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Review Article

Non-antibiotic compounds associated with humans and the environment can promote horizontal transfer of antimicrobial resistance genes

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Received 08 Mar 2023, Accepted 30 Jun 2023, Published online: 18 Jul 2023

References

  • Acman M, Wang R, van Dorp L, Shaw LP, Wang Q, Luhmann N, Yin Y, Sun S, Chen H, Wang H, et al. 2022. Role of mobile genetic elements in the global dissemination of the carbapenem resistance gene blaNDM. Nat Commun. 13(1):1131. doi:10.1038/s41467-022-28819-2.
  • Ahmed MAE-GE-S, Yang Y, Yang Y, Yan B, Chen G, Hassan RM, Zhong L-L, Chen Y, Roberts AP, Wu Y, et al. 2021. Emergence of hypervirulent carbapenem-resistant Klebsiella pneumoniae coharboring a bla(NDM-1)-carrying virulent plasmid and a bla(KPC-2)-carrying plasmid in an Egyptian Hospital. mSphere. 6(3):1–6. doi:10.1128/mSphere.00088-21.
  • Al-Tohamy R, Ali SS, Li F, Okasha KM, Mahmoud YAG, Elsamahy T, Jiao H, Fu Y, Sun J. 2022. A critical review on the treatment of dye-containing wastewater: ecotoxicological and health concerns of textile dyes and possible remediation approaches for environmental safety. Ecotoxicol Environ Saf. 231:113160. doi:10.1016/j.ecoenv.2021.113160.
  • Alderton I, Palmer BR, Heinemann JA, Pattis I, Weaver L, Gutiérrez-Ginés MJ, Horswell J, Tremblay LA. 2021. The role of emerging organic contaminants in the development of antimicrobial resistance. Emerg Contaminants. 7:160–171. doi:10.1016/j.emcon.2021.07.001.
  • Arcari G, Carattoli A. 2022. Global spread and evolutionary convergence of multidrug-resistant and hypervirulent Klebsiella pneumoniae high-risk clones. Pathog Glob Health. 117(4):328–341.
  • Ares-Arroyo M, Fernandez-Garcia M, Wedel E, Montero N, Barbas C, Rey-Stolle MF, Garcia A, Gonzalez-Zorn B. 2022. Genomics, transcriptomics, and metabolomics reveal that minimal modifications in the host are crucial for the compensatory evolution of ColE1-like plasmids. mSphere. 7(6):e0018422. doi:10.1128/msphere.00184-22.
  • Arias-Andres M, Klumper U, Rojas-Jimenez K, Grossart HP. 2018. Microplastic pollution increases gene exchange in aquatic ecosystems. Environ Pollut. 237:253–261. doi:10.1016/j.envpol.2018.02.058.
  • Baharoglu Z, Bikard D, Mazel D. 2010. Conjugative DNA transfer induces the bacterial SOS response and promotes antibiotic resistance development through integron activation. PLoS Genet. 6(10):e1001165. doi:10.1371/journal.pgen.1001165.
  • Baig N, Kammakakam I, Falath W. 2021. Nanomaterials: a review of synthesis methods, properties, recent progress, and challenges. Mater Adv. 2(6):1821–1871. doi:10.1039/D0MA00807A.
  • Bandyopadhyay A, Ghoshal S, Mukherjee A. 2008. Genotoxicity testing of low-calorie sweeteners: aspartame, acesulfame-K, and saccharin. Drug Chem Toxicol. 31(4):447–457. doi:10.1080/01480540802390270.
  • Beaber JW, Hochhut B, Waldor MK. 2004. SOS response promotes horizontal dissemination of antibiotic resistance genes. Nature. 427(6969):72–74. doi:10.1038/nature02241.
  • Berge C, Waksman G, Terradot L. 2017. Structural and molecular biology of type IV secretion systems. Curr Top Microbiol Immunol. 413:31–60. doi:10.1007/978-3-319-75241-9_2.
  • Bertani B, Ruiz N. 2018. Function and biogenesis of lipopolysaccharides. EcoSal plus. 8(1):1–19. doi:10.1128/ecosalplus.ESP-0001-2018.
  • Biedrzycka M, Izdebski R, Urbanowicz P, Polańska M, Hryniewicz W, Gniadkowski M, Literacka E. 2022. MDR carbapenemase-producing Klebsiella pneumoniae of the hypervirulence-associated ST23 clone in Poland, 2009-19. J Antimicrob Chemother. 77(12):3367–3375. doi:10.1093/jac/dkac326.
  • Billane K, Harrison E, Cameron D, Brockhurst MA. 2022. Why do plasmids manipulate the expression of bacterial phenotypes? Philos Trans R Soc Lond B Biol Sci. 377(1842):20200461. doi:10.1098/rstb.2020.0461.
  • Bouet JY, Funnell BE. 2019. Plasmid localization and partition in Enterobacteriaceae. EcoSal plus. 8(2):1–23. doi:10.1128/ecosalplus.ESP-0003-2019.
  • Brett CN, Barnett SG, Pearson J. 2012. Postoperative plasma paracetamol levels following oral or intravenous paracetamol administration: a double-blind randomised controlled trial. Anaesth Intensive Care. 40(1):166–171. doi:10.1177/0310057X1204000121.
  • Brusselaers N. 2019. Prescribed drugs and the microbiome. Gastroenterol Clin North Am. 48(3):331–342. doi:10.1016/j.gtc.2019.04.002.
  • Buberg ML, Witso IL, L’Abee-Lund TM, Wasteson Y. 2020. Zinc and copper reduce conjugative transfer of resistance plasmids from extended-spectrum beta-lactamase-producing Escherichia coli. Microb Drug Resist. 26(7):842–849. doi:10.1089/mdr.2019.0388.
  • Buckner MMC, Ciusa ML, Piddock LJV. 2018. Strategies to combat antimicrobial resistance: anti-plasmid and plasmid curing. FEMS Microbiol Rev. 42(6):781–804. doi:10.1093/femsre/fuy031.
  • Buckner MMC, Ciusa ML, Meek RW, Moorey AR, McCallum GE, Prentice EL, Reid JP, Alderwick LJ, Di Maio A, Piddock LJV. 2020. HIV drugs inhibit transfer of plasmids carrying extended-spectrum beta-lactamase and carbapenemase genes. mBio. 11(1):1–18. doi:10.1128/mBio.03355-19.
  • Cabezon E, Ripoll-Rozada J, Pena A, de la Cruz F, Arechaga I. 2015. Towards an integrated model of bacterial conjugation. FEMS Microbiol Rev. 39(1):81–95. doi:10.1111/1574-6976.12085.
  • Camargo JF, Simkins J, Beduschi T, Tekin A, Aragon L, Pérez-Cardona A, Prado CE, Morris MI, Abbo LM, Cantón R. 2015. Successful treatment of carbapenemase-producing pandrug-resistant Klebsiella pneumoniae bacteremia. Antimicrob Agents Chemother. 59(10):5903–5908. doi:10.1128/AAC.00655-15.
  • Casu B, Smart J, Hancock MA, Smith M, Sygusch J, Baron C. 2016. Structural analysis and inhibition of TraE from the pKM101 type IV secretion system. J Biol Chem. 291(45):23817–23829. doi:10.1074/jbc.M116.753327.
  • Cen T, Zhang X, Xie S, Li D. 2020. Preservatives accelerate the horizontal transfer of plasmid-mediated antimicrobial resistance genes via differential mechanisms. Environ Int. 138:105544. doi:10.1016/j.envint.2020.105544.
  • Chassaing B, Compher C, Bonhomme B, Liu Q, Tian Y, Walters W, Nessel L, Delaroque C, Hao F, Gershuni V, et al. 2022. Randomized controlled-feeding study of dietary emulsifier carboxymethylcellulose reveals detrimental impacts on the gut microbiota and metabolome. Gastroenterology. 162(3):743–756. doi:10.1053/j.gastro.2021.11.006.
  • Chen J, McIlroy SE, Archana A, Baker DM, Panagiotou G. 2019. A pollution gradient contributes to the taxonomic, functional, and resistome diversity of microbial communities in marine sediments. Microbiome. 7(1):104. doi:10.1186/s40168-019-0714-6.
  • Chow LKM, Ghaly TM, Gillings MR. 2021. A survey of sub-inhibitory concentrations of antibiotics in the environment. J Environ Sci (China). 99:21–27. doi:10.1016/j.jes.2020.05.030.
  • Cousins IT, Ng CA, Wang Z, Scheringer M. 2019. Why is high persistence alone a major cause of concern? Environ Sci Process Impacts. 21(5):781–792. doi:10.1039/c8em00515j.
  • Cui Y, Gao J, Guo Y, Li Z, Wang Z, Zhao Y. 2022. Unraveling the impact and mechanism of antipyretic paracetamol on intergenera conjugative plasmid transfer. Environ Res. 215:114263. doi:10.1016/j.envres.2022.114263.
  • Darby EM, Trampari E, Siasat P, Gaya MS, Alav I, Webber MA, Blair JMA. 2023. Molecular mechanisms of antibiotic resistance revisited. Nat Rev Microbiol. 21(5):280–295. doi:10.1038/s41579-022-00820-y.
  • Davies NM, Anderson KE. 1997. Clinical pharmacokinetics of naproxen. Clin Pharmacokinet. 32(4):268–293. doi:10.2165/00003088-199732040-00002.
  • Dimitriu T. 2022. Evolution of horizontal transmission in antimicrobial resistance plasmids. Microbiology (Reading). 168(7):1–9. doi:10.1099/mic.0.001214.
  • Ding M, Ye Z, Liu L, Wang W, Chen Q, Zhang F, Wang Y, Sjöling Å, Martín-Rodríguez AJ, Hu R, et al. 2022a. Subinhibitory concentration antibiotic promotes horizontal transfer of plasmid-borne multi-antibiotic resistance genes with Klebsiella pneumonia and E. coli. Front Microbiol. 13:1–11. doi:10.3389/fmicb.2022.1017092.
  • Ding P, Lu J, Wang Y, Schembri MA, Guo J. 2022b. Antidepressants promote the spread of antibiotic resistance via horizontally conjugative gene transfer. Environmental Microbiology n/a. 24(11):5261–5276. doi:10.1111/1462-2920.16165.
  • Doi Y. 2019. Treatment options for carbapenem-resistant Gram-negative bacterial infections. Clin Infect Dis. 69(Suppl 7):S565–S575. doi:10.1093/cid/ciz830.
  • Duan W, Meng F, Wang F, Liu Q. 2017. Environmental behavior and eco-toxicity of xylene in aquatic environments: a review. Ecotoxicol Environ Saf. 145:324–332. doi:10.1016/j.ecoenv.2017.07.050.
  • Duke J, Guiney DG.Jr 1983. The role of lipopolysaccharide structure in the recipient cell during plasmid-mediated bacterial conjugation. Plasmid. 9(2):222–226. doi:10.1016/0147-619x(83)90024-0.
  • Dutta NK, Annadurai S, Mazumdar K, Dastidar SG, Kristiansen JE, Molnar J, Martins M, Amaral L. 2007. Potential management of resistant microbial infections with a novel non-antibiotic: the anti-inflammatory drug diclofenac sodium. Int J Antimicrob Agents. 30(3):242–249. doi:10.1016/j.ijantimicag.2007.04.018.
  • Element SJ, Moran RA, Beattie E, Hall RJ, van Schaik W, Buckner MMC. 2023. Growth in a biofilm promotes conjugation of a blaNDM-1-bearing plasmid between Klebsiella pneumoniae strains. bioRxiv 2023.2001.2005.522703.
  • Fasnacht M, Polacek N. 2021. Oxidative stress in bacteria and the central dogma of molecular biology. Front Mol Biosci. 8:671037. doi:10.3389/fmolb.2021.671037.
  • Feng M, Ye C, Zhang S, Sharma VK, Manoli K, Yu X. 2022. Bisphenols promote the conjugative transfer of antibiotic resistance genes without damaging cell membrane. Environ Chem Lett. 20(3):1553–1560. doi:10.1007/s10311-022-01397-x.
  • Fowler D, Coyle M, Skiba U, Sutton MA, Cape JN, Reis S, Sheppard LJ, Jenkins A, Grizzetti B, Galloway JN, et al. 2013. The global nitrogen cycle in the twenty-first century. Philos Trans R Soc Lond B Biol Sci. 368(1621):20130164. doi:10.1098/rstb.2013.0164.
  • Garcia-Cazorla Y, Getino M, Sanabria-Rios DJ, Carballeira NM, de la Cruz F, Arechaga I, Cabezon E. 2018. Conjugation inhibitors compete with palmitic acid for binding to the conjugative traffic ATPase TrwD, providing a mechanism to inhibit bacterial conjugation. J Biol Chem. 293(43):16923–16930. doi:10.1074/jbc.RA118.004716.
  • Garcillan-Barcia MP, Jurado P, Gonzalez-Perez B, Moncalian G, Fernandez LA, de la Cruz F. 2007. Conjugative transfer can be inhibited by blocking relaxase activity within recipient cells with intrabodies. Mol Microbiol. 63(2):404–416. doi:10.1111/j.1365-2958.2006.05523.x.
  • Getino M, de la Cruz F. 2018. Natural and artificial strategies to control the conjugative transmission of plasmids. Microbiol Spectr. 6(1):1–25. doi:10.1128/microbiolspec.MTBP-0015-2016.
  • Getino M, Fernandez-Lopez R, Palencia-Gandara C, Campos-Gomez J, Sanchez-Lopez JM, Martinez M, Fernandez A, de la Cruz F. 2016. Tanzawaic acids, a chemically novel set of bacterial conjugation inhibitors. PLoS One. 11(1):e0148098. doi:10.1371/journal.pone.0148098.
  • Gillezeau C, van Gerwen M, Shaffer RM, Rana I, Zhang L, Sheppard L, Taioli E. 2019. The evidence of human exposure to glyphosate: a review. Environ Health. 18(1):2. doi:10.1186/s12940-018-0435-5.
  • Gomes IB, Maillard J-Y, Simões LC, Simões M. 2020. Emerging contaminants affect the microbiome of water systems—strategies for their mitigation. Npj Clean Water. 3(1):39. doi:10.1038/s41545-020-00086-y.
  • Goncharoff P, Saadi S, Chang CH, Saltman LH, Figurski DH. 1991. Structural, molecular, and genetic analysis of the kilA operon of broad-host-range plasmid RK2. J Bacteriol. 173(11):3463–3477. doi:10.1128/jb.173.11.3463-3477.1991.
  • Grohmann E, Christie PJ, Waksman G, Backert S. 2018. Type IV secretion in Gram-negative and Gram-positive bacteria. Mol Microbiol. 107(4):455–471. doi:10.1111/mmi.13896.
  • Gu D, Dong N, Zheng Z, Lin D, Huang M, Wang L, Chan EW-C, Shu L, Yu J, Zhang R, et al. 2018. A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study. Lancet Infect Dis. 18(1):37–46. doi:10.1016/S1473-3099(17)30489-9.
  • Gullberg E, Cao S, Berg OG, Ilbäck C, Sandegren L, Hughes D, Andersson DI. 2011. Selection of resistant bacteria at very low antibiotic concentrations. PLoS Pathog. 7(7):e1002158. doi:10.1371/journal.ppat.1002158.
  • He K, Xue B, Yang X, Wang S, Li C, Zhang X, Zhao C, Wang X, Qiu Z, Shen Z, et al. 2022. Low-concentration of trichloromethane and dichloroacetonitrile promote the plasmid-mediated horizontal transfer of antibiotic resistance genes. J Hazard Mater. 425:128030. doi:10.1016/j.jhazmat.2021.128030.
  • Helinski DR. 2022. A brief history of plasmids. EcoSal Plus. 10(1):eESP00282021. doi:10.1128/ecosalplus.ESP-0028-2021.
  • Hennequin C, Aumeran C, Robin F, Traore O, Forestier C. 2012. Antibiotic resistance and plasmid transfer capacity in biofilm formed with a CTX-M-15-producing Klebsiella pneumoniae isolate. J Antimicrob Chemother. 67(9):2123–2130. doi:10.1093/jac/dks169.
  • Hoekstra WPM, Havekes AM. 1979. On the role of the recipient cell during conjugation in Escherichia coli. Antonie Van Leeuwenhoek. 45(1):13–18. doi:10.1007/BF00400773.
  • Hooper DC, Wolfson JS, McHugh GL, Swartz MD, Tung C, Swartz MN. 1984. Elimination of plasmid pMG110 from Escherichia coli by novobiocin and other inhibitors of DNA gyrase. Antimicrob Agents Chemother. 25(5):586–590. doi:10.1128/AAC.25.5.586.
  • Hospenthal MK, Costa TRD, Waksman G. 2017. A comprehensive guide to pilus biogenesis in Gram-negative bacteria. Nat Rev Microbiol. 15(6):365–379. doi:10.1038/nrmicro.2017.40.
  • Huang H, Feng G, Wang M, Liu C, Wu Y, Dong L, Feng L, Zheng X, Chen Y. 2022. Nitric oxide: a neglected driver for the conjugative transfer of antibiotic resistance genes among wastewater microbiota. Environ Sci Technol. 56(10):6466–6478. doi:10.1021/acs.est.2c01889.
  • Huang YH, Chou SH, Liang SW, Ni CE, Lin YT, Huang YW, Yang TC. 2018. Emergence of an XDR and carbapenemase-producing hypervirulent Klebsiella pneumoniae strain in Taiwan. J Antimicrob Chemother. 73(8):2039–2046. doi:10.1093/jac/dky164.
  • Hunger M, Schmucker R, Kishan V, Hillen W. 1990. Analysis and nucleotide sequence of an origin of DNA replication in Acinetobacter calcoaceticus and its use for Escherichia coli shuttle plasmids. Gene. 87(1):45–51. doi:10.1016/0378-1119(90)90494-c.
  • Ilangovan A, Connery S, Waksman G. 2015. Structural biology of the Gram-negative bacterial conjugation systems. Trends Microbiol. 23(5):301–310. doi:10.1016/j.tim.2015.02.012.
  • Jia X, Zhu Y, Jia P, Liu X, Yu W, Li X, Xu Y, Yang Q. 2022. Emergence of a superplasmid coharboring hypervirulence and multidrug resistance genes in Klebsiella pneumoniae poses new challenges to public health. Microbiol Spectr. 10(6):e0263422. doi:10.1128/spectrum.02634-22.
  • Jia Y, Wang Z, Fang D, Yang B, Li R, Liu Y. 2021. Acetaminophen promotes horizontal transfer of plasmid-borne multiple antibiotic resistance genes. Sci Total Environ. 782:146916. doi:10.1016/j.scitotenv.2021.146916.
  • Jiao YN, Chen H, Gao RX, Zhu YG, Rensing C. 2017. Organic compounds stimulate horizontal transfer of antibiotic resistance genes in mixed wastewater treatment systems. Chemosphere. 184:53–61. doi:10.1016/j.chemosphere.2017.05.149.
  • Jin M, Yuan H, Liu B, Peng J, Xu L, Yang D. 2020. Review of the distribution and detection methods of heavy metals in the environment. Anal Methods. 12(48):5747–5766. doi:10.1039/d0ay01577f.
  • Johnson AP, Woodford N. 2013. Global spread of antibiotic resistance: the example of New Delhi metallo-beta-lactamase (NDM)-mediated carbapenem resistance. J Med Microbiol. 62(Pt 4):499–513. doi:10.1099/jmm.0.052555-0.
  • Johnston C, Martin B, Fichant G, Polard P, Claverys J-P. 2014. Bacterial transformation: distribution, shared mechanisms and divergent control. Nat Rev Microbiol. 12(3):181–196. doi:10.1038/nrmicro3199.
  • Joint Formulary Committee. 2022. British National Formulary (BNF84). UK: Pharmaceutical Press.
  • Jurėnas D, Fraikin N, Goormaghtigh F, Van Melderen L. 2022. Biology and evolution of bacterial toxin–antitoxin systems. Nat Rev Microbiol. 20(6):335–350. doi:10.1038/s41579-021-00661-1.
  • Kaur G, Kumar H, Singla M. 2022. Diverse applications of ionic liquids: a comprehensive review. J Mol Liquids. 351:118556. doi:10.1016/j.molliq.2022.118556.
  • Kessler C, Hou J, Neo O, Buckner MMC. 2023. In situ, in vivo, and in vitro approaches for studying AMR plasmid conjugation in the gut microbiome. FEMS Microbiology Reviews. 47(1):1–13. doi:10.1093/femsre/fuac044.
  • Klein EY, Van Boeckel TP, Martinez EM, Pant S, Gandra S, Levin SA, Goossens H, Laxminarayan R. 2018. Global increase and geographic convergence in antibiotic consumption between 2000 and 2015. Proc Natl Acad Sci U S A. 115(15):E3463–E3470. doi:10.1073/pnas.1717295115.
  • Kohler V, Keller W, Grohmann E. 2019. Regulation of gram-positive conjugation. Front Microbiol. 10:1134. doi:10.3389/fmicb.2019.01134.
  • Kopotsa K, Osei Sekyere J, Mbelle NM. 2019. Plasmid evolution in carbapenemase-producing Enterobacteriaceae: a review. Ann N Y Acad Sci. 1457(1):61–91. doi:10.1111/nyas.14223.
  • Koraimann G. 2018. Spread and persistence of virulence and antibiotic resistance genes: a ride on the F plasmid conjugation module. EcoSal plus. 8(1):1–23. doi:10.1128/ecosalplus.ESP-0003-2018.
  • Kothari A, Kumar P, Gaurav A, Kaushal K, Pandey A, Yadav SRM, Jain N, Omar BJ. 2023. Association of antibiotics and heavy metal arsenic to horizontal gene transfer from multidrug-resistant clinical strains to antibiotic-sensitive environmental strains. J Hazard Mater. 443(Pt B):130260. doi:10.1016/j.jhazmat.2022.130260.
  • Kraemer SA, Ramachandran A, Perron GG. 2019. Antibiotic pollution in the environment: from microbial ecology to public policy. Microorganisms. 7(6):180. doi:10.3390/microorganisms7060180.
  • Krasner SW. 2009. The formation and control of emerging disinfection by-products of health concern. Philos Trans A Math Phys Eng Sci. 367(1904):4077–4095. doi:10.1098/rsta.2009.0108.
  • Kumarasamy KK, Toleman MA, Walsh TR, Bagaria J, Butt F, Balakrishnan R, Chaudhary U, Doumith M, Giske CG, Irfan S, et al. 2010. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect Dis. 10(9):597–602. doi:10.1016/S1473-3099(10)70143-2.
  • Lam MMC, Wyres KL, Wick RR, Judd LM, Fostervold A, Holt KE, Lohr IH. 2019. Convergence of virulence and MDR in a single plasmid vector in MDR Klebsiella pneumoniae ST15. J Antimicrob Chemother. 74(5):1218–1222. doi:10.1093/jac/dkz028.
  • Larsson DGJ, Flach C-F. 2022. Antibiotic resistance in the environment. Nat Rev Microbiol. 20(5):257–269. doi:10.1038/s41579-021-00649-x.
  • Law Y, Ye L, Pan Y, Yuan Z. 2012. Nitrous oxide emissions from wastewater treatment processes. Philos Trans R Soc Lond B Biol Sci. 367(1593):1265–1277. doi:10.1098/rstb.2011.0317.
  • Li B, Qiu Y, Song Y, Lin H, Yin H. 2019. Dissecting horizontal and vertical gene transfer of antibiotic resistance plasmid in bacterial community using microfluidics. Environ Int. 131:105007. doi:10.1016/j.envint.2019.105007.
  • Li W, Zhang WG, Zhang MS, Lei ZF, Li PF, Ma Y, Gao Y. 2022. Environmentally relevant concentrations of mercury facilitate the horizontal transfer of plasmid-mediated antibiotic resistance genes. Sci Total Environ. 852:158272. doi:10.1016/j.scitotenv.2022.158272.
  • Li H, Dechesne A, He Z, Jensen MM, Song HL, Smets BF. 2023a. Electrochemical disinfection may increase the spread of antibiotic resistance genes by promoting conjugal plasmid transfer. Sci Total Environ. 858(Pt 1):159846. doi:10.1016/j.scitotenv.2022.159846.
  • Li X, Xue X, Jia J, Zou X, Guan Y, Zhu L, Wang Z. 2023b. Nonsteroidal anti-inflammatory drug diclofenac accelerates the emergence of antibiotic resistance via mutagenesis. Environ Pollut. 326:121457. doi:10.1016/j.envpol.2023.121457.
  • Liebert CA, Hall RM, Summers AO. 1999. Transposon Tn21, flagship of the floating genome. Microbiol Mol Biol Rev. 63(3):507–522. doi:10.1128/MMBR.63.3.507-522.1999.
  • Lin H, Jiang L, Li B, Dong Y, He Y, Qiu Y. 2019. Screening and evaluation of heavy metals facilitating antibiotic resistance gene transfer in a sludge bacterial community. Sci Total Environ. 695:133862. doi:10.1016/j.scitotenv.2019.133862.
  • Ling Z, Yin W, Shen Z, Wang Y, Shen J, Walsh TR. 2020. Epidemiology of mobile colistin resistance genes mcr-1 to mcr-9. J Antimicrob Chemother. 75(11):3087–3095. doi:10.1093/jac/dkaa205.
  • Liu J, Zhang L, Lu G, Jiang R, Yan Z, Li Y. 2021. Occurrence, toxicity and ecological risk of Bisphenol A analogues in aquatic environment - a review. Ecotoxicol Environ Saf. 208:111481. doi:10.1016/j.ecoenv.2020.111481.
  • Liu X, Khara P, Baker ML, Christie PJ, Hu B. 2022. Structure of a type IV secretion system core complex encoded by multi-drug resistance F plasmids. Nat Commun. 13(1):379. doi:10.1038/s41467-022-28058-5.
  • Liu Y, Tong Z, Shi J, Jia Y, Yang K, Wang Z. 2020. Correlation between exogenous compounds and the horizontal transfer of plasmid-borne antibiotic resistance genes. Microorganisms. 8(8):1211. doi:10.3390/microorganisms8081211.
  • Liu Y-Y, Wang Y, Walsh TR, Yi L-X, Zhang R, Spencer J, Doi Y, Tian G, Dong B, Huang X, et al. 2016. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis. 16(2):161–168. doi:10.1016/S1473-3099(15)00424-7.
  • Lopatkin AJ, Huang S, Smith RP, Srimani JK, Sysoeva TA, Bewick S, Karig DK, You L. 2016. Antibiotics as a selective driver for conjugation dynamics. Nat Microbiol. 1(6):16044. doi:10.1038/nmicrobiol.2016.44.
  • Low HH, Gubellini F, Rivera-Calzada A, Braun N, Connery S, Dujeancourt A, Lu F, Redzej A, Fronzes R, Orlova EV, et al. 2014. Structure of a type IV secretion system. Nature. 508(7497):550–553. doi:10.1038/nature13081.
  • Low WW, Wong JLC, Beltran LC, Seddon C, David S, Kwong H-S, Bizeau T, Wang F, Peña A, Costa TRD, et al. 2022. Mating pair stabilization mediates bacterial conjugation species specificity. Nat Microbiol. 7(7):1016–1027. doi:10.1038/s41564-022-01146-4.
  • Lu J, Ding P, Wang Y, Guo J. 2022a. Antidepressants promote the spread of extracellular antibiotic resistance genes via transformation. ISME Commun. 2(1):63. doi:10.1038/s43705-022-00147-y.
  • Lu X, Du Y, Peng K, Zhang W, Li J, Wang Z, Li R. 2022b. Coexistence of tet(X4), mcr-1, and blaNDM-5 in ST6775 Escherichia coli isolates of animal origin in China. Microbiol Spectr. 10(2):e0019622. doi:10.1128/spectrum.00196-22.
  • Lu Y, Zeng J, Wang L, Lan K, E S, Wang L, Xiao Q, Luo Q, Huang X, Huang B, et al. 2017. Antibiotics promote Escherichia coli-Pseudomonas aeruginosa conjugation through inhibiting quorum sensing. Antimicrob Agents Chemother. 61(12):1–7. doi:10.1128/AAC.01284-17.
  • Macé K, Vadakkepat AK, Redzej A, Lukoyanova N, Oomen C, Braun N, Ukleja M, Lu F, Costa TRD, Orlova EV, et al. 2022. Cryo-EM structure of a type IV secretion system. Nature. 607(7917):191–196. doi:10.1038/s41586-022-04859-y.
  • Mandi TY, Molnar J, Holland IB, Beladi I. 1975. Efficient curing of an Escherichia coli F-prime plasmid by phenothiazines. Genet Res. 26(1):109–111. doi:10.1017/s0016672300015895.
  • Mc Mahon MA, Blair IS, Moore JE, Mc Dowell DA. 2007. The rate of horizontal transmission of antibiotic resistance plasmids is increased in food preservation-stressed bacteria. J Appl Microbiol. 103(5):1883–1888. doi:10.1111/j.1365-2672.2007.03412.x.
  • McGovern AS, Hamlin AS, Winter G. 2019. A review of the antimicrobial side of antidepressants and its putative implications on the gut microbiome. Aust N Z J Psychiatry. 53(12):1151–1166. doi:10.1177/0004867419877954.
  • McHugh GL, Swartz MN. 1977. Elimination of plasmids from several bacterial species by novobiocin. Antimicrob Agents Chemother. 12(3):423–426. doi:10.1128/AAC.12.3.423.
  • McInnes RS, McCallum GE, Lamberte LE, van Schaik W. 2020. Horizontal transfer of antibiotic resistance genes in the human gut microbiome. Curr Opin Microbiol. 53:35–43. doi:10.1016/j.mib.2020.02.002.
  • McKenzie GJ, Harris RS, Lee PL, Rosenberg SM. 2000. The SOS response regulates adaptive mutation. Proc Natl Acad Sci U S A. 97(12):6646–6651. doi:10.1073/pnas.120161797.
  • Michel-Briand Y, Uccelli V, Laporte J-M, Plesiat P. 1986. Elimination of plasmids from Enterobacteriaceae by 4-quinolone derivatives. J Antimicrob Chemother. 18(6):667–674. doi:10.1093/jac/18.6.667.
  • Mohanalakshmi S, Bhatt S, Ashok Kumar CK. 2021. Enhanced antihyperlipidemic potential of gemfibrozil under co-administration with piperine. Curr Res Pharmacol Drug Discov. 2:100021. doi:10.1016/j.crphar.2021.100021.
  • Mohanraj RS, Mandal J. 2022. Azithromycin can induce SOS response and horizontal gene transfer of SXT element in Vibrio cholerae. Mol Biol Rep. 49(6):4737–4748. doi:10.1007/s11033-022-07323-2.
  • Moller TSB, Liu G, Boysen A, Thomsen LE, Luthje FL, Mortensen S, Moller-Jensen J, Olsen JE. 2017. Treatment with cefotaxime affects expression of conjugation associated proteins and conjugation transfer frequency of an IncI1 plasmid in Escherichia coli. Front Microbiol. 8:2365. doi:10.3389/fmicb.2017.02365.
  • Molnar J, Mandi Y, Kiraly J. 1976. Antibacterial effect of some phenothiazine compounds and R-factor elimination by chlorpromazine. Acta Microbiol Acad Sci Hung. 23:45–54.
  • Munoz-Bellido JL, Munoz-Criado S, Garcìa-Rodrìguez JA. 2000. Antimicrobial activity of psychotropic drugs: selective serotonin reuptake inhibitors. Int J Antimicrob Agents. 14(3):177–180. doi:10.1016/s0924-8579(99)00154-5.
  • Neil K, Allard N, Rodrigue S. 2021. Molecular mechanisms influencing bacterial conjugation in the intestinal microbiota. Front Microbiol. 12:673260. doi:10.3389/fmicb.2021.673260.
  • Nolen WA, Jansen GS, Broekman M. 1988. Measuring plasma levels of carbamazepine. A pharmacokinetic study in patients with affective disorders. Pharmacopsychiatry. 21(5):252–254. doi:10.1055/s-2007-1016965.
  • Norman A, Hansen LH, Sorensen SJ. 2009. Conjugative plasmids: vessels of the communal gene pool. Philos Trans R Soc Lond B Biol Sci. 364(1527):2275–2289. doi:10.1098/rstb.2009.0037.
  • Ott LC, Mellata M. 2022. Models for gut-mediated horizontal gene transfer by bacterial plasmid conjugation. Front Microbiol. 13:891548. doi:10.3389/fmicb.2022.891548.
  • Ou J, Elizalde P, Guo HB, Qin H, Tobe BTD, Choy JS. 2022. TCA and SSRI antidepressants exert selection pressure for efflux-dependent antibiotic resistance mechanisms in Escherichia coli. mBio. 13(6):e0219122. doi:10.1128/mbio.02191-22.
  • Pal C, Asiani K, Arya S, Rensing C, Stekel DJ, Larsson DGJ, Hobman JL. 2017. Metal resistance and its association with antibiotic resistance. Adv Microb Physiol. 70:261–313. doi:10.1016/bs.ampbs.2017.02.001.
  • Partridge SR, Kwong SM, Firth N, Jensen SO. 2018. Mobile genetic elements associated with antimicrobial resistance. Clin Microbiol Rev. 31(4):1–61. doi:10.1128/CMR.00088-17.
  • Patangia DV, Anthony Ryan C, Dempsey E, Paul Ross R, Stanton C. 2022. Impact of antibiotics on the human microbiome and consequences for host health. Microbiologyopen. 11(1):e1260. doi:10.1002/mbo3.1260.
  • Penders J, Stobberingh EE, Savelkoul PH, Wolffs PF. 2013. The human microbiome as a reservoir of antimicrobial resistance. Front Microbiol. 4:87. doi:10.3389/fmicb.2013.00087.
  • Peruzzo PJ, Porta AA, Ronco AE. 2008. Levels of glyphosate in surface waters, sediments and soils associated with direct sowing soybean cultivation in north pampasic region of Argentina. Environ Pollut. 156(1):61–66. doi:10.1016/j.envpol.2008.01.015.
  • Pilla G, Tang CM. 2018. Going around in circles: virulence plasmids in enteric pathogens. Nat Rev Microbiol. 16(8):484–495. doi:10.1038/s41579-018-0031-2.
  • Pu Q, Fan XT, Li H, An XL, Lassen SB, Su JQ. 2021. Cadmium enhances conjugative plasmid transfer to a fresh water microbial community. Environ Pollut. 268(Pt B):115903. doi:10.1016/j.envpol.2020.115903.
  • Qiu W, Zhan H, Hu J, Zhang T, Xu H, Wong M, Xu B, Zheng C. 2019. The occurrence, potential toxicity, and toxicity mechanism of bisphenol S, a substitute of bisphenol A: a critical review of recent progress. Ecotoxicol Environ Saf. 173:192–202. doi:10.1016/j.ecoenv.2019.01.114.
  • Qiu Z, Yu Y, Chen Z, Jin M, Yang D, Zhao Z, Wang J, Shen Z, Wang X, Qian D, et al. 2012. Nanoalumina promotes the horizontal transfer of multiresistance genes mediated by plasmids across genera. Proc Natl Acad Sci U S A. 109(13):4944–4949. doi:10.1073/pnas.1107254109.
  • Ramsay KA, McTavish SM, Wardell SJT, Lamont IL. 2021. The effects of sub-inhibitory antibiotic concentrations on Pseudomonas aeruginosa: reduced susceptibility due to mutations. Front Microbiol. 12:789550. doi:10.3389/fmicb.2021.789550.
  • Ribeiro E, Ladeira C, Viegas S. 2017. Occupational exposure to bisphenol A (BPA): a reality that still needs to be unveiled. Toxics. 5(3):22. doi:10.3390/toxics5030022.
  • Ripoll-Rozada J, Garcia-Cazorla Y, Getino M, Machon C, Sanabria-Rios D, de la Cruz F, Cabezon E, Arechaga I. 2016. Type IV traffic ATPase TrwD as molecular target to inhibit bacterial conjugation. Mol Microbiol. 100(5):912–921. doi:10.1111/mmi.13359.
  • Rosas NC, Lithgow T. 2022. Targeting bacterial outer-membrane remodelling to impact antimicrobial drug resistance. Trends Microbiol. 30(6):544–552. doi:10.1016/j.tim.2021.11.002.
  • Rozwandowicz M, Brouwer MSM, Fischer J, Wagenaar JA, Gonzalez-Zorn B, Guerra B, Mevius DJ, Hordijk J. 2018. Plasmids carrying antimicrobial resistance genes in Enterobacteriaceae. J Antimicrob Chemother. 73(5):1121–1137. doi:10.1093/jac/dkx488.
  • Rukavishnikov G, Leonova L, Kasyanov E, Leonov V, Neznanov N, Mazo G. 2023. Antimicrobial activity of antidepressants on normal gut microbiota: results of the in vitro study. Front Behav Neurosci. 17:1132127. doi:10.3389/fnbeh.2023.1132127.
  • Samuels AL, Lanka E, Davies JE. 2000. Conjugative junctions in RP4-mediated mating of Escherichia coli. J Bacteriol. 182(10):2709–2715. doi:10.1128/JB.182.10.2709-2715.2000.
  • San Millan A. 2018. Evolution of plasmid-mediated antibiotic resistance in the clinical context. Trends Microbiol. 26(12):978–985. doi:10.1016/j.tim.2018.06.007.
  • San Millan A, Toll-Riera M, Qi Q, Betts A, Hopkinson RJ, McCullagh J, MacLean RC. 2018. Integrative analysis of fitness and metabolic effects of plasmids in Pseudomonas aeruginosa PAO1. ISME J. 12(12):3014–3024. doi:10.1038/s41396-018-0224-8.
  • Sanchez-Cid C, Guironnet A, Keuschnig C, Wiest L, Vulliet E, Vogel TM. 2022. Gentamicin at sub-inhibitory concentrations selects for antibiotic resistance in the environment. ISME Commun. 2(1):29. doi:10.1038/s43705-022-00101-y.
  • Sanderson KE, Janzer J, Head J. 1981. Influence of lipopolysaccharide and protein in the cell envelope on recipient capacity in conjugation of Salmonella typhimurium. J Bacteriol. 148(1):283–293. doi:10.1128/jb.148.1.283-293.1981.
  • Seitz P, Blokesch M. 2013. Cues and regulatory pathways involved in natural competence and transformation in pathogenic and environmental Gram-negative bacteria. FEMS Microbiol Rev. 37(3):336–363. doi:10.1111/j.1574-6976.2012.00353.x.
  • Sengupta M, Austin S. 2011. Prevalence and significance of plasmid maintenance functions in the virulence plasmids of pathogenic bacteria. Infect Immun. 79(7):2502–2509. doi:10.1128/IAI.00127-11.
  • Shah PN, Marshall-Batty KR, Smolen JA, Tagaev JA, Chen Q, Rodesney CA, Le HH, Gordon VD, Greenberg DE, Cannon CL. 2018. Antimicrobial activity of ibuprofen against cystic fibrosis-associated gram-negative pathogens. Antimicrob Agents Chemother. 62(3):1–22. doi:10.1128/AAC.01574-17.
  • Shen Z, Tang CM, Liu G-Y. 2022. Towards a better understanding of antimicrobial resistance dissemination: what can be learnt from studying model conjugative plasmids? Mil Med Res. 9(1):3. doi:10.1186/s40779-021-00362-z.
  • Shun-Mei E, Zeng JM, Yuan H, Lu Y, Cai RX, Chen C. 2018. Sub-inhibitory concentrations of fluoroquinolones increase conjugation frequency. Microb Pathog. 114:57–62. doi:10.1016/j.micpath.2017.11.036.
  • Smillie C, Garcillan-Barcia MP, Francia MV, Rocha EP, de la Cruz F. 2010. Mobility of plasmids. Microbiol Mol Biol Rev. 74(3):434–452. doi:10.1128/MMBR.00020-10.
  • Sommer MOA, Dantas G, Church GM. 2009. Functional characterization of the antibiotic resistance reservoir in the human microflora. Science. 325(5944):1128–1131. doi:10.1126/science.1176950.
  • Sørensen SJ, Bailey M, Hansen LH, Kroer N, Wuertz S. 2005. Studying plasmid horizontal transfer in situ: a critical review. Nat Rev Microbiol. 3(9):700–710. doi:10.1038/nrmicro1232.
  • Stage TB, Bergmann TK, Kroetz DL. 2018. Clinical pharmacokinetics of paclitaxel monotherapy: an updated literature review. Clin Pharmacokinet. 57(1):7–19. doi:10.1007/s40262-017-0563-z.
  • Stalder T, Top E. 2016. Plasmid transfer in biofilms: a perspective on limitations and opportunities. NPJ Biofilms Microbiomes. 2:16022–16022. doi:10.1038/npjbiofilms.2016.22.
  • Sun J, Chen C, Cui C-Y, Zhang Y, Liu X, Cui Z-H, Ma X-Y, Feng Y, Fang L-X, Lian X-L, et al. 2019. Plasmid-encoded tet(X) genes that confer high-level tigecycline resistance in Escherichia coli. Nat Microbiol. 4(9):1457–1464. doi:10.1038/s41564-019-0496-4.
  • Suzuki S, Kimura M, Agusa T, Rahman HM. 2012. Vanadium accelerates horizontal transfer of tet(M) gene from marine Photobacterium to Escherichia coli. FEMS Microbiol Lett. 336(1):52–56. doi:10.1111/j.1574-6968.2012.02653.x.
  • Tang H, Liu Z, Hu B, Zhu L. 2022. Effects of iron mineral adhesion on bacterial conjugation: interfering the transmission of antibiotic resistance genes through an interfacial process. J Hazard Mater. 435:128889. doi:10.1016/j.jhazmat.2022.128889.
  • Thomas CM, Nielsen KM. 2005. Mechanisms of, and barriers to, horizontal gene transfer between bacteria. Nat Rev Microbiol. 3(9):711–721. doi:10.1038/nrmicro1234.
  • Thomson VJ, Jovanovic OS, Pohlman RF, Chang CH, Figurski DH. 1993. Structure, function, and regulation of the kilB locus of promiscuous plasmid RK2. J Bacteriol. 175(8):2423–2435. doi:10.1128/jb.175.8.2423-2435.1993.
  • Van Bruggen AHC, He MM, Shin K, Mai V, Jeong KC, Finckh MR, Morris JG.Jr 2018. Environmental and health effects of the herbicide glyphosate. Sci Total Environ. 616-617:255–268. doi:10.1016/j.scitotenv.2017.10.309.
  • Vats P, Kaur UJ, Rishi P. 2022. Heavy metal‐induced selection and proliferation of antibiotic resistance: A review. J Appl Microbiol. 132(6):4058–4076. doi:10.1111/jam.15492.
  • Vich Vila A, Collij V, Sanna S, Sinha T, Imhann F, Bourgonje AR, Mujagic Z, Jonkers DMAE, Masclee AAM, Fu J, et al. 2020. Impact of commonly used drugs on the composition and metabolic function of the gut microbiota. Nat Commun. 11(1):362. doi:10.1038/s41467-019-14177-z.
  • Virolle C, Goldlust K, Djermoun S, Bigot S, Lesterlin C. 2020. Plasmid transfer by conjugation in gram-negative bacteria: from the cellular to the community level. Genes (Basel). 11(11):1239. doi:10.3390/genes11111239.
  • Waksman G. 2019. From conjugation to T4S systems in Gram-negative bacteria: a mechanistic biology perspective. EMBO Rep. 20:1–16.
  • Walsh J, Griffin BT, Clarke G, Hyland NP. 2018. Drug-gut microbiota interactions: implications for neuropharmacology. Br J Pharmacol. 175(24):4415–4429. doi:10.1111/bph.14366.
  • Wang C, Feng Y, Liu L, Wei L, Kang M, Zong Z. 2020a. Identification of novel mobile colistin resistance gene mcr-10. Emerg Microbes Infect. 9(1):508–516. doi:10.1080/22221751.2020.1732231.
  • Wang Q, Mao D, Mu Q, Luo Y. 2015. Enhanced horizontal transfer of antibiotic resistance genes in freshwater microcosms induced by an ionic liquid. PLoS One. 10(5):e0126784. doi:10.1371/journal.pone.0126784.
  • Wang Q, Liu L, Hou Z, Wang L, Ma D, Yang G, Guo S, Luo J, Qi L, Luo Y. 2020b. Heavy metal copper accelerates the conjugative transfer of antibiotic resistance genes in freshwater microcosms. Sci Total Environ. 717:137055. doi:10.1016/j.scitotenv.2020.137055.
  • Wang X, Chen Z, Mu Q, Wu X, Zhang J, Mao D, Luo Y, Alvarez PJJ. 2020c. Ionic liquid enriches the antibiotic resistome, especially efflux pump genes, before significantly affecting microbial community structure. Environ Sci Technol. 54(7):4305–4315. doi:10.1021/acs.est.9b04116.
  • Wang Y, Lu J, Mao L, Li J, Yuan Z, Bond PL, Guo J. 2019. Antiepileptic drug carbamazepine promotes horizontal transfer of plasmid-borne multi-antibiotic resistance genes within and across bacterial genera. ISME J. 13(2):509–522. doi:10.1038/s41396-018-0275-x.
  • Wang Y, Lu J, Zhang S, Li J, Mao L, Yuan Z, Bond PL, Guo J. 2021. Non-antibiotic pharmaceuticals promote the transmission of multidrug resistance plasmids through intra- and intergenera conjugation. ISME J. 15(9):2493–2508. doi:10.1038/s41396-021-00945-7.
  • Wang Y, Yu Z, Ding P, Lu J, Klümper U, Murray AK, Gaze WH, Guo J. 2022. Non-antibiotic pharmaceuticals promote conjugative plasmid transfer at a community-wide level. Microbiome. 10(1):124. doi:10.1186/s40168-022-01314-y.
  • Wang Y, Lu J, Engelstädter J, Zhang S, Ding P, Mao L, Yuan Z, Bond PL, Guo J. 2020d. Non-antibiotic pharmaceuticals enhance the transmission of exogenous antibiotic resistance genes through bacterial transformation. ISME J. 14(8):2179–2196. doi:10.1038/s41396-020-0679-2.
  • Wang Y, Yu Z, Ding P, Lu J, Mao L, Ngiam L, Yuan Z, Engelstadter J, Schembri MA, Guo J. 2023. Antidepressants can induce mutation and enhance persistence toward multiple antibiotics. Proc Natl Acad Sci U S A. 120(5):e2208344120. doi:10.1073/pnas.2208344120.
  • Wang Y-F, Qiao M, Zhu D, Zhu Y-G. 2020e. Antibiotic resistance in the collembolan gut microbiome accelerated by the nonantibiotic drug carbamazepine. Environ Sci Technol. 54(17):10754–10762. doi:10.1021/acs.est.0c03075.
  • Weersma RK, Zhernakova A, Fu J. 2020. Interaction between drugs and the gut microbiome. Gut. 69(8):1510–1519. doi:10.1136/gutjnl-2019-320204.
  • Weise K, Winter L, Fischer E, Kneis D, de la Cruz Barron M, Kunze S, Berendonk TU, Jungmann D, Klumper U. 2022. Multiwalled carbon nanotubes promote bacterial conjugative plasmid transfer. Microbiol Spectr. 10(2):e0041022. doi:10.1128/spectrum.00410-22.
  • Weisser J, Wiedemann B. 1985. Elimination of plasmids by new 4-quinolones. Antimicrob Agents Chemother. 28(5):700–702. doi:10.1128/AAC.28.5.700.
  • Winter M, Buckling A, Harms K, Johnsen PJ, Vos M. 2021. Antimicrobial resistance acquisition via natural transformation: context is everything. Curr Opin Microbiol. 64:133–138. doi:10.1016/j.mib.2021.09.009.
  • Xiao X, Zeng F, Li R, Liu Y, Wang Z. 2022. subinhibitory concentration of colistin promotes the conjugation frequencies of mcr-1- and blaNDM-5-positive plasmids. Microbiol Spectr. 10(2):e02160-02121. doi:10.1128/spectrum.02160-21.
  • Xie M, Yang X, Xu Q, Ye L, Chen K, Zheng Z, Dong N, Sun Q, Shu L, Gu D, et al. 2021. Clinical evolution of ST11 carbapenem resistant and hypervirulent Klebsiella pneumoniae. Commun Biol. 4(1):650. doi:10.1038/s42003-021-02148-4.
  • Yang B, Wang Z, Jia Y, Fang D, Li R, Liu Y. 2022. Paclitaxel and its derivative facilitate the transmission of plasmid-mediated antibiotic resistance genes through conjugative transfer. Sci Total Environ. 810:152245. doi:10.1016/j.scitotenv.2021.152245.
  • Yang QE, Agouri SR, Tyrrell JM, Walsh TR. 2018. Heavy metal resistance genes are associated with bla(NDM-1)- and bla(CTX-M-15)-carrying Enterobacteriaceae. Antimicrob Agents Chemother. 62(5):1–7. doi:10.1128/AAC.02642-17.
  • Yaseen DA, Scholz M. 2019. Textile dye wastewater characteristics and constituents of synthetic effluents: a critical review. Int J Environ Sci Technol. 16(2):1193–1226. doi:10.1007/s13762-018-2130-z.
  • Yu Z, Henderson IR, Guo J. 2023. Non-caloric artificial sweeteners modulate conjugative transfer of multi-drug resistance plasmid in the gut microbiota. Gut Microbes. 15(1):2157698. doi:10.1080/19490976.2022.2157698.
  • Yu Z, Wang Y, Henderson IR, Guo J. 2022. Artificial sweeteners stimulate horizontal transfer of extracellular antibiotic resistance genes through natural transformation. ISME J. 16(2):543–554. doi:10.1038/s41396-021-01095-6.
  • Yu Z, Wang Y, Lu J, Bond PL, Guo J. 2021. Nonnutritive sweeteners can promote the dissemination of antibiotic resistance through conjugative gene transfer. ISME J. 15(7):2117–2130. doi:10.1038/s41396-021-00909-x.
  • Zhang H, Liu J, Wang L, Zhai Z. 2021. Glyphosate escalates horizontal transfer of conjugative plasmid harboring antibiotic resistance genes. Bioengineered. 12(1):63–69. doi:10.1080/21655979.2020.1862995.
  • Zhang PY, Xu PP, Xia ZJ, Wang J, Xiong J, Li YZ. 2013. Combined treatment with the antibiotics kanamycin and streptomycin promotes the conjugation of Escherichia coli. FEMS Microbiol Lett. 348(2):149–156. doi:10.1111/1574-6968.12282.
  • Zhang S, Wang Y, Song H, Lu J, Yuan Z, Guo J. 2019. Copper nanoparticles and copper ions promote horizontal transfer of plasmid-mediated multi-antibiotic resistance genes across bacterial genera. Environ Int. 129:478–487. doi:10.1016/j.envint.2019.05.054.
  • Zhang Y, Geissen S-U, Gal C. 2008. Carbamazepine and diclofenac: removal in wastewater treatment plants and occurrence in water bodies. Chemosphere. 73(8):1151–1161. doi:10.1016/j.chemosphere.2008.07.086.
  • Zhang Y, Gu AZ, Cen T, Li X, He M, Li D, Chen J. 2018. Sub-inhibitory concentrations of heavy metals facilitate the horizontal transfer of plasmid-mediated antibiotic resistance genes in water environment. Environ Pollut. 237:74–82. doi:10.1016/j.envpol.2018.01.032.
  • Zheng B, Dong H, Xu H, Lv J, Zhang J, Jiang X, Du Y, Xiao Y, Li L. 2016. Coexistence of MCR-1 and NDM-1 in clinical Escherichia coli isolates. Clin Infect Dis. 63(10):1393–1395. doi:10.1093/cid/ciw553.
  • Zhou Y, Ai W, Cao Y, Guo Y, Wu X, Wang B, Rao L, Xu Y, Zhao H, Wang X, et al. 2021. The Co-occurrence of NDM-5, MCR-1, and FosA3-Encoding Plasmids Contributed to the Generation of Extensively Drug-Resistant Klebsiella pneumoniae. Front Microbiol. 12:811263. doi:10.3389/fmicb.2021.811263.