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Review Articles

Ambient air pollution and respiratory bacterial infections, a troubling association: epidemiology, underlying mechanisms, and future challenges

ORCID Icon & ORCID Icon
Pages 600-630 | Received 04 Aug 2020, Accepted 26 Aug 2020, Published online: 16 Oct 2020

References

  • Adar SD, Huffnagle GB, Curtis JL. 2016. The respiratory microbiome: an underappreciated player in the human response to inhaled pollutants? Ann Epidemiol. 26(5):355–359.
  • Ahmad S, Nichols DP, Strand M, Rancourt RC, Randell SH, White CW, Ahmad A. 2011. SERCA2 regulates non-CF and CF airway epithelial cell response to ozone. PLoS One. 6(11):e27451.
  • Aller JY, Kuznetsova MR, Jahns CJ, Kemp PF. 2005. The sea surface microlayer as a source of viral and bacterial enrichment in marine aerosols. J Aerosol Sci. 36(5-6):801–812.
  • An S, Sin HH, DuBow MS. 2015. Modification of atmospheric sand-associated bacterial communities during Asian sandstorms in China and South Korea. Heredity (Edinb)). 114(5):460–467.
  • Archer SDJ, Pointing SB. 2020. Anthropogenic impact on the atmospheric microbiome. Nat Microbiol. 5(2):229–231. [
  • Bai KJ, Chuang KJ, Chen JK, Tsai CY, Yang YL, Chang CC, Chen TT, Lee CN, Feng PH, Chen KY, et al. 2019. Alterations by air pollution in inflammation and metals in pleural effusion of pneumonia patients. IJERPH. 16(5):705.
  • Bajantri B, Venkatram S, Diaz-Fuentes G. 2018. Mycoplasma pneumoniae: a potentially severe infection. J Clin Med Res. 10(7):535–544.
  • Bateson TF, Schwartz J. 2008. Children's response to air pollutants. J Toxicol Environ Health Part A. 71(3):238–243.
  • Bauer RN, Diaz-Sanchez D, Jaspers I. 2012. Effects of air pollutants on innate immunity: the role of toll-like receptors and nucleotide-binding oligomerization domain-like receptors. J Allergy Clin Immunol. 129(1):14–24.
  • Becker S, Dailey L, Soukup JM, Silbajoris R, Devlin RB. 2005. TLR-2 is involved in airway epithelial cell response to air pollution particles. Toxicol Appl Pharmacol. 203(1):45–52.
  • Beham AW, Puellmann K, Laird R, Fuchs T, Streich R, Breysach C, Raddatz D, Oniga S, Peccerella T, Findeisen P, et al. 2011. A TNF-regulated recombinatorial macrophage immune receptor implicated in granuloma formation in tuberculosis. PLoS Pathog. 7(11):e1002375
  • Bell ML, Dominici F, Samet JM. 2005. A meta-analysis of time-series studies of ozone and mortality with comparison to the national morbidity, mortality, and air pollution study. Epidemiology. 16(4):436–445.
  • Bengalli R, Molteni E, Longhin E, Refsnes M, Camatini M, Gualtieri M. 2013. Release of IL-1 β triggered by Milan summer PM10: molecular pathways involved in the cytokine release. Biomed Res Int. 2013:158093
  • Bertolini V, Gandolfi I, Ambrosini R, Bestetti G, Innocente E, Rampazzo G, Franzetti A. 2013. Temporal variability and effect of environmental variables on airborne bacterial communities in an urban area of Northern Italy. Appl Microbiol Biotechnol. 97(14):6561–6570.
  • Bono R, Romanazzi V, Bellisario V, Tassinari R, Trucco G, Urbino A, Cassardo C, Siniscalco C, Marchetti P, Marcon A. 2016. Air pollution, aeroallergens and admissions to pediatric emergency room for respiratory reasons in Turin, northwestern Italy. BMC Public Health. 16(1):722.
  • Bowers RM, McCubbin IB, Hallar AG, Fierer N. 2012. Seasonal variability in airborne bacterial communities at a high-elevation site. Atmos Environ. 50:41–49.
  • Bowers RM, McLetchie S, Knight R, Fierer N. 2011. Spatial variability in airborne bacterial communities across land-use types and their relationship to the bacterial communities of potential source environments. Isme J. 5(4):601–612.
  • Brook RD, Rajagopalan S, Pope CA, 3rd, Brook JR, Bhatnagar A, Diez-Roux AV, Holguin F, Hong Y, Luepker RV, Mittleman MA, et al. American Heart Association Council on Epidemiology and Prevention, Council on the Kidney in Cardiovascular Disease, and Council on Nutrition, Physical Activity and Metabolism. 2010. Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association. Circulation. 121(21):2331–2378.,.
  • Brugha R, Edmondson C, Davies JC. 2018. Outdoor Air Pollution and Cystic Fibrosis. Paediatr Respir Rev. 28:80–86.
  • Brugha R, Grigg J. 2014. Urban air pollution and respiratory infections. Paediatr Respir Rev. 15(2):194–199.
  • Burchiel SW, Luster MI. 2001. Signaling by environmental polycyclic aromatic hydrocarbons in human lymphocytes. Clin Immunol. 98(1):2–10.
  • Burrows S, Butler T, Jockel P, Tost H, Kerkweg A, Poschl U, Lawrence M. 2009. Bacteria in the global atmosphere. Part 2: modeling of emissions and transport between different ecosystems. Atmos Chem Phys. 9(23):9281e9297.
  • Cantin AM, Hartl D, Konstan MW, Chmiel JF. 2015. Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy. J Cyst Fibros. 14(4):419–430.
  • Caraballo JC, Yshii C, Westphal W, Moninger T, Comellas AP. 2011. Ambient particulate matter affects occludin distribution and increases alveolar transepithelial electrical conductance. Respirology. 16(2):340–349.
  • Chang X, Zhou L, Tang M, Wang B. 2015. Association of fine particles with respiratory disease mortality: a meta-analysis. Arch Environ Occup Health. 70(2):98–101.
  • Chauhan AJ, Johnston SL. 2003. Air pollution and infection in respiratory illness. Br Med Bull. 68:95–112.
  • Chen X, Liu J, Zhou J, Wang J, Chen C, Song Y, Pan J. 2018. Urban particulate matter (PM) suppresses airway antibacterial defence. Respir Res. 19(1):5
  • Cheng Y, Engling G, He KB, Duan FK, Du ZY, Ma YL, Liang LL, Lu ZF, Liu JM, Zheng M, et al. 2014. The characteristics of Beijing aerosol during two distinct episodes: impacts of biomass burning and fireworks. Environ Pollut. 185:149–157.
  • Cho I, Blaser MJ. 2012. The human microbiome: at the interface of health and disease. Nat Rev Genet. 13(4):260–270.
  • Clarke RW, Antonini JM, Hemenway DR, Frank R, Kleeberger SR, Jakab GJ. 2000. Inhaled particle-bound sulfate: effects on pulmonary inflammatory responses and alveolar macrophage function. Inhal Toxicol. 12(3):169–186.
  • Claude JA, Grimm A, Savage HP, Pinkerton KE. 2012. Perinatal exposure to environmental tobacco smoke (ETS) enhances susceptibility to viral and secondary bacterial infections. Int J Environ Res Public Health. 9(11):3954–3964.
  • Cohen AJ, Brauer M, Burnett R, Anderson HR, Frostad J, Estep K, Balakrishnan K, Brunekreef B, Dandona L, Dandona R, et al. 2017. Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015. Lancet. 389(10082):1907–1918.
  • Croft DP, Zhang W, Lin S, Thurston SW, Hopke PK, Masiol M, Squizzato S, van Wijngaarden E, Utell MJ, Rich DQ. 2019. The association between respiratory infection and air pollution in the setting of air quality policy and economic change. Ann Am Thorac Soc. 16(3):321–330.
  • Darrow LA, Klein M, Flanders WD, Mulholland JA, Tolbert PE, Strickland MJ. 2014. Air pollution and acute respiratory infections among children 0-4 years of age: an 18-year time-series study. Am J Epidemiol. 180(10):968–977.
  • Degobbi C, Saldiva PHN, Rogers C. 2011. Endotoxin as modifier of particulate matter toxicity: a review of the literature. Aerobiologia. 27(2):97–105.
  • DeLeon-Rodriguez N, Lathem TL, Rodriguez-R LM, Barazesh JM, Anderson BE, Beyersdorf AJ, Ziemba LD, Bergin M, Nenes A, Konstantinidis KT. 2013. Microbiome of the upper troposphere: species composition and prevalence, effects of tropical storms, and atmospheric implications. Proc Natl Acad Sci USA. 110(7):2575–2580.
  • Després VR, Huffman JA, Burrows SM, Safatov AS, Buryak G, Fröhlich-Nowoisky J, Elbert W, Meinrat OA, Pöschl U, Jaenicke R. 2012. Primary biological aerosol particles in the atmosphere: a review. Tellus B: Chem Phys Meteorol. 64:1–58.
  • Donaldson K, MacNee W, Stone V. 2006. Environmental pollutants. Particulate matter. Ultrafine particles. In: Geoffrey J. Laurent, Steven D. Shapiro, editors. Encyclopedia of respiratory medicine. Cambridge (USA): Academic Press; p. 104–110.
  • Edgar PLH, Stephens R, Doerr RC, Scott WE. 1956. Reactions of nitrogen dioxide and organic compounds in air. Ind Eng Chem. 48(9):1498–1504.
  • European Environment Agency. 2019. Air quality in Europe - report. EEA Report No 10/2019.
  • Farhat SCL, Almeida MB, Silva-Filho LVRF, Farhat J, Rodrigues JC, Braga ALF. 2013. Ozone is associated with an increased risk of respiratory exacerbations in patients with cystic fibrosis. Chest. 144(4):1186–1192.
  • Finlayson-Pitts BJ, Pitts JN. Jr. 2000. Chemistry of the Upper and Lower Atmosphere. San Diego: Academic Press; Published by Elsevier Inc.
  • Fraga J, Botelho A, Sá A, Costa M, Quaresma M. 2011. The lag structure and the general effect of ozone exposure on pediatric respiratory morbidity. Int J Environ Res Public Health. 8(10):4013–4024.
  • Fröhlich-Nowoisky J, Kampf CJ, Weber B, Huffman JA, Pöhlker C, Andreae MO, Lang-Yona N, Burrows SM, Gunthe SS, Elbert W, et al. 2016. Bioaerosols in the Earth system: Climate, health, and ecosystem interactions. Atmos Res. 182:346–376.
  • Gandini M, Scarinzi C, Bande S, Berti G, Carnà P, Ciancarella L, Costa G, Demaria M, Ghigo S, Piersanti A, LIFE MEDHISS collaborative Group, et al. 2018. Long term effect of air pollution on incident hospital admissions: Results from the Italian Longitudinal Study within LIFE MED HISS project. Environ Int. 121(Pt 2):1087–1097.
  • Gaviria-Figueroa A, Preisner EC, Hoque S, Feigley CE, Norman RS. 2019. Emission and dispersal of antibiotic resistance genes through bioaerosols generated during the treatment of municipal sewage. Sci Total Environ. 686:402–412.
  • GBD 2016 Lower Respiratory Infections Collaborators. 2018. Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Infect Dis. 18(11):1191–1210.
  • Ge E, Lai K, Xiao X, Luo M, Fang Z, Zeng Y, Ju H, Zhong N. 2018. Differential effects of size-specific particulate matter on emergency department visits for respiratory and cardiovascular diseases in Guangzhou, China. Environ Pollut. 243(Pt A):336–345.
  • Geiser M, Stoeger T, Casaulta M, Chen S, Semmler-Behnke M, Bolle I, Takenaka S, Kreyling WG, Schulz H. 2014. Biokinetics of nanoparticles and susceptibility to particulate exposure in a murine model of cystic fibrosis. Part Fibre Toxicol. 11:19.
  • Geiser M. 2010. Update on macrophage clearance of inhaled micro- and nanoparticles. J Aerosol Med Pulm Drug Deliv. 23(4):207–217.
  • Ghio AJ, Carraway MS, Madden MC. 2012. Composition of air pollution particles and oxidative stress in cells, tissues, and living systems. J Toxicol Environ Health B Crit Rev. 15(1):1–21.
  • Glencross DA, Ho TR, Camiña N, Hawrylowicz CM, Pfeffer PE. 2020. Air pollution and its effects on the immune system. Free Radic Biol Med. 151:56–68.
  • Goeminne PC, Kiciński M, Vermeulen F, Fierens F, De Boeck K, Nemery B, Nawrot TS, Dupont LJ. 2013. Impact of air pollution on cystic fibrosis pulmonary exacerbations: a case-crossover analysis. Chest. 143(4):946–954.
  • Goss CH, Newsom SA, Schildcrout JS, Sheppard L, Kaufman JD. 2004. Effect of ambient air pollution on pulmonary exacerbations and lung function in cystic fibrosis. Am J Respir Crit Care Med. 169(7):816–821.
  • Grief SN. 2013. Upper respiratory infections. Prim Care. 40(3):757–770.
  • Griffin DW. 2007. Atmospheric movement of microorganisms in clouds of desert dust and implications for human health. Clin Microbiol Rev. 20(3):459–477.
  • Grigg J. 2018. Air pollution and respiratory infection: an emerging and troubling association. Am J Respir Crit Care Med. 198(6):700–701.
  • Gualtieri M, Mantecca P, Corvaja V, Longhin E, Perrone MG, Bolzacchini E, Camatini M. 2009. Winter fine particulate matter from Milan induces morphological and functional alterations in human pulmonary epithelial cells (A549). Toxicol Lett. 188(1):52–62.
  • Guo H, Sahu SK, Kota SH, Zhang H. 2019. Characterization and health risks of criteria air pollutants in Delhi, 2017. Chemosphere. 225:27–34.
  • He M, Ichinose T, Yoshida S, Ito T, He C, Yoshida Y, Arashidani K, Takano H, Sun G, Shibamoto T. 2017. PM2.5-induced lung inflammation in mice: Differences of inflammatory response in macrophages and type II alveolar cells. J Appl Toxicol. 37(10):1203–1218.
  • He M, Ichinose T, Yoshida S, Shiba F, Arashidani K, Takano H, Sun G, Shibamoto T. 2016. Differences in allergic inflammatory responses in murine lungs: Comparison of PM2.5 and coarse PM collected during the hazy events in a Chinese city. Inhal Toxicol. 5:1–13.
  • He S, Tang S, Xiao Y, Cheke RA. 2018. Stochastic Modelling of Air Pollution Impacts on Respiratory Infection Risk. Bull Math Biol. 80(12):3127–3153.
  • Heidelberg JF, Shahamat M, Levin M, Rahman I, Stelma G, Grim C, Colwell RR. 1997. Effect of aerosolization on culturability and viability of Gram-negative bacteria. Appl Environ Microbiol. 63(9):3585–3588.
  • Hien PD, Loc PD, Dao NV. 2011. Air pollution episodes associated with East Asian winter monsoons. Sci Total Environ. 409(23):5063–5068.
  • Hollingsworth JW, Kleeberger SR, Foster WM. 2007. Ozone and pulmonary innate immunity. Proc Am Thorac Soc. 4(3):240–246.
  • Horne BD, Joy EA, Hofmann MG, Gesteland PH, Cannon JB, Lefler JS, Blagev DP, Korgenski EK, Torosyan N, Hansen GI, et al. 2018. Short-term elevation of fine particulate matter air pollution and acute lower respiratory infection. Am J Respir Crit Care Med. 198(6):759–766. III.
  • Huang R-J, Zhang Y, Bozzetti C, Ho K-F, Cao J-J, Han Y, Daellenbach KR, Slowik JG, Platt SM, Canonaco F, et al. 2014. High secondary aerosol contribution to particulate pollution during haze events in China. Nature. 514(7521):218–222.
  • Huang YJ, Charlson ES, Collman RG, Colombini-Hatch S, Martinez FD, Senior RM. 2013. The role of the lung microbiome in health and disease. A National Heart, Lung, and Blood Institute workshop report. Am J Respir Crit Care Med. 187(12):1382–1387.
  • Hůnová I, Malý M, Řezáčová J, Braniš M. 2013. Association between ambient ozone and health outcomes in Prague. Int Arch Occup Environ Health. 86(1):89–97.
  • Hurtado L, Rodríguez G, López J, Castillo JE, Molina L, Zavala M, Quintana PJE. 2014. Characterization of atmospheric bioaerosols at 9 sites in Tijuana, Mexico. Atmos Environ. 96:430–436.
  • Hussey SJK, Purves J, Allcock N, Fernandes VE, Monks PS, Ketley JM, Andrew PW, Morrissey JA. 2017. Air pollution alters Staphylococcus aureus and Streptococcus pneumoniae biofilms, antibiotic tolerance and colonisation. Environ Microbiol. 19(5):1868–1880.
  • Jassal MS, Bakman I, Jones B. 2013. Correlation of ambient pollution levels and heavily-trafficked roadway proximity on the prevalence of smear-positive tuberculosis. Public Health. 127(3):268–274.
  • Jassal MS, Yu AM, Bhatia R, Keens TG, Davidson Ward SL. 2013. Effect of residential proximity to major roadways on cystic fibrosis exacerbations. Int J Environ Health Res. 23(2):119–131.
  • Jedrychowski W, Galas A, Pac A, Flak E, Camman D, Rauh V, Perera F. 2005. Prenatal ambient air exposure to polycyclic aromatic hydrocarbons and the occurrence of respiratory symptoms over the first year of life. Eur J Epidemiol. 20(9):775–782.
  • Jedrychowski WA, Perera FP, Spengler JD, Mroz E, Stigter L, Flak E, Majewska R, Klimaszewska-Rembiasz M, Jacek R. 2013. Intrauterine exposure to fine particulate matter as a risk factor for increased susceptibility to acute broncho-pulmonary infections in early childhood. Int J Hyg Environ Health. 216(4):395–401.
  • Jeon EM, Kim HJ, Jung K, Kim JH, Kim MY, Kim YP, Ka J. 2011. Impact of Asian dust events on airborne bacterial community assessed by molecular analyses. Atmos Environ. 45(25):4313–4321.
  • Ji D, Cui Y, Li L, He J, Wang L, Zhang H, Wang W, Zhou L, Maenhaut W, Wen T, et al. 2018. Characterization and source identification of fine particulate matter in urban Beijing during the 2015 Spring Festival. Sci Total Environ. 628-629:430–440.
  • Ji L, Zhang Q, Fu X, Zheng L, Dong J, Wang J, Guo S. 2019. Feedback of airborne bacterial consortia to haze pollution with different PM2.5 levels in typical mountainous terrain of Jinan, China. Sci Total Environ. 695:133912
  • Kaisho T, Akira S. 2001. Toll-like receptors and their signaling mechanism in innate immunity. Acta Odontol Scand. 59(3):124–130.
  • Kamdar O, Le W, Zhang J, Ghio AJ, Rosen GD, Upadhyay D. 2008. Air pollution induces enhanced mitochondrial oxidative stress in cystic fibrosis airway epithelium. FEBS Lett. 582(25-26):3601–3606.
  • Kampa M, Castanas E. 2008. Human health effects of air pollution. Environ Pollut. 151(2):362–367.
  • Kampfrath T, Maiseyeu A, Ying Z, Shah Z, Deiuliis JA, Xu X, Kherada N, Brook RD, Reddy KM, Padture NP, et al. 2011. Chronic fine particulate matter exposure induces systemic vascular dysfunction via NADPH oxidase and TLR4 pathways. Circ Res. 108(6):716–726.
  • Kellogg CA, Griffin DW, Garrison VH, Peak KK, Royall N, Smith RR, Shinn EA. 2004. Characterization of aerosolised bacteria and fungi from desert events in Mali. West Africa. Aerobiologia. 20(2):99–110.
  • Kennedy CM, Pennington AF, Darrow LA, Klein M, Zhai X, Bates JT, Russell AG, Hansen C, Tolbert PE, Strickland MJ. 2018. Associations of mobile source air pollution during the first year of life with childhood pneumonia, bronchiolitis, and otitis media. Environ Epidemiol. 2(1):e007.
  • Kienast K, MüLler-Quernheim J, Knorst M, Lubjuhn S, Ferlinz R. 1994. In vitro study of human alveolar macrophage and peripheral blood mononuclear cell reactive oxygen-intermediates release induced by sulfur dioxide at different concentrations. Lung. 172(6):335–345.
  • Kim H, Yu S, Choi H. 2020. Effects of particulate air pollution on tuberculosis development in seven major cities of Korea from 2010 to 2016: methodological considerations involving long-term exposure and time lag. Epidemiol Health. 42:e2020012
  • Kim KH, Kabir E, Kabir S. 2015. A review on the human health impact of airborne particulate matter. Environ Int. 74:136–143.
  • Knorst MM, Kienast K, Groß S, Fries B, Müller-Quernheim J, Ferlinz R. 1996. Chemotactic response of human alveolar macrophages and blood monocytes elicited by exposure to sulfur dioxide. Res Exp Med. 196(1):127–135.
  • Knorst MM, Kienast K, Muller-Quernheim J, Ferlinz R. 1996. Effect of sulfur dioxide on cytokine production of human alveolar macrophages in vitro. Arch Environ Health. 51(2):150–156.
  • Kosmider B, Loader JE, Murphy RC, Mason RJ. 2010. Apoptosis induced by ozone and oxysterols in human alveolar epithelial cells. Free Radic Biol Med. 48(11):1513–1524.
  • Kunkel D, Lawrence MG, Tost H, Kerkweg A, Jöckel P, Borrmann S. 2012. Urban emission hot spots as sources for remote aerosol deposition: remote aerosol deposition. Geophys Res Lett. 39:L01808.
  • Lee JY, Park EH, Lee S, Ko G, Honda Y, Hashizume M, Deng F, Yi SM, Kim H. 2017. Airborne bacterial communities in three east Asian cities of China, South Korea, and Japan. Sci Rep. 7(1):5545
  • Lei MT, Monjardino J, Mendes L, Gonçalves D, Ferreira F. 2020. Statistical forecast of pollution episodes in Macao during National Holiday and COVID-19. IJERPH. 17(14):5124.
  • Lelieveld J, Evans JS, Fnais M, Giannadaki D, Pozzer A. 2015. The contribution of outdoor air pollution sources to premature mortality on a global scale. Nature. 525(7569):367–371. e
  • Lewis K. 2009. Persisters, biofilms, and the problem of cultivability. In: Epstein, S.S. (Ed.), Uncultivated Microorganisms. Heidelberg, Berlin, Heidelberg: Springer, p. 203–216.
  • Li D, Zhang R, Cui L, Chu C, Zhang H, Sun H, Luo J, Zhou L, Chen L, Cui J, et al. 2019. Multiple organ injury in male C57BL/6J mice exposed to ambient particulate matter in a real-ambient PM exposure system in Shijiazhuang, China. Environ Pollut. 248:874–887.
  • Li N, He F, Liao B, Zhou Y, Li B, Ran P. 2017. Exposure to ambient particulate matter alters the microbial composition and induces immune changes in rat lung. Respir Res. 18(1):143
  • Li R, Kou X, Geng H, Xie J, Yang Z, Zhang Y, Cai Z, Dong C. 2015. Effect of ambient PM(2.5) on lung mitochondrial damage and fusion/fission gene expression in rats. Chem Res Toxicol. 28(3):408–418.
  • Li YR, Xiao CC, Li J, Tang J, Geng XY, Cui LJ, Zhai JX. 2018. Association between air pollution and upper respiratory tract infection in hospital outpatients aged 0-14 years in Hefei, China: a time series study. Public Health. 156:92–100.
  • Lighthart B. 2000. Mini-review of the concentration variations found in the alfresco atmospheric bacterial populations. Aerobiologia. 16(1):7–16.
  • Liu J, Chen X, Dou M, He H, Ju M, Ji S, Zhou J, Chen C, Zhang D, Miao C, et al. 2019. Particulate matter disrupts airway epithelial barrier via oxidative stress to promote Pseudomonas aeruginosa infection. J Thorac Dis. 11(6):2617–2627.
  • Liu J, Li Y, Li J, Liu Y, Tao N, Song W, Cui L, Li H. 2019. Association between ambient PM2.5 and children's hospital admissions for respiratory diseases in Jinan, China. Environ Sci Pollut Res Int. 26(23):24112–24120.
  • Liu JC, Mickley LJ, Sulprizio MP, Dominici F, Yue X, Ebisu K, Anderson GB, Khan RFA, Bravo MA, Bell ML. 2016. Particulate Air Pollution from Wildfires in the Western US under Climate Change. Clim Change. 138(3):655–666.
  • Liu Y, Cui L, Hou L, Yu C, Tao N, Liu J, Li Y, Zhou C, Yang G, Li H. 2018. Ambient Air Pollution Exposures and Newly Diagnosed Pulmonary Tuberculosis in Jinan. Sci Rep. 8(1):17411.
  • Long T, Peng B, Yang Z, Ishimwe CS, Tang C, Zhao N, Lin H, Zhong K, Zhong S. 2020. Spatial distribution and formation mechanism of water-soluble inorganic ions in PM2.5 during a typical winter haze episode in Guilin, China. Arch Environ Contam Toxicol. 78(3):367–376.
  • Losacco C, Perillo A. 2018. Particulate matter air pollution and respiratory impact on humans and animals. Environ Sci Pollut Res Int. 25(34):33901–33910.
  • MacIntyre EA, Gehring U, Mölter A, Fuertes E, Klümper C, Krämer U, Quass U, Hoffmann B, Gascon M, Brunekreef B, et al. 2014. Air pollution and respiratory infections during early childhood: an analysis of 10 European birth cohorts within the ESCAPE project. Environ Health Perspect. 122(1):107–113.
  • Madhwal S, Prabhu V, Sundriyal S, Shridhar V. 2020. Ambient bioaerosol distribution and associated health risks at a high traffic density junction at Dehradun city, India. Environ Monit Assess. 192(3):196.
  • Mao M, Zhang X, Shao Y, Yin Y. 2019. Spatiotemporal Variations and Factors of Air Quality in Urban Central China during 2013-2015. IJERPH. 17(1):229.
  • Marone A, Kane CT, Mbengue M, Jenkins GS, Niang DN, Drame MS, Gernand JM. 2020. Characterization of Bacteria on Aerosols From Dust Events in Dakar, Senegal, West Africa. Geohealth. 4(6):e2019GH000216.
  • Marriott HM, Jackson LE, Wilkinson TS, Simpson AJ, Mitchell TJ, Buttle DJ, Cross SS, Ince PG, Hellewell PG, Whyte MK, et al. 2008. Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia. Am J Respir Crit Care Med. 177(8):887–895.
  • Masri S, Kang CM, Koutrakis P. 2015. Composition and sources of fine and coarse particles collected during 2002-2010 in Boston, MA. J Air Waste Manag Assoc. 65(3):287–297.
  • Mayol E, Arrieta JM, Jiménez MA, Martínez-Asensio A, Garcias-Bonet N, Dachs J, González-Gaya B, Royer SJ, Benítez-Barrios VM, Fraile-Nuez E, et al. 2017. Long-range transport of airborne microbes over the global tropical and subtropical ocean. Nat Commun. 8(1):201.
  • McEachran AD, Blackwell BR, Hanson JD, Wooten KJ, Mayer GD, Cox SB, Smith PN. 2015. Antibiotics, bacteria, and antibiotic resistance genes: aerial transport from cattle feed yards via particulate matter. Environ Health Perspect. 123(4):337–343.
  • Mikerov AN, Cooper TK, Wang G, Hu S, Umstead TM, Phelps DS, Floros J. 2011. Histopathologic evaluation of lung and extrapulmonary tissues show sex differences in Klebsiella pneumoniae-infected mice under different exposure conditions. Int J Physiol Pathophysiol Pharmacol. 3(3):176–190.
  • Mikerov AN, Gan X, Umstead TM, Miller L, Chinchilli VM, Phelps DS, Floros J. 2008. Sex differences in the impact of ozone on survival and alveolar macrophage function of mice after Klebsiella pneumoniae infection. Respir Res. 9:24.
  • Mikerov AN, Haque R, Gan X, Guo X, Phelps DS, Floros J. 2008. Ablation of SP-A has a negative impact on the susceptibility of mice to Klebsiella pneumoniae infection after ozone exposure: Sex differences. Respir Res. 9(1):77.
  • Miyata R, van Eeden SF. 2011. The innate and adaptive immune response induced by alveolar macrophages exposed to ambient particulate matter. Toxicol Appl Pharmacol. 257(2):209–226.
  • Moller P, Loft S. 2010. Oxidative damage to DNA and lipids as biomarkers of exposure to air pollution. Environ Health Perspect. 118(8):1126–1136.
  • Mudway IS, Kelly FJ. 2000. Ozone and the lung: a sensitive issue. Mol Aspects Med. 21(1-2):1–48.
  • Murdoch DR, Werno AM, Jennings LC. 2019. Microbiological diagnosis of respiratory illness: recent advances. Kendig's disorders of the respiratory tract in children. e3. :396–405.
  • Mushtaq N, Ezzati M, Hall L, Dickson I, Kirwan M, Png KM, Mudway IS, Grigg J. 2011. Adhesion of Streptococcus pneumoniae to human airway epithelial cells exposed to urban particulate matter. J Allergy Clin Immunol. 127(5):1236–1242.
  • Mutlu EA, Comba IY, Cho T, Engen PA, Yazıcı C, Soberanes S, Hamanaka RB, Niğdelioğlu R, Meliton AY, Ghio AJ, et al. 2018. Inhalational exposure to particulate matter air pollution alters the composition of the gut microbiome. Environ Pollut. 240:817–830.
  • Neupane B, Jerrett M, Burnett RT, Marrie T, Arain A, Loeb M. 2010. Long-term exposure to ambient air pollution and risk of hospitalization with community-acquired pneumonia in older adults. Am J Respir Crit Care Med. 181(1):47–53.
  • O’Dowd CD, de Leeuw G. 2007. Marine aerosol production: a review of the current knowledge. Philos Trans R Soc Math Phys Eng Sci. 365:1753–1774.
  • O'Driscoll CA, Gallo ME, Hoffmann EJ, Fechner JH, Schauer JJ, Bradfield CA, Mezrich JD. 2018. Polycyclic aromatic hydrocarbons (PAHs) present in ambient urban dust drive proinflammatory T cell and dendritic cell responses via the aryl hydrocarbon receptor (AHR) in vitro. PLoS One. 13(12):e0209690
  • Olivieri D, Scoditti E. 2005. Impact of environmental factors on lung defenses. Eur Respir Rev. 14(95):51–56.
  • Pang N, Gao J, Che F, Ma T, Liu S, Yang Y, Zhao P, Yuan J, Liu J, Xu Z, et al. 2020. Cause of PM2.5 pollution during the 2016-2017 heating season in Beijing, Tianjin, and Langfang. China. J Environ Sci (China). 95:201–209.
  • Pasteur L. 1861. Mémoire sur les corpuscules organises qui existent dans l’atmosphére, examen de la doctrine des générations spontanées. Ann Sci Nat Zool. 16:5–e98.
  • Peng RD, Dominici F, Pastor-Barriuso R, Zeger SL, Samet JM. 2005. Seasonal analyses of air pollution and mortality in 100 US cities. Am J Epidemiol. 161(6):585–594.
  • Peng Z, Liu C, Xu B, Kan H, Wang W. 2017. Long-term exposure to ambient air pollution and mortality in a Chinese tuberculosis cohort. Sci Total Environ. 580:1483–1488.
  • Peyrani P, Mandell L, Torres A, Tillotson GS. 2019. The burden of community-acquired bacterial pneumonia in the era of antibiotic resistance. Expert Rev Respir Med. 13(2):139–152.
  • Pirozzi CS, Jones BE, VanDerslice JA, Zhang Y, Paine R, III, Dean NC. 2018. Short-term air pollution and incident pneumonia. A case-crossover study. Ann Am Thorac Soc. 15(4):449–459.
  • Pöschl U. 2005. Atmospheric aerosols: composition, transformation, climate and health effects. Angew Chem Int Ed Engl. 44(46):7520–7540.
  • Psoter KJ, De Roos AJ, Mayer JD, Kaufman JD, Wakefield J, Rosenfeld M. 2015. Fine particulate matter exposure and initial Pseudomonas aeruginosa acquisition in cystic fibrosis. Ann Am Thorac Soc. 12(3):385–391.
  • Psoter KJ, De Roos AJ, Wakefield J, Mayer JD, Rosenfeld M. 2017. Air pollution exposure is associated with MRSA acquisition in young U.S. children with cystic fibrosis. BMC Pulm Med. 17(1):106.
  • Qin N, Liang P, Wu C, Wang G, Xu Q, Xiong X, Wang T, Zolfo M, Segata N, Qin H, et al. 2020. Longitudinal survey of microbiome associated with particulate matter in a megacity. Genome Biol. 21(1):55.
  • Qiu H, Tian LW, Pun VC, Ho KKF, Wong TW, Yu ITS. 2014. Coarse particulate matter associated with increased risk of emergency hospital admissions for pneumonia in Hong Kong. Thorax. 69(11):1027–1033.
  • Qu F, Qin XQ, Cui YR, Xiang Y, Tan YR, Liu HJ, Peng LH, Zhou XY, Liu C, Zhu XL. 2009. Ozone stress down-regulates the expression of cystic fibrosis transmembrane conductance regulator in human bronchial epithelial cells. Chem Biol Interact. 179(2-3):219–226.
  • Rahman I. 2005. Oxidative stress in pathogenesis of chronic obstructive pulmonary disease: cellular and molecular mechanisms. Cell Biochem Biophys. 43(1):167–188.
  • Rice MB, Rifas-Shiman SL, Oken E, Gillman MW, Ljungman PL, Litonjua AA, Schwartz J, Coull BA, Zanobetti A, Koutrakis P, et al. 2015. Exposure to traffic and early life respiratory infection: A cohort study. Pediatr Pulmonol. 50(3):252–259.
  • Rivas-Santiago CE, Sarkar S, Cantarella P, 4th, Osornio-Vargas Á, Quintana-Belmares R, Meng Q, Kirn TJ, Ohman Strickland P, Chow JC, Watson JG, et al. 2015. Air pollution particulate matter alters antimycobacterial respiratory epithelium innate immunity. Infect Immun. 83(6):2507–2517.
  • Rychlik KA, Secrest JR, Lau C, Pulczinski J, Zamora ML, Leal J, Langley R, Myatt LG, Raju M, Chang RC, et al. 2019. In utero ultrafine particulate matter exposure causes offspring pulmonary immunosuppression. Proc Natl Acad Sci USA. 116(9):3443–3448.
  • Rylance J, Fullerton DG, Scriven J, Aljurayyan AN, Mzinza D, Barrett S, Wright AK, Wootton DG, Glennie SJ, Baple K, et al. 2015. Household air pollution causes dose-dependent inflammation and altered phagocytosis in human macrophages. Am J Respir Cell Mol Biol. 52(5):584–593.
  • Rylander R. 2006. Endotoxin and occupational airway disease. Curr Opin Allergy Clin Immunol. 6(1):62–66.
  • Schraufnagel DE. 2020. The health effects of ultrafine particles. Exp Mol Med. 52(3):311–317.
  • Segersson D, Eneroth K, Gidhagen L, Johansson C, Omstedt G, Nylén AE, Forsberg B. 2017. Health impact of PM10, PM2.5 and black carbon exposure due to different source sectors in Stockholm, Gothenburg and Umea, Sweden. IJERPH. 14(7):742.
  • Shao J, Zosky GR, Wheeler AJ, Dharmage S, Dalton M, Williamson GJ, O'Sullivan T, Chappell K, Knibbs LD, Johnston FH. 2020. Exposure to air pollution during the first 1000 days of life and subsequent health service and medication usage in children. Environ Pollut. 256:113340.
  • Shiraiwa M, Ueda K, Pozzer A, Lammel G, Kampf CJ, Fushimi A, Enami S, Arangio AM, Fröhlich-Nowoisky J, Fujitani Y, et al. 2017. Aerosol health effects from molecular to global scales. Environ Sci Technol. 51(23):13545–13567.
  • Shoenfelt J, Mitkus RJ, Zeisler R, Spatz RO, Powell J, Fenton MJ, Squibb KA, Medvedev AE. 2009. Involvement of TLR2 and TLR4 in inflammatory immune responses induced by fine and coarse ambient air particulate e matter. J Leukoc Biol. 86(2):303–312.
  • Sigaud S, Goldsmith CA, Zhou H, Yang Z, Fedulov A, Imrich A, Kobzik L. 2007. Air pollution particles diminish bacterial clearance in the primed lungs of mice. Toxicol Appl Pharmacol. 223(1):1–9.
  • Smets W, Moretti S, Denys S, Lebeer S. 2016. Airborne bacteria in the atmosphere: Presence, purpose, and potential. Atmos Environ. 139:214–221.
  • Smit LAM, Boender GJ, de Steenhuijsen Piters WAA, Hagenaars TJ, Huijskens EGW, Rossen JWA, Koopmans M, Nodelijk G, Sanders EAM, Yzermans J, et al. 2017. Increased risk of pneumonia in residents living near poultry farms: does the upper respiratory tract microbiota play a role? Pneumonia (Nathan). 9(1):3.
  • Smith GS, Van Den Eeden SK, Garcia C, Shan J, Baxter R, Herring AH, Richardson DB, Van Rie A, Emch M, Gammon MD. 2016. Air pollution and pulmonary tuberculosis: a nested case-control study among members of a Northern California Health Plan. Environ Health Perspect. 124(6):761–768.
  • Soh SE, Goh A, Teoh OH, Godfrey KM, Gluckman PD, Shek LP, Chong YS. 2018. Pregnancy trimester-specific exposure to ambient air pollution and child respiratory health outcomes in the first 2 years of life: effect modification by maternal pre-pregnancy BMI. IJERPH. 15(5):996.
  • Sterling T, Dimich H, Kobayashi D. 1982. Indoor byproduct levels of tobacco smoke: a critical review of the literature. J Air Pollut Control Assoc. 32(3):250–259.
  • Stern G, Latzin P, Röösli M, Fuchs O, Proietti E, Kuehni C, Frey U. 2013. A prospective study of the impact of air pollution on respiratory symptoms and infections in infants. Am J Respir Crit Care Med. 187(12):1341–1348.
  • Suraju MO, Lalinde-Barnes S, Sanamvenkata S, Esmaeili M, Shishodia S, Rosenzweig JA. 2015. The effects of indoor and outdoor dust exposure on the growth, sensitivity to oxidative-stress, and biofilm production of three opportunistic bacterial pathogens. Sci Total Environ. 538:949–958.
  • Tam WW, Wong TW, Ng L, Wong SY, Kung KK, Wong AH. 2014. Association between air pollution and general outpatient clinic consultations for upper respiratory tract infections in Hong Kong. PLoS One. 9(1):e86913
  • Tang S, Yan Q, Shi W, Wang X, Sun X, Yu P, Wu J, Xiao Y. 2018. Measuring the impact of air pollution on respiratory infection risk in China. Environ Pollut. 232:477–486.
  • Terzano C, Di Stefano F, Conti V, Graziani E, Petroianni A. 2010. Air pollution ultrafine particles: toxicity beyond the lung. Eur Rev Med Pharmacol Sci. 14(10):809–821.
  • Tignat-Perrier R, Dommergue A, Thollot A, Keuschnig C, Magand O, Vogel TM, Larose C. 2019. Global airborne microbial communities controlled by surrounding landscapes and wind conditions. Sci Rep. 9(1):14441
  • Toro AR, Kvakić M, Klaić ZB, Koračin D, Morales SRGE, Leiva GMA. 2019. Exploring atmospheric stagnation during a severe particulate matter air pollution episode over complex terrain in Santiago, Chile. Environ Pollut. 244:705–714.
  • Torres A, Blasi F, Peetermans WE, Viegi G, Welte T. 2014. The aetiology and antibiotic management of community-acquired pneumonia in adults in Europe: a literature review. Eur J Clin Microbiol Infect Dis. 33(7):1065–1079.
  • United States Environmental Protection Agency. Criteria Air Pollutants. [date unknown]. https://www.epa.gov/criteria-air-pollutants.
  • United States Environmental Protection Agency. Particulate Matter Pollution. https://www.epa.gov/pm-pollution/particulate-matter-pm-basics#PM.
  • Vaïtilingom M, Amato P, Sancelme M, Laj P, Leriche M, Delort AM. 2010. Contribution of microbial activity to carbon chemistry in clouds. Appl Environ Microbiol. 76(1):23–29.
  • Valavanidis A, Fiotakis K, Bakeas E, Vlahogianni T. 2005. Electron paramagnetic resonance study of the generation of reactive oxygen species catalysed by transition metals and quinoid redox cycling by inhalable ambient particulate matter. Redox Rep. 10(1):37–51.
  • VanDevanter DR, Kahle JS, O'Sullivan AK, Sikirica S, Hodgkins PS. 2016. Cystic fibrosis in young children: A review of disease manifestation, progression, and response to early treatment. J Cyst Fibros. 15(2):147–157.
  • Wang H, Tian C, Wang W, Luo X. 2019. Temporal Cross-Correlations between Ambient Air Pollutants and Seasonality of Tuberculosis: A Time-Series Analysis. IJERPH. 16(9):1585.
  • Wang L, Cheng H, Wang D, Zhao B, Zhang J, Cheng L, Yao P, Di Narzo A, Shen Y, Yu J, et al. 2019. Airway microbiome is associated with respiratory functions and responses to ambient particulate matter exposure. Ecotoxicol Environ Saf. 167:269–277.
  • Wang T, Chiang ET, Moreno-Vinasco L, Lang GD, Pendyala S, Samet JM, Geyh AS, Breysse PN, Chillrud SN, Natarajan V, et al. 2010. Particulate matter disrupts human lung endothelial barrier integrity via ROS- and p38 MAPK-dependent pathways. Am J Respir Cell Mol Biol. 42(4):442–449.
  • Wang T, Wang L, Moreno-Vinasco L, Lang GD, Siegler JH, Mathew B, Usatyuk PV, Samet JM, Geyh AS, Breysse PN, et al. 2012. Particulate matter air pollution disrupts endothelial cell barrier via calpain-mediated tight junction protein degradation. Part Fibre Toxicol. 9:35
  • Wang XK, Lu WZ. 2006. Seasonal variation of air pollution index: Hong Kong case study. Chemosphere. 63(8):1261–1272.
  • Wei M, Xu C, Xu X, Zhu C, Li J, Lv G. 2019. Characteristics of atmospheric bacterial and fungal communities in PM2.5 following biomass burning disturbance in a rural area of North China Plain. Sci Total Environ. 651(Pt 2):2727–2739.
  • WHO 2016a. Air pollution. URL https://www.who.int/healthtopics/air-pollution#tab=tab_1.
  • WHO 2016b. Global Health Observatory (GHO) data: ambient air pollution. URL http://www.who.int/gho/phe/outdoor_air_pollution/en/.
  • World Health Organization 2016c. Ambient air pollution: A global assessment of exposure and burden of disease. Eds.: World Health Organization.
  • Xing YF, Xu YH, Shi MH, Lian YX. 2016. The impact of PM2.5 on the human respiratory system. J Thorac Dis. 8(1):E69–E74.
  • Xu C, Wei M, Chen J, Wang X, Zhu C, Li J, Zheng L, Sui G, Li W, Wang W, et al. 2017. Bacterial characterization in ambient submicron particles during severe haze episodes at Ji'nan, China. Sci Total Environ. 580:188–196.
  • Xu M, Li F, Wang M, Zhang H, Xu L, Adcock IM, Chung KF, Zhang Y. 2019. Protective effects of VGX-1027 in PM2.5-induced airway inflammation and bronchial hyperresponsiveness. Eur J Pharmacol. 842:373–383.
  • Xu M, Liao J, Yin P, Hou J, Zhou Y, Huang J, Liu B, Chen R, Ke L, Chen H, et al. 2019. Association of air pollution with the risk of initial outpatient visits for tuberculosis in Wuhan, China. Occup Environ Med. 76(8):560–566.
  • Xu Q, Li X, Wang S, Wang C, Huang F, Gao Q, Wu L, Tao L, Guo J, Wang W, et al. 2016. Fine particulate air pollution and hospital emergency room visits for respiratory disease in urban areas in Beijing, China, in 2013. PLoS One. 11(4):e0153099
  • Yadav MK, Go YY, Jun I, Chae SW, Song JJ. 2020. Urban particles elevated streptococcus pneumoniae biofilms, colonization of the human middle ear epithelial cells, mouse nasopharynx and transit to the middle ear and lungs. Sci Rep. 10(1):5969.
  • Yang J, Huo T, Zhang X, Ma J, Wang Y, Dong F, Deng J. 2018. Oxidative stress and cell cycle arrest induced by short-term exposure to dustfall PM2.5 in A549 cells. Environ Sci Pollut Res Int. 25(23):22408–22419.
  • Yao L, LiangLiang C, JinYue L, WanMei S, Lili S, YiFan L, HuaiChen L. 2019. Ambient air pollution exposures and risk of drug-resistant tuberculosis. Environ Int. 124:161–169.
  • Yao Q, Liu ZR, Han SQ, Cai ZY, Liu JL, Huang XJ, Liu JY, Wang YS. 2017. [Characteristics of the Size Distribution of Water-soluble Ions During a Heavy Pollution Episode in the Winter in Tianjin] . Huan Jing Ke Xue. 38(12):4958–4967.
  • Zhang D, Li Y, Chen Q, Jiang Y, Chu C, Ding Y, Yu Y, Fan Y, Shi J, Luo Y, et al. 2019. The relationship between air quality and respiratory pathogens among children in Suzhou City. Ital J Pediatr. 45(1):123
  • Zhou H, Kobzik L. 2007. Effect of concentrated ambient particles on macrophage phagocytosis and killing of Streptococcus pneumoniae. Am J Respir Cell Mol Biol. 36(4):460–465.
  • Zhu Y, Yang L, Chen J, Wang X, Xue L, Sui X, Wen L, Xu C, Yao L, Zhang J, et al. 2016. Characteristics of ambient volatile organic compounds and the influence of biomass burning at a rural site in Northern China during summer 2013. Atmos Environ. 124:15.

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