Probiotics for pancreatic β-cell function: from possible mechanism of action to assessment of effectiveness

References

• Abenavoli L, Falalyeyeva T, Pellicano R, Fagoonee S, Kobyliak N. 2020. Next-generation of strain specific probiotics in diabetes treatment: the case of Prevotella copri. Minerva Endocrinol. 45(4):277–279. doi:10.23736/S0391-1977.20.03376-3.
   PubMed Web of Science ®Google Scholar
• Åberg S, Mann J, Neumann S, Ross AB, Reynolds AN. 2020. Whole-grain processing and glycemic control in type 2 diabetes: a randomized crossover trial. Diabetes Care. 43(8):1717–1723. doi:10.2337/dc20-0263.
   PubMed Web of Science ®Google Scholar
• Akbari V, Hendijani F. 2016. Effects of probiotic supplementation in patients with type 2 diabetes: systematic review and meta-analysis. Nutr Rev. 74(12):774–784. doi:10.1093/nutrit/nuw039.
   PubMed Web of Science ®Google Scholar
• Aludwan M, Kobyliak N, Abenavoli L, Kyriienko D, Fagoonee S, Pellicano R, Komisarenko I. 2020. Vitamin D3 deficiency is associated with more severe insulin resistance and metformin use in patients with type 2 diabetes. Minerva Endocrinol. 45(3):172–180. doi:10.23736/S0391-1977.20.03161-2.
   PubMed Web of Science ®Google Scholar
• Andersson A, Tengblad S, Karlström B, Kamal-Eldin A, Landberg R, Basu S, Åman P, Vessby B. 2007. Whole-grain foods do not affect insulin sensitivity or markers of lipid peroxidation and inflammation in healthy, moderately overweight subjects. J Nutr. 137(6):1401–1407. doi:10.1093/JN/137.6.1401.
   PubMed Web of Science ®Google Scholar
• Andreasen AS, Larsen N, Pedersen-Skovsgaard T, Berg RMG, Møller K, Svendsen KD, Jakobsen M, Pedersen BK. 2010. Effects of Lactobacillus acidophilus NCFM on insulin sensitivity and the systemic inflammatory response in human subjects. Br J Nutr. 104(12):1831–1838. doi:10.1017/S0007114510002874.
   PubMed Web of Science ®Google Scholar
• Anzawa D, Mawatari T, Tanaka Y, Yamamoto M, Genda T, Takahashi S, Nishijima T, Kamasaka H, Suzuki S, Kuriki T. 2019. Effects of synbiotics containing Bifidobacterium animalis subsp. lactis GCL2505 and inulin on intestinal bifidobacteria: a randomized, placebo-controlled, crossover study. Food Sci Nutr. 7(5):1828–1837. doi:10.1002/fsn3.1033.
   PubMed Web of Science ®Google Scholar
• Asemi Z, Zare Z, Shakeri H, Sabihi SS, Esmaillzadeh A. 2013. Effect of multispecies probiotic supplements on metabolic profiles, hs-CRP, and oxidative stress in patients with type 2 diabetes. Ann Nutr Metab. 63(1-2):1–9. doi:10.1159/000349922.
   PubMed Web of Science ®Google Scholar
• Ashrafian F, Shahriary A, Behrouzi A, Moradi HR, Keshavarz Azizi Raftar S, Lari A, Hadifar S, Yaghoubfar R, Ahmadi Badi S, Khatami S, et al. 2019. Akkermansia muciniphila-derived extracellular vesicles as a mucosal delivery vector for amelioration of obesity in mice. Front Microbiol. 10:2155. doi:10.3389/fmicb.2019.02155.
   PubMed Web of Science ®Google Scholar
• Ballan R, Saad SMI. 2021. Characteristics of the gut microbiota and potential effects of probiotic supplements in individuals with type 2 diabetes mellitus. Foods. 10(11):2528. doi:10.3390/FOODS10112528.
   PubMed Web of Science ®Google Scholar
• Baothman OA, Zamzami MA, Taher I, Abubaker J, Abu-Farha M. 2016. The role of Gut microbiota in the development of obesity and diabetes. Lipids Health Dis. 15(1):108. doi:10.1186/s12944-016-0278-4.
   PubMedGoogle Scholar
• Bermudez-Brito M, Plaza-Díaz J, Muñoz-Quezada S, Gómez-Llorente C, Gil A. 2012. Probiotic mechanisms of action. Ann Nutr Metab. 61(2):160–174. doi:10.1159/000342079.
   PubMed Web of Science ®Google Scholar
• Binienda A, Twardowska A, Makaro A, Salaga M. 2020. Dietary carbohydrates and lipids in the pathogenesis of leaky gut syndrome: an overview. Int J Mol Sci. 21(21):8368. doi:10.3390/ijms21218368.
   PubMed Web of Science ®Google Scholar
• Bollyky PL, Bice JB, Sweet IR, Falk BA, Gebe JA, Clark AE, Gersuk VH, Aderem A, Hawn TR, Nepom GT. 2009. The toll-like receptor signaling molecule Myd88 contributes to pancreatic beta-cell homeostasis in response to injury. PLoS One. 4(4):e5063. doi:10.1371/JOURNAL.PONE.0005063.
   PubMed Web of Science ®Google Scholar
• Bordalo Tonucci L, Dos Santos KMO, De Luces Fortes Ferreira CL, Ribeiro SMR, De Oliveira LL, Martino HSD. 2017. Gut microbiota and probiotics: focus on diabetes mellitus. Crit Rev Food Sci Nutr. 57(11):2296–2309. doi:10.1080/10408398.2014.934438.
   PubMed Web of Science ®Google Scholar
• Boutagy NE, McMillan RP, Frisard MI, Hulver MW. 2016. Metabolic endotoxemia with obesity: is it real and is it relevant? Biochimie. 124:11–20. doi:10.1016/j.biochi.2015.06.020.
   PubMed Web of Science ®Google Scholar
• Buenaventura T, Kanda N, Douzenis PC, Jones B, Bloom SR, Chabosseau P, Corrêa IR, Bosco D, Piemonti L, Marchetti P, et al. 2018. A targeted RNAi screen identifies endocytic trafficking factors that control GLP-1 receptor signaling in pancreatic β-cells. Diabetes. 67(3):385–399. doi:10.2337/db17-0639.
   PubMed Web of Science ®Google Scholar
• Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, Neyrinck AM, Fava F, Tuohy KM, Chabo C, et al. 2007. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 56(7):1761–1772. doi:10.2337/db06-1491.
   PubMed Web of Science ®Google Scholar
• Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM, Burcelin R. 2008. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes. 57(6):1470–1481. doi:10.2337/db07-1403.
   PubMed Web of Science ®Google Scholar
• Cani PD, de Vos WM. 2017. Next-generation beneficial microbes: the case of Akkermansia muciniphila. Front Microbiol. 8(SEP):1765. doi:10.3389/fmicb.2017.01765.
   PubMedGoogle Scholar
• Cani PD, Neyrinck AM, Maton N, Delzenne NM. 2005. Oligofructose promotes satiety in rats fed a high-fat diet: involvement of glucagon-like Peptide-1. Obes Res. 13(6):1000–1007. doi:10.1038/OBY.2005.117.
   PubMedGoogle Scholar
• Chang CJ, Lin TL, Tsai YL, Wu TR, Lai WF, Lu CC, Lai HC. 2019. Next generation probiotics in disease amelioration. J Food Drug Anal. 27(3):615–622. doi:10.1016/j.jfda.2018.12.011.
   PubMed Web of Science ®Google Scholar
• Chen J, Pi X, Liu W, Ding Q, Wang X, Jia W, Zhu L. 2021. Age-related changes of microbiota in midlife associated with reduced saccharolytic potential: an in vitro study. BMC Microbiol. 21(1):47. doi:10.1186/s12866-021-02103-7.
   PubMed Web of Science ®Google Scholar
• Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L. 2018. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 9(6):7204–7218. doi:10.18632/oncotarget.23208.
   PubMedGoogle Scholar
• Chen P, Zhang Q, Dang H, Liu X, Tian F, Zhao J, Chen Y, Zhang H, Chen W. 2014. Oral administration of Lactobacillus rhamnosus CCFM0528 improves glucose tolerance and cytokine secretion in high-fat-fed, streptozotocin-induced type 2 diabetic mice. J Funct Foods. 10:318–326. doi:10.1016/j.jff.2014.06.014.
   Web of Science ®Google Scholar
• Cheng FS, Pan D, Chang B, Jiang M, Sang LX. 2020. Probiotic mixture VSL#3: an overview of basic and clinical studies in chronic diseases. World J Clin Cases. 8(8):1361–1384. doi:10.12998/WJCC.V8.I8.1361.
   PubMed Web of Science ®Google Scholar
• Christensen AA, Gannon M. 2019. The beta cell in type 2 diabetes. Curr Diab Rep. 19(9):81. doi:10.1007/s11892-019-1196-4.
   PubMed Web of Science ®Google Scholar
• Chung WSF, Walker AW, Louis P, Parkhill J, Vermeiren J, Bosscher D, Duncan SH, Flint HJ. 2016. Modulation of the human gut microbiota by dietary fibres occurs at the species level. BMC Biol. 14(1):3. doi:10.1186/s12915-015-0224-3.
   PubMedGoogle Scholar
• D’Addio F, Fiorina P. 2016. Type 1 diabetes and dysfunctional intestinal homeostasis. Trends Endocrinol Metab. 27(7):493–503. doi:10.1016/J.TEM.2016.04.005.
   PubMed Web of Science ®Google Scholar
• Deguine J, Barton GM. 2014. MyD88: a central player in innate immune signaling. F1000Prime Rep. 6:97. doi:10.12703/P6-97.
   PubMedGoogle Scholar
• Depommier C, Everard A, Druart C, Plovier H, Van Hul M, Vieira-Silva S, Falony G, Raes J, Maiter D, Delzenne NM, et al. 2019. Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Nat Med. 25(7):1096–1103. doi:10.1038/s41591-019-0495-2.
   PubMed Web of Science ®Google Scholar
• Duan F, Curtis KL, March JC. 2008. Secretion of insulinotropic proteins by commensal bacteria: rewiring the gut to treat diabetes. Appl Environ Microbiol. 74(23):7437–7438. doi:10.1128/AEM.01019-08.
   PubMed Web of Science ®Google Scholar
• Duan FF, Liu JH, March JC. 2015. Engineered commensal bacteria reprogram intestinal cells into glucose-responsive insulin-secreting cells for the treatment of diabetes. Diabetes. 64(5):1794–1803. doi:10.2337/DB14-0635/-/DC1.
   PubMed Web of Science ®Google Scholar
• Ebrahimi ZS, Nasli-Esfahani E, Nadjarzade A, Mozaffari-Khosravi H. 2017. Effect of symbiotic supplementation on glycemic control, lipid profiles and microalbuminuria in patients with non-obese type 2 diabetes: a randomized, double-blind, clinical trial. J Diabetes Metab Disord. 16(1):23. doi:10.1186/s40200-017-0304-8.
   PubMedGoogle Scholar
• Eguchi K, Nagai R. 2017. Islet inflammation in type 2 diabetes and physiology. J Clin Invest. 127(1):14–23. doi:10.1172/JCI88877.
   PubMed Web of Science ®Google Scholar
• Eguchi N, Vaziri ND, Dafoe DC, Ichii H. 2021. The Role of Oxidative Stress in Pancreatic β Cell Dysfunction in Diabetes. Int J Mol Sci. 22(4):1509. doi:10.3390/IJMS22041509.
   PubMed Web of Science ®Google Scholar
• Eizirik DL, Pasquali L, Cnop M. 2020. Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure. Nat Rev Endocrinol. 16(7):349–362. doi:10.1038/s41574-020-0355-7.
   PubMed Web of Science ®Google Scholar
• Ejtahed HS, Mohtadi-Nia J, Homayouni-Rad A, Niafar M, Asghari-Jafarabadi M, Mofid, V. 2012. Probiotic yogurt improves antioxidant status in type 2 diabetic patients. Nutrition. 28(5):539–543. doi:10.1016/j.nut.2011.08.013.
   Google Scholar
• Eslami M, Bahar A, Hemati M, Rasouli Nejad Z, Mehranfar F, Karami S, Kobyliak NM, Yousefi B. 2021. Dietary pattern, colonic microbiota and immunometabolism interaction: new frontiers for diabetes mellitus and related disorders. Diabet Med. 38(2):e1441. doi:10.1111/dme.14415.
   Web of Science ®Google Scholar
• Eslami M, Sadrifar S, Karbalaei M, Keikha M, Kobyliak NM, Yousefi B. 2020. Importance of the microbiota inhibitory mechanism on the warburg effect in colorectal cancer cells. J Gastrointest Cancer. 51(3):738–747. doi:10.1007/s12029-019-00329-3.
   PubMed Web of Science ®Google Scholar
• Everard A, Belzer C, Geurts L, Ouwerkerk JP, Druart C, Bindels LB, Guiot Y, Derrien M, Muccioli GG, Delzenne NM, et al. 2013. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci U S A. 110(22):9066–9071. doi:10.1073/pnas.1219451110.
   PubMed Web of Science ®Google Scholar
• Everard A, Matamoros S, Geurts L, Delzenne NM, Cani PD. 2014. Saccharomyces boulardii administration changes gut microbiota and reduces hepatic steatosis, low-grade inflammation, and fat mass in obese and type 2 diabetic db/db mice. MBio. 5(3):e01011–e01014. doi:10.1128/mBio.01011-14.
   PubMed Web of Science ®Google Scholar
• Evseev A. 2019. Medical nutrition therapy in type 2 diabetes mellitus. BSP. 5(10):77–83. doi:10.33619/2414-2948/47/11.
   Google Scholar
• Fan Y, Pedersen O. 2021. Gut microbiota in human metabolic health and disease. Nat Rev Microbiol. 19(1):55–71. doi:10.1038/s41579-020-0433-9.
   PubMed Web of Science ®Google Scholar
• FAO/WHO (2020) Probiotics in food health and nutritional properties and guidelines for evaluation FAO food and nutrition paper.
   Google Scholar
• Firouzi S, Majid HA, Ismail A, Kamaruddin NA, Barakatun-Nisak MY. 2017. Effect of multi-strain probiotics (multi-strain microbial cell preparation) on glycemic control and other diabetes-related outcomes in people with type 2 diabetes: a randomized controlled trial. Eur J Nutr. 56(4):1535–1550. doi:10.1007/s00394-016-1199-8.
   PubMed Web of Science ®Google Scholar
• Ganesan K, Chung SK, Vanamala J, Xu B. 2018. Causal relationship between diet-induced gut microbiota changes and diabetes: a novel strategy to transplant Faecalibacterium prausnitzii in preventing diabetes. Int J Mol Sci. 19(12):3720. doi:10.3390/ijms19123720.
   PubMed Web of Science ®Google Scholar
• Gao X, Lin SH, Ren F, Li JT, Chen JJ, Yao CB, Yang HB, Jiang SX, Yan GQ, Wang D, et al. 2016. Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 7(1):11960. doi:10.1038/ncomms11960.
   PubMedGoogle Scholar
• García-García FJ, Monistrol-Mula A, Cardellach F, Garrabou G. 2020. Nutrition, bioenergetics, and metabolic syndrome. Nutrients. 12(9):2785. doi:10.3390/nu12092785.
   PubMed Web of Science ®Google Scholar
• Geerlings S, Kostopoulos I, de Vos W, Belzer C. 2018. Akkermansia muciniphila in the Human Gastrointestinal Tract: when, Where, and How? Microorganisms. 6(3):75. doi:10.3390/microorganisms6030075.
   PubMed Web of Science ®Google Scholar
• González Hernández MA, Canfora EE, Jocken JWE, Blaak EE. 2019. The short-chain fatty acid acetate in body weight control and insulin sensitivity. Nutrients. 11(8):1943. doi:10.3390/nu11081943.
   PubMed Web of Science ®Google Scholar
• Gu Y, Li H, Bao X, Zhang Q, Liu L, Meng G, Wu H, Du H, Shi H, Xia Y, et al. 2017. The relationship between thyroid function and the prevalence of type 2 diabetes mellitus in euthyroid subjects. J Clin Endocrinol Metab. 102(2):434–442. doi:10.1210/jc.2016-2965.
   PubMed Web of Science ®Google Scholar
• Guariguata L, Whiting DR, Hambleton I, Beagley J, Linnenkamp U, Shaw JE. 2014. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract. 103(2):137–149. doi:10.1016/j.diabres.2013.11.002.
   PubMed Web of Science ®Google Scholar
• Guja C, Frías JP, Somogyi A, Jabbour S, Wang H, Hardy E, Rosenstock J. 2018. Effect of exenatide QW or placebo, both added to titrated insulin glargine, in uncontrolled type 2 diabetes: the DURATION-7 randomized study. Diabetes Obes Metab. 20(7):1602–1614. doi:10.1111/dom.13266.
   PubMed Web of Science ®Google Scholar
• Guo X, Zhang J, Wu F, Zhang M, Yi M, Peng Y. 2016. Different subtype strains of Akkermansia muciniphila abundantly colonize in southern China. J Appl Microbiol. 120(2):452–459. doi:10.1111/jam.13022.
   PubMed Web of Science ®Google Scholar
• Gurung M, Li Z, You H, Rodrigues R, Jump DB, Morgun A, Shulzhenko N. 2020. Role of gut microbiota in type 2 diabetes pathophysiology. EBioMedicine. 51:102590. doi:10.1016/j.ebiom.2019.11.051.
   PubMed Web of Science ®Google Scholar
• Hampe CS, Roth CL. 2017. Probiotic strains and mechanistic insights for the treatment of type 2 diabetes. Endocrine. 58(2):207–227. doi:10.1007/S12020-017-1433-Z.
   PubMed Web of Science ®Google Scholar
• Harsch I, Konturek P. 2018. The role of gut microbiota in obesity and type 2 and type 1 diabetes mellitus: new insights into “old” diseases. Medical Sciences. 6(2):32. doi:10.3390/medsci6020032.
   Google Scholar
• Hartstra AV, Bouter KEC, Bäckhed F, Nieuwdorp M. 2015. Insights into the role of the microbiome in obesity and type 2 diabetes. Diabetes Care. 38(1):159–165. doi:10.2337/dc14-0769.
   PubMed Web of Science ®Google Scholar
• Hasain Z, Mokhtar NM, Kamaruddin NA, Mohamed Ismail NA, Razalli NH, Gnanou JV, Raja Ali RA. 2020. Gut microbiota and gestational diabetes mellitus: a review of host-gut microbiota interactions and their therapeutic potential. Front Cell Infect Microbiol. 10:188. doi:10.3389/fcimb.2020.00188.
   PubMed Web of Science ®Google Scholar
• Hasnain SZ, Borg DJ, Harcourt BE, Tong H, Sheng YH, Ng CP, Das I, Wang R, Chen ACH, Loudovaris T, et al. 2014. Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress. Nat Med. 20(12):1417–1426. doi:10.1038/NM.3705.
   PubMed Web of Science ®Google Scholar
• He J, Zhang P, Shen L, Niu L, Tan Y, Chen L, Zhao Y, Bai L, Hao X, Li X, et al. 2020. Short-chain fatty acids and their association with signalling pathways in inflammation, glucose and lipid metabolism. Int J Mol Sci. 21(17):6356. doi:10.3390/ijms21176356.
   PubMed Web of Science ®Google Scholar
• Hegazy SK, El-Bedewy MM. 2010. Effect of probiotics on pro-inflammatory cytokines and NF-kappaB activation in ulcerative colitis. World J Gastroenterol. 16(33):4145–4151. doi:10.3748/WJG.V16.I33.4145.
   PubMed Web of Science ®Google Scholar
• Horiuchi H, Kamikado K, Aoki R, Suganuma N, Nishijima T, Nakatani A, Kimura I. 2020. Bifidobacterium animalis subsp. lactis GCL2505 modulates host energy metabolism via the short-chain fatty acid receptor GPR43. Sci Rep. 10(1):4158. doi:10.1038/s41598-020-60984-6.
   PubMed Web of Science ®Google Scholar
• Hsieh MC, Tsai WH, Jheng YP, Su SL, Wang SY, Lin CC, Chen YH, Chang WW. 2020. The beneficial effects of Lactobacillus reuteri ADR-1 or ADR-3 consumption on type 2 diabetes mellitus: a randomized, double-blinded, placebo-controlled trial. Sci Rep. 10(1):3872. doi:10.1038/s41598-018-35014-1.
   PubMed Web of Science ®Google Scholar
• Hsieh PS, Ho HH, Tsao SP, Hsieh SH, Lin WY, Chen JF, Kuo YW, Tsai SY, Huang HY. 2021. Multi-strain probiotic supplement attenuates streptozotocin-induced type-2 diabetes by reducing inflammation and β-cell death in rats. PLoS One. 16(6):e0251646. doi:10.1371/JOURNAL.PONE.0251646.
   PubMed Web of Science ®Google Scholar
• Huang D, Gao J, Li C, Nong C, Huang W, Zheng X, Li S, Peng Y. 2021. A potential probiotic bacterium for antipsychotic-induced metabolic syndrome: mechanisms underpinning how Akkermansia muciniphila subtype improves olanzapine-induced glucose homeostasis in mice. Psychopharmacology. 238(9):2543–2553. doi:10.1007/S00213-021-05878-9.
   PubMed Web of Science ®Google Scholar
• Huang Y-Y, Qin X-K, Dai Y-Y, Huang L, Huang G-R, Qin Y-C, Wei X, Huang Y-Q. 2022. Preparation and hypoglycemic effects of chromium- and zinc-rich Acetobacter aceti. World J Diabetes. 13(6):442–453. doi:10.4239/WJD.V13.I6.442.
   PubMed Web of Science ®Google Scholar
• Hwang M, Go Y, Park JH, Shin SK, Song SE, Oh BC, Im SS, Hwang I, Jeon YH, Lee IK, et al. 2017. Epac2a-null mice exhibit obesity-prone nature more susceptible to leptin resistance. Int J Obes (Lond). 41(2):279–288. doi:10.1038/ijo.2016.208.
   PubMed Web of Science ®Google Scholar
• Jetton TL, Lausier J, LaRock K, Trotman WE, Larmie B, Habibovic A, Peshavaria M, Leahy JL. 2005. Mechanisms of compensatory beta-cell growth in insulin-resistant rats: roles of Akt kinase. Diabetes. 54(8):2294–2304. doi:10.2337/DIABETES.54.8.2294.
   PubMed Web of Science ®Google Scholar
• Ji Y, Sun S, Shrestha N, Darragh LB, Shirakawa J, Xing Y, He Y, Carboneau BA, Kim H, An D, et al. 2019. Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity. Nat Immunol. 20(6):677–686. doi:10.1038/s41590-019-0396-z.
   PubMed Web of Science ®Google Scholar
• Jialal I, Kaur H, Devaraj S. 2014. Toll-like receptor status in obesity and metabolic syndrome: a translational perspective. J Clin Endocrinol Metab. 99(1):39–48. doi:10.1210/jc.2013-3092.
   PubMed Web of Science ®Google Scholar
• Jiandong L, Yang Y, Peng J, Xiang M, Wang D, Xiong G, Li S. 2019. Trichosanthes kirilowii lectin ameliorates streptozocin-induced kidney injury via modulation of the balance between M1/M2 phenotype macrophage. Biomed Pharmacother. 109:93–102. doi:10.1016/J.BIOPHA.2018.10.060.
   PubMed Web of Science ®Google Scholar
• Karl JP, Margolis LM, Madslien EH, Murphy NE, Castellani JW, Gundersen Y, Hoke AV, Levangie MW, Kumar R, Chakraborty N, et al. 2017. Changes in intestinal microbiota composition and metabolism coincide with increased intestinal permeability in young adults under prolonged physiological stress. Am J Physiol Gastrointest Liver Physiol. 312(6):G559–G571. doi:10.1152/AJPGI.00066.2017.
   PubMed Web of Science ®Google Scholar
• Kasińska MA, Drzewoski J. 2015. Effectiveness of probiotics in type 2 diabetes: a meta-analysis. Pol Arch Med Wewn. 125(11):803–813. doi:10.20452/pamw.3156.
   PubMed Web of Science ®Google Scholar
• Kesika P, Sivamaruthi BS, Chaiyasut C. 2019. Do Probiotics Improve the Health Status of Individuals with Diabetes Mellitus? A Review on Outcomes of Clinical Trials. In Biomed Res Int. 2019:1531567–1531511. Hindawi Limited. doi:10.1155/2019/1531567.
   PubMed Web of Science ®Google Scholar
• Kijmanawat A, Panburana P, Reutrakul S, Tangshewinsirikul C. 2019. Effects of probiotic supplements on insulin resistance in gestational diabetes mellitus: a double-blind randomized controlled trial. J Diabetes Investig. 10(1):163–170. doi:10.1111/jdi.12863.
   PubMed Web of Science ®Google Scholar
• Kim CH. 2018. Immune regulation by microbiome metabolites. Immunology. 154(2):220–229. doi:10.1111/IMM.12930.
   PubMed Web of Science ®Google Scholar
• Knip M, Siljander H. 2016. The role of the intestinal microbiota in type 1 diabetes mellitus. Nat Rev Endocrinol. 12(3):154–167. doi:10.1038/nrendo.2015.218.
   PubMed Web of Science ®Google Scholar
• Kobyliak N, Abenavoli L, Falalyeyeva T, Kovalchuk O, Kyriienko D, Komisarenko I. 2021. Metabolic benefits of probiotic combination with absorbent smectite in type 2 diabetes patients a randomised controlled Trial. Rev Recent Clin Trials. 16(1):109–119. doi:10.2174/1574887115666200709141131.
   PubMed Web of Science ®Google Scholar
• Kobyliak N, Falalyeyeva T, Kyriachenko Y, Tseyslyer Y, Kovalchuk O, Hadiliia O, Eslami M, Yousefi B, Abenavoli L, Fagoonee S, et al. 2022. Akkermansia muciniphila as a novel powerful bacterial player in the treatment of metabolic disorders. Minerva Endocrinol (Torino). 47(2):242–252. doi:10.23736/S2724-6507.22.03752-6.
   PubMedGoogle Scholar
• Kobyliak N, Falalyeyeva T, Mykhalchyshyn G, Kyriienko D, Komissarenko I. 2018. Effect of alive probiotic on insulin resistance in type 2 diabetes patients: randomized clinical trial. Diabetes Metab Syndr. 12(5):617–624. doi:10.1016/j.dsx.2018.04.015.
   PubMed Web of Science ®Google Scholar
• Kobyliak N, Falalyeyeva T, Mykhalchyshyn G, Molochek N, Savchuk O, Kyriienko D, Komisarenko I. 2020. Probiotic and omega-3 polyunsaturated fatty acids supplementation reduces insulin resistance, improves glycemia and obesity parameters in individuals with type 2 diabetes: a randomised controlled trial. Obesity Medicine. 19:100248. doi:10.1016/j.obmed.2020.100248.
   Google Scholar
• Kobyliak N, Virchenko O, Falalyeyeva T. 2015. Pathophysiological role of host microbiota in the development of obesity. Nutr J. 15(1):43. doi:10.1186/s12937-016-0166-9.
   Google Scholar
• Koh A, De Vadder F, Kovatcheva-Datchary P, Bäckhed F. 2016. From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell. 165(6):1332–1345. doi:10.1016/j.cell.2016.05.041.
   PubMed Web of Science ®Google Scholar
• Korotkyi O, Vovk A, Galenova T, Vovk T, Dvorschenko K, Luzza F, Abenavoli L, Kobyliak N, Falalyeyeva T, Ostapchenko L. 2019. Effect of probiotic on serum cytokines and matrix metalloproteinases profiles during monoiodoacetate-induced osteoarthritis in rats. Minerva Biotecnol. 31(2):68–73. doi:10.23736/S1120-4826.19.02548-5.
   Web of Science ®Google Scholar
• Kreznar JH, Keller MP, Traeger LL, Rabaglia ME, Schueler KL, Stapleton DS, Zhao W, Vivas EI, Yandell BS, Broman AT, et al. 2017. Host Genotype and Gut Microbiome Modulate Insulin Secretion and Diet-Induced Metabolic Phenotypes. Cell Rep. 18(7):1739–1750. doi:10.1016/j.celrep.2017.01.062.
   PubMed Web of Science ®Google Scholar
• Kullisaar T, Zilmer M, Mikelsaar M, Vihalemm T, Annuk H, Kairane C, Kilk A. 2002. Two antioxidative lactobacilli strains as promising probiotics. Int J Food Microbiol. 72(3):215–224. doi:10.1016/S0168-1605(01)00674-2.
   PubMed Web of Science ®Google Scholar
• Kumar H, Kawai T, Akira S. 2011. Pathogen recognition by the innate immune system. Int Rev Immunol. 30(1):16–34. doi:10.3109/08830185.2010.529976.
   PubMed Web of Science ®Google Scholar
• Li AQ, Zhao L, Zhou TF, Zhang MQ, Qin XM. 2015. Exendin-4 promotes endothelial barrier enhancement via PKA- and Epac1-dependent Rac1 activation. Am J Physiol Cell Physiol. 308(2):C164–C175. doi:10.1152/ajpcell.00249.2014.
   PubMed Web of Science ®Google Scholar
• Li BY, Xu XY, Gan RY, Sun QC, Meng JM, Shang A, Mao QQ, Li HB. 2019. Targeting gut microbiota for the prevention and management of diabetes mellitus by dietary natural products. Foods. 8(10):440. doi:10.3390/foods8100440.
   PubMed Web of Science ®Google Scholar
• Li C, Li X, Han H, Cui H, Peng M, Wang G, Wang Z. 2016. Effect of probiotics on metabolic profiles in type 2 diabetes mellitus A meta-analysis of randomized, controlled trials. Medicine. 95(26):e4088. doi:10.1097/MD.0000000000004088.
   PubMed Web of Science ®Google Scholar
• Li X, Atkinson MA. 2015. The role for gut permeability in the pathogenesis of type 1 diabetes - a solid or leaky concept? Pediatr Diabetes. 16(7):485–492. doi:10.1111/pedi.12305.
   PubMed Web of Science ®Google Scholar
• Li X, Wang N, Yin B, Fang D, Jiang T, Fang S, Zhao J, Zhang H, Wang G, Chen W. 2016. Effects of Lactobacillus plantarum CCFM0236 on hyperglycaemia and insulin resistance in high-fat and streptozotocin-induced type 2 diabetic mice. J Appl Microbiol. 121(6):1727–1736. doi:10.1111/JAM.13276.
   PubMed Web of Science ®Google Scholar
• Liu Q, Liu Y, Li F, Gu Z, Liu M, Shao T, Zhang L, Zhou G, Pan C, He L, et al. 2020. Probiotic culture supernatant improves metabolic function through FGF21-adiponectin pathway in mice. J Nutr Biochem. 75:108256. doi:10.1016/J.JNUTBIO.2019.108256.
   PubMed Web of Science ®Google Scholar
• Lorenzo-Pisarello MJ, Gultemirian ML, Nieto-Peñalver C, Perez Chaia A. 2010. Propionibacterium acidipropionici CRL1198 influences the production of acids and the growth of bacterial genera stimulated by inulin in a murine model of cecal slurries. Anaerobe. 16(4):345–354. doi:10.1016/J.ANAEROBE.2010.04.006.
   PubMed Web of Science ®Google Scholar
• Macchione IG, Lopetuso LR, Ianiro G, Napol M, Gibiino G, Rizzatt G, Petito V, Gasbarrini A, Scaldaferri F. 2019. Akkermansia muciniphila: key player in metabolic and gastrointestinal disorders. Eur Rev Med Pharmacol Sci. 23(18):8075–8083. doi:10.26355/eurrev_201909_19024.
   PubMed Web of Science ®Google Scholar
• Martens EC, Chiang HC, Gordon JI. 2008. Mucosal glycan foraging enhances fitness and transmission of a saccharolytic human gut bacterial symbiont. Cell Host Microbe. 4(5):447–457. doi:10.1016/J.CHOM.2008.09.007.
   PubMed Web of Science ®Google Scholar
• Martin AM, Sun EW, Rogers GB, Keating DJ. 2019. The influence of the gut microbiome on host metabolism through the regulation of gut hormone release. Front Physiol. 10(MAR):428. doi:10.3389/FPHYS.2019.00428/BIBTEX.
   PubMedGoogle Scholar
• Martínez I, Lattimer JM, Hubach KL, Case JA, Yang J, Weber CG, Louk JA, Rose DJ, Kyureghian G, Peterson DA, et al. 2013. Gut microbiome composition is linked to whole grain-induced immunological improvements. Isme J. 7(2):269–280. doi:10.1038/ISMEJ.2012.104.
   PubMed Web of Science ®Google Scholar
• Mayer-Davis EJ, Kahkoska AR, Jefferies C, Dabelea D, Balde N, Gong CX, Aschner P, Craig ME. 2018. ISPAD Clinical Practice Consensus Guidelines 2018: definition, epidemiology, and classification of diabetes in children and adolescents. Pediatr Diabetes. 19(Suppl 27):7–19. doi:10.1111/pedi.12773.
   PubMed Web of Science ®Google Scholar
• Mazloom Z, Yousefinejad A, Dabbaghmanesh MH. 2013. Effect of probiotics on lipid profile, glycemic control, insulin action, oxidative stress, and inflammatory markers in patients with type 2 diabetes: A clinical trial. Iran J Med Sci. 38(1):38–43.
   Google Scholar
• Mejía-León ME, Calderón de la Barca AM. 2015. Diet, microbiota and immune system in type 1 diabetes development and evolution. Nutrients. 7(11):9171–9184. doi:10.3390/nu7115461.
   PubMed Web of Science ®Google Scholar
• Messer JS, Chang EB. 2018. Microbial physiology of the digestive tract and its role in inflammatory bowel diseases. Physiol Gastrointestinal Tract. 1:795–810. doi:10.1016/B978-0-12-809954-4.00036-0.
   Google Scholar
• Mikkelsen KH, Knop FK, Frost M, Hallas J, Pottegard A. 2015. Use of antibiotics and risk of type 2 diabetes: a population-based case-control study. J Clin Endocrinol Metab. 100(10):3633–3640. doi:10.1210/JC.2015-2696/SUPPL_FILE/JC-15-2696.PDF.
   PubMed Web of Science ®Google Scholar
• Mobini R, Tremaroli V, Ståhlman M, Karlsson F, Levin M, Ljungberg M, Sohlin M, Bertéus Forslund H, Perkins R, Bäckhed F, et al. 2017. Metabolic effects of Lactobacillus reuteri DSM 17938 in people with type 2 diabetes: a randomized controlled trial. Diabetes Obes Metab. 19(4):579–589. doi:10.1111/dom.12861.
   PubMed Web of Science ®Google Scholar
• Modasia A, Parker A, Jones E, Stentz R, Brion A, Goldson A, Defernez M, Wileman T, Ashley Blackshaw L, Carding SR. 2020. Regulation of enteroendocrine cell networks by the major human gut symbiont bacteroides thetaiotaomicron. Front Microbiol. 11:575595. doi:10.3389/fmicb.2020.575595.
   PubMed Web of Science ®Google Scholar
• Mykhalchyshyn G, Kobyliak N, Bodnar P. 2015. Diagnostic accuracy of acyl-ghrelin and it association with non-alcoholic fatty liver disease in type 2 diabetic patients. J Diabetes Metab Disord. 14(1):44. doi:10.1186/s40200-015-0170-1.
   PubMedGoogle Scholar
• Napolitano M, Covasa M. 2020. Microbiota Transplant in the Treatment of Obesity and Diabetes: current and Future Perspectives. Front Microbiol. 11:590370. doi:10.3389/fmicb.2020.590370.
   PubMed Web of Science ®Google Scholar
• Natividad JM, Agus A, Planchais J, Lamas B, Jarry AC, Martin R, Michel ML, Chong-Nguyen C, Roussel R, Straube M, et al. 2018. Impaired aryl hydrocarbon receptor ligand production by the gut microbiota is a key factor in metabolic syndrome. Cell Metab. 28(5):737–749.e4. doi:10.1016/j.cmet.2018.07.001.
   PubMed Web of Science ®Google Scholar
• Nederstigt C, Corssmit EPM, De Koning EJP, Dekkers OM. 2016. Incidence and prevalence of thyroid dysfunction in type 1 diabetes. J Diabetes Complications. 30(3):420–425. doi:10.1016/j.jdiacomp.2015.12.027.
   PubMed Web of Science ®Google Scholar
• Niibo M, Shirouchi B, Umegatani M, Morita Y, Ogawa A, Sakai F, Kadooka Y, Sato M. 2019. Probiotic Lactobacillus gasseri SBT2055 improves insulin secretion in a diabetic rat model. J Dairy Sci. 102(2):997–1006. doi:10.3168/JDS.2018-15203.
   PubMed Web of Science ®Google Scholar
• Okubo H, Nakatsu Y, Kushiyama A, Yamamotoya T, Matsunaga Y, Inoue M, Fujishiro M, Sakoda H, Ohno H, Yoneda M, et al. 2018. Gut microbiota as a therapeutic target for metabolic disorders. Curr Med Chem. 25(9):984–1001. doi:10.2174/0929867324666171009121702.
   PubMed Web of Science ®Google Scholar
• Olefsky JM, Glass CK. 2010. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol. 72(1):219–246. doi:10.1146/ANNUREV-PHYSIOL-021909-135846.
   PubMed Web of Science ®Google Scholar
• Oliver-Krasinski JM, Kasner MT, Yang J, Crutchlow MF, Rustgi AK, Kaestner KH, Stoffers DA. 2009. The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice. J Clin Invest. 119(7):1888–1898. doi:10.1172/JCI37028.
   PubMed Web of Science ®Google Scholar
• Park KY, Kim B, Hyun CK. 2015. Lactobacillus rhamnosus GG improves glucose tolerance through alleviating ER stress and suppressing macrophage activation in db/db mice. J Clin Biochem Nutr. 56(3):240–246. doi:10.3164/jcbn.14-116.
   PubMed Web of Science ®Google Scholar
• Park S, Bae JH. 2015. Probiotics for weight loss: a systematic review and meta-analysis. Nutr Res. 35(7):566–575. doi:10.1016/j.nutres.2015.05.008.
   PubMed Web of Science ®Google Scholar
• Pedersen HK, Gudmundsdottir V, Nielsen HB, Hyotylainen T, Nielsen T, Jensen BAH, Forslund K, Hildebrand F, Prifti E, Falony G, et al. 2016. Human gut microbes impact host serum metabolome and insulin sensitivity. Nature. 535(7612):376–381. doi:10.1038/nature18646.
   PubMed Web of Science ®Google Scholar
• Peran L, Camuesco D, Comalada M, Nieto A, Concha A, Adrio JL, Olivares M, Xaus J, Zarzuelo A, Galvez J. 2006. Lactobacillus fermentum, a probiotic capable to release glutathione, prevents colonic inflammation in the TNBS model of rat colitis. Int J Colorectal Dis. 21(8):737–746. doi:10.1007/S00384-005-0773-Y.
   PubMed Web of Science ®Google Scholar
• Perraudeau F, McMurdie P, Bullard J, Cheng A, Cutcliffe C, Deo A, Eid J, Gines J, Iyer M, Justice N, et al. 2020. Improvements to postprandial glucose control in subjects with type 2 diabetes: a multicenter, double blind, randomized placebo-controlled trial of a novel probiotic formulation. BMJ Open Diab Res Care. 8(1):e001319. doi:10.1136/bmjdrc-2020-001319.
   PubMed Web of Science ®Google Scholar
• Plovier H, Everard A, Druart C, Depommier C, Van Hul M, Geurts L, Chilloux J, Ottman N, Duparc T, Lichtenstein L, et al. 2017. A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice. Nat Med. 23(1):107–113. doi:10.1038/nm.4236.
   PubMed Web of Science ®Google Scholar
• Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM. 2001. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA. 286(3):327–334. doi:10.1001/JAMA.286.3.327.
   PubMed Web of Science ®Google Scholar
• Prause M, Pedersen SS, Tsonkova V, Qiao M, Billestrup N. 2021. Butyrate protects pancreatic beta cells from cytokine-induced dysfunction. Int J Mol Sci. 22(19):10427. doi:10.3390/IJMS221910427/S1.
   PubMed Web of Science ®Google Scholar
• Priyadarshini M, Villa SR, Fuller M, Wicksteed B, Mackay CR, Alquier T, Poitout V, Mancebo H, Mirmira RG, Gilchrist A, et al. 2015. An acetate-specific GPCR, FFAR2, regulates insulin secretion. Mol Endocrinol. 29(7):1055–1066. doi:10.1210/me.2015-1007.
   PubMed Web of Science ®Google Scholar
• Rad AH, Abbasalizadeh S, Vazifekhah S, Abbasalizadeh F, Hassanalilou T, Bastani P, Ejtahed H-S, Soroush A-R, Javadi M, Mortazavian AM, et al. 2017. The future of diabetes management by healthy probiotic microorganisms. Curr Diabetes Rev. 13(6):582–589. doi:10.2174/1573399812666161014112515.
   PubMed Web of Science ®Google Scholar
• Rajendran VM, Schulzke JD, Seidler UE. 2018. Ion channels of the gastrointestinal epithelial cells. In: Physiology of the gastrointestinal tract, 6th ed., Vol. 2. United States: Elsevier. doi:10.1016/B978-0-12-809954-4.00058-X.
   Google Scholar
• Rendra E, Riabov V, Mossel DM, Sevastyanova T, Harmsen MC, Kzhyshkowska J. 2019. Reactive oxygen species (ROS) in macrophage activation and function in diabetes. Immunobiology. 224(2):242–253. doi:10.1016/J.IMBIO.2018.11.010.
   PubMed Web of Science ®Google Scholar
• Ríos-Covián D, Ruas-Madiedo P, Margolles A, Gueimonde M, De los Reyes-Gavilán CG, Salazar N. 2016. Intestinal short chain fatty acids and their link with diet and human health. Front Microbiol. 7(FEB):185. doi:10.3389/fmicb.2016.00185.
   PubMedGoogle Scholar
• Roager HM, Vogt JK, Kristensen M, Hansen LBS, Ibrügger S, Mærkedahl RB, Bahl MI, Lind MV, Nielsen RL, Frøkiær H, et al. 2019. Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial. Gut. 68(1):83–93. doi:10.1136/gutjnl-2017-314786.
   PubMed Web of Science ®Google Scholar
• Rogero MM, Calder PC. 2018. Obesity, inflammation, toll-like receptor 4 and fatty acids. In Nutrients. 10(4):432. doi:10.3390/nu10040432.
   PubMed Web of Science ®Google Scholar
• Rohr MW, Narasimhulu CA, Rudeski-Rohr TA, Parthasarathy S. 2020. Negative effects of a high-fat diet on intestinal permeability: a review. Adv Nutr. 11(1):77–91. doi:10.1093/advances/nmz061.
   PubMed Web of Science ®Google Scholar
• Ruan Y, Sun J, He J, Chen F, Chen R, Chen H. 2015. Effect of probiotics on glycemic control: a systematic review and meta-analysis of randomized, controlled trials. PLoS One. 10(7):e0132121. doi:10.1371/journal.pone.0132121.
   PubMed Web of Science ®Google Scholar
• Sabatino A, Regolisti G, Cosola C, Gesualdo L, Fiaccadori E. 2017. Intestinal microbiota in type 2 diabetes and chronic kidney disease. Curr Diab Rep. 17(3):16. doi:10.1007/s11892-017-0841-z.
   PubMed Web of Science ®Google Scholar
• Sabico S, Al-Mashharawi A, Al-Daghri NM, Yakout S, Alnaami AM, Alokail MS, McTernan PG. 2017. Effects of a multi-strain probiotic supplement for 12 weeks in circulating endotoxin levels and cardiometabolic profiles of medication naïve T2DM patients: a randomized clinical trial. J Transl Med. 15(1):249. doi:10.1186/s12967-017-1354-x.
   PubMedGoogle Scholar
• Sabico S, Al-Mashharawi A, Al-Daghri NM, Wani K, Amer OE, Hussain DS, Ahmed Ansari MG, Masoud MS, Alokail MS, McTernan P G. 2019. Effects of a 6-month multi-strain probiotics supplementation in endotoxemic, inflammatory and cardiometabolic status of T2DM patients: A randomized, double-blind, placebo-controlled trial. Clin Nutr. 38(4):1561–1569. doi:10.1016/j.clnu.2018.08.009.
   Google Scholar
• Salamon D, Sroka-Oleksiak A, Kapusta P, Szopa M, Mrozińska S, Ludwig-Słomczyńska AH, Wołkow PP, Bulanda M, Klupa T, Małecki MT, et al. 2018. Characteristics of gut microbiota in adult patients with type 1 and type 2 diabetes based on next‑generation sequencing of the 16S rRNA gene fragment. Pol Arch Intern Med. 128(6):336–343. doi:10.20452/PAMW.4246.
   PubMedGoogle Scholar
• Salari A, Mahdavi-Roshan M, Kheirkhah J, Ghorbani Z. 2021. Probiotics supplementation and cardiometabolic risk factors: a new insight into recent advances, potential mechanisms, and clinical implications. PharmaNutrition. 16:100261. doi:10.1016/j.phanu.2021.100261.
   Web of Science ®Google Scholar
• Samah S, Ramasamy K, Lim SM, Neoh CF. 2016. Probiotics for the management of type 2 diabetes mellitus: a systematic review and meta-analysis. Diabetes Res Clin Pract. 118:172–182. doi:10.1016/j.diabres.2016.06.014.
   PubMed Web of Science ®Google Scholar
• Sangaran PG, Ibrahim ZA, Chik Z, Mohamed Z, Ahmadiani A. 2020. Lipopolysaccharide Pre-conditioning Attenuates Pro-inflammatory Responses and Promotes Cytoprotective Effect in Differentiated PC12 Cell Lines via Pre-activation of Toll-Like Receptor-4 Signaling Pathway Leading to the Inhibition of Caspase-3/Nuclear Fact. Front Cell Neurosci. 14:598453. doi:10.3389/fncel.2020.598453.
   PubMed Web of Science ®Google Scholar
• Sato J, Kanazawa A, Azuma K, Ikeda F, Goto H, Komiya K, Kanno R, Tamura Y, Asahara T, Takahashi T, Nomoto K, Yamashiro Y, Watada H. 2017. Probiotic reduces bacterial translocation in type 2 diabetes mellitus: A randomised controlled study. Sci Rep. 7(1):1–10. doi:10.1038/s41598-017-12535-9.
   Google Scholar
• Scheithauer TPM, Rampanelli E, Nieuwdorp M, Vallance BA, Verchere CB, van Raalte DH, Herrema H. 2020. Gut microbiota as a trigger for metabolic inflammation in obesity and type 2 diabetes. Front Immunol. 11:571731. doi:10.3389/fimmu.2020.571731.
   PubMed Web of Science ®Google Scholar
• Sfairopoulos D, Liatis S, Tigas S, Liberopoulos E. 2018. Clinical pharmacology of glucagon-like peptide-1 receptor agonists. Hormones. 17(3):333–350. doi:10.1007/s42000-018-0038-0.
   PubMedGoogle Scholar
• Shen G, Wu J, Ye BC, Qi N. 2021. Gut microbiota-derived metabolites in the development of diseases. Can J Infect Dis Med Microbiol. 2021:6658674–6658677. doi:10.1155/2021/6658674.
   PubMed Web of Science ®Google Scholar
• Shin NR, Lee JC, Lee HY, Kim MS, Whon TW, Lee MS, Bae JW. 2014. An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice. Gut. 63(5):727–735. doi:10.1136/gutjnl-2012-303839.
   PubMed Web of Science ®Google Scholar
• Simon MC, Strassburger K, Nowotny B, Kolb H, Nowotny P, Burkart V, Zivehe F, Hwang JH, Stehle P, Pacini G, et al. 2015. Intake of lactobacillus reuteri improves incretin and insulin secretion in Glucose-Tolerant humans: a proof of concept. Diabetes Care. 38(10):1827–1834. doi:10.2337/dc14-2690.
   PubMed Web of Science ®Google Scholar
• Soleimani A, Zarrati Mojarrad M, Bahmani F, Taghizadeh M, Ramezani M, Tajabadi-Ebrahimi M, Jafari P, Esmaillzadeh A, Asemi Z. 2017. Probiotic supplementation in diabetic hemodialysis patients has beneficial metabolic effects. Kidney Int. 91(2):435–442. doi:10.1016/j.kint.2016.09.040.
   Google Scholar
• Sousa-Pinto B, Gonçalves L, Rodrigues AR, Tomada I, Almeida H, Neves D, Gouveia AM. 2016. Characterization of TGF-β expression and signaling profile in the adipose tissue of rats fed with high-fat and energy-restricted diets. J Nutr Biochem. 38:107–115. doi:10.1016/J.JNUTBIO.2016.07.017.
   PubMed Web of Science ®Google Scholar
• Suez J, Zmora N, Segal E, Elinav E. 2019. The pros, cons, and many unknowns of probiotics. In Nat Med. 25(5):716–729. doi:10.1038/s41591-019-0439-x.
   PubMed Web of Science ®Google Scholar
• Sun J, Buys NJ. 2016. Glucose- and glycaemic factor-lowering effects of probiotics on diabetes: a meta-analysis of randomised placebo-controlled trials. Br J Nutr. 115(7):1167–1177. doi:10.1017/S0007114516000076.
   PubMed Web of Science ®Google Scholar
• Tajabadi-Ebrahimi M, Sharifi N, Farrokhian A, Raygan F, Karamali F, Razzaghi R, Taheri S, Asemi Z. 2017. A randomized controlled clinical trial investigating the effect of synbiotic administration on markers of insulin metabolism and lipid profiles in overweight type 2 diabetic patients with coronary heart disease. Exp Clin Endocrinol Diabetes. 125(1):21–27. doi:10.1055/s-0042-105441.
   PubMed Web of Science ®Google Scholar
• Tan J, McKenzie C, Potamitis M, Thorburn AN, Mackay CR, Macia L. 2014. The role of short-chain fatty acids in health and disease. Adv Immunol. 121:91–119. doi:10.1016/B978-0-12-800100-4.00003-9.
   PubMed Web of Science ®Google Scholar
• Tang C, Ahmed K, Gille A, Lu S, Gröne HJ, Tunaru S, Offermanns S. 2015. Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes. Nat Med. 21(2):173–177. doi:10.1038/nm.3779.
   PubMed Web of Science ®Google Scholar
• Teede HJ, Misso ML, Costello MF, Dokras A, Laven J, Moran L, Piltonen T, Norman RJ, Andersen M, Azziz R, et al. 2018. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Fertil Steril. 110(3):364–379. doi:10.1016/j.fertnstert.2018.05.004.
   PubMed Web of Science ®Google Scholar
• Tian S, Li X, Wang Y, Lu Y. 2021. The protective effect of sulforaphane on type II diabetes induced by high-fat diet and low-dosage streptozotocin. Food Sci Nutr. 9(2):747–756. doi:10.1002/fsn3.2040.
   PubMed Web of Science ®Google Scholar
• Toejing P, Khat-Udomkiri N, Intakhad J, Sirilun S, Chaiyasut C, Lailerd N. 2020. Putative Mechanisms Responsible for the Antihyperglycemic Action of Lactobacillus paracasei HII01 in Experimental Type 2 Diabetic Rats. Nutrients. 12(10):3015. doi:10.3390/NU12103015.
   PubMed Web of Science ®Google Scholar
• Torres S, Fabersani E, Marquez A, Gauffin-Cano P. 2019. Adipose tissue inflammation and metabolic syndrome. The proactive role of probiotics. Eur J Nutr. 58(1):27–43. doi:10.1007/S00394-018-1790-2.
   PubMed Web of Science ®Google Scholar
• Trepanowski JF, Mey J, Varady KA. 2015. Fetuin-A: a novel link between obesity and related complications. Int J Obes. 39(5):734–741. doi:10.1038/ijo.2014.203.
   Web of Science ®Google Scholar
• Venkataraman R, Jose P, Jose J. 2019. Impact of probiotics on health-related quality of life in Type II diabetes mellitus: a randomized single-blind, placebo-controlled study. J Nat Sc Biol Med. 10(1):2. doi:10.4103/jnsbm.JNSBM_31_18.
   Google Scholar
• Vergès B. 2015. Pathophysiology of diabetic dyslipidaemia: where are we? Diabetologia. 58(5):886–899. doi:10.1007/s00125-015-3525-8.
   PubMed Web of Science ®Google Scholar
• Voidarou C, Antoniadou M, Rozos G, Tzora A, Skoufos I, Varzakas T, Lagiou A, Bezirtzoglou E. 2020. Fermentative Foods: microbiology, Biochemistry, Potential Human Health Benefits and Public Health Issues. Foods. 10(1):69. doi:10.3390/FOODS10010069.
   PubMed Web of Science ®Google Scholar
• Wang G, Li X, Zhao J, Zhang H, Chen W. 2017. Lactobacillus casei CCFM419 attenuates type 2 diabetes via a gut microbiota dependent mechanism. Food Funct. 8(9):3155–3164. doi:10.1039/c7fo00593h.
   PubMed Web of Science ®Google Scholar
• Wang G, Liu J, Xia Y, Ai L. 2021. Probiotics-based interventions for diabetes mellitus: a review. Food Biosci. 43:101172. doi:10.1016/j.fbio.2021.101172.
   Web of Science ®Google Scholar
• Wang G, Si Q, Yang S, Jiao T, Zhu H, Tian P, Wang L, Li X, Gong L, Zhao J, et al. 2020. Lactic acid bacteria reduce diabetes symptoms in mice by alleviating gut microbiota dysbiosis and inflammation in different manners. Food Funct. 11(7):5898–5914. doi:10.1039/C9FO02761K.
   PubMed Web of Science ®Google Scholar
• Wang J, Qin J, Li Y, Cai Z, Li S, Zhu J, Zhang F, Liang S, Zhang W, Guan Y, et al. 2012. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature. 490(7418):55–60. doi:10.1038/nature11450.
   PubMed Web of Science ®Google Scholar
• Wang J, Tang H, Zhang C, Zhao Y, Derrien M, Rocher E, Van-Hylckama Vlieg JE, Strissel K, Zhao L, Obin M, et al. 2015. Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice. Isme J. 9(1):1–15. doi:10.1038/ismej.2014.99.
   PubMed Web of Science ®Google Scholar
• Wang L, Shang Q, Guo W, Wu X, Wu L, Wu L, Chen T. 2020. Evaluation of the hypoglycemic effect of probiotics via directly consuming glucose in intestines of STZ-induced diabetic mice and glucose water-induced diabetic mice. J Funct Foods. 64:103614. doi:10.1016/j.jff.2019.103614.
   Web of Science ®Google Scholar
• Wang SZ, Yu YJ, Adeli K. 2020. Role of gut microbiota in neuroendocrine regulation of carbohydrate and lipid metabolism via the microbiota-gut-brain-liver axis. Microorganisms. 8(4):527. doi:10.3390/microorganisms8040527.
   PubMed Web of Science ®Google Scholar
• Wang Y, Dilidaxi D, Wu Y, Sailike J, Sun X, Nabi XH. 2020. Composite probiotics alleviate type 2 diabetes by regulating intestinal microbiota and inducing GLP-1 secretion in db/db mice. Biomed Pharmacother. 125:109914. doi:10.1016/J.BIOPHA.2020.109914.
   PubMed Web of Science ®Google Scholar
• Wang Y, Wu Y, Sailike J, Sun X, Abuduwaili N, Tuoliuhan H, Yusufu M, Nabi XH. 2020. Fourteen composite probiotics alleviate type 2 diabetes through modulating gut microbiota and modifying M1/M2 phenotype macrophage in db/db mice. Pharmacol Res. 161:105150. doi:10.1016/J.PHRS.2020.105150.
   PubMed Web of Science ®Google Scholar
• Wen L, Duffy A. 2017. Factors influencing the gut microbiota, inflammation, and type 2 diabetes. J Nutr. 147(7):1468S–1475S. doi:10.3945/jn.116.240754.
   PubMed Web of Science ®Google Scholar
• Wilms E, Gerritsen J, Smidt H, Besseling-Van Der Van Vaart I, Rijkers GT, Fuentes ARG, Masclee AAM, Troost FJ. 2016. Effects of supplementation of the synbiotic Ecologic® 825/FOS P6 on intestinal barrier function in healthy humans: A randomized controlled trial. P LoS ONE. 11(12). doi:10.1371/journal.pone.0167775.
   Google Scholar
• Wu H, Tremaroli V, Schmidt C, Lundqvist A, Olsson LM, Krämer M, Gummesson A, Perkins R, Bergström G, Bäckhed F. 2020. The Gut Microbiota in Prediabetes and Diabetes: a Population-Based Cross-Sectional Study. Cell Metab. 32(3):379–390.e3. doi:10.1016/J.CMET.2020.06.011.
   PubMed Web of Science ®Google Scholar
• Xu Y, Wang N, Tan HY, Li S, Zhang C, Feng Y. 2020. Function of Akkermansia muciniphila in Obesity: interactions With Lipid Metabolism, Immune Response and Gut Systems. Front Microbiol. 11:219. doi:10.3389/fmicb.2020.00219.
   PubMed Web of Science ®Google Scholar
• Yamamoto Y, Miyatsuka T, Sasaki S, Miyashita K, Kubo F, Shimo N, Takebe S, Watada H, Kaneto H, Matsuoka TA, et al. 2017. Preserving expression of Pdx1 improves β-cell failure in diabetic mice. Biochem Biophys Res Commun. 483(1):418–424. doi:10.1016/J.BBRC.2016.12.128.
   PubMed Web of Science ®Google Scholar
• Yan F, Li N, Shi J, Li H, Yue Y, Jiao W, Wang N, Song Y, Huo G, Li B. 2019. Lactobacillus acidophilus alleviates type 2 diabetes by regulating hepatic glucose, lipid metabolism and gut microbiota in mice. Food Funct. 10(9):5804–5815. doi:10.1039/C9FO01062A.
   PubMed Web of Science ®Google Scholar
• Yao K, Zeng L, He Q, Wang W, Lei J, Zou X. 2017. Effect of probiotics on glucose and lipid metabolism in type 2 diabetes mellitus: A meta-analysis of 12 randomized controlled trials. Med Sci Monit. 23:3044–3053. doi:10.12659/MSM.902600.
   PubMed Web of Science ®Google Scholar
• Yassour M, Lim MY, Yun HS, Tickle TL, Sung J, Song Y-M, Lee K, Franzosa EA, Morgan XC, Gevers D, et al. 2016. Sub-clinical detection of gut microbial biomarkers of obesity and type 2 diabetes. Genome Med. 8(1):17. doi:10.1186/s13073-016-0271-6.
   PubMed Web of Science ®Google Scholar
• Ying W, Fu W, Lee YS, Olefsky JM. 2020. The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities. Nat Rev Endocrinol. 16(2):81–90. doi:10.1038/s41574-019-0286-3.
   PubMed Web of Science ®Google Scholar
• Yuan J, Hu YJ, Zheng J, Kim JH, Sumerlin T, Chen Y, He Y, Zhang C, Tang J, Pan Y, et al. 2020. Long-term use of antibiotics and risk of type 2 diabetes in women: a prospective cohort study. Int J Epidemiol. 49(5):1572–1581. doi:10.1093/IJE/DYAA122.
   PubMed Web of Science ®Google Scholar
• Zhang L, Carmody RN, Kalariya HM, Duran RM, Moskal K, Poulev A, Kuhn P, Tveter KM, Turnbaugh PJ, Raskin I, et al. 2018. Grape proanthocyanidin-induced intestinal bloom of Akkermansia muciniphila is dependent on its baseline abundance and precedes activation of host genes related to metabolic health. J Nutr Biochem. 56:142–151. doi:10.1016/j.jnutbio.2018.02.009.
   PubMed Web of Science ®Google Scholar
• Zhang Q, Wu Y, Fei X. 2016. Effect of probiotics on glucose metabolism in patients with type 2 diabetes mellitus: A meta-analysis of randomized controlled trials. Medicina. 52(1):28–34. doi:10.1016/j.medici.2015.11.008.
   PubMedGoogle Scholar
• Zheng J, Wittouck S, Salvetti E, Franz CMAP, Harris HMB, Mattarelli P, O’Toole PW, Pot B, Vandamme P, Walter J, et al. 2020. A taxonomic note on the genus Lactobacillus: description of 23 novel genera, emended description of the genus Lactobacillus beijerinck 1901, and union of Lactobacillaceae and Leuconostocaceae. Int J Syst Evol Microbiol. 70(4):2782–2858. doi:10.1099/IJSEM.0.004107.
   PubMed Web of Science ®Google Scholar
• Zhu Y, Liu Q, Zhou Z, Ikeda Y. 2017. PDX1, Neurogenin-3, and MAFA: critical transcription regulators for beta cell development and regeneration. Stem Cell Res Ther. 8(1):240. doi:10.1186/s13287-017-0694-z.
   PubMedGoogle Scholar