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Review Article

Recent advances on topical antimicrobials for skin and soft tissue infections and their safety concerns

, , , , , & ORCID Icon show all
Pages 40-78 | Received 05 Sep 2015, Accepted 25 Mar 2017, Published online: 19 Apr 2017

References

  • Abelson MB, Heller W, Shapiro AM, Si E, Hsu P, Bowman LM; AzaSite Clinical Study Group. 2008. Clinical cure of bacterial conjunctivitis with azithromycin 1%: vehicle-controlled, double-masked clinical trial. Am J Ophthalmol. 145:959–965.
  • Abushahba MFN, Mohammad H, Seleem MN. 2016. Targeting multidrug-resistant staphylococci with an anti-rpoA peptide nucleic acid conjugated to the HIV-1 TAT cell penetrating peptide. Mol Ther Nucleic Acids. 5:e339.
  • Abuzaid A, Hamouda A, Amyes SG. 2012. Klebsiella pneumoniae susceptibility to biocides and its association with cepA, qacΔE and qacE efflux pump genes and antibiotic resistance. J Hosp Infect. 81:87–91.
  • Ahmad A, Khan A, Manzoor N, Khan LA. 2010. Evolution of ergosterol biosynthesis inhibitors as fungicidal against Candida. Microb Pathog. 48:35–41.
  • Ahmadi B, Mirhendi H, Shidfar MR, Nouripour-Sisakht S, Jalalizand N, Geramishoar M, Shokoohi GR. 2015. A comparative study on morphological versus molecular identification of dermatophyte isolates. J Med Mycol. 25:29–35.
  • Ahmed SA, Abbas MA, Jouvion G, Al-Hatmi AM, de Hoog GS, Kolecka A, Mahgoub el S. 2015. Seventeen years of subcutaneous infection by Aspergillus flavus; eumycetoma confirmed by immunohistochemistry. Mycoses. 58:728–734.
  • Alastruey-Izquierdo A, Mellado E, Peláez T, Pemán J, Zapico S, Alvarez M, Rodríguez-Tudela JL, Cuenca-Estrella M; FILPOP Study Group. 2013. Population-based survey of Filamentous Fungi and Antifungal Resistance in Spain (FILPOP Study). Antimicrob Agents Chemother. 57:3380–3387.
  • Alavi A, Sibbald RG, Ladizinski B, Saraiya A, Lee KC, Skotnicki-Grant S, Maibach H. 2016. Wound-related allergic/irritant contact dermatitis. Adv Skin Wound Care. 29:278–286.
  • Al-Mehna BMM, Kadhum EAH. 2011. Effect of Lawsonia inermis extract on the pathological changes of skin infection by Streptococcus pyogenes in lab mice. AL-Qadisiya J Vet Med Sci. 10:45–54.
  • Alphonsa BM, Kumar PTS, Praveen G, Biswas R, Chennazhi KP, Jayakumar R. 2013. Antimicrobial drugs encapsulated in fibrin nanoparticles for treating microbial infested wounds. Pharm Res. 31:1254.
  • Alves DR, Gaudion A, Bean JE, Biswas R, Chennazhi KP, Jayakumar R. 2014. Combined use of bacteriophage K and a novel bacteriophage to reduce Staphylococcus aureus biofilm formation. Appl Environ Microbiol. 80:6694–6703.
  • Andonova M, Urumova V. 2013. Immune surveillance mechanisms of the skin against the stealth infection strategy of Pseudomonas aeruginosa—review. Comp Immunol Microbiol Infect Dis. 36:433–448.
  • Anjum S, Gupta A, Sharma D, Gautam D, Bhan S, Sharma A, Kapil A, Gupta B. 2016. Development of novel wound care systems based on nanosilver nanohydrogels of polymethacrylic acid with Aloe vera and curcumin. Mater Sci Eng C Mater Biol Appl. 64:157–166.
  • Ansari S, Hedayati MT, Zomorodian K, Pakshir K, Badali H, Rafiei A, Ravandeh M, Seyedmousavi S. 2016. Molecular characterization and in vitro antifungal susceptibility of 316 clinical isolates of dermatophytes in Iran. Mycopathologia. 181:89–95.
  • Atalay A, Koc AN, Suel A, Sav H, Demir G, Elmali F, Cakir N, Seyedmousavi S. 2016. Conventional morphology versus PCR sequencing, rep-PCR, and MALDI-TOF-MS for identification of clinical aspergillus isolates collected over a 2-year period in a University Hospital at Kayseri, Turkey. J Clin Lab Anal. 30:745–750.
  • Avitabile C, Netti F, Orefice G, Palmieri M, Nocerino N, Malgieri G, D'Andrea LD, Capparelli R, Fattorusso R, Romanelli A. 2013. Design, structural and functional characterization of a Temporin-1b analog active against Gram-negative bacteria. Biochim Biophys Acta. 1830:3767–3775.
  • Awouafack MD, McGaw LJ, Gottfried S, Mbouangouere R, Tane P, Spiteller M, Eloff JN. 2013. Antimicrobial activity and cytotoxicity of the ethanol extract, fractions and eight compounds isolated from Eriosema robustum (Fabaceae). BMC Complement Altern Med. 13:289.
  • Azadpour M, Rezaei M, Taati M, Dehnoo MG, Ezatpour B. 2014. Antioxidant, antibacterial, and wound-healing properties of methanolic extract of Pistacia khinjuk. Comp Clin Path. 24:1908.
  • Bai H, You Y, Yan H, Meng J, Xue X, Hou Z, Zhou Y, Ma X, Sang G, Luo X. 2012. Antisense inhibition of gene expression and growth in gram-negative bacteria by cell-penetrating peptide conjugates of peptide nucleic acids targeted to rpoD gene. Biomaterials. 33:659–667.
  • Beltrán-Alzate C, López Díaz F, Romero-Montoya M, Sakamuri R, Li W, Kimura M, Brennan P, Cardona-Castro N. 2016. Leprosy drug resistance surveillance in Colombia: the experience of a sentinel country. PLoS Negl Trop Dis. 10:e0005041.
  • Bennett JW, Robertson JL, Hospenthal DR, Wolf SE, Chung KK, Mende K, Murray CK. 2010. Impact of extended spectrum beta-lactamase producing Klebsiella pneumoniae infections in severely burned patients. J Am Coll Surg. 211:391–399.
  • Bernardeschi C, Foulet F, Ingen-Housz-Oro S, Ortonne N, Sitbon K, Quereux G, Lortholary O, Chosidow O, Bretagne S; French Mycosis Study Group. 2015. Cutaneous invasive Aspergillosis: retrospective Multicenter Study of the French Invasive-Aspergillosis Registry and Literature Review. Medicine (Baltimore). 94:e1018.
  • Bezzerri V, Avitabile C, Dechecchi MC, Lampronti I, Borgatti M, Montagner G, Cabrini G, Gambari R, Romanelli A. 2014. Antibacterial and anti-inflammatory activity of a temporin B peptide analogue on an in vitro model of cystic fibrosis. J Pept Sci. 20:822–830.
  • Bogavac M, Karaman M, Janjušević L, Sudji J, Radovanović B, Novaković Z, Simeunović J, Božin B. 2015. Alternative treatment of vaginal infections – in vitro antimicrobial and toxic effects of Coriandrum sativum L. and Thymus vulgaris L. essential oils. J Appl Microbiol. 119:697–710.
  • Bonesso MF, Marques SA, Cunha MLRS. 2011. Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA): molecular background, virulence, and relevance for public health. J Venom Anim Toxins Incl Trop Dis. 17:378–386.
  • Boonkaew B, Barber PM, Rengpipat S, Supaphol P, Kempf M, He J, John VT, Cuttle L. 2014. Development and characterization of a novel, antimicrobial, sterile hydrogel dressing for burn wounds: single-step production with gamma irradiation creates silver nanoparticles and radical polymerization. J Pharm Sci. 103:3244–3253.
  • Brandolt TM, Klafke GB, Gonçalves CV, Bitencourt LR, Martinez AM, Mendes JF, Meireles MC, Xavier MO. 2017. Prevalence of Candida spp. in cervical-vaginal samples and the in vitro susceptibility of isolates. Braz J Microbiol. 48:145–150.
  • Brown GD, Denning DW, Gow NA, Levitz SM, Netea MG, White TC. 2012. Hidden killers: human fungal infections. Sci Transl Med. 4:165rv13.
  • Brustein VP, Souza-Araújo FV, Vaz AF, Araújo RV, Paiva PM, Coelho LC, Carneiro-Leão AM, Teixeira JA, Carneiro-da-Cunha MG, Correia MT. 2012. A novel antimicrobial lectin from Eugenia malaccensis that stimulates cutaneous healing in mice model. Inflammopharmacology. 20:315–322.
  • Cafarchia C, Iatta R, Latrofa MS, Gräser Y, Otranto D. 2013. Molecular epidemiology, phylogeny and evolution of dermatophytes. Infect Genet Evol. 20:336–351.
  • Cannon CL, Hogue LA, Vajravelu RK, Capps GH, Ibricevic A, Hindi KM, Kascatan-Nebioglu A, Walter MJ, Brody SL, Youngs WJ. 2009. In vitro and murine efficacy and toxicity studies of nebulized SCC1, a methylated caffeine–silver(I) complex, for treatment of pulmonary infections. Antimicrob Agents Chemother. 53:3285–3293.
  • Castanheira M, Griffin MA, Deshpande LM, Mendes RE, Jones RN, Flamm RK. 2016. Detection of mcr-1 among Escherichia coli clinical isolates collected worldwide as part of the SENTRY Antimicrobial Surveillance Program in 2014 and 2015. Antimicrob Agents Chemother. 60:5623–5624.
  • Chadha P, Katare OP, Chhibber S. 2016. In vivo efficacy of single phage versus phage cocktail in resolving burn wound infection in BALB/c mice. Microb Pathog. 99:68–77.
  • Chambers HF. 1997. Review Methicillin resistance in staphylococci: molecular and biochemical basis and clinical implications. Clin Microbiol Rev. 10:781–791.
  • Chaplin S, Kennedy C. 2008. Retapamulin (Altargo): novel antibacterial for impetigo. Prescriber. 19:12–15.
  • Chen J, Yi J, Liu L, Yin S, Chen R, Li M, Ye C, Zhang YQ, Lai W. 2010. Substrate adaptation of Trichophyton rubrum secreted endoproteases. Microb Pathog. 48:57–61.
  • Chen WC, Liou SS, Tzeng TF, Lee SL, Liu IM. 2012. Wound repair and anti-inflammatory potential of Lonicera japonica in excision wound-induced rats. BMC Complement Altern Med. 12:226.
  • Chen Y, Zhao J, Shan X, Han X, Tian S, Chen F, Su X, Sun Y, Huang L, Han L. 2017. A point-prevalence survey of healthcare-associated infections in 52 Chinese hospitals. J Hosp Infect. 95:105–111.
  • Chou YH, Lee MS, Lin RY, Wu CY. 2015. Risk factors for methicillin-resistant Staphylococcus aureus skin and soft-tissue infections in outpatients in Taiwan. Epidemiol Infect. 143:749–753.
  • Chowdhary A, Sharma C, Kathuria S, Hagen F, Meis JF. 2015. Prevalence and mechanism of triazole resistance in Aspergillus fumigatus in a referral chest hospital in Delhi, India and an update of the situation in Asia. Front Microbiol. 6:428.
  • Chung PY, Gambari R, Chen YX, Cheng CH, Bian ZX, Chan ASC, Tang JCO, Leung PHM, Chui CH, Lam KH. 2015. Development of 8-benzyloxy substituted quinoline ethers and evaluation of their antimicrobial activities. Med Chem Res. 24:1568–1577.
  • Çıralı DE, Uyar Z, Koyuncu İ, Hacıoğlu N. 2015. Synthesis, characterization and catalytic, cytotoxic and antimicrobial activities of two novel cyclotriphosphazene-based multisite ligands and their Ru(II) complexes. Appl Organomet Chem. 29:536–542.
  • Coleman DC. 2014. Molecular epidemiology, phylogeny and evolution of Candida albicans. Infect Genet Evol. 21:166–178.
  • Coman G, Zinsmeister C, Norris P. 2015. Occupational contact dermatitis: workers' compensation patch test results of Portland, Oregon, 2005–2014. Dermatitis. 26:276–283.
  • Critchley IA, Ochsner UA. 2008. Recent advances in the preclinical evaluation of the topical antibacterial agent REP8839. Curr Opin Chem Biol. 12:409–417.
  • Cundell AM. 2016. Microbial ecology of the human skin. Microb Ecol. doi:10.1007/s00248-016-0789-6.
  • Cunliffe WJ, Holland KT, Bojar R, Levy SF. 2002. A randomized, double-blind comparison of a clindamycin phosphate/benzoyl peroxide gel formulation and a matching clindamycin gel with respect to microbiologic activity and clinical efficacy in the topical treatment of acne vulgaris. Clin Ther. 24:1117–1133.
  • Czihal P, Knappe D, Fritsche S, Zahn M, Berthold N, Piantavigna S, Müller U, Van Dorpe S, Herth N, Binas A, et al. 2012. Api88 is a novel antibacterial designer peptide to treat systemic infections with multidrug-resistant Gram-negative pathogens. ACS Chem Biol. 7:1281–1291.
  • Datamonitor. 2011. Epidemiology: skin and Soft Tissue Infections – increasing, and increasingly dominated by S. aureus. Datamonitor Research Store. Available from: http://www.datamonitor.com/store/Product/epidemiology_skin_and_soft_tissue_infections_increasing_and_increasingly_dominated_by_s_aureus?productid=HC00181-002
  • Davies S, Guidry C, Politano A, Rosenberger L, McLeod M, Hranjec T, Sawyer R. 2014. Aspergillus infections in transplant and non-transplant surgical patients. Surg Infect (Larchmt). 15:207–212.
  • Dawson AL, Dellavalle RP, Elston DM. 2012. Infectious skin diseases: a review and needs assessment. Dermatol Clin. 30:141–151.
  • de Aquino PEA, Pereira NLF, Figueredo FG, Ferreira SS, Leandro LMG, Souza JCCO, de Morais Oliveira CD, Santana JKL, Torres CMG, et al. 2015. The association between drugs and herbal products: in vitro enhancement of the antibiotic activity by extracts of dry floral buttons of Egletes viscosa L. (macela). Eur J Integr Med. 7:258–262.
  • de Castro PA, Bom VL, Brown NA, de Almeida RS, Ramalho LN, Savoldi M, Goldman MH, Berretta AA, Goldman GH. 2013. Identification of the cell targets important for propolis-induced cell death in Candida albicans. Fungal Genet Biol. 60:74–86.
  • Digby SSW, Hald M, Arendrup MC, Hjort SV, Kofoed K. 2017. Darier disease complicated by terbinafine-resistant Trichophyton rubrum: a case report. Acta Derm Venereol. 97:139–140.
  • Dryden M, Goddard C, Madadi A, Heard M, Saeed K, Cooke J. 2014b. Using antimicrobial Surgihoney to prevent caesarean wound infection. Br J Midwif. 22:111–115.
  • Dryden M, Lockyer G, Saeed K, Cooke J. 2014a. Engineered honey: in vitro antimicrobial activity of a novel topical wound care treatment. JGAR. 2:168–172.
  • Dryden MS. 2009. Skin and soft tissue infection: microbiology and epidemiology. Int J Antimicrob Agents. 34:S2–S7.
  • Duc Q, Breetveld M, Middelkoop E, Scheper RJ, Ulrich MM, Gibbs S. 2007. A cytotoxic analysis of antiseptic medication on skin substitutes and autograft. Br J Dermatol. 157:33–40.
  • Duplantier AJ, van Hoek ML. 2013. The human cathelicidin antimicrobial peptide LL-37 as a potential treatment for polymicrobial infected wounds. Front Immunol. 4:143.
  • El-Gohary M, van Zuuren EJ, Fedorowicz Z, Burgess H, Doney L, Stuart B, Moore M, Little P. 2014. Topical antifungal treatments for tinea cruris and tinea corporis. Cochrane Database Syst Rev. 8:CD009992.
  • Ellis MW, Schlett CD, Millar EV, Crawford KB, Cui T, Lanier JB, Tribble DR. 2014. Prevalence of nasal colonization and strain concordance in patients with community-associated Staphylococcus aureus skin and soft-tissue infections. Infect Control Hosp Epidemiol. 35:1251–1256.
  • Enright MC, Robinson DA, Randle G, Feil EJ, Grundmann H, Spratt BG. 2002. The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA). Proc Natl Acad Sci USA. 99:7687–7692.
  • Esposito S, Bassetti M, Bonnet E, Bouza E, Chan M, De Simone G, Dryden M, Gould I, Lye DC, Saeed K, et al; International Society of Chemotherapy (ISC). 2016. Hot topics in the diagnosis and management of skin and soft-tissue infections. Int J Antimicrob Agents. 48:19–26.
  • Evans EGV, James IGV, Seaman RAJ, Richardson MD. 1993. Does naftifine have anti-inflammatory properties? A double-blind comparative study with 1% clotrimazole/1% hydrocortisone in clinically diagnosed fungal infection of the skin. Br J Dermatol. 129:437–442.
  • Fan NC, Chen HH, Chen CL, Ou LS, Lin TY, Tsai MH, Chiu CH. 2014. Rise of community-onset urinary tract infection caused by extended-spectrum β-lactamase-producing Escherichia coli in children. J Microbiol Immunol Infect. 47:399–405.
  • Faure-Cognet O, Fricker-Hidalgo H, Pelloux H, Leccia MT. 2016. Superficial Fungal Infections in a French Teaching Hospital in Grenoble Area: retrospective Study on 5470 samples from 2001 to 2011. Mycopathologia. 181:59.
  • Firinu D, Massidda O, Lorrai MM, Serusi L, Peralta M, Barca MP, Serra P, Manconi PE. 2011. Successful treatment of chronic mucocutaneous candidiasis caused by azole-resistant Candida albicans with posaconazole. Clin Dev Immunol. 2011:283239.
  • Fish R, Kutter E, Wheat G, Blasdel B, Kutateladze M, Kuhl S. 2016. Bacteriophage treatment of intransigent diabetic toe ulcers: a case series. J Wound Care. 25 Suppl:S27–S33.
  • Fjell CD, Hiss JA, Hancock REW, Schneider G. 2012. Designing antimicrobial peptides: form follows function. Nat Rev Drug Discov. 11:37–51.
  • Foster TJ, Geoghegan JA. 2015. Staphylococcus aureus. In: Tang YW, Sussman M, Liu D, Poxton I, Schwartzman J, editors. Molecular medical microbiology. 2nd ed. Vol. 2. Amsterdam: Academic Press, Elsevier; p. 655–674.
  • Fransway AF, Zug KA, Belsito DV, Deleo VA, Fowler JF Jr, Maibach HI, Marks JG, Mathias CG, Pratt MD, Rietschel RL, et al. 2013. North American Contact Dermatitis Group patch test results for 2007–2008. Dermatitis. 24:10–21.
  • French GL. 2006. Bactericidal agents in the treatment of MRSA infections—the potential role of daptomycin. J Antimicrob Chemother. 58:1107–1117.
  • Friedman AJ, Han G, Navati MS, Chacko M, Gunther L, Alfieri A, Friedman JM. 2008. Sustained release nitric oxide releasing nanoparticles: characterization of a novel delivery platform based on nitrite containing hydrogel/glass composites. Nitric Oxide. 19:12–20.
  • Friedman AJ, Phan J, Schairer DO, Champer J, Qin M, Pirouz A, Blecher-Paz K, Oren A, Liu PT, Modlin RL, Kim J. 2013. Antimicrobial and anti-inflammatory activity of chitosan-alginate nanoparticles: a targeted therapy for cutaneous pathogens. J Invest Dermatol. 133:1231–1239.
  • Fritsche TR, Rhomberg PR, Sader HS, Jones RN. 2008. Antimicrobial activity of omiganan pentahydrochloride tested against contemporary bacterial pathogens commonly responsible for catheter-associated infections. J Antimicrob Chemother. 61:1092–1098.
  • Gambari R. 2014. Peptide nucleic acids: a review on recent patents and technology transfer. Expert Opin Ther Pat. 24:267–294.
  • Ghosal A, Nielsen PE. 2012. Potent antibacterial antisense peptide–peptide nucleic acid conjugates against Pseudomonas aeruginosa. Nucleic Acid Ther. 22:323–334.
  • Glat PM, Kubat WD, Hsu JF, Copty T, Burkey BA, Davis W, Goodwin I. 2009. Randomized clinical study of SilvaSorb gel in comparison to Silvadene silver sulfadiazine cream in the management of partial-thickness burns. J Burn Care Res. 30:262–267.
  • Global leprosy: update on the 2012 situation. 2013. Wkly Epidemiol Rec. 88:365–379.
  • Gordon AK, McIver C, Kim M, Murrell DF,Taylor P. 2016. Clinical application of a molecular assay for the detection of dermatophytosis and a novel non-invasive sampling technique. Pathology. 48:720–726.
  • Guerrero MI, Colorado CL, Torres JF, León CI. 2014. Is drug-resistant Mycobacterium leprae a real cause for concern? First approach to molecular monitoring of multibacillary Colombian patients with and without previous leprosy treatment. Biomedica. 34:137–147.
  • Gunaydin B, Cok OY. 2011. Hazards of topical ophthalmic drug administration. Trends Anaesth Crit Care. 1:31–34.
  • Hadrich I, Makni F, Neji S, Cheikhrouhou F, Bellaaj H, Elloumi M, Ayadi A, Ranque S. 2012. Amphotericin B in vitro resistance is associated with fatal Aspergillus flavus infection. Med Mycol. 50:829–834.
  • Havlickova B, Czaika VA, Friedrich M. 2008. Epidemiological trends in skin mycoses worldwide. Mycoses. 51:2–15.
  • Hay M, Thomas DW, Craighead JL, Economides C, Rosenthal J. 2014. Clinical development success rates for investigational drugs. Nat Biotechnol. 32:40–51.
  • Hay R. 2013. Superficial fungal infections. Medicine. 41:716–718.
  • Hedayati MT, Pasqualotto AC, Warn PA, Bowyer P, Denning DW. 2007. Aspergillus flavus: human pathogen, allergen and mycotoxin producer. Microbiology (Reading, Engl). 153:1677–1692.
  • Hiramatsu K. 1997. Reduced susceptibility of Staphylococcus aureus to vancomycin Japan, 1996. MMWR. 46:624–626.
  • Hirohata A, Hanafusa T, Mabuchi-Kiyohara E, Ikegami R. 2015. Contact dermatitis caused by efinaconazole solution for treatment of onychomycosis. Contact Dermatitis. 73:190–192.
  • Hoban D, Biedenbach D, Sahm D, Reiszner E, Iaconis J. 2015. Activity of ceftaroline and comparators against pathogens isolated from skin and soft tissue infections in Latin America – results of AWARE surveillance 2012. Braz J Infect Dis. 19:596–603.
  • Hryncewicz-Gwóźdź A, Kalinowska K, Plomer-Niezgoda E, Bielecki J, Jagielski T. 2013. Increase in resistance to fluconazole and itraconazole in Trichophyton rubrum clinical isolates by sequential passages in vitro under drug pressure. Mycopathologia. 176:49–55.
  • Jepps OG, Dancik Y, Anissimov YG, Roberts MS. 2013. Modeling the human skin barrier—towards a better understanding of dermal absorption Adv Drug Deliv Rev. 65:152–168.
  • Kalle M, Papareddy P, Kasetty G, Morgelin M, van der Plas MJ, Rydengard V, Malmsten M, Albiger B, Schmidtchen A. 2012. Host defense peptides of thrombin modulate inflammation and coagulation in endotoxin-mediated shock and Pseudomonas aeruginosa sepsis. PLoS One. 7:e51313.
  • Kamai Y, Lossinsky AS, Liu H, Sheppard DC, Filler SG. 2009. Polarized response of endothelial cells to invasion by Aspergillus fumigatus. Cell Microbiol. 11:170–182.
  • Kamal A, Hussaini SM, Sucharitha ML, Poornachandra Y, Sultana F, Ganesh Kumar C. 2015. Synthesis and antimicrobial potential of nitrofuran-triazole congeners. Org Biomol Chem. 13:9388–9397.
  • Karlowsky JA, Biedenbach DJ, Bouchillon SK, Hackel M, Iaconis JP, Sahm DF. 2016. In vitro activity of Ceftaroline against bacterial pathogens isolated from patients with skin and soft tissue and respiratory tract infections in African and Middle Eastern countries: AWARE global surveillance program 2012–2014. Diagn Microbiol Infect Dis. 86:194–199.
  • Karpin GW, Merola JS, Falkinham JO. 2013. Transition metal-α-amino acid complexes with antibiotic activity against Mycobacterium spp. Antimicrob Agents Chemother. 57:3434–3436.
  • Kataoka H, Ida T, Ishii Y, Tateda K, Oguri T, Yoshida A, Okuzumi K, Oishi T, Tsukahara M, Mori S, et al ABX Combination Therapy Study Group (ACTs). 2013. Analysis of the influence of drug resistance factors on the efficacy of combinations of antibiotics for multidrug-resistant Pseudomonas aeruginosa isolated from hospitals located in the suburbs of Kanto area, Japan. JGAR. 1:91–96.
  • Kha P, Colot J, Gervolino S, Guerrier G. 2016. Necrotizing soft-tissue infections in New Caledonia: epidemiology, clinical presentation, microbiology, and prognostic factors. Asian J Surg. Available from: http://dx.doi.org.ezproxy.lb.polyu.edu.hk/10.1016/j.asjsur.2015.10.008.
  • Khattak SU, Bacha N, Lutfullah G, Bakht J, Ali S, Ali J, Khan AA. 2015. Study of the genetic traits associated with antibiotic resistance in Staphylococcus aureus isolated from skin wards of Khyber Pakhtunkhwa, Pakistan. Asian Pac J Trop Dis. 5:393–398.
  • Kniemeyer O, Schmidt AD, Vödisch M, Wartenberg D, Brakhage AA. 2011. Identification of virulence determinants of the human pathogenic fungi Aspergillus fumigatus and Candida albicans by proteomics. Int J Med Microbiol. 301:368–377.
  • Kolar SS, Luca V, Baidouri H, Mannino G, McDermott AM, Mangoni ML. 2015. Esculentin-1a(1-21)NH2: a frog skin-derived peptide for microbial keratitis. Cell Mol Life Sci. 72:617–627.
  • Korting HC, Tietz HJ, Braeutigam M, Mayser P, Rapatz G; Paul C for The LAS-INT-06 study group. 2001. One week terbinafine 1% cream (Lamisil®) once daily is effective in the treatment of interdigital tinea pedis: a vehicle controlled study. Med Mycol. 39:335–340.
  • Krausz AE, Adler BL, Cabral V, Navati M, Doerner J, Charafeddine RA, Chandra D, Liang H, Gunther L, Clendaniel A, et al. 2015. Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent. Nanomedicine. 11:195–206.
  • Kusradze I, Karumidze N, Rigvava S, Dvalidze T, Katsitadze M, Amiranashvili I, Goderdzishvili M. 2016. Characterization and testing the efficiency of Acinetobacter baumannii phage vB-GEC_Ab-M-G7 as an antibacterial agent. Front Microbiol. 7:1590.
  • Lahiri CKK, Jena BJ, Pannicker LCKK. 2009. Mycobacterium fortuitum infections in surgical wounds. Med J Armed Forces India. 65:91–92.
  • Lam KH, Gambari R, Lee KKH, Chen YX, Kok SHL, Wong RSM, Lau FY, Cheng CH, Wong WY, Bian ZX, et al. 2014b. Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus. Bioorg Med Chem Lett. 24:367–370.
  • Lam PL, Gambari R. 2014. Advanced progress of microencapsulation technologies: in vivo and in vitro models for studying oral and transdermal drug deliveries. J Control Release. 178:25–45.
  • Lam PL, Lu GL, Hon KM, Lee KW, Ho CL, Wang X, Tang JCO, Lam KH, Wong RSM, Kok SHL, et al. 2014a. Development of ruthenium(ii) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus. Dalton Trans. 43:3949–3957.
  • Lam PL, Wong WY, Bian ZX, Chui CH, Gambari R. 2017. Recent advances in green nanoparticulate systems for drug delivery: efficient delivery and safety concern. Nanomedicine (Lond.). 12:357–385.
  • Lamb HM, Wiseman LR. 1998. Pexiganan acetate. Drugs. 56:1047–1052. discussion 1053–1044.
  • Landeck L, John SM, Geier J. 2014. Periorbital dermatitis in 4779 patients – patch test results during a 10-year period. Contact Dermatitis. 70:205–212.
  • Landrum ML, Neumann C, Cook C, Chukwuma U, Ellis MW, Hospenthal DR, Murray CK. 2012. Epidemiology of Staphylococcus aureus blood and skin and soft tissue infections in the US military health system, 2005–2010. JAMA. 308:50–59.
  • Lavania M, Jadhav R, Turankar RP, Singh I, Nigam A, Sengupta U. 2015. Genotyping of Mycobacterium leprae strains from a region of high endemic leprosy prevalence in India. Infect Genet Evol. 36:256–261.
  • Lecion D, Fortuna W, Dąbrowska K, Międzybrodzki R, Weber-Dąbrowska B, Górski A. 2013. Application of microbiological quantitative methods for evaluation of changes in the amount of bacteria in patients with wounds and purulent fistulas subjected to phage therapy and for assessment of phage preparation effectiveness (in vitro studies). Adv Med Sci. 58:257–264.
  • Lee GC, Hall RG, Boyd NK, Dallas SD, Du LC, Treviño LB, Treviño SB, Retzloff C, Lawson KA, Wilson J, et al. 2016. A prospective observational cohort study in primary care practices to identify factors associated with treatment failure in Staphylococcus aureus skin and soft tissue infections. Ann Clin Microbiol Antimicrob. 15:58.
  • Li F, Mulyana Y, Feterl M, Warner JM, Collins JG, Keene FR. 2011. The antimicrobial activity of inert oligonuclear polypyridylruthenium(II) complexes against pathogenic bacteria, including MRSA. Dalton Trans. 40:5032–5038.
  • Li X, Chen Y, Gao W, Ouyang W, Wei J, Wen Z. 2016. Epidemiology and outcomes of complicated skin and soft tissue infections among inpatients in Southern China from 2008 to 2013. PLoS ONE. 11:e0149960.
  • Lio PA, Kaye ET. 2011. Topical antibacterial agents. Med Clin N Am. 95:703–721.
  • Liu J, Warshaw EM. 2014. Allergic contact dermatitis from ketoconazole. Cutis. 94:112–114.
  • Loock JW. 2012. A randomised controlled trial of active chronic otitis media comparing courses of eardrops versus one-off topical treatments suitable for primary, secondary and tertiary healthcare settings. Clin Otolaryngol. 37:261–270.
  • Low E, Nair S, Shiau T, Belisle B, Debabov D, Celeri C, Zuck M, Najafi R, Georgopapadakou N, Jain R. 2009. N,N-Dichloroaminosulfonic acids as novel topical antimicrobial agents. Bioorg Med Chem Lett. 19:196–198.
  • Low WL, Martin C, Hill DJ, Kenward MA. 2011. Antimicrobial efficacy of silver ions in combination with tea tree oil against Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans. Int J Antimicrobial Agents. 37:162–165.
  • Low WL, Martin C, Hill DJ, Kenward MA. 2013. Antimicrobial efficacy of liposome-encapsulated silver ions and tea tree oil against Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans. Lett Appl Microbiol. 57:33–39.
  • Lowbury EJL, Hurst L. 1959. The sensitivity of staphylococci and other wound bacteria to erythromycin, oleandomycin, and spiramycin. J Clin Pathol. 12:163–169.
  • Lu Z, Gao J, He Q, Liang D, Yang H, Chen R. 2017. Enhanced antibacterial and wound healing activities of microporous chitosan-Ag/ZnO composite dressing. Carbohydr Polym. 156:460–469.
  • Luca V, Stringaro A, Colone M, Pini A, Mangoni ML. 2013. Esculentin(1-21), an amphibian skin membrane-active peptide with potent activity on both planktonic and biofilm cells of the bacterial pathogen Pseudomonas aeruginosa. Cell Mol Life Sci. 70:2773–2786.
  • Lyon BR, Skurray R. 1987. Antimicrobial resistance of Staphylococcus aureus: genetic basis. Microbiol Rev. 51:88–134.
  • Malhotra R, Ackerman S, Gearinger LS, Morris TW, Allaire C. 2013. The safety of besifloxacin ophthalmic suspension 0.6% used three times daily for 7 days in the treatment of bacterial conjunctivitis. Drugs R D. 13:243–252.
  • Mangoni ML, Luca V, McDermott AM. 2015. Fighting microbial infections: a lesson from amphibian skin-derived esculentin-1 peptides. Peptides. 71:286–295.
  • Manzoni P, Rizzollo S, Monetti C, Carbonara C, Priolo C, Mastretta E, Barberis L, Galletto P, Cigna P, Leonessa ML, et al. 2012. Neonatal cutaneous disseminated aspergillosis in a preterm extremely-low-birth-weight infant with favourable outcome at 3-year follow-up: a case report. Early Hum Dev. 88:S65–S68.
  • Martin D, Fougnot S, Grobost F, Thibaut-Jovelin S, Ballereau F, Gueudet T, de Mouy D, Robert J; ONERBA-ville network. 2016. Prevalence of extended-spectrum beta-lactamase producing Escherichia coli in community-onset urinary tract infections in France in 2013. J Infect. 72:201–206.
  • Martinez E, Pérez JE, Márquez C, Vilacoba E, Centrón D, Leal AL, Saavedra C, Saavedra SY, Tovar C, Vanegas N, Stokes HW. 2013. Emerging and existing mechanisms co-operate in generating diverse β-lactam resistance phenotypes in geographically dispersed and genetically disparate Pseudomonas aeruginosa strains. J Glob Antimicrob Resist. 1:135–142.
  • Martinez LR, Han G, Chacko M, Mihu MR, Jacobson M, Gialanella P, Friedman AJ, Nosanchuk JD, Friedman JM. 2009. Antimicrobial and healing efficacy of sustained release nitric oxide nanoparticles against Staphylococcus aureus skin infection. J Invest Dermatol. 129:2463–2469.
  • Matthijs S, Hernalsteens JP, Roelants K. 2017. An orthologue of the host-defense protein psoriasin (S100A7) is expressed in frog skin. Dev Comp Immunol. 67:395–403.
  • Maya Y, Kaloyan K, Donchev P, Petranka Z, Ivanka P. 2016. Antimicrobial peptides past, present and future. Int J Nutr Food Sci. 5:1–4.
  • Mendem SK, Alasthimannahalli Gangadhara T, Shivannavar CT, Gaddad SM. 2016. Antibiotic resistance patterns of Staphylococcus aureus: a multi center study from India. Microb Pathog. 98:167–170.
  • Mendes JJ, Leandro C, Corte-Real S, Barbosa R, Cavaco-Silva P, Melo-Cristino J, Górski A, Garcia M. 2013. Wound healing potential of topical bacteriophage therapy on diabetic cutaneous wounds. Wound Repair Regen. 21:595–603.
  • Meradji S, Barguigua A, Bentakouk MC, Nayme K, Zerouali K, Mazouz D, Chettibi H, Timinouni M. 2016. Epidemiology and virulence of VIM-4 metallo-beta-lactamase-producing Pseudomonas aeruginosa isolated from burn patients in eastern Algeria. Burns. 42:906–918.
  • Mohanram H, Bhattacharjya S. 2016. 'Lollipop'-shaped helical structure of a hybrid antimicrobial peptide of temporin B-lipopolysaccharide binding motif and mapping cationic residues in antibacterial activity. Biochim Biophys Acta. 1860:1362–1372.
  • Mohseni M, Shamloo A, Aghababaei Z, Vossoughi M, Moravvej H. 2016. Antimicrobial wound dressing containing silver sulfadiazine with high biocompatibility: in vitro study. Artif Organs. 40:765–773.
  • Moore A. 2003. The big and small of drug discovery. Biotech versus pharma: advantages and drawbacks in drug development. EMBO Rep. 4:114–117.
  • Mowad CM, Anderson B, Scheinman P, Pootongkam S, Nedorost S, Brod B. 2016. Allergic contact dermatitis: patient diagnosis and evaluation. J Am Acad Dermatol. 74:1029–1040.
  • Mukherjee PK, Leidich SD, Isham N, Leitner I, Ryder NS, Ghannoum MA. 2003. Clinical Trichophyton rubrum strain exhibiting primary resistance to terbinafine. Antimicrob Agents Chemother. 47:82–86.
  • Mulley G, Jenkins ATA, Waterfield NR. 2014. Inactivation of the antibacterial and cytotoxic properties of silver ions by biologically relevant compounds. PLoS One. 9:e94409.
  • Mun SH, Joung DK, Kim YS, Kang OH, Kim SB, Seo YS, Kim YC, Lee DS, Shin DW, Kweon KT, Kwon DY. 2013. Synergistic antibacterial effect of curcumin against methicillin-resistant Staphylococcus aureus. Phytomedicine. 20:714–718.
  • Naglik JR, Moyes DL, Wächtler B, Hube B. 2011. Candida albicans interactions with epithelial cells and mucosal immunity. Microbes Infect. 13:963–976.
  • Nakae M, Murai T, Kaneko Y, Mitsuhashi S. 1977. Drug resistance in Streptococcus pyogenes isolated in Japan. Antimicrob Agents Chemother. 12:427–428.
  • Nguyen DQ, Righini C, Darouassi Y, Schmerber S. 2011. Nasal infection due to Mycobacterium fortuitum. Eur Ann Otorhinolaryngol Head Neck Dis. 128:197–199.
  • Nguyen TA, Friedman AJ. 2013. Curcumin: a novel treatment for skin-related disorders. J Drugs Dermatol. 12:1131–1137.
  • Nichols DP, Caceres S, Caverly L, Fratelli C, Kim SH, Malcolm K, Poch KR, Saavedra M, Solomon G, Taylor-Cousar J, et al. 2013. Effects of azithromycin in Pseudomonas aeruginosa burn wound infection. J Surg Res. 183:767–776.
  • Nielsen PE, Egholm M, Berg RH, Buchardt O. 1991. Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide. Science. 254:1497–1500.
  • Nigam PK. 2015. Antifungal drugs and resistance: current concepts. Our Dermatol Online. 6:212–221.
  • Oranje AP, Chosidow O, Sacchidanand S, Todd G, Singh K, Scangarella N, Shawar R, Twynholm M; TOC100224 Study Team. 2007. Topical retapamulin ointment, 1%, versus sodium fusidate ointment, 2%, for impetigo: a randomized, observer-blinded, noninferiority study. Dermatology. 215:331–340.
  • Ostorhazi E, Nemes-Nikodem É, Knappe D, Hoffmann R. 2014. In vivo activity of optimized apidaecin and oncocin peptides against a multiresistant, KPC-producing Klebsiella pneumoniae strain. Protein Pept Lett. 21:368–373.
  • Parkash O, Singh BP. 2012. Advances in proteomics of Mycobacterium leprae. Scand J Immunol. 75:369–378.
  • Pasternack MS, Swartz MN. 2015. Cellulitis, necrotizing fasciitis, and subcutaneous tissue infections. In: Bennett JE, Dolin R, Blaser MJ, editors. Mandell, Douglas, and Bennett's principles and practice of infectious diseases. 8th ed. Vol. 1. Philadelphia: Elsevier Saunders; p. 1194–1215.e3.
  • Patenge N, Pappesch R, Krawack F, Walda C, Mraheil MA, Jacob A, HainT, Kreikemeyer B. 2013. Inhibition of growth and gene expression by PNA-peptide conjugates in Streptococcus pyogenes. Mol Ther Nucleic Acids. 2:e132.
  • Patterson TF, Kirkpatrick WR, White M, Hiemenz JW, Wingard JR, Dupont B, Rinaldi MG, Stevens DA, Graybill JR; I3 Aspergillus Study Group. 2000. Invasive aspergillosis: disease spectrum, treatment practices, and outcomes. Medicine (Baltimore). 79:250–260.
  • Pelgrift RY, Friedman AJ. 2013. Nanotechnology as a therapeutic tool to combat microbial resistance. Adv Drug Deliv Rev. 65:1803–1815.
  • Percival SL, Williams DW. 2014. Mycobacterium. In: Percival SL, Yates MV, Williams DW, Chalmers R, Gray N, editors. Microbiology of waterborne diseases (Second Edition), microbiological aspects and risks. London: Academic Press, Elsevier; p. 177–207.
  • Perez RG, Poza-Guedes P, Machín IS, Matheu V. 2014. Contact dermatitis due to topical amorolfine. J Allergy Clin Immunol. 133:AB198.
  • Poyner TF, Dassb BK. 1996. Comparative efficacy and tolerability of fusidic acid/hydrocortisone cream (Fucidin® H cream) and miconazole/hydrocortisone cream (Daktacort® cream) in infected eczema. J Eur Acad Dermatol Venereol. 7:S23–S30.
  • Ray GT, Suaya JA, Baxter R. 2013. Incidence, microbiology, and patient characteristics of skin and soft-tissue infections in a U.S. population: a retrospective population-based study. BMC Infect Dis. 13:252.
  • Readman JB, Dickson G, Coldham NG. 2016. Translational inhibition of CTX-M extended spectrum β-lactamase in clinical strains of Escherichia coli by synthetic antisense oligonucleotides partially restores sensitivity to cefotaxime. Front Microbiol. 7:373.
  • Reglinski R, Sriskandan MS. 2015. Streptococcus pyogenes. In: Tang YW, Sussman M, Liu D, Poxton I, Schwartzman J, editors. Molecular medical microbiology. 2nd ed. Vol. 2. Amsterdam: Academic Press, Elsevier; p. 675–716.
  • Renteria MI, Biedenbach DJ, Bouchillon SK, Hoban DJ, Raghubir N, Sajben P, Mokaddas E. 2014. In vitro activity of tigecycline against isolates collected from complicated skin and skin structure infections and intra-abdominal infections in Africa and Middle East countries: TEST 2007–2012. Diagn Microbiol Infect Dis. 79:54–59.
  • Richter SS, Heilmann KP, Dohrn CL, Beekmann SE, Riahi F, Garcia-de-Lomas J, Ferech M, Goossens H, Doern GV. 2008. Increasing telithromycin resistance among Streptococcus pyogenes in Europe. J Antimicrob Chemother. 61:603–611.
  • Rist T, Parish LC, Capin LR, Sulica V, Bushnell WD, Cupo MA. 2002. A comparison of the efficacy and safety of mupirocin cream and cephalexin in the treatment of secondarily infected eczema. Clin Exp Dermatol. 27:14–20.
  • Rumbaugh KP, Hamood AN, Griswold JA. 2004. Cytokine induction by the P. aeruginosa quorum sensing system during thermal injury. J Surg Res. 116:137–144.
  • Sader HS, Farrell DJ, Mendes RE, Flamm RK, Castanheira M, Jones RN. 2015. Antimicrobial activity of ceftaroline tested against bacterial isolates causing respiratory tract and skin and skin structure infections in US medical centers in 2013. Diagn Microbiol Infect Dis. 82:78–84.
  • Samgina TY, Vorontsov EA, Gorshkov VA, Hakalehto E, Hanninen O, Zubarev RA, Lebedev AT. 2012. Composition and antimicrobial activity of the skin peptidome of Russian brown frog Rana temporaria. J Proteome Res. 11:6213–6222.
  • Sanchez DA, Schairer D, Tuckman-Vernon C, Chouake J, Kutner A, Makdisi J, Friedman JM, Nosanchuk JD, Friedman AJ. 2014. Amphotericin B releasing nanoparticle topical treatment of Candida spp. in the setting of a burn wound. Nanomedicine. 10:269–277.
  • Sandreschi S, Piras AM, Batoni G, Chiellini F. 2016. Perspectives on polymeric nanostructures for the therapeutic application of antimicrobial peptides. Nanomedicine (Lond). 11:1729–1744.
  • Sankar R, Baskaran A, Shivashangari KS, Ravikumar V. 2015. Inhibition of pathogenic bacterial growth on excision wound by green synthesized copper oxide nanoparticles leads to accelerated wound healing activity in Wistar Albino rats. J Mater Sci Mater Med. 26:214.
  • Santos VR, Gomes RT, de Mesquita RA, de Moura MD, França EC, de Aguiar EG, Naves MD, Abreu JA, Abreu SR. 2008. Efficacy of Brazilian propolis gel for the management of denture stomatitis: a pilot study. Phytother Res. 22:1544–1547.
  • Sawai J, Hasegawa T, Kamimura T, Okamoto A, Ohmori D, Nosaka N, Yamada K, Torii K, Ohta M. 2007. Growth phase-dependent effect of clindamycin on production of exoproteins by Streptococcus pyogenes. Antimicrob Agents Chemother. 51:461–467.
  • Sawyer AJ, Wesolowski D, Gandotra N, Stojadinovic A, Izadjoo M, Altman S, Kyriakides TR. 2013. A peptide-morpholino oligomer conjugate targeting Staphylococcus aureus gyrA mRNA improves healing in an infected mouse cutaneous wound model. Int J Pharm. 453:651–655.
  • Seidman LS, Skokos CK. 2005. An evaluation of butoconazole nitrate 2% site release vaginal cream (Gynazole-1) compared to fluconazole 150 mg tablets (Diflucan) in the time to relief of symptoms in patients with vulvovaginal candidiasis. Infect Dis Obstet Gynecol. 13:197–206.
  • Shao W, Wu J, Wang S, Huang M, Liu X, Zhang R. 2017. Construction of silver sulfadiazine loaded chitosan composite sponges as potential wound dressings. Carbohydrate Polym. 157:1963–1970.
  • Shi D, Xi X, Wang L, Gao Y, Ma C, Chen H, Zhou M, Chen T, Shaw C. 2016. Baltikinin: a new myotropic tryptophyllin-3 peptide isolated from the skin secretion of the purple-sided leaf frog, Phyllomedusa baltea. Toxins (Basel). 8:E213.
  • Shiau TP, Low E, Kim B, Turtle ED, Francavilla C, O'Mahony DJ, Friedman L, D'Lima L, Jekle A, Debabov D, et al. 2013. Sulfonyl-polyol N,N-dichloroamines with rapid, broad-spectrum antimicrobial activity. Bioorg Med Chem Lett. 23:5650–5653.
  • Shiau TP, Turtle ED, Francavilla C, Alvarez NJ, Zuck M, Friedman L, O'Mahony DJ, Low E, Anderson MB, Najafi RR, Jain RK. 2011. Novel 3-chlorooxazolidin-2-ones as antimicrobial agents. Bioorg Med Chem Lett. 21:3025–3028.
  • Silva LB, de Oliveira DB, da Silva BV, de Souza RA, da Silva PR, Ferreira-Paim K, Andrade-Silva LE, Silva-Vergara ML, Andrade AA. 2014. Identification and antifungal susceptibility of fungi isolated from dermatomycoses. J Eur Acad Dermatol Venereol. 28:633–640.
  • Singla R, Soni S, Kulurkar PM, Kumari A, SM, Patial V, Padwad YS, Yadav SK. 2017. In situ functionalized nanobiocomposites dressings of bamboo cellulose nanocrystals and silver nanoparticles for accelerated wound healing. Carbohydr Polym. 155:152–162.
  • Sinha R, Agarwal RK, Agarwal M. 1997. Povidone iodine plus neosporin in superficial burns—a continuing study. Burns. 23:626–628.
  • Smith GS, Ghio AJ, Stout JE, Messier KP, Hudgens EE, Murphy MS, Pfaller SL, Maillard JM, Hilborn ED. 2016. Epidemiology of nontuberculous mycobacteria isolations among central North Carolina residents, 2006–2010. J Infect. 72:678–686.
  • Sommer S, Bojar R, Cunliffe WJ, Holland D, Holland KT, Naags H. 1997. Investigation of the mechanism of action of 2% fusidic acid lotion in the treatment of acne vulgaris. Clin Exp Dermatol. 22:211–215.
  • Spring S, Pratt M, Chaplin A. 2012. Contact dermatitis to topical medicaments: a retrospective chart review from the Ottawa Hospital Patch Test Clinic. Dermatitis. 23:210–213.
  • Steer AC, Carapetis JR, Dale JB, Fraser JD, Good MF, Guilherme L, Moreland NJ, Mulholland EK, Schodel F, Smeesters PR. 2016. Status of research and development of vaccines for Streptococcus pyogenes. Vaccine. 34:2953–2958.
  • Stevens DA, Kan VL, Judson MA, Morrison VA, Dummer S, Denning DW, Bennett JE, Walsh TJ, Patterson TF, Pankey GA. 2000. Practice guidelines for diseases caused by Aspergillus. Infectious Diseases Society of America. Clin Infect Dis. 30:696–709.
  • Stevens DL, Bisno AL, Chambers HF, Everett ED, Dellinger P, Goldstein EJ, Gorbach SL, Hirschmann JV, Kaplan EL, Montoya JG, Wade JC. 2005. Infectious Diseases Society of America, Practice guidelines for the diagnosis and management of skin and soft-tissue infections. Clin Infect Dis. 41:1373–1406.
  • Suschka S, Fladung B, Merk HF. 2002. Clinical comparison of the efficacy and tolerability of once daily Canesten with twice daily Nizoral (clotrimazole 1% cream vs. ketoconazole 2% cream) during a 28-day topical treatment of interdigital tinea pedis. Mycoses. 45:91–96.
  • Sykes JE. 2014. Gram-negative bacterial infections. In: Sykes JE, editor. Canine and feline infectious diseases. Missouri: Elsevier Saunders; p. 355–363.
  • Tanaka Y, Gotoh K, Teramachi M, Ishimoto K, Tsumura N, Shindou S, Yamashita Y. 2016. Molecular epidemiology, antimicrobial susceptibility, and characterization of macrolide-resistant Streptococcus pyogenes in Japan. J Infect Chemother. 22:727–732.
  • Tang MM, Corti MA, Stirnimann R, Pelivani N, Yawalkar N, Borradori L, Simon D. 2013. Severe cutaneous allergic reactions following topical antifungal therapy. Contact Dermatitis. 68:56–57.
  • Tang SS, Lye DC, Jureen R, Sng LH, Hsu LY. 2015. Rapidly growing mycobacteria in Singapore, 2006–2011. Clin Microbiol Infect. 21:236–241.
  • Thapaliya D, O'Brien AM, Wardyn SE, Smith TC. 2015. Epidemiology of necrotizing infection caused by Staphylococcus aureus and Streptococcus pyogenes at an Iowa hospital. J Infect Public Health. 8:634–641.
  • The Topical/Transdermal Ad Hoc Advisory Panel for the USP Performance Tests of Topical and Transdermal Dosage Forms: Ueda CT, Shah VP, Derdzinski K, Ewing G, Flynn G, Maibach H, Marques M, Rytting H, Shaw S, Thakker K, Yacobi A. 2009. Topical and Transdermal Drug Products. Pharmacopeial Forum. 35:750–764.
  • Török ME, Conlon CP. 2013. Skin and soft tissue infections. Medicine. 41:709–715.
  • Trookman NS, Rizer RL, Weber T. 2011. Irritation and allergy patch test analysis of topical treatments commonly used in wound care: evaluation on normal and compromised skin. J Am Acad Dermatol. 64:S16–S22.
  • Uccelletti D, Zanni E, Marcellini L, Palleschi C, Barra D, Mangoni ML. 2010. Anti-Pseudomonas activity of frog skin antimicrobial peptides in a Caenorhabditis elegans infection model: a plausible mode of action in vitro and in vivo. Antimicrob Agents Chemother. 54:3853–3860.
  • Uz Zaman T, Aldrees M, Al Johani SM, Alrodayyan M, Aldughashem FA, Balkhy HH. 2014. Multi-drug carbapenem-resistant Klebsiella pneumoniae infection carrying the OXA-48 gene and showing variations in outer membrane protein 36 resulting in an outbreak in a tertiary care hospital in Riyadh, Saudi Arabia. Int. J Infect Dis. 28:186–192.
  • Velasco A, Román C, Aragüés M, Noguera X, Ventura C, Lerís E. 2002. Comparison of the efficacy of 1% flutrimazole cream twice a day with 1% flutrimazole cream once a day for the treatment of superficial dermatophytoses. Rev Iberoam Micol. 19:169–172.
  • Walsh TL, Chan L, Konopka CI, Burkitt MJ, Moffa MA, Bremmer DN, Murillo MA, Watson C, Chan-Tompkins NH. 2016. Appropriateness of antibiotic management of uncomplicated skin and soft tissue infections in hospitalized adult patients. BMC Infect Dis. 16:721.
  • Warshaw EM, Ahmed RL, Belsito DV, DeLeo VA, Fowler JF Jr, Maibach HI, Marks JG Jr, Toby Mathias CG, Pratt MD, et al., North American Contact Dermatitis Group. 2007. Contact dermatitis of the hands: cross-sectional analyses of North American Contact Dermatitis Group Data, 1994–2004. J Am Acad Dermatol. 57:301–314.
  • Warshaw EM, Belsito DV, Taylor JS, Sasseville D, DeKoven JG, Zirwas MJ, Fransway AF, Mathias CG, Zug KA, DeLeo VA, et al. 2013. North American Contact Dermatitis Group patch test results: 2009 to 2010. Dermatitis. 24:50–59.
  • Warshaw EM, Maibach HI, Taylor JS, Sasseville D, DeKoven JG, Zirwas MJ, Fransway AF, Mathias CG, Zug KA, DeLeo VA, et al. 2015. North American contact dermatitis group patch test results: 2011–2012. Dermatitis. 26:49–59.
  • WHO. 2013. Global leprosy: update on the 2012 situation. 2013. Weekly Epidemiological Record, No. 35, vol. 88; p. 365–380.
  • WHO. 2016. Global leprosy update, 2015: time for action, accountability and inclusion. Weekly Epidemiological Record, No. 35, vol. 91; p. 405–420.
  • Williams DL, Lewis C, Sandoval FG, Robbins N, Keas S, Gillis TP, Scollard DM . 2014. Drug resistance in patients with leprosy in the United States. Clin Infect Dis. 58:72–73.
  • Williams JD, Torhan MC, Neelagiri VR, Brown C, Bowlin NO, Di M, McCarthy CT, Aiello D, Peet NP, Bowlin TL, Moir DT. 2015. Synthesis and structure–activity relationships of novel phenoxyacetamide inhibitors of the Pseudomonas aeruginosa type III secretion system (T3SS). Bioorg Med Chem. 23:1027–1043.
  • Winthrop KL, Albridge K, South D, Albrecht P, Abrams M, Samuel MC, Leonard W, Wagner J, Vugia DJ. 2004. The clinical management and outcome of nail salon-acquired Mycobacterium fortuitum skin infection. Clin Infect Dis. 38:38–44.
  • Wu T, Cheng D, He M, Pan S, Yao X, Xu X. 2014. Antifungal action and inhibitory mechanism of polymethoxylated flavones from Citrus reticulata Blanco peel against Aspergillus niger. Food Control. 35:354–359.
  • Xu Z, Xie J, Peters BM, Li B, Li L, Yu G, Shirtliff ME. 2017. Longitudinal surveillance on antibiogram of important Gram-positive pathogens in Southern China, 2001 to 2015. Microb Pathog. 103:80–86.
  • Yabanoglu H, Basaran O, Aydogan C, Azap OK, Karakayali F, Moray G. 2013. Assessment of the effectiveness of silver-coated dressing, chlorhexidine acetate (0.5%), citric acid (3%), and silver sulfadiazine (1%) for topical antibacterial effects against the multi-drug resistant Pseudomonas aeruginosa infecting full-skin thickness burn wounds on rats. Int Surg. 98:416–423.
  • Yamaguchi T, Koga M, Arao Y, Tokumaru R, Takahashi A, Yoshida Y, Kubota Y, Nakayama J. 2007. Efficacy of luliconazole 1% cream (lulicon cream 1%) for tinea pedis. Nishi Nihon Hifuka. 69:547–553.
  • Yamamoto T, Takano T, Fusegawa T, Shibuya T, Hung WC, Higuchi W, Iwao Y, Khokhlova O, Reva I. 2013. Electron microscopic structures, serum resistance, and plasmid restructuring of New Delhi metallo-β-lactamase-1 (NDM-1)-producing ST42 Klebsiella pneumoniae emerging in Japan. J Infect Chemother. 19:118–127.
  • Yang L, Su MQ, Ma YY, Xin YJ, Han RB, Zhang R, Wen J, Hao XK. 2016. Epidemiology, species distribution, antifungal susceptibility, and ERG11 mutations of Candida species isolated from pregnant Chinese Han women. Genet Mol Res. 15: gmr.15027168.
  • Yenisehirli G, Bulut N, Yenisehirli A, Bulut Y. 2015. In vitro susceptibilities of Candida albicans isolates to antifungal agents in Tokat, Turkey. Jundishapur J Microbiol. 8:e28057.
  • Yu JR, Heo ST, Lee KH, Kim J, Sung JK, Kim YR, Kim JW. 2013. Skin and soft tissue infection due to rapidly growing mycobacteria: case series and literature review. Infect Chemother. 45:85–93.
  • Zhao Z, Ma L. 2015. Skin and soft tissue infections: a clinical overview. In: Tang YW, Sussman M, Liu D, Poxton I, Schwartzman J, editors. Molecular medical microbiology. 2nd ed. Vol. 2. Amsterdam: Academic Press, Elsevier; p. 825–835.
  • Zipfel PF, Skerka C, Kupka D, Luo S. 2011. Immune escape of the human facultative pathogenic yeast Candida albicans: the many faces of the Candida Pra1 protein. Int J Med Microbiol. 301:423–430.
  • Zug KA, Warshaw EM, Fowler JF, Jr, Maibach HI, Belsito DL, Pratt MD, Sasseville D, Storrs FJ, Taylor JS, Mathias CG, et al. 2009. Patch-test results of the North American Contact Dermatitis Group 2005–2006. Dermatitis. 20:149–160.
  • Zurfluh K, Hächler H, Nüesch-Inderbinen M, Stephan R. 2013. Characteristics of extended-spectrum β-lactamase- and carbapenemase-producing Enterobacteriaceae isolates from rivers and lakes in Switzerland. Appl Environ Microbiol. 79:3021–3026.

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