renal tissue of diabetic nephropathy rats. Journal of Guangzhou University of Traditional Chinese Medicine 39:1643–50.
  • Sher, A., M. Fakhar-Ul-Mahmood, S. N. Shah, S. Bukhsh, and G. Murtaza. 2012. Effect of garlic extract on blood glucose level and lipid profile in normal and alloxan diabetic rabbits. Advances in Clinical and Experimental Medicine 21 (6):705–11.
  • Shi, X., X. Zhou, X. Chu, J. Wang, B. Xie, J. Ge, Y. Guo, X. Li, and G. Yang. 2019. Allicin improves metabolism in high-fat diet-induced obese mice by modulating the gut microbiota. Nutrients 11 (12):2909. doi: 10.3390/nu11122909.
  • Shi, Y., and P. M. Vanhoutte. 2017. Macro- and microvascular endothelial dysfunction in diabetes. Journal of Diabetes 9 (5):434–49. doi: 10.1111/1753-0407.12521.
  • Shiju, T. M., N. G. Rajesh, and P. Viswanathan. 2013. Renoprotective effect of aged garlic extract in streptozotocin-induced diabetic rats. Indian Journal of Pharmacology 45 (1):18–23. doi: 10.4103/0253-7613.106429.
  • Shiju, T. M., R. Rajkumar, N. G. Rajesh, and P. Viswanathan. 2013. Aqueous extract of Allium sativum L bulbs offer nephroprotection by attenuating vascular endothelial growth factor and extracellular signal-regulated kinase-1 expression in diabetic rats. Indian Journal of Experimental Biology 51 (2):139–48.
  • Shoelson, S. E., J. Lee, and M. Yuan. 2003. Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance. International Journal of Obesity and Related Metabolic Disorders 27 (Suppl 3):S49–S52.
  • Si, L., R. Lin, Y. Jia, W. Jian, Q. Yu, M. Wang, and S. Yang. 2019. Lactobacillus bulgaricus improves antioxidant capacity of black ­garlic in the prevention of gestational diabetes mellitus: A randomized control trial. Bioscience Reports 39 (8):BSR20182254. doi: 10.1042/BSR20182254.
  • Simó-Servat, O., A. Planas, A. Ciudin, R. Simó, and C. Hernández. 2018. Assessment of advanced glycation end-products as a biomarker of diabetic outcomes. Endocrinologia, Diabetes y Nutricion 65 (9):540–5. doi: 10.1016/j.endinu.2018.06.003.
  • Sivaraman, K., G. P. Senthilkumar, P. Sankar, and Z. Bobby. 2013. Attenuation of oxidative stress, inflammation and insulin resistance by allium sativum in fructose-fed male rats. Journal of Clinical and Diagnostic Research: JCDR 7 (9):1860–2. doi: 10.7860/JCDR/2013/6924.3334.
  • Sobenin, I. A., L. V. Nedosugova, L. V. Filatova, M. I. Balabolkin, T. V. Gorchakova, and A. N. Orekhov. 2008. Metabolic effects of time-released garlic powder tablets in type 2 diabetes mellitus: The results of double-blinded placebo-controlled study. Acta Diabetologica 45 (1):1–6. doi: 10.1007/s00592-007-0011-x.
  • Søberg, S., J. Löfgren, F. E. Philipsen, M. Jensen, A. E. Hansen, E. Ahrens, K. B. Nystrup, R. D. Nielsen, C. Sølling, A. S. Wedell-Neergaard, et al. 2021. Altered brown fat thermoregulation and enhanced cold-induced thermogenesis in young, healthy, winter-swimming men. Cell Reports. Medicine 2 (10):100408. doi: 10.1016/j.xcrm.2021.100408.
  • Soleimani, D., Z. Paknahad, and M. H. Rouhani. 2020. Therapeutic effects of garlic on hepatic steatosis in nonalcoholic fatty liver disease patients: A randomized clinical trial. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 13:2389–97. doi: 10.2147/DMSO.S254555.
  • Stevinson, C., M. H. Pittler, and E. Ernst. 2000. Garlic for treating hypercholesterolemia. A meta-analysis of randomized clinical trials. Annals of Internal Medicine 133 (6):420–9. doi: 10.7326/0003-4819-133-6-200009190-00009.
  • Strippoli, G. F., S. Di Paolo, R. Cincione, A. M. Di Palma, A. Teutonico, G. Grandaliano, F. P. Schena, and L. Gesualdo. 2003. Clinical and therapeutic aspects of diabetic nephropathy. Journal of Nephrology 16 (4):487–99.
  • Subbu Lakshmi, S., G. Chelladurai, and B. Suresh. 2016. In vitro studies on medicinal plants used against bacterial diabetic foot ulcer (BDFU) and urinary tract infected (UTI) causing pathogens. Journal of Parasitic Diseases 40 (3):667–73. doi: 10.1007/s12639-014-0555-y.
  • Sujithra, K., S. Srinivasan, D. Indumathi, and V. Vinothkumar. 2018. Allyl methyl sulfide, an organosulfur compound alleviates hyperglycemia mediated hepatic oxidative stress and inflammation in streptozotocin - induced experimental rats. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 107:292–302. doi: 10.1016/j.biopha.2018.07.162.
  • Sujithra, K., S. Srinivasan, D. Indumathi, and V. Vinothkumar. 2019. Allyl methyl sulfide, a garlic active component mitigates hyperglycemia by restoration of circulatory antioxidant status and attenuating glycoprotein components in streptozotocin-induced experimental rats. Toxicology Mechanisms and Methods 29 (3):165–76. doi: 10.1080/15376516.2018.1534297.
  • Sultana, M. R., P. K. Bagul, P. B. Katare, S. Anwar Mohammed, R. Padiya, and S. K. Banerjee. 2016. Garlic activates SIRT-3 to prevent cardiac oxidative stress and mitochondrial dysfunction in diabetes. Life Sciences 164:42–51. doi: 10.1016/j.lfs.2016.08.030.
  • Sun, Y. E., W. Wang, and J. Qin. 2018. Anti-hyperlipidemia of garlic by reducing the level of total cholesterol and low-density lipoprotein: A meta-analysis. Medicine 97 (18):e0255. doi: 10.1097/MD.0000000000010255.
  • Takemura, S., Y. Minamiyama, S. Kodai, H. Shinkawa, T. Tsukioka, S. Okada, H. Azuma, and S. Kubo. 2013. S-Allyl cysteine improves nonalcoholic fatty liver disease in type 2 diabetes Otsuka Long-Evans Tokushima Fatty rats via regulation of hepatic lipogenesis and glucose metabolism. Journal of Clinical Biochemistry and Nutrition 53 (2):94–101. doi: 10.3164/jcbn.13-1.
  • Tanaka, T., H. Masuzaki, and K. Nakao. 2006. Adipocyte dysfunction and insulin resistance. Nihon Rinsho 64 (Suppl 9):149–57.
  • Tanti, J. F., and J. Jager. 2009. Cellular mechanisms of insulin resistance: Role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation. Current Opinion in Pharmacology 9 (6):753–62. doi: 10.1016/j.coph.2009.07.004.
  • Tapsell, L. C., I. Hemphill, L. Cobiac, C. S. Patch, D. R. Sullivan, M. Fenech, S. Roodenrys, J. B. Keogh, P. M. Clifton, P. G. Williams, et al. 2006. Health benefits of herbs and spices: The past, the present, the future. The Medical Journal of Australia 185 (S4):S1–S24. doi: 10.5694/j.1326-5377.2006.tb00548.x.
  • Taylor, R. 2008. Pathogenesis of type 2 diabetes: Tracing the reverse route from cure to cause. Diabetologia 51 (10):1781–9. doi: 10.1007/s00125-008-1116-7.
  • Taylor, R. 2019. Calorie restriction for long-term remission of type 2 diabetes. Clinical Medicine 19 (1):37–42. doi: 10.7861/clinmedicine.19-1-37.
  • Taylor, R. 2021. Type 2 diabetes and remission: Practical management guided by pathophysiology. Journal of Internal Medicine 289 (6):754–70. doi: 10.1111/joim.13214.
  • Taylor, R., A. Al-Mrabeh, S. Zhyzhneuskaya, C. Peters, A. C. Barnes, B. S. Aribisala, K. G. Hollingsworth, J. C. Mathers, N. Sattar, and M. E. J. Lean. 2018. Remission of human type 2 diabetes requires decrease in liver and pancreas fat content but is dependent upon capacity for β cell recovery. Cell Metabolism 28 (4):547–56.e3. doi: 10.1016/j.cmet.2018.07.003.
  • Thomson, M., K. K. Al-Qattan, D. Js, and M. Ali. 2016. Anti-diabetic and anti-oxidant potential of aged garlic extract (AGE) in streptozotocin-induced diabetic rats. BMC Complementary and Alternative Medicine 16:17. doi: 10.1186/s12906-016-0992-5.
  • Thorens, B. 2015. GLUT2, glucose sensing and glucose homeostasis. Diabetologia 58 (2):221–32. doi: 10.1007/s00125-014-3451-1.
  • Tilg, H., T. E. Adolph, M. Dudek, and P. Knolle. 2021. Non-alcoholic fatty liver disease: The interplay between metabolism, microbes and immunity. Nature Metabolism 3 (12):1596–607. doi: 10.1038/s42255-021-00501-9.
  • Towler, M. C., and D. G. Hardie. 2007. AMP-activated protein kinase in metabolic control and insulin signaling. Circulation Research 100 (3):328–41. [Database] doi: 10.1161/01.RES.0000256090.42690.05.
  • Toygar, I., A. Tureyen, D. Demir, and S. Cetinkalp. 2020. Effect of allicin on wound healing: An experimental diabetes model. Journal of Wound Care 29 (7):388–92. doi: 10.12968/jowc.2020.29.7.388.
  • Tremblay, F., M. J. Dubois, and A. Marette. 2003. Regulation of GLUT4 traffic and function by insulin and contraction in skeletal muscle. Frontiers in Bioscience: A Journal and Virtual Library 8:d1072–84. doi: 10.2741/1137.
  • Tsai, C. Y., C. C. Wang, T. Y. Lai, H. N. Tsu, C. H. Wang, H. Y. Liang, and W. W. Kuo. 2013. Antioxidant effects of diallyl trisulfide on high glucose-induced apoptosis are mediated by the PI3K/Akt-dependent activation of Nrf2 in cardiomyocytes. International Journal of Cardiology 168 (2):1286–97. doi: 10.1016/j.ijcard.2012.12.004.
  • Tsai, C. Y., S. Y. Wen, M. A. Shibu, Y. C. Yang, H. Peng, B. Wang, Y. M. Wei, H. Y. Chang, C. Y. Lee, C. Y. Huang, et al. 2015. Diallyl trisulfide protects against high glucose-induced cardiac apoptosis by stimulating the production of cystathionine gamma-lyase-derived hydrogen sulfide. International Journal of Cardiology 195:300–10. doi: 10.1016/j.ijcard.2015.05.111.
  • Tsompanidi, E. M., M. S. Brinkmeier, E. H. Fotiadou, S. M. Giakoumi, and K. E. Kypreos. 2010. HDL biogenesis and functions: Role of HDL quality and quantity in atherosclerosis. Atherosclerosis 208 (1):3–9. doi: 10.1016/j.atherosclerosis.2009.05.034.
  • Vallon, V., and T. Nakagawa. 2021. Renal tubular handling of glucose and fructose in health and disease. Comprehensive Physiology 12:2995–3044.
  • van de Wouw, M., H. Schellekens, T. G. Dinan, and J. F. Cryan. 2017. Microbiota-gut-brain axis: Modulator of host metabolism and appetite. The Journal of Nutrition 147 (5):727–45. doi: 10.3945/jn.116.240481.
  • van Sloten, T. T., S. Sedaghat, M. R. Carnethon, L. J. Launer, and C. D. A. Stehouwer. 2020. Cerebral microvascular complications of type 2 diabetes: Stroke, cognitive dysfunction, and depression. The Lancet. Diabetes & Endocrinology 8 (4):325–36. doi: 10.1016/S2213-8587(19)30405-X.
  • Venkataiah, V., K. R. Thirumalarao, V. G. Raiker, S. H. Puttaswamy, and, Vickram. 2016. Effects of diaceto-dipropyl-disulphide on plasma sialic acid and renal tissue thiol levels in alloxan diabetic rats. Journal of Clinical and Diagnostic Research: JCDR 10 (6):Bf06–8. doi: 10.7860/JCDR/2016/19241.8058.
  • Wahlström, A., S. I. Sayin, H. U. Marschall, and F. Bäckhed. 2016. Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism. Cell Metabolism 24 (1):41–50. doi: 10.1016/j.cmet.2016.05.005.
  • Wang, B., and P. Tontonoz. 2018. Liver X receptors in lipid signalling and membrane homeostasis. Nature Reviews. Endocrinology 14 (8):452–63. doi: 10.1038/s41574-018-0037-x.
  • Wang, C. H., C. C. Wang, H. C. Huang, and Y. H. Wei. 2013. Mitochondrial dysfunction leads to impairment of insulin sensitivity and adiponectin secretion in adipocytes. The FEBS Journal 280 (4):1039–50. doi: 10.1111/febs.12096.
  • Wang, C. H., and Y. H. Wei. 2020. Roles of mitochondrial sirtuins in mitochondrial function, redox homeostasis, insulin resistance and type 2 diabetes. International Journal of Molecular Sciences 21 (15):5266. doi: 10.3390/ijms21155266.
  • Wang, G. G., and W. Li. 2019. Hydrogen sulfide improves vessel formation of the ischemic adductor muscle and wound healing in diabetic db/db mice. Iranian Journal of Basic Medical Sciences 22 (10):1192–7. doi: 10.22038/ijbms.2019.36551.8709.
  • Wang, H. X., 2011. Effect of allicin on apoptosis mechanism of cerebral ischemia-reperfusion injury in diabetic rats. CHKD National Database of Scientific and Technological Achievementss. Accessed December 03, 2022. https://kns.cnki.net/kcms/detail/detail.aspx? dbcode=SNAD&dbname=SNAD&filename=SNAD000001469485&uniplatform=NZKP T&v=TjRX_0fSS4uiFKP U64aX4MBJztgB050Y4v6DsiOsi-K7UK-bVNP GRNx74So5wLGt2cTIvXvlKM%3d.
  • Wang, W. H., G. P. He, X. P. Xiao, C. Gu, and H. Y. Chen. 2012. Relationship between brain-derived neurotrophic factor and cognitive function of obstructive sleep apnea/hypopnea syndrome patients. Asian Pacific Journal of Tropical Medicine 5 (11):906–10. doi: 10.1016/S1995-7645(12)60169-2.
  • Wang, X., R. Cade, and Z. Sun. 2005. Expression of human eNOS in cardiac and endothelial cells. Methods in Molecular Medicine 112:91–107. doi: 10.1007/978-1-59259-879-3_7.
  • Wang, Y., J. Viscarra, S. J. Kim, and H. S. Sul. 2015. Transcriptional regulation of hepatic lipogenesis. Nature Reviews. Molecular Cell Biology 16 (11):678–89. doi: 10.1038/nrm4074.
  • Wlosinska, M., A. C. Nilsson, J. Hlebowicz, M. Malmsjö, M. Fakhro, and S. Lindstedt. 2019. Aged garlic extract preserves cutaneous microcirculation in patients with increased risk for cardiovascular diseases: A double-blinded placebo-controlled study. International Wound Journal 16 (6):1487–93. doi: 10.1111/iwj.13220.
  • Yadav, A., M. A. Kataria, V. Saini, and A. Yadav. 2013. Role of leptin and adiponectin in insulin resistance. Clinica Chimica Acta; International Journal of Clinical Chemistry 417:80–4. doi: 10.1016/j.cca.2012.12.007.
  • Yamagishi, S. I., N. Nakamura, and T. Matsui. 2017. Glycation and cardiovascular disease in diabetes: A perspective on the concept of metabolic memory. Journal of Diabetes 9 (2):141–8. doi: 10.1111/1753-0407.12475.
  • Yang, F., Y. Qin, J. Lv, Y. Wang, H. Che, X. Chen, Y. Jiang, A. Li, X. Sun, E. Yue, et al. 2018. Silencing long non-coding RNA Kcnq1ot1 alleviates pyroptosis and fibrosis in diabetic cardiomyopathy. Cell Death & Disease 9 (10):1000. doi: 10.1038/s41419-018-1029-4.
  • Yang, H. B., H. M. Liu, J. C. Yan, and Z. Y. Lu. 2018. Effect of diallyl trisulfide on ischemic tissue injury and revascularization in a diabetic mouse model. Journal of Cardiovascular Pharmacology 71 (6):367–74. doi: 10.1097/FJC.0000000000000579.
  • Yang, J., T. Wang, J. Yang, K. Rao, Y. Zhan, R. B. Chen, Z. Liu, M. C. Li, L. Zhuan, G. H. Zang, et al. 2013. S-allyl cysteine restores erectile function through inhibition of reactive oxygen species generation in diabetic rats. Andrology 1 (3):487–94. doi: 10.1111/j.2047-2927.2012.00060.x.
  • Yang, Q., H. Gao, R. Dong, and Y. Q. Wu. 2016. Sequential changes of endoplasmic reticulum stress and apoptosis in myocardial fibrosis of diabetes mellitus-induced rats. Molecular Medicine Reports 13 (6):5037–44. doi: 10.3892/mmr.2016.5180.
  • Yang, W. S., and B. R. Stockwell. 2016. Ferroptosis: Death by lipid peroxidation. Trends in Cell Biology 26 (3):165–76. doi: 10.1016/j.tcb.2015.10.014.
  • Ye, J. 2013. Mechanisms of insulin resistance in obesity. Frontiers of Medicine 7 (1):14–24. doi: 10.1007/s11684-013-0262-6.
  • Ye, Y., Y. Birnbaum, S. G. Widen, Z. Zhang, S. Zhu, M. Bajaj, and H. Chen. 2020. Acupuncture reduces hypertrophy and cardiac fibrosis, and improves heart function in mice with diabetic cardiomyopathy. Cardiovascular Drugs and Therapy 34 (6):835–48. doi: 10.1007/s10557-020-07043-4.
  • Yoo, M., S. Kim, S. Lee, and D. Shin. 2014. Validated HPLC method and temperature stabilities for oil-soluble organosulfur compounds in garlic macerated oil. Journal of Chromatographic Science 52 (10):1165–72. doi: 10.1093/chromsci/bmt166.
  • Yu, L., W. Di, X. Dong, Z. Li, X. Xue, J. Zhang, Q. Wang, X. Xiao, J. Han, Y. Yang, et al. 2017. Diallyl trisulfide exerts cardioprotection against myocardial ischemia-reperfusion injury in diabetic state, role of AMPK-mediated AKT/GSK-3β/HIF-1α activation. Oncotarget 8 (43):74791–805. doi: 10.18632/oncotarget.20422.
  • Yu, L., S. Li, X. Tang, Z. Li, J. Zhang, X. Xue, J. Han, Y. Liu, Y. Zhang, Y. Zhang, et al. 2017. Diallyl trisulfide ameliorates myocardial ischemia-reperfusion injury by reducing oxidative stress and endoplasmic reticulum stress-mediated apoptosis in type 1 diabetic rats: Role of SIRT1 activation. Apoptosis: An International Journal on Programmed Cell Death 22 (7):942–54. doi: 10.1007/s10495-017-1378-y.
  • Yuko, O. O., and M. Saito. 2021. Brown fat as a regulator of systemic metabolism beyond thermogenesis. Diabetes & Metabolism Journal 45 (6):840–52. doi: 10.4093/dmj.2020.0291.
  • Yuvashree, M., R. N. Ganesh, and P. Viswanathan. 2020. Potential application of nanoemulsified garlic oil blend in mitigating the progression of type 2 diabetes-mediated nephropathy in Wistar rats. 3 Biotech 10 (6):272. doi: 10.1007/s13205-020-02262-w.
  • Yuvashree, M., R. Gokulakannan, R. N. Ganesh, and P. Viswanathan. 2019. Enhanced therapeutic potency of nanoemulsified garlic oil blend towards renal abnormalities in pre-diabetic rats. Applied Biochemistry and Biotechnology 188 (2):338–56. doi: 10.1007/s12010-018-2919-8.
  • Zanchi, D., A. Depoorter, L. Egloff, S. Haller, L. Mählmann, U. E. Lang, J. Drewe, C. Beglinger, A. Schmidt, and S. Borgwardt. 2017. The impact of gut hormones on the neural circuit of appetite and satiety: A systematic review. Neuroscience and Biobehavioral Reviews 80:457–75. doi: 10.1016/j.neubiorev.2017.06.013.
  • Zeng, H., S. Umar, B. Rust, D. Lazarova, and M. Bordonaro. 2019. Secondary bile acids and short chain fatty acids in the colon: A focus on colonic microbiome, cell proliferation, inflammation, and cancer. International Journal of Molecular Sciences 20 (5):1214. doi: 10.3390/ijms20051214.
  • Zeng, W., R. M. Pirzgalska, M. M. Pereira, N. Kubasova, A. Barateiro, E. Seixas, Y. H. Lu, A. Kozlova, H. Voss, G. G. Martins, et al. 2015. Sympathetic neuro-adipose connections mediate leptin-driven lipolysis. Cell 163 (1):84–94. doi: 10.1016/j.cell.2015.08.055.
  • Zeng, Y., W. W. Du, Y. Wu, Z. Yang, F. M. Awan, X. Li, W. Yang, C. Zhang, Q. Yang, A. Yee, et al. 2017. A circular RNA binds to and activates AKT phosphorylation and nuclear localization reducing apoptosis and enhancing cardiac repair. Theranostics 7 (16):3842–55. doi: 10.7150/thno.19764.
  • Zhai, B., C. Zhang, Y. Sheng, C. Zhao, X. He, W. Xu, K. Huang, and Y. Luo. 2018. Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice. Scientific Reports 8 (1):3527. doi: 10.1038/s41598-018-21421-x.
  • Zhang, W. 2021. Bifunctional iron sulfide nanozyme for the treatment of chronic wound infection in diabetic mice. Yangzhou University.
  • Zhang, X. D., and Z. Y. Chen. 2019. Effects of allitridi on insulin resistance and adipokines of the rats with streptozotocin-induced diabetes mellitus. Western Journal of Traditional Chinese Medicine 32:23–6.
  • Zhang, Y., R. Proenca, M. Maffei, M. Barone, L. Leopold, and J. M. Friedman. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature 372 (6505):425–32. doi: 10.1038/372425a0.
  • Zhang, Y., G. Wang, Y. Kong, H. Xu, B. Xiao, Y. Liu, and H. Zhou. 2020. A comparative analysis of the essential oils from two species of garlic seedlings cultivated in China: Chemical profile and anticoagulant potential. Food & Function 11 (7):6020–7. doi: 10.1039/d0fo00845a.
  • Zhang, Z., Y. Gao, and Z. X. Meng. 2022. Transcriptional control of pancreatic β-cell identity and plasticity during the pathogenesis of type 2 diabetes. Journal of Genetics and Genomics = Yi Chuan Xue Bao 49 (4):316–28. doi: 10.1016/j.jgg.2022.03.002.
  • Zhao, Y., X. Hu, Y. Liu, S. Dong, Z. Wen, W. He, S. Zhang, Q. Huang, and M. Shi. 2017. ROS signaling under metabolic stress: Cross-talk between AMPK and AKT pathway. Molecular Cancer 16 (1):79. doi: 10.1186/s12943-017-0648-1.
  • Ziamajidi, N., H. Behrouj, R. Abbasalipourkabir, and F. Lotfi. 2018. Ameliorative effects of allium sativum extract on iNOS gene expression and NO production in liver of streptozotocin + nicotinamide-induced diabetic rats. Indian Journal of Clinical Biochemistry: IJCB 33 (2):147–53. doi: 10.1007/s12291-017-0656-3.
  • Ziamajidi, N., A. Nasiri, R. Abbasalipourkabir, and S. Sadeghi Moheb. 2017. Effects of garlic extract on TNF-α expression and oxidative stress status in the kidneys of rats with STZ + nicotinamide-induced diabetes. Pharmaceutical Biology 55 (1):526–31. doi: 10.1080/13880209.2016.1255978.
  • Ziller, N., R. Kotolloshi, M. Esmaeili, M. Liebisch, R. Mrowka, A. Baniahmad, T. Liehr, G. Wolf, and I. Loeffler. 2020. Sex differences in diabetes- and TGF-β1-Induced renal damage. Cells 9 (10):2236. doi: 10.3390/cells9102236.
  • Zilliox, L. A., K. Chadrasekaran, J. Y. Kwan, and J. W. Russell. 2016. Diabetes and cognitive impairment. Current Diabetes Reports 16 (9):87. doi: 10.1007/s11892-016-0775-x.
  • Zorena, K., O. Jachimowicz-Duda, D. Ślęzak, M. Robakowska, and M. Mrugacz. 2020. Adipokines and obesity. Potential link to metabolic disorders and chronic complications. International Journal of Molecular Sciences 21 (10):3570. doi: 10.3390/ijms21103570.

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