Botanicals as promising antimicrobial agents for enhancing oral health: a comprehensive review

References

• Aagaard K, Ma J, Antony KM, Ganu R, Petrosino J, Versalovic J. 2014. The placenta harbors a unique microbiome. Sci Transl Med. 6(237):237e265. doi: 10.1126/scitranslmed.3008599.
   Web of Science ®Google Scholar
• Adamczak A, Ożarowski M, Karpiński TM. 2019. Antibacterial activity of some flavonoids and organic acids widely distributed in plants. J Clin Med. 9(1):109. doi: 10.3390/jcm9010109.
   PubMed Web of Science ®Google Scholar
• Agarwal P, Nagesh L. 2010. Evaluation of the antimicrobial activity of various concentrations of Tulsi (Ocimum sanctum) extract against Streptococcus mutans: an: in vitro: study. Indian J Dent Res. 21(3):357–359. doi: 10.4103/0970-9290.70800.
   PubMedGoogle Scholar
• Aggarwal V, Tuli HS, Tania M, Srivastava S, Ritzer EE, Pandey A, Aggarwal D, Barwal TS, Jain A, Kaur G, et al. 2022. Molecular mechanisms of action of epigallocatechin gallate in cancer: recent trends and advancement. In: Seminars in cancer biology. Vol. 80. Cambridge: Academic Press; p. 256–275. doi: 10.1016/j.semcancer.2020.05.011.
   Google Scholar
• Agrawal S, Popli DB, Sircar K, Chowdhry A. 2020. A review of the anticancer activity of Azadirachta indica (Neem) in oral cancer. J Oral Biol Craniofac Res. 10(2):206–209. doi: 10.1016/j.jobcr.2020.04.007.
   PubMedGoogle Scholar
• Ahuja A, Tyagi PK, Kumar M, Sharma N, Prakash S, Chandran D, Dhumal S, Rais N, Singh S, Dey A, et al. 2022. Botanicals and oral stem cell mediated regeneration: a paradigm shift from artificial to biological replacement. Cells. 11(18):2792. doi: 10.3390/cells11182792.
   PubMed Web of Science ®Google Scholar
• Ajmera N, Chatterjee A, Goyal V. 2013. Aloe vera: its effect on gingivitis. J Indian Soc Periodontol. 17(4):435–438. doi: 10.4103/0972-124X.118312.
   PubMedGoogle Scholar
• Alabsi AM, Lim KL, Paterson IC, Ali-Saeed R, Muharram BA. 2016. Cell cycle arrest and apoptosis induction via modulation of mitochondrial integrity by bcl-2 family members and caspase dependence in Dracaena cinnabari—Treated H400 human oral squamous cell carcinoma. Biomed Res Int. 2016:4904016–4904013. doi: 10.1155/2016/4904016.
   PubMed Web of Science ®Google Scholar
• Al-Azzawi AJ. 2015. The antibacterial effect of herbal alternative, green tea, and Salvadora persica (Siwak) extracts on Enterococcus faecalis. JBCD. 27(2):1–5. doi: 10.12816/0015287.
   Google Scholar
• Alcerito T, Barbo FE, Negri G, Santos DY, Meda CI, Young MCM, Chávez D, Blatt CT. 2002. Folicular epicuticular wax of Arrabidaea brachypoda: flavonoids and antifungal activity. Biochem. Syst. Ecol. 30(7):677–683. doi: 10.1016/S0305-1978(01)00149-1.
   Web of Science ®Google Scholar
• Ali MZ, Elbaz WFA, Adouri S, Desai V, Fanas SA, Thomas B, Varma SR. 2022. Effect of a novel betel leaf dentifrice on commonly seen oral hygiene parameters—A randomized clinical crossover study. Dent J. 10(9):166. doi: 10.3390/dj10090166.
   Google Scholar
• Ali NA, Abbas MJ, Al-Bayaty FH. 2015. Evaluation of potential effect of menthol solution on oral hygiene status of dental students in a university in Iraq. Trop J Pharm Res. 14(4):687–692. doi: 10.4314/tjpr.v14i4.18.
   Web of Science ®Google Scholar
• Almadi EM, Almohaimede AA. 2018. Natural products in endodontics. Saudi Med J. 39(2):124–130. doi: 10.15537/smj.2018.2.21038.
   PubMed Web of Science ®Google Scholar
• Almeida TC, da Silva GN, de Souza DV, de Moraes Malinverni AC, Aguiar O, Estadella D, Ribeiro DA. 2021. Resveratrol effects in oral cancer cells: a comprehensive review. Med Oncol. 38(8):1–10. doi: 10.1007/s12032-021-01548-0.
   Web of Science ®Google Scholar
• Al-Mubarak S, Ciancio S, Baskaradoss JK. 2014. Epidemiology and diagnosis of periodontal diseases: recent advances and emerging trends. Int J Dent. 2014:953646–953642. doi: 10.1155/2014/953646.
   PubMedGoogle Scholar
• Alves TMDA, Ribeiro FL, Kloos H, Zani CL. 2001. Polygodial, the fungitoxic component from the Brazilian medicinal plant polygonum punctatum. Mem Inst Oswaldo Cruz. 96(6):831–833. doi: 10.1590/s0074-02762001000600016.
   PubMed Web of Science ®Google Scholar
• Alviano WS, Alviano DS, Diniz CG, Antoniolli AR, Alviano CS, Farias LM, Carvalho MAR, Souza MM, Bolognese AM. 2008. In vitro antioxidant potential of medicinal plant extracts and their activities against oral bacteria based on Brazilian folk medicine. Arch Oral Biol. 53(6):545–552. doi: 10.1016/j.archoralbio.2007.12.001.
   PubMed Web of Science ®Google Scholar
• Amadi ES, Oyeka CA, Onyeagba RA, Ugbogu OC, Okoli I. 2007. Antimicrobial screening of Breynia nivosus and Ageratum conyzoides against dental caries organisms. J of Biological Sciences. 7(2):354–358. doi: 10.3923/jbs.2007.354.358.
   Google Scholar
• Amoian B, Moghadamnia AA, Barzi S, Sheykholeslami S, Rangiani A. 2010. Salvadora persica extract chewing gum and gingival health: improvement of gingival and probe-bleeding index. Complement Ther Clin Pract. 16(3):121–123. doi: 10.1016/j.ctcp.2009.11.002.
   PubMedGoogle Scholar
• Anand G, Ravinanthan M, Basaviah R, Shetty AV. 2015. In vitro antimicrobial and cytotoxic effects of Anacardium occidentale and Mangifera indica in oral care. J Pharm Bioallied Sci. 7(1):69–74. doi: 10.4103/0975-7406.148780.
   PubMed Web of Science ®Google Scholar
• Ankola A, Kumar V, Thakur S, Singhal R, Smitha T, Sankeshwari R. 2020. Anticancer and antiproliferative efficacy of a standardized extract of Vaccinium macrocarpon on the highly differentiating oral cancer KB cell line athwart the cytotoxicity evaluation of the same on the normal fibroblast L929 cell line. J Oral Maxillofac Pathol. 24(2):258–265. doi: 10.4103/jomfp.JOMFP_129_20.
   PubMedGoogle Scholar
• Annamalai G, Suresh K. 2018. Shogaol attenuates inflammation, cell proliferation via modulate NF-B and AP-1 oncogenic signaling in 7,12-dimethylbenz[a]anthracene induced oral carcinogenesis. Biomed Pharmacother. 98:484–490. doi: 10.1016/j.biopha.2017.12.009.
   PubMed Web of Science ®Google Scholar
• Arantes A, da Silva Carvalho E, Medeiros EA, Farhat CK, Mantese OC. 2004. Pedriatic risk of mortality and hospital infection. Infect Control Hosp Epidemiol. 25(9):783–785. doi: 10.1086/502478.
   PubMed Web of Science ®Google Scholar
• Arumuganainar D, Subramanian G, Basavarajappa S, Hashem MI, Arun KV, Balaji SK, Yadalam PK, Venkidasamy B, Vinayagam R. 2023. Bioactive efficacy of identified phytochemicals solasodine, lupeol and quercetin from Solanumx anthocarpum against the RgpB Protein of Porphyromonas gingivalis—A molecular docking and simulation analysis. Processes. 11(7):1887. doi: 10.3390/pr11071887.
   Web of Science ®Google Scholar
• Badria FA, Zidan OA. 2004. Natural products for dental caries prevention. J Med Food. 7(3):381–384. doi: 10.1089/jmf.2004.7.381.
   PubMed Web of Science ®Google Scholar
• Bajaj N, Tandon S. 2011. The effect of triphala and chlorhexidine mouthwash on dental plaque, gingival inflammation, and microbial growth. Int J Ayurveda Res. 2(1):29–36. doi: 10.4103/0974-7788.83188.
   PubMedGoogle Scholar
• Bakri IM, Douglas CWI. 2005. Inhibitory effect of garlic extract on oral bacteria. Arch Oral Biol. 50(7):645–651. doi: 10.1016/j.archoralbio.2004.12.002.
   PubMed Web of Science ®Google Scholar
• Balappanavar AY, Sardana V, Singh M. 2013. Comparison of the effectiveness of 05% tea 2% neem and 02% chlorhexidine mouthwashes on oral health: a randomized control trial. Indian J Dent Res. 24(1):26–34. doi: 10.4103/0970-9290.114933.
   PubMedGoogle Scholar
• Barnett M, Ciancio S, Mather M. 1980. The modified papillary bleeding index-comparison with gingival index during the resolution of gingivitis. J. Prev. Dent. 6:135–138.
   Google Scholar
• Bearfield C, Davenport ES, Sivapathasundaram V, Allaker RP. 2002. Possible association between amniotic fluid microorganism infection and microflora in the mouth. BJOG. 109(5):527. doi: 10.1111/j.1471-0528.2002.01349.x.
   PubMed Web of Science ®Google Scholar
• Beauséjour A, Grenier D, Goulet JP, Deslauriers N. 1998. Proteolitic activation of the interleukin 1b precursor by Candida albicans. Infect Immun. 66(2):676–681. doi: 10.1128/IAI.66.2.676-681.1998.
   PubMed Web of Science ®Google Scholar
• Bhattacharya, S., Virani, S., Zavro, M., & Haas, G. J. 2003. Inhibition of streptococcus mutans and other oral streptococci by hop (Humulus Lupulus L.) constituents. Economic Botany. 57(1):118–125. doi: 10.1663/0013-0001(2003)057[0118:iosmao]2.0.co;2.
   Google Scholar
• Bidault P, Chandad F, Grenier D. 2007. Risk of bacterial resistance associated with systemic antibiotic therapy in periodontology. J Can Dent Assoc. 73(8):721–725.
   PubMedGoogle Scholar
• Borg M, Rüchel R. 1998. Expression of extracellular acid proteinase by proteolitic Candida spp during experimental infection of oral mucosa. Infect Immun. 56(3):626–631. doi: 10.1128/iai.56.3.626-631.1988.
   Google Scholar
• Botelho MA, dos Santos RA, Martins JG, Carvalho CO, Paz MC, Azenha C, Ruela RS, Queiroz DB, Ruela WS, Marinho G, et al. 2009. Comparative effect of an essential oil mouthrinse on plaque, gingivitis and salivary Streptococcus mutans levels: a double blind randomized study. Phytother Res. 23(9):1214–1219. doi: 10.1002/ptr.2489.
   PubMed Web of Science ®Google Scholar
• Brighenti FL, Luppens SBI, Delbem ACB, Deng DM, Hoogenkamp MA, Gaetti-Jardim E, Dekker HL, Crielaard W, Ten Cate JM. 2008. Effect of Psidium cattleianum leaf extract on Streptococcus mutans viability, protein expression and acid production. Caries Res. 42(2):148–154. doi: 10.1159/000121439.
   PubMed Web of Science ®Google Scholar
• Burdock GA, Carabin IG, Griffiths JC. 2006. Toxicology and pharmacology of sodium ricinoleate. Food Chem Toxicol. 44(10):1689–1698. doi: 10.1016/j.fct.2006.05.007.
   PubMed Web of Science ®Google Scholar
• Campus G, Cagetti MG, Cocco F, Sale S, Sacco G, Strohmenger L, Lingström P. 2011. Effect of a sugar-free chewing gum containing magnolia bark extract on different variables related to caries and gingivitis: a randomized controlled intervention trial. Caries Res. 45(4):393–399. doi: 10.1159/000330234.
   PubMed Web of Science ®Google Scholar
• Carvalho TRB, Tanaka EB, Vilhena AT, Frade PCR, de Souza Fonseca RR, de Souza Rodrigues TM, da Paz Brito M, Silva SG, de Carvalho Junior RN, de Oliveira MS, et al. 2021. Chemical composition, antimicrobial and antifungal activity of Lippia thymoide essential oil in oral pathogens. Braz J Oral Sci. 20:e210219. https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8660219. doi: 10.20396/bjos.v20i00.8660219.
   Google Scholar
• Caufield PW, Dasanayake AP, Li Y. 2001. The antimicrobial approach to caries management. J Dent Educ. 65(10):1091–1095.
   PubMedGoogle Scholar
• Chandrasekaran M, Venkatesalu V. 2004. Antibacterial and antifungal activity of Syzygium jambolonum seeds. J Ethnopharmacol. 91(1):105–108. doi: 10.1016/j.jep.2003.12.012.
   PubMed Web of Science ®Google Scholar
• Chatterjee A, Saluja M, Singh N, Kandwal A. 2011. To evaluate the antigingivitis and antipalque effect of an Azadirachta indica (neem) mouth rinse on plaque induced gingivitis: a double blind, randomized, controlled trial. J Indian Soc Periodontol. 15(4):398–401. doi: 10.4103/0972-124X.92578.
   PubMedGoogle Scholar
• Cheng L, Li J, He L, Zhou X. 2015. Natural products and caries prevention. Caries Res. 49(Suppl 1):38–45. doi: 10.1159/000377734.
   PubMedGoogle Scholar
• Chung JY, Choo JH, Lee MH, Hwang JK. 2006. Anticariogenic activity of macelignan isolated from Myristica frgrans (nutmeg) against Streptococcus mutans. Phytomedicine. 13(4):261–266. doi: 10.1016/j.phymed.2004.04.007.
   PubMed Web of Science ®Google Scholar
• Cordeiro CHG, Sacramento LVSD, Corrêa MA, Pizzolitto AC, Bauab TM. 2006. Analise farmacognostica e atividade antibacteriana de extratos vegetais empregados em formulacao para a higiene bucal. Rev Bras Cienc Farm. 42(3):395–404. doi: 10.1590/S1516-93322006000300008.
   Google Scholar
• Cornejo OE, Lefébure T, Bitar PDP, Lang P, Richards VP, Eilertson K, Do T, Beighton D, Zeng L, Ahn S-J, et al. 2013. Evolutionary and population genomics of the cavity causing bacteria Streptococcus mutans. Mol Biol Evol. 30(4):881–893. doi: 10.1093/molbev/mss278.
   PubMed Web of Science ®Google Scholar
• Corrêa AFS, Andrade LR, Soares MJ. 2002. Elemental composition of acidocalcisomes of Trypanosoma cruzi bloodstream trypomastigote forms. Parasitol Res. 88(10):875–880. doi: 10.1007/s00436-002-0670-z.
   PubMed Web of Science ®Google Scholar
• Cortelli SC, Costa FO, Rode SDM, Haas AN, Andrade AKPD, Pannuti CM, Escobar EC, Almeida ERD, Cortelli JR, Pedrazzi V. 2014. Mouthrinse recommendation for prosthodontic patients. Braz Oral Res. 28:1–9. doi: 10.1590/1807-3107BOR-2014.vol28.0020.
   PubMed Web of Science ®Google Scholar
• Deepavalli A, Gopinath S, Arun KV, Balaji SK. 2023. An in vitro evaluation of the antibacterial efficacy of Solanum xanthocarpum extracts on bacteria from dental plaque biofilm. Cureus. 15(9):e45202.
   PubMed Web of Science ®Google Scholar
• Dewhirst FE, Chen T, Izard J, Paster BJ, Tanner ACR, Yu WH, Lakshmanan A, Wade WG. 2010. The human oral microbiome. J Bacteriol. 192(19):5002–5017. doi: 10.1128/JB.00542-10.
   PubMed Web of Science ®Google Scholar
• Di Berardino L, Della Torre F. 2003. Side effects to castor oil. Allergy. 58(8):826–826. doi: 10.1034/j.1398-9995.2003.00221.x.
   PubMed Web of Science ®Google Scholar
• Didry N, Dubreuil L, Trotin F, Pinkas M. 1998. Antimicrobial activity of aerial parts of Drosera peltata Smith on oral bacteria. J Ethnopharmacol. 60(1):91–96. doi: 10.1016/s0378-8741(97)00129-3.
   PubMed Web of Science ®Google Scholar
• Divaris K, Shungin D, Rodríguez-Cortés A, Basta PV, Roach J, Cho H, Wu D, Ferreira Zandoná AG, Ginnis J, Ramamoorthy S, et al. 2019. The supragingival biofilm in early childhood caries: clinical and laboratory protocols and bioinformatics pipelines supporting metagenomics, metatranscriptomics, and metabolomics studies of the oral microbiome. Methods Mol Biol. 1922:525–548. doi: 10.1007/978-1-4939-9012-2_40.
   PubMedGoogle Scholar
• Djilas SM, Markov SL, Cvetković DD, Canadanović-Brunet JM, Cetković GS, Tumbas VT. 2006. Antimicrobial and free radical scavenging activities of Teucrium montanum. Fitoterapia. 77(5):401–403. doi: 10.1016/j.fitote.2006.05.019.
   PubMed Web of Science ®Google Scholar
• Dominguez-Bello MG, Costello EK, Contreras M, Magris M, Hidalgo G, Fierer N, Knight R. 2010. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci U S A. 107(26):11971e11975–11971e11975. doi: 10.1073/pnas.1002601107.
   Web of Science ®Google Scholar
• Duarte MCT, Figueira GM, Sartoratto A, Rehder VLG, Delarmelina C. 2005. Anti-Candida activity of Brazilian medicinal plants. J Ethnopharmacol. 97(2):305–311. doi: 10.1016/j.jep.2004.11.016.
   PubMed Web of Science ®Google Scholar
• Elango AV, Vasudevan S, Shanmugam K, Solomon AP, Neelakantan P. 2021. Exploring the anti-caries properties of baicalin against Streptococcus mutans: an in vitro study. Biofouling. 37(3):267–275. doi: 10.1080/08927014.2021.1897789.
   PubMed Web of Science ®Google Scholar
• El-Sherbini GT, Shoukry NM. 2012. In vitro effect of pomegranate peel extract on Trichomonas tenax. Life Sci J. 9:791–797.
   Google Scholar
• Esmaeelian B, Kamrani YY, Amoozegar MA, Rahmani S, Rahimi M, Amanlou M. 2007. Anti-cariogenic properties of malvidin-3,5-diglucoside isolated from Alcea longipedicellata against oral bacteria. Int J Pharmacol. 3(6):468–474. doi: 10.3923/ijp.2007.468.474.
   Google Scholar
• Fani M, Kohanteb J. 2017. In vitro antimicrobial activity of Thymus vulgaris essential oil against major oral pathogens. J Evid Based Complementary Altern Med. 22(4):660–666. doi: 10.1177/2156587217700772.
   PubMedGoogle Scholar
• Farjana HN, Chandrasekaran SC, Gita B. 2014. Effect of oral curcuma gel in gingivitis management – A pilot study. J Clin Diagn Res. 8(12):Zc08–10. doi: 10.7860/JCDR/2014/8784.5235.
   PubMedGoogle Scholar
• Ferrazzano GF, Amato I, Ingenito A, Zarrelli A, Pinto G, Pollio A. 2011. Plant polyphenols and their anti-cariogenic properties: a review. Molecules. 16(2):1486–1507. doi: 10.3390/molecules16021486.
   PubMed Web of Science ®Google Scholar
• Fritz TM, Burg G, Krasovec M. 2001. Allergic contact dermatitis to cosmetics containing Melaleuca alternifolia (tea tree oil). Ann Dermatol Venereol. 128(2):123–126.
   PubMed Web of Science ®Google Scholar
• Gershon H, Shanks L. 1975. Fungitoxicity of 1, 4-naphtoquinones to Candida albicans. Can J Microbiol. 21(9):1317–1321. doi: 10.1139/m75-198.
   PubMed Web of Science ®Google Scholar
• Ghannoum MA, Abu-Elteen KH. 1990. Pathogenicity determinants of Candida. Mycoses. 33(6):265–282. doi: 10.1111/myc.1990.33.6.265.
   PubMed Web of Science ®Google Scholar
• Goncalves GMS, Bottaro M, Nilson AC. 2011. Effect of the Thymus vulgaris essential oil on the growth of Streptococcus mutans. Revista de Ciênciasfarmacêuticasbasica e Aplicada. 32(3):375–380.
   Google Scholar
• Grbic J, Wexler I, Celenti R, Altman J, Saffer A. 2011. A phase II trial of a transmucosal herbal patch for the treatment of gingivitis. J Am Dent Assoc. 142(10):1168–1175. doi: 10.14219/jada.archive.2011.0086.
   PubMed Web of Science ®Google Scholar
• Greene JG, Vermillion JR. 1964. The simplified oral hygiene index. J Am Dent Assoc. 68(1):7–13. doi: 10.14219/jada.archive.1964.0034.
   PubMed Web of Science ®Google Scholar
• Groppo FC, Bergamaschi CDC, Cogo K, Franz-Montan M, Motta RHL, Andrade EDD. 2008. Use of phytotherapy in dentistry. Phytother Res. 22(8):993–998. doi: 10.1002/ptr.2471.
   PubMed Web of Science ®Google Scholar
• Güllüce M, Sökmen M, Daferera D, Ağar G, Ozkan H, Kartal N, Polissiou M, Sökmen A, Sahin F. 2003. In vitro antibacterial, antifungal and antioxidant activities of the essential oil and methanol extracts of herbal parts and callus culture of Satureja hortensis L. J Agric Food Chem. 51(14):3958–3965. doi: 10.1021/jf0340308.
   PubMed Web of Science ®Google Scholar
• Hakim LK, Yazdanian M, Alam M, Abbasi K, Tebyaniyan H, Tahmasebi E, Khayatan D, Seifalian A, Ranjbar R, Yazdanian A. 2021. Biocompatible and biomaterials application in drug delivery system in oral cavity. Evid Based Complementary Altern Med. 2021:1–12. doi: 10.1155/2021/9011226.
   Web of Science ®Google Scholar
• Hamilton-Miller JMT. 2001. Anti-cariogenic properties of tea (Camellia sinensis). J Med Microbiol. 50(4):299–302. doi: 10.1099/0022-1317-50-4-299.
   PubMed Web of Science ®Google Scholar
• Hardie JM. 1992. Oral microbiology: current concepts in the microbiology of dental caries and periodontal disease. Br Dent J. 172(7):271–278. doi: 10.1038/sj.bdj.4807849.
   PubMed Web of Science ®Google Scholar
• He X, Hu W, He J, Guo L, Lux R, Shi W. 2011. Community- based interference against integration of Pseudomonas aeruginosa into human salivary microbial biofilm. Mol Oral Microbiol. 26(6):337–352. doi: 10.1111/j.2041-1014.2011.00622.x.
   PubMed Web of Science ®Google Scholar
• Heydarpour F, Abasabadi M, Shahpiri Z, Vaziri S, Nazari H, Najafi F, Mirzaei M, Farzaei M. 2018. Medicinal plant and their bioactive phytochemicals in the treatment of recurrent aphthous ulcers: a review of clinical trials. Phcog Rev. 12(23):27–39. doi: 10.4103/phrev.phrev_37_17.
   Google Scholar
• Hirasawa M, Takada K, Makimura M, Otake S. 2002. Improvement of periodontal status by green tea catechin using a local delivery system: a clinical pilot study. J Periodontal Res. 37(6):433–438. doi: 10.1034/j.1600-0765.2002.01640.x.
   PubMed Web of Science ®Google Scholar
• Hoegl L, Korting HC, Klebe G. 1999. Inhibitors of aspartic proteases in human diseases: molecular modeling comes of age. Pharmazie. 54(5):319–329.
   PubMed Web of Science ®Google Scholar
• Höfling JF, Mardegan RC, Anibal PC, Furletti VF, Foglio MA. 2011. Evaluation of antifungal activity of medicinal plant extracts against oral Candida albicans and proteinases. Mycopathologia. 172(2):117–124. doi: 10.1007/s11046-011-9404-z.
   PubMed Web of Science ®Google Scholar
• Howshigan J, Perera K, Samita S, Rajapakse PS. 2015. The effects of an ayurvedic medicinal toothpaste on clinical, microbiological and oral hygiene parameters in patients with chronic gingivitis: a double-blind, randomised, placebocontrolled, parallel allocation clinical trial. Ceylon Med J. 60(4):126–132. doi: 10.4038/cmj.v60i4.8219.
   PubMedGoogle Scholar
• Hu JP, Takahashi N, Yamada T. 2000. Coptidis rhizome inhibits growth and proteases of oral bacteria. Oral Dis. 6(5):297–302. doi: 10.1111/j.1601-0825.2000.tb00142.x.
   PubMed Web of Science ®Google Scholar
• Hube B, Naglik J. 2001. Candida albicans proteinases: resolving the mystery of a gene family. Microbiology. 147(Pt 8):1997–2005. doi: 10.1099/00221287-147-8-1997.
   PubMedGoogle Scholar
• Huntley AL, Thompson CJ, Ernst E. 2005. The safety of herbal medicinal products derived from Echinacea species: a systematic review. Drug Saf. 28(5):387–400. doi: 10.2165/00002018-200528050-00003.
   PubMed Web of Science ®Google Scholar
• Hussein SAM, Barakat HH, Merfort I, Nawwar MAM. 1997. Tannins from the leaves of Punica granatum. Phytochemist. 45(4):819–823. doi: 10.1016/S0031-9422(96)00888-6.
   Web of Science ®Google Scholar
• Hwang JK, Chung JY, Baek NI, Park JH. 2004. Isopanduratin a from Kaempferia pandurata as an active antibacterial agent against cariogenic Streptococcus mutans. Int J Antimicrob Agents. 23(4):377–381. doi: 10.1016/j.ijantimicag.2003.08.011.
   PubMed Web of Science ®Google Scholar
• Hwang JK, Shim JS, Pyun YR. 2000. Antibacterial activity of xanthorrhizol from Curcuma xanthorrhiza against oral pathogens. Fitoterapia. 71(3):321–323. doi: 10.1016/s0367-326x(99)00170-7.
   PubMedGoogle Scholar
• Iauk L, Lo Bue AM, Milazzo I, Rapisarda A, Blandino G. 2003. Antibacterial activity of medicinal plant extracts against periodontopathic bacteria. Phytother Res. 17(6):599–604. doi: 10.1002/ptr.1188.
   PubMed Web of Science ®Google Scholar
• Iscan G, Kirimer N, Kurkcuoglu M, Baser KHC, Demirci F. 2002. Antimicrobial screening of Mentha piperita essential oils. J Agric Food Chem. 50:3943–3946.
   PubMed Web of Science ®Google Scholar
• Jalil V, Khan M, Haider SZ, Shamim S. 2022. Investigation of the antibacterial, anti-Biofilm, and antioxidative effect of Piper betle leaf extract against Bacillus gaemokensis MW067143 isolated from dental caries, an in vitro-in silico approach. Microorganisms. 10(12):2485. doi: 10.3390/microorganisms10122485.
   PubMed Web of Science ®Google Scholar
• Janardhanan S, Mahendra J, Kasthuri R, Mahendra L, Srinivasan S, Hussain S. 2021. Anticariogenic and anticarcinogenic effects of Garcinia mangostana pericarp extracts on cariogenic bacteria and on cancer cell lines with molecular docking study. Int J Pharm Res. 13(2):1151.
   PubMedGoogle Scholar
• Jantarat J, Malhotra W, Sutimuntanakul S. 2013. Efficacy of grapefruit, tangerine, lime, and lemon oils as solvents for softening gutta-percha in root canal retreatment procedures. J Investig Clin Dent. 4(1):60–63. doi: 10.1111/j.2041-1626.2012.00143.x.
   PubMedGoogle Scholar
• Jayashankar S, Panagoda GJ, Amaratunga EA, Perera K, Rajapakse PS. 2011. A randomised double-blind placebo controlled study on the effects of a herbal toothpaste on gingival bleeding, oral hygiene and microbial variables. Ceylon Med J. 56(1):5–9. doi: 10.4038/cmj.v56i1.2887.
   PubMedGoogle Scholar
• Jenabian N, Moghadamnia AA, Karami E, Mir PBA. 2012. The effect of Camellia sinensis (green tea) mouthwash on plaque induced gingivitis: a single-blinded randomized controlled clinical trial. DARU J Pharm Sci. 20:39.
   Web of Science ®Google Scholar
• Jenkinson HF, Lamont RJ. 2005. Oral microbial communities in sickness and in health. Trends Microbiol. 13(12):589–595. doi: 10.1016/j.tim.2005.09.006.
   PubMed Web of Science ®Google Scholar
• Jeon JG, Rosalen PL, Falsetta ML, Koo H. 2011. Natural products in caries research: current (limited) knowledge, challenges and future perspective. Caries Res. 45(3):243–263. doi: 10.1159/000327250.
   PubMed Web of Science ®Google Scholar
• Jia G, Zhi A, Lai PF, Wang G, Xia Y, Xiong Z, Zhang H, Che N, Ai L. 2018. The oral microbiota-a mechanistic role for systemic diseases. Br Dent J. 224(6):447–455. doi: 10.1038/sj.bdj.2018.217.
   PubMed Web of Science ®Google Scholar
• Jia X, Jia L, Mo L, Yuan S, Zheng X, He J, Chen V, Guo Q, Zheng L, Yuan Q, et al. 2019. Berberine ameliorates periodontal bone loss by regulating gut microbiota. J Dent Res. 98(1):107–116. doi: 10.1177/0022034518797275.
   PubMed Web of Science ®Google Scholar
• Jiao Y, Tay FR, Niu LN, Chen JH. 2019. Advancing antimicrobial strategies for managing oral biofilm infections. Int J Oral Sci. 11(3):28. doi: 10.1038/s41368-019-0062-1.
   PubMedGoogle Scholar
• Jiménez E, Fernández L, Marín ML, Martín R, Odriozola JM, Nueno-Palop C, Narbad A, Olivares M, Xaus J, Rodríguez JM. 2005. Isolation of commensal bacteria from umbilical cord blood of healthy neonates born by cesarean section. Curr Microbiol. 51(4):270–274. doi: 10.1007/s00284-005-0020-3.
   PubMed Web of Science ®Google Scholar
• Jiménez E, Marín ML, Martín R, Odriozola JM, Olivares M, Xaus J, Fernández L, Rodríguez JM. 2008. Is meconium from healthy newborns actually sterile? Res Microbiol. 159(3):187–193. doi: 10.1016/j.resmic.2007.12.007.
   PubMed Web of Science ®Google Scholar
• Johnson S, Arjmandi B. 2013. Evidence for anti-cancer properties of blueberries: a mini-review. Anticancer Agents Med Chem. 13(8):1142–1148. doi: 10.2174/18715206113139990137.
   PubMed Web of Science ®Google Scholar
• Juniarti DE, Kusumaningsih T, Juliastuti WS, Soetojo A, Wungsu ND. 2021. Phytochemical analysis and antibacterial activity of purple leaf extract [Graptophyllum pictum (L.) Griff] against Streptococcus mutans. ActaMedicaPhilippina. 55(8):802–806.
   Google Scholar
• Kamal SA, Mohammed GJ, Hameed IH. 2018. Antimicrobial, anti-inflammatory, analgesic potential and cytotoxic activity of Salvadora persica: a review. Indian J Public Health Res Dev. 9(3):393–398. doi: 10.5958/0976-5506.2018.00242.5.
   Google Scholar
• Kamrani YY, Amanlou M, Esmaeelian B, Bidhendi SM, SahebJamei M. 2007. Inhibitory effects of a flavonoid-rich extract of Pistacia vera hull on growth and acid production of bacteria involved in dental plaque. Int J Pharmacol. 3(3):219–226. doi: 10.3923/ijp.2007.219.226.
   Google Scholar
• Karioti A, Vrahimi-Hadjilouca T, Droushiotis D, Rancic A, Hadjipavlou-Litina D, Skaltsa H. 2006. Analysis of the essential oil of Origanum dubium growing wild in Cyprus. Investigation of its antioxidant capacity and antimicrobial activity. Planta Med. 72(14):1330–1334. doi: 10.1055/s-2006-947255.
   PubMed Web of Science ®Google Scholar
• Katariya M, Singh J, Sirdesai A, Bandyopadhyay P. 2023a. In vitro assessment of babool extract, mint and clove oil containing toothpaste on gingivitis causing bacteria. J Adv Microbiol Res. 4(1):128–133. doi: 10.22271/micro.2023.v4.i1b.86.
   Google Scholar
• Katariya M, Singh J, Sirdesai A, Bandyopadhyay P. 2023b. In-vitro assessment of 32 Ayurvrdic herbs containing toothpaste on gingivitis causing bacteria. Int J Pharm Sci Drug Anal. 3(2):34–37.
   Google Scholar
• Katsura H, Tsukiyama RI, Suzuki A, Kobayashi M. 2001. In vitro antimicrobial activities of bakuchiol against oral microorganisms. Antimicrob Agents Chemother. 45(11):3009–3013. doi: 10.1128/AAC.45.11.3009-3013.2001.
   PubMed Web of Science ®Google Scholar
• Kaushik N, Rehani U, Agarwal A, Kaushik M, Adlakha V. 2013. Antimicrobial efficacy of endodontic irrigants against Enterococcus faecalis and Escherichia coli: an in vitro study. Int J Clin Pediatr Dent. 6(3):178–182. doi: 10.5005/jp-journals-10005-1214.
   PubMedGoogle Scholar
• Khairnar MS, Pawar B, Marawar PP, Mani A. 2013. Evaluation of Calendula officinalis as an anti-plaque and anti-gingivitis agent. J Indian Soc Periodontol. 17(6):741–747. doi: 10.4103/0972-124X.124491.
   PubMedGoogle Scholar
• Khalessi AM, Pack AR, Thomson WM, Tompkins GR. 2004. An in vivo study of the plaque control efficacy of Persica: a commercially available herbal mouthwash containing extracts of Salvadora persica. Int Dent J. 54(5):279–283. doi: 10.1111/j.1875-595x.2004.tb00294.x.
   PubMed Web of Science ®Google Scholar
• Khalid M, Hassani D, Bilal M, Butt ZA, Hamayun M, Ahmad A, Huang D, Hussain A. 2017. Identification of oral cavity biofilm forming bacteria and determination of their growth inhibition by Acacia arabica, Tamarixaphylla L. and Meliaazedarach L. medicinal plants. Arch Oral Biol. 81:175–185. doi: 10.1016/j.archoralbio.2017.05.011.
   PubMedGoogle Scholar
• Kilian M, Chapple IL, Hannig M, Marsh PD, Meuric V, Pedersen AM, Tonetti MS, Wade WG, Zaura E. 2016. The oral microbiome – An update for oral healthcare professionals. Br Dent J. 221(10):657–666. doi: 10.1038/sj.bdj.2016.865.
   PubMed Web of Science ®Google Scholar
• Klages U, Weber AG, Wehrbein H. 2005. Approximal plaque and gingival sulcus bleeding in routine dental care patients: relations to life stress, somatization and depression. J Clin Periodontol. 32(6):575–582. doi: 10.1111/j.1600-051X.2005.00716.x.
   PubMed Web of Science ®Google Scholar
• Kleinberg I. 2002. A mixed-bacteria ecological approach to understanding the role of the oral bacteria in dental caries causation: an alternative to Streptococcus mutans and the specific-plaque hypothesis. Crit Rev Oral Biol Med. 13(2):108–125. doi: 10.1177/154411130201300202.
   PubMedGoogle Scholar
• Koh T, Murakami Y, Tanaka S, Machino M, Onuma H, Kaneko M, Sugimoto M, Soga T, Tomita M, Sakagami H. 2013. Changes of metabolic profiles in an oral squamous cell carcinoma cell line induced by eugenol. In Vivo. 27:233–243.
   PubMed Web of Science ®Google Scholar
• Koo H, Bowen WH. 2014. Candida albicans and Streptococcus mutans: a potential synergistic alliance to cause virulent tooth decay in children. Future Microbiol. 9(12):1295–1297. doi: 10.2217/fmb.14.92.
   PubMed Web of Science ®Google Scholar
• Koo H, Jeon JG. 2009. Naturally occurring molecules as alternative therapeutic agents against cariogenic biofilms. Adv Dent Res. 21(1):63–68. doi: 10.1177/0895937409335629.
   PubMedGoogle Scholar
• Koo H, Schobel B, Scott-Anne K, Watson G, Bowen WH, Cury JA, Rosalen PL, Park YK. 2005. Apigenin and tt-farnesol with fluoride effects on S. mutans biofilms and dental caries. J Dent Res. 84(11):1016–1020. doi: 10.1177/154405910508401109.
   PubMed Web of Science ®Google Scholar
• Krahwinkel T, Willershausen B. 2005. The effect of sugar-free green tea chew candies on the degree of inflammation of the gingiva. Eur J Med Res. 5:463–467.
   Google Scholar
• Kumar M, Prakash S, Lorenzo JM, Chandran D, Dhumal S, Dey A, Senapathy M, Rais N, Singh S, Kalkreuter P, Damale RD. (2022). Apitherapy and periodontal disease: insights into in vitro, in vivo, and clinical studies. Antioxidants. 11(5), p.823. doi: 10.3390/antiox11050823.
   Web of Science ®Google Scholar
• Kwon YS, Lim ES, Kim HM, Hwang YC, Lee KW, Min KS. 2015. Genipin, a cross-linking agent, promotes odontogenic differentiation of human dental pulp cells. J Endod. 41(4):501–507. doi: 10.1016/j.joen.2014.12.002.
   PubMed Web of Science ®Google Scholar
• Lakshmi T, Ezhilarasan D, Vijayaragavan R, Bhullar SK, Rajendran R. 2017. Acacia catechu ethanolic bark extract induces apoptosis in human oral squamous carcinoma cells. J Adv Pharm Technol Res. 8(4):143–149. doi: 10.4103/japtr.JAPTR_73_17.
   PubMedGoogle Scholar
• Lakshmi T, Krishnan V, Rajendran R, Madhusudhanan N. 2015. Azadirachta indica: a herbal panacea in dentistry - An update. Pharmacogn Rev. 9(17):41–44. doi: 10.4103/0973-7847.156337.
   PubMedGoogle Scholar
• Lang NP, Adler R, Joss A, Nyman S. 1999. Absence of bleeding on probing an indicator of periodontal stability. J Clin Periodontol. 17(10):714–721. doi: 10.1111/j.1600-051x.1990.tb01059.x.
   Google Scholar
• Lee SI, Kim SY, Park KR, Kim EC. 2016. Baicalein promotes angiogenesis and odontobalstic differentiation via BMP and Wnt pathways in human dental pulp cells. Am J Chin Med. 44(7):1457–1472. doi: 10.1142/S0192415X16500816.
   PubMed Web of Science ®Google Scholar
• Lee SS, Zhang W, Li Y. 2004. The antimicrobial potential of 14 natural herbal dentifrices: results of an in vitro diffusion method study. J Am Dent Assoc. 135(8):1133–1141. doi: 10.14219/jada.archive.2004.0372.
   PubMed Web of Science ®Google Scholar
• Leroy R, Eaton KA, Savage A. 2010. Methodological issues in epidemiological studies of periodontitis-how can it be improved? BMC Oral Health. 10(1):8. doi: 10.1186/1472-6831-10-8.
   PubMedGoogle Scholar
• Lim Y, Totsika M, Morrison M, Punyadeera C. 2017. Oral microbiome: a new biomarker reservoir for oral and oropharyngeal cancers. Theranostics. 7(17):4313–4321. doi: 10.7150/thno.21804.
   PubMed Web of Science ®Google Scholar
• Liu XT, Pan Q, Shi Y, Williams ID, Sung HHY, Zhang Q, Liang JY, Ip NY, Min ZD. 2006. Ent-rosane and labdane diterpenoids from Sagittaria sagittifolia and their antibacterial activity against three oral pathogens. J Nat Prod. 69(2):255–260. doi: 10.1021/np050479e.
   PubMed Web of Science ®Google Scholar
• Liu XT, Shi Y, Yu B, Williams ID, Sung HHY, Zhang Q, Liang JY, Ip NY, Min ZD. 2007. Antibacterial diterpenoids from Sagittaria pygmaea. Planta Med. 73(1):84–90. doi: 10.1055/s-2006-951773.
   PubMed Web of Science ®Google Scholar
• Löe H. 1967. The gingival index, the plaque index and the retention index systems. J. Periodont. 38(6):610–616. doi: 10.1902/jop.1967.38.6.610.
   Web of Science ®Google Scholar
• Madanakumar AJ, Lawarence B, Manoj GS, Kumaraswamy M. 2018. Purified Anthocyanin from in vitro culture of Bridelia retusa (L.) Spreng. capable of inhibiting the growth of human oral squamous cell carcinoma cells. PJ. 10(3):559–566. doi: 10.5530/pj.2018.3.91.
   Google Scholar
• Makarem A, Khalili N, Asodeh R. 2007. Efficacy of barberry aqueous extracts dental gel on control of plaque and gingivitis. Acta Med Iran. 45:91–94.
   Google Scholar
• Malik, A., Aftab, M., Shaukat, M. S., Khalid, B., Hameed, M., & Ahmed, R. A. 2021. Comparative clinical effects of salvadora persica oral rinse and a phenolic commercial mouth wash on human oral health; An invivo randomized trial. Journal of the Pakistan Dental Association. 30(2).
   Google Scholar
• Manoharan S, Balakrishnan S, Menon VP, Alias LM, Reena AR. 2009. Chemopreventive & efficacy of curcumin and piperine during 7,12-dimethylbenz [a]anthracene-induced hamster buccal pouch carcinogenesis. Singapore Med J. 50(2):139–146.
   PubMed Web of Science ®Google Scholar
• Mardegan RdC, Klein MI, Golvea MB, Rodrigues JAO, Gonçalves RB, Höfling JF. 2006. Biotyping and genotyping diversity among oral Candida albicans strains from caries free and caries activity healthy children. Braz J Microbiol. 37(1):26–32. doi: 10.1590/S1517-83822006000100005.
   Web of Science ®Google Scholar
• Mark Welch JL, Rossetti BJ, Rieken CW, Dewhirst FE, Borisy GG. 2016. Biogeography of a human oral microbiome at the micron scale. Proc Natl Acad Sci U S A. 113(6):E791–800. doi: 10.1073/pnas.1522149113.
   PubMed Web of Science ®Google Scholar
• Marsh PD, Head DA, Devine DA. 2015. Ecological approaches to oral biofilms: control without killing. Caries Res. 49(Suppl 1):46–54. doi: 10.1159/000377732.
   PubMed Web of Science ®Google Scholar
• Marsh PD, Martin MV. 1999. The resident oral microflora. In: Marsh PD, Martin VM, editors. Oral microbiology. Woburn: Reed Educational and Professional Publishing; p. 7–33.
   Google Scholar
• McCullough MJ, Farah CS. 2008. The role of alcohol in oral carcinogenesis with particular reference to alcohol containing mouthwashes. Aust Dent J. 53(4):302–305. doi: 10.1111/j.1834-7819.2008.00070.x.
   PubMed Web of Science ®Google Scholar
• McCullough MJ, Ross BC, Reade PC. 1996. Candida albicans: a review of its history, taxonomy, epidemiology, virulence attributes, and methods of strain differentiation. Int J Oral Maxillofac Surg. 25(2):136–144. doi: 10.1016/s0901-5027(96)80060-9.
   PubMed Web of Science ®Google Scholar
• Mekhemar M, Hassan Y, Dörfer C. 2020. Nigella sativa and thymoquinone: a natural blessing for periodontal therapy. Antioxidants. 9(12):1260. doi: 10.3390/antiox9121260.
   Web of Science ®Google Scholar
• Menezes SM, Cordeiro LN, Viana GS. 2006. Punica granatum (pomegranate) extract is active against dental plaque. J Herb Pharmacother. 6(2):79–92.
   PubMedGoogle Scholar
• Messina BA. 2006. Herbal supplements: facts and myths – talking to your patients about herbal supplements. J Perianesth Nurs. 21(4):268–278. doi: 10.1016/j.jopan.2006.05.004.
   PubMedGoogle Scholar
• Metushaj A. 2015. Epidemiology of periodontal diseases. Anglisticum. 3:136–140.
   Google Scholar
• Moghaddam A, Ranjbar R, Yazdanian M, Tahmasebi E, Alam M, Abbasi K, Hosseini ZS, Tebyaniyan H. 2022. The current antimicrobial and antibiofilm activities of synthetic/herbal/biomaterials in dental application. Biomed Res Int. 2022:8856025–8856026. doi: 10.1155/2022/8856025.
   PubMed Web of Science ®Google Scholar
• Mosaddad SA, Hussain A, Tebyaniyan H. 2023. Green alternatives as antimicrobial agents in mitigating periodontal diseases: a narrative review. Microorganisms. 11(5):1269. doi: 10.3390/microorganisms11051269.
   PubMed Web of Science ®Google Scholar
• Mosaddad SA, Tahmasebi E, Yazdanian A, Rezvani MB, Seifalian A, Yazdanian M, Tebyanian H. 2019. Oral microbial biofilms: an update. Eur J Clin Microbiol Infect Dis. 38(11):2005–2019. doi: 10.1007/s10096-019-03641-9.
   PubMed Web of Science ®Google Scholar
• Motallaei MN, Yazdanian M, Tebyanian H, Tahmasebi E, Alam M, Abbasi K, Seifalian A, Ranjbar R, Yazdanian A. 2021. The current strategies in controlling oral diseases by herbal and chemical materials. Evid Based Complement Alternat Med. 2021:3423001–3423022. doi: 10.1155/2021/3423001.
   PubMed Web of Science ®Google Scholar
• Motallaei MN, Yazdanian M, Tebyaniyan H, Tahmasebi E, Alam M, Abbasi K, Ranjbar R, Yazdanian A, Moghaddam MM, Sedighian H. 2021. Evaluation of cytotoxic and antimicrobial properties of Iranian sea salts: an in vitro study. Evid Based Complement Altern Med. 2021:1–7. doi: 10.1155/2021/8495596.
   Google Scholar
• Moulari B, Lboutounne H, Chaumont JP, Guillaume Y, Millet J, Pellequer Y. 2006. Potentiation of the bactericidal activity of Harungana madagascariensis Lam. ex Poir. (Hypericaceae) leaf extract against oral bacteria using poly (D, L-lactide-co-glycolide) nanoparticles: in vitro study. Acta Odontol Scand. 64(3):153–158. doi: 10.1080/00016350500483152.
   PubMed Web of Science ®Google Scholar
• Mühlemann H, Son S. 1971. Gingival sulcus bleeding–a leading symptom in initial gingivitis. Helv Odontol Acta. 15(2):107–113.
   PubMedGoogle Scholar
• Muley B, Khadabadi S, Banarase N. 2009. Phytochemical constituents and pharmacological activities of Calendula officinalis Linn. (Asteraceae): a review. Trop. J. Pharmaceut. Res. 8:455–465.
   Web of Science ®Google Scholar
• Nadar BG, Usha GV, Lakshminarayan N. 2020. Comparative evaluation of efficacy of 4% Tulsi extract (Ocimum sanctum), fluoridated and placebo dentifrices against gingivitis and plaque among 14–15 years school children in Davangere City, India–A triple blinded randomized clinical trial. Contemp Clin Dent. 11(1):67–75. doi: 10.4103/ccd.ccd_109_19.
   PubMed Web of Science ®Google Scholar
• Nagata H, Inagaki Y, Tanaka M, Ojima M, Kataoka K, Kuboniwa M, Nishida N, Shimizu K, Osawa K, Shizukuishi S. 2008. Effect of eucalyptus extract chewing gum on periodontal health: a double-masked, randomized trial. J Periodontol. 79(8):1378–1385. doi: 10.1902/jop.2008.070622.
   PubMed Web of Science ®Google Scholar
• Nóbrega DRM, Santos RL, Soares RSC, Alves PM, Medeiros ACD, Pereira JV. 2015. A randomized, controlled clinical trial on the clinical and microbiological efficacy of Punica granatum Linn. mouthwash. Pesqui Bras Odontopediatria Clín Integr. 15(1):301–308. doi: 10.4034/PBOCI.2015.151.32.
   Google Scholar
• Nostro A, Cannatelli MA, Crisafi G, Musolino AD, Procopio F, Alonzo V. 2004. Modifications of hydrophobicity, in vitro adherence and cellular aggregation of Streptococcus mutans by Helichrysum italicum extract. Lett Appl Microbiol. 38(5):423–427. doi: 10.1111/j.1472-765X.2004.01509.x.
   PubMed Web of Science ®Google Scholar
• Oberlies NH, Burgess JP, Navarro HA, Pinos RE, Fairchild CR, Peterson RW, Soejarto DD, Farnsworth NR, Kinghorn AD, Wani MC, et al. 2002. Novel bioactive clerodane diterpenoids from the leaves and twigs of Casearia sylvestris. J Nat Prod. 65(2):95–99. doi: 10.1021/np010459m.
   PubMed Web of Science ®Google Scholar
• Odds FC. 1992. Candida infections in AIDS patients. Int J STD AIDS. 3(3):157–160. doi: 10.1177/095646249200300301.
   PubMed Web of Science ®Google Scholar
• Offenbacher S, Katz V, Fertik G, Collins J, Boyd D, Maynor G, McKaig R, Beck J. 1996. Periodontal infection as a possible risk factor for preterm low birth weight. J Periodontol. 67:1103–1113. doi: 10.1902/jop.1996.67.10s.1103.
   PubMed Web of Science ®Google Scholar
• Ok, E., Adanir, N., & Ozturk, T. 2015. Antibacterial and smear layer removal capability of oregano extract solution. European Journal of Dentistry. 9(1):20–24. doi: 10.4103/1305-7456.149633.
   Google Scholar
• Pai MR, Acharya LD, Udupa N. 2004. Evaluation of antiplaque activity of Azadirachta indica leaf extract gel–a 6-week clinical study. J Ethnopharmacol. 90(1):99–103. doi: 10.1016/j.jep.2003.09.035.
   PubMed Web of Science ®Google Scholar
• Panzani R, Johansson SG. 1986. Results of skin test and RAST in allergy to a clinically potent allergen (castor bean). Clin Allergy. 16(3):259–266. doi: 10.1111/j.1365-2222.1986.tb00773.x.
   PubMedGoogle Scholar
• Park KM, You JS, Lee HY, Baek NI, Hwang JK. 2003. Kuwanon G: an antibacterial agent from the rootbark of Morus alba against oral pathogens. J Ethnopharmacol. 84(2-3):181–185. doi: 10.1016/s0378-8741(02)00318-5.
   PubMed Web of Science ®Google Scholar
• Pascual ME, Slowing K, Carretero E, Mata DS, Villar A. 2001. Lippia: traditional uses, chemistry and pharmacology: a review. J Ethnopharmacol. 76(3):201–214. doi: 10.1016/s0378-8741(01)00234-3.
   PubMed Web of Science ®Google Scholar
• Pauletti PM, Castro-Gamboa I, Siqueira Silva DH, Young MCM, Tomazela DM, Eberlin MN, da Silva Bolzani V. 2003. New antioxidant C-glucosylxanthones from the stems of Arrabidaea samydoides. J Nat Prod. 66(10):1384–1387. doi: 10.1021/np030100t.
   PubMed Web of Science ®Google Scholar
• Penha, C.V., Bezerra, L.M. (2000). Concanavaliin A-binding cell wall antigens of Sporotrix schenckii: a serological study. Med Mycol, 1. 38, 1–7. doi: 10.1080/mmy.38.1.1.7.
   PubMedGoogle Scholar
• Philip N, Leishman S, Bandara HMHN, Walsh L. 2020. Growth inhibitory effects of antimicrobial natural products against cariogenic and health-associated oral bacterial species. Oral Health Prev Dent. 18(3):537–542.
   PubMed Web of Science ®Google Scholar
• Pop A, Bogdan C, Fizesan I, Iurian S, Carpa R, Bacali C, Vlase L, Benedec D, Moldovan ML. 2022. In vitro evaluation of biological activities of canes and pomace extracts from several varieties of Vitis vinifera L. for inclusion in freeze-drying mouthwashes. Antioxidants. 11(2):218. doi: 10.3390/antiox11020218.
   Web of Science ®Google Scholar
• Popa M, Măruțescu L, Oprea E, Bleotu C, Kamerzan C, Chifiriuc MC, Grădișteanu Pircalabioru G. 2020. In vitro evaluation of the antimicrobial and immunomodulatory activity of culinary herb essential oils as potential perioceutics. Antibiotics. 9(7):428. doi: 10.3390/antibiotics9070428.
   Google Scholar
• Pradeep A, Agarwal E, Bajaj P, Naik S, Shanbhag N, Uma S. 2012. Clinical and microbiologic effects of commercially available gel and powder containing Acacia arabica on gingivitis. Australian Dental Journal. 57(3):312–318. Portico. doi: 10.1111/j.1834-7819.2012.01714.x.
   Google Scholar
• Prueksakorn A, Puasiri S, Ruangsri S, Makeudom A, Sastraruji T, Krisanaprakornkit S, Chailertvanitkul P. 2016. The preservative effect of Thai propolis extract on the viability of human periodontal ligament cells. Dent Traumatol. 32(6):495–501. doi: 10.1111/edt.12292.
   PubMed Web of Science ®Google Scholar
• Quigley GA, Hein JW. 1962. Comparative cleansing efficiency of manual and power brushing. J Am Dent Assoc. 65(1):26–29. doi: 10.14219/jada.archive.1962.0184.
   PubMed Web of Science ®Google Scholar
• Radha MH, Laxmipriya NP. 2015. Evaluation of biological properties and clinical effectiveness of Aloe vera: a systematic review. J Tradit Complement Med. 5(1):21–26. doi: 10.1016/j.jtcme.2014.10.006.
   PubMedGoogle Scholar
• Radvar M, Moeintaghavi A, Tafaghodi M, Ghanbari H, Fatemi K, Mokhtari MR, Najafi F, Hoseinipour Z, Dastmalchi P, Farazi F. 2016. Clinical efficacy of an herbal mouth wash composed of Salix alba, Malva sylvestrais and Althaea officinalis in chronic periodontitis patients. J Herb Med. 6(1):24–27. doi: 10.1016/j.hermed.2016.01.001.
   Web of Science ®Google Scholar
• Raju S, Krishnan AV, Nair MR, Richard A. 2023. Evaluation of the effects of Albizia lebbeck bark extracts on the cariogenic properties of Streptococcus mutans. Oral Maxillofac Pathol J. 14(1):36–48.
   Web of Science ®Google Scholar
• Ray TL, Payne CD, Morrow BJ. 1991. Candida albicans acid proteinase: characterization and role in candidiasis. Adv Exper Med Biol. 306:173–183.
   PubMedGoogle Scholar
• Ray TL, Payne CD. 1988. Scanning electron microscopy of epidermal adherence and cavitation in murine candidiasis: a role for Candida acid proteinase. Infect Immun. 56(8):1942–1949. doi: 10.1128/iai.56.8.1942-1949.1988.
   PubMed Web of Science ®Google Scholar
• Razak FA, Othman RY, Rahim ZH. 2006. The effect of Piper betle and Psidium guajava extracts on the cell-surface hydrophobicity of selected early settlers of dental plaque. J Oral Sci. 48(2):71–75. doi: 10.2334/josnusd.48.71.
   PubMedGoogle Scholar
• Roopa D, Singh S, Gupta S, Pandey Y, Goswami A, Johari S. 2016. Curcumin: a herbal approach in the management of gingivitis. Rama Univ J Dent Sci. 3:1–5.
   Google Scholar
• Rukayadi Y, Kim KH, Hwang JK, Yanti. 2008. In vitro anti-biofilm activity of macelignan isolated from Myristica fragrans Houtt. against oral primary colonizer bacteria. Phytother Res. 22(3):308–312. doi: 10.1002/ptr.2312.
   PubMed Web of Science ®Google Scholar
• Safiaghdam H, Oveissi V, Bahramsoltani R, Farzaei MH, Rahimi R. 2018. Medicinal plants for gingivitis: a review of clinical trials. Iran J Basic Med Sci. 21(10):978–991. doi: 10.22038/IJBMS.2018.31997.7690.
   PubMed Web of Science ®Google Scholar
• Sahni PS, Gillespie MJ, Botto RW, Otsuka AS. 2002. In vitro testing of xylitol as an anticariogenic agent. Gen Dent. 50(4):340–343.
   PubMedGoogle Scholar
• Saimbi CS, Shubh N, Kapoor KK, Kaushal S. 2009. Clinical effect of Juglansregia on developing dental plaque. JICDRO. 1(3):1–4.
   Google Scholar
• Sampaio-Maia B, Caldas IM, Pereira ML, Pérez-Mongiovi D, Araujo R. 2016. The oral microbiome in health and its implication in oral and systemic diseases. Adv Appl Microbiol. 97:171–210. doi: 10.1016/bs.aambs.2016.08.002.
   PubMed Web of Science ®Google Scholar
• Sampaio-Maia B, Monteiro-Silva F. 2014. Acquisition and maturation of oral microbiome throughout childhood: an update. Dent Res J. 11(3):291–301.
   PubMedGoogle Scholar
• Sasaki H, Matsumoto M, Tanaka T, Maeda M, Nakai M, Hamada S, Ooshima T. 2004. Antibacterial activity of polyphenol components in oolong tea extract against Streptococcus mutans. Caries Res. 38(1):2–8. doi: 10.1159/000073913.
   PubMed Web of Science ®Google Scholar
• Sasi M, Kumar S, Kumar M, Thapa S, Prajapati U, Tak Y, Changan S, Saurabh V, Kumari S, Kumar A, Hasan M. (2021). Garlic (Allium sativum L.) bioactives and its role in alleviating oral pathologies. Antioxidants. 10(11):1847. doi: 10.3390/antiox10111847.
   Web of Science ®Google Scholar
• Sateriale D, Facchiano S, Colicchio R, Pagliuca C, Varricchio E, Paolucci M, Volpe MG, Salvatore P, Pagliarulo C. 2020. In vitro synergy of polyphenolic extracts from honey, myrtle and pomegranate against oral pathogens, S. mutans and R. dentocariosa. Front Microbiol. 11:1465. doi: 10.3389/fmicb.2020.01465.
   PubMed Web of Science ®Google Scholar
• Sato M, Fujiwara S, Tsuchiya H, Fujii T, Iinuma M, Tosa H, Ohkawa Y. 1991. Flavones with antibacterial activity against cariogenic bacteria. J Ethnopharmacol. 54(2-3):171–176. doi: 10.1016/s0378-8741(96)01464-x.
   Google Scholar
• Sato M, Tanaka H, Fujiwara S, Hirata M, Yamaguchi R, Etoh H, Tokuda C. 2003. Antibacterial property of isoflavonoids isolated from Erythrina variegata against cariogenic oral bacteria. Phytomedicine. 10(5):427–433. doi: 10.1078/0944-7113-00225.
   PubMed Web of Science ®Google Scholar
• Schlafer S, Ibsen CJS, Birkedal H, Nyvad B. 2017. Calcium- phosphate-osteopontin particles reduce biofilm formation and pH drops in in situ grown dental biofilms. Caries Res. 51(1):26–33. doi: 10.1159/000451064.
   PubMed Web of Science ®Google Scholar
• Schmuch J, Beckert S, Brandt S, Löhr G, Hermann F, Schmidt TJ, Beikler T, Hensel A. 2015. Extract from Rumex acetosa L. for prophylaxis of periodontitis: inhibition of bacterial in vitro adhesion and of gingipains of Porphyromonas gingivalis by epicatechin-3-O-(4β→ 8)-epicatechin-3-O-gallate (procyanidin-B2-di-gallate). PLoS ONE. 10(3):e0120130. doi: 10.1371/journal.pone.0120130.
   PubMed Web of Science ®Google Scholar
• Shan Z, Yang G, Xiang W, Pei-Jun W, Bin Z. 2014. Effects of resveratrol on oral squamous cell carcinoma (OSCC) cells in vitro. J Cancer Res Clin Oncol. 140(3):371–374. doi: 10.1007/s00432-013-1575-1.
   PubMed Web of Science ®Google Scholar
• Sharangi A. 2009. Medicinal and therapeutic potentialities of tea (Camellia sinensis l.)–a review. Food Res Int. 42(5-6):529–535. doi: 10.1016/j.foodres.2009.01.007.
   Web of Science ®Google Scholar
• Sharma R, Hebbal M, Ankola AV, Murugaboopathy V, Shetty SJ. 2014. Effect of two herbal mouthwashes on gingival health of school children. J Tradit Complement Med. 4(4):272–278. doi: 10.4103/2225-4110.131373.
   PubMedGoogle Scholar
• Shen CC, Ni CL, Shen YC, Huang YL, Kuo CH, Wu TS, Chen CC. 2008. Phenolic constituents from the stem bark of Magnolia officinalis. J Nat Prod. 72(1):168–171. doi: 10.1021/np800494e.
   Web of Science ®Google Scholar
• Silva MLA, Coímbra HS, Pereira AC, Almeida VA, Lima TC, Costa ES, Vinhólis AHC, Royo VA, Silva R, Filho AAS, et al. 2007. Evaluation of Piper cubeba extract, (-)-cubebin and its semisynthetic derivatives against oral pathogens. Phytother Res. 21(5):420–422. doi: 10.1002/ptr.2088.
   PubMed Web of Science ®Google Scholar
• Silva PV, Guedes DFC, Nakadi FV, Pécora JD, Cruz-Filho AM. 2013. Chitosan: a new solution for removal of smear layer after root canal instrumentation. Int Endod J. 46(4):332–338. doi: 10.1111/j.1365-2591.2012.02119.x.
   PubMed Web of Science ®Google Scholar
• Singh AK, Sharma NK, Mishra N, Mahajan A, Krishnan A, Rajpoot R, Kumar JA, Pandey A. 2023. Effects of curcumin on oral cancer at molecular level: A systematic review. Nat J Maxillofac Sur. 14(1):9.
   PubMedGoogle Scholar
• Singh V, Singh R, Kujur PK, Singh RP. 2020. Combination of resveratrol and quercetin causes cell growth inhibition, DNA damage, cell cycle arrest, and apoptosis in oral cancer cells. Assay Drug Dev Technol. 18(5):226–238. doi: 10.1089/adt.2020.972.
   PubMed Web of Science ®Google Scholar
• Siqueira JF, Rôças IN. 2013. Microbiology and treatment of acute apical abscesses. Clin Microbiol Rev. 26(2):255–273. doi: 10.1128/CMR.00082-12.
   PubMed Web of Science ®Google Scholar
• Sojakova M, Liptajova D, Borovsky M, Subik J. 2004. Fluconazole and itraconazole susceptibility of vaginal yeast isolates from Slovakia. Mycopathologia. 157(2):163–169. doi: 10.1023/b:myco.0000020594.35357.b0.
   PubMed Web of Science ®Google Scholar
• Sood S, Nagpal M. 2013. Role of curcumin in systemic and oral health: an overview. J Nat Sci Biol Med. 4(1):3–7. doi: 10.4103/0976-9668.107253.
   PubMedGoogle Scholar
• Sowinski J, Petrone DM, Wachs GN, Chaknis P, Kemp J, Sprosta AA, Devizio W. 2008. Efficacy of three toothbrushes on established gingivitis and plaque. Am J Dent. 21(6):339–345.
   PubMed Web of Science ®Google Scholar
• Stenderup A. 1990. Oral mycology. Acta Odontol Scand. 48(1):3–10. doi: 10.3109/00016359009012728.
   PubMed Web of Science ®Google Scholar
• Sterer N. 2006. Antimicrobial effect of mastic gum methanolic extract against Porphyromonas gingivalis. J Med Food. 9(2):290–292. doi: 10.1089/jmf.2006.9.290.
   PubMed Web of Science ®Google Scholar
• Stohs SJ, Bagchi D. 2015. Antioxidant, anti-inflammatory, and chemoprotective properties of Acacia catechu Heartwood Extracts. Phytother Res. 29(6):818–824. doi: 10.1002/ptr.5335.
   PubMed Web of Science ®Google Scholar
• Stout MJ, Conlon B, Landeau M, Lee I, Bower C, Zhao Q, Roehl KA, Nelson DM, Macones GA, Mysorekar IU. 2013. Identification of intracellular bacteria in the basal plate of the human placenta in term and preterm gestations. Am J Obstet Gynecol. 208(3):226.e1ee7–226.e7. doi: 10.1016/j.ajog.2013.01.018.
   Web of Science ®Google Scholar
• Street RA, Sidana J, Prinsloo G. 2013. Cichoriumintybus: traditional uses, phytochemistry, pharmacology, and toxicology. Evid Based Complement Altern Med. 2013:1–13. doi: 10.1155/2013/579319.
   Web of Science ®Google Scholar
• Subiza J, Subiza JL, Alonso M, Hinojosa M, Garcia R, Jerez M, Subiza E. 1990. Allergic conjunctivitis to chamomile tea. Ann Allergy. 65(2):127–132.
   PubMedGoogle Scholar
• Sukhabogi JR, Shekar BC, Ramana IV, Yadav SS, Kumar GS, Harita N. 2017. Antiplaque efficacy of tooth and gums tonic, Hiora-GA gel, and Spirogyl Gum Paint in comparison with chlorhexidine M gel: a double-blind randomized control trial. Contemp Clin Dent. 8(1):42–47. doi: 10.4103/ccd.ccd_870_16.
   PubMedGoogle Scholar
• Sur S, Ray RB. 2020. Bitter Melon (Momordica charantia), a nutraceutical approach for cancer prevention and therapy. Cancers. 12(8):2064. doi: 10.3390/cancers12082064.
   PubMed Web of Science ®Google Scholar
• Takahashi N, Nyvad B. 2011. The role of bacteria in the caries process: ecological perspectives. J Dent Res. 90(3):294–303. doi: 10.1177/0022034510379602.
   PubMed Web of Science ®Google Scholar
• Tanner AC, Kressirer CA, Faller LL. 2016. Understanding caries from the oral microbiome perspective. J Calif Dent Assoc. 44(7):437–446.
   PubMedGoogle Scholar
• Tebyaniyan H, Hussain A, Vivian M. 2023. Current antibacterial agents in dental bonding systems: a comprehensive overview. Future Microbiol. 18(12):825–844. doi: 10.2217/fmb-2022-0203.
   PubMed Web of Science ®Google Scholar
• Ten Cate JM, Zaura E. 2012. The numerous microbial species in oral biofilms: how could antibacterial therapy be effective? Adv Dent Res. 24(2):108–111. doi: 10.1177/0022034512450028.
   PubMedGoogle Scholar
• Tsuchiya H, Sato M, Iinuma M, Yokoyama J, Ohyama M, Tanaka T, Takase I, Namikawa I. 1994. Inhibition of the growth of cariogenic bacteria in vitro by plant flavanones. Experientia. 50(9):846–849. doi: 10.1007/BF01956469.
   PubMedGoogle Scholar
• Tsui VWK, Wong RWK, Rabie ABM. 2008. The inhibitory effects of naringin on the growth of periodontal pathogens in vitro. Phytother Res. 22(3):401–406. doi: 10.1002/ptr.2338.
   PubMed Web of Science ®Google Scholar
• Tsunozaki M, Lennertz RC, Vilceanu D, Katta S, Stucky CL, Bautista DM. 2013. A ‘toothache tree’alkylamide inhibits Aδmechanonociceptors to alleviate mechanical pain. J Physiol. 591(13):3325–3340. doi: 10.1113/jphysiol.2013.252106.
   PubMed Web of Science ®Google Scholar
• Valones MA, Silva ICG, Gueiros LAM, Leão JC, Caldas AF, Carvalho AAT. 2019. Clinical assessment of rosemary-based toothpaste (Rosmarinusofficinalis Linn.): a randomized controlled double-blind study. Braz Dent J. 30(2):146–151. doi: 10.1590/0103-6440201902164.
   PubMedGoogle Scholar
• Waghmare PF, Chaudhari AU, Karhadkar VM, Jamkhande AS. 2011. Comparative evaluation of turmeric and chlorhexidine gluconate mouthwash in prevention of plaque formation and gingivitis: a clinical and microbiological study. J Contemp Dent Pract. 12(4):221–224. doi: 10.5005/jp-journals-10024-1038.
   PubMedGoogle Scholar
• Wagner H, Kreher B, Lotter H, Hamburger MO, Cordell GA. 1989. Structure determination of new isomeric naphtha [2, 3-b] furan-4, 9-diones from Tabebuia avellanedae by the selective- INEPT technique. Helv Chim Acta. 72(4):659–667. doi: 10.1002/hlca.19890720406.
   Web of Science ®Google Scholar
• Xu X, He J, Xue J, Wang Y, Li K, Zhang K, Guo Q, Liu X, Zhou Y, Cheng L, et al. 2015. Oral cavity contains distinct niches with dynamic microbial communities. Environ Microbiol. 17(3):699–710. doi: 10.1111/1462-2920.12502.
   PubMed Web of Science ®Google Scholar
• Yan Y, Li X, Zhang C, Lv L, Gao B, Li M. 2021. Research progress on antibacterial activities and mechanisms of natural alkaloids: A review. Antibiotics. 10(3):318. doi: 10.3390/antibiotics10030318.
   Google Scholar
• Yang W, Chen X, Li Y, Guo S, Wang Z, Yu X. 2020. Advances in pharmacological activities of terpenoids. Nat Prod Commun. 15(3):1934578X2090355. doi: 10.1177/1934578X20903555.
   Web of Science ®Google Scholar
• Yayli N, Yaşar A, Güleç C, Usta A, Kolayli S, Coşkunçelebi K, Karaoğlu S. 2015. Composition and antimicrobial activity of essential oils from Centaurea sessilis and Centaurea armena. Phytochemist. 66(14):1741–1745. doi: 10.1016/j.phytochem.2005.04.006.
   Google Scholar
• Yazdanian M, Motallaei MN, Tahmasebi E, Tebyaniyan H, Alam M, Abbasi K, Seifalian A, Ranjbar R, Yazdanian A, Hosseini HM, et al. 2022. Chemical characterization and cytotoxic/antibacterial effects of nine Iranian propolis extracts on human fibroblast cells and oral bacteria. Biomed Res Int. 2022:6574997–6574914. doi: 10.1155/2022/6574997.
   PubMed Web of Science ®Google Scholar
• Yazdanian M, Rostamzadeh P, Alam M, Abbasi K, Tahmasebi E, Tebyaniyan H, Ranjbar R, Seifalian A, Moghaddam MM, Kahnamoei MB. 2022. Evaluation of antimicrobial and cytotoxic effects of Echinacea and Arctium extracts and Zataria essential oil. AMB Express. 12(1):75. doi: 10.1186/s13568-022-01417-7.
   PubMed Web of Science ®Google Scholar
• Yazdanian M, Rostamzadeh P, Rahbar M, Alam M, Abbasi K, Tahmasebi E, Tebyaniyan H, Ranjbar R, Seifalian A, Yazdanian A. 2022. The potential application of green-synthesized metal nanoparticles in dentistry: a comprehensive review. Bioinorg Chem Appl. 2022:2311910–2311927. doi: 10.1155/2022/2311910.
   PubMed Web of Science ®Google Scholar
• Yoshikawa M, Murakami T, Kishi A, Kageura T, Matsuda H. 2001. Medicinal flowers. iii. marigold.(1): hypoglycemic, gastric emptying inhibitory, and gastroprotective principles and new oleanane-type triterpene oligoglycosides, calendasaponins a, b, c, and d, from Egyptian Calendula officinalis. Chem Pharm Bull. 49(7):863–870. doi: 10.1248/cpb.49.863.
   PubMed Web of Science ®Google Scholar
• Zainal NS, Gan CP, Lau BF, Yee PS, Tiong KH, Abdul Rahman ZA, Patel V, Cheong SC. 2018. Zerumbone targets the CXCR4-RhoA and PI3K-mTOR signaling axis to reduce motility and proliferation of oral cancer cells. Phytomedicine. 39:33–41. doi: 10.1016/j.phymed.2017.12.011.
   PubMed Web of Science ®Google Scholar
• Zaura E, Nicu EA, Krom BP, Keijser BJ. 2014. Acquiring and maintaining a normal oral microbiome: current perspective. Front Cell Infect Microbiol. 4:85. doi: 10.3389/fcimb.2014.00085.
   PubMed Web of Science ®Google Scholar
• Zhao HS, Chu M, Huang ZW, Yang X, Ran SJ, Hu B, Zhang CP, Liang JP. 2017. Variations in oral microbiota associated with oral cancer. Sci Rep. 7(1):11773. doi: 10.1038/s41598-017-11779-9.
   PubMed Web of Science ®Google Scholar