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Original Articles

Functionalized Magnetite Nanoparticles—Synthesis, Properties, and Bio-Applications

&
Pages 203-215 | Published online: 04 Dec 2007

REFERENCES

  • Jung , C. W. 1995 . Surface-properties of superparamagnetic iron-oxide Mr contrast agents—Ferumoxides, ferumoxtran, ferumoxsil . Magn. Reson. Imaging. , 13 ( 5 ) : 675
  • Tsuji , J. S. , Maynard , A. D. , Howard , P. C. , James , J. T. , Lam , C. W. , Warheit , D. B. and Santamaria , A. B. 2006 . Research strategies for safety evaluation of nanomaterials, part IV: Risk assessment of nanoparticles . Toxicol. Sci. , 89 ( 1 ) : 42
  • Maynard , A. D. 2007 . Nanotechnology: The next big thing, or much ado about nothing? . Ann. Occup. Hyg. , 51 ( 1 ) : 1
  • Neuberger , T. , Schopf , B. , Hofmann , H. , Hofmann , M. and Rechenberg , von B. 2005 . Superparamagnetic nanoparticles for biomedical applications: Possibilities and limitations of a new drug delivery system . J. Magnetism Magnetic Mater. , 293 ( 1 ) : 483
  • Duguet , E. , Vasseur , S. , Mornet , S. and Devoisselle , J. M. 2006 . Magnetic nanoparticles and their applications in medicine . Nanomedicine , 1 ( 2 ) : 157
  • Bulte , J. W. and Kraitchman , D. L. 2004 . Iron oxide MR contrast agents for molecular and cellular imaging . NMR Biomed. , 17 ( 7 ) : 484
  • Gupta , A. K. and Gupta , M. 2005 . Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications . Biomaterials , 26 ( 18 ) : 3995
  • Lu , A. H. , Salabas , E. L. and Schuth , F. 2007 . Magnetic nanoparticles: Synthesis, protection, functionalization, and application . Angew Chem. Int. Ed. Engl. , 46 ( 8 ) : 1222
  • Fleet , M. 1981 . Acta Crystallographica B , 37 : 917
  • Poddar , P. , Fried , T. and Markovich , G. 2002 . First-order metal-insulator transition and spin-polarized tunneling in Fe3O4 nanocrystals . Physical Rev. B , 65 ( 17 )
  • Seo , H. , Ogata , M. and Fukuyama , H. 2002 . Aspects of the Verwey transition in magnetite . Physical Rev. B , 65 ( 8 )
  • Sena , S. P. , Lindley , R. A. , Blythe , H. J. , Sauer , C. , Al-Kafarji , M. and Gehring , G. A. 1997 . Investigation of magnetite thin films produced by pulsed laser deposition . J. Magnetism Magnetic Mater. , 176 ( 2–3 ) : 111
  • Margulies , D. T. , Parker , F. T. , Spada , F. E. , Goldman , R. S. , Li , J. , Sinclair , R. and Berkowitz , A. E. 1996 . Anomalous moment and anisotropy behavior in Fe3O4 films . Physical Rev. B , 53 ( 14 ) : 9175
  • Voogt , F. C. , Palstra , T. T. M. , Niesen , L. , Rogojanu , O. C. , James , M. A. and Hibma , T. 1998 . Superparamagnetic behavior of structural domains in epitaxial ultrathin magnetite films . Physical Rev. B , 57 ( 14 ) : R8107
  • Margulies , D. T. , Parker , F. T. , Rudee , M. L. , Spada , F. E. , Chapman , J. N. , Aitchison , P. R. and Berkowitz , A. E. 1997 . Origin of the anomalous magnetic behaviour in single crystal Fe3O4 films . Physical Rev. Lett. , 79 ( 25 ) : 5162
  • Hibma , T. , Voogt , F. C. , Niesen , L. , Heijden van der , P. A. A. , de Jonge , W. J. M. , Donkers , J. and Zaag van der , P. J. 1999 . Anti-phase domains and magnetism in epitaxial magnetite layers . J. Appl. Phys. , 85 ( 8 ) : 5291
  • Bickford , L. , Brownlow , J. and Penoyer , F. R. 1957 . Magneto-crystalline anisotropy in cobalt-substituted magnetite single crystals . Proc. IEEE. , 104 : 238
  • Medrano , C. , Schlenker , M. , Baruchel , J. , Espeso , J. and Miyamoto , Y. 1999 . Domains in the low-temperature phase of magnetite from synchrotron-radiation x-ray topographs . Physical Rev. B , 59 ( 2 ) : 1185
  • Goya , G. F. , Berquo , T. S. , Fonseca , F. C. and Morales , M. P. 2003 . Static and dynamic magnetic properties of spherical magnetite nanoparticles . J. Appl. Physics , 94 ( 5 ) : 3520
  • Yin , Y. and Alivisatos , A. P. 2005 . Colloidal nanocrystal synthesis and the organic-inorganic interface . Nature , 437 ( 7059 ) : 664
  • Liang , X. , Wang , X. , Zhuang , J. , Chen , Y. T. , Wang , D. S. and Li , Y. D. 2006 . Synthesis of nearly monodisperse iron oxide and oxyhydroxide nanocrystals . Advanced Functional Mater. , 16 ( 14 ) : 1805
  • Sun , S. and Zeng , H. 2002 . Size-controlled synthesis of magnetite nanoparticles . J. Am. Chem. Soc. , 124 ( 28 ) : 8204
  • Sun , S. , Zeng , H. , Robinson , D. B. , Raoux , S. , Rice , P. M. , Wang , S. X. and Li , G. 2004 . Monodisperse MFe2O4 (M = Fe, Co, Mn) nanoparticles . J. Am. Chem. Soc. , 126 ( 1 ) : 273
  • Jun , Y. W. , Huh , Y. M. , Choi , J. S. , Lee , J. H. , Song , H. T. , Kim , S. , Yoon , S. , Kim , K. S. , Shin , J. S. , Suh , J. S. and Cheon , J. 2005 . Nanoscale size effect of magnetic nanocrystals and their utilization for cancer diagnosis via magnetic resonance imaging . J. Am. Chem. Soc. , 127 ( 16 ) : 5732
  • Lee , J. H. , Huh , Y. M. , Jun , Y. W. , Seo , J. W. , Jang , J. T. , Song , H. T. , Kim , S. , Cho , E. J. , Yoon , H. G. , Suh , J. S. and Cheon , J. 2007 . Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging . Nat. Med. , 13 ( 1 ) : 95
  • Song , H. T. , Choi , J. S. , Huh , Y. M. , Kim , S. , Jun , Y. W. , Suh , J. S. and Cheon , J. 2005 . Surface modulation of magnetic nanocrystals in the development of highly efficient magnetic resonance probes for intracellular labeling . J. Am. Chem. Soc. , 127 ( 28 ) : 9992
  • Vallhov , H. , Qin , J. , Johansson , S. M. , Ahlborg , N. , Muhammed , M. A. , Scheynius , A. and Gabrielsson , S. 2006 . The importance of an endotoxin-free environment during the production of nanoparticles used in medical applications . Nano Lett. , 6 ( 8 ) : 1682
  • Thunemann , A. F. , Schutt , D. , Kaufner , L. , Pison , U. and Mohwald , H. 2006 . Maghemite nanoparticles protectively coated with poly(ethylene imine) and poly(ethylene oxide)-block-poly(glutamic acid) . Langmuir , 22 ( 5 ) : 2351
  • Schulze , K. , Koch , A. , Petri-Fink , A. , Steitz , B. , Kamau , S. , Hottiger , M. , Hilbe , M. , Vaughan , L. , Hofmann , M. , Hofmann , H. and von Rechenberg , B. 2006 . Uptake and biocompatibility of functionalized poly(vinylalcohol) coated superparamagnetic maghemite nanoparticles by synoviocytes in vitro . J. Nanosci. Nanotechnol. , 6 ( 9–10 ) : 2829
  • Palmacci , S. and Josephson , L. 1993 . Synthesis of polysaccharide covered superparamagnteic oxide colloids
  • Mikhaylova , M. , Kim , D. K. , Bobrysheva , N. , Osmolowsky , M. , Semenov , V. , Tsakalakos , T. and Muhammed , M. 2004 . Superparamagnetism of magnetite nanoparticles: Dependence on surface modification . Langmuir , 20 ( 6 ) : 2472
  • Petri-Fink , A. , Chastellain , M. , Juillerat-Jeanneret , L. , Ferrari , A. and Hofmann , H. 2005 . Development of functionalized superparamagnetic iron oxide nanoparticles for interaction with human cancer cells . Biomaterials , 26 ( 15 ) : 2685
  • Taupitz , M. , Schnorr , J. , Abramjuk , C. , Wagner , S. , Pilgrimm , H. , Hunigen , H. and Hamm , B. 2000 . New generation of monomer-stabilized very small superparamagnetic iron oxide particles (VSOP) as contrast medium for MR angiography: Preclinical results in rats and rabbits . J. Magn. Reson. Imaging , 12 ( 6 ) : 905
  • Huth , S. , Lausier , J. , Gersting , S. W. , Rudolph , C. , Plank , C. , Welsch , U. and Rosenecker , J. 2004 . Insights into the mechanism of magnetofection using PEI-based magnetofectins for gene transfer . J. Gene Med. , 6 ( 8 ) : 923
  • Berret , J. F. , Schonbeck , N. , Gazeau , F. , El Kharrat , D. , Sandre , O. , Vacher , A. and Airiau , M. 2006 . Controlled clustering of superparamagnetic nanoparticles using block copolymers: Design of new contrast agents for magnetic resonance imaging . J. Am. Chem. Soc. , 128 ( 5 ) : 1755
  • Lee , H. , Lee , E. , Kim do , K. , Jang , N. K. , Jeong , Y. Y. and Jon , S. 2006 . Antibiofouling polymer-coated superparamagnetic iron oxide nanoparticles as potential magnetic resonance contrast agents for in vivo cancer imaging . J. Am. Chem. Soc. , 128 ( 22 ) : 7383
  • Kohler , N. , Sun , C. , Wang , J. and Zhang , M. 2005 . Methotrexate-modified superparamagnetic nanoparticles and their intracellular uptake into human cancer cells . Langmuir , 21 ( 19 ) : 8858
  • Kohler , N. , Fryxell , G. E. and Zhang , M. 2004 . A bifunctional poly(ethylene glycol) silane immobilized on metallic oxide-based nanoparticles for conjugation with cell targeting agents . J. Am. Chem. Soc. , 126 ( 23 ) : 7206
  • Sun , C. , Sze , R. and Zhang , M. 2006 . Folic acid-PEG conjugated superparamagnetic nanoparticles for targeted cellular uptake and detection by MRI . J. Biomed. Mater. Res. A , 78 ( 3 ) : 550
  • Gupta , A. K. and Wells , S. 2004 . Surface-modified superparamagnetic nanoparticles for drug delivery: Preparation, characterization, and cytotoxicity studies . IEEE Transactions on Nanobioscience , 3 ( 1 ) : 66
  • Li , Z. , Wei , L. , Gao , M. Y. and Lei , H. 2005 . One-pot reaction to synthesize biocompatible magnetite nanoparticles . Adv. Mater. , 17 ( 8 ) : 1001
  • Pinna , N. , Grancharov , S. , Beato , P. , Bonville , P. , Antonietti , M. and Niederberger , M. 2005 . Magnetite nanocrystals: Nonaqueous synthesis, characterization, and solubility . Chem. Mater. , 17 ( 11 ) : 3044
  • Martina , M. S. , Fortin , J. P. , Menager , C. , Clement , O. , Barratt , G. , Grabielle-Madelmont , C. , Gazeau , F. , Cabuil , V. and Lesieur , S. 2005 . Generation of superparamagnetic liposomes revealed as highly efficient MRI contrast agents for in vivo imaging . J. Am. Chem. Soc. , 127 ( 30 ) : 10676
  • Son , S. J. , Reichel , J. , He , B. , Schuchman , M. and Lee , S. B. 2005 . Magnetic nanotubes for magnetic-field-assisted bioseparation, biointeraction, and drug delivery . J. Am. Chem. Soc. , 127 ( 20 ) : 7316
  • Lee , J. H. , Jun , Y. W. , Yeon , S. I. , Shin , J. S. and Cheon , J. 2006 . Dual-mode nanoparticle probes for high-performance magnetic resonance and fluorescence imaging of neuroblastoma . Angew Chem. Int. Ed. Engl. , 45 ( 48 ) : 8160
  • Wang , L. Y. , Luo , J. , Fan , Q. , Suzuki , M. , Suzuki , I. S. , Engelhard , M. H. , Lin , Y. H. , Kim , N. , Wang , J. Q. and Zhong , C. J. 2005 . Monodispersed core-shell Fe3O4@Au nanoparticles . J. Physical Chem. B , 109 ( 46 ) : 21593
  • Lyon , J. L. , Fleming , D. A. , Stone , M. B. , Schiffer , P. and Williams , M. E. 2004 . Synthesis of Fe oxide core/Au shell nanoparticles by iterative hydroxylamine seeding . Nano Lett. , 4 ( 4 ) : 719
  • Lu , C. W. , Hung , Y. , Hsiao , J. K. , Yao , M. , Chung , T. H. , Lin , Y. S. , Wu , S. H. , Hsu , S. C. , Liu , H. M. , Mou , C. Y. , Yang , C. S. , Huang , D. M. and Chen , Y. C. 2007 . Bifunctional magnetic silica nanoparticles for highly efficient human stem cell labeling . Nano Lett. , 7 ( 1 ) : 149
  • Ma , D. L. , Jakubek , Z. J. and Simard , B. 2006 . A new approach towards controlled synthesis of multifunctional core-shell nano-architectures: Luminescent and superparamagnetic . J. Nanosci. Nanotechn. , 6 ( 12 ) : 3677
  • Zhao , W. , Gu , J. , Zhang , L. , Chen , H. and Shi , J. 2005 . Fabrication of uniform magnetic nanocomposite spheres with a magnetic core/mesoporous silica shell structure . J. Am. Chem. Soc. , 127 ( 25 ) : 8916
  • Kim , J. , Lee , J. E. , Lee , J. , Yu , J. H. , Kim , B. C. , An , K. , Hwang , Y. , Shin , C. H. , Park , J. G. , Kim , J. and Hyeon , T. 2006 . Magnetic fluorescent delivery vehicle using uniform mesoporous silica spheres embedded with monodisperse magnetic and semiconductor nanocrystals . J. Am. Chem. Soc. , 128 ( 3 ) : 688
  • Deng , Y. , Wang , C. , Shen , X. , Yang , W. , Jin , L. , Gao , H. and Fu , S. 2005 . Preparation, characterization, and application of multistimuli-responsive microspheres with fluorescence-labeled magnetic cores and thermoresponsive shells . Chem. , 11 ( 20 ) : 6006
  • Shi , W. , Zeng , H. , Sahoo , Y. , Ohulchanskyy , T. Y. , Ding , Y. , Wang , Z. L. , Swihart , M. and Prasad , P. N. 2006 . A general approach to binary and ternary hybrid nanocrystals . Nano Lett. , 6 ( 4 ) : 875
  • Hunter , J. R. 2001 . Foundations of colloid science , Oxford University Press .
  • Vonarbourg , A. , Passirani , C. , Saulnier , P. and Benoit , J. P. 2006 . Parameters influencing the stealthiness of colloidal drug delivery systems . Biomater. , 227 ( 24 ) : 4356
  • Yan , X. , Scherphof , G. L. and Kamps , J. A. 2005 . Liposome opsonization . J. Liposome Res. , 15 ( 1–2 ) : 109
  • de Gennes , P. G. 1980 . Macromolecules , 13 : 1069
  • Kingshott , P. , Thissen , H. and Griesser , H. J. 2002 . Effects of cloud-point grafting, chain length, and density of PEG layers on competitive adsorption of ocular proteins . Biomater. , 23 ( 9 ) : 2043
  • Nath , N. , Hyun , J. , Ma , H. and Chilkoti , A. 2004 . Surface engineering strategies for control of protein and cell interactions . Surface Sci. , 570 ( 1–2 ) : 98
  • Kingshott , P. and Griesser , H. J. 1999 . Surfaces that resist bioadhesion . Curr. Opin. Solid State & Mater. Sci. , 4 ( 4 ) : 403
  • Allen , C. , Dos , N. , Santos , R. , Gallagher , G. N. , Chiu , Y. , Li. Shu , W. M. , Johnstone , S. A. , Janoff , A. S. , Mayer , L. D. , Webb , M. S. and Bally , M. B. 2002 . Controlling the physical behavior and biological performance of liposome formulations through use of surface grafted poly(ethylene glycol) . Biosci. Rep. , 22 ( 2 ) : 225
  • Hu , F. Q. , Wei , L. , Zhou , Z. , Ran , Y. L. , Li , Z. and Gao , M. Y. 2006 . Preparation of biocompatible magnetite nanocrystals for in vivo magnetic resonance detection of cancer . Adv. Mater. , 18 ( 19 ) : 2553
  • Xu , C. , Xu , K. , Gu , H. , Zheng , R. , Liu , H. , Zhang , X. , Guo , Z. and Xu , B. 2004 . Dopamine as a robust anchor to immobilize functional molecules on the iron oxide shell of magnetic nanoparticles . J. Am. Chem. Soc. , 126 ( 32 ) : 9938
  • Huh , Y. M. , Jun , Y. W. , Song , H. T. , Kim , S. , Choi , J. S. , Lee , J. H. , Yoon , S. , Kim , K. S. , Shin , J. S. , Suh , J. S. and Cheon , J. 2005 . In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals . J. Am. Chem. Soc. , 127 ( 35 ) : 12387
  • Hong , R. , Fischer , N. O. , Emrick , T. and Rotello , V. M. 2005 . Surface PEGylation and ligand exchange chemistry of FePt nanoparticles for biological applications . Chem. Mater. , 17 ( 18 ) : 4617
  • Mornet , S. , Portier , J. and Duguet , E. 2005 . A method for synthesis and functionalization of ultrasmall superparamagnetic covalent carriers based on maghemite and dextran . J. Magnetism Magnetic Mater. , 293 ( 1 ) : 127
  • Schwalbe , M. , Jorke , C. , Buske , N. , Hoffken , K. , Pachmann , K. and Clement , J. H. 2005 . Selective reduction of the interaction of magnetic nanoparticles with leukocytes and tumor cells by human plasma . J. Magnetism Magnetic Mater. , 293 ( 1 ) : 433
  • Sonvico , F. , Mornet , S. , Vasseur , S. , Dubernet , C. , Jaillard , D. , Degrouard , J. , Hoebeke , J. , Duguet , E. , Colombo , P. and Couvreur , P. 2005 . Folate-conjugated iron oxide nanoparticles for solid tumor targeting as potential specific magnetic hyperthermia mediators: Synthesis, physicochemical characterization, and in vitro experiments . Bioconjug. Chem. , 16 ( 5 ) : 1181
  • Chen , J. , Wu , H. , Han , D. Y. and Xie , C. S. 2006 . Using anti-VEGF McAb and magnetic nanoparticles as double-targeting vector for the radioimmunotherapy of liver cancer . Cancer Lett. , 231 ( 2 ) : 169
  • Lewin , M. , Carlesso , N. , Tung , C. H. , Tang , X. W. , Cory , D. , Scadden , D. T. and Weissleder , R. 2000 . Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells . Nat. Biotechnol. , 18 ( 4 ) : 410
  • Denardo , S. J. , Denardo , G. L. , Miers , L. A. , Natarajan , A. , Foreman , A. R. , Gruettner , C. , Adamson , G. N. and Ivkov , R. 2005 . Development of tumor targeting bioprobes (in-111-Chimeric L6 monoclonal antibody nanoparticles) for alternating magnetic field cancer therapy . Clin. Cancer Res. , 11 ( 19 ) : 7087S
  • Chupa , J. M. , Foster , A. M. , Sumner , S. R. , Madihally , S. V. and Matthew , H. W. 2000 . Vascular cell responses to polysaccharide materials: In vitro and in vivo evaluations . Biomater. , 21 ( 22 ) : 2315
  • McLean , K. M. , Johnson , G. , Chatelier , R. C. , Beumer , G. J. , Steele , J. G. and Griesser , H. J. 2000 . Method of immobilization of carboxymethyl-dextran affects resistance to tissue and cell colonization . Colloids Surf B Biointerfaces , 18 ( 3–4 ) : 221
  • Lemarchand , C. , Gref , R. , Passirani , C. , Garcion , E. , Petri , B. , Muller , R. , Costantini , D. and Couvreur , P. 2006 . Influence of polysaccharide coating on the interactions of nanoparticles with biological systems . Biomater. , 27 ( 1 ) : 108
  • Franzreb , M. , Siemann-Herzberg , M. , Hobley , T. J. and Thomas , O. R. 2006 . Protein purification using magnetic adsorbent particles . Appl. Microbiol. Biotechnol. , 70 ( 5 ) : 505
  • Berensmeier , S. 2006 . Magnetic particles for the separation and purification of nucleic acids . Appl. Microbiol. Biotechnol. , 73 ( 3 ) : 495
  • Osaka , T. , Matsunaga , T. , Nakanishi , T. , Arakaki , A. , Niwa , D. and Iida , H. 2006 . Synthesis of magnetic nanoparticles and their application to bioassays . Anal. Bioanal. Chem. , 384 ( 3 ) : 593
  • Chemla , Y. R. , Grossman , H. L. , Poon , Y. , McDermott , R. , Stevens , R. , Alper , M. D. and Clarke , J. 2000 . Ultrasensitive magnetic biosensor for homogeneous immunoassay . Proc. Natl. Acad. Sci. USA , 97 ( 26 ) : 14268
  • Perez , J. M. , Josephson , L. , Loughlin , O. T. , Hogemann , D. and Weissleder , R. 2002 . Magnetic relaxation switches capable of sensing molecular interactions . Nat. Biotechnol. , 20 ( 8 ) : 816
  • Wang , S. X. , Bae , S. Y. , Li , G. X. , Sun , S. H. , White , R. L. , Kemp , J. T. and Webb , C. D. 2005 . Towards a magnetic microarray for sensitive diagnostics . J. Magnetism Magnetic Mater. , 293 ( 1 ) : 731
  • Lin , P. C. , Chou , P. H. , Chen , S. H. , Liao , H. K. , Wang , K. Y. , Chen , Y. J. and Lin , C. C. 2006 . Ethylene glycol-protected magnetic nanoparticles for a multiplexed immunoassay in human plasma . Small , 2 ( 4 ) : 485
  • Kielhorn , E. , Schofield , K. and Rimm , D. L. 2002 . Use of magnetic enrichment for detection of carcinoma cells in fluid specimens . Cancer , 94 ( 1 ) : 205
  • Koenig , S. H. and Kellar , K. E. 1995 . Theory of 1/T1 and 1/T2 NMRD profiles of solutions of magnetic nanoparticles . Magn. Reson. Med. , 34 ( 2 ) : 227
  • Harisinghani , M. G. , Barentsz , J. , Hahn , P. F. , Deserno , W. M. , Tabatabaei , S. , Van De Kaa , C. H. , De La Rosette , J. and Weissleder , R. 2003 . Noninvasive detection of clinically occult lymph-node metastases in prostate cancer . New Engl. J. Med. , 348 ( 25 ) : 2491
  • Corot , C. , Robert , P. , Idee , J. M. and Port , M. Recent advances in iron oxide nanocrystal technology for medical imaging . Adv. Drug Deliv. Rev. , 58 ( 14 ) 1471
  • Sosnovik , D. E. and Weissleder , R. 2007 . Emerging concepts in molecular MRI . Curr. Opin. Biotechnol. , 18 ( 1 ) : 4
  • Zhao , M. , Beauregard , D. A. , Loizou , L. , Davletov , B. and Brindle , K. M. 2001 . Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent . Nature Med. , 7 ( 11 ) : 1241
  • Wickline , S. A. , Neubauer , A. M. , Winter , P. M. , Caruthers , S. D. and Lanza , G. M. 2007 . Molecular imaging and therapy of atherosclerosis with targeted nanoparticles . J. Magn. Reson. Imaging , 25 ( 4 ) : 667
  • Jasanoff , A. 2005 . Functional MRI using molecular imaging agents . Trends Neurosci. , 28 ( 3 ) : 120
  • Winter , P. M. , Caruthers , S. D. , Wickline , S. A. and Lanza , G. M. 2006 . Molecular imaging by MRI . Curr. Cardiol. Rep. , 8 ( 1 ) : 65
  • Rogers , W. J. , Meyer , C. H. and Kramer , C. M. 2006 . Technology insight: In vivo cell tracking by use of MRI . Nat. Clin. Pract. Cardiovasc. Med. , 3 ( 10 ) : 554
  • Modo , M. , Hoehn , M. and Bulte , J. W. 2005 . Cellular MR imaging . Mol Imaging , 4 ( 3 ) : 143
  • Medarova , Z. , Pham , W. , Farrar , C. , Petkova , V. and Moore , A. 2007 . In vivo imaging of siRNA delivery and silencing in tumors . Nat. Med. ,
  • Wang , X. , Zhang , R. , Wu , C. , Dai , Y. , Song , M. , Gutmann , S. , Gao , F. , Lv , G. , Li , J. , Li , X. , Guan , Z. , Fu , D. and Chen , B. 2007 . The application of Fe(3)O(4) nanoparticles in cancer research: A new strategy to inhibit drug resistance . J. Biomed. Mater. Res. A , 80 ( 4 ) : 852
  • Plank , C. , Anton , M. , Rudolph , C. , Rosenecker , J. and Krotz , F. 2003 . Enhancing and targeting nucleic acid delivery by magnetic force . Expert Opin. Biol. Ther. , 3 ( 5 ) : 745
  • Dobson , J. 2006 . Magnetic nanoparticles for drug delivery . Drug Devel. Res. , 67 ( 1 ) : 55
  • Ito , A. , Kuga , Y. , Honda , H. , Kikkawa , H. , Horiuchi , A. , Watanabe , Y. and Kobayashi , T. 2004 . Magnetite nanoparticle-loaded Anti-Her2 immunoliposomes for combination of antibody therapy with hyperthermia . Cancer Lett. , 212 ( 2 ) : 167
  • Wust , P. , Gneveckow , U. , Johannsen , M. , Bohmer , D. , Henkel , T. , Kahmann , F. , Sehouli , J. , Felix , R. , Ricke , J. and Jordan , A. 2006 . Magnetic nanoparticles for interstitial thermotherapy—feasibility, tolerance and achieved temperatures . Int. J. Hyperthermia , 22 ( 8 ) : 673
  • Ito , A. , Fujioka , M. , Yoshida , T. , Wakamatsu , K. , Ito , S. , Yamashita , T. , Jimbow , K. and Honda , H. 2007 . 4-S-Cysteaminylphenol-loaded magnetite cationic liposomes for combination therapy of hyperthermia with chemotherapy against malignant melanoma . Cancer Sci. , 98 ( 3 ) : 424
  • Ivkov , R. , Denardo , S. J. , Daum , W. , Foreman , A. R. , Goldstein , R. C. , Nemkov , V. S. and Denardo , G. L. 2006 . Application of high amplitude alternating magnetic fields for heat induction of nanoparticies localized in cancer . Clin. Cancer Res. , 11 ( 19 ) : 7093S
  • Li , L. , Fan , M. H. , Brown , R. C. , Van Leeuwen , J. H. , Wang , J. J. , Wang , W. H. , Song , Y. H. and Zhang , P. Y. 2006 . Synthesis, properties, and environmental applications of nanoscale iron-based materials: A review . Critical Rev. Environmental Sci. Techn. , 36 ( 5 ) : 405
  • Mayo , J. T. , Yavuz , C. , Yean , S. , Cong , L. , Shipley , H. , Yu , W. , Falkner , J. , Kan , A. , Tomson , M. and Colvin , V. L. 2007 . Sci. Techn. Adv. Mater. , 8 ( 1–2 ) : 71

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