The role of free radicals and antioxidants: How do we know that they are working?

References

• Burton , G. W. , Doba , T. , Gabe , E. , Hughes , L. , Lee , F. L. , Prasad , L. and Ingold , K. U. 1985 . Autoxidation of biological molecules. IV. Maximizing the antioxidant activity of phenols . J. Am. Chem. Soc. , 107 : 7053
   Web of Science ®Google Scholar
• Howard , J. A. and Ingold , K. U. 1966 . Absolute rate constants for hydrocarbon autoxidation. VI. Alkyl, aromatic and olefinic hydrocarbons . Can. J. Chem. , 45 : 793
   Google Scholar
• Barday , L. R. C. , Baskin , K. A. , Locke , S. J. and Vinqvist , M. R. 1989 . Absolute rate constants for lipid peroxidation inhibition in model biomembranes . Can. J. Chem. , 67 : 1366
   Google Scholar
• Barclay , L. R.C. , Baskin , K. A. , Dakin , K. A. , Locke , S. J. and Vinqvist , M. R. 1990 . The antioxidant activities of phenolic antioxidants in free radical peroxidation of phospholipid membranes . Can. J. Chem. , 68 : 2258
   Web of Science ®Google Scholar
• Ingold , K. U. , Bowry , V. W. , Stacker , R. and Walling , C. 1993 . Autoxidation of lipids and antioxidation by α‐tocopherol and ubiquinol in homogeneous solution and in aqueous dispersions of lipids: unrecognized consequences of lipid particle size as exemplified by oxidation of human low density lipoprotein . Proc. Natl. Acad. Sci., USA. , 90 : 45
   PubMed Web of Science ®Google Scholar
• Nagaoka , S. , Okauchi , Y. , Urano , S. , Nagashima , U. and Mukai , K. Kinetic . 1990 . ab initio study of the prooxidant effect of vitamin E. Hydrogen abstraction from fatty acid esters and egg lecithin . J. Am. Chem. Soc. , 112 : 8921
   Web of Science ®Google Scholar
• Packer , J. E. , Slater , T. F. and Willson , R. L. 1979 . Direct observation of a free radical interaction between vitamin E and vitamin C. . Nature (London) , 278 : 737
   PubMed Web of Science ®Google Scholar
• Sato , K. , Niki , E. and Shimasaki , H. 1990 . Free radical‐mediated chain oxidation of low density lipoprotein and its synergistic inhibition by vitamin E and vitamin C. . 279 : 402
   Google Scholar
• Inglett , G. E. and Mattill , H. A. 1955 . Oxidation of hindered 6‐hydroxychromans . J. Am. Chem. Soc. , 77 : 6552
   Google Scholar
• Skinner , W. A. and Parkhurst , R. M. 1966 . Oxidation products of vitamin E and its model, 6‐hydroxy‐2,2,5,7,8‐penta‐methylchroman. VII. Oxidation with benzoyl peroxide . J. Am. Chem. Soc. , 31 : 1248
   Google Scholar
• Skoarna , C. , Craig , D. C. , Cross , K. J. and Southwell‐Dedy , P. T. 1988 . Oxidations of Vitamin E (α‐tocopherol) and its model compound 2,2,5,7,8‐pentamethyl‐6‐hydroxychroman. A new dimer . J. Am. Chem. Soc. , 88 : 1281
   Google Scholar
• Stocker , R. , Bowry , V. W. and Frei , B. 1991 . Ubiquinol‐10 protects human low density lipoprotein more efficiently against lipid peroxidation than does α‐tocopherol . Proc. Natl. Acad. Sci. U.S.A. , 88 : 1646
   PubMed Web of Science ®Google Scholar
• Sato , K. , Niki , E. and Shimasaki , H. 1990 . Free radical mediated chain oxidation of low density lipoprotein and its synergistic inhibition by vitamin E and vitamin C. . Arch. Biochem. Biophys. , 279 : 402
   PubMed Web of Science ®Google Scholar
• Foote , C. S. and Denny , R. W. 1968 . Chemistry of singlet oxygen. VII. Quenching by β‐carotene . J. Am. Chem. Soc. , 90 : 6233
   Web of Science ®Google Scholar
• Burton , G. W. and Ingold , K. U. 1984 . β‐Carotene: an unusual type of lipid antioxidant. . Science , 224 : 569
   PubMed Web of Science ®Google Scholar
• Kennedy , T. A. and Liebler , D. C. 1992 . Peroxyl radical scavenging by β‐carotene in lipid bilayers. Effect of oxygen partial pressures . J. Biol. Chem. , 267 : 4658
   PubMed Web of Science ®Google Scholar
• Tsuchiya , M. , Scita , G. , Freisleben , H. J. , Kagan , V. E. and Packer , L. 1992 . Antioxidant radical‐scavenging activity of carotenoids and retinoids compared to α‐tocopherol . Methods Enzymol. , 213 : 460
   PubMed Web of Science ®Google Scholar
• Palozza , P. and Krinsky , N. I. 1992 . Antioxidant effects of carotenoids in vivo and in vitro: an overview . Methods Enzymol. , 213 : 403
   PubMed Web of Science ®Google Scholar
• Palozza , P. , Moualla , S. and Krinsky , N. 1992 . Effects of β‐carotene and α‐tocopherol on radical initiated peroxidation of microsomes . Free Rad. Biol. Med. , 13 : 127
   PubMed Web of Science ®Google Scholar
• Stocker , R. , Yamamoto , Y. , McDonagh , A. F. , Glazer , A. N. and Ames , B. N. 1987 . Bilirubin is an antioxidant of possible physiological importance. . Science , 235 : 1043
   PubMed Web of Science ®Google Scholar
• Flohé , L. , Loschen , G. , Günzler , W. A. and Eichele , E. 1972 . Glutathione peroxidase. V. The kinetic mechanism . Hoppe‐Seyler's Z. Physiol. Chem. , 353 : 987
   PubMedGoogle Scholar
• Ursini , F. , Maiorino , M. and Gregolin , C. 1985 . The selenoenzyme phospholipid hydroperoxide glutathione peroxidase . Biochim. Biophys. Acta , 839 : 62
   PubMed Web of Science ®Google Scholar
• Van Kuijk , F. J. G. M. , Sevanian , A. , Handelman , G. and Dratz , E. A. 1987 . A new role for phospholipase A2 . Trends Biochem. Sci. , 12 : 31
   Web of Science ®Google Scholar
• Britigan , B. E. , Rosen , G. M. , Thompson , B. Y. , Chai , Y. and Cohen , M. S. 1986 . Stimulated human neutrophils limit iron‐catalyzed hydroxyl radical formation as detected by spin‐trapping techniques . J. Biol. Chem. , 261 : 17026
   PubMed Web of Science ®Google Scholar
• Comporti , M. 1985 . Lipid peroxidation and cellular damage in toxic liver injury . Lab. Invest. , 53 : 599
   PubMed Web of Science ®Google Scholar
• Gardner , H. W. 1989 . Oxygen radical chemistry of polyunsatu‐rated fatty acids . Free Rad. Biol. Med. , 7 : 65
   PubMed Web of Science ®Google Scholar
• Dix , T. A. and Marnett , L. J. 1985 . Conversion of linoleic acid hydroperoxide to hydroxy, keto, epoxyhydroxy, and trihydroxy fatty acids by hematin . J. Biol. Chem. , 260 : 5351
   PubMed Web of Science ®Google Scholar
• Pryor , W. A. , Stanley , J. P. and Baair , E. 1976 . Autoxidation of polyunsaturated fatty acids: ?. A suggested mechanism for the formation of TBA‐reactive material from prostaglandin‐like endoperoxides . Lipids , 11 : 370
   PubMed Web of Science ®Google Scholar
• O'Connor , D. E. , Mikelich , E. D. and Coleman , M. C. 1984 . Stereochemical course of the autoxidative cyclization of lipid hydroperoxide to prostaglandin‐like bicyclo endoperoxides . J. Am. Chem. Soc. , 106 : 3577
   Web of Science ®Google Scholar
• Morrow , J. D. , Hill , K. E. , Burk , R. F. , Namraour , T. M. , Badr , K. F. and Roberts , L. J. 1990 . A series of prostaglandin Fα‐like compounds are produced in vivo in humans by a non‐cyclooxygenase, free radical catalyzed mechanism . Proc. Natl. Acad. Sci. USA. , 87 : 9383
   PubMed Web of Science ®Google Scholar
• Roehm , J. N. , Hadley , J. G. and Menzel , D. B. 1971 . Oxidation of unsaturated fatty acids by ozone and NO2 . Arch. Environ. Health , 23 : 142
   PubMed Web of Science ®Google Scholar
• Dahle , L. K. , Hill , E. G. and Holman , R. T. 1962 . The thiobarbituric acid reaction and the autoxidations of polyunsaturated fatty acid methyl esters . Arch. Biochem. Biophys. , 98 : 253
   PubMed Web of Science ®Google Scholar
• Steenken , S. 1989 . Purine bases, nucleosides, and nucleotides: aqueous solution redox chemistry and transformation reactions of their radical cations and e‐ and OH adducts . Chem. Rev. , 89 : 503
   Web of Science ®Google Scholar
• Saul , R. L. and Ames , B. N. 1986 . Background levels of DNA damage in the population, Basic . Life Sci. , 38 : 529
   Google Scholar
• Ide , H. , Kow , Y. W. and Wallace , S. S. 1985 . Thymine glycol and urea residues in M13 DNA constitute replicative blocks in vitro . Nucleic Acids Res. , 13 : 8035
   PubMed Web of Science ®Google Scholar
• Cheng , K. C. , Cahill , D. S. , Kasai , H. , Nishimura , S. and Loeb , L.A. 1992 . 8‐Hydroxyguanine, an abundant form of oxidative DNA damage, causes G A and A C substitutions . J. Biol. Chem. , 267 : 166
   PubMed Web of Science ®Google Scholar
• Dizdaroglu , M. 1984 . The use of capillary gas chromatography mass spectrometry for identification of radiation‐induced DNA base damage and DNA base‐amino acid cross‐links . J. Chromatog. , 295 : 103
   PubMed Web of Science ®Google Scholar
• Dizdaroglu , M. and Bergtold , D. S. 1986 . Characterization of free radical‐induced base damage in DNA at biolologically relevant levels . Anal. Biochem. , 156 : 182
   PubMed Web of Science ®Google Scholar
• Aruoma , O. I. , Halliwell , B. , Gajewski , E. and Dizdaroglu , M. 1989 . Damage to bases in DNA induced by hydrogen peroxide and ferric ion chelates . J. Biol. Chem. , 264 : 20509
   PubMed Web of Science ®Google Scholar
• Tullius , T. D. and Dombroski , B. A. 1986 . Hydroxyl radical “footprinting”;: high‐resolution information about DNA‐protein contacts and application to λ repressor and Cro protein . Proc. Natl. Acad. Sci. USA. , 83 : 5469
   PubMed Web of Science ®Google Scholar
• Pryor , W. A. 1986 . Oxy‐radicals and related species: their formation, lifetimes and reactions . Annu. Rev. Physiol. , 48 : 657
   PubMed Web of Science ®Google Scholar
• McCay , P. B. 1987 . Application of ESR spectroscopy in toxicology . Arch. Toxicol. , 60 : 133
   PubMedGoogle Scholar
• Misra , H. P. and Fridorich , I. 1972 . The generation of superoxide radical during the autoxidation of hemoglobin . J. Biol. Chem. , 247 : 6960
   PubMed Web of Science ®Google Scholar
• Boveris , A. and Cadenas , A. 1975 . Mitochondrial production of Superoxide anions and its relationship to antimycin insensitive respiration . FEBS Lett. , 54 : 311
   PubMed Web of Science ®Google Scholar
• Dionisi , O. , Galeotti , T. , Terranova , T. and Azzi , A. 1975 . Superoxide radicals and hydrogen peroxide formation in mitochondria from normal and neoplastic tissues . Biochem. Biophys. Acta , 403 : 292
   PubMed Web of Science ®Google Scholar
• Loschen , G. , Azri , A. , Richter , C. and Flohé , L. 1974 . Superoxide radicals as precursors of mitochondrial hydrogen peroxide . FEBS Lett. , 42 : 68
   PubMed Web of Science ®Google Scholar
• Boveris , A. and Cadenas , A. 1982 . “ Production of Superoxide radicals and hydrogen peroxide in mitochondria ” . In Superoxide Dismutase , Edited by: Oberley , L. W. Vol. 2 , 15 Boca Raton, FL : CRC Press .
   Google Scholar
• Bielski , B. H. J. , Cabelli , D. E. , Arudi , R. L. and Ross , A. B. 1985 . Reactivity of HO2/O‐ 2 radicals in aqueous solution . Phys. Chem. Ref. Data , 14 : 1041
   Web of Science ®Google Scholar
• Gardner , P. R. and Fridovich , L. 1991 . Superoxide sensitivity of the Escherichia coli aconitase . J. Biol. Chem. , 266 : 19328
   PubMed Web of Science ®Google Scholar
• Babior , B. M. 1984 . Oxidants from phagocytes: agents of defense and destruction . Blood , 64 : 959
   PubMed Web of Science ®Google Scholar
• Agner , K. 1963 . Studies on myeloperoxidase activity. I. Spectrophotometry of the HPO‐H2O2 compound . Acta Chem. Scand. , 17 : 332
   Google Scholar
• Long , C. A. and Bielski , B. H. J. 1980 . Rate of reaction of Superoxide radical with chloride‐containing species . J. Phys. Chem. , 84 : 555
   Web of Science ®Google Scholar
• Thomas , M. J. , Shirley , P. S. , Hedrick , C. and DeChatelet , L. R. 1986 . Role of free radical processes in stimulated human polymorphonuclear leukocytes. . Biochemistry , 25 : 8042
   PubMed Web of Science ®Google Scholar
• Pou , S , Cohen , B. E. , Britigan , B. E. and Rosen , G. M. 1989 . Spin‐trapping and human neutrophils . J. Biol. Chem. , 264 : 12299
   PubMed Web of Science ®Google Scholar
• Kaur , H. , Fagerheim , I. , Grootveld , M. , Puppo , E. and Halliwell , B. 1988 . Aromatic hydroxylation of phenylalanine as an assay for hydroxyl radical: applications to activated human neutrophils and to heme protein leghemoglobin . Anal. Biochem. , 172 : 360
   PubMed Web of Science ®Google Scholar
• Winterborn , C. C. 1986 . Mydopcroxidase as an effective inhibitor of hydroxyl radical production. . J. Clin. Invest. , 78 : 545
   PubMedGoogle Scholar
• Khan , A. U. and Kasha , M. 1963 . Red chemiluminescence of molecular oxygen in aqueous solution . J. Chem. Phys. , 39 : 2105
   Web of Science ®Google Scholar
• Kanofsky , J. R. , Hoogland , H. , Wever , R. and Weiss , S. J. 1988 . Singlet oxygen production by human eosinophils . J. Biol. Chem. , 263 : 9692
   PubMed Web of Science ®Google Scholar
• Foote , C. S. , Abakerli , R.?. , Clough , R. L. and Shook , F. C. 1980 . On the question of singlet oxygen production in leukocytes, macrophages and the dismutation of Superoxide ion . Dev. Biochem. , IIB : 222
   Google Scholar
• Steinbeck , M. J. , Khan , A. U. and Karnovsky , M. J. 1992 . Intracellular singlet oxygen generation by phagocytosing neutrophils in response to particles coated with a chemical trap . J. Biol. Chem. , 267 : 13425
   PubMed Web of Science ®Google Scholar
• Smith , R. M. and Curnutte , J. T. 1991 . Molecular basis of chronic granulomatous disease . Blood , 32 : 673
   Google Scholar
• O'Flaherty , J. T. , Thomas , M. J. , Lees , C. J. and McCall , C. E. 1981 . Neutrophil‐aggregating activity of monohydroxyeicosatetraenoic acids . Am. J. Pathol. , 104 : 55
   PubMedGoogle Scholar
• Thomas , M. J. , O'FIaherty , J. T. , Cousart , S. and McCall , C. E. 1982 . The effect of free radical derived hydroxyicosatetraenoic acids on hexose transport in the human polymorphonaclear leukocyte . Prostaglandins , 23 : 265
   PubMedGoogle Scholar
• Gräslund , A. , Sahlin , M. and Sjöberg , ?. M. 1985 . The tyrosyl free radical in ribonucleotide reducíase . Environ. Health Perspect. , 64 : 139
   PubMed Web of Science ®Google Scholar
• Hibbs , J. B. , Tanitor , R. R. , Vavrin , Z. and Rachlin , E. M. 1988 . Nitric oxide: a cytotoxic activated macrophage effector molecule . Biochem. Biophys. Res. Commun. , 157 : 87
   PubMed Web of Science ®Google Scholar
• Ignarro , L. J. , Byrns , R. E. and Woops , K. S. 1988 . “ Biochemical and pharmacological properties of endothelium‐derived relaxing factor and its similarity to nitric oxide radical ” . In Mechanisms of Vasodilation , Edited by: Vanhoutte , P. M. 427 New York : Raven Press .
   Google Scholar
• Furchogott , R. F. 1988 . “ Studies on relaxation of rabbit aorta by sodium nitrite: the basis for the proposal that the acid‐activatable factor from bovine retractor penis is inorganic nitrite and the endothelium‐derived relaxing factor is nitric oxide radical ” . In Mechanisms of Vasodilatation , Edited by: Vanhoutte , P. M. 401 New York : Raven Press .
   Google Scholar
• Ignarro , L. J. 1990 . Biosynthesis and metabolism of endothelium‐derived nitric oxide . Annu. Rev. Pharmacol. Toxicol. , 30 : 535
   PubMed Web of Science ®Google Scholar
• Moncada , S. , Palmer , R. M. J. and Higgs , E. A. 1991 . Nitric oxide: physiology, pathophysiology, and pharmacology . J. Pharmacol. Exp. Ther. , 43 : 109
   Google Scholar
• Tayeh , M. A. and Marietta , ?. ?. 1989 . Macrophage oxidation of L‐arginine to nitric oxide, nitrite, and nitrate: tetrahydroxybiopterin is required as a cofactor . J. Biol. Chem. , 64 : 19654
   Google Scholar
• Beckman , J. S. , Beckman , T. W. , Chen , J. , Marshall , P. A. and Freeman , ?. ?. 1990 . Apparent hydroxyl radical production by peroxynitrite: implication for endothelial injury from nitric oxide and Superoxide . Proc. Natl. Acad. Sci., USA. , 87 : 1620
   PubMed Web of Science ®Google Scholar
• Mahoney , L. R. 1970 . Evidence for the formation of hydroxyl radicals in the isomerization of pernitrous acid to nitric acid in aqueous solution . J. Am. Chem. Soc. , 92 : 5262
   Web of Science ®Google Scholar
• Koppenol , W.H. , Moreno , J. J. , Pryor , W. ?. , Ischiropoulos , H. and Beckman , J. S. 1992 . Peroxynitrite, a cloaked oxidant formed by nitric oxide and Superoxide . Chem. Res. Toxicol. , 5 : 834
   PubMed Web of Science ®Google Scholar
• Acton , J. D. and Myrvik , Q. N. 1972 . Nitrogen dioxide effects on alveolar macrophage . Arch. Environ. Health , 24 : 482
   Google Scholar
• Robison , T. W. , Murphy , J. K. , Beyer , L. L. , Richters , A. and Forman , ?. J. 1993 . Depression of stimulated arachidonate metabolism and Superoxide production in rat alveolar macrophage following in vivo exposure to 0.5 ppm NO2 stimulated by A23187 . J. Toxicol. Environ. Health , 38 : 273
   PubMed Web of Science ®Google Scholar
• Robison , T. W. and Forman , H. J. 1993 . Dual effect of nitrogen dioxide on rat alveolar macrophage arachidonate metabolism . 19 : 21
   Google Scholar
• Pryor , W. A. and Lightsey , J. W. 1981 . Mechanisms of nitrogen dioxide reactions: Initiation of lipid peroxidation and the production of nitrous acid. . Science , 214 : 435
   PubMed Web of Science ®Google Scholar
• Roehm , J. N. , Hadley , J. G. and Menzel , D. B. 1971 . Antioxi‐dants vs. lung disease. . Arch. Intern. Med. , 128 : 88
   PubMed Web of Science ®Google Scholar
• Felmeister , A. , Amanal , M. and Weiner , N. D. 1968 . Interactions of NO2‐olefin gas mixtures with lecithin monomolecular films. . Environ. Sci. Technol. , 2 : 40
   Google Scholar
• Pryor , W. A. , Lightsey , J. W. and Church , D. F. 1982 . Reaction of nitrogen dioxide with alkenes and polyunsaturated fatty acids: addition and hydrogen abstraction mechanisms . J. Am. Chem. Soc. , 104 : 6685
   Web of Science ®Google Scholar
• Estefon , R. M. , Gause , E. M. and Rowlands , J. R. 1970 . Electron spin resonance and optical studies of the interactions between NO2 and unsaturated lipid components . Environ. Res. , 3 : 62
   PubMedGoogle Scholar
• Carman , P. C. 1970 . Electron spin resonance of radicals formed in the reaction of nitrogen dioxide with olefins . J. Phys. Chem. , 74 : 1650
   Google Scholar
• Thomas , H. V. , Mueller , P. K. and Lyman , R. L. 1968 . Lipoperoxidation of lung lipids in rats exposed to NO2 . Science , 159 : 532
   PubMed Web of Science ®Google Scholar
• Sagai , M. , Ichinose , T. and Kubota , K. 1984 . Studies on the biochemical effects of nitrogen dioxide. IV. Relation between the change of lipid peroxidation and the antioxidative protective system in rat lungs upon life span exposure to low levels of NO2 . Toxicol. Appl. Pharmacol. , 73 : 444
   PubMed Web of Science ®Google Scholar
• Seranian , A. , Mead , J. F. and Stein , R. A. 1979 . Epoxides as products of lipid autoxidation in rat lungs . Lipids , 14 : 634
   PubMedGoogle Scholar
• Roehm , J. N. , Hadley , J. G. and Menzel , D. B. 1972 . The influence of vitamin ? on the lung fatty acids of rats exposed to ozone . Arch. Environ. Health , 24 : 237
   PubMed Web of Science ®Google Scholar
• Fletcher , B. L. and Tappel , A. L. 1973 . Protective effects of dietary α‐tocopherol in rats exposed to toxic levels of ozone and nitrogen dioxide. . Environ. Res. , 6 : 165
   PubMed Web of Science ®Google Scholar
• Csallany , A. S. and Ayaz , K. L. 1978 . The effects of intermittent nitrogen dioxide exposure on vitamin ?‐deficient and sufficient rats . Toxicol. Lett. , 2 : 97
   Web of Science ®Google Scholar
• Seranian , A. , Hacker , A. D. and Elsayed , N. 1982 . Influence of vitamin ? and nitrogen dioxide on lipid peroxidation in rat lung and liver microsomes . Lipids , 17 : 269
   PubMedGoogle Scholar
• Sevanian , A. , Elsayed , N. and Hacker , A. D. 1982 . Effect of vitamin ? deficiency and nitrogen dioxide exposure on lung lipid peroxidation, use of lipid epoxides and malonaldehyde as measures of peroxidation . J. Toxicol. Environ. Health , 10 : 743
   PubMed Web of Science ®Google Scholar
• Sagai , M. , Ichinose , T. , Oda , H. and Kubota , A. 1982 . Studies on biochemical effects of nitrogen dioxide. II. Changes of the protective systems in rat lungs and of lipid peroxidation by acute exposure . J. Toxicol. Environ. Health , 9 : 153
   PubMed Web of Science ®Google Scholar
• Church , D. F. and Pryor , W. A. 1985 . Free‐radical chemistry of cigarette smoke and its toxicological implications . Environ. Health Perspect. , 64 : 111
   PubMed Web of Science ®Google Scholar
• Bluhm , A. L. , Weinstein , J. and Sousa , J. A. 1971 . Free radicals in tobacco smoke . Nature (London) , 229 : 500
   PubMed Web of Science ®Google Scholar
• Pryor , W. A. , Tamura , M. and Church , D. F. 1984 . An ESR spin trapping study of the radicals produced in NOx/olefin reactions: a mechanism for the production of the apparently long‐lived radicals in gas‐phase cigarette smoke . J. Am. Chem. Soc. , 106 : 5073
   Web of Science ®Google Scholar
• Niki , E. , Minamisawa , S. , Oikawa , M. and Komuro , E. 1992 . Membrane damage from lipid oxidation induced by free radicals and cigarette smoke . Ann. N.Y. Acad. Sci. , 686 : 29
   Google Scholar
• Maeda , N. , Imaizumi , K. , Kon , K. and Shiga , T. 1987 . Kinetic study on functional impairment of nitric oxide‐exposed rat erythrocytes . Environ. Health Perspect. , 73 : 171
   PubMed Web of Science ®Google Scholar
• Pryor , W. A. and Stone , K. 1992 . Oxidants in cigarette smoke . Ann. N.Y. Acad. Sci. , 686 : 12
   Google Scholar
• Chow , K. C. 1982 . Dietary vitamin E and cellular susceptibility to cigarette smoking . Ann. N.Y. Acad. Sci. , 393 : 426
   PubMed Web of Science ®Google Scholar
• Retcofsky , H. L. 1982 . Magnetic resonance studies of coal . Coal Sci. , 1 : 43
   Google Scholar
• Dalai , N. S. , Jafari , B. , Petersen , M. , Green , F. H. Y. and Vallyathan , V. 1991 . Presence of stable coal radicals in autopsied coal miners’ lungs and its possible correlation to coal workers’ pneumoconiosis . Arch. Environ. Health , 46 : 366
   PubMedGoogle Scholar
• Pryor , W.A. , Nuggehalli , S.K. , Scherer , K.V. and Church , D. F. 1990 . An electron spin resonance study of the particles produced in the pyrolysis of perfluoro polymers . Chem. Res. Toxicol. , 3 : 2
   PubMed Web of Science ®Google Scholar
• Ohta , Y. , Shiraishi , H. and Takata , Y. 1985 . An electron spin resonance study of free radicals in black dust deposited in human lungs. . Arch. Environ. Health , 40 : 279
   PubMed Web of Science ®Google Scholar
• Farrington , J. A. , Ebert , M. , Land , E. J. and Fletcher , K. 1973 . Bipyridylium quaternary salts and related compounds. V. Pulse radiolysis studies of the reaction of paraquat radical with oxygen. Implications for the mode of action of bipyridyl herbicides . Biochim. Biophys. Acta , 314 : 372
   PubMed Web of Science ®Google Scholar
• Burk , R. F. , Lawrence , R. F. and Lane , J. M. 1980 . Liver necrosis and lipid peroxidation in the rat as the result of paraquat and diquat administration. Effect of selenium deficiency . J. Clin. Invest. , 65 : 1024
   PubMed Web of Science ®Google Scholar
• Smith , C. V. 1987 . Evidence for participation of lipid peroxidation and iron in diquat‐induced hepatic necrosis in vivo . Mol. Pharmacol. , 32 : 417
   PubMed Web of Science ®Google Scholar
• Smith , C. V. , Hughes , H. , Lauterburg , B. H. and Mitchell , J. R. 1985 . Oxidant stress and hepatic necrosis in rats treated with diquat . J. Pharmacol. Exp. Ther. , 235 : 172
   PubMed Web of Science ®Google Scholar
• Pryor , W. A. , Stanley , J. P. , Blair , E. and Cullen , G. B. 1976 . Autoxidation of polyunsaturated fatty acids. I. Effect of ozone on the autoxidation of neat methyl linoleate and methyl linolenate . Arch. Environ. Health , 31 : 201
   PubMed Web of Science ®Google Scholar
• Ewing , J. W. , Cosgrove , J. P. , Giamalva , D. H. , Church , D. F. and Pryor , W. A. 1989 . Autoxidation of methyl linoleate initiated by the ozonide of allylbenzene . Lipids , 24 : 609
   PubMed Web of Science ®Google Scholar
• Pryor , W. A. , Prier , D. G. and Church , D. F. 1981 . Radical products from the interaction of ozone and PUFA as demonstrated by electron spin resonance spin‐trapping technique . Environ. Res. , 24 : 42
   PubMed Web of Science ®Google Scholar
• Kennedy , C. H. , Hatch , G. E. , Slade , R. and Mason , R. P. 1991 . “ The detection of radicals produced in vivo during inhalation exposure to ozone: use of various spin traps ” . In Oxidative Damage and Repair , Edited by: Davies , K. J. A. 528 New York : Pergamon Press .
   Google Scholar
• Chow , C. K. , Plopper , C. G. , Chiu , M. and Dungworth , D. L. 1981 . Dietary vitamin E and pulmonary biochemical and morphological alterations of rats exposed to 0.1 ppm ozone . Environ. Res. , 24 : 315
   Web of Science ®Google Scholar
• Hu , P. C. , Miller , F. J. , Daniels , M. J. , Hatch , G. E. , Graham , J. A. , Gardner , D. E. and Selgrade , M. K. 1982 . Protein accumulation in lung lavage fluid following ozone exposure . Environ. Res. , 29 : 377
   PubMed Web of Science ®Google Scholar
• Dumelin , E. E. , Dillard , C. J. and Tappel , A. L. 1978 . Effect of vitamin E and ozone on pentane and ethane expired by rats . Arch. Environ. Health , 33 : 129
   PubMed Web of Science ®Google Scholar
• Pryor , W. A. and Church , D. F. 1991 . “ The reaction of ozone with unsaturated fatty acids, Aldehydes and hydrogen peroxide as mediators of ozone toxicity ” . In Oxidative Damage and Repair , Edited by: Davies , K. J. A. 496 New York : Pergamon Press .
   Google Scholar
• Videla , L. A. , Fernandez , B. , Ugarte , G. and Valenzuela , A. 1980 . Effect of acute ethanol intoxication on the content of reduced glutathione of the liver in relationship to its lipoperoxidative capacity in the rat . FEBS Lett. , 111 : 6
   PubMed Web of Science ®Google Scholar
• Kawase , T. , Kato , S. and Lieber , C. S. 1989 . Lipid peroxidation and antioxidant defense systems in rat liver after chronic ethanol feeding . Hepatology , 10 : 815
   PubMed Web of Science ®Google Scholar
• Valenzuela , A. , Fernandez , N. , Fernandez , V. , Ugarte , G. , Videla , L. A. , Guerra , R. and Villanueva , A. 1980 . Effect of acute ethanol ingestion on lipoperoxidation and on the activity of the enzymes related to peroxide metabolism in rat liver . FEBS Lett. , 111 : 11
   PubMed Web of Science ®Google Scholar
• Papatheofanis , F. J. and Lands , W. E. M. 1984 . Overestimation of lipid peroxidation during injury to liver by ethanol . Hepatology , 4 : 1025
   Google Scholar
• Inomata , T. , Rao , G. A. and Tsukamoto , H. 1987 . Lack of evidence for increased lipid peroxidation in ethanol‐induced centrilobular necrosis of rat liver . Liver , 7 : 233
   PubMedGoogle Scholar
• Porta , E. A. , Hartroft , W. S. and de la Iglesia , F. A. 1965 . Hepatic changes associated with chronic alcoholism in rats. . Lab. Invest. , 14 : 1437
   PubMedGoogle Scholar
• Bunyan , J. , Cawthorne , M. A. , Diplock , A. T. and Green , J. 1969 . Vitamin E and hepatotoxic agents. Lipid peroxidation and poisoning with orotic acid, ethanol and thioacetamide in rats . Br. J. Nutr. , 23 : 309
   PubMed Web of Science ®Google Scholar
• Videla , L. A. , Iturriaga , H. , Pino , M. E. and Bunout , D. 1982 . Content of hepatic reduced glutathione in chronic alcohol patients, influence of the lenght of abstinence and liver necrosis . Clin. Sci. , 66 : 283
   Google Scholar
• Shaw , S. , Rubin , K. P. and Lieber , C. S. 1983 . Depressed hepatic glutathione and increased diene conjugates in alcohol liver disease . Dig. Dis. Sci. , 28 : 585
   PubMed Web of Science ®Google Scholar
• Vendemiale , G. , Jayatillede , E. , Shaw , S. and Lieber , C. S. 1984 . Depression of biliary glutathione excretion by chronic ethanol feeding in the rat . Life Sci. , 34 : 1065
   PubMed Web of Science ®Google Scholar
• Dicker , E. and Cederbaum , A. L. 1988 . Increased oxygen radical‐dependent inactivation of metabolic enzymes by liver microsomes after chronic ethanol consumption . FASEB J. , 2 : 2901
   PubMed Web of Science ®Google Scholar
• Litov , R. E. , Irving , D. H. , Downey , J. E. and Tapple , A. L. 1978 . Lipid peroxidation, a mechanism involved in acute ethanol toxicity as demonstrated by in vivo pentane production in the rat . Lipids , 13 : 305
   PubMed Web of Science ®Google Scholar
• Müller , A. and Sies , H. 1982 . Role of alcohol dehydrogenase activity and of acetaldehyde in ethanol induced pentane production by isolated perfused rat liver . Biochem. J. , 206 : 153
   PubMed Web of Science ®Google Scholar
• Frank , H. , Hintze , T. , Bimboes , D. and Reramer , H. 1980 . Monitoring lipid peroxidation by breath analysis, Endogenous hydrocarbons and their metabolic elimination . Toxicol. Appl. Pharmacol. , 56 : 337
   PubMed Web of Science ®Google Scholar
• Mufti , S. L. and Eskelson , C. D. 1991 . Alcohol‐related cancers may be inhibited by dietary vitamin E . Ann. N.Y. Acad. Sci. , 625 : 824
   PubMedGoogle Scholar
• Rouach , H. , Houze , P. , Orfanelli , M. T. , Gentil , M. , Bourdon , R. and Nordmann , R. 1990 . Effect of acute ethanol administration on the subcellular distrbution of iron in rat liver and cerebellum . Biochem. Pharmacol. , 39 : 1095
   PubMed Web of Science ®Google Scholar
• Reinke , L. A. , Lai , E. K. , DuBose , C. M. and McCay , P. B. 1987 . Reactive free radical generation in vivo in heart and liver of ethanol‐fed rats: correlation with radical formation in vitro . Proc. Nati. Acad. Sci., USA. , 84 : 9223
   PubMed Web of Science ®Google Scholar
• Bj⊘rneboe , G. A. , Bj⊘neboe , A. , Hagen , B. F. , M⊘rland , J. and Drevon , C. A. 1987 . Reduced hepatic α‐tocopherol content after long‐term administration of ethanol to rats . Biochim. Biophys. Acta , 918 : 236
   PubMedGoogle Scholar
• Klassen , C. D. and Plaa , G. L. 1969 . Comparison of the biochemical alterations elicited in livers from rats treated with carbon tetrachloride, chloroform, 1,1,2‐trichloroethane and 1,1,1‐trichloroethane Biochem . Pharmacol , 18 : 2019
   Google Scholar
• Uehleke , H. and Werner , Th. 1975 . A comparative study on the irreversible binding of labeled halothane trichlorofluoromethane, chloroform, and carbon tetrachloride to hepatic protein and lipids in vitro and in vivo . Arch. Toxicol. , 34 : 289
   PubMed Web of Science ®Google Scholar
• Butler , T. 1961 . Reduction of carbon tetrachloride in vivo and reduction of carbon tetrachloride and chloroform in vitro by tissues and tissue constituents . J. Pharmacol. Exp. Ther. , 134 : 311
   PubMed Web of Science ®Google Scholar
• Castro , J. A. and Gomez , M. I. D. 1972 . Studies on the irreversible binding of 14C‐CCl4 to microsomal lipids in rats under varying experimental conditions . Toxicol. Appl. Pharmacol. , 23 : 541
   PubMed Web of Science ®Google Scholar
• Trudell , J. R. , Bösterling , B. and Trevor , A. J. 1982 . Reductive metabolism of carbon tetrachloride by human cytochromes P‐450 reconstituted in phospholipid vesicles: mass spectral identification of trichloromethyl radical bound to dioleoyl phosphatidylcholine . Proc. Natl. Acad. Sci., USA. , 79 : 2678
   PubMed Web of Science ®Google Scholar
• Reynolds , E. 1967 . Liver parenchymal cell injury. IV. Pattern of incorporation of carbon and chlorine from carbon tetrachloride into chemical constituents of liver in vivo . J. Pharmacol. Exp. Ther. , 155 : 117
   PubMed Web of Science ®Google Scholar
• Recknagel , R. O. and Glende , E. A. 1973 . Carbon tetrachloride hepatotoxicity, an example of lethal cleavage . CRC Critical Rev. Toxicol. , 2 : 263
   PubMedGoogle Scholar
• Younes , M. and Siegers , C. P. 1985 . The role of iron in the paracetamol‐ and CCl4‐induced lipid peroxidation and hepatotoxicity . Chem. Biol. Interact. , 55 : 327
   PubMed Web of Science ®Google Scholar
• Ansari , G. A. S. , Moslen , M. T. and Reynolds , E. S. 1982 . Evidence for in vivo covalent binding of CCl3 derived from CCl4 to cholesterol of rat liver . Biochem. Pharmacol. , 31 : 3509
   PubMed Web of Science ®Google Scholar
• Smith , C. V. , Hughes , H. and Mitchell , J. R. 1984 . Free radicals in vivo. Covalent binding to lipids . Mol. Pharmacol. , 26 : 112
   PubMed Web of Science ®Google Scholar
• Frank , H. , Thiel , D. and Macleod , J. 1989 . Mass spectrometric detection of cross‐linked fatty acids formed during radical‐induced lesion of lipid membranes . Biochem. J. , 260 : 873
   PubMed Web of Science ®Google Scholar
• Tomasi , A. , Albano , E. , Lott , K. A. K. and Slater , T. F. 1980 . Spin trapping of free radical products of carbon tetrachloride activation using pulse radiolysis and high energy radiation procedures . FEBS Lett. , 122 : 303
   PubMedGoogle Scholar
• Poyer , J. L. , McCay , P. B. , Lai , E. K. , Ganzen , E. G. and Davis , E. R. 1980 . Confirmation of assignment of the trichloromethyl radical spin adduct detected by spin trapping during 13C‐carbon tetrachloride metabolism in vitro and in vivo . Biochem. Biophys. Res. Commun. , 94 : 1154
   PubMed Web of Science ®Google Scholar
• Cheeseman , K. H. , Albano , E. F. , Tomasi , A. and Slater , T. F. 1985 . Biochemical studies on the metabolic activation of halogenated alkanes . Environ. Health Perspect. , 64 : 85
   PubMed Web of Science ®Google Scholar
• Janzen , E. G. , Stronks , H. J. , Dubose , C. M. , Poyer , J. L. and McCay , P. B. 1985 . Chemistry and biology of spin‐trapping radicals associated with halocarbon metabolism in vitro and in vivo . Environ. Health Perspect. , 64 : 151
   PubMed Web of Science ®Google Scholar
• Hughes , H. , Smith , C. V. , Horning , E. C. and Mitchell , J. R. 1983 . High‐performance liquid chromatography and gas chromatography‐mass spectrometry determination of specific lipid peroxidation products in vivo . Anal. Biochem. , 130 : 431
   PubMed Web of Science ®Google Scholar
• Hughes , H. , Smith , C. V. , Tsokos‐Kuhn , J. O. and Mitchell , J. R. 1986 . Quantitation of lipid peroxidation products by gas chromatography‐mass spectrometry . Anal. Biochem. , 152 : 107
   PubMedGoogle Scholar
• Morrow , J. D. , Awad , J. A. , Boss , H. J. , Blair , L A. and Roberts , L. J. 1992 . Non‐cyclooxygenase‐derivedprostanoids (F2‐isoprostanes) are formed in situ on phospholipids . Proc. Nad. Acad. Sci. USA. , 89 : 10721
   PubMed Web of Science ®Google Scholar
• Hashimoto , S and Recknagel , R. O. 1968 . No chemical evidence of hepatic lipid peroxidation in acute ethanol toxicity . 8 : 225
   Google Scholar
• Cawthorne , M. A. , Bun van , J. , Sennitt , M. V. and Green , J. 1970 . Vitamin E and hepatotoxic agents, III. Vitamin E, synthetic antioxidants and carbon tetrachloride toxicity in the rat . Br. J. Nutr. , 24 : 357
   PubMed Web of Science ®Google Scholar
• McLean , A. E. M. 1967 . The effect of diet and vitamin E on liver injury due to carbon tetrachloride . Br. J. Exp. Pathol. , 48 : 632
   PubMedGoogle Scholar
• Corongiu , F. P. , Poli , G. , Dianzani , M. U. , Cheeseman , K. H. and Slater , T. F. 1986 . Lipid peroxidation and molecular damage to poryunsaturated fatty acids in rat liver. Recognition of two classes of hydroperoxides formed under conditions in vivo . Chem.‐Biol. Interact. , 59 : 147
   PubMed Web of Science ®Google Scholar
• Gallagher , C. H. 1962 . The effect of antioxidants on poisoning by carbon tetrachloride . Aust. J. Exp. Biol. Med. Sci. , 40 : 241
   PubMedGoogle Scholar
• Hove , E. L. 1948 . Interrelation between α‐tocopherol and protein metabolism. III. The protective effect of vitamin E and certain nitrogenous compounds against CCl4 poisoning in rats . Arch Biochem. , 17 : 467
   PubMedGoogle Scholar
• De Groot , H. and Noll , T. 1987 . The role of physiologic oxygen partial pressures in lipid peroxidation. Theoretical considerations and experimental evidence . Chem. Phys. Lipids , 44 : 209
   PubMed Web of Science ®Google Scholar
• White , R. E. and Coon , M. J. 1980 . Oxygen activation by cytochrome P‐450 . Ann. Rev. Biochem. , 49 : 315
   PubMed Web of Science ®Google Scholar
• Marnett , L. J. 1990 . Prostaglandin synthase‐mediated metabolism of carcinogens and a potential role for peroxyl radicals as reactive intermediates . Environ. Health Perspect. , 88 : 5
   PubMedGoogle Scholar
• Hebbel , R. P. , Morgan , W. T. , Eaton , J. W. and Hedlund , B. E. 1988 . Accelerated autoxidation and heme loss due to instability of sickle hemoglobin . Proc. Nati. Acad. Sci. USA. , 85 : 237
   PubMed Web of Science ®Google Scholar
• Hafez , M. , Amar , E. , Zedan , M. , Hammand , H. , Sorour , A. H. , El‐Desouky , E. A. and Gamil , N. 1986 . Improved eryth‐rocyte survival with combined vitamin E and selenium therapy in children with glucose‐6‐phosphate dehydrogenase deficiency and mild chronic hemolysis . J. Pediatrics , 108 : 558
   PubMedGoogle Scholar
• Sadrzadeh , S. M. H. , Graf , E. , Panter , S. S. , Hallaway , P. E. and Eaton , J. W. 1984 . Hemoglobin. A biologic Fenton reagent . J. Biol. Chem. , 259 : 14354
   PubMed Web of Science ®Google Scholar
• Mieyal , J. J. , Ackerman , R. S. , Blumer , J. L. and Freeman , L. S. 1976 . Characterization of enzyme‐like activity of human hemoglobin. Properties of the hemoglobin‐P‐450 re‐ductase‐coupled aniline hydroxylation system . J. Biol. Chem. , 251 : 3436
   PubMed Web of Science ®Google Scholar
• Puppo , A. and Halliwell , B. 1988 . Formation of hydroxyl radicals from hydrogen peroxide in the presence of iron . Biochem. J. , 249 : 185
   PubMed Web of Science ®Google Scholar
• Ortize de Montellano , P. R. and Catalano , C. E. 1985 . Epoxidation of styrene by hemoglobin and myoglobin. Transfer of oxidizing equivalents to the protein surface . J. Biol. Chem. , 260 : 9265
   PubMedGoogle Scholar
• Steffek , R. P. and Thomas , M. J. 1991 . Hydrogen peroxide modification of human oxyhemoglobin . Free Radical Res. Commun. , 12–13 : 489
   Google Scholar
• Davies , K. J. A. , Delsignore , M. E. and Lin , S. W. 1987 . Protein damage and degradation by oxygen radicals. IL Modification of amino acids . J. Biol. Chem. , 262 : 9902
   PubMed Web of Science ®Google Scholar
• Rosen , A.D. and Frumin , N. V. 1979 . Focal epileptogenesis after intracortical hemoglobin injection . Exp. Neuro. , 66 : 277
   PubMedGoogle Scholar
• Sadrzadeh , S. M. H. and Eaton , J. W. 1988 . Hemoglobin‐mediated oxidant damage to the central nervous system requires edogenous ascorbate . J. Clin. Invest. , 82 : 1510
   PubMed Web of Science ®Google Scholar
• Willmore , J. L. , Sypert , G. W. , Munson , J. B. and Hurd , R. W. 1978 . Chronic focal epileptiform discharges induced by injection of iron into rat and cat cortex . Science , 200 : 1501
   PubMed Web of Science ®Google Scholar
• Bolli , R. , Patel , B.S. , Jeroudi , M.O. , Lai , E.K. and McCay , P. B. 1988 . Demonstration of free radical generation in “stunned”; myocardium of intact dogs with the use of the spin trap α‐phenyl N‐tert‐butyl nitrone . J. Clin. Invest. , 82 : 476
   PubMed Web of Science ®Google Scholar
• Zweier , J. L. , Kuppusamy , P. , Williams , R. , Rayburn , B. K. , Smith , D. , Weisfeldt , M. L. and Flaherty , J. T. 1989 . Measurement and characterization of postischemic free radical generation in the isolated perfused heart . J. Biol. Chem. , 264 : 18890
   PubMed Web of Science ®Google Scholar
• Granger , D. N. , Rutili , G. and McCord , J. M. Superoxide radicals in feline intestinal ischemia . Gastroenteology , 81 22 1981
   PubMedGoogle Scholar
• Parks , D. A. , Bulkley , G. B. , Granger , D. N. , Hamilton , S. R. and McCord , J. M. 1982 . Ischemic injury in the cat small intestine, Role of Superoxide radicals . Gastroenterology , 82 : 9
   PubMed Web of Science ®Google Scholar
• Glavind , J. S. , Hartmann , S. , Clemmesen , J. , Jessen , K. E. and Dam , H. 1952 . Role of lipoperoxidases in human pathology, II. The presence of peroxidised lipids in the atherosclerotic aorta . Acta Pathol. Microbiol. Scand. , 30 : 1
   PubMedGoogle Scholar
• Harland , W. A. , Gilbert , J. D. , Steel , G. and Brooks , C. J. W. 1971 . Lipids of human atheroma. V . Atherosclerosis , 13 : 239
   PubMed Web of Science ®Google Scholar
• Brooks , C. J. W. , Steel , G. , Gilbert , J. D. and Harland , W. A. 1971 . Lipids of human atheroma, TV . Atherosclerosis , 13 : 223
   PubMed Web of Science ®Google Scholar
• Wang , T. and Powell , W. S. 1991 . Increased levels of monohydroxy metabolites of arachidonic acid and linoleic acid in LDL and aorta from atherosclerotic rabbits . Biochim. Biophys. Acta , 1084 : 129
   PubMed Web of Science ®Google Scholar
• Fowler , S. , Shio , H. and Haley , N. J. 1979 . Characterization of lipid‐laden aortic cells from cholesterol‐fed rabbits. IV . Lab. Invest. , 41 : 372
   PubMed Web of Science ®Google Scholar
• Mahley , R. W. , Innerarity , T. L. , Weisgraber , K. B. and Ob , S. Y. 1979 . Altered metabolism of plasma lipoproteins after selective chemical modification of lysine residues of the apoproteins . J. Clin. Invest. , 64 : 743
   PubMed Web of Science ®Google Scholar
• Fogelman , A. M. , Shechter , I. , Seager , J. , Hokom , M. , Child , J. S. and Edwards , P. A. 1980 . Malondialdehyde alteration of low density lipoprotein leads to cholesteryl ester accumulation in human monocyte‐macrophages . Proc. Nati. Acad. Sci. USA. , 77 : 2214
   PubMed Web of Science ®Google Scholar
• Witztum , J. L. and Steinberg , D. 1991 . Role of oxidized low density lipoprotein in atherogenesis . J. Clin. Invest. , 88 : 1785
   PubMed Web of Science ®Google Scholar
• Fong , L. G. , Fong , T. A. T. and Cooper , A. D. 1991 . Inhibition of lipopolysaccharide‐induced interleukin‐1b mRNA expression in mouse macrophages by oxidized low density lipoprotein . J. Upid Res. , 32 : 1899
   PubMed Web of Science ®Google Scholar
• Lougheed , Zhang , H. and Steinbrecher , U. P. 1991 . Oxidized low density lipoprotein is resistant to cathepsins and accumulates within macrophages . J. Biol. Chem. , 266 : 14519
   PubMed Web of Science ®Google Scholar
• Palinski , W. , Rosenfeld , M. E. , Herttuala , S. Y. , Gurtner , G. C. , Socher , S. S. , Butler , S. W. , Partha , S. , Carew , T. E. , Steinberg , D. and Witztum , J. L. 1989 . Low density lipoprotein undergoes oxidative modification in vivo . Proc. Natl Acad. Sci. USA. , 86 : 1372
   PubMed Web of Science ®Google Scholar
• Henriksen , T. , Mahoney , E.M. and Steinberg , D. 1981 . Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells . Proc. Natl. Acad. Sci. USA. , 78 : 6499
   PubMed Web of Science ®Google Scholar
• Henriksen , T. , Mahoney , E. M. and Steinberg , D. 1983 . Enhanced macrophage degradation of biologically modified low density lipoprotein. . Arteriosclerosis , 3 : 149
   PubMedGoogle Scholar
• Hiramatsu , K. , Rosen , H. , Heinecke , J. W. , Wolfbauer , G. and Chait , A. 1987 . Superoxide initiates oxidation of low density lipoprotein by human monocytes . Arteriosclerosis , 7 : 55
   PubMedGoogle Scholar
• Rankin , S. M. , Parthasarathy , S. and Steinberg , D. 1991 . Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages . J. Upid Res. , 32 : 449
   PubMed Web of Science ®Google Scholar
• Parthasarathy , S. , Wieland , E. and Steinberg , D. 1989 . A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein . Proc. Nati. Acad. Sci. USA. , 86 : 1046
   PubMed Web of Science ®Google Scholar
• Yla‐Herttuala , S. Y. , Palinski , W. , Rosenfeld , M.E. , Steinberg , D. and Witztum , J. L. 1989 . Gene expression in macrophage‐rich human atherosclerotic lesions . J. Clin. Invest. , 84 : 1086
   PubMed Web of Science ®Google Scholar
• Steinbrecher , U. P. , Parthasarathy , S. , Leake , D. S. , Witztum , J. L. and Steinberg , D. 1984 . Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids . Proc. Natl. Acad. Sci. USA. , 81 : 3883
   PubMed Web of Science ®Google Scholar
• Lenz , M.I. , Hughes , H. , Mitchell , J.R. , Via , D.P. , Guyton , J. R. , Taylor , A. A. , Gotto , A. M. and Smith , C. V. 1990 . Lipid hydroperoxy and hydroxy derivatives in copper‐catalyzed oxidation of low density lipoprotein . J. Lipid Res. , 31 : 1043
   PubMed Web of Science ®Google Scholar
• Heinecki , J. W. , Rosen , H. and Chait , A. 1984 . Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture . J. Clin. Invest. , 74 : 1890
   PubMedGoogle Scholar
• Wang , T. , Yu , W‐G. and Powell , W. S. 1992 . Formation of monohydroxy derivatives of arachidonic acid, linoleic acid, and oleic acid during oxidation of low density lipoprotein by copper ions and endothelial cells . J. Lipid Res. , 33 : 525
   PubMed Web of Science ®Google Scholar
• Esterbauer , H. , Jurgens , G. , Quehenberger , O. and Koller , E. 1987 . Autoxidation of human low density lipoprotein, loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes . J. Lipid Res. , 28 : 495
   PubMed Web of Science ®Google Scholar
• Parthasarathy , S. , Young , S. G. , Witztum , J. L. , Pittman , R. C. and Steinberg , D. 1986 . Probucol inhibits oxidative modification of low density lipoprotein . J. Clin. Invest. , 77 : 641
   PubMed Web of Science ®Google Scholar
• Morel , D. W. , DiCorleto , P. E. and Chisolm , G. M. 1984 . Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation . Arteriosclerosis , 4 : 357
   PubMedGoogle Scholar
• Dieber‐Rotheneder , M. , Puhl , H. , Waeg , G. , Striegl , G. and Esterbauer , H. 1991 . Effect of oral supplementation with D‐α‐tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidation . J. Lipid Res. , 32 : 1325
   PubMed Web of Science ®Google Scholar
• Thomas , C. E. and Jackson , R. L. 1991 . Lipid hydroperoxide involvement in copper‐dependent and independent oxidation of low density lipoproteins . J. Pharmacol. Exp. Ther. , 256 : 1182
   PubMed Web of Science ®Google Scholar
• Shimano , H. , Yamada , N. , Ishibarki , S. , Morkuno , H. , Mori , N. , Gotoda , T. , Akanuma , Y. , Murase , T. , Yazaki , Y. and Fumimaro , T. 1991 . Oxidation‐labile subfraction of human plasma low density lipoprotein isolated by ion‐exchange chromatogtaphy . J. Lipid Res. , 32 : 763
   PubMed Web of Science ®Google Scholar
• Steinbrecher , U. P. 1987 . Oxidation of human low density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxide decomposition products . J. Biol. Chem. , 262 : 3603
   PubMed Web of Science ®Google Scholar
• Stadtman , E. R. and Oliver , C. N. 1991 . Metal‐catalyzed oxidation of proteins . J. Biol. Chem. , 266 : 2005
   PubMed Web of Science ®Google Scholar
• Dousset , N. , Negre‐Salvayre , A. , Lopez , M. , Salvayre , R. and Douste‐Blazy , L. 1990 . Ultraviolet‐treated lipoproteins as a model system for the study of the biological effect of lipid peroxides on cultured cells. I . Biochim. Biophys. Acta , 1045 : 219
   PubMed Web of Science ®Google Scholar
• Cathcart , M. K. , Morel , D. W. and Chisolm , G. M. 1985 . Monocytes and neutrophils oxidize low density lipoproteins making it cytotoxic . J. Leukocyte Biol. , 38 : 341
   PubMed Web of Science ®Google Scholar
• Negre‐Salvayre , A. , Lopez , M. , Levade , T. , Pieraggi , M. T. , Dousset , N. , Douste‐Blazy , L. and Salvayre , R. 1990 . Ultraviolet‐treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cells. II . Biochim. Biophys. Acta , 1045 : 224
   PubMedGoogle Scholar
• Morel , D. W. , Hessler , J. R. and Chisolm , G. M. 1983 . Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid . J. Lipid Res. , 24 : 1070
   PubMed Web of Science ®Google Scholar
• Steinberg , D. , Parthasarathy , S. , Carew , T.E. , Khoo , J. C. and Witztum , J. L. 1989 . Beyond cholesterol . NEJM , 320 : 915
   PubMed Web of Science ®Google Scholar
• Quinn , M. T. , Parthasarathy , S. , Fong , L. G. and Steinberg , D. 1987 . Oxidadvely modified low density lipoproteins, a potential role in recruitment and retention of mono‐cyte/macrophages during atherogenesis . Proc. Natl. Acad. Sci. USA. , 84 : 2995
   PubMed Web of Science ®Google Scholar
• Hessler , J. R. , Robertson , A. L. and Chisolm , G. M. 1979 . LDL‐induced cytotoxicity and its inhibition by HDL in human vascular smooth muscle and endothelial cells in culture . Atherosclerosis , 32 : 213
   PubMed Web of Science ®Google Scholar
• Haberland , M. E. , Fong , D. and Cheng , L. 1988 . Malondialdehyde‐altered protein occurs in atheroma of Watanabe hyperlipidemic rabbits. . Science , 241 : 215
   PubMed Web of Science ®Google Scholar
• Esterbauer , H. , Gebicki , J. , Puhl , H. and Jürgens , G. 1992 . The role of lipid peroxidation and antioxidants in oxidative modification of LDL . Free Radical Biol. Med. , 13 : 341
   PubMed Web of Science ®Google Scholar
• Esterbauer , H. , Striegl , G. , Puhl , H. and Rotheneder , M. 1989 . Continuous monitoring of in vitro oxidation of human low density lipoprotein . Free Rad. Res. Commun. , 6 : 67
   PubMed Web of Science ®Google Scholar