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Review Articles

Exploring the putative interactions between chronic kidney disease and chronic periodontitis

, , , , & ORCID Icon
Pages 61-77 | Received 14 Nov 2019, Accepted 20 Jan 2020, Published online: 12 Feb 2020

References

  • Addy M, Hunter ML. 2003. Can tooth brushing damage your health? Effects on oral and dental tissues. Int Dent J. 53:177–186.
  • Aderem A, Ulevitch RJ. 2000. Toll-like receptors in the induction of the innate immune response. Nature. 406:782–787.
  • Ahn SY, Ingulli E. 2008. Acute poststreptococcal glomerulonephritis: an update. Curr Opin Pediatr. 20:157–162.
  • Aitken G. 2014. Analysis of estimates of CKD prevalence across England. England PH. http://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/612303/ChronickidneydiseaseCKDprevalencemodelbriefing.pdf.
  • Akar H, Akar GC, Carrero JJ, Stenvinkel P, Lindholm B. 2011. Systemic consequences of poor oral health in chronic kidney disease patients. Clin J Am Soc Nephrol. 6:218–226.
  • Akpan A, Morgan R. 2002. Oral candidiasis. Postgrad Med J. 78:455–459.
  • Albandar JM, Kingman A. 1999. Gingival recession, gingival bleeding, and dental calculus in adults 30 years of age and older in the United States, 1988–1994. J Periodontol. 70:30–43.
  • Al-Hebshi NN, Shuga-Aldin HM, Al-Sharabi AK, Ghandour I. 2014. Subgingival periodontal pathogens associated with chronic periodontitis in Yemenis. BMC Oral Health. 14:13.
  • Alkjaersig NK, Fletcher AP, Lewis ML, Cole BR, Ingelfinger JR, Robson AM. 1976. Pathophysiological response of the blood coagulation system in acute glomerulonephritis. Kidney Int. 10:319–328.
  • Almroth G, Lindell Å, Åselius H, Sörén L, Svensson L, Hultman P, Eribe ERK, Olsen I. 2005. Acute glomerulonephritis associated with Streptococcus pyogenes with concomitant spread of Streptococcus constellatus in four rural families. Upsala J Med Sci. 110:217–231.
  • Ambrosioni J, Hernandez-Meneses M, Téllez A, Pericàs J, Falces C, Tolosana JM, Vidal B, Almela M, Quintana E, Llopis J, et al. 2017. The changing epidemiology of infective endocarditis in the twenty-first century. Curr Infect Dis Rep. 19:21.
  • Anand N, Chandrasekaran SC, Alam MN. 2013. The malnutrition inflammation complex syndrome – the micsing factor in the perio-chronic kidney disease interlink. J Clin Diagn Res. 7:763–767.
  • Ariyamuthu VK, Nolph KD, Ringdahl BE. 2013. Periodontal disease in chronic kidney disease and end-stage renal disease patients: a review. Cardiorenal Med. 3:71–78.
  • Arora N, Mishra A, Chugh S. 2014. Microbial role in periodontitis: have we reached the top? Some unsung bacteria other than red complex. J Indian Soc Periodontol. 18:9–13.
  • Avlund K, Schultz-Larsen K, Krustrup U, Christiansen N, Holm-Pedersen P. 2009. Effect of inflammation in the periodontium in early old age on mortality at 21-year follow-up. J Am Geriatr Soc. 57:1206–1212.
  • Baddour LM, Wilson WR, Bayer AS, Fowler VG, Tleyjeh IM, Rybak MJ, Barsic B, Lockhart PB, Gewitz MH, Levison ME, Bolger AF. 2015. Infective endocarditis in adults: diagnosis, antimicrobial therapy, and management of complications. Circulation. 132:1435–1486.
  • Bastos JA, Diniz CG, Bastos MG, Vilela EM, Silva VL, Chaoubah A, Souza-Costa DC, Andrade LCF. 2011. Identification of periodontal pathogens and severity of periodontitis in patients with and without chronic kidney disease. Arch Oral Biol. 56:804–811.
  • Bayer AS, Theofilopoulos AN. 1990. Immunopathogenetic aspects of infective endocarditis. Chest. 97:204–212.
  • Beck JD, Moss KL, Morelli T, Offenbacher S. 2018. Periodontal profile class is associated with prevalent diabetes, coronary heart disease, stroke, and systemic markers of C-reactive protein and interleukin-6. J Periodontol. 89:157–165.
  • Bharti V, Bansal C. 2013. Drug-induced gingival overgrowth: the nemesis of gingiva unravelled. J Indian Soc Periodontol. 17:182–187.
  • Billings F. 1916. Focal infection. New York: D. Appleton.
  • Boils CL, Nasr SH, Walker PD, Couser WG, Larsen CP. 2015. Update on endocarditis-associated glomerulonephritis. Kidney Int. 87:1241–1249.
  • Borawski J, Wilczynska-Borawska M, Stokowska W, Mysliwiec M. 2006. The periodontal status of pre-dialysis chronic kidney disease and maintenance dialysis patients. Nephrol Dial Transplant. 22:457–464.
  • Bosshardt DD. 2017. The periodontal pocket: pathogenesis, histopathology and consequences. Periodontol 2000. 76:43–50.
  • Bots CP, Poorterman JHG, Brand HS, Kalsbeek H, Amerongen BM, Veerman ECI, Nieuw Amerongen AV. 2006. The oral health status of dentate patients with chronic renal failure undergoing dialysis therapy. Oral Dis. 12:176–180.
  • Brodsky SV, Nadasdy T. 2017. Acute poststreptococcal glomerulonephritis. In: Satoskar AA, Nadasdy T, editors. Bacterial infections and the kidney. Cham: Springer International Publishing.
  • Brown RS, Arany PR. 2015. Mechanism of drug-induced gingival overgrowth revisited: a unifying hypothesis. Oral Dis. 21:e51–e61.
  • Byrne SJ, Dashper SG, Darby IB, Adams GG, Hoffmann B, Reynolds EC. 2009. Progression of chronic periodontitis can be predicted by the levels of Porphyromonas gingivalis and Treponema denticola in subgingival plaque. Oral Microbiol Immunol. 24:469–477.
  • Cabell CH, Abrutyn E, Karchmer AW. 2003. Bacterial endocarditis. Circulation. 107:e185–e187.
  • Carapetis JR, Steer AC, Mulholland EK, Weber M. 2005. The global burden of group A streptococcal diseases. Lancet Infect Dis. 5:685–694.
  • Carmona IT, Dios PD, Scully C. 2002. An update on the controversies in bacterial endocarditis of oral origin. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 93:660–670.
  • Caton JG, Armitage G, Berglundh T, Chapple IL, Jepsen S, Kornman KS, Mealey BL, Papapanou PN, Sanz M, Tonetti MS. 2018. A new classification scheme for periodontal and peri-implant diseases and conditions – introduction and key changes from the 1999 classification. J Periodontol. 89:S1–S8.
  • Chambrone L, Foz AM, Guglielmetti MR, Pannuti CM, Artese HPC, Feres M, Romito GA. 2013. Periodontitis and chronic kidney disease: a systematic review of the association of diseases and the effect of periodontal treatment on estimated glomerular filtration rate. J Clin Periodontol. 40:443–456.
  • Chen LP, Chiang CK, Chan CP, Hung KY, Huang CS. 2006. Does periodontitis reflect inflammation and malnutrition status in hemodialysis patients? Am J Kidney Dis. 47:815–822.
  • Chen LP, Chiang CK, Peng YS, Hsu SP, Lin CY, Lai CF, Hung KY. 2011. Relationship between periodontal disease and mortality in patients treated with maintenance hemodialysis. Am J Kidney Dis. 57:276–282.
  • Cohen G, Hörl WH. 2012. Immune dysfunction in uremia—an update. Toxins (Basel). 4:962–990.
  • Coresh J. 2017. Update on the burden of CKD. J Am Soc Nephrol. 28:1020–1022.
  • Couser WG, Remuzzi G, Mendis S, Tonelli M. 2011. The contribution of chronic kidney disease to the global burden of major noncommunicable diseases. Kidney Int. 80:1258–1270.
  • Coykendall AL. 1989. Classification and identification of the viridans streptococci. Clin Microbiol Rev. 2:315–328.
  • Craig RG. 2007. Interactions between chronic renal disease and periodontal disease. Oral Dis. 14:1–7.
  • Cronin W, Deol H, Azadegan A, Lange K. 1989. Endostreptosin: isolation of the probable immunogen of acute post-streptococcal glomerulonephritis (PSGN). Clin Exp Immunol. 76:198–203.
  • Darveau RP. 2010. Periodontitis: a polymicrobial disruption of host homeostasis. Nat Rev Microbiol. 8:481–490.
  • Dashper SG, Seers CA, Tan KH, Reynolds EC. 2011. Virulence factors of the oral spirochete Treponema denticola. J Dent Res. 90:691–703.
  • De La Rosa Garcia E, Mondragon Padilla A, Aranda Romo S, Bustamante Ramirez MA. 2006. Oral mucosa symptoms, signs and lesions, in end stage renal disease and non-end stage renal disease diabetic patients. Med Oral Patol Oral Cir Bucal. 11:E467–E473.
  • De Rossi SS, Glick M. 1996. Dental considerations for the patient with renal disease receiving hemodialysis. J Am Dent Assoc. 127:211–219.
  • Deshpande RG, Khan MB, Genco CA. 1998. Invasion of aortic and heart endothelial cells by Porphyromonas gingivalis. Infect Immun. 66:5337–5343.
  • Dewhirst FE, Chen T, Izard J, Paster BJ, Tanner ACR, Yu WH, Lakshmanan A, Wade WG. 2010. The human oral microbiome. J Bacteriol. 192:5002–5017.
  • Dhondup T, Qian Q. 2017. Electrolyte and acid–base disorders in chronic kidney disease and end-stage kidney failure. Blood Purif. 43:179–188.
  • Dietrich T, Jimenez M, Krall Kaye EA, Vokonas PS, Garcia RI. 2008. Age-dependent associations between chronic periodontitis/edentulism and risk of coronary heart disease. Circulation. 117:1668–1674.
  • Dominy SS, Lynch C, Ermini F, Benedyk M, Marczyk A, Konradi A, Nguyen M, Haditsch U, Raha D, Griffin C, et al. 2019. Porphyromonas gingivalis in Alzheimer’s disease brains: evidence for disease causation and treatment with small-molecule inhibitors. Sci Adv. 5:eaau3333.
  • Dyck RF, Hayward MN, Harris SB. 2012. Prevalence, determinants and co-morbidities of chronic kidney disease among First Nations adults with diabetes: results from the CIRCLE study. BMC Nephrol. 13:57.
  • Dye BA, Choudhary K, Shea S, Papapanou PN. 2005. Serum antibodies to periodontal pathogens and markers of systemic inflammation. J Clin Periodontol. 32:1189–1199.
  • Earle DP. 1985. Poststreptococcal acute glomerulonephritis. Hosp Pract. 20:84E–84BB.
  • Edgar WM, O’Mullane DM, Dawes C. 2004. Saliva and oral health. London: British Dental Association.
  • Engebretson SP, Hyman LG, Michalowicz BS, Schoenfeld ER, Gelato MC, Hou W, Seaquist ER, Reddy MS, Lewis CE, Oates TW, et al. 2013. The effect of nonsurgical periodontal therapy on hemoglobin a1c levels in persons with type 2 diabetes and chronic periodontitis: a randomized clinical trial. JAMA. 310:2523–2532.
  • Epstein SR, Mandel I, Scopp IW. 1980. Salivary composition and calculus formation in patients undergoing hemodialysis. J Periodontol. 51:336–338.
  • Everett ED, Hirschmann JV. 1977. Transient bacteremia and endocarditis prophylaxis. A review. Medicine. 56:61–77.
  • Finn WF. 1977. Renal response to environmental toxics. Environ Health Perspect. 20:15.
  • Fisher MA, Borgnakke WS, Taylor GW. 2010. Periodontal disease as a risk marker in coronary heart disease and chronic kidney disease. Curr Opin Nephrol Hypertens. 19:519–526.
  • Fisher MA, Taylor GW, West BT, McCarthy ET. 2011. Bidirectional relationship between chronic kidney and periodontal disease: a study using structural equation modeling. Kidney Int. 79:347–355.
  • Flemmig TF. 1999. Periodontitis. Ann Periodontol. 4:32–38.
  • Frencken JE, Sharma P, Stenhouse L, Green D, Laverty D, Dietrich T. 2017. Global epidemiology of dental caries and severe periodontitis – a comprehensive review. J Clin Periodontol. 44:S94–S105.
  • Fukui K, Kato N, Kato H, Watanabe K, Tatematsu N. 1999. Incidence of Prevotella intermedia and Prevotella nigrescens carriage among family members with subclinical periodontal disease. J Clin Microbiol. 37:3141–3145.
  • Gendron R, Grenier D, Maheu-Robert LF. 2000. The oral cavity as a reservoir of bacterial pathogens for focal infections. Microb Infect. 2:897–906.
  • German RZ, Palmer JB. 2006. Anatomy and development of oral cavity and pharynx. GI Motility Online.
  • Grubbs V, Plantinga LC, Tuot DS, Powe NR. 2012. Chronic kidney disease and use of dental services in a United States public healthcare system: a retrospective cohort study. BMC Nephrol. 13:16.
  • Gualtero DF, Lafaurie GI, Fontanilla MR. 2018. Two-dimensional and three-dimensional models for studying atherosclerosis pathogenesis induced by periodontopathogenic microorganisms. Mol Oral Microbiol. 33:29–37.
  • Guan SM, Shu L, Fu SM, Liu B, Xu XL, Wu JZ. 2008. Prevotella intermedia induces matrix metalloproteinase-9 expression in human periodontal ligament cells. FEMS Microbiol Lett. 283:47–53.
  • Haag-Weber M, Horl WH. 1996. Dysfunction of polymorphonuclear leukocytes in uremia. Semin Nephrol. 16:192–201.
  • Haffajee AD, Teles RP, Socransky SS. 2006. Association of Eubacterium nodatum and Treponema denticola with human periodontitis lesions. Oral Microbiol Immunol. 21:269–282.
  • Hajishengallis G. 2009. Porphyromonas gingivalis-host interactions: open war or intelligent guerilla tactics? Microbes Infect. 11:637–645.
  • Hajishengallis G. 2015. Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol. 15:30–44.
  • Hajishengallis G, Lamont RJ. 2012. Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology. Microbiol Oral Immunol. 27:409–419.
  • Hamer RA, El Nahas AM. 2006. The burden of chronic kidney disease: is rising rapidly worldwide. BMJ. 332:563–564.
  • Han YW, Redline RW, Li M, Yin L, Hill GB, McCormick TS. 2004. Fusobacterium nucleatum induces premature and term stillbirths in pregnant mice: implication of oral bacteria in preterm birth. Infect Immun. 72:2272–2279.
  • Heidari E, Banerjee A, Newton JT. 2015. Oral health status of non-phobic and dentally phobic individuals; a secondary analysis of the 2009 Adult Dental Health Survey. Br Dent J. 219:E9.
  • Hemmelgarn BR, Manns BJ, Lloyd A, James MT, Klarenbach S, Quinn RR, Wiebe N, Tonelli M, Alberta Kidney Disease N. 2010. Relation between kidney function, proteinuria, and adverse outcomes. JAMA. 303:423–429.
  • Henderson B, Ward JM, Ready D. 2010. Aggregatibacter (Actinobacillus) actinomycetemcomitans: a triple A* periodontopathogen? Periodontol 2000. 54:78–105.
  • Hendrickson EL, Beck DAC, Miller DP, Wang Q, Whiteley M, Lamont RJ, Hackett M. 2017. Insights into dynamic polymicrobial synergy revealed by time-coursed RNA-Seq. Front Microbiol. 8:261.
  • Honarmand M, Farhad-Mollashahi L, Nakhaee A, Sargolzaie F. 2017. Oral manifestation and salivary changes in renal patients undergoing hemodialysis. J Clin Exp Dent. 9:e207–e210.
  • Hoy WE, Hughson MD, Bertram JF, Douglas-Denton R, Amann K. 2005. Nephron number, hypertension, renal disease, and renal failure. J Am Soc Nephrol. 16:2557–2564.
  • Hruska KA, Mathew S, Lund R, Qiu P, Pratt R. 2008. Hyperphosphatemia of chronic kidney disease. Kidney Int. 74:148–157.
  • Inker LA, Astor BC, Fox CH, Isakova T, Lash JP, Peralta CA, Kurella Tamura M, Feldman HI. 2014. KDOQI US Commentary on the 2012 KDIGO clinical practice guideline for the evaluation and management of CKD. Am J Kidney Dis. 63:713–735.
  • Inker LA, Levey AS. 2014. 53 – staging and management of chronic kidney disease. In: Gilbert SJ, Weiner DE, editors. National kidney foundation primer on kidney diseases. 6th ed. Philadelphia (PA): W.B. Saunders.
  • Ishikawa M, Yoshida K, Okamura H, Ochiai K, Takamura H, Fujiwara N, Ozaki K. 2013. Oral Porphyromonas gingivalis translocates to the liver and regulates hepatic glycogen synthesis through the Akt/GSK-3β signaling pathway. Biochim Biophys Acta. 1832:2035–2043.
  • Ismail FB, Ismail G, Dumitriu AS, Baston C, Berbecar V, Jurubita R, Andronesi A, Dumitriu HT, Sinescu I. 2015. Identification of subgingival periodontal pathogens and association with the severity of periodontitis in patients with chronic kidney diseases: a cross-sectional study. Biomed Res Int. 2015:1–7.
  • Jameson JL, Loscalzo J. 2016. Harrison’s nephrology and acid–base disorders. 3rd ed. New York: McGraw-Hill Education.
  • Jawetz M. 2007. Adelberg’s medical microbiology. Antibacterial and antifungal chemotherapy. Prentice-Hall International. http://books.google.co.uk/books?id=C9JpAAAAMAAJ&q=Adelberg%E2%80%99s+medical+microbiology.+Antibacterial+and+antifungal+chemotherapy.&dq=Adelberg%E2%80%99s+medical+microbiology.+Antibacterial+and+antifungal+chemotherapy.&hl=en&sa=X&ved=0ahUKEwjoqNLQ67_nAhU-QUEAHQ7lCkAQ6AEIKTAA.
  • Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, Saran R, Wang AYM, Yang CW. 2013. Chronic kidney disease: global dimension and perspectives. Lancet. 382:260–272.
  • Jones R. 2010. Chronic disease and comorbidity. Br J Gen Pract. 60:394–394.
  • Judd E, Calhoun DA. 2015. Management of hypertension in CKD: beyond the guidelines. Adv Chronic Kidney Dis. 22:116–122.
  • Kalantar-Zadeh K, Shah A, Duong U, Hechter RC, Dukkipati R, Kovesdy CP. 2010. Kidney bone disease and mortality in CKD: revisiting the role of vitamin D, calcimimetics, alkaline phosphatase, and minerals. Kidney Int. 78:S10–S21.
  • Kassebaum NJ, Smith AGC, Bernabé E, Fleming TD, Reynolds AE, Vos T, Murray CJL, Marcenes W, Abyu GY, Alsharif U, et al. 2017. Global, regional, and national prevalence, incidence, and disability-adjusted life years for oral conditions for 195 countries, 1990–2015: a systematic analysis for the global burden of diseases, injuries, and risk factors. J Dent Res. 96:380–387.
  • Katz J, Chegini N, Shiverick KT, Lamont RJ. 2009. Localization of Porphyromonas gingivalis in preterm delivery placenta. J Dent Res. 88:575–578.
  • Kazancioglu R. 2013. Risk factors for chronic kidney disease: an update. Kidney Int Suppl (2011). 3:368–371.
  • Kesavalu L, Sathishkumar S, Bakthavatchalu V, Matthews C, Dawson D, Steffen M, Ebersole JL. 2007. Rat model of polymicrobial infection, immunity, and alveolar bone resorption in periodontal disease. Infect Immun. 75:1704–1712.
  • Kho HS, Lee SW, Chung SC, Kim YK. 1999. Oral manifestations and salivary flow rate, pH, and buffer capacity in patients with end-stage renal disease undergoing hemodialysis. Oral Surg Oral Med Oral Pathol Oral Radiol. 88:316–319.
  • Könönen E, Wade WG. 2015. Actinomyces and related organisms in human infections. Clin Microbiol Rev. 28:419–442.
  • Kumar M, Umashankar DN, Viswanath D, Girish G. 2013. Role of the oral microflora in health and disease. J Indian Acad Oral Med Radiol.25:184–187.
  • Levey AS, Coresh J, Balk E, Kausz AT, Levin A, Steffes MW, Hogg RJ, Perrone RD, Lau J, Eknoyan G, et al. 2003. National kidney foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann Intern Med. 139:137–147.
  • Li X, Kolltveit KM, Tronstad L, Olsen I. 2000. Systemic diseases caused by oral infection. Clin Microbiol Rev. 13:547–558.
  • Linden GJ, Linden K, Yarnell J, Evans A, Kee F, Patterson CC. 2012. All-cause mortality and periodontitis in 60–70-year-old men: a prospective cohort study. J Clin Periodontol. 39:940–946.
  • Listgarten MA. 1986. Pathogenesis of periodontitis. J Clin Periodontol. 13:418–430.
  • Loos BG. 2005. Systemic markers of inflammation in periodontitis. J Periodontol. 76:2106–2115.
  • Loos BG. 2006. Systemic effects of periodontitis. Int J Dental Hygiene. 4:34–38.
  • Lusco MA, Fogo AB, Najafian B, Alpers CE. 2016. AJKD Atlas of renal pathology: subacute bacterial endocarditis-associated glomerulonephritis. Am J Kidney Dis. 68:e11–e12.
  • Luyckx VA, Tuttle KR, Garcia-Garcia G, Gharbi MB, Heerspink HJL, Johnson DW, Liu ZH, Massy ZA, Moe O, Nelson RG, et al. 2017. Reducing major risk factors for chronic kidney disease. Kidney Int Suppl. 7:71–87.
  • Macuch PJ, Tanner AC. 2000. Campylobacter species in health, gingivitis, and periodontitis. J Dent Res. 79:785–792.
  • Majumdar A, Chowdhary S, Ferreira MA, Hammond LA, Howie AJ, Lipkin GW, Littler WA. 2000. Renal pathological findings in infective endocarditis. Nephrol Dial Transplant. 15:1782–1787.
  • Marsh PD. 1994. Microbial ecology of dental plaque and its significance in health and disease. Adv Dent Res. 8:263–271.
  • Marsh PD. 2000. Role of the oral microflora in health. Microb Ecol Health Dis. 12:130–137.
  • Marsh PD, Martin MV, Lewis MAO, Williams D. 2009. Oral microbiology E-Book. Elsevier Health Sciences. http://books.google.co.uk/books?id=EZeHhpjhDSgC&dq=oral+microb+marsh+2009&source=gbs_navlinks_s.
  • Meyer TW, Hostetter TH. 2007. Uremia. N Engl J Med. 357:1316–1325.
  • Miller WD. 1891. The human mouth as a focus of infection. Lancet. 138:340–342.
  • Mirrakhimov AE. 2012. Obstructive sleep apnea and kidney disease: is there any direct link? Sleep Breath. 16:1009–1016.
  • Mitch WE, Maroni BJ. 1999. Factors causing malnutrition in patients with chronic uremia. Am J Kidney Dis. 33:176–179.
  • Moutsopoulos NM, Madianos PN. 2006. Low-grade inflammation in chronic infectious diseases: paradigm of periodontal infections. Ann N Y Acad Sci. 1088:251–264.
  • Nasr SH, Fidler ME, Valeri AM, Cornell LD, Sethi S, Zoller A, Stokes MB, Markowitz GS, D'Agati VD. 2011. Postinfectious glomerulonephritis in the elderly. J Am Soc Nephrol. 22:187–195.
  • Nasr SH, Markowitz GS, Stokes MB, Said SM, Valeri AM, D'Agati VD. 2008. Acute postinfectious glomerulonephritis in the modern era: experience with 86 adults and review of the literature. Medicine. 87:21–32.
  • Niederman R, Brunkhorst B, Smith S, Weinreb RN, Ryder MI. 1990. Ammonia as a potential mediator of adult human periodontal infection: inhibition of neutrophil function. Arch Oral Biol. 35:205s–209s.
  • Nogueira A, Pires MJ, Oliveira PA. 2017. Pathophysiological mechanisms of renal fibrosis: a review of animal models and therapeutic strategies. In Vivo. 31:1–22.
  • Obando-Pereda G. 2018. Trojans in oral environments: evidence of molecular mimicry in oral immunity. In: Bhardwaj SB, editor. Oral microbiology in periodontitis. IntechOpen.
  • Oberg BP, McMenamin E, Lucas F, McMonagle E, Morrow J, Ikizler T, Himmelfarb J. 2004. Increased prevalence of oxidant stress and inflammation in patients with moderate to severe chronic kidney disease. Kidney Int. 65:1009–1016.
  • Ohkuni H, Friedman J, Van de Rijn I, Fischetti VA, Poon-King T, Zabriskie JB. 1983. Immunological studies of post-streptococcal sequelae: serological studies with an extracellular protein associated with nephritogenic streptococci. Clin Exp Immunol. 54:185–193.
  • Olsen I, Yamazaki K. 2019. Can oral bacteria affect the microbiome of the gut? J Oral Microbiol. 11:1586422.
  • Oyetola EO, Owotade FJ, Agbelusi GA, Fatusi OA, Sanusi AA. 2015. Oral findings in chronic kidney disease: implications for management in developing countries. BMC Oral Health. 15:24.
  • Padilla C, Lobos O, Hubert E, Gonzalez C, Matus S, Pereira M, Hasbun S, Descouvieres C. 2006. Periodontal pathogens in atheromatous plaques isolated from patients with chronic periodontitis. J Periodontal Res. 41:350–353.
  • Papapanou P, Sanz M, Buduneli N, Dietrich T, Feres M, Fine D, Flemmig T, Garcia R, Giannobile W, Graziani F. 2018. Periodontitis: consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Clin Periodontol. 45:S162–S170.
  • Paraskevas S, Huizinga JD, Loos BG. 2008. A systematic review and meta-analyses on C-reactive protein in relation to periodontitis. J Clin Periodontol. 35:277–290.
  • Payne M, Hashim A, Alsam A, Joseph S, Aduse-Opoku J, Wade W, Curtis M. 2019. Horizontal and vertical transfer of oral microbial dysbiosis and periodontal disease. J Dent Res. 98:1503–1510.
  • Peterson S, Woodhead J, Crall J. 1985. Caries resistance in children with chronic renal failure: plaque pH, salivary pH, and salivary composition. Pediatr Res. 19:796–799.
  • Pihlstrom BL, Michalowicz BS, Johnson NW. 2005. Periodontal diseases. Lancet. 366:1809–1820.
  • Pizzo G, Guiglia R, Russo LL, Campisi G. 2010. Dentistry and internal medicine: from the focal infection theory to the periodontal medicine concept. Eur J Intern Med. 21:496–502.
  • Porter SR, Scully C, Hegarty AM. 2004. An update of the etiology and management of xerostomia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 97:28–46.
  • Poveda-Roda R, Jimenez Y, Carbonell E, Gavalda C, Margaix-Munoz MM, Sarrión-Pérez G. 2008. Bacteremia originating in the oral cavity. A Review. Med Oral Patol Oral Cirugia Bucal. 13:E355–E362.
  • Pradeep AR, Kathariya R, Arjun Raju P, Sushma Rani R, Sharma A, Raghavendra NM. 2012. Risk factors for chronic kidney diseases may include periodontal diseases, as estimated by the correlations of plasma pentraxin-3 levels: a case-control study. Int Urol Nephrol. 44:829–839.
  • Preshaw P, Alba A, Herrera D, Jepsen S, Konstantinidis A, Makrilakis K, Taylor R. 2012. Periodontitis and diabetes: a two-way relationship. Diabetologia. 55:21–31.
  • Ramanathan G, Abeyaratne A, Sundaram M, Fernandes DK, Pawar B, Perry GJ, Sajiv C, Majoni SW. 2017. Analysis of clinical presentation, pathological spectra, treatment and outcomes of biopsy-proven acute postinfectious glomerulonephritis in adult indigenous people of the Northern Territory of Australia. Nephrology. 22:403–411.
  • Rams TE, Feik D, Mortensen JE, Degener JE, Winkelhoff AJ. 2014. Antibiotic susceptibility of periodontal Streptococcus constellatus and Streptococcus intermedius clinical isolates. J Periodontol. 85:1792–1798.
  • Rasiah IA, Wong L, Anderson SA, Sissons CH. 2005. Variation in bacterial DGGE patterns from human saliva: over time, between individuals and in corresponding dental plaque microcosms. Arch Oral Biol. 50:779–787.
  • Reali L, Zuliani E, Gabutti L, Schönholzer C, Marone C. 2009. Poor oral hygiene enhances gingival overgrowth caused by calcineurin inhibitors. J Clin Pharm Ther. 34:255–260.
  • Rijkschroeff P, Jansen IDC, Van der Weijden FA, Keijser BJF, Loos BG, Nicu EA. 2016. Oral polymorphonuclear neutrophil characteristics in relation to oral health: a cross-sectional, observational clinical study. Int J Oral Sci. 8:191–198.
  • Salgado-Pabon W, Breshears L, Spaulding AR, Merriman JA, Stach CS, Horswill AR, Peterson ML, Schlievert PM. 2013. Superantigens are critical for Staphylococcus aureus infective endocarditis, sepsis, and acute kidney injury. MBio. 4.
  • Scannapieco FA. 1998. Position paper of The American Academy of Periodontology: periodontal disease as a potential risk factor for systemic diseases. J Periodontol. 69:841–850.
  • Schatzle M, Loe H, Lang NP, Burgin W, Anerud A, Boysen H. 2004. The clinical course of chronic periodontitis. J Clin Periodontol. 31:1122–1127.
  • Scheld WM, Valone JA, Sande MA. 1978. Bacterial adherence in the pathogenesis of endocarditis. Interaction of bacterial dextran, platelets, and fibrin. J Clin Invest. 61:1394–1404.
  • Schellevis FG, Van der Velden J, Van de Lisdonk E, Van Eijk JTM, Van Weel C. 1993. Comorbidity of chronic diseases in general practice. J Clin Epidemiol. 46:469–473.
  • Sen S, Giamberardino LD, Moss K, Morelli T, Rosamond WD, Gottesman RF, Beck J, Offenbacher S. 2018. Periodontal disease, regular dental care use, and incident ischemic stroke. Stroke. 49:355–362.
  • Serra E, Silva Filho W, Casarin RC, Nicolela EL Jr, Passos HM, Sallum AW, Goncalves RB. 2014. Microbial diversity similarities in periodontal pockets and atheromatous plaques of cardiovascular disease patients. PLoS One. 9:e109761.
  • Settem RP, El-Hassan AT, Honma K, Stafford GP, Sharma A. 2012. Fusobacterium nucleatum and Tannerella forsythia induce synergistic alveolar bone loss in a mouse periodontitis model. Infect Immun. 80:2436–2443.
  • Seymour GJ, Ford PJ, Cullinan MP, Leishman S, Yamazaki K. 2007. Relationship between periodontal infections and systemic disease. Clin Microbiol Infect. 13:3–10.
  • Shaikh HFM, Patil SH, Pangam TS, Rathod KV. 2018. Polymicrobial synergy and dysbiosis: an overview. J Indian Soc Periodontol. 22:101–106.
  • Sharma P, Dietrich T, Ferro CJ, Cockwell P, Chapple ILC. 2016. Association between periodontitis and mortality in stages 3–5 chronic kidney disease: NHANES III and linked mortality study. J Clin Periodontol. 43:104–113.
  • Shi Y, Liu Z, Shen Y, Zhu H. 2018. A novel perspective linkage between kidney function and Alzheimer’s disease. Front Cell Neurosci. 12:384–384.
  • Simenhoff ML, Burke JF, Saukkonen JJ, Ordinario AT, Doty R, Dunn S. 1977. Biochemical profile of uremic breath. N Engl J Med. 297:132–135.
  • Slade GD, Ghezzi EM, Heiss G, Beck JD, Riche E, Offenbacher S. 2003. Relationship between periodontal disease and C-reactive protein among adults in the Atherosclerosis Risk in Communities study. Arch Intern Med. 163:1172–1179.
  • Smalley J. 1994. Pathogenic mechanisms in periodontal disease. Adv Dent Res. 8:320–328.
  • Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL. 1998. Microbial complexes in subgingival plaque. J Clin Periodontol. 25:134–144.
  • Somacarrera ML, Hernandez G, Acero J, Moskow BS. 1994. Factors related to the incidence and severity of cyclosporin-induced gingival overgrowth in transplant patients. A longitudinal study. J Periodontol. 65:671–675.
  • Stingu CS, Schaumann R, Jentsch H, Eschrich K, Brosteanu O, Rodloff AC. 2013. Association of periodontitis with increased colonization by Prevotella nigrescens. J Invest Clin Dent. 4:20–25.
  • Tada A, Hanada N. 2010. Opportunistic respiratory pathogens in the oral cavity of the elderly. FEMS Immunol Med Microbiol. 60:1–17.
  • Tanaka S, Yoshida M, Murakami Y, Ogiwara T, Shoji M, Kobayashi S, Watanabe S, Machino M, Fujisawa S. 2008. The relationship of Prevotella intermedia, Prevotella nigrescens and Prevotella melaninogenica in the supragingival plaque of children, caries and oral malodor. J Clin Pediatr Dent. 32:195–200.
  • Taylor JJ, Preshaw PM. 2016. Gingival crevicular fluid and saliva. Periodontol 2000. 70:7–10.
  • Thoden Van Velzen SK, Abraham-Inpijn L, Moorer WR. 1984. Plaque and systemic disease: a reappraisal of the focal infection concept. J Clin Periodontol. 11:209–220.
  • Tonelli M, Wiebe N, Guthrie B, James MT, Quan H, Fortin M, Klarenbach SW, Sargious P, Straus S, Lewanczuk R, et al. 2015. Comorbidity as a driver of adverse outcomes in people with chronic kidney disease. Kidney Int. 88:859–866.
  • Tonetti MS, D'Aiuto F, Nibali L, Donald A, Storry C, Parkar M, Suvan J, Hingorani AD, Vallance P, Deanfield J. 2007. Treatment of periodontitis and endothelial function. N Engl J Med. 356:911–920.
  • Trivedi M, Pasari A, Chowdhury A, Kurien A, Pandey R. 2017. The epidemiology, clinical features, and outcome of infection-related glomerulonephritis from East India: a single center experience. Indian J Nephrol. 27:307.
  • Usher AKH, Stockley RA. 2013. The link between chronic periodontitis and COPD: a common role for the neutrophil? BMC Med. 11:241.
  • Van Dyke TE, Sheilesh D. 2005. Risk factors for periodontitis. J Int Acad Periodontol. 7:3–7.
  • Vanholder R, De Smet R, Glorieux G, Argiles A, Baurmeister U, Brunet P, Clark W, Cohen G, De Deyn PP, Deppisch R, et al., 2003. Review on uremic toxins: classification, concentration, and interindividual variability. Kidney Int. 63:1934–1943.
  • Vaziri ND, Pahl MV, Crum A, Norris K. 2012. Effect of uremia on structure and function of immune system. J Ren Nutr. 22:149–156.
  • Vielkind P, Jentsch H, Eschrich K, Rodloff AC, Stingu CS. 2015. Prevalence of Actinomyces spp. in patients with chronic periodontitis. Int J Med Microbiol. 305:682–688.
  • Vila T, Rizk AM, Sultan AS, Jabra-Rizk MA. 2019. The power of saliva: antimicrobial and beyond. PLoS Pathog. 15:e1008058.
  • Vosti KL, Johnson RH, Dillon MF. 1971. Further characterization of purified fractions of M protein from a strain of group A, type 12 Streptococcus. J Immunol Res. 107:104–114.
  • Wade WG. 2013. The oral microbiome in health and disease. Pharmacol Res. 69:137–143.
  • Wahid A, Chaudhry S, Ehsan A, Butt S, Ali Khan A. 2013. Bidirectional relationship between chronic kidney disease & periodontal disease. Pak J Med Sci. 29:211–215.
  • Whitmore SE, Lamont RJ. 2011. The pathogenic persona of community associated oral streptococci. Mol Microbiol. 81:305–314.
  • Winning L, Patterson CC, Cullen KM, Stevenson KA, Lundy FT, Kee F, Linden GJ. 2015. The association between subgingival periodontal pathogens and systemic inflammation. J Clin Periodontol. 42:799–806.
  • Yamanaka T, Furukawa T, Matsumoto-Mashimo C, Yamane K, Sugimori C, Nambu T, Mori N, Nishikawa H, Walker CB, Leung KP, et al. 2009. Gene expression profile and pathogenicity of biofilm-forming Prevotella intermedia strain 17. BMC Microbiol. 9:11.
  • Yoshizawa N, Oshima S, Takeuchi A, Kondo S, Oda T, Shimizu J, Nishiyama J, Ishida A, Nakabayashi I, Tazawa K. 1997. Experimental acute glomerulonephritis induced in the rabbit with a specific streptococcal antigen. Clin Exp Immunol. 107:61–67.
  • Zabriskie JB, Lewshenia R, Möller G, Wehle B, Falk RE. 1970. Lymphocytic responses to streptococcal antigens in glomerulonephritic patients. Science. 168:1105–1108.
  • Zhang J, Jiang H, Sun M, Chen J. 2017. Association between periodontal disease and mortality in people with CKD: a meta-analysis of cohort studies. BMC Nephrol. 18:269.
  • Zhao D, Khawaja AT, Jin L, Li KY, Tonetti M, Pelekos G. 2018. The directional and non-directional associations of periodontitis with chronic kidney disease: a systematic review and meta-analysis of observational studies. J Periodont Res. 53:682–704.
  • Zijnge V, Van Leeuwen MBM, Degener JE, Abbas F, Thurnheer T, Gmür R, Harmsen HJ. 2010. Oral biofilm architecture on natural teeth. PLoS One. 5:e9321.
  • Zoellner H, Chapple CC, Hunter N. 2002. Microvasculature in gingivitis and chronic periodontitis: disruption of vascular networks with protracted inflammation. Microsc Res Techn. 56:15–31.

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