Nanosystems against candidiasis: a review of studies performed over the last two decades

References

• Abbood HAR, Mohammed BL, Aboid HA. 2020. In vitro antifungal efficacy of Saccharomyces cerevisiae mediated nanoparticle against resistant Candida albicans isolates. Indian J Forensic Med Toxicol. 14:666–671.
   Google Scholar
• Abed-Alwahed FR, Al-Baqi NJA. 2020. Effect of the silver nanoparticles on erg11expression in fluconazole-resistant Candida albicans isolates. Plant Arch. 20:616–620.
   Google Scholar
• Adhavan P, Kaur G, Princy A, Murugan R. 2017. Essential oil nanoemulsions of wild patchouli attenuate multi-drug resistant gram-positive, gram-negative and Candida albicans. Ind Crops Prod. 100:106–116.
   Web of Science ®Google Scholar
• Ahmad A, Wei Y, Syed F, Tahir K, Taj R, Khan AU, Hameed MU, Yuan Q. 2016. Amphotericin B-conjugated biogenic silver nanoparticles as an innovative strategy for fungal infections. Microb Pathog. 99:271–281.
   PubMed Web of Science ®Google Scholar
• Ahmad T, Wani IA, Lone IH, Ganguly A, Manzoor N, Ahmad A, Ahmed J, Al-Shihri AS. 2013. Antifungal activity of gold nanoparticles prepared by solvothermal method. Mater Res Bull. 48:12–20.
   Web of Science ®Google Scholar
• Akbar S, Anwar A, Ayish A, Elliott JM, Squires AM. 2017. Phytantriol based smart nano-carriers for drug delivery applications. Eur J Pharm Sci. 101:31–42.
   PubMed Web of Science ®Google Scholar
• Akhlaghi SP, Ribeiro IR, Boyd BJ, Loh W. 2016. Impact of preparation method and variables on the internal structure, morphology, and presence of liposomes in phytantriol-Pluronic® F127 cubosomes. Colloids Surfaces B Biointerfaces. 145:845–853.
   PubMed Web of Science ®Google Scholar
• Al-Bahrani RM, Majeed SMA, Owaid MN, Mohammed AB, Rheem DA. 2018. Phyto-fabrication, characteristics and anticandidal effects of silver nanoparticles from leaves of Ziziphus mauritiana Lam. Acta Pharm Sci. 56:85–92.
   Google Scholar
• Ali EM, Abdallah BM. 2020. Effective inhibition of candidiasis using an eco-friendly leaf extract of Calotropis-gigantean-mediated silver nanoparticles. Nanomaterials. 10:422.
   Web of Science ®Google Scholar
• Alimehr S, Shekari Ebrahim Abad H, Shahverdi A, Hashemi J, Zomorodian k, Moazeni M, Vosoghian S, Rezaie S. 2015. Comparison of difference between fluconazole and silver nanoparticles in antimicrobial effect on fluconazole-resistant Candida albicans strains. Arch Pediatr Infect Dis. 3:e21481.
   Web of Science ®Google Scholar
• Aljaeid BM, Hosny KM. 2016. Miconazole-loaded solid lipid nanoparticles: formulation and evaluation of a novel formula with high bioavailability and antifungal activity. Int J Nanomedicine. 11:441–447.
   PubMed Web of Science ®Google Scholar
• Al-Jamal WT, Kostarelos K. 2011. Liposomes: from a clinically established drug delivery system to a nanoparticle platform for theranostic nanomedicine. Acc Chem Res. 44:1094–1104.
   PubMed Web of Science ®Google Scholar
• Allen TM, Cullis PR. 2013. Liposomal drug delivery systems: From concept to clinical applications. Adv Drug Deliv Rev. 65:36–48.
   PubMed Web of Science ®Google Scholar
• Amaral AC, Saavedra PHV, Oliveira Souza AC, de Melo MT, Tedesco AC, Morais PC, Soares Felipe MS, Bocca AL. 2019. Miconazole loaded chitosan-based nanoparticles for local treatment of vulvovaginal candidiasis fungal infections. Colloids Surf B Biointerfaces. 174:409–415.
   PubMed Web of Science ®Google Scholar
• Anderson J, Cundiff L, Schnars B, Gao M, Mackenzie I, Soll DR. 1989. Hypha formation in the white-opaque transition of Candida albicans. Infect Immun. 57:458–467.
   PubMed Web of Science ®Google Scholar
• Anderson MR, Klink K, Cohrssen A. 2004. Evaluation of vaginal complaints. JAMA. 291:1368–1379.
   PubMed Web of Science ®Google Scholar
• Ansari Z, Miller D, Galor A. 2013. Current thoughts in fungal keratitis: diagnosis and treatment. Curr Fungal Infect Rep. 7:209–218.
   PubMedGoogle Scholar
• Anton N, Benoit JP, Saulnier P. 2008. Design and production of nanoparticles formulated from nano-emulsion templates – a review. J Control Release. 128:185–199.
   PubMed Web of Science ®Google Scholar
• Araujo VHS, da Silva PB, Szlachetka IO, da Silva SW, Fonseca-Santos B, Chorilli M, et al. 2020. The influence of NLC composition on curcumin loading under a physicochemical perspective and in vitro evaluation. Colloids Surfaces A Physicochem Eng Asp. 602:125070.
   Web of Science ®Google Scholar
• Ashour SM. 2014. Silver nanoparticles as antimicrobial agent from Kluyveromyces marxianus and Candida utilis. Int J Curr Microbiol Appl Sci. 3:384–396.
   Google Scholar
• Austin LA, Mackey MA, Dreaden EC, El-Sayed MA. 2014. The optical, photothermal, and facile surface chemical properties of gold and silver nanoparticles in biodiagnostics, therapy, and drug delivery. Arch Toxicol. 88:1391–1417.
   PubMed Web of Science ®Google Scholar
• Bachhav YG, Patravale VB. 2009. Microemulsion based vaginal gel of fluconazole: Formulation, in vitro and in vivo evaluation. Int J Pharm. 365:175–179.
   PubMed Web of Science ®Google Scholar
• Baldim I, Tonani L, von Zeska Kress MR, Pereira Oliveira W. 2019. Lippia sidoides essential oil encapsulated in lipid nanosystem as an anti-Candida agent. Ind Crops Prod. 127:73–81.
   Web of Science ®Google Scholar
• Battaglia L, Gallarate M. 2012. Lipid nanoparticles: state of the art, new preparation methods and challenges in drug delivery. Expert Opin Drug Deliv. 9:497–508.
   PubMed Web of Science ®Google Scholar
• Baygar T, Sarac N, Ugur A, Karaca IR. 2019. Antimicrobial characteristics and biocompatibility of the surgical sutures coated with biosynthesized silver nanoparticles. Bioorg Chem. 86:254–258.
   PubMed Web of Science ®Google Scholar
• Ben-Ami R. 2018. Treatment of invasive candidiasis: a narrative review. J Fungi (Basel). 4:97.
   Google Scholar
• Bernegossi J, Calixto G, Sanches P, Fontana C, Cilli E, Garrido S, Chorilli M. 2015. Peptide KSL-W-loaded mucoadhesive liquid crystalline vehicle as an alternative treatment for multispecies oral biofilm. Molecules. 21:37.
   Web of Science ®Google Scholar
• Betzler de Oliveira de Siqueira L, Matos A. P d S, Cardoso V. d S, Villanova JCO, Guimarães B. d C L R, dos Santos EP, Beatriz Vermelho A, Santos-Oliveira R, Ricci Junior E. 2019. Clove oil nanoemulsion showed potent inhibitory effect against Candida spp. Nanotechnology. 30:425101.
   PubMed Web of Science ®Google Scholar
• Bhalekar MR, Pokharkar V, Madgulkar A, Patil N, Patil N. 2009. Preparation and evaluation of miconazole nitrate-loaded solid lipid nanoparticles for topical delivery. AAPS PharmSciTech. 10:289–296.
   PubMed Web of Science ®Google Scholar
• Bitew A, Abebaw Y. 2018. Vulvovaginal candidiasis: species distribution of Candida and their antifungal susceptibility pattern. BMC Womens Health. 18:94.
   PubMed Web of Science ®Google Scholar
• Bongomin F, Gago S, Oladele RO, Denning DW. 2017. Global and multi-national prevalence of fungal diseases – estimate precision. JoF. 3:57.
   Google Scholar
• Bonifácio BV, da Silva PB, Aparecido dos Santos Ramos M, Maria Silveira Negri K, Maria Bauab T,  Chorilli M. 2014. Nanotechnology-based drug delivery systems and herbal medicines: a review. Int J Nanomed. 9(1):1–15.
   PubMedGoogle Scholar
• Bonifácio BV, Ramos M. A d S, da Silva PB, Negri KMS, de Oliveira Lopes É, de Souza LP, Vilegas W, Pavan FR, Chorilli M, Bauab TM. 2015. Nanostructured lipid system as a strategy to improve the anti-Candida albicans activity of Astronium sp. Int J Nanomedicine. 10:5081–5092.
   PubMed Web of Science ®Google Scholar
• Bonifácio BV, Vila TVM, Masiero IF, da Silva PB, da Silva IC, de Oliveira Lopes É. 2019. Antifungal activity of a hydroethanolic extract from Astronium urundeuva leaves against Candida albicans and Candida glabrata. Front Microbiol. 10:1–12.
   PubMed Web of Science ®Google Scholar
• Brust M, Walker M, Bethell D, Schiffrin DJ, Whyman R. 1994. Synthesis of thiol-derivatised gold nanoparticles in a two-phase liquid–liquid system. J Chem Soc Chem Commun. 801–802.
   Google Scholar
• Calvo NL, Sreekumar S, Svetaz LA, Lamas MC, Moerschbacher BM, Leonardi D. 2019. Design and characterization of chitosan nanoformulations for the delivery of antifungal agents. Int J Mol Sci. 20.
   Web of Science ®Google Scholar
• Calzavara-Pinton PG, Venturini M, Sala R. 2005. A comprehensive overview of photodynamic therapy in the treatment of superficial fungal infections of the skin. J Photochem Photobiol, B. 78:1–6.
   PubMed Web of Science ®Google Scholar
• Campos FF, Calpena Campmany AC, Delgado GR, Serrano OL, Naveros BC. 2012. Development and characterization of a novel nystatin-loaded nanoemulsion for the buccal treatment of candidosis: ultrastructural effects and release studies. J Pharm Sci. 101:3739–3752.
   PubMed Web of Science ®Google Scholar
• Carbone C, Fuochi V, Zielińska A, Musumeci T, Souto EB, Bonaccorso A, Puglia C, Petronio Petronio G, Furneri PM. 2020. Dual-drugs delivery in solid lipid nanoparticles for the treatment of Candida albicans mycosis. Colloids Surfaces B Biointerfaces. 186:110705.
   PubMed Web of Science ®Google Scholar
• Carbone C, Teixeira M. d C, Sousa M. d C, Martins-Gomes C, Silva AM, Souto EMB, Musumeci T. 2019. Clotrimazole-loaded mediterranean essential oils NLC: a synergic treatment of Candida skin infections. Pharmaceutics. 11:231.
   PubMed Web of Science ®Google Scholar
• Carvalho FC, Campos ML, Peccinini RG, Gremião MPD. 2013. Nasal administration of liquid crystal precursor mucoadhesive vehicle as an alternative antiretroviral therapy. Eur J Pharm Biopharm. 84:219–227.
   PubMed Web of Science ®Google Scholar
• Cassano R, Ferrarelli T, Mauro MV, Cavalcanti P, Picci N, Trombino S. 2016. Preparation, characterization and in vitro activities evaluation of solid lipid nanoparticles based on PEG-40 stearate for antifungal drugs vaginal delivery. Drug Deliv. 23:1047–1056.
   PubMed Web of Science ®Google Scholar
• Chaudhari MB, Desai PP, Patel PA, Patravale VB. 2016. Solid lipid nanoparticles of amphotericin B (AmbiOnp): in vitro and in vivo assessment towards safe and effective oral treatment module. Drug Deliv Transl Res. 6:354–364.
   PubMed Web of Science ®Google Scholar
• Chen Y, Wu Q, Zhang Z, Yuan L, Liu X, Zhou L. 2012. Preparation of curcumin-loaded liposomes and evaluation of their skin permeation and pharmacodynamics. Molecules. 17:5972–5987.
   PubMed Web of Science ®Google Scholar
• Choi H, Lee DG. 2015. Lycopene induces apoptosis in Candida albicans through reactive oxygen species production and mitochondrial dysfunction. Biochimie. 115:108–115.
   PubMed Web of Science ®Google Scholar
• Chong JYT, Mulet X, Boyd BJ, Drummond CJ. 2015. Steric stabilizers for cubic phase lyotropic liquid crystal nanodispersions (cubosomes). In: Advances in Planar Lipid Bilayers and Liposomes. p. 131–187.
   Google Scholar
• Chorilli M, Calixto G, Rimério TC, Scarpa MV. 2013. Caffeine encapsulated in small unilamellar liposomes: characerization and in vitro release profile. J Dispers Sci Technol. 34:1465–1470.
   Web of Science ®Google Scholar
• Chorilli M, Prestes PS, Rigon RB, Leonardi GR, Chiavacci LA, Scarpa MV. 2009. Development of liquid-crystalline systems using silicon glycol copolymer and polyether functional siloxane. Quím Nova. 32:1036–1040.
   Web of Science ®Google Scholar
• D’Cruz OJ, Yiv SH, Waurzyniak B, Uckun FM. 2001. Contraceptive efficacy and safety studies of a novel microemulsion-based lipophilic vaginal spermicide. Fertil Steril. 75:115–124.
   PubMed Web of Science ®Google Scholar
• da Silva Gündel S, Velho MC, Diefenthaler MK, Favarin FR, Copetti PM, de Oliveira Fogaça A, et al. 2018. Basil oil-nanoemulsions: development, cytotoxicity and evaluation of antioxidant and antimicrobial potential. J Drug Deliv Sci Technol. 46:378–383.
   Web of Science ®Google Scholar
• da Silva PB, dos Santos Ramos MA, Bonifácio BV, Negri KMS, Sato MR, Bauab TM, Chorilli M. 2014. Nanotechnological strategies for vaginal administration of drugs – a review. J Biomed Nanotechnol. 10:2218–2243.
   PubMed Web of Science ®Google Scholar
• Daraee H, Etemadi A, Kouhi M, Alimirzalu S, Akbarzadeh A. 2016. Application of liposomes in medicine and drug delivery. Artif Cells Nanomed Biotechnol. 44:381–391.
   PubMed Web of Science ®Google Scholar
• de Alcântara Sica de Toledo L, Rosseto HC, dos Santos RS, Spizzo F, Del Bianco L, Montanha MC, Esposito E, Kimura E, Bonfim-Mendonça P. d S, Svidzinski TIE, et al. 2018. Thermal magnetic field activated propolis release from liquid crystalline system based on magnetic nanoparticles. AAPS PharmSciTech. 19:3258–3271.
   PubMed Web of Science ®Google Scholar
• de Bastiani F. d S, Spadari C de C, de Matos JKR, Salata GC, Lopes LB, Ishida K. 2020. Nanocarriers provide sustained antifungal activity for amphotericin B and miltefosine in the topical treatment of murine vaginal candidiasis. Front Microbiol. 10:2976.
   PubMed Web of Science ®Google Scholar
• De Campos VEB, Cerqueira-Coutinho CS, Capella FNC, Soares BG, Holandino C, Mansur CRE. 2017. Development and in vitro assessment of nanoemulsion for delivery of ketoconazole against Candida albicans. J Nanosci Nanotechnol. 17:4623–4630.
   Web of Science ®Google Scholar
• de Lima JA, Paines TC, Motta MH, Weber WB, dos Santos SS, Cruz L, da Silva C. d B. 2017. Novel Pemulen/Pullulan blended hydrogel containing clotrimazole-loaded cationic nanocapsules: evaluation of mucoadhesion and vaginal permeation. Mater Sci Eng C. 79:886–893.
   PubMed Web of Science ®Google Scholar
• Deshpande PP, Biswas S, Torchilin VP. 2013. Current trends in the use of liposomes for tumor targeting. Nanomedicine (Lond). 8:1509–1528.
   PubMed Web of Science ®Google Scholar
• Doktorovova S, Souto EB, Silva AM. 2014. Nanotoxicology applied to solid lipid nanoparticles and nanostructured lipid carriers – a systematic review of in vitro data. Eur J Pharm Biopharm. 87:1–18.
   PubMed Web of Science ®Google Scholar
• Domingues Bianchin M, Borowicz SM, da Rosa Monte Machado G, Pippi B, Stanisçuaski Guterres S, Raffin Pohlmann A, Meneghello Fuentefria A, Clemes Külkamp-Guerreiro I. 2019. Lipid core nanoparticles as a broad strategy to reverse fluconazole resistance in multiple Candida species. Colloids Surfaces B Biointerfaces. 175:523–529.
   PubMed Web of Science ®Google Scholar
• dos Santos MK, Kreutz T, Danielli LJ, De Marchi JGB, Pippi B, Koester LS, et al. 2020. A chitosan hydrogel-thickened nanoemulsion containing Pelargonium graveolens essential oil for treatment of vaginal candidiasis. J Drug Deliv Sci Technol. 56:101527.
   Web of Science ®Google Scholar
• dos Santos Ramos MA, Calixto G, de Toledo LG, Bonifácio BV, do Ssantos LC, de Almeida MTG, et al. 2015. Liquid crystal precursor mucoadhesive system as a strategy to improve the prophylactic action of Syngonanthus nitens (Bong.) Ruhland against infection by Candida krusei. Int J Nanomedicine. 10:7455–7466.
   PubMed Web of Science ®Google Scholar
• Dos Santos Ramos MA, Da Silva P, Spósito L, De Toledo L, Bonifácio B, Rodero CF, Dos Santos K, Chorilli M, Bauab TM. 2018. Nanotechnology-based drug delivery systems for control of microbial biofilms: a review. IJN. 13:1179–1213.
   Google Scholar
• dos Santos Ramos MA, de Toledo LG, Fioramonti Calixto GM, Bonifácio BV, de Freitas Araújo MG, dos Santos LC, et al. 2016. Syngonanthus nitens Bong. (Rhul.)-loaded nanostructured system for Vulvovaginal candidiasis treatment. Int J Mol Sci. 17:1368.
   Web of Science ®Google Scholar
• Durán N, Marcato PD, De Conti R, Alves OL, Costa F, Brocchi M. 2010. Potential use of silver nanoparticles on pathogenic bacteria, their toxicity and possible mechanisms of action. J Braz Chem Soc. 21:949–959.
   Web of Science ®Google Scholar
• Ebersold MM, Petrović M, Fong WK, Bonvin D, Hofmann H, Milošević I. 2018. Hexosomes with undecylenic acid efficient against Candida albicans. Nanomaterials. 8:91.
   Web of Science ®Google Scholar
• El Rabey HA, Almutairi FM, Alalawy AI, Al-Duais MA, Sakran MI, Zidan NS, Tayel AA. 2019. Augmented control of drug-resistant Candida spp. via fluconazole loading into fungal chitosan nanoparticles. Int J Biol Macromol. 141:511–516.
   PubMed Web of Science ®Google Scholar
• Elmataeeshy ME, Sokar MS, Bahey-El-Din M, Shaker DS. 2018. Enhanced transdermal permeability of terbinafine through novel nanoemulgel formulation; development, in vitro and in vivo characterization. Futur J Pharm Sci. 4:18–28.
   Web of Science ®Google Scholar
• El-Sheridy NA, Ramadan AA, Eid AA, El-Khordagui LK. 2019. Itraconazole lipid nanocapsules gel for dermatological applications: in vitro characteristics and treatment of induced cutaneous candidiasis. Colloids Surfaces B Biointerfaces. 181:623–631.
   PubMed Web of Science ®Google Scholar
• Esposito E, Ravani L, Contado C, Costenaro A, Drechsler M, Rossi D, et al. 2013. Clotrimazole nanoparticle gel for mucosal administration. Mater Sci Eng C. 33:411–418.
   PubMed Web of Science ®Google Scholar
• Fang J, Huang B, Ding Z. 2020. Efficacy of antifungal drugs in the treatment of oral candidiasis: a  Bayesian network meta-analysis. J Prosthet Dent. DOI:10.1016/j.prosdent.2019.12.025.
   PubMed Web of Science ®Google Scholar
• Faraday MX. 1857. The Bakerian Lecture. – experimental relations of gold (and other metals) to light. Philos Trans R Soc London. 147:145–181.
   Google Scholar
• Farokhzad OC. 2008. Nanotechnology for drug delivery: the perfect partnership. Expert Opin Drug Deliv. 5:927–929.
   PubMed Web of Science ®Google Scholar
• Farrag Y, Ide W, Montero B, Rico M, Rodríguez-Llamazares S, Barral L, Bouza R. 2018. Preparation of starch nanoparticles loaded with quercetin using nanoprecipitation technique. Int J Biol Macromol. 114:426–433.
   PubMed Web of Science ®Google Scholar
• Fernandes Costa A, Evangelista Araujo D, Santos Cabral M, Teles Brito I, Borges de Menezes Leite L, Pereira M, Correa Amaral A. 2019. Development, characterization, and in vitro-in vivo evaluation of polymeric nanoparticles containing miconazole and farnesol for treatment of vulvovaginal candidiasis. Med Mycol. 57:52–62.
   PubMed Web of Science ®Google Scholar
• Fernández-Campos F, Clares Naveros B, López Serrano O, Alonso Merino C, Calpena Campmany AC. 2013. Evaluation of novel nystatin nanoemulsion for skin candidosis infections. Mycoses. 56:70–81.
   PubMed Web of Science ®Google Scholar
• Fonseca-Santos B, Bonifácio BV, Baub TM, Gremião MPD, Chorilli M. 2019. In-situ gelling liquid crystal mucoadhesive vehicle for curcumin buccal administration and its potential application in the treatment of oral candidiasis. J Biomed Nanotechnol. 15:1334–1344.
   PubMed Web of Science ®Google Scholar
• Fonseca-Santos B, Chorilli M. 2018. An overview of polymeric dosage forms in buccal drug delivery: State of art, design of formulations and their in vivo performance evaluation. Mater Sci Eng, C. 86:129–143.
   PubMed Web of Science ®Google Scholar
• Fonseca-Santos B, Satake CY, Calixto GMF, Dos Ssantos AM, Chorilli M. 2017. Trans-resveratrol-loaded nonionic lamellar liquid-crystalline systems: Structural, rheological, mechanical, textural, and bioadhesive characterization and evaluation of in vivo anti-inflammatory activity. Int J Nanomedicine. 12:6883–6893.
   PubMed Web of Science ®Google Scholar
• Füredi P, Pápay ZE, Kovács K, Kiss BD, Ludányi K, Antal I, Klebovich I. 2017. Development and characterization of the voriconazole loaded lipid-based nanoparticles. J Pharm Biomed Anal. 132:184–189.
   PubMed Web of Science ®Google Scholar
• Garcês A, Amaral MH, Lobo JMS, Silva AC. 2018. Formulations based on solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for cutaneous use: a review. Eur J Pharm Sci. 112:159–167.
   PubMed Web of Science ®Google Scholar
• Garg A, Singh S. 2014. Targeting of eugenol-loaded solid lipid nanoparticles to the epidermal layer of human skin. Nanomedicine (Lond). 9:1223–1238.
   PubMed Web of Science ®Google Scholar
• Gharieh A, Khoee S, Mahdavian AR. 2019. Emulsion and miniemulsion techniques in preparation of polymer nanoparticles with versatile characteristics. Adv Colloid Interface Sci. 269:152–186.
   PubMed Web of Science ®Google Scholar
• Ghosh P, Han G, De M, Kim CK, Rotello VM. 2008. Gold nanoparticles in delivery applications. Adv Drug Deliv Rev. 60:1307–1315.
   PubMed Web of Science ®Google Scholar
• Gibaud S, Attivi D. 2012. Microemulsions for oral administration and their therapeutic applications. Expert Opin Drug Deliv. 9:937–951.
   PubMed Web of Science ®Google Scholar
• Giongo JL, de Almeida Vaucher R, Fausto VP, Quatrin PM, Lopes LQS, Santos RCV, et al. 2016. Anti-Candida activity assessment of Pelargonium graveolens oil free and nanoemulsion in biofilm formation in hospital medical supplies. Microb Pathog. 100:170–178.
   PubMed Web of Science ®Google Scholar
• Giordani B, Basnet P, Mishchenko E, Luppi B, Škalko-Basnet N. 2019. Utilizing liposomal quercetin and gallic acid in localized treatment of vaginal Candida infections. Pharmaceutics. 12:9–21.
   Web of Science ®Google Scholar
• Gonçalves B, Ferreira C, Alves CT, Henriques M, Azeredo J, Silva S. 2016. Vulvovaginal candidiasis: epidemiology, microbiology and risk factors. Crit Rev Microbiol. 42:905–927.
   PubMed Web of Science ®Google Scholar
• Gondim BLC, Castellano LRC, de Castro RD, Machado G, Carlo HL, Valença AMG, de Carvalho FG. 2018. Effect of chitosan nanoparticles on the inhibition of Candida spp. biofilm on denture base surface. Arch Oral Biol. 94:99–107.
   PubMed Web of Science ®Google Scholar
• Gonzalez-Lara MF, Ostrosky-Zeichner L. 2020. Invasive candidiasis. Semin Respir Crit Care Med. 41:3–12.
   PubMed Web of Science ®Google Scholar
• Gordillo-Galeano A, Mora-Huertas CE. 2018. Solid lipid nanoparticles and nanostructured lipid carriers: a review emphasizing on particle structure and drug release. Eur J Pharm Biopharm. 133:285–308.
   PubMed Web of Science ®Google Scholar
• Gortzi O, Lala S, Chinou I, Tsaknis J. 2007. Evaluation of the antimicrobial and antioxidant activities of Origanum dictamnus extracts before and after encapsulation in liposomes. Molecules. 12:932–945.
   PubMed Web of Science ®Google Scholar
• Guinea J. 2014. Global trends in the distribution of Candida species causing candidemia. Clin Microbiol Infect. 20:5–10.
   Web of Science ®Google Scholar
• Guo C, Wang J, Cao F, Lee RJ, Zhai G. 2010. Lyotropic liquid crystal systems in drug delivery. Drug Discov Today. 15:1032–1040.
   PubMed Web of Science ®Google Scholar
• Gupta M, Tiwari S, Vyas SP. 2013. Influence of various lipid core on characteristics of SLNs designed for topical delivery of fluconazole against cutaneous candidiasis. Pharm Dev Technol. 18:550–559.
   PubMed Web of Science ®Google Scholar
• Gupta M, Vyas SP. 2012. Development, characterization and in vivo assessment of effective lipidic nanoparticles for dermal delivery of fluconazole against cutaneous candidiasis. Chem Phys Lipids. 165:454–461.
   PubMed Web of Science ®Google Scholar
• Hajar AA, Dakhili M, Saghazadeh M, Aghaei S, Nazari R. 2020. Synergistic antifungal effect of fluconazole combined with ZnO nanoparticles against Candida albicans strains from vaginal candidiasis. Med Lab J. 14:26–32.
   Google Scholar
• Hajjar FHE, Jebali A, Hekmatimoghaddam S. 2015. The inhibition of Candida albicans secreted aspartyl proteinase by triangular gold nanoparticles. Nanomed J. 2(1):54–59.
   Google Scholar
• Halwani M, Yebio B, Suntres ZE, Alipour M, Azghani AO, Omri A. 2008. Co-encapsulation of gallium with gentamicin in liposomes enhances antimicrobial activity of gentamicin against Pseudomonas aeruginosa. J Antimicrob Chemother. 62:1291–1297.
   PubMed Web of Science ®Google Scholar
• Hani U, Shivakumar H, Vaghela R, M. Osmani R, Shrivastava A. 2015. Candidiasis: a fungal infection – current challenges and progress in prevention and treatment. Infect Disord Drug Targets. 15:42–52.
   PubMedGoogle Scholar
• Harriott MM, Noverr MC. 2009. Candida albicans and Staphylococcus aureus form polymicrobial biofilms: effects on antimicrobial resistance. Antimicrob Agents Chemother. 53:3914–3922.
   PubMed Web of Science ®Google Scholar
• Hazzah HA, Farid RM, Nasra MMA, Hazzah WA, El-Massik MA, Abdallah OY. 2015. Gelucire-based nanoparticles for curcumin targeting to oral mucosa: preparation, characterization, and antimicrobial activity assessment. J Pharm Sci. 104:3913–3924.
   PubMed Web of Science ®Google Scholar
• Hellstein JW, Marek CL. 2019. Candidiasis: red and white manifestations in the oral cavity. Head Neck Pathol. 13:25–32.
   PubMed Web of Science ®Google Scholar
• Heurtault B, Saulnier P, Pech B, Proust JE, Richard J, Benoit JP. 2000. Lipid nanocapsules: preparation process and use as drug delivery systems. WO02688000.
   Google Scholar
• Hirlekar R, Jain S, Patel M, Garse H, Kadam V. 2010. Hexosomes: a novel drug delivery system. CDD. 7:28–35.
   PubMedGoogle Scholar
• Hosny KM, Aldawsari HM, Bahmdan RH, Sindi AM, Kurakula M, Alrobaian MM, Aldryhim AY, Alkhalidi HM, Bahmdan HH, Khallaf RA, et al. 2019. Preparation, optimization, and evaluation of hyaluronic acid-based hydrogel loaded with miconazole self-nanoemulsion for the treatment of oral thrush. AAPS PharmSciTech. 20:297.
   PubMed Web of Science ®Google Scholar
• Hosseini SS, Joshaghani H, Shokohi T, Ahmadi A, Mehrbakhsh Z. 2020. Antifungal activity of ZnO nanoparticles and nystatin and downregulation of SAP1-3 genes expression in fluconazole-resistant Candida albicans isolates from vulvovaginal candidiasis. Infect Drug Resist. 13:385–394.
   PubMed Web of Science ®Google Scholar
• Huang Y, Gui S. 2018. Factors affecting the structure of lyotropic liquid crystals and the correlation between structure and drug diffusion. RSC Adv. 8:6978–6987.
   PubMed Web of Science ®Google Scholar
• Hussain A, Singh VK, Singh OP, Shafaat K, Kumar S, Ahmad FJ. 2016. Formulation and optimization of nanoemulsion using antifungal lipid and surfactant for accentuated topical delivery of Amphotericin B. Drug Deliv. 23:3101–3110.
   PubMed Web of Science ®Google Scholar
• Hussein A, Abdel-Mottaleb MA, El-Assal M, Sammour O. 2020. Novel biocompatible essential oil-based lipid nanocapsules with antifungal properties. J Drug Deliv Sci Technol. 56:101605.
   Web of Science ®Google Scholar
• Huynh NT, Passirani C, Saulnier P, Benoit JP. 2009. Lipid nanocapsules: a new platform for nanomedicine. Int J Pharm. 379:201–209.
   PubMed Web of Science ®Google Scholar
• Iqbal MA, Md S, Sahni JK, Baboota S, Dang S, Ali J. 2012. Nanostructured lipid carriers system: recent advances in drug delivery. J Drug Target. 20:813–830.
   PubMed Web of Science ®Google Scholar
• Iravani S. 2011. Green synthesis of metal nanoparticles using plants. Green Chem. 13:2638–2650.
   Web of Science ®Google Scholar
• Jain S, Jain S, Khare P, Gulbake A, Bansal D, Jain SK. 2010. Design and development of solid lipid nanoparticles for topical delivery of an anti-fungal agent. Drug Deliv. 17:443–451.
   PubMed Web of Science ®Google Scholar
• Jaromin A, Zarnowski R, Piętka-Ottlik M, Andes DR, Gubernator J. 2018. Topical delivery of ebselen encapsulated in biopolymeric nanocapsules: drug repurposing enhanced antifungal activity. Nanomedicine (Lond). 13:1139–1155.
   PubMed Web of Science ®Google Scholar
• Jeffery-Smith A, Taori SK, Schelenz S, Jeffery K, Johnson EM, Borman A, et al. 2018. Candida auris: a review of the literature. Clin Microbiol Rev. 31:1–18.
   Web of Science ®Google Scholar
• Johal HS, Garg T, Rath G, Goyal AK. 2016. Advanced topical drug delivery system for the management of vaginal candidiasis. Drug Deliv. 23:550–563.
   PubMed Web of Science ®Google Scholar
• Johnson EM, Warnock DW, Luker J, Porter SR, Scully C. 1995. Emergence of azole drug resistance in Candida species from HIV-infected patients receivingprolonged fluconazole therapy for oral candidosis. J Antimicrob Chemother. 35:103–114.
   PubMed Web of Science ®Google Scholar
• Kaewbanjong J, Wan Sia Heng P, Boonme P. 2017. Clotrimazole microemulsion and microemulsion-based gel: evaluation of buccal drug delivery and irritancy using chick chorioallantoic membrane as the model. J Pharm Pharmacol. 69:1716–1723.
   PubMed Web of Science ®Google Scholar
• Kalkanci A, Ozdek S. 2011. Ocular fungal infections. Curr Eye Res. 36:179–189.
   PubMed Web of Science ®Google Scholar
• Kamaly N, Xiao Z, Valencia PM, Radovic-Moreno AF, Farokhzad OC. 2012. Targeted polymeric therapeutic nanoparticles: design, development and clinical translation. Chem Soc Rev. 41:2971–3010.
   PubMed Web of Science ®Google Scholar
• Kamat PV. 2002. Photophysical, photochemical and photocatalytic aspects of metal nanoparticles. J Phys Chem B. 106, 7729–7744.
   Web of Science ®Google Scholar
• Karimi N, Ghanbarzadeh B, Hamishehkar H, Mehramuz B, Kafil HS. 2018. Antioxidant, antimicrobial and physicochemical properties of turmeric extract-loaded nanostructured lipid carrier (NLC). Colloids Interface Sci Commun. 22:18–24.
   Web of Science ®Google Scholar
• Karmali PP, Chaudhuri A. 2007. Cationic liposomes as non-viral carriers of gene medicines: resolved issues, open questions, and future promises. Med Res Rev. 27:696–722.
   PubMed Web of Science ®Google Scholar
• Kaur G, Mehta SK. 2017. Developments of Polysorbate (Tween) based microemulsions: Preclinical drug delivery, toxicity and antimicrobial applications. Int J Pharm. 529:134–160.
   PubMedGoogle Scholar
• Kelidari HR, Moazeni M, Babaei R, Saeedi M, Akbari J, Parkoohi PI, Nabili M, Gohar AA, Morteza-Semnani K, Nokhodchi A. 2017. Improved yeast delivery of fluconazole with a nanostructured lipid carrier system. Biomed Pharmacother. 89:83–88.
   PubMed Web of Science ®Google Scholar
• Kenechukwu FC, Attama AA, Ibezim EC. 2017. Novel solidified reverse micellar solution-based mucoadhesive nano lipid gels encapsulating miconazole nitrate-loaded nanoparticles for improved treatment of oropharyngeal candidiasis. J Microencapsul. 34:592–609.
   PubMed Web of Science ®Google Scholar
• Khan MA, Aljarbou AN, Khan A, Younus H. 2015. Liposomal thymoquinone effectively combats fluconazole-resistant Candida albicans in a murine model. Int J Biol Macromol. 76:203–208.
   PubMed Web of Science ®Google Scholar
• Khan MF, Hameedullah M, Ansari AH, Ahmad E, Lohani MB, Khan RH, et al. 2014. Flower-shaped ZnO nanoparticles synthesized by a novel approach at near-room temperatures with antibacterial and antifungal properties. Int J Nanomedicine. 9:853.
   PubMed Web of Science ®Google Scholar
• Khan SN, Khan S, Iqbal J, Khan R, Khan AU. 2017. Enhanced killing and antibiofilm activity of encapsulated cinnamaldehyde against Candida albicans. Front Microbiol. 8:1–15.
   PubMed Web of Science ®Google Scholar
• Khare A, Singh I, Pawar P, Grover K. 2016. Design and evaluation of voriconazole loaded solid lipid nanoparticles for ophthalmic application. J Drug Deliv. 2016:1–11.
   Web of Science ®Google Scholar
• Kim DH, Jahn A, Cho SJ, Kim JS, Ki MH, Kim DD. 2015. Lyotropic liquid crystal systems in drug delivery: a review. J Pharm Investig. 45:1–11.
   Google Scholar
• Kischkel B, de Castilho PF, de Oliveira KMP, Rezende PST, Bruschi ML, Svidzinski TIE, Negri M. 2020. Silver nanoparticles stabilized with propolis show reduced toxicity and potential activity against fungal infections. Future Microbiol. 15:521–539.
   PubMed Web of Science ®Google Scholar
• Kleine-Brueggeney H, Zorzi GK, Fecker T, El Gueddari NE, Moerschbacher BM, Goycoolea FM. 2015. A rational approach towards the design of chitosan-based nanoparticles obtained by ionotropic gelation. Colloids Surf B Biointerfaces. 135:99–108.
   PubMed Web of Science ®Google Scholar
• Kong FY, Zhang JW, Li RF, Wang ZX, Wang WJ, Wang W. 2017. Unique roles of gold nanoparticles in drug delivery, targeting and imaging applications. Molecules. 22:1445.
   PubMed Web of Science ®Google Scholar
• Koopmans RJ, Aggeli A. 2010. Nanobiotechnology - quo vadis? Curr Opin Microbiol. 13:327–334.
   PubMed Web of Science ®Google Scholar
• Kumar L, Verma S, Vaidya B. 2017. Liposomes for the delivery of streptokinase. Ther Deliv. 8:855–865.
   PubMed Web of Science ®Google Scholar
• Kumar M, Varshney L, Francis S. 2005. Radiolytic formation of Ag clusters in aqueous polyvinyl alcohol solution and hydrogel matrix. Radiat Phys Chem. 73:21–27.
   Web of Science ®Google Scholar
• Kumar P, Ramteke PW, Pandey AC, Pandey H. 2019. Evaluation of antifungal activity of blended cinnamon oil and usnic acid nanoemulsion using candidiasis and dermatophytosis models. Biocatal Agric Biotechnol. 18:101062.
   Web of Science ®Google Scholar
• Kumararaja G, Saneesha PN, Kumar SS, Parveen VVS, Rahim SFA, Shamna KV, Shamna PA, Sundaraganapathy R, Gayathri R. 2019. Development and characterization of silver nanoparticles (AgNPs) using aqueous leaves broth of Artemisia vulgaris L., and its anti-fungal activity. Res J Pharm Technol. 12:4822–4826.
   Google Scholar
• Lakshmi N, Yalavarthi P, Vadlamudi H, Thanniru J, Yaga G, Haritha K. 2014. Cubosomes as targeted drug delivery systems – a biopharmaceutical approach. Curr Drug Discov Technol. 11:181–188.
   PubMedGoogle Scholar
• Lawrence MJ, Rees GD. 2012. Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev. 64:175–193.
   Web of Science ®Google Scholar
• Lewis MAO, Williams DW. 2017. Diagnosis and management of oral candidosis. Br Dent J. 223:675–681.
   PubMed Web of Science ®Google Scholar
• Li M, Zhu L, Liu B, Du L, Jia X, Han L, et al. 2016. Tea tree oil nanoemulsions for inhalation therapies of bacterial and fungal pneumonia. Colloids Surfaces B Biointerfaces. 141:408–416.
   PubMed Web of Science ®Google Scholar
• Li Y, Song J, Tian N, Cai J, Huang M, Xing Q, et al. 2014. Improving oral bioavailability of metformin hydrochloride using water-in-oil microemulsions and analysis of phase behavior after dilution. Int J Pharm. 473:316–325.
   PubMed Web of Science ®Google Scholar
• Lidich N, Aserin A, Garti N. 2016. Structural characteristics of oil-poor dilutable fish oil omega-3 microemulsions for ophthalmic applications. J Colloid Interface Sci. 463:83–92.
   PubMed Web of Science ®Google Scholar
• Lila ASA, Ishida T. 2017. Liposomal delivery systems: design optimization and current applications. Biol Pharm Bull. 40:1–10.
   PubMed Web of Science ®Google Scholar
• Ling JTS, Roberts CJ, Billa N. 2019. Antifungal and mucoadhesive properties of an orally administered chitosan-coated amphotericin B nanostructured lipid carrier (NLC). AAPS PharmSciTech. 20:1–11.
   Web of Science ®Google Scholar
• Lombardo D, Kiselev MA, Caccamo MT. 2019. Smart nanoparticles for drug delivery application: development of versatile nanocarrier platforms in biotechnology and nanomedicine. J Nanomater. 2019:1–26.
   Web of Science ®Google Scholar
• Lopez-Berestein G, Bodey GP, Frankel LS, Mehta K. 1987. Treatment of hepatosplenic candidiasis with liposomal-amphotericin B. J Clin Oncol. 5:310–317.
   PubMed Web of Science ®Google Scholar
• Lopez-Berestein G, Hopfer RL, Mehta R, Mehta K, Hersh EM, Juliano RL. 1984. Liposome-encapsulated amphotericin B for treatment of disseminated candidiasis in neutropenic mice. J Infect Dis. 150:278–283.
   PubMed Web of Science ®Google Scholar
• López-Lorente ÁI, Cárdenas S, González-Sánchez ZI. 2019. Effect of synthesis, purification and growth determination methods on the antibacterial and antifungal activity of gold nanoparticles. Mater Sci Eng C. 103:109805.
   PubMed Web of Science ®Google Scholar
• Lu XY, Wu DC, Li ZJ, Chen GQ. 2011. Polymer nanoparticles. In: Ilieva M, Lau WK-W, editors. Progress in molecular biology and translational science. 1st ed. Vol. 104. New York (NY): Elsevier; p. 299–323.
   Google Scholar
• Lucena PA, Nascimento TL, Gaeti MPN, de Ávila RI, Mendes LP, Vieira MS, Fabrini D, Amaral AC, Lima EM. 2018. In vivo vaginal fungal load reduction after treatment with itraconazole-loaded polycaprolactone-nanoparticles. J Biomed Nanotechnol. 14:1347–1358.
   PubMed Web of Science ®Google Scholar
• Ludwig DB, de Camargo LEA, Khalil NM, Auler ME, Mainardes RM. 2018. Antifungal activity of chitosan-coated poly(lactic-co-glycolic) acid nanoparticles containing amphotericin B. Mycopathologia. 183:659–668.
   PubMed Web of Science ®Google Scholar
• Luo Y, Liu Z, Zhang X, Huang J, Yu X, Li J, Xiong D, Sun X, Zhong Z. 2016. Effect of a controlled-release drug delivery system made of oleanolic acid formulated into multivesicular liposomes on hepatocellular carcinoma in vitro and in vivo. Int J Nanomedicine. 11:3111–3129.
   PubMed Web of Science ®Google Scholar
• Mahtab A, Anwar M, Mallick N, Naz Z, Jain GK, Ahmad FJ. 2016. Transungual delivery of ketoconazole nanoemulgel for the effective management of onychomycosis. AAPS PharmSciTech. 17:1477–1490.
   PubMed Web of Science ®Google Scholar
• Malmsten M. 2007. Phase transformations in self-assembly systems for drug delivery applications. J Dispersion Sci Technol. 28:63–72.
   Web of Science ®Google Scholar
• Manzano M, Vallet-Regí M. 2020. Mesoporous silica nanoparticles for drug delivery. Adv Funct Mater. 30:1902634.
   Web of Science ®Google Scholar
• Maroof A, Farazuddin M, Owais M. 2010. Potential use of liposomal diallyl sulfide in the treatment of experimental murine candidiasis. Biosci Rep. 30:223–231.
   PubMed Web of Science ®Google Scholar
• Mas N, Galiana I, Hurtado S, Mondragón L, Bernardos A, Sancenón F, et al. 2014. Enhanced antifungal efficacy of tebuconazole using gated pH-driven mesoporous nanoparticles. Int J Nanomedicine. 9:2597–2606.
   PubMed Web of Science ®Google Scholar
• Mathur M, Devi VK. 2017. Potential of novel drug delivery systems in the management of topical candidiasis. J Drug Target. 25:685–703.
   PubMed Web of Science ®Google Scholar
• McClements DJ. 2011. Edible nanoemulsions: fabrication, properties, and functional performance. Soft Matter. 7:2297–2316.
   Web of Science ®Google Scholar
• Melo CM, Cardoso JF, Perassoli FB, de Oliveira Neto AS, Pinto LM, de Freitas Marques MB, da Nova Mussel W, Magalhães JT, de Lima Moura SA, de Freitas Araújo MG, et al. 2020. Amphotericin B-loaded Eudragit RL100 nanoparticles coated with hyaluronic acid for the treatment of vulvovaginal candidiasis. Carbohydr Polym. 230:115608.
   PubMed Web of Science ®Google Scholar
• Melo MA Jr, Santos LSS, Gonçalves MDC, Nogueira AF. 2012. Preparação de nanopartículas de prata e ouro: um método simples para a introdução da nanociência em laboratório de ensino. Quim Nova. 35:1872–1878.
   Web of Science ®Google Scholar
• Mendes AI, Silva AC, Catita JAM, Cerqueira F, Gabriel C, Lopes CM. 2013. Miconazole-loaded nanostructured lipid carriers (NLC) for local delivery to the oral mucosa: improving antifungal activity. Colloids Surfaces B Biointerfaces. 111:755–763.
   PubMed Web of Science ®Google Scholar
• Mendiratta S, Hussein M, Nasser HA, Ali AAA. 2019. Multidisciplinary role of mesoporous silica nanoparticles in brain regeneration and cancers: from crossing the blood–brain barrier to treatment. Part Part Syst Char. 36:1900195.
   Web of Science ®Google Scholar
• Mezzenga R, Seddon JM, Drummond CJ, Boyd BJ, Schröder-Turk GE, Sagalowicz L. 2019. Nature-inspired design and application of lipidic lyotropic liquid crystals. Adv Mater. 31:1900818.
   Web of Science ®Google Scholar
• Millsop JW, Fazel N. 2016. Oral candidiasis. Clin Dermatol. 34:487–494.
   PubMed Web of Science ®Google Scholar
• Mishra V, Bansal KK, Verma A, Yadav N, Thakur S. 2018. Solid lipid nanoparticles: emerging colloidal nano drug delivery systems. 10:191.
   Google Scholar
• Moazeni M, Kelidari HR, Saeedi M, Morteza-Semnani K, Nabili M, Gohar AA, Akbari J, Lotfali E, Nokhodchi A. 2016. Time to overcome fluconazole resistant Candida isolates: solid lipid nanoparticles as a novel antifungal drug delivery system. Colloids Surfaces B Biointerfaces. 142:400–407.
   PubMed Web of Science ®Google Scholar
• Montazeri M, Razzaghi-Abyaneh M, Nasrollahi SA, Maibach H, Nafisi S. 2020. Enhanced topical econazole antifungal efficacy by amine-functionalized silica nanoparticles. Bull Mater Sci. 43:13.
   Web of Science ®Google Scholar
• Moraes Moreira Carraro TC, Altmeyer C, Maissar Khalil N, Mara Mainardes R. 2017. Assessment of in vitro antifungal efficacy and in vivo toxicity of Amphotericin B-loaded PLGA and PLGA-PEG blend nanoparticles. J Mycol Med. 27:519–529.
   PubMed Web of Science ®Google Scholar
• More MP, Ganguly PR, Pandey AP, Dandekar PP, Jain RD, Patil PO, Deshmukh PK. 2017. Development of surface engineered mesoporous alumina nanoparticles: drug release aspects and cytotoxicity assessment. IET Nanobiotechnology. 11:661–668.
   Web of Science ®Google Scholar
• Mtibaa L, Fakhfakh N, Kallel A, Belhadj S, Belhaj Salah N, Bada N, Kallel K. 2017. Vulvovaginal candidiasis: etiology, symptomatology and risk factors. J Mycol Med. 27:153–158.
   PubMed Web of Science ®Google Scholar
• Nagao M, Saito T, Doi S, Hotta G, Yamamoto M, Matsumura Y, Matsushima A, Ito Y, Takakura S, Ichiyama S. 2012. Clinical characteristics and risk factors of ocular candidiasis. Diagn Microbiol Infect Dis. 73:149–152.
   PubMed Web of Science ®Google Scholar
• Nakajima M, Umezaki Y, Takeda S, Yamaguchi M, Suzuki N, Yoneda M, Hirofuji T, Sekitani H, Yamashita Y, Morita H. 2020. Association between oral candidiasis and bacterial pneumonia: a retrospective study. Oral Dis. 26:234–237.
   PubMed Web of Science ®Google Scholar
• Nett JE. 2018. Special issue: Candida and candidiasis. J Fungi. 4:4–6.
   Web of Science ®Google Scholar
• Ochekpe NA, Olorunfemi PO, Ngwuluka NC. 2009. Nanotechnology and drug delivery part 2: nanostructures for drug delivery. Trop J Pharm Res. 8:275–287.
   Web of Science ®Google Scholar
• Oliva MDLM, Gallucci MN, Carezzano ME, Demo MS. 2013. Natural products as alternative treatments for Candida species resistant to conventional chemotherapeutics. In: Rai MK, Kon KV, editors. Fighting multidrug resistance with herbal extracts, essential oils and their components. New York (NY): Elsevier; p. 31–43.
   Google Scholar
• Otte A, Soh BK, Yoon G, Park K. 2018. Liquid crystalline drug delivery vehicles for oral and IV/subcutaneous administration of poorly soluble (and soluble) drugs. Int J Pharm. 539:175–183.
   PubMedGoogle Scholar
• Padula C, Telò I, Di Ianni A, Pescina S, Nicoli S, Santi P. 2018. Microemulsion containing triamcinolone acetonide for buccal administration. Eur J Pharm Sci. 115:233–239.
   PubMed Web of Science ®Google Scholar
• Panahi Y, Farshbaf M, Mohammadhosseini M, Mirahadi M, Khalilov R, Saghfi S, Akbarzadeh A. 2017. Recent advances on liposomal nanoparticles: synthesis, characterization and biomedical applications. Artif Cells Nanomed Biotechnol. 45:788–799.
   PubMed Web of Science ®Google Scholar
• Pappas PG, Lionakis MS, Arendrup MC, Ostrosky-Zeichner L, Kullberg BJ. 2018. Invasive candidiasis. Nat Publ Gr. 4:1–20.
   Google Scholar
• Paramanantham P, Antony AP, Sruthil Lal SB, Sharan A, Syed A, Ahmed M, et al. 2018. Antimicrobial photodynamic inactivation of fungal biofilm using amino functionalized mesoporus silica-rose bengal nanoconjugate against Candida albicans. Sci African. 1:e00007.
   Google Scholar
• Pardeshi C, Rajput P, Belgamwar V, Tekade A, Patil G, Chaudhary K, Sonje A. 2012. Solid lipid based nanocarriers: an overview/nanonosači na bazi čvrstih lipida: pregled. Acta Pharm. 62:433–472.
   PubMed Web of Science ®Google Scholar
• Pardeike J, Weber S, Haber T, Wagner J, Zarfl HP, Plank H, Zimmer A. 2011. Development of an itraconazole-loaded nanostructured lipid carrier (NLC) formulation for pulmonary application. Int J Pharm. 419(1-2):329–338.
   Google Scholar
• Park J, Wrzesinski SH, Stern E, Look M, Criscione J, Ragheb R, Jay SM, Demento SL, Agawu A, Licona Limon P, et al. 2012. Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy. Nat Mater. 11:895–905.
   PubMed Web of Science ®Google Scholar
• Patel PA, Patravale VB. 2011. AmbiOnp: Solid lipid nanoparticles of amphotericin B for oral administration. J Biomed Nanotechnol. 7:632–639.
   PubMed Web of Science ®Google Scholar
• Peer D, Karp JM, Hong S, Farokhzad OC, Margalit R, Langer R. 2007. Nanocarriers as an emerging platform for cancer therapy. Nature Nanotech. 2:751–760.
   PubMed Web of Science ®Google Scholar
• Pillai AM, Sivasankarapillai VS, Rahdar A, Joseph J, Sadeghfar F, Anuf A R, Rajesh K, Kyzas GZ. 2020. Green synthesis and characterization of zinc oxide nanoparticles with antibacterial and antifungal activity. J Mol Struct. 1211:128107.
   Web of Science ®Google Scholar
• Porto RCT, Uchôa PZ, Peschel LT, Justi B, Koslowski LAD, Nogueira AL. 2017. Nanopartículas de óxido de zinco sintetizadas pelo método poliol: caracterização e avaliação da atividade antibacteriana. Matéria (Rio Janeiro). 22:e11912.
   Google Scholar
• Prabhu S, Poulose EK. 2012. Silver nanoparticles: mechanism of antimicrobial action, synthesis, medical applications, and toxicity effects. Int Nano Lett. 2:32.
   Google Scholar
• Prajapati V, Jain A, Jain R, Sahu S, Kohli DV. 2014. Treatment of cutaneous candidiasis through fluconazole encapsulated cubosomes. Drug Deliv Transl Res. 4:400–408.
   PubMed Web of Science ®Google Scholar
• Prestes PS, Chorilli M, Chiavacci LA, Scarpa MV, Leonardi GR. 2010. Physicochemical characterization and rheological behavior evaluation of the liquid crystalline mesophases developed with different silicones. J Dispers Sci Technol. 31:117–123.
   Web of Science ®Google Scholar
• Przespolewski A, Szeles A, Wang ES. 2018. Advances in immunotherapy for acute myeloid leukemia. Futur Oncol. 14:963–978.
   PubMed Web of Science ®Google Scholar
• Qais FA, Khan MSA, Ahmad I, Althubiani AS. 2019. Potential of nanoparticles in combating candida infections. LDDD. 16:478–491.
   Google Scholar
• Quatrin PM, Verdi CM, de Souza ME, de Godoi SN, Klein B, Gundel A, et al. 2017. Antimicrobial and antibiofilm activities of nanoemulsions containing Eucalyptus globulus oil against Pseudomonas aeruginosa and Candida spp. Microb Pathog. 112:230–242.
   PubMed Web of Science ®Google Scholar
• Quintanar-Guerrero D, Allémann E, Doelker E, Fessi H. 1998. Preparation and characterization of nanocapsules from preformed polymers by a new process based on emulsification-difussion technique. Pharm Res. 15:1056–1062.
   PubMed Web of Science ®Google Scholar
• Rahimi H, Roudbarmohammadi S, Delavari H, Roudbary M. 2019. Antifungal effects of indolicidin-conjugated gold nanoparticles against fluconazole-resistant strains of Candida albicans isolated from patients with burn infection. Int J Nanomedicine. 14:5323–5338.
   PubMed Web of Science ®Google Scholar
• Ramage G, Rajendran R, Sherry L, Williams C. 2012. Fungal biofilm resistance. Int J Microbiol. 2012:1–14.
   Google Scholar
• Ramasamy T, Khandasami US, Ruttala H, Shanmugam S. 2012. Development of solid lipid nanoparticles enriched hydrogels for topical delivery of anti-fungal agent. Macromol Res. 20:682–692.
   Web of Science ®Google Scholar
• Ravani L, Esposito E, Bories C, Moal VLL, Loiseau PM, Djabourov M, Cortesi R, Bouchemal K. 2013. Clotrimazole-loaded nanostructured lipid carrier hydrogels: thermal analysis and in vitro studies. Int J Pharm. 454:695–702.
   PubMed Web of Science ®Google Scholar
• Rizzello L, Cingolani R, Pompa PP. 2013. Nanotechnology tools for antibacterial materials R eview. Nanomedicine. 8:807–821.
   PubMed Web of Science ®Google Scholar
• Rodero CF, Fioramonti Calixto GM, Cristina Dos Santos K, Sato MR, Aparecido Dos Santos Ramos M, Miró MS, Rodríguez E, Vigezzi C, Bauab TM, Sotomayor CE, et al. 2018. Curcumin-loaded liquid crystalline systems for controlled drug release and improved treatment of vulvovaginal candidiasis. Mol Pharm. 15:4491–4504.
   PubMedGoogle Scholar
• Roque L, Castro P, Molpeceres J, Viana AS, Roberto A, Reis C, Rijo P, Tho I, Sarmento B, Reis C. 2018. Bioadhesive polymeric nanoparticles as strategy to improve the treatment of yeast infections in oral cavity: in-vitro and ex-vivo studies. Eur Polym J. 104:19–31.
   Web of Science ®Google Scholar
• Rudokas M, Najlah M, Alhnan MA, Elhissi A. 2016. Liposome delivery systems for inhalation: a critical review highlighting formulation issues and anticancer applications. Med Princ Pract. 25:60–72.
   PubMed Web of Science ®Google Scholar
• Sábio RM, Meneguin AB, Ribeiro TC, Silva RR, Chorilli M. 2019. New insights towards mesoporous silica nanoparticles as a technological platform for chemotherapeutic drugs delivery. Int J Pharm. 564:379–409.
   PubMedGoogle Scholar
• Sakima V, Barbugli P, Cerri P, Chorilli M, Carmello J, Pavarina A, Mima E. 2018. Antimicrobial photodynamic therapy mediated by curcumin-loaded polymeric nanoparticles in a murine model of oral candidiasis. Molecules. 23:2075.
   Web of Science ®Google Scholar
• Salmazi R, Calixto G, Bernegossi J, Aparecido Dos M, Ramos S, Bauab TM. 2015. A curcumin-loaded liquid crystal precursor mucoadhesive system for the treatment of vaginal candidiasis. Int J Nanomedicine. 10:4815–4824.
   PubMed Web of Science ®Google Scholar
• Sangamithra V, Verma R, Sengottuvelu S, Sumathi R. 2013. Candida infections of the genitourinary tract. Res J Pharm Technol. 6:1111–1115.
   Google Scholar
• Sanglard D, Ischer F, Parkinson T, Falconer D, Bille J. 2003. Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents. Antimicrob Agents Chemother. 47:2404–2412.
   PubMed Web of Science ®Google Scholar
• Sanglard D, Odds FC. 2002. Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences. Lancet Infect Dis. 2:73–85.
   PubMed Web of Science ®Google Scholar
• Santos SS, Lorenzoni A, Ferreira LM, Mattiazzi J, Adams AIH, Denardi LB, Alves SH, Schaffazick SR, Cruz L. 2013. Clotrimazole-loaded Eudragit® RS100 nanocapsules: preparation, characterization and in vitro evaluation of antifungal activity against Candida species. Mater Sci Eng C. 33:1389–1394.
   PubMed Web of Science ®Google Scholar
• Santos SS, Lorenzoni A, Pegoraro NS, Denardi LB, Alves SH, Schaffazick SR, Cruz L. 2014. Formulation and in vitro evaluation of coconut oil-core cationic nanocapsules intended for vaginal delivery of clotrimazole. Colloids Surfaces B Biointerfaces. 116:270–276.
   PubMed Web of Science ®Google Scholar
• Scorzoni L, Sangalli-Leite F, de Lacorte Singulani J, de Paula E Silva ACA, Costa-Orlandi CB, Fusco-Almeida AM, Mendes-Giannini MJS. 2016. Searching new antifungals: the use of in vitro and in vivo methods for evaluation of natural compounds. J Microbiol Methods. 123:68–78.
   PubMed Web of Science ®Google Scholar
• Selvaraj M, Pandurangan P, Ramasami N, Rajendran SB, Sangilimuthu SN, Perumal P. 2014. Highly potential antifungal activity of quantum-sized silver nanoparticles against Candida albicans. Appl Biochem Biotechnol. 173:55–66.
   PubMed Web of Science ®Google Scholar
• Shah CP, McKey J, Spirn MJ, Maguire J. 2008. Ocular candidiasis: a review. Br J Ophthalmol. 92:466–468.
   PubMed Web of Science ®Google Scholar
• Shah RM, Malherbe F, Eldridge D, Palombo EA, Harding IH. 2014. Physicochemical characterization of solid lipid nanoparticles (SLNs) prepared by a novel microemulsion technique. J Colloid Interface Sci. 428:286–294.
   PubMed Web of Science ®Google Scholar
• Shaikh S, Nazam N, Rizvi SMD, Ahmad K, Baig MH, Lee EJ, Choi I. 2019. Mechanistic insights into the antimicrobial actions of metallic nanoparticles and their implications for multidrug resistance. IJMS. 20:2468.
   Google Scholar
• Shenoy A, Gottlieb A. 2019. Probiotics for oral and vulvovaginal candidiasis: a review. Dermatol Ther. 32:1–13.
   Web of Science ®Google Scholar
• Silva Pb d, Machado RTA, Pironi AM, Alves RC, de Araújo PR, Dragalzew AC, et al. 2019. Recent advances in the use of metallic nanoparticles with antitumoral action-review. Curr Med Chem. 26:2108–2146.
   PubMed Web of Science ®Google Scholar
• Singh S. 2019. Zinc oxide nanoparticles impacts: Cytotoxicity, genotoxicity, developmental toxicity, and neurotoxicity. Toxicol Mech Methods. 29:300–311.
   PubMed Web of Science ®Google Scholar
• Singh Y, Meher JG, Raval K, Khan FA, Chaurasia M, Jain NK, Chourasia MK. 2017. Nanoemulsion: concepts, development and applications in drug delivery. J Control Release. 252:28–49.
   PubMed Web of Science ®Google Scholar
• Singhvi G, Banerjee S, Khosa A. 2018. Lyotropic liquid crystal nanoparticles: a novel improved lipidic drug delivery system. In: Grumezescu AM, editor. Organic Materials as Smart Nanocarriers for Drug Delivery. Amsterdam (Netherlands): p. 471–517.
   Google Scholar
• Sintov AC, Shapiro L. 2004. New microemulsion vehicle facilitates percutaneous penetration in vitro and cutaneous drug bioavailability in vivo. J Control Release. 95:173–183.
   PubMed Web of Science ®Google Scholar
• Sirelkhatim A, Mahmud S, Seeni A, Kaus NHM, Ann LC, Bakhori SKM, Hasan H, Mohamad D. 2015. Review on zinc oxide nanoparticles: antibacterial activity and toxicity mechanism. Nano-Micro Lett. 7:219–242.
   PubMed Web of Science ®Google Scholar
• Soares MRPS, Corrêa RO, Stroppa PHF, Marques FC, Andrade GFS, Corrêa CC, Brandão MAF, Raposo NRB. 2018. Biosynthesis of silver nanoparticles using Caesalpinia ferrea (Tul.) Martius extract: physicochemical characterization, antifungal activity and cytotoxicity. PeerJ. 6:e4361.
   PubMed Web of Science ®Google Scholar
• Soliman AM, Abdel-Latif W, Shehata IH, Fouda A, Abdo AM, Ahmed YM. 2020. Green approach to overcome the resistance pattern of Candida spp. Using biosynthesized  silver nanoparticles fabricated by Penicillium chrysogenum F9. Biol Trace Elem Res. 523(1):15–32.
   Google Scholar
• Soliman GM. 2017. Nanoparticles as safe and effective delivery systems of antifungal agents: achievements and challenges. Int J Pharm. 523:15–32.
   PubMed Web of Science ®Google Scholar
• Soliman S, Alnajdy D, El-Keblawy A, Mosa K, Khoder G, Noreddin A. 2017. Plants’ natural products as alternative promising anti-Candida drugs. Pharmacogn Rev. 11:104–122.
   PubMedGoogle Scholar
• Song SH, Lee KM, Kang JB, Lee SG, Kang MJ, Choi YW. 2014. Improved skin delivery of voriconazole with a nanostructured lipid carrier-based hydrogel formulation. Chem Pharm Bull. 62:793–798.
   PubMed Web of Science ®Google Scholar
• Sosa L, Clares B, Alvarado HL, Bozal N, Domenech O, Calpena AC. 2017. Amphotericin B releasing topical nanoemulsion for the treatment of candidiasis and aspergillosis. Nanomedicine Nanotechnol Biol Med. 13:2303–2312.
   PubMed Web of Science ®Google Scholar
• Souza C, Watanabe E, Borgheti-Cardoso LN, De Fantini MCA, Lara MG. 2014. Mucoadhesive system formed by liquid crystals for buccal administration of poly(hexamethylene biguanide) hydrochloride. J Pharm Sci. 103:3914–3923.
   PubMed Web of Science ®Google Scholar
• Souza ME, Lopes LQS, Bonez PC, Gündel A, Martinez DST, Sagrillo MR, Giongo JL, Vaucher RA, Raffin RP, Boligon AA, et al. 2017. Melaleuca alternifolia nanoparticles against Candida species biofilms. Microb Pathog. 104:125–132.
   PubMed Web of Science ®Google Scholar
• Spernath A, Aserin A. 2006. Microemulsions as carriers for drugs and nutraceuticals. Adv Colloid Interface Sci. 128–130:47–64.
   PubMed Web of Science ®Google Scholar
• Srivastava N, Patel DK, Rai VK, Pal A, Yadav NP. 2018. Development of emulgel formulation for vaginal candidiasis: Pharmaceutical characterization, in vitro and in vivo evaluation. J Drug Deliv Sci Technol. 48:490–498.
   Web of Science ®Google Scholar
• Strebhardt K, Ullrich A. 2008. Paul Ehrlich’s magic bullet concept: 100 Years of progress. Nat Rev Cancer. 8:473–480.
   PubMed Web of Science ®Google Scholar
• Sun Q, Li J, Le T. 2018. Zinc oxide nanoparticle as a novel class of antifungal agents: current advances and future perspectives. J Agric Food Chem. 66:11209–11220.
   PubMed Web of Science ®Google Scholar
• Sur S, Rathore A, Dave V, Reddy KR, Chouhan RS, Sadhu V. 2019. Recent developments in functionalized polymer nanoparticles for efficient drug delivery system. Nano Structures Nano Objects. 20:100397.
   Google Scholar
• Sutar YB, Telvekar VN. 2018. Chitosan based copolymer-drug conjugate and its protein targeted polyelectrolyte complex nanoparticles to enhance the efficiency and specificity of low potency anticancer agent. Mater Sci Eng C. 92:393–406.
   PubMed Web of Science ®Google Scholar
• Svetlichny G, Külkamp-Guerreiro IC, Cunha SL, Silva FEK, Bueno K, Pohlmann AR, Fuentefria AM, Guterres SS. 2015. Solid lipid nanoparticles containing copaiba oil and allantoin: Development and role of nanoencapsulation on the antifungal activity. Pharmazie. 70:155–164.
   PubMed Web of Science ®Google Scholar
• Tabosa MAM, de Andrade ARB, Lira AAM, Sarmento VHV, de Santana DP, Leal LB. 2018. Microemulsion formulations for the transdermal delivery of lapachol. AAPS PharmSciTech. 19:1837–1846.
   PubMed Web of Science ®Google Scholar
• Takagi Y, Fukano H, Shimozato K, Tanaka R, Horii T, Kawamoto F, Kanbe T. 2013. Genotypes of Candida albicans isolated from healthy individuals and their distribution in patients with oral candidiasis. J Infect Chemother. 19:1072–1079.
   PubMed Web of Science ®Google Scholar
• Tan A, Hong L, Du JD, Boyd BJ. 2019. Self-assembled nanostructured lipid systems: is there a link between structure and cytotoxicity? Adv Sci. 6:1801223.
   Web of Science ®Google Scholar
• Taudorf EH, Jemec GBE, Hay RJ, Saunte DML. 2019. Cutaneous candidiasis – an evidence-based review of topical and systemic treatments to inform clinical practice. J Eur Acad Dermatol Venereol. 33:1863–1873.
   PubMed Web of Science ®Google Scholar
• Tavakoli N, Taymouri S, Saeidi A, Akbari V. 2019. Thermosensitive hydrogel containing sertaconazole loaded nanostructured lipid carriers for potential treatment of fungal keratitis. Pharm Dev Technol. 24:891–901.
   PubMed Web of Science ®Google Scholar
• Tavano L, Muzzalupo R, Picci N, De Cindio B. 2014. Co-encapsulation of lipophilic antioxidants into niosomal carriers: Percutaneous permeation studies for cosmeceutical applications. Colloids Surf B Biointerfaces. 114:144–149.
   PubMed Web of Science ®Google Scholar
• Teles Souza JM, Rodrigues de Araújo A, Aguiar de Carvalho AM, Amorim A. d G N, Daboit TC, Roberto de Souza de Almeida Leite J, Alves da Silva D, Eaton P. 2020. Sustainably produced cashew gum-capped zinc oxide nanoparticles show antifungal activity against Candida parapsilosis. J Clean Prod. 247:119085.
   Web of Science ®Google Scholar
• Tian B, Yan Q, Wang J, Ding C, Sai S. 2017. Enhanced antifungal activity of voriconazole-loaded nanostructured lipid carriers against Candida albicans with a dimorphic switching model. Int J Nanomedicine. 12:7131–7141.
   PubMed Web of Science ®Google Scholar
• Tonglairoum P, Ngawhirunpat T, Rojanarata T, Kaomongkolgit R, Opanasopit P. 2015. Fabrication of a novel scaffold of clotrimazole-microemulsion-containing nanofibers using an electrospinning process for oral candidiasis applications. Colloids Surfaces B Biointerfaces. 126:18–25.
   PubMed Web of Science ®Google Scholar
• Torres-Rêgo M, Gláucia-Silva F, Rocha Soares KS, de Souza LBFC, Damasceno IZ, dos Santos-Silva E, Lacerda AF, Chaves GM, da Silva-Júnior AA, de Freitas Fernandes-Pedrosa M. 2019. Biodegradable cross-linked chitosan nanoparticles improve anti-Candida and anti-biofilm activity of TistH, a peptide identified in the venom gland of the Tityus stigmurus scorpion. Mater Sci Eng C. 103:109830.
   PubMed Web of Science ®Google Scholar
• Uppuluri P, Khan A, Edwards JE. 2017. Chapter 2 – Current trends in candidiasis. In: Prasad R, editor. Candida albicans: cellular and Molecular Biology. 2nd ed. Cham: Springer; p. 5–23.
   Google Scholar
• Urandur S, Marwaha D, Gautam S, Banala VT, Sharma M, Mishra PR. 2018. Nonlamellar liquid crystals: a new paradigm for the delivery of small molecules and bio-macromolecules. Ther Deliv. 9:667–689.
   PubMed Web of Science ®Google Scholar
• Vaghasiya H, Kumar A, Sawant K. 2013. Development of solid lipid nanoparticles based controlled release system for topical delivery of terbinafine hydrochloride. Eur J Pharm Sci. 49:311–322.
   PubMed Web of Science ®Google Scholar
• Veloso DFMC, Benedetti NIGM, Ávila RI, Bastos TSA, Silva TC, Silva MRR, Batista AC, Valadares MC, Lima EM. 2018. Intravenous delivery of a liposomal formulation of voriconazole improves drug pharmacokinetics, tissue distribution, and enhances antifungal activity. Drug Deliv. 25:1585–1594.
   PubMed Web of Science ®Google Scholar
• Vila T, Sultan AS, Montelongo-Jauregui D, Jabra-Rizk MA. 2020. Oral candidiasis: a disease of opportunity. J Fungi. 6:1–28.
   Web of Science ®Google Scholar
• Volpedo G, Costa L, Ryan N, Halsey G, Satoskar A, Oghumu S. 2019. Nanoparticulate drug delivery systems for the treatment of neglected tropical protozoan diseases. J Venom Anim Toxins Incl Trop Dis. 25:e144118.
   PubMed Web of Science ®Google Scholar
• Wang S, Yu S, Lin Y, Zou P, Chai G, Yu HH, Wickremasinghe H, Shetty N, Ling J, Li J, et al. 2018. Co-delivery of ciprofloxacin and colistin in liposomal formulations with enhanced in vitro antimicrobial activities against multidrug resistant Pseudomonas aeruginosa. Pharm Res. 35:1–13.
   Web of Science ®Google Scholar
• Weir E, Lawlor A, Whelan A, Regan F. 2008. The use of nanoparticles in anti-microbial materials and their characterization. Analyst. 133:835–845.
   PubMed Web of Science ®Google Scholar
• Whaley SG, Berkow EL, Rybak JM, Nishimoto AT, Barker KS, Rogers PD. 2017. Azole antifungal resistance  in Candida albicans and emerging non-albicans Candida Species. Front Microbiol. 7. DOI:10.3389/fmicb.2016.02173.
   PubMed Web of Science ®Google Scholar
• Wong HL, Bendayan R, Rauth AM, Li Y, Wu XY. 2007. Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles. Adv Drug Deliv Rev. 59:491–504.
   PubMed Web of Science ®Google Scholar
• Xue B, He D, Gao S, Wang D, Yokoyama K, Wang L. 2016. Biosynthesis of silver nanoparticles by the fungus Arthroderma fulvum and its antifungal activity against genera of Candida, Aspergillus and Fusarium. Int J Nanomedicine. 11:1899–1906.
   PubMed Web of Science ®Google Scholar
• Yasir M, Singh J, Tripathi MK, Singh P, Shrivastava R. 2017. Green synthesis of silver nanoparticles using leaf extract of common arrowhead houseplant and its anticandidal activity. Pharmacogn Mag. 13:S840.
   Google Scholar
• Zida A, Bamba S, Yacouba A, Ouedraogo-Traore R, Guiguemdé RT. 2017. Anti-Candida albicans natural products, sources of new antifungal drugs: a review. J Mycol Med. 27:1–19.
   PubMed Web of Science ®Google Scholar
• Zylberberg C, Matosevic S. 2016. Pharmaceutical liposomal drug delivery: a review of new delivery systems and a look at the regulatory landscape. Drug Deliv. 23:3319–3329.
   PubMed Web of Science ®Google Scholar