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Review Articles

Rotavirus-related systemic diseases: clinical manifestation, evidence and pathogenesis

, , , , , , , & ORCID Icon show all
Pages 580-595 | Received 07 Nov 2020, Accepted 16 Mar 2021, Published online: 06 Apr 2021

References

  • Ai Q, Yin J, Chen S, Qiao L, Luo N. 2016. Rotavirus-associated immune thrombocytopenic purpura in children: a retrospective study. Exp Ther Med. 12:2187–2190.
  • Aliabadi N, Antoni S, Mwenda JM, Weldegebriel G, Biey JNM, Cheikh D, Fahmy K, Teleb N, Ashmony HA, Ahmed H, et al. 2019. Global impact of rotavirus vaccine introduction on rotavirus hospitalisations among children under 5 years of age, 2008-16: findings from the Global Rotavirus Surveillance Network. Lancet Glob Health. 7:e893–e903.
  • Allen SR, Jafri M, Donnelly B, McNeal M, Witte D, Bezerra J, Ward R, Tiao GM. 2007. Effect of rotavirus strain on the murine model of biliary atresia. J Virol. 81:1671–1679.
  • Ashida A, Fujieda M, Ohta K, Nakakura H, Matsumura H, Morita T, Igarashi T, Tamai H. 2012. Clinical characteristics of obstructive uropathy associated with rotavirus gastroenteritis in Japan. Clin Nephrol. 77:49–54.
  • Azevedo MS, Yuan L, Jeong KI, Gonzalez A, Nguyen TV, Pouly S, Gochnauer M, Zhang W, Azevedo A, Saif LJ, et al. 2005. Viremia and nasal and rectal shedding of rotavirus in gnotobiotic pigs inoculated with Wa human rotavirus. J Virol. 79:5428–5436.
  • Bányai K, Estes MK, Martella V, Parashar UD. 2018. Viral gastroenteritis. Lancet. 392:175–186.
  • Baqui AH, Black RE, El Arifeen S, Yunus M, Chakraborty J, Ahmed S, Vaughan JP. 2002. Effect of zinc supplementation started during diarrhoea on morbidity and mortality in Bangladeshi children: community randomised trial. BMJ. 325:1059.
  • Basturk A, Artan R, Yilmaz A. 2017. Rotavirus gastroenteritis and a rare case accompanying acute pancreatitis. Prz Gastroenterol. 12:68–69.
  • Bednarek J, Traxinger B, Brigham D, Roach J, Orlicky D, Wang D, Pelanda R, Mack CL. 2018. Cytokine-producing B cells promote immune-mediated bile duct injury in murine biliary atresia. Hepatology. 68:1890–1904.
  • Bezerra JA, Tiao G, Ryckman FC, Alonso M, Sabla GE, Shneider B, Sokol RJ, Aronow BJ. 2002. Genetic induction of proinflammatory immunity in children with biliary atresia. Lancet. 360:1653–1659.
  • Biggart R, Finn A, Marlow R. 2018. Lack of impact of rotavirus vaccination on childhood seizure hospitalizations in England – an interrupted time series analysis. Vaccine. 36:4589–4592.
  • Blutt SE, Conner ME. 2007. Rotavirus: to the gut and beyond! Curr Opin Gastroenterol. 23:39–43.
  • Blutt SE, Kirkwood CD, Parreño V, Warfield KL, Ciarlet M, Estes MK, Bok K, Bishop RF, Conner ME. 2003. Rotavirus antigenaemia and viraemia: a common event? Lancet. 362:1445–1449.
  • Blutt SE, Matson DO, Crawford SE, Staat MA, Azimi P, Bennett BL, Piedra PA, Conner ME. 2007. Rotavirus antigenemia in children is associated with viremia. PLoS Med. 4:e121.
  • Brouard J, Freymuth F, Vabret A, et al. 2000. Viral co-infections in immunocompetent infants with bronchiolitis: prospective epidemiologic study] Co-infections virales lors des bronchiolites du nourrisson immunocompétent: étude prospective épidémiologique. Arch Pediatr. 7:531s–535s.
  • Burke RM, Tate JE, Dahl RM, Aliabadi N, Parashar UD. 2018. Rotavirus vaccination is associated with reduced seizure hospitalization risk among commercially insured US children. Clin Infect Dis. 67:1614–1616.
  • Burke RM, Tate JE, Dahl RM, Saydah S, Imperatore G, Gregg EW, Parashar UD. 2020. Rotavirus Vaccination and Type 1 Diabetes Risk Among US Children With Commercial Insurance. JAMA Pediatr. 174:383–385.
  • Burke RM, Tate JE, Jiang B, et al. 2020. Rotavirus and type 1 diabetes-is there a connection? A synthesis of the evidence. J Infect Dis. 222:1076–1083.
  • Burke RM, Tate JE, Kirkwood CD, Steele AD, Parashar UD. 2019. Current and new rotavirus vaccines. Curr Opin Infect Dis. 32:435–444.
  • Burnett E, Parashar UD, Tate JE. 2020. Associations of intussusception with adenovirus, rotavirus, and other pathogens: a review of the literature. Pediatr Infect Dis J. 39:1127–1130.
  • Burnett E, Parashar UD, Tate JE. 2020. Real-world effectiveness of rotavirus vaccines, 2006-19: a literature review and meta-analysis. Lancet Glob Health. 8:e1195–e1202.
  • Chen S, Li P, Wang Y, Yin Y, de Ruiter PE, Verstegen MMA, Peppelenbosch MP, van der Laan LJW, Pan Q. 2020. Rotavirus infection and cytopathogenesis in human biliary organoids potentially recapitulate biliary atresia development. mBio. 11:e01968-20.
  • Chen SM, Lin CP, Tsai JD, Chao YH, Sheu JN. 2014. The significance of serum and fecal levels of interleukin-6 and interleukin-8 in hospitalized children with acute rotavirus and norovirus gastroenteritis. Pediatr Neonatol. 55:120–126.
  • Cioc AM, Nuovo GJ. 2002. Histologic and in situ viral findings in the myocardium in cases of sudden, unexpected death. Mod Pathol. 15:914–922.
  • Coffin SE, Clark SL. 2001. Induction of intestinal rotavirus-specific antibodies in respiratory, but not gut, lymphoid tissues following mucosal immunization of mice with inactivated rotavirus. Virology. 291:235–240.
  • Colbère-Garapin F, Martin-Latil S, Blondel B, Mousson L, Pelletier I, Autret A, François A, Niborski V, Grompone G, Catonnet G, et al. 2007. Prevention and treatment of enteric viral infections: possible benefits of probiotic bacteria. Microbes Infect. 9:1623–1631.
  • Coulson BS, Witterick PD, Tan Y, Hewish MJ, Mountford JN, Harrison LC, Honeyman MC. 2002. Growth of rotaviruses in primary pancreatic cells. J Virol. 76:9537–9544.
  • Crawford SE, Patel DG, Cheng E, Berkova Z, Hyser JM, Ciarlet M, Finegold MJ, Conner ME, Estes MK. 2006. Rotavirus viremia and extraintestinal viral infection in the neonatal rat model. J Virol. 80:4820–4832.
  • Crawford SE, Ramani S, Tate JE, Parashar UD, Svensson L, Hagbom M, Franco MA, Greenberg HB, O'Ryan M, Kang G, et al. 2017. Rotavirus infection. Nat Rev Dis Primers. 3:17083–17083.
  • Czech-Schmidt G, Verhagen W, Szavay P, Leonhardt J, Petersen C. 2001. Immunological gap in the infectious animal model for biliary atresia. J Surg Res. 101:62–67.
  • Dalgic N, Sancar M, Bayraktar B, Pullu M, Hasim O. 2011. Probiotic, zinc and lactose-free formula in children with rotavirus diarrhea: are they effective? Pediatr Int. 53:677–682.
  • Dharakul T, Riepenhoff-Talty M, Albini B, Ogra PL. 1988. Distribution of rotavirus antigen in intestinal lymphoid tissues: potential role in development of the mucosal immune response to rotavirus. Clin Exp Immunol. 74:14–19.
  • DiFazio MP, Braun L, Freedman S, Hickey P. 2007. Rotavirus-induced seizures in childhood. J Child Neurol. 22:1367–1370.
  • Esona MD, Gautam R. 2015. Rotavirus. Clin Lab Med. 35:363–391.
  • Fenaux M, Cuadras MA, Feng N, Jaimes M, Greenberg HB. 2006. Extraintestinal spread and replication of a homologous EC rotavirus strain and a heterologous rhesus rotavirus in BALB/c mice. JVI. 80:5219–5232.
  • Filippi CM, von Herrath MG. 2008. Viral trigger for type 1 diabetes: pros and cons. Diabetes. 57:2863–2871.
  • Fragoso M, Kumar A, Murray DL. 1986. Rotavirus in nasopharyngeal secretions of children with upper respiratory tract infections. Diagn Microbiol Infect Dis. 4:87–88.
  • Fujinaga S, Kaneko K, Ohtomo Y, Takada M, Kobayashi K, Tada M, Yamashiro Y. 2005. Acute renal failure due to obstructive uric acid stones associated with rotavirus gastroenteritis. Pediatr Nephrol. 20:239–240.
  • Fukuda S, Kishi K, Yasuda K, Sejima H, Yamaguchi S. 2009. Rotavirus-associated encephalopathy with a reversible splenial lesion. Pediatric Neurology. 40:131–133.
  • Gilger MA, Matson DO, Conner ME, Rosenblatt HM, Finegold MJ, Estes MK. 1992. Extraintestinal rotavirus infections in children with immunodeficiency. J Pediatr. 120:912–917.
  • Glanz JM, Clarke CL, Xu S, Daley MF, Shoup JA, Schroeder EB, Lewin BJ, McClure DL, Kharbanda E, Klein NP, et al. 2020. Association between rotavirus vaccination and type 1 diabetes in children. JAMA Pediatr. 174:455–462.
  • Goldwater PN, Chrystie IL, Banatvala JE. 1979. Rotaviruses and the respiratory tract. Br Med J. 2:1551.
  • Goldwater PN, Rowland K, Thesinger M, Abbott K, Grieve A, Palombo EA, Masendycz PJ, Wilkinson I, Bear J. 2001. Rotavirus encephalopathy: pathogenesis reviewed. J Paediatr Child Health. 37:206–209.
  • Gómez-Rial J, Rivero-Calle I, Salas A, Martinón-Torres F. 2020. Rotavirus and autoimmunity. J Infect. 81:183–189.
  • Gómez-Rial J, Sánchez-Batán S, Rivero-Calle I, Pardo-Seco J, Martinón-Martínez JM, Salas A, Martinón-Torres F. 2019. Rotavirus infection beyond the gut. Infect Drug Resist. 12:55–64.
  • Graham KL, O'Donnell JA, Tan Y, Sanders N, Carrington EM, Allison J, Coulson BS. 2007. Rotavirus infection of infant and young adult nonobese diabetic mice involves extraintestinal spread and delays diabetes onset. J Virol. 81:6446–6458.
  • Graham KL, Sanders N, Tan Y, Allison J, Kay TWH, Coulson BS. 2008. Rotavirus infection accelerates type 1 diabetes in mice with established insulitis. JVI. 82:6139–6149.
  • Grech V, Calvagna V, Falzon A, Mifsud A. 2001. Fatal, rotavirus-associated myocarditis and pneumonitis in a 2-year-old boy. Ann Trop Paediatr. 21:147–148.
  • Greenberg HB, Clark HF, Offit PA. 1994. Rotavirus pathology and pathophysiology. Curr Top Microbiol Immunol. 185:255–283.
  • Grimprel E, Rodrigo C, Desselberger U. 2008. Rotavirus disease: impact of coinfections. Pediatr Infect Dis J. 27:S3–S10.
  • Gurwith M, Wenman W, Hinde D, Feltham S, Greenberg H. 1981. A prospective study of rotavirus infection in infants and young children. J Infect Dis. 144:218–224.
  • Haffejee IE, Moosa A. 1990. Rotavirus studies in Indian (Asian) South African infants with acute gastro-enteritis: II. Clinical aspects and outcome. Ann Trop Paediatr. 10:245–254.
  • Hagbom M, De Faria FM, Winberg ME, Westerberg S, Nordgren J, Sharma S, Keita ÅV, Loitto V, Magnusson KE, Svensson L, et al. 2020. Neurotrophic factors protect the intestinal barrier from rotavirus insult in mice. mBio. 11:31964731.
  • Hagbom M, Istrate C, Engblom D, Karlsson T, Rodriguez-Diaz J, Buesa J, Taylor JA, Loitto VM, Magnusson KE, Ahlman H, et al. 2011. Rotavirus stimulates release of serotonin (5-HT) from human enterochromaffin cells and activates brain structures involved in nausea and vomiting. PLoS Pathog. 7:e1002115.
  • Hagbom M, Sharma S, Lundgren O, Svensson L. 2012. Towards a human rotavirus disease model. Curr Opin Virol. 2:408–418.
  • Hagbom M, Svensson L, et al. 2016. Chapter 2.6 – Rotavirus disease mechanisms. In: Svensson L, Desselberger U, Greenberg HB, editors. Viral gastroenteritis. Boston (MA): Academic Press; p. 189–218.
  • Hagbom M, Svensson L. 2016. Rotavirus disease mechanisms. In: Svensson L, Desselberger U, Greenberg HB, Estes MK, editors. Viral gastroenteritis. London (UK): Academic Press; p. 189–218.
  • Hartman S, Brown E, Loomis E, Russell HA. 2019. Gastroenteritis in children. Am Fam Physician. 99:159–165.
  • Hemming-Harlo M, Lähdeaho ML, Mäki M, Vesikari T. 2019. Rotavirus vaccination does not increase type 1 diabetes and may decrease celiac disease in children and adolescents. Pediatr Infect Dis J. 38:539–541.
  • Herrmann B, Lawrenz-Wolf B, Seewald C, et al. 1993. [5th day convulsions of the newborn infant in rotavirus infections] 5-Tages-Krämpfe des Neugeborenen bei Rotavirusinfektionen. Monatsschr Kinderheilkd. 141:120–123.
  • Hertel PM, Estes MK. 2012. Rotavirus and biliary atresia: can causation be proven? Curr Opin Gastroenterol. 28:10–17.
  • Hjelt K, Krasilnikoff PA, Grauballe PC, Rasmussen SW. 1985. Clinical features in hospitalised children with acute gastroenteritis. Does the rotavirus syndrome exist? Acta Paediatr Scand. 74:96–101.
  • Honeyman MC, Laine D, Zhan Y, Londrigan S, Kirkwood C, Harrison LC. 2014. Rotavirus infection induces transient pancreatic involution and hyperglycemia in weanling mice. PLoS One. 9:e106560.
  • Hongou K, Konishi T, Yagi S, Araki K, Miyawaki T. 1998. Rotavirus encephalitis mimicking afebrile benign convulsions in infants. Pediatr Neurol. 18:354–357.
  • Hyser JM, Collinson-Pautz MR, Utama B, Estes MK. 2010. Rotavirus disrupts calcium homeostasis by NSP4 viroporin activity. mBio. 1:e00265-10.
  • Hyser JM, Utama B, Crawford SE, Estes MK. 2012. Genetic divergence of rotavirus nonstructural protein 4 results in distinct serogroup-specific viroporin activity and intracellular punctate structure morphologies. J Virol. 86:4921–4934.
  • Istrate C, Hagbom M, Vikström E, Magnusson KE, Svensson L. 2014. Rotavirus infection increases intestinal motility but not permeability at the onset of diarrhea. J Virol. 88:3161–3169.
  • Iturriza-Gómara M, Auchterlonie IA, Zaw W, Molyneaux P, Desselberger U, Gray J. 2002. Rotavirus gastroenteritis and central nervous system (CNS) infection: characterization of the VP7 and VP4 genes of rotavirus strains isolated from paired fecal and cerebrospinal fluid samples from a child with CNS disease. J Clin Microbiol. 40:4797–4799.
  • Janke BH, Morehouse LG, Solorzano RF. 1988. Single and mixed infections of neonatal pigs with rotaviruses and enteroviruses: virological studies. Can J Vet Res. 52:360–363.
  • Karampatsas K, Spyridou C, Morrison IR, Tong CYW, Prendergast AJ. 2015. Rotavirus-associated mild encephalopathy with a reversible splenial lesion (MERS)-case report and review of the literature. BMC Infect Dis. 15:446.
  • Kashyap G, Singh R, Malik YS, Agrawal RK, Singh KP, Kumar P, Sahoo M, Gupta D, Singh R. 2018. Experimental bovine rotavirus-A (RV-A)infection causes intestinal and extra-intestinal pathology in suckling mice. Microb Pathog. 121:22–26.
  • Keidan I, Shif I, Keren G, Passwell JH. 1992. Rotavirus encephalopathy: evidence of central nervous system involvement during rotavirus infection. Pediatr Infect Dis J. 11:773–775.
  • Kim HJ, Park JG, Matthijnssens J, Lee JH, Bae YC, Alfajaro MM, Park SI, Kang MI, Cho KO. 2011. Intestinal and extra-intestinal pathogenicity of a bovine reassortant rotavirus in calves and piglets. Vet Microbiol. 152:291–303.
  • Kira S, Mitsui T, Zakoji H, Aoki T, Sawada N, Miyamoto T, Takeda M. 2016. Postrenal failure due to urinary stones associated with acute viral gastroenteritis: three case reports. Case Rep Urol. 2016:1375923.
  • Köhler T, Erben U, Wiedersberg H, et al. 1990. [Histological findings of the small intestinal mucosa in rotavirus infections in infants and young children] Histologische Befunde der Dünndarmschleimhaut bei Rotavirusinfektionen im Säuglings- und Kleinkindalter. Kinderarztl Prax. 58:323–327.
  • Kordasti S, Sjövall H, Lundgren O, et al. 2004. Serotonin and vasoactive intestinal peptide antagonists attenuate rotavirus diarrhoea. Gut. 53:952–957.
  • Kovacs A, Chan L, Hotrakitya C, Overturf G, Portnoy B. 1986. Serum transaminase elevations in infants with rotavirus gastroenteritis. J Pediatr Gastroenterol Nutr. 5:873–877.
  • Kraft LM. 1958. Observations on the control and natural history of epidemic diarrhea of infant mice (EDIM). Yale J Biol Med. 31:121–137.
  • Laizane G, Smane L, Nokalna I, Gardovska D, Feemster KA. 2019. Rotavirus-associated seizures and reversible corpus callosum lesion. Acta Med Litu. 26:113–117.
  • Leung AK, Kellner JD, Davies HD. 2005. Rotavirus gastroenteritis. Adv Ther. 22:476–487.
  • Li ST, Grossman DC, Cummings P. 2007. Loperamide therapy for acute diarrhea in children: systematic review and meta-analysis. PLoS Med. 4:e98.
  • Lloyd MB, Lloyd JC, Gesteland PH, Bale JF. 2010. Rotavirus gastroenteritis and seizures in young children. Pediatr Neurol. 42:404–408.
  • Lu HL, Ding Y, Goyal H, Xu HG. 2019. Association between rotavirus vaccination and risk of intussusception among neonates and infants: a systematic review and meta-analysis. JAMA Netw Open. 2:e1912458.
  • Lundgren O, Svensson L. 2001. Pathogenesis of rotavirus diarrhea. Microbes Infect. 3:1145–1156.
  • Lynch M, Lee B, Azimi P, Gentsch J, Glaser C, Gilliam S, Chang H‐GH, Ward R, Glass RI. 2001. Rotavirus and central nervous system symptoms: cause or contaminant? Case reports and review. Clin Infect Dis. 33:932–938.
  • Lynch M, Shieh WJ, Tatti K, Gentsch JR, Harris TF, Jiang B, Guarner J, Bresee JS, Greenwald M, Cullen S, et al. 2003. The pathology of rotavirus-associated deaths, using new molecular diagnostics. Clin Infect Dis. 37:1327–1333.
  • Mack CL, Tucker RM, Lu BR, Sokol RJ, Fontenot AP, Ueno Y, Gill RG. 2006. Cellular and humoral autoimmunity directed at bile duct epithelia in murine biliary atresia. Hepatology. 44:1231–1239.
  • Madi N, Al-Nakib W, Mustafa AS, Habibi N. 2018. Metagenomic analysis of viral diversity in respiratory samples from patients with respiratory tract infections in Kuwait. J Med Virol. 90:412–420.
  • Matthijnssens J, Ciarlet M, Heiman E, Arijs I, Delbeke T, McDonald SM, Palombo EA, Iturriza-Gómara M, Maes P, Patton JT, et al. 2008. Full genome-based classification of rotaviruses reveals a common origin between human Wa-Like and porcine rotavirus strains and human DS-1-like and bovine rotavirus strains. J Virol. 82:3204–3219.
  • Mete E, Akelma AZ, Cizmeci MN, Bozkaya D, Kanburoglu MK. 2014. Decreased mean platelet volume in children with acute rotavirus gastroenteritis. Platelets. 25:51–54.
  • Miyata R, Tanuma N, Hayashi M, Imamura T, Takanashi JI, Nagata R, Okumura A, Kashii H, Tomita S, Kumada S, et al. 2012. Oxidative stress in patients with clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS). Brain Dev. 34:124–127.
  • Mormile R. 2016. Severe gastroenteritis and acute pancreatitis following rotavirus infection in children: the age-related failure of IFN-γ? Immunol Lett. 175:58–59.
  • Mossel EC, Ramig RF. 2003. A lymphatic mechanism of rotavirus extraintestinal spread in the neonatal mouse. J Virol. 77:12352–12356.
  • Nakano I, Taniguchi K, Ishibashi-Ueda H, Maeno Y, Yamamoto N, Yui A, Komoto S, Wakata Y, Matsubara T, Ozaki N, et al. 2011. Sudden death from systemic rotavirus infection and detection of nonstructural rotavirus proteins. J Clin Microbiol. 49:4382–4385.
  • Nigro G. 1991. Pancreatitis with hypoglycemia-associated convulsions following rotavirus gastroenteritis. J Pediatr Gastroenterol Nutr. 12:280–282.
  • Nishimura S, Ushijima H, Nishimura S, Shiraishi H, Kanazawa C, Abe T, Kaneko K, Fukuyama Y. 1993. Detection of rotavirus in cerebrospinal fluid and blood of patients with convulsions and gastroenteritis by means of the reverse transcription polymerase chain reaction. Brain Dev. 15:457–459.
  • Operario DJ, Platts-Mills JA, Nadan S, Page N, Seheri M, Mphahlele J, Praharaj I, Kang G, Araujo IT, Leite JPG, et al. 2017. Etiology of severe acute watery diarrhea in children in the Global Rotavirus Surveillance Network using quantitative polymerase chain reaction. J Infect Dis. 216:220–227.
  • Orrico-Sánchez A, López-Lacort M, Muñoz-Quiles C, Díez-Domingo J. 2018. Lack of impact of rotavirus vaccines on seizure-related hospitalizations in children under 5 years old in Spain. Hum Vaccin Immunother. 14:1534–1538.
  • Osborne MP, Haddon SJ, Spencer AJ, Collins J, Starkey WG, Wallis TS, Clarke GJ, Worton KJ, Candy DC, Stephen J, et al. 1988. An electron microscopic investigation of time-related changes in the intestine of neonatal mice infected with murine rotavirus. J Pediatr Gastroenterol Nutr. 7:236–248.
  • Pager C, Steele D, Gwamanda P, Driessen M. 2000. A neonatal death associated with rotavirus infection–detection of rotavirus dsRNA in the cerebrospinal fluid. S Afr Med J. 90:364–365.
  • Pane JA, Coulson BS. 2015. Lessons from the mouse: potential contribution of bystander lymphocyte activation by viruses to human type 1 diabetes. Diabetologia. 58:1149–1159.
  • Pane JA, Webster NL, Zufferey C, Coulson BS. 2014. Rotavirus acceleration of murine type 1 diabetes is associated with increased MHC class I-restricted antigen presentation by B cells and elevated proinflammatory cytokine expression by T cells. Virus Res. 179:73–84.
  • Parashar UD, Nelson EA, Kang G. 2013. Diagnosis, management, and prevention of rotavirus gastroenteritis in children. BMJ. 347:f7204.
  • Pardo-Seco J, Cebey-López M, Martinón-Torres N, Salas A, Gómez-Rial J, Rodriguez-Tenreiro C, Martinón-Sánchez JM, Martinón-Torres F. 2015. Impact of rotavirus vaccination on childhood hospitalization for seizures. Pediatr Infect Dis J. 34:769–773.
  • Parri N, Innocenti L, Collini S, Bechi F, Mannelli F. 2010. Acute pancreatitis due to rotavirus gastroenteritis in a child. Pediatr Emerg Care. 26:592–593.
  • Payne DC, Baggs J, Zerr DM, Klein NP, Yih K, Glanz J, Curns AT, Weintraub E, Parashar UD. 2014. Protective association between rotavirus vaccination and childhood seizures in the year following vaccination in US children. Clin Infect Dis. 58:173–177.
  • Perrett KP, Jachno K, Nolan TM, Harrison LC. 2019. Association of rotavirus vaccination with the incidence of type 1 diabetes in children. JAMA Pediatr. 173:280–282.
  • Petersen C, Biermanns D, Kuske M, Schäkel K, Meyer-Junghänel L, Mildenberger H. 1997. New aspects in a murine model for extrahepatic biliary atresia. J Pediatr Surg. 32:1190–1195.
  • Ramani S, Crawford SE, Blutt SE, Estes MK. 2018. Human organoid cultures: transformative new tools for human virus studies. Curr Opin Virol. 29:79–86.
  • Ramig RF. 2004. Pathogenesis of intestinal and systemic rotavirus infection. J Virol. 78:10213–10220.
  • Ramig RF. 2007. Systemic rotavirus infection. Expert Rev anti Infect Ther. 5:591–612.
  • Rautanen T, Kurki S, Vesikari T. 1997. Randomised double blind study of hypotonic oral rehydration solution in diarrhoea. Arch Dis Child. 76:272–274.
  • Rewers M, Ludvigsson J. 2016. Environmental risk factors for type 1 diabetes. Lancet. 387:2340–2348.
  • Reynolds DJ, Hall GA, Debney TG, Parsons KR. 1985. Pathology of natural rotavirus infection in clinically normal calves. Res Vet Sci. 38:264–269.
  • Riepenhoff-Talty M, Gouvea V, Evans MJ, Svensson L, Hoffenberg E, Sokol RJ, Uhnoo I, Greenberg SJ, Schakel K, Zhaori G, et al. 1996. Detection of group C rotavirus in infants with extrahepatic biliary atresia. J Infect Dis. 174:8–15.
  • Riepenhoff-Talty M, Schaekel K, Clark HF, Mueller W, Uhnoo I, Rossi T, Fisher J, Ogra PL. 1993. Group A rotaviruses produce extrahepatic biliary obstruction in orally inoculated newborn mice. Pediatr Res. 33:394–399.
  • Robinson CG, Hernanz-Schulman M, Zhu Y, Griffin MR, Gruber W, Edwards KM. 2004. Evaluation of anatomic changes in young children with natural rotavirus infection: is intussusception biologically plausible? J Infect Dis. 189:1382–1387.
  • Rodriguez-Calvo T, Sabouri S, Anquetil F, von Herrath MG. 2016. The viral paradigm in type 1 diabetes: who are the main suspects? Autoimmun Rev. 15:964–969.
  • Rogers MAM, Basu T, Kim C. 2019. Lower incidence rate of type 1 diabetes after receipt of the rotavirus vaccine in the United States, 2001-2017. Sci Rep. 9:7727.
  • Rogers MAM, Kim C, Banerjee T, Lee JM. 2017. Fluctuations in the incidence of type 1 diabetes in the United States from 2001 to 2015: a longitudinal study. BMC Med. 15:199.
  • Santosham M, Yolken RH, Quiroz E, Dillman L, Oro G, Reeves WC, Sack RB. 1983. Detection of rotavirus in respiratory secretions of children with pneumonia. J Pediatr. 103:583–585.
  • Saxena K, Blutt SE, Ettayebi K, Zeng XL, Broughman JR, Crawford SE, Karandikar UC, Sastri NP, Conner ME, Opekun AR, et al. 2016. Human intestinal enteroids: a new model to study human rotavirus infection, host restriction, and pathophysiology. J Virol. 90:43–56.
  • Sharma R, Hudak ML, Premachandra BR, Stevens G, Monteiro CB, Bradshaw JA, Kaunitz AM, Hollister RA. 2002. Clinical manifestations of rotavirus infection in the neonatal intensive care unit. Pediatr Infect Dis J. 21:1099–1105.
  • Shaw DP, Morehouse LG, Solorzano RF. 1989. Rotavirus replication in colostrum-fed and colostrum-deprived pigs. Am J Vet Res. 50:1966–1970.
  • Shepherd RW, Butler DG, Cutz E, Gall DG, Hamilton JR. 1979. The mucosal lesion in viral enteritis. Extent and dynamics of the epithelial response to virus invasion in transmissible gastroenteritis of piglets. Gastroenterology. 76:770–777.
  • Shirasu A, Ashida A, Matsumura H, Nakakura H, Tamai H. 2015. Clinical characteristics of rotavirus gastroenteritis with urinary crystals. Pediatr Int. 57:917–921.
  • Shivakumar P, Campbell KM, Sabla GE, Miethke A, Tiao G, McNeal MM, Ward RL, Bezerra JA. 2004. Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-gamma in experimental biliary atresia. J Clin Invest. 114:322–329.
  • Simsek C, Corman VM, Everling HU, Lukashev AN, Rasche A, Maganga GD, Binger T, Jansen D, Beller L, Deboutte W, et al. 2021. At least seven distinct rotavirus genotype constellations in bats with evidence of reassortment and zoonotic transmissions. mBio. 12:e02755-20.
  • Smatti MK, Cyprian FS, Nasrallah GK, Al Thani AA, Almishal RO, Yassine HM. 2019. Viruses and autoimmunity: a review on the potential interaction and molecular mechanisms. Viruses. 11:762.
  • Taboada B, Espinoza MA, Isa P, Aponte FE, Arias-Ortiz MA, Monge-Martínez J, Rodríguez-Vázquez R, Díaz-Hernández F, Zárate-Vidal F, Wong-Chew RM, et al. 2014. Is there still room for novel viral pathogens in pediatric respiratory tract infections? PLoS One. 9:e113570.
  • Takanashi J, Miyamoto T, Ando N, Kubota T, Oka M, Kato Z, Hamano S, Hirabayashi S, Kikuchi M, Barkovich AJ, et al. 2010. Clinical and radiological features of rotavirus cerebellitis. AJNR Am J Neuroradiol. 31:1591–1595.
  • Tanju C, Ekrem G, Berksoy Emel A, et al. 2014. Mean platelet volume as a negative marker of inflammation in children with rotavirus gastroenteritis. Iran J Pediatr. 24:617–622.
  • Tate JE, Burton AH, Boschi-Pinto C, et al. 2016. Global, regional, and national estimates of rotavirus mortality in children <5 years of age, 2000-2013. Clin Infect Dis. 62:S96–S105.
  • Tate JE, Burton AH, Boschi-Pinto C, Steele AD, Duque J, Parashar UD, WHO-coordinated Global Rotavirus Surveillance Network. 2012. 2008 estimate of worldwide rotavirus-associated mortality in children younger than 5 years before the introduction of universal rotavirus vaccination programmes: a systematic review and meta-analysis. Lancet Infect Dis. 12:136–141.
  • Teitelbaum JE, Daghistani R. 2007. Rotavirus causes hepatic transaminase elevation. Dig Dis Sci. 52:3396–3398.
  • Thi Kha Tu N, Thi Thu Hong N, Thi Han Ny N, My Phuc T, Thi Thanh Tam P, Doorn H. R v, Dang Trung Nghia H, Thao Huong D, An Han D, Thi Thu Ha L, et al. 2020. The virome of acute respiratory diseases in individuals at risk of zoonotic infections. Viruses. 12:960.
  • Trask SD, McDonald SM, Patton JT. 2012. Structural insights into the coupling of virion assembly and rotavirus replication. Nat Rev Microbiol. 10:165–177.
  • Troeger C, Khalil IA, Rao PC, Cao S, Blacker BF, Ahmed T, Armah G, Bines JE, Brewer TG, Colombara DV, et al. 2018. Rotavirus vaccination and the global burden of rotavirus diarrhea among children younger than 5 years. JAMA Pediatr. 172:958–965.
  • Tsukida K, Goto M, Yamaguchi N, Imagawa T, Tamura D, Yamagata T. 2018. Rotavirus gastroenteritis-associated urinary tract calculus in an infant. Turk J Pediatr. 60:769–770.
  • Uhnoo I, Riepenhoff-Talty M, Dharakul T, Chegas P, Fisher JE, Greenberg HB, Ogra PL. 1990. Extramucosal spread and development of hepatitis in immunodeficient and normal mice infected with rhesus rotavirus. J Virol. 64:361–368.
  • Ushijima H, Bosu K, Abe T, Shinozaki T. 1986. Suspected rotavirus encephalitis. Arch Dis Child. 61:692–694.
  • Vaarala O, Jokinen J, Lahdenkari M, Leino T. 2017. Rotavirus vaccination and the risk of celiac disease or type 1 diabetes in Finnish children at early life. Pediatr Infect Dis J. 36:674–675.
  • Van Den Brink GR, Bloemers SM, Van Den Blink B, Tertoolen LGJ, Van Deventer SJH, Peppelenbosch MP. 1999. Study of calcium signaling in non-excitable cells. Microsc Res Tech. 46:418–433.
  • Velázquez FR, Matson DO, Calva JJ, Guerrero L, Morrow AL, Carter-Campbell S, Glass RI, Estes MK, Pickering LK, Ruiz-Palacios GM, et al. 1996. Rotavirus infection in infants as protection against subsequent infections. N Engl J Med. 335:1022–1028.
  • Ward RL, Knowlton DR, Pierce MJ. 1984. Efficiency of human rotavirus propagation in cell culture. J Clin Microbiol. 19:748–753.
  • Ward RL, McNeal MM, Sheridan JF. 1990. Development of an adult mouse model for studies on protection against rotavirus. J Virol. 64:5070–5075.
  • Webster NL, Zufferey C, Pane JA, Coulson BS. 2013. Alteration of the thymic T cell repertoire by rotavirus infection is associated with delayed type 1 diabetes development in non-obese diabetic mice. PLoS One. 8:e59182.
  • Weclewicz K, Svensson L, Kristensson K. 1998. Targeting of endoplasmic reticulum-associated proteins to axons and dendrites in rotavirus-infected neurons. Brain Res Bull. 46:353–360.
  • Wong CJ, Price Z, Bruckner DA. 1984. Aseptic meningitis in an infant with rotavirus gastroenteritis. Pediatr Infect Dis. 3:244–246.
  • Wong V. 2001. Acute gastroenteritis-related encephalopathy. J Child Neurol. 16:906–910.
  • Yamashiro Y, Shimizu T, Oguchi S, Sato M. 1989. Prostaglandins in the plasma and stool of children with rotavirus gastroenteritis. J Pediatr Gastroenterol Nutr. 9:322–327.
  • Yeom JS, Jo JY, Park JS, Kim YS, Chung JY, Han TH, Seo JH, Park ES, Lim JY, Woo HO, et al. 2019. Monocyte chemoattractant protein (MCP)-1 in rotavirus-associated white matter injury in newborns. Neuropediatrics. 50:228–234.
  • Yeom JS, Park JS, Kim YS, Kim RB, Choi DS, Chung JY, Han TH, Seo JH, Park ES, Lim JY, et al. 2019. Neonatal seizures and white matter injury: role of rotavirus infection and probiotics. Brain Dev. 41:19–28.
  • Yolken R, Murphy M. 1982. Sudden infant death syndrome associated with rotavirus infection. J Med Virol. 10:291–296.
  • Yu TH, Tsai CN, Lai MW, Chen CC, Chao HC, Lin CW, Chiu CH, Chen SY. 2012. Antigenemia and cytokine expression in rotavirus gastroenteritis in children. J Microbiol Immunol Infect. 45:265–270.
  • Zhaori GT, Fu LT, Xu YH, Guo YR, Peng ZJ, Shan WS. 1991. Detection of rotavirus antigen in tracheal aspirates of infants and children with pneumonia. Chin Med J. 104:830–833.
  • Zheng BJ, Chang RX, Ma GZ, Xie JM, Liu Q, Liang XR, Ng MH. 1991. Rotavirus infection of the oropharynx and respiratory tract in young children. J Med Virol. 34:29–37.
  • Zheng J, Zheng H, Gupta RK, Li H, Shi H, Pan L, Gong S, Liang H. 2017. Interrelationship of rotavirus infection and Creatine Kinase-MB isoenzyme levels in children hospitalized with acute gastroenteritis in Guangzhou, China, 2012-2015. Sci Rep. 7:7674.