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Original Articles

Nanodiamond Particles: Properties and Perspectives for Bioapplications

, &
Pages 18-74 | Published online: 29 Apr 2009

REFERENCES

  • Shenderova , O. A. , Zhirnov , V. V. and Brenner , D. W. 2002 . Carbon nanostructures . Crit. Rev. Solid State Mater. Sci. , 27 : 227
  • Schwertfeger , H. , Fokin , A. A. and Schreiner , P. R. 2008 . Diamonds are a chemist's best friend: Diamondoid chemistry beyond adamantane . Angew. Chem. Int. Ed. Engl. , 47 : 1022
  • Da. Ros , T. P. 1999 . Medicinal chemistry with fullerenes and fullerene derivatives . Chem. Commun. (Camb.) , 663
  • Freitas , R. J. 2003 . Nanomedicine Volume IIA: Biocompatibility , Georgetown, TX : Landes Bioscience .
  • Bianco , A. 2004 . Carbon nanotubes for the delivery of therapeutic molecules . Expert. Opin. Drug. Deliv. , 1 : 57
  • Bianco , A. , Hoebeke , J. , Kostarelos , K. , Prato , M. and Partidos , C. D. 2005 . Carbon nanotubes: On the road to deliver . Curr. Drug. Deliv. , 2 : 253
  • Bianco , A. , Kostarelos , K. , Partidos , C. D. and Prato , M. 2005 . Biomedical applications of functionalised carbon nanotubes . Chem. Commun. (Camb.) , 571
  • Bianco , A. , Kostarelos , K. and Prato , M. 2005 . Applications of carbon nanotubes in drug delivery . Curr. Opin. Chem. Biol. , 9 : 674
  • Kam , N. W. and Dai , H. 2005 . Carbon nanotubes as intracellular protein transporters: Generality and biological functionality . J. Am. Chem. Soc. , 127 : 6021
  • Kam , N. W. , Liu , Z. and Dai , H. 2005 . Functionalization of carbon nanotubes via cleavable disulfide bonds for efficient intracellular delivery of siRNA and potent gene silencing . J. Am. Chem. Soc. , 127 : 12492
  • Kam , N. W. , O'connell , M. , Wisdom , J. A. and Dai , H. 2005 . Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction . Proc. Natl. Acad. Sci. USA , 102 : 11600
  • Kam , N. W. , Liu , Z. and Dai , H. 2006 . Carbon nanotubes as intracellular transporters for proteins and DNA: an investigation of the uptake mechanism and pathway . Angew. Chem. Int. Ed. Engl. , 45 : 577
  • Ali-Boucetta , H. , Al-Jamal , K. T. , Mccarthy , D. , Prato , M. , Bianco , A. and Kostarelos , K. 2008 . Multiwalled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics . Chem. Commun. (Camb.) , 459
  • Bianco , A. , Kostarelos , K. and Prato , M. 2008 . Opportunities and challenges of carbon-based nanomaterials for cancer therapy . Expert Opin. Drug. Deliv. , 5 : 331
  • Prato , M. , Kostarelos , K. and Bianco , A. 2008 . Functionalized carbon nanotubes in drug design and discovery . Acc. Chem. Res. , 41 : 60
  • Gonsalves , K. , Halberstadt , C. , Laurencin , C. T. and Nair , L. , eds. 2007 . Biomedical Nanostructures , Hoboken, NJ : Wiley-Interscience .
  • Labhasetwar , V. and Leslie-Pelecky , D. L. , eds. 2007 . Biomedical Applications of Nanotechnology , Hoboken, NJ : Wiley-VCH .
  • Salata , O. 2004 . Applications of nanoparticles in biology and medicine . J. Nanobiotechnology , 2 : 3
  • Urban , G. A. , ed. 2006 . BioMEMS , Dordrecht : Springer .
  • Castaneda , M. T. , Merkoci , A. , Pumera , M. and Alegret , S. 2007 . Electrochemical genosensors for biomedical applications based on gold nanoparticles . Biosens. Bioelectron. , 22 : 1961
  • Merkoci , A. 2007 . Electrochemical biosensing with nanoparticles . FEBS. J. , 274 : 310
  • Shoseyov , O. and Levy , I. , eds. 2008 . NanoBioTechnology: Bioinspired devices and materials of the future , Totowa, NJ : Humana Press .
  • Dubertret , B. , Skourides , P. , Norris , D. J. , Noireaux , V. , Brivanlou , A. H. and Libchaber , A. 2002 . In vivo imaging of quantum dots encapsulated in phospholipid micelles . Science , 298 : 1759
  • Saiyed , Z. , Telang , S. and Ramchand , C. 2003 . Application of magnetic techniques in the field of drug discovery and biomedicine . Biomagn. Res. Technol. , 1 : 2
  • Tartaj , P. 2003 . Probing nanomagnets' interactions inside colloidal superparamagnetic composites: aerosol versus surface template methods . Chemphyschem. , 4 : 1371
  • Tartaj , P. and Serna , C. J. 2003 . Synthesis of monodisperse superparamagnetic Fe/silica nanospherical composites . J. Am. Chem. Soc. , 125 : 15754
  • So , M. K. , Loening , A. M. , Gambhir , S. S. and Rao , J. 2006 . Creating self-illuminating quantum dot conjugates . Nat. Protoc. , 1 : 1160
  • So , M. K. , Xu , C. , Loening , A. M. , Gambhir , S. S. and Rao , J. 2006 . Self-illuminating quantum dot conjugates for in vivo imaging . Nat. Biotechnol. , 24 : 339
  • Brumfiel , G. 2003 . Nanotechnology: A little knowledge . Nature , 424 : 246
  • Brumfiel , G. 2003 . Hydrogen cars fuel debate on basic research . Nature , 422 : 104
  • Colvin , V. L. 2003 . The potential environmental impact of engineered nanomaterials . Nat. Biotechnol. , 21 : 1166
  • Hoet , P. H. , Nemmar , A. and Nemery , B. 2004 . Health impact of nanomaterials? . Nat. Biotechnol. , 22 : 19
  • Hoet , P. H. , Hohlfeld , Bruske-I. and Salata , O. V. 2004 . Nanoparticles - known and unknown health risks . J. Nanobiotechnology , 2 : 12
  • Proffitt , F. 2004 . Nanotechnology. Yellow light for nanotech . Science , 305 : 762
  • Service , R. F. 2004 . Nanotoxicology. Nanotechnology grows up . Science , 304 : 1732
  • Maynard , A. D. , Aitken , R. J. , Butz , T. , Colvin , V. , Donaldson , K. , Oberdorster , G. , Philbert , M. A. , Ryan , J. , Seaton , A. , Stone , V. , Tinkle , S. S. , Tran , L. , Walker , N. J. and Warheit , D. B. 2006 . Safe handling of nanotechnology . Nature , 444 : 267
  • Nel , A. , Xia , T. , Madler , L. and Li , N. 2006 . Toxic potential of materials at the nanolevel . Science , 311 : 622
  • Hurt , R. H. , Monthioux , M. and Kane , A. 2006 . Toxicology of carbon nanomaterials: Status, trends, and perspectives on the special issue . Carbon , 44
  • Riviere , J. E. , ed. 2006 . Biological concepts and techniques in toxicology: An integrated approach , New York : Taylor & Francis .
  • Shenderova , O. and Gruen , D. , eds. 2006 . Ultrananocrystalline Diamond , Norwich, NY : William-Andrew .
  • Chan , W. C. W. , ed. 2007 . Bio-applications of nanoparticles , Austin, TX : Landes Bioscience/Springer Science + Business Media .
  • Kumar , C. , ed. 2007 . Nanotechnologies for the life sciences Vol. 10: Nanomaterials for medical diagnosis and therapy” , New York : Wiley-VCH Verlag GmbH & Co. KgaA .
  • Monteiro-Riviere , N. A. and Tran , C. L. , eds. 2007 . Nanotoxicology: Characterization, dosing and health effects , New York : Informa Healthcare .
  • Mozafari , M. R. , ed. 2007 . Nanomaterials and nanosystems for biomedical applications , The Netherlands : Springer Publish Info Dordrecht .
  • Zhao , Y. and Nalwa , H. S. , eds. 2007 . Nanotoxicology: Interactions of nanomaterials with biological systems , Stevenson Ranch, CA : American Scientific .
  • Murdock , R. C. , Braydich-Stolle , L. , Schrand , A. M. , Schlager , J. J. and Hussain , S. M. 2008 . Characterization of nanomaterial dispersion in solution prior to in vitro exposure using dynamic light scattering technique . Toxicol. Sci. , 101 : 239
  • Schrand , A. M. , Johnson , J. , Dai , L. , Hussain , S. M. , Schlager , J. J. , Zhu , L. , Hong , Y. and Ôsawa , E. 2008 . “ Cytotoxicity and genotoxicity of carbon nanomaterials ” . In Safety of nanoparticles: from manufacturing to clinical applications , Edited by: Webster , T. Providence, RI : Springer Publishing, Brown University .
  • Gruen , D. M. 1999 . Nanocrystalline diamond films . Annu. Revi. Mater. Sci. , 29 : 211
  • Dolmatov , V. Y. 2001 . Detonation synthesis ultradispersed diamonds: Properties and applications . Russ. Chem. Rev. , 70 : 607
  • Baidakova , M. and Vul , A. 2007 . New prospects and frontiers of nanodiamond clusters . J. Physics D-Appl. Physics , 40 : 6300
  • Holt , K. B. 2007 . Diamond at the nanoscale: Applications of diamond nanoparticles from cellular biomarkers to quantum computing . Philos. Transact. A Math Phys. Eng. Sci. , 365 : 2845
  • Dolmatov , V. Y. 2007 . Detonation nanodiamonds: Synthesis, structure, properties and applications . USPEKHI KHIMII , 76 : 375
  • Krueger , A. 2008 . New carbon materials: Biological applications of functionalized nanodiamond materials . Chem. Eur. J. , 14 : 1382
  • Krueger , A. 2008 . Diamond nanoparticles: Jewels for chemistry and physics . Adv. Mater , 20 : 2445
  • Vereschagin , A. L. 2001 . Detonation nanodiamonds , Barnaul, Russian Federation : Altai State Technical University .
  • Danilenko , V. V. 2003 . Synthesis and sintering of diamond by detonation , Energoatomizdat .
  • Benedek , G. , Milani , P. and Ralchenko , V. G. 2001 . Nanostructured carbon for advanced applications , Edited by: Series , N. S. Vol. 24 , Dordrecht : Kluwer Academic Publishing .
  • Belobrov , P. I. . Nature of nanodiamond state and new applications of diamond nanotechnology . Proceedings of the IX International Conference: High-tech for Russian Industry . Moscow, Russia.
  • Vul , A. , Dolmatov , V. and Shenderova , O. 2003 . Detonation nanodiamonds and related materials, , First Edition ed. , St. Petersburg, Russia : FIZINTEL .
  • Gruen , D. M. , Shenderova , O. A. and Vul , A. Y. 2005 . Synthesis, properties, and applications of ultrananocrystallline diamond , Dordrecht, The Netherlands : Springer .
  • Advanced Diamond Technology , Romeoville, IL : I. W. T. C. .
  • Bajaj , P. , Akin , D. , Gupta , A. , Sherman , D. , Shi , B. , Auciello , O. and Bashir , R. 2007 . Ultrananocrystalline diamond film as an optimal cell interface for biomedical applications . Biomed. Microdevices , 9 : 787
  • Yang , W. S. , Auciello , O. , Butler , J. E. , Cai , W. , Carlisle , J. A. , Gerbi , J. , Gruen , D. M. , Knickerbocker , T. , Lasseter , T. L. , Russell , J. N. , Smith , L. M. and Hamers , R. J. 2002 . DNA-modified nanocrystalline diamond thin-films as stable, biologically active substrates . Nature Mater. , 1 : 253
  • www.microdiamant.com Microdiamant Ag, L., Switzerland
  • Danilenko , V. V. 2004 . On the history of the discovery of nanodiamond synthesis . Phys. Solid State , 46 : 595
  • Vereschagin , A. L. 2005 . Properties of detonation nanodiamonds , Altay Region : Barnaul State Technical University .
  • . The 3rd International Symposium Detonation Nanodiamonds: Technology, Properties and Applications . St. Petersburg, Russia.
  • Gogotsi , Y. , Welz , S. , Ersoy , D. A. and Mcnallan , M. J. 2001 . Conversion of silicon carbide to crystalline diamond-structured carbon at ambient pressure . Nature , 411 : 283
  • Daulton , T. L. , Kirk , M. A. , Lewis , R. S. and Rehn , L. E. 2001 . Production of nanodiamonds by high-energy ion irradiation of graphite at room temperature . Nucl. Instr. Meth. Phys. Res. S. B-Beam Inter. Mat. At. , 175 : 12
  • Banhart , F. and Ajayan , P. M. 1996 . Carbon onions as nanoscopic pressure cells for diamond formation . Nature , 382 : 433
  • Frenklach , M. , Howard , W. , Huang , D. , Yuan , J. , Spear , K. E. and Koba , R. 1991 . Induced nucleation of diamond powder . Appl. Phys. Lett. , 59 : 546
  • Tielens , A. , Seab , C. G. , Hollenbach , D. J. and Mckee , C. F. 1987 . Shock processing of interstellar dust—Diamonds in the sky . Astrophysical J. , 319 : L109
  • Daulton , T. L. 2006 . “ Extraterrestrial nanodiamonds in the cosmos ” . In Ultrananocrystalline diamond , Norwich, , UK : William-Andrew .
  • Rabeau , J. R. , Stacey , A. , Rabeau , A. , Prawer , S. , Jelezko , F. , Mirza , I. and Wrachtrup , J. 2007 . Single nitrogen vacancy centers in chemical vapor deposited diamond nanocrystals . Nano. Lett. , 7 : 3433
  • Yu , S. J. , Kang , M. W. , Chang , H. C. , Chen , K. M. and Yu , Y. C. 2005 . Bright fluorescent nanodiamonds: no photobleaching and low cytotoxicity . J. Am. Chem. Soc. , 127 : 17604
  • Fu , C. C. , Lee , H. Y. , Chen , K. , Lim , T. S. , Wu , H. Y. , Lin , P. K. , Wei , P. K. , Tsao , P. H. , Chang , H. C. and Fann , W. 2007 . Characterization and application of single fluorescent nanodiamonds as cellular biomarkers . Proc. Natl. Acad. Sci. USA , 104 : 727
  • Sonnefraud , Y. , Cuche , A. , Faklaris , O. , Boudou , J. P. , Sauvage , T. , Roch , J. F. , Treussart , F. and Huant , S. 2008 . Diamond nanocrystals hosting single nitrogen-vacancy color centers sorted by photon-correlation near-field microscopy . Opt. Lett. , 33 : 611
  • Decarli , P. S. and Jamieson , J. C. 1961 . Formation of diamond by explosive shock . Science , 133 : 1821
  • Danilenko , V. V. 2009 . Thermal stability of detonation nanodiamond depending on their quality . Super Hard Mat. , 31 ( 4 ) in press
  • Huang , H. , Pierstorff , E. , Osawa , E. and Ho , D. 2007 . Active nanodiamond hydrogels for chemotherapeutic delivery . Nano. Lett. , 7 : 3305
  • Bondar , V. S. , Pozdnyakova , I. O. and Puzyr , A. P. 2004 . Applications of nanodiamonds for separation and purification of proteins . Phy. Solid State , 46 : 758
  • Huang , L. C. and Chang , H. C. 2004 . Adsorption and immobilization of Cytochrome c on nanodiamonds . Langmuir , 20 : 5879
  • Kong , X. L. , Huang , L. C. , Hsu , C. M. , Chen , W. H. , Han , C. C. and Chang , H. C. 2005 . High-affinity capture of proteins by diamond nanoparticles for mass spectrometric analysis . Anal. Chem. , 77 : 259
  • Kong , X. , Huang , L. C. , Liau , S. C. , Han , C. C. and Chang , H. C. 2005 . Polylysine-coated diamond nanocrystals for MALDI-TOF mass analysis of DNA oligonucleotides . Anal. Chem. , 77 : 4273
  • Grichko , V. , Grishko , V. and Shenderova , O. 2007 . Nanodiamond bullets and their biological targets . Nanobiotechnology , 2 : 37
  • Gibson , N. , Shenderova , O. , Puzyr , A. , Purtov , K. , Grichko , V. , Luo , T. J. M. , Fitgerald , Z. , Bondar , V. and Brenner , D. . Nanodiamonds for detoxification . Technical Proceedings of the 2007 NSTI NanoTechnology Conference and Trade Show .
  • Puzyr , A. P. , Purtov , K. V. , Shenderova , O. A. , Luo , M. , Brenner , D. W. and Bondar , V. S. 2007 . The adsorption of aflatoxin B1 by detonation-synthesis nanodiamonds . Dokl. Biochem. Biophys , 417 : 299
  • Dahl , J. E. , Liu , S. G. and Carlson , R. M. K. 2003 . Isolation and structure of higher diamondoids, nanometer-sized diamond molecules . Science , 299 : 96
  • Carlson , R. M. K. , Dahl , J. E. P. and Liu , S. G. 2005 . “ Diamond molecules found in petroleum ” . In Synthesis, properties, and applications of ultrananocrystallline diamond , Edited by: Gruen , D. M. , Vul , A. and Shenderova , O. A. Dordrecht, The Netherlands : Springer .
  • Freitas , R. A. 2003 . Biocompatibility, Nanomedicine, Vol. IIA , Austin, TX : Landes Bioscience .
  • Grichko , V. and Shenderova , O. 2006 . “ Nanodiamond designing the bioplatform ” . In Ultrananocrystalline diamond: Synthesis, properties, and applications , Edited by: Shenderova , O. and Gruen , D. 529 – 557 . Norwich, , UK : William-Andrew .
  • Dolmatov , V. . Third International Symposium Detonation Nanodiamonds: Technology, Properties and Applications . St. Petersburg, Russia.
  • Gubarevich , T. . Third International Symposium Detonation Nanodiamonds: Technology, Properties and Applications . St. Petersburg, Russia.
  • Larionova , I. , Kuznetsov , V. , Frolov , A. , Shenderova , O. , Moseenkov , S. and Mazov , I. 2006 . Properties of individual fractions of detonation nanodiamond . Diamond Relat. Mater. , 15 : 1804
  • Krueger , A. and Boedeker , T. 2008 . Deagglomeration and functionalization of detonation nanodiamonds . Diamond Relat. Mater. , 17 : 1367
  • Neugart , F. , Zappe , A. , Jelezko , F. , Tietz , C. , Boudou , J. P. , Krueger , A. and Wrachtrup , J. 2007 . Dynamics of diamond nanoparticles in solution and cells . Nano Lett. , 7 : 2588
  • Krueger , A. , Stegk , J. , Liang , Y. , Lu , L. and Jarre , G. 2008 . Biotinylated nanodiamond: Simple and efficient functionalization of detonation diamond . Langmuir , 24 : 4200
  • Danilenko , V. V. 2004 . Shock-wave sintering of nanodiamonds . Phys. Solid State , 46 : 711
  • Viecelli , J. A. and Ree , F. H. 2000 . Carbon particle phase transformation kinetics in detonation waves . J. Appl. Phys. , 88 : 683
  • Titov , V. M. , Tolochko , B. P. , Ten , K. A. , Lukyanchikov , L. A. and Pruuel , E. R. 2007 . Where and when are nanodiamonds formed under explosion? . Diamond Relat. Mater. , 16 : 2009
  • Danilenko , V. V. 2006 . Peculiarities of carbon condensation in a detonation wave and conditions of nanodiamonds optimal synthesis . Superhard Mater. , N5 : 9
  • Raty , J. Y. , Galli , G. , Bostedt , C. , Van Buuren , T. W. and Terminello , L. J. 2003 . Quantum confinement and fullerenelike surface reconstructions in nanodiamonds . Phys. Rev. Lett. , 90 : 037401
  • Osswald , S. , Yushin , G. , Mochalin , V. , Kucheyev , S. O. and Gogotsi , Y. 2006 . Control of sp2/sp3 carbon ratio and surface chemistry of nanodiamond powders by selective oxidation in air . J. Am. Chem. Soc. , 128 : 11635
  • Pichot , V. , Comet , M. , Fousson , E. , Baras , C. , Senger , A. , Le Normand , F. and Spitzer , D. 2008 . An efficient purification method for detonation nanodiamonds . Diamond Relat. Mater. , 17 : 13
  • Petrov , I. and Shenderova , O. 2006 . “ History of Russian patents on detonation nanodiamonds ” . In Ultrananocrystalline diamond , Edited by: Shenderova , O. and Gruen , D. Norwich, , UK : William-Andrew .
  • Petrov , I. , Shenderova , O. , Grishko , V. , Grichko , V. , Tyler , T. , Cunningham , G. and Mcguire , G. 2007 . Detonation nanodiamonds simultaneously purified and modified by gas treatment . Diamond Relat. Mater. , 16 : 2098
  • Chiganov , A. S. 2004 . Selective inhibition of the oxidation of nanodiamonds for their cleaning . Phys. Solid State , 46 : 620
  • Dolmatov , V. Y. , Veretennikova , M. V. , Marchukov , V. A. and Sushchev , V. G. 2004 . Currently available methods of industrial nanodiamond synthesis . Phys. Solid State , 46 : 611
  • Larionova , I. S. , Molostov , I. N. , Kulagina , L. S. and Komarov , V. F. Method of purification of synthetic ultradispersed diamonds . RU Patent 2168462 . 1999 .
  • Pavlov , E. V. and Skrjabin , J. A. Method for removal of impurities of non-diamond carbon and device for its realization . RU Patent 2019502 . 1994 .
  • Mitev , D. , Dimitrova , R. , Spassova , M. , Minchev , C. and Stavrev , S. 2007 . Surface peculiarities of detonation nanodiamonds in dependence of fabrication and purification methods . Diamond Relat. Mater. , 16 : 776
  • Shenderova , O. , Petrov , I. , Walsh , J. , Grichko , V. , Grishko , V. , Tyler , T. and Cunningham , G. 2006 . Modification of detonation nanodiamonds by heat treatment in air . Diamond Relat. Mater. , 15 : 1799
  • Mochalin , V. and Gogotsi , Y. 2009 . Wet chemistry route to hydrophobic blue fluorescent nanodiamond . J. Am. Chem. Soc. , 131 ( 13 ) : 4594
  • Timofeev , V. T. and Detkov , P. Y. 2005 . Diamonds from explosive materials . Atom , 4 : 1
  • Krueger , A. , Kataoka , F. , Ozawa , M. , Fujino , T. , Suzuki , Y. , Aleksenskii , A. E. , Vul , A. Y. and Osawa , E. 2005 . Unusually tight aggregation in detonation nanodiamond: Identification and disintegration . Carbon , 43 : 1722
  • Larinova , I. , Petrov , I. and Shenderova , O. Zeta potential of detonation nanodiamonds depending on method of purification in preparation
  • Gordeev , S. K. and Kruglikova , S. Method of processing of powders of nanodiamond for obtaining stable suspensions . RU Patent Application 2004121069 . 2004 .
  • Xu , X. Y. , Yu , Z. M. , Zhu , Y. W. and Wang , B. C. 2005 . Influence of surface modification adopting thermal treatments on dispersion of detonation nanodiamond . J. Solid State Chem. , 178 : 688
  • Spitsyn , B. , Davidson , J. , Gradoboev , M. , Galushko , T. , Serebryakova , N. , Karpukhina , T. , Kulakova , I. and Melnik , M. 2006 . Inroad to modification of detonation nanodiamond . Diamond Relat. Mater. , 15 : 296
  • Chukhaeva , S. I. , Detkov , P. , Tkachenko , A. and Toropov , A. 1998 . Physicochemical properties of fractions isolated from ultradispersed diamonds . SVERKHTVERD MAT , 4 : 29
  • Chukhaeva , S. I. 2004 . Synthesis, properties, and applications of fractionated nanodiamonds . Phys. Solid State , 46 : 625
  • Grichko , V. , Tyler , T. , Grishko , V. I. and Shenderova , O. 2008 . Nanodiamond particles forming photonic structures . Nanotechnology , 19 : 225201
  • Iakoubovskii , K. , Mitsuishi , K. and Furuya , K. 2008 . High-resolution electron microscopy of detonation nanodiamond . Nanotechnology , 19 : 155705
  • Krueger , A. , Ozawa , M. , Jarre , G. , Liang , Y. , Stegk , J. and Lu , L. 2007 . Deagglomeration and functionalisation of detonation diamond . Physica Status Solidi a-Appli. Mater. Sci. , 204 : 2881
  • Zhu , Y. W. , Xu , F. , Shen , J. L. , Wang , B. C. , Xu , X. Y. and Shao , J. B. 2007 . Study on the modification of nanodiamond with DN-10 . J. Mater. Sci. Technol. , 23 : 599
  • Morita , Y. , Takimoto , T. , Yamanaka , H. , Kumekawa , K. , Morino , S. , Aonuma , S. , Kimura , T. and Komatsu , N. 2008 . A Facile and scalable process for size-controllable separation of nanodiamond particles as small as 4 nm . Small , 4 : 2154
  • Ozawa , M. , Inaguma , M. , Takahashi , M. , Kataoka , F. , Kruger , A. and Osawa , E. 2007 . Preparation and behavior of brownish, clear nanodiamond colloids . Adv. Mater. , 19 : 1201
  • Ozerin , A. , Kurkin , T. S. , Ozerina , L. A. and Dolmatov , V. Y. 2008 . X-ray diffraction study of the structure of detonation nanodiamonds . Crystallogr. Repo. , 53 : 60
  • Osawa , E. 2007 . Recent progress and perspectives in single-digit nanodiamond . Diamond Relat. Mater. , 16 : 2018
  • Huang , H. J. , Dai , L. M. , Wang , D. H. , Tan , L. S. and Osawa , E. 2008 . Large-scale self-assembly of dispersed nanodiamonds . J. Mater. Chem. , 18 : 1347
  • Xu , K. and Xue , Q. J. 2007 . Deaggregation of ultradispersed diamond from explosive detonation by a graphitization-oxidation method and by hydroiodic acid treatment . Diamond Relat. Mater. , 16 : 277
  • Gibson , N. , Shenderova , O. , Luo , T. J. M. , Moseenkov , S. , Bondar , V. , Puzyr , A. , Purtov , K. , Fitzgerald , Z. and Brenner , D. 2009 . Colloidal stability of modified nanodiamond particles . Diamond Relat. Mater. , 18 : 620
  • Hens , S. , Wallen , S. , Shenderova , O. and Patent , U. S. 2007 . Application: Nanodiamond fractionation and products thereof
  • Bondar , V. S. and Puzyr , A. P. 2004 . Nanodiamonds for biological investigations . Phys. Solid State , 46 : 716
  • Puzyr , A. P. and Bondar , V. S. Method of production of nanodiamonds of explosive synthesis with an increased colloidal stability . RU Patent 2252192 . 2003 .
  • Tsubota , T. , Tanii , S. , Ida , S. , Nagata , M. and Matsumoto , Y. 2004 . Chemical modification of diamond surface with various carboxylic acids by radical reaction in liquid phase . Diamond Relat. Mater. , 13 : 1093
  • Tsubota , T. , Ohno , T. , Yoshida , H. and Kusakabe , K. 2006 . Introduction of molecules containing a NO2 group on diamond surface by using radical reaction in liquid phase . Diamond Relat. Mater. , 15 : 668
  • Ida , S. , Tsubota , T. , Tanii , S. , Nagata , M. and Matsumoto , Y. 2003 . Chemical modification of the diamond surface using benzoyl peroxide and dicarboxylic acids . Langmuir , 19 : 9693
  • Liu , Y. , Gu , Z. N. , Margrave , J. L. and Khabashesku , V. N. 2004 . Functionalization of nanoscale diamond powder: Fluoro-, alkyl-, amino-, and amino acid-nanodiamond derivatives . Chem. Mater. , 16 : 3924
  • Loktev , V. F. , Makalskii , V. I. and Stoyanova , I. V. 1991 . Surface modification of ultradispersed diamonds . Carbon , 29 : 817
  • Remes , Z. , Kromka , A. , Vanecek , M. , Grinevich , A. , Hartmannova , H. and Kmoch , S. 2007 . The RF plasma surface chemical modification of nanodiamond films grown on glass and silicon at low temperature . Diamond Relat. Mater. , 16 : 671
  • Ray , M. A. , Tyler , T. , Hook , B. , Martin , A. , Cunningham , G. , Shenderova , O. , Davidson , J. L. , Howell , M. , Kang , W. P. and Mcguire , G. 2007 . Cool plasma functionalization of nano-crystalline diamond films . Diamond Relat. Mater. , 16 : 2087
  • Lisichkin Korolkov , G. V. , Tarasevich Kulakova , B. I. and Karpukhin , A. 2006 . Photochemical chlorination of nanodiamond and interaction of its modified surface with C-nucleophiles . Russ. Chem. Bull. , 55 : 2212
  • 2004 . Kulakova, Ii, Surface chemistry of nanodiamonds . Phys. Solid State , 46 : 636
  • Krueger , A. , Liang , Y. J. , Jarre , G. and Stegk , J. 2006 . Surface functionalisation of detonation diamond suitable for biological applications . Journal of Materials Chemistry , 16 : 2322
  • Hens , S. C. , Cunningham , G. , Tyler , T. , Moseenkov , S. , Kuznetsov , V. and Shenderova , O. 2008 . Nanodiamond bioconjugate probes and their collection by electrophoresis . Diamond Relat. Mater. , 17 : 1858
  • Li , L. , Van Der Ende , A. E. , Davidson , J. L. and Lukehart , C. M. 2006 . Nanodiamond/polymer brushes: Synthesis, characterization and application . Abstr. Papers Am. Chem. Soc. , : 231
  • Krueger , A. 2008 . The structure and reactivity of nanoscale diamond . J. Mater. Chem. , 18 : 1485
  • Ji , S. , Jiang , T. , Xu , K. and Li , S. 1998 . FTIR study of the adsorption of water on ultradispersed diamond powder surface . Appl. Surface Sci. , 133 : 231
  • Jiang , T. and Xu , K. 1995 . FTIR study of ultradispersed diamond powder synthesized by explosive detonation . Carbon , 33 : 1663
  • Jiang , T. , Xu , K. and Ji , S. 1996 . FTIR studies on the specrtral changes of the surface functional groups of ultradispersed diamond powder synthesized by explosive detonation after treatment in hydrogen, nitrogen, methane and air at different temperatures . Faraday Trans. , 92 : 3401
  • Kuo , T. C. , McCreery , R. L. and Swain , G. M. 1999 . Electrochemical modification of boron-doped chemical vapor deposited diamond surfaces with covalently bonded monolayers . Electrochem. Solid State Lett. , 2 : 288
  • Aleksenskii , A. E. , Osipov , V. Y. , Vul , A. Y. , Ber , B. Y. , Smirnov , A. B. , Melekhin , V. G. , Adriaenssens , G. J. and Lakoubovskii , K. 2001 . Optical properties of nanodiamond layers . Phys. Solid State , 43 : 145
  • Komatsu , N. , Kadota , N. , Kimura , T. and Osawa , E. 2007 . Solution-phase C-13 NMR spectroscopy of detonation nanodiamond . Chem. Lett. , 36 : 398
  • Chiganova , G. A. 2000 . Aggregation of particles in ultradispersed diamond hydrosols . Colloid J. , 62 : 238
  • Xua , X. , Yu , Z. , Zhu , Y. and Wang , B. 2005 . Effect of sodium oleate adsorption on the colloidal stability and zeta potential of detonation synthesized diamond particles in aqueous solutions . Diamond Relat. Mater. , 14 : 206
  • Boehm , H. P. 2002 . Surface oxides on carbon and their analysis: a critical assessment . Carbon , 40 : 145
  • Fuente , E. , Menendez , J. A. , Suarez , D. and Moran , Montes-M. A. 2003 . Basic surface oxides on carbon materials: A global view . Langmuir , 19 : 3505
  • Donnet , J. B. , Boehm , H. P. and Stoeckli , F. 2002 . Third International Conference on Carbon Black Mulhouse (October 2000) - Preface . Carbon , 40 : 145
  • Montes-Moran , M. A. , Suarez , D. , Menendez , J. A. and Fuente , E. 2004 . On the nature of basic sites on carbon surfaces: An overview . Carbon , 42 : 1219
  • Shenderova , O. , Grichko , V. , Hens , S. and Walsh , J. 2007 . Detonation nanodiamonds as UV radiation filter . Diamond Relat. Mater. , 16 : 2003
  • Aleksenskii , A. E. , Baidakova , M. V. , Vul , A. Y. and Siklitskii , V. I. 1999 . The structure of diamond nanoclusters . Phys. Solid State , 41 : 668
  • Sque , S. , Jones , R. and Briddon , P. 2006 . Structure, electronics, and interaction of hydrogen and oxygen on diamond surfaces . Phys. Rev. B , 73 : 85313
  • Kern , G. and Hafner , J. 1997 . Ab initio calculations of the atomic and electronic structure of clean and hydrogenated diamond (110) surfaces . Phys. Rev.B , 56 : 4203
  • Borjanovic , V. , Lawrence , W. G. , Hens , S. , Jaksic , M. , Zamboni , I. , Edson , C. , Vlasov , V. , Shenderova , O. and Mcguire , G. 2008 . Effect of proton irradiation on photoluminescent properties of PDMS nanodiamond composites . Nanotechnology , 19 : 455701
  • Kvit , A. V. , Zhirnov , V. V. , Tyler , T. and Hren , J. J. 2004 . Aging effect and nitrogen distribution in diamond nanoparticles . Composites Part B-Engin. , 35 : 163
  • Chang , Y. R. , Lee , H. Y. , Chen , K. , Chang , C. C. , Tsai , D. S. , Fu , C. C. , Lim , T. S. , Tzeng , Y. K. , Fang , C. Y. , Han , C. C. , Chang , H. C. and Fann , W. 2008 . Mass production and dynamic imaging of fluorescent nanodiamonds . Nat. Nanotechnol. , 3 : 284
  • Schrand , A. M. , Huang , H. , Carlson , C. , Schlager , J. J. , Omacr , E. Sawa , Hussain , S. M. and Dai , L. 2007 . Are diamond nanoparticles cytotoxic? . J. Phys. Chem. B , 111 : 2
  • Dolmatov , V. Y. 2006 . “ Application of detonation nanodiamond ” . In Ultra nanocrystalline diamond: synthesis, properties, and applications , Edited by: Shenderova , O. and Gruen , D. 513 Norwich, NY, , USA : William Andrew Publishing .
  • Puzyr , A. P. , Baron , A. V. , Purtov , K. V. , Bortnikov , E. V. , Skobelev , N. N. , Moginaya , O. A. and Bondar , V. S. 2007 . Nanodiamonds with novel properties: A biological study . Diamond Relat. Mater. , 16 : 2124
  • Skebo , J. E. , Grabinski , C. M. , Schrand , A. M. , Schlager , J. J. and Hussain , S. M. 2007 . Assessment of metal nanoparticle agglomeration, uptake, and interaction using high-illuminating system . In.t J. Toxicol. , 26 : 135
  • Treussart , F. , Jacques , V. , Wu , E. , Gacoln , T. , Grangier , P. and Roch , J. F. 2006 . Photoluminescence of single colour defects in 50 nm diamond nanocrystals . Physica B-Condensed Matter , 376 : 926
  • Faklaris , O. , Sonnefraud , Y. , Cuche , A. , Sauvage , T. , Joshi , V. , Boudou , J. P. , Curmi , P. A. , Roch , J. F. , Huant , S. and Treussart , F. 2007 . Diamond nanoparticles as photoluminescent nanoprobes . Annales De Physique , 32 : 155
  • Cheng , C. Y. , Perevedentseva , E. , Tu , J. S. , Chung , P. H. , Cheng , C. L. , Liu , K. K. , Chao , J. I. , Chen , P. H. and Chang , C. C. 2007 . Direct and in vitro observation of growth hormone receptor molecules in A549 human lung epithelial cells by nanodiamond labeling . Appl. Phys. Lett. , 90 : 163903
  • Perevedentseva , E. , Cheng , C. Y. , Chung , P. H. , Tu , J. S. , Hsieh , Y. H. and Cheng , C. L. 2007 . The interaction of the protein lysozyme with bacteria E. coli observed using nanodiamond labelling . Nanotechnology , 18 : 315102
  • Lim , Y. T. , Kim , S. , Nakayama , A. , Stott , N. E. , Bawendi , M. G. and Frangioni , J. V. 2003 . Selection of quantum dot wavelengths for biomedical assays and imaging . Mol. Imaging , 2 : 50
  • Gaebel , T. , Popa , I. , Gruber , A. , Domhan , M. , Jelezko , F. and Wrachtrup , J. 2004 . Stable single-photon source in the near infrared . New J. Phys. , : 6
  • Zaitsev , A. M. 2000 . Vibronic spectra of impurity-related optical centers in diamond . Phys. Rev. B , 61 : 12909
  • Jelezko , F. and Wrachtrup , J. 2006 . Single defect centres in diamond: A review . Physica Status Solidi a-Appl. Mater. Sci. , 203 : 3207
  • Gruber , A. , Drabenstedt , A. , Tietz , C. , Fleury , L. , Wrachtrup , J. and Vonborczyskowski , C. 1997 . Scanning confocal optical microscopy and magnetic resonance on single defect centers . Science , 276 : 2012
  • Kompan , M. E. , Terukov , E. I. , Gordeev , S. K. , Zhukov , S. G. and Nikolaev , Y. A. 1997 . Photoluminescence spectra of ultradisperse diamond . Phys. Solid State , 39 : 1928
  • Aleksenskii , A. E. , Osipov , V. Y. , Kryukov , N. A. , Adamchuk , V. K. , Abaev , M. I. , Vul , S. P. and Vul , A. Y. 1997 . Optical properties of layers of ultradisperse diamond obtained from an aqueous suspension . Tech. Phys. Lett. , 23 : 874
  • Gorelik , V. S. and Rakhmatullaev , I. A. 2004 . Photoluminescence of diamond films and ultrafine diamond under UV laser excitation . Inorganic Mater. , 40 : 686
  • Zhao , F. L. , Gong , Z. , Liang , S. D. , Xu , N. S. , Deng , S. Z. , Chen , J. and Wang , H. Z. 2004 . Ultrafast optical emission of nanodiamond induced by laser excitation . Appl. Phys. Lett. , 85 : 914
  • Dumeige , Y. , Treussart , F. , Alleaume , R. , Gacoin , T. , Roch , J. F. and Grangier , P. 2004 . Photo-induced creation of nitrogen-related color centers in diamond nanocrystals under femtosecond illumination . J. Luminescence , 109 : 61
  • Glinka , Y. D. , Lin , K. W. , Chang , H. C. and Lin , S. H. 1999 . Multiphoton-excited luminescence from diamond nanoparticles . J. Phys. Chem. B , 103 : 4251
  • Chao , J. I. , Perevedentseva , E. , Chung , P. H. , Liu , K. K. , Cheng , C. Y. , Chang , C. C. and Cheng , C. L. 2007 . Nanometer-sized diamond particle as a probe for biolabeling . Biophys. J. , 93 : 2199
  • Liu , K. K. , Cheng , C. L. , Chang , C. C. and Chao , J. I. 2007 . Biocompatible and detectable carboxylated nanodiamond on human cell . Nanotechnology , : 18
  • Chung , P. H. , Perevedentseva , E. and Cheng , C. L. 2007 . The particle size-dependent photoluminescence of nanodiamonds . Surface Sci. , 601 : 3866
  • Wee , T. L. , Tzeng , Y. K. , Han , C. C. , Chang , H. C. , Fann , W. , Hsu , J. H. , Chen , K. M. and Yull , Y. C. 2007 . Two-photon excited fluorescence of nitrogen-vacancy centers in proton-irradiated type Ib diamond . J. Phys. Chem. A , 111 : 9379
  • Martin , J. , Wannemacher , R. , Teichert , J. , Bischoff , L. and Kohler , B. 1999 . Generation and detection of fluorescent color centers in diamond with submicron resolution . Appl. Phys. Lett. , 75 : 3096
  • Wang , C. L. , Kurtsiefer , C. and Weinfurter , H. 2006 . Single photon emission from SiV centres in diamond produced by ion implantation . J. Phys. B-Atom. molec. opti. phys. , 39 : 37
  • Schrand , A. M. 2007 . “ Characterization and in vitro biocompatibility of engineered nanomaterials ” . In The School of Engineering , 276 Dayton, OH : University of Dayton .
  • Schrand , A. M. , Braydich-Stolle , L. K. , Schlager , J. J. , Hussain , S. M. and Dai , L. 2009 . Intracellular destination of fluorophore-conjugated nanodiamonds (in preparation)
  • Hens , S. C. , Cunningham , G. , Grichko , V. , Tyler , T. , Moseenkov , S. , Kuznetsov , V. and Shenderova , G. M. O. . Biological uses for chemically derivatized detonation nanodiamonds . Third International Symposium Detonation Nanodiamonds: Technology, Properties and Applications . St. Petersburg, Russia.
  • Colpin , Y. , Swan , A. , Zvyagin , A. V. and Plakhotnik , T. 2006 . Imaging and sizing of diamond nanoparticles . Optics Lett. , 31 : 625
  • Smith , B. R. , Niebert , M. , Plakhotnik , T. and Zvyagin , A. V. 2007 . Transfection and imaging of diamond nanocrystals as scattering optical labels . J. Luminescence , 127 : 260
  • Perevedentseva , E. , Karmenyan , A. , Chung , P. H. , He , Y. T. and Cheng , C. L. 2006 . Surface enhanced Raman spectroscopy of carbon nanostructures . Surface Sci. , 600 : 3723
  • Wu , V. W. K. 2006 . Adsorption reaction constants between nanosilica/nanodiamond and lysozyme molecule at pH = 11.0 . Chem. Lett. , 35 : 1380
  • Yeap , W. S. , Tan , Y. Y. and Loh , K. P. 2008 . Using detonation nanodiamond for the specific capture of glycoproteins . Anal. Chem. ,
  • Purtov , K. V. , Puzyr , A. P. and Bondar , V. S. 2008 . Nanodiamond sorbents: new carriers for column chromatography of proteins . Dokl. Biochem. Biophys. , 419 : 72
  • Fedyanina , O. N. and Nesterenko , P. N. . Investigation of the properties of sintered nanodiamonds as stationary phase for HPLC . Third International Symposium Detonation Nanodiamonds: Technology, Properties and Applications . St. Petersburg, Russia.
  • Railkar , T. A. , Kang , W. P. , Windischmann , H. , Malshe , A. P. , Naseem , H. A. , Davidson , J. L. and Brown , W. D. 2000 . A critical review of chemical vapor-deposited (CVD) diamond for electronic applications . Crit. Revi. Solid State Mater. Sci. , 25 : 163
  • Fortin , E. , Tune , Chane-J. , Delabouglise , D. , Bouvier , P. , Livache , T. , Mailley , P. , Marcus , B. , Mermoux , M. , Petit , J. P. , Szunerits , S. and Vieil , E. 2005 . Interfacing boron doped diamond and biology: An insight on its use for bioanalytical applications . Electroanalysis , 17 : 517
  • Bakowicz-Mitura , K. , Bartosz , G. and Mitura , S. 2007 . Influence of diamond powder particles on human gene expression . Surface Coatings Technol. , 201 : 6131
  • Puzyr , A. P. , Pozdnyakova , I. O. and Bondar , V. S. 2004 . Design of a luminescent biochip with nanodiamonds and bacterial luciferase . Phys. Solid State , 46 : 761
  • Kloss , F. R. , Najam-Ul-Haq , M. , Rainer , M. , Gassner , R. , Lepperdinger , G. , Huck , C. W. , Bonn , G. , Klauser , F. , Liu , X. , Memmel , N. , Bertel , E. , Garrido , J. A. and Steinmuller-Nethl , D. 2007 . Nanocrystalline diamond—an excellent platform for life science applications . J. Nanosci. Nanotechnol. , 7 : 4581
  • Kalbacova , M. , Kalbac , M. , Dunsch , L. , Kromka , A. , Vanecek , M. , Rezek , B. , Hempel , U. and Kmoch , S. 2007 . The effect of SWCNT and nano-diamond films on human osteoblast cells . Physica Status Solidi B-Basic Solid State Phys. , 244 : 4356
  • Hughes , M. P. 2000 . AC electrokinetics: Applications for nanotechnology . Nanotechnology , 11 : 124
  • Zhitomirsky , I. 2002 . Cathodic electrodeposition of ceramic and organoceramic materials. Fundamental aspects . Adv. Colloid Interface Sci. , 97 : 279
  • Alimova , A. N. , Chubun , N. N. , Belobrov , P. I. , Detkov , P. Y. and Zhirnov , V. V. 1999 . Electrophoresis of nanodiamond powder for cold cathode fabrication . J. Vacuum Sci. Technol. B , 17 : 715
  • Zhitomirsky , I. 1998 . Cathodic electrophoretic deposition of diamond particles . Mater. Lett. , 37 : 72
  • Daenen , M. , Williams , O. A. , D'haen , J. , Haenen , K. and Nesladek , M. 2006 . Seeding, growth and characterization of nanocrystalline diamond films on various substrates . Physica Status Solidi a-Appli. Mater. Scie. , 203 : 3005
  • Williams , O. A. , Douheret , O. , Daenen , M. , Haenen , K. , Osawa , E. and Takahashi , M. 2007 . Enhanced diamond nucleation on monodispersed nanocrystalline diamond . Chem. Phys. Lett. , 445 : 255
  • Affoune , A. M. , Prasad , B. L. V. , Sato , H. and Enoki , T. 2001 . Electrophoretic deposition of nanosized diamond particles . Langmuir , 17 : 547
  • Riveros , L. L. , Tryk , D. A. and Cabrera , C. R. 2005 . Chemical purification and characterization of diamond nanoparticles for electrophoretically coated electrodes . Rev. Adv. Mater. Sci. , 10 : 256
  • Kraft , A. 2007 . Doped diamond: A compact review on a new, versatile electrode material . Int. J. Electrochem. Sci. , 2 : 355
  • McCreery , R. L. 2008 . Advanced carbon electrode materials for molecular electrochemistry . Chem. Rev. , 108 : 2646
  • Halpern , J. M. , Xie , S. T. , Sutton , G. P. , Higashikubo , B. T. , Chestek , C. A. , Lu , H. , Chiel , H. J. and Martin , H. B. 2006 . Diamond electrodes for neurodynamic studies in Aplysia californica . Diamond Relat. Mater. , 15 : 183
  • Nebel , C. E. , Rezek , B. , Shin , D. , Uetsuka , H. and Yang , N. 2007 . Diamond for bio-sensor applications . J. Phys. D-Appl. Phys. , 40 : 6443
  • Vermeeren , V. , Bijnens , N. , Wenmackers , S. , Daenen , M. , Haenen , K. , Williams , O. A. , Ameloot , M. , Vandeven , A. , Wagner , P. and Michiels , L. 2007 . Towards a real-time, label-free, diamond-based DNA sensor . Langmuir , 23 : 13193
  • Zhao , W. , Xu , J. J. , Qiu , Q. Q. and Chen , H. Y. 2006 . Nanocrystalline diamond modified gold electrode for glucose biosensing . Biosens. Bioelectr. , 22 : 649
  • Holt , K. B. , Ziegler , C. , Caruana , D. J. , Zang , J. , Barrios , Millan-E. J. , Hu , J. and Foord , J. S. 2008 . Redox properties of undoped 5 nm diamond nanoparticles . Phys. Chem. Chem. Phys. , 10 : 303
  • Novoselova , I. A. , Fedoryshena , E. N. , Panov , E. V. , Bochechka , A. A. and Romanko , L. A. 2004 . Electrochemical properties of compacts of nano- and microdisperse diamond powders in aqueous electrolytes . Phys. Solid State , 46 : 748
  • Zang , J. B. , Wang , Y. H. , Zhao , S. Z. , Bian , L. Y. and Lu , J. 2007 . Electrochemical properties of nanodiamond powder electrodes . Diamond Relat. Mater. , 16 : 16
  • Napier , M. E. and Thorp , H. H. 1999 . Electrocatalytic oxidation of nucleic acids at electrodes modified with nylon and nitrocellulose membranes . J. Fluorescence , 9 : 181
  • Oberdorster , G. , Finkelstein , J. N. , Johnston , C. , Gelein , R. , Cox , C. , Baggs , R. and Elder , A. C. 2000 . Acute pulmonary effects of ultrafine particles in rats and mice . Res. Rep. Health Eff. Inst. , : 5
  • Donaldson , K. , Brown , D. , Clouter , A. , Duffin , R. , Macnee , W. , Renwick , L. , Tran , L. and Stone , V. 2002 . The pulmonary toxicology of ultrafine particles . J. Aerosol. Med. , 15 : 213
  • Braydich-Stolle , L. , Hussain , S. , Schlager , J. J. and Hofmann , M. C. 2005 . In vitro cytotoxicity of nanoparticles in mammalian germline stem cells . Toxicol. Sci. , 88 : 412
  • Hussain , S. M. , Hess , K. L. , Gearhart , J. M. , Geiss , K. T. and Schlager , J. J. 2005 . In vitro toxicity of nanoparticles in BRL 3A rat liver cells . Toxicol. In Vitro , 19 : 975
  • Donaldson , K. , Stone , V. , Tran , C. L. , Kreyling , W. and Borm , P. J. 2004 . Nanotoxicology . Occup. Environ. Med. , 61 : 727
  • Foley , S. , Crowley , C. , Smaihi , M. , Bonfils , C. , Erlanger , B. F. , Seta , P. and Larroque , C. 2002 . Cellular localisation of a water-soluble fullerene derivative . Biochem. Biophys. Res. Commun. , 294 : 116
  • Oberdorster , G. , Maynard , A. , Donaldson , K. , Castranova , V. , Fitzpatrick , J. , Ausman , K. Carter , J. 2005 . Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy . Part Fibre Toxicol , 2 : 8
  • Gulyaev , A. E. , Gelperina , S. E. , Skidan , I. N. , Antropov , A. S. , Kivman , G. Y. and Kreuter , J. 1999 . Significant transport of doxorubicin into the brain with polysorbate 80-coated nanoparticles . Pharm. Res. , 16 : 1564
  • Calvo , P. , Gouritin , B. , Brigger , I. , Lasmezas , C. , Deslys , J. , Williams , A. , Andreux , J. P. , Dormont , D. and Couvreur , P. 2001 . PEGylated polycyanoacrylate nanoparticles as vector for drug delivery in prion diseases . J. Neurosci. Methods , 111 : 151
  • Kreuter , J. 2001 . Nanoparticulate systems for brain delivery of drugs . Adv. Drug. Deliv. Rev. , 47 : 65
  • Oberdorster , G. , Sharp , Z. , Elder , A. P. , Gelein , R. , Kreyling , W. and Cox , C. 2004 . Translocation of inhaled ultrafine particles to the brain . Inhal. Toxicol. , 16 : 437
  • Wang , H. F. , Hu , Y. , Sun , W. Q. and Xie , C. S. 2004 . Polylactic acid nanoparticles across the brain-blood barrier observed with analytical electron microscopy . Sheng Wu Gong Cheng Xue Bao. , 20 : 790
  • Elder , A. , Gelein , R. , Silva , V. , Feikert , T. , Opanashuk , L. , Carter , J. Potter , R. 2006 . Translocation of inhaled ultrafine manganese oxide particles to the central nervous system . Environ. Health Perspect. , 114 : 1172
  • Kashiwada , S. 2006 . Distribution of nanoparticles in the see-through medaka (Oryzias latipes) . Environ. Health Perspect. , 114 : 1697
  • Barile , F. A. , Dierickx , P. J. and Kristen , U. 1994 . In vitro cytotoxicity testing for prediction of acute human toxicity . Cell. Biol. Toxicol. , 10 : 155
  • Eisenbrand , G. , Pool-Zobel , B. , Baker , V. , Balls , M. , Blaauboer , B. J. , Boobis , A. Carere , A. 2002 . Methods of in vitro toxicology . Food Chem. Toxicol. , 40 : 193
  • Lam , C. W. , James , J. T. , Mccluskey , R. and Hunter , R. L. 2004 . Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation . Toxicol. Sci. , 77 : 126
  • Warheit , D. B. , Laurence , B. R. , Reed , K. L. , Roach , D. H. , Reynolds , G. A. and Webb , T. R. 2004 . Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats . Toxicol. Sci. , 77 : 117
  • Shvedova , A. A. , Kisin , E. R. , Mercer , R. , Murray , A. R. , Johnson , V. J. , Potapovich , A. I. Tyurina , Y. Y. 2005 . Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice . Am. J. Physiol. Lung. Cell Mol. Physiol. , 289 : L698
  • Schrand , A. M. , Dai , L. , Schlager , J. J. , Hussain , S. M. and Ôsawa , E. 2007 . Differential biocompatibility of carbon nanotubes and nanodiamonds . Diamond Relat. Mater. , 16 : 2118
  • Swan , A. , Dularay , B. and Dieppe , P. 1990 . A comparison of the effects of urate, hydroxyapatite and diamond crystals on polymorphonuclear cells: Relationship of mediator release to the surface area and adsorptive capacity of different particles . J. Rheumatol. , 17 : 1346
  • Brown , S. L. , Brett , S. M. , Gough , M. , Rodricks , J. V. , Tardiff , R. G. and Turnbull , D. 1988 . Review of interspecies risk comparisons . Regul. Toxicol. Pharmacol. , 8 : 191
  • Brent , R. L. 2004 . Utilization of juvenile animal studies to determine the human effects and risks of environmental toxicants during postnatal developmental stages . Birth Defects Res. B Dev. Reprod Toxicol. , 71 : 303
  • Brent , R. L. 2004 . Utilization of animal studies to determine the effects and human risks of environmental toxicants (drugs, chemicals, and physical agents) . Pediatrics , 113 : 984
  • Kuempel , E. D. 2007 . “ Estimating nanoparticle dose in humans: Issues and challenges ” . In Nanotoxicology: Characterization, dosing, and health effects , Edited by: Tran , M.-R.a. 141 New York : Informa Healthcare .
  • Asgharian , B. and Price , O. T. 2007 . Deposition of ultrafine (NANO) particles in the human lung . Inhalation Toxicol. , 19 : 1045
  • Dai , L. , ed. 2006 . Carbon nanotechnology: Recent developments in chemistry, physics, materials science and device applications , Amsterdam : Elsevier .
  • Shvedova , A. A. , Castranova , V. , Kisin , E. R. , Berry , Schwegler-D. , Murray , A. R. , Gandelsman , V. Z. , Maynard , A. and Baron , P. 2003 . Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells . J. Toxicol. Environ. Health A , 66 : 1909
  • Garibaldi , S. , Brunelli , C. , Bavastrello , V. , Ghigliotti , G. and Nicolini , C. 2006 . Carbon nanotube biocompatibility with cardiac muscle cells . Nanotechnology , 17 : 391
  • Kagan , V. E. , Tyurina , Y. Y. , Tyurin , V. A. , Konduru , N. V. , Potapovich , A. I. , Osipov , A. N. Kisin , E. R. 2006 . Direct and indirect effects of single walled carbon nanotubes on RAW 264.7 macrophages: role of iron . Toxicol. Lett. , 165 : 88
  • Pulskamp , K. , Diabate , S. and Krug , H. F. 2007 . Carbon nanotubes show no sign of acute toxicity but induce intracellular reactive oxygen species in dependence on contaminants . Toxicol. Lett. , 168 : 58
  • Wick , P. , Manser , P. , Limbach , L. K. , Dettlaff-Weglikowska , U. , Krumeich , F. , Roth , S. , Stark , W. J. and Bruinink , A. 2007 . The degree and kind of agglomeration affect carbon nanotube cytotoxicity . Toxicol. Lett. , 168 : 121
  • Daniel , L. N. , Mao , Y. , Wang , T. C. , Markey , C. J. , Markey , S. P. , Shi , X. and Saffiotti , U. 1995 . DNA strand breakage, thymine glycol production, and hydroxyl radical generation induced by different samples of crystalline silica in vitro . Environ. Res. , 71 : 60
  • Ball , J. C. , Straccia , A. M. , Young , W. C. and Aust , A. E. 2000 . The formation of reactive oxygen species catalyzed by neutral, aqueous extracts of NIST ambient particulate matter and diesel engine particles . J. Air. Waste Manag. Assoc. , 50 : 1897
  • Long , J. F. , Waldman , W. J. , Kristovich , R. , Williams , M. , Knight , D. and Dutta , P. K. 2005 . Comparison of ultrastructural cytotoxic effects of carbon and carbon/iron particulates on human monocyte-derived macrophages . Environ. Health Perspect , 113 : 170
  • Carrero-Sanchez , J. C. , Elias , A. L. , Mancilla , R. , Arrellin , G. , Terrones , H. , Laclette , J. P. and Terrones , M. 2006 . Biocompatibility and toxicological studies of carbon nanotubes doped with nitrogen . Nano. Lett. , 6 : 1609
  • Manna , S. K. , Sarkar , S. , Barr , J. , Wise , K. , Barrera , E. V. , Jejelowo , O. , Rice-Ficht , A. C. and Ramesh , G. T. 2005 . Single-walled carbon nanotube induces oxidative stress and activates nuclear transcription factor-kappaB in human keratinocytes . Nano. Lett. , 5 : 1676
  • Oberdörster , E. , Zhu , S. , Blickley , T. , Mcclellan-Green , P. and Haasch , M. 2006 . Ecotoxicology of carbon-based engineered nanoparticles: effects of fullerene (C60) on aquatic organisms . Carbon , 44 : 1112
  • Zhang , Q. , Kusaka , Y. , Sato , K. , Mo , Y. , Fukuda , M. and Donaldson , K. 1998 . Toxicity of ultrafine nickel particles in lungs after intratracheal instillation . J. Occup. Health , 40 : 171
  • Donaldson , K. , Beswick , P. H. and Gilmour , P. S. 1996 . Free radical activity associated with the surface of particles: a unifying factor in determining biological activity? . Toxicol. Lett. , 88 : 293
  • Zhang , Q. , Kusaka , Y. , Zhu , X. , Sato , K. , Mo , Y. , Kluz , T. and Donaldson , K. 2003 . Comparative toxicity of standard nickel and ultrafine nickel in lung after intratracheal instillation . J. Occup. Health , 1 : 23
  • Sato , Y. , Yokoyama , A. , Shibata , K. , Akimoto , Y. , Ogino , S. , Nodasaka , Y. Kohgo , T. 2005 . Tohji, Influence of length on cytotoxicity of multi-walled carbon nanotubes against human acute monocytic leukemia cell line THP-1 in vitro and subcutaneous tissue of rats in vivo . Mol. Biosyst. , 1 : 176
  • Sayes , C. M. , Gobin , A. M. , Ausman , K. D. , Mendez , J. , West , J. L. and Colvin , V. L. 2005 . Nano-C60 cytotoxicity is due to lipid peroxidation . Biomaterials , 26 : 7587
  • Bottini , M. , Bruckner , S. , Nika , K. , Bottini , N. , Bellucci , S. , Magrini , A. , Bergamaschi , A. and Mustelin , T. 2006 . Multi-walled carbon nanotubes induce T lymphocyte apoptosis . Toxicol. Lett. , 160 : 121
  • Magrez , A. , Kasas , S. , Salicio , V. , Pasquier , N. , Seo , J. W. , Celio , M. Catsicas , S. 2006 . Cellular toxicity of carbon-based nanomaterials . Nano. Lett. , 6 : 1121
  • Jia , G. , Wang , H. , Yan , L. , Wang , X. , Pei , R. , Yan , T. , Zhao , Y. and Guo , X. 2005 . Cytotoxicity of carbon nanomaterials: single-wall nanotube, multi-wall nanotube, and fullerene . Environ. Sci. Technol. , 39 : 1378
  • Grabinski , C. , Hussain , S. , Lafdi , K. , Braydich-Stolle , L. and Schlager , J. 2007 . Effect of particle dimension on biocompatibility of carbon nanomaterials . Carbon , 45 : 2828
  • Wilson , M. R. , Lightbody , J. H. , Donaldson , K. and Al , E. 2002 . Interactions between ultrafine particles and transition metals in vivo and in vitro . Toxicol. Appl. Pharmacol. , 184 : 172
  • Gilmour , P. S. , Ziesenis , A. , Morrison , E. R. , Vickers , M. A. , Drost , E. M. Ford , I. 2004 . Pulmonary and systemic effects of short-term inhalation exposure to ultrafine carbon black particles . Toxicol. Appl. Pharmacol. , 195 : 35
  • Price , R. L. , Haberstoh , K. M. and Webster , T. J. 2004 . Improved osteoblast viability in the presence of smaller nanometer dimensioned carbon fibres . Nanotechnology , 15 : 892
  • Liu , C. , Huang , H. , Song , P. and Fan , S. 2007 . Machining carbon nanotubes into uniform slices . J. Nanosci. Nanotechnol. , 7 : 4473
  • Ashikaga , T. , Wada , M. , Kobayashi , H. , Mori , M. , Katsumura , Y. , Fukui , H. Kato , S. 2000 . Effect of the photocatalytic activity of TiO(2) on plasmid DNA . Mutat. Res. , 466 : 1
  • Brown , D. M. , Stone , V. , Findlay , P. , Macnee , W. and Donaldson , K. 2000 . Increased inflammation and intracellular calcium caused by ultrafine carbon black is independent of transition metals or other soluble components . Occup. Environ. Med. , 57 : 685
  • Brown , D. M. , Wilson , M. R. , Macnee , W. , Stone , V. and Donaldson , K. 2001 . Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines . Toxicol. Appl. Pharmacol. , 175 : 191
  • Hohr , D. , Steinfartz , Y. , Schins , R. P. , Knaapen , A. M. , Martra , G. , Fubini , B. and Borm , P. J. 2002 . The surface area rather than the surface coating determines the acute inflammatory response after instillation of fine and ultrafine TiO2 in the rat . Int. J. Hyg. Environ. Health , 205 : 239
  • Rehn , B. , Seiler , F. , Rehn , S. , Bruch , J. and Maier , M. 2003 . Investigations on the inflammatory and genotoxic lung effects of two types of titanium dioxide: Untreated and surface treated . Toxicol. Appl. Pharmacol. , 189 : 84
  • Hoshino , A. , Kujioka , F. , Oku , T. , Suga , M. , Sasaki , Y. F. , Ohta , T. , Yasuhara , M. , Suzuki , K. and Yamamoto , K. 2004 . Physicochemical properties and cellular toxicity of nanocrystal quantum dots depend on their surface modification . Nano. Lett. , 4 : 2163
  • Muller , M. , Mackeben , S. and Muller-Goymann , C. C. 2004 . Physicochemical characterisation of liposomes with encapsulated local anaesthetics . Int. J. Pharm. , 1-2 : 139
  • Ding , L. , Stilwell , J. , Zhang , T. , Elboudwarej , O. , Jiang , H. , Selegue , J. P. Cooke , P. A. 2005 . Molecular characterization of the cytotoxic mechanism of multiwall carbon nanotubes and nano-onions on human skin fibroblast . Nano. Lett. , 5 : 2448
  • Kirchner , C. , Liedl , T. , Kudera , S. , Pellegrino , T. , Munoz , A. Javier , Gaub , H. E. Stolzle , S. 2005 . Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles . Nano. Lett. , 5 : 331
  • Soto , K. , Carrasco , A. , Powell , T. , Garza , K. and Murr , L. 2005 . Comparative In vitro cytotoxicity assessment of some manufactured nanoparticulate materials characterized by transmission electron microscopy . J. Nanopart. Res. , 7 : 145
  • Chithrani , B. D. , Ghazani , A. A. and Chan , W. C. 2006 . Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells . Nano. Lett. , 6 : 662
  • Sayes , C. M. , Liang , F. , Hudson , J. L. , Mendez , J. , Guo , W. , Beach , J. M. Moore , V. C. 2006 . Colvin, Functionalization density dependence of single-walled carbon nanotubes cytotoxicity in vitro . Toxicol. Lett. , 161 : 135
  • Chen , H. W. , Su , S. F. , Chien , C. T. , Lin , W. H. , Yu , S. L. , Chou , C. C. , Chen , J. J. and Yang , P. C. 2006 . Titanium dioxide nanoparticles induce emphysema-like lung injury in mice . FASEB J. , 20 : 2393
  • Warheit , D. B. , Webb , T. R. , Sayes , C. M. , Colvin , V. L. and Reed , K. L. 2006 . Pulmonary instillation studies with nanoscale TiO2 rods and dots in rats: Toxicity is not dependent upon particle size and surface area . Toxicol. Sci. , 91 : 227
  • Xu , Z. P. , Zeng , Q. H. , Gq , G. Q. L. and Ui , A. B. 2006 . Inorganic nanoparticles as carriers for efficient cellular delivery . Chem. Engineer. Sci. , 61 : 1027
  • Pal , S. , Tak , Y. K. and Song , J. M. 2007 . Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli . Appl. Environ. Microbiol. , 73 : 1712
  • Corona-Morales , A. A. , Castell , A. and Al , E. 2003 . Fullerene C60 and ascorbic acid protect cultured chromaffin cells against levodopa toxicity . J. Neurosci. Res. , 71 : 121
  • Bogdanovic , G. , Kojic , V. , Dordevic , A. , Brunet , Canadanovic-J. , Vojinovic-Miloradov , M. and Baltic , V. V. 2004 . Modulating activity of fullerol C60(OH)22 on doxorubicin-induced cytotoxicity . Toxicol. In Vitro , 18 : 629
  • Monteiro-Riviere , N. A. , Inman , A. O. , Wang , Y. Y. and Nemanich , R. J. 2005 . Surfactant effects on carbon nanotube interactions with human keratinocytes . Nanomedicine , 1 : 293
  • Monteiro-Riviere , N. A. , Nemanich , R. J. , Inman , A. O. , Wang , Y. Y. and Riviere , J. E. 2005 . Multi-walled carbon nanotube interactions with human epidermal keratinocytes . Toxicol. Lett. , 155 : 377
  • Witzmann , F. A. and Monteiro-Riviere , N. A. 2006 . Multi-walled carbon nanotube exposure alters protein expression in human keratinocytes . Nanomedicine , 2 : 158
  • Sayes , C. M. , Marchione , A. A. , Reed , K. L. and Warheit , D. B. 2007 . Comparative pulmonary toxicity assessments of C60 water suspensions in rats: few differences in fullerene toxicity in vivo in contrast to in vitro profiles . Nano. Lett. , 7 : 2399
  • Sayes , C. M. , Reed , K. L. and Warheit , D. B. 2007 . Assessing toxicity of fine and nanoparticles: Comparing in vitro measurements to in vivo pulmonary toxicity profiles . Toxicol. Sci. , 97 : 163
  • Schrand , A. M. , Szcublewski , K. , Schlager , J. J. , Dai , L. and Hussain , S. M. 2007 . Interaction and biocompatibility of multi-walled carbon nanotubes in PC-12 cells . Int. J. Neuroprotection Neuroregeneration , 3 : 115
  • Tse , R. L. and Phelps , P. 1970 . Polymorphonuclear leukocyte motility in vitro. V. Release of chemotactic activity following phagocytosis of calcium pyrophosphate crystals, diamond dust, and urate crystals . J. Lab. Clin. Med. , 76 : 403
  • Higson , F. K. and Jones , O. T. 1984 . Oxygen radical production by horse and pig neutrophils induced by a range of crystals . J. Rheumatol. , 11 : 735
  • Hedenborg , M. and Klockars , M. 1989 . Quartz-dust-induced production of reactive oxygen metabolites by human granulocytes . Lung , 167 : 23
  • Schmidt , J. A. , Oliver , C. N. , Lepe-Zuniga , J. L. , Green , I. and Gery , I. 1984 . Silica-stimulated monocytes release fibroblast proliferation factors identical to interleukin 1. A potential role for interleukin 1 in the pathogenesis of silicosis . J. Clin. Invest. , 73 : 1462
  • Allison , H. J. and Birbeck , M . 1966 . An examination of the cytotoxic effects of silica on macrophages . J. Exp. Med. , 124 : 141
  • Nordsletten , L. , Hogasen , A. K. , Konttinen , Y. T. , Santavirta , S. , Aspenberg , P. and Aasen , A. O. 1996 . Human monocytes stimulation by particles of hydroxyapatite, silicon carbide and diamond: in vitro studies of new prosthesis coatings . Biomaterials , 17 : 1521
  • Luhr , H. G. 1958 . Comparative studies on phagocytosis of coal powders of various carbonification grades, also of quartz and diamond powders in tissue cultures . Arch. Gewerbepathol. Gewerbehyg. , 16 : 355
  • Cheung , H. S. , Story , M. T. and Mccarty , D. J. 1984 . Mitogenic effects of hydroxyapatite and calcium pyrophosphate dihydrate crystals on cultured mammalian cells . Arthritis Rheum. , 27 : 668
  • Dion , I. , Bordenave , L. , Lefebvre , F. , Bareille , R. , Baquey , C. , Monties , J. R. and Havlik , P. 1994 . Physico-chemistry and cytotoxicity of ceramics part II: Cytotoxicity of ceramics . J. Mater. Sci.: Mater. Med. , 5 : 18
  • Dion , I. , Lahaye , M. , Salmon , R. , Baquey , C. , Monties , J. R. and Havlik , P. 1993 . Blood haemolysis by ceramics . Biomaterials , 14 : 107
  • Blanco , V. , Lopez , J. Camelo and Carri , N. G. 2001 . Growth inhibition, morphological differentiation and stimulation of survival in neuronal cell type (Neuro-2a) treated with trophic molecules . Cell. Biol. Int. , 25 : 909
  • Puzyr , A. P. , Neshumayev , D. A. , Bondar , V. S. , Dolmatov , V. Y. , Shugalei , I. V. , Dubyago , N. P. , Tarskikh , S. V. and Makarskaya , G. V. . The influence of detonation nanodiamond powder on blood cells . Proceedings of NATO Advanced Research Workshop, Innovative superhard materials and sustainable coating, vol. 200 . Netherlands : Springer .
  • Puzyr , A. P. , Tarskikh , S. V. , Makarskaya , G. V. , Chiganova , G. A. , Larionova , I. S. , Detkov , P. Y. and Bondar , V. S. 2002 . Damaging effect of detonation diamonds on human white and red blood cells in vitro . Dokl. Biochem. Biophys. , 385 : 201
  • Puzyr , A. P. , Neshumayev , D. A. , Tarskikh , S. V. , Makarskaya , G. V. , Dolmatov , V. and Bondar , V. S. 2004 . Destruction of human blood vells in interaction with detonation nanodiamonds in experiments in vitro . Diamond Relat. Mater. , 13 : 2020
  • Puzyr , A. P. , Neshumaev , D. A. , Tarskikh , S. V. , Makarskaia , G. V. , Dolmatov , V. and Bondar , V. S. 2005 . Destruction of human blood cells upon interaction with detonation nanodiamonds in experiments in vitro . Biofizika , 50 : 101
  • Nosé , Y. 1991 . What is blood compatibility? . Aritificial Organs , 15 : 1
  • Dion , I. , Roques , X. , Baquey , C. , Baudet , E. , Basse , B. Cathalinat and More , N. 1993 . Hemocompatibility of diamond-like carbon coating . Biomed. Mater. Eng. , 3 : 51
  • Spilberg , I. , Mehta , J. and Simchowitz , L. 1982 . Induction of a chemotactic factor from human neutrophils by diverse crystals . J. Lab. Clin. Med. , 100 : 399
  • Tu , J. S. , Perevedentseva , E. , Chung , P. H. and Cheng , C. L. 2006 . Size-dependent surface CO stretching frequency investigations on nanodiamond particles . J. Chem. Phys. , 125 : 174713
  • Muller , J. , Huaux , F. , Moreau , N. , Misson , P. , Heilier , J. F. , Delos , M. , Arras , M. , Fonseca , A. , Nagy , J. B. and Lison , D. 2005 . Respiratory toxicity of multi-wall carbon nanotubes . Toxicol. Appl. Pharmacol. , 207 : 221
  • Donaldson , K. , Aitken , R. , Tran , L. , Stone , V. , Duffin , R. , Forrest , G. and Alexander , A. 2006 . Carbon nanotubes: A review of their properties in relation to pulmonary toxicology and workplace safety . Toxicol. Sci. , 92 : 5
  • Leeuw , T. K. , Reith , R. M. , Simonette , R. A. , Harden , M. E. , Cherukuri , P. , Tsyboulski , D. A. , Beckingham , K. M. and Weisman , R. B. 2007 . Single-walled carbon nanotubes in the intact organism: near-IR imaging and biocompatibility studies in Drosophila . Nano. Lett. , 7 : 2650
  • Tsuchiya , T. , Oguri , I. , Yamakoshi , Y. N. and Miyata , N. 1996 . Novel harmful effects of [60]fullerene on mouse embryos in vitro and in vivo . FEBS Lett. , 393 : 139
  • Ueng , T. H. , Kang , J. J. , Wang , H. W. , Cheng , Y. W. and Chiang , L. Y. 1997 . Suppression of microsomal cytochrome P450-dependent monooxygenases and mitochondrial oxidative phosphorylation by fullerenol, a polyhydroxylated fullerene C60 . Toxicol. Lett. , 93 : 29
  • Usenko , C. Y. , Harper , S. L. and Tanguay , R. L. 2007 . In vivo evaluation of carbon fullerene toxicity using embryonic zebrafish . Carbon N Y , 45 : 1891
  • Baker , G. L. , Gupta , A. , Clark , M. L. , Valenzuela , B. R. , Staska , L. M. , Harbo , S. J. , Pierce , J. T. and Dill , J. A. 2008 . Inhalation toxicity and lung toxicokinetics of C60 fullerene nanoparticles and microparticles . Toxicol. Sci. , 101 : 122
  • Tykhomyrov , A. A. , Nedzvetsky , V. S. , Klochkov , V. K. and Andrievsky , G. V. 2008 . Nanostructures of hydrated C60 fullerene (C60HyFn) protect rat brain against alcohol impact and attenuate behavioral impairments of alcoholized animals . Toxicology , 246 : 158
  • Baun , A. , Hartmann , N. B. , Grieger , K. and Kusk , K. O. 2008 . Ecotoxicity of engineered nanoparticles to aquatic invertebrates: A brief review and recommendations for future toxicity testing . Ecotoxicology , 17 : 387
  • Aspenberg , P. , Anttila , A. , Konttinen , Y. T. , Lappalainen , R. , Goodman , S. B. , Nordsletten , L. and Santavirta , S. 1996 . Benign response to particles of diamond and SiC: Bone chamber studies of new joint replacement coating materials in rabbits . Biomaterials , 17 : 807
  • Doherty , M. , Whicher , J. T. and Dieppe , P. A. 1983 . Activation of the alternative pathway of complement by monosodium urate monohydrate crystals and other inflammatory particles . Ann. Rheum. Dis. , 42 : 285
  • Puzyr , A. P. , Bondar , V. S. and Al , S. E. 2004 . Dynamics of the selected physiological responses in laboratory mice under the prolonged oral administration of nanodiamonds suspensions . Siberian Med. Obozrenie (Siberian Med. Rev.) (in Russian) , 4 : 19
  • Puzyr , A. P. , Bondar , V. S. , Selimhanova , Z. Y. , Tyan , A. G. , Bortnikov , E. V. and Injevatkin , E. V. 2004 . Results of studies of possible applications of detonation nanodiamonds as enterosorbents . Siberian Med. Obozrenie (Siberian Med. Rev.) (in Russian) , 2-3 : 25
  • Bondar , V. Baron , D. 2005 . Changes in bio-chemical parameters of blood plasma at administration of nanodiamond to laboratory animals . Bull. Siberian Medi. (in Russian) , 4 : 182
  • Puzyr , A. P. , Bondar , V. S. , Selimkhanova , Z. Y. , Tyan , A. G. , Inzhevatkin , E. V. and Bortnikov , E. V. 2005 . Results of in vitro and in vivo studies using detonation nanodiamonds/complex systems under extreme conditions . KSC SB RAS, Krasnoyarsk , : 229
  • Puzyr , A. P. , Bondar , V. S. , Selimkhanova , A. G. , Tyan , E. V. , Inzhevatkin Bondar , V. S. and Baron , D. 2005 . Physiological parameters of laboratory animals at oral administration of nanodiamond hydrosols . Bull. Siberian Medi. (in Russian) , 4 : 185
  • Puzyr , A. P. , Bortnikov , E. V. , Skobelev , N. N. , Tyan , A. G. , Yu , Z. , Selimkhanova , G. G. , Manashev , G. G. and Bondar , V. S. 2005 . A possibility of using of intravenous administration of sterile colloids of modified nanodiamonds . Siberian Med. Obozrenie/ Siberian Med. Rev. (in Russian) , 1 : 20
  • Dolmatov , V. Y. and Kostrova , L. N. 2000 . Detonation-synthesized nanodiamonds and the feasibility of developing a new generation of medicinals . Superhard Mater. (in Russian) , 3 : 82
  • Maxwell , H. 1988 . The Poisoner's Handbook , Port Townsend, WA : Loompanics Unlimited .
  • Davies , G. 1984 . Diamond , Bristol : Adam Hilger Ltd. .
  • Huang , T. S. , Tzeng , Y. , Liu , Y. K. , Chen , Y. K. , Walker , K. R. , Guntupalli , R. and Liu , C. 2004 . Immobilization of antibodies and bacterial binding on nanodiamond and carbon nanotubes for biosensor applications . Diamond Relat. Mater. , 13 : 1098
  • Warheit , D. B. , Webb , T. R. , Colvin , V. L. , Reed , K. L. and Sayes , C. M. 2007 . Pulmonary bioassay studies with nanoscale and fine-quartz particles in rats: toxicity is not dependent upon particle size but on surface characteristics . Toxicol. Sci. , 95 : 270
  • Gomez , D. E. , Pastoriza-Santos , I. and Mulvaney , P. 2005 . Tunable whispering gallery mode emission from quantum-dot-doped microspheres . Small , 1 : 238
  • Lovric , J. , Cho , S. J. , Winnik , F. M. and Maysinger , D. 2005 . Unmodified cadmium telluride quantum dots induce reactive oxygen species formation leading to multiple organelle damage and cell death . Chem. Biol. , 12 : 1227
  • Hardman , R. 2006 . A toxicologic review of quantum dots: Toxicity depends on physicochemical and environmental factors . Environ. Health Perspect. , 114 : 165
  • Smith , A. M. , Ruan , G. , Rhyner , M. N. and Nie , S. 2006 . Engineering luminescent quantum dots for in vivo molecular and cellular imaging . Ann. Biomed. Eng. , 34 : 3
  • Hoshino , A. , Manabe , N. , Fujioka , K. , Suzuki , K. , Yasuhara , M. and Yamamoto , K. 2007 . Use of fluorescent quantum dot bioconjugates for cellular imaging of immune cells, cell organelle labeling, and nanomedicine: Surface modification regulates biological function, including cytotoxicity . J. Artif. Organs , 10 : 149
  • Liu , W. , Choi , H. S. , Zimmer , J. P. , Tanaka , E. , Frangioni , J. V. and Bawendi , M. 2007 . Compact cysteine-coated CdSe(ZnCdS) quantum dots for in vivo applications . J. Am. Chem. Soc. , 129 : 14530
  • Maysinger , D. and Lovric , J. 2007 . Quantum dots and other fluorescent nanoparticles: Quo vadis in the cell? . Adv. Exp. Med. Biol. , 620 : 156
  • Maysinger , D. , Behrendt , M. , Hebert , Lalancette-M. and Kriz , J. 2007 . Real-time imaging of astrocyte response to quantum dots: in vivo screening model system for biocompatibility of nanoparticles . Nano. Lett. , 7 : 2513
  • Maysinger , D. 2007 . Nanoparticles and cells: Good companions and doomed partnerships . Org. Biomol. Chem. , 5 : 2335
  • Maysinger , D. , Lovric , J. , Eisenberg , A. and Savic , R. 2007 . Fate of micelles and quantum dots in cells . Eur. J. Pharm. Biopharm. , 65 : 270
  • Tan , W. B. , Jiang , S. and Zhang , Y. 2007 . Quantum-dot based nanoparticles for targeted silencing of HER2/neu gene via RNA interference . Biomaterials , 28 : 1565
  • Choi , A. O. , Brown , S. E. , Szyf , M. and Maysinger , D. 2008 . Quantum dot-induced epigenetic and genotoxic changes in human breast cancer cells . J. Mol. Med. , 86 : 291
  • Liu , W. , Howarth , M. , Greytak , A. B. , Zheng , Y. , Nocera , D. G. , Ting , A. Y. and Bawendi , M. G. 2008 . Compact biocompatible quantum dots functionalized for cellular imaging . J. Am. Chem. Soc. , 130 : 1274
  • Liu , T. C. , Zhang , H. L. , Wang , J. H. , Wang , H. Q. , Zhang , Z. H. , Hua , X. F. Cao , Y. C. 2008 . Study on molecular interactions between proteins on live cell membranes using quantum dot-based fluorescence resonance energy transfer . Anal. Bioanal. Chem. , 391 : 2819
  • Anisimov , V. N. , Zabezhinski , M. A. , Popovich , I. G. , Lieberman , A. I. and Shmidt , J. L. 1998 . Prevention of spontaneous and chemically-induced carcinogenesis using activated carbon fiber adsorbent. I. Effect of the activated carbon fiber adsorbent ‘Aqualen’ on spontaneous carcinogenesis and life-span in mice . Cancer. Lett. , 126 : 23
  • Anisimov , V. N. , Zabezhinski , M. A. , Popovich , I. G. , Berstein , L. M. , Kovalenko , I. G. , Lieberman , A. I. and Shmidt , J. L. 1999 . Prevention of spontaneous and chemically induced carcinogenesis using activated carbon fiber adsorbent. III. Inhibitory effect of the activated carbon fiber adsorbent ‘Aqualen’ on 1,2-dimethylhydrazine-induced intestinal carcinogenesis in rats . Cancer Lett. , 138 : 27
  • Anisimov , V. N. , Zabezhinski , M. A. , Popovich , I. G. , Lieberman , A. I. and Shmidt , J. L. 1999 . Prevention of spontaneous and chemically induced carcinogenesis using activated carbon fiber adsorbent. II. Inhibitory effect of the activated carbon fiber adsorbent ‘Aqualen’ on N-methyl-N′ -nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats . Cancer Lett. , 138 : 23
  • Phillips , T. D. 1999 . Dietary clay in the chemoprevention of aflatoxin-induced disease . Toxicol. Sci. , 52 : 118
  • Grichko , V. , Grishko , V. and Shenderova , O. 2006 . Nanodiamond bullets and their biological targets . Nanobiotechnology , 2 : 37
  • Ushizawa , K. , Sato , Y. , Mitsumori , T. , Machinami , T. , Ueda , T. and Ando , T. 2002 . Covalent immobilization of DNA on diamond and its verification by diffuse reflectance infrared spectroscopy . Chem. Phys. Lett. , 351 : 105
  • Ibrahim , H. R. , Yamada , M. , Matsushita , K. , Kobayashi , K. and Kato , A. 1994 . Enhanced bactericidal action of lysozyme to Escherichia coli by inserting a hydrophobic pentapeptide into its C terminus . J. Biol. Chem. , 269 : 5059
  • Pace , C. N. , Vajdos , F. , Fee , L. , Grimsley , G. and Gray , T. 1995 . How to measure and predict the molar absorption coefficient of a protein . Protein. Sci. , 4 : 2411
  • Nguyen , T. T. B. , Chang , H. C. and Wu , V. W. K. 2007 . Adsorption and hydrolytic activity of lysozyme on diamond nanocrystallites . Diamond Relat. Mater. , 16 : 872
  • Bojkova , A. I. , Shilova , O. A. , Golikova , E. V. , Nikolajchuk , N. I. , Khamova , T. V. , Hashkovskij , S. V. , Vlasov , D. Y. , Frank-Kamenetsky , O. V. and Dolmatov , V. Y. . Detonation nanodiamond additives influence on strength and bioproofness of multiphase portland cement clinker materials . Nanotechnology International Forum/Rusanotech 1908, Abstracts, V. 1M . pp. 488 – 489 . RUSNANO .
  • Kossovsky , N. , Gelman , A. , Hnatyszyn , H. J. , Rajguru , S. , Garrell , R. L. , Torbati , S. , Freitas , S. S. and Chow , G. M. 1995 . Surface-modified diamond nanoparticles as antigen delivery vehicles . Bioconjug Chem. , 6 : 507
  • Bianco , A. , Wu , W. , Pastorin , G. , Klumpp , C. , Lacerda , L. , Partidos , C. D. , Kostarelos , K. and Prato , M. 2007 . “ Carbon nanotube-based vectors for delivering Immunotherapeutics and Drugs ” . In Nanotechnologies for the life sciences , Edited by: Kumar , C. 85 New York : Wiley-VCH Verlag GmbH & Co. KgaA .
  • Bianco , A. , Hoebeke , J. , Godefroy , S. , Chaloin , O. , Pantarotto , D. , Briand , J. P. , Muller , S. , Prato , M. and Partidos , C. D. 2005 . Cationic carbon nanotubes bind to CpG oligodeoxynucleotides and enhance their immunostimulatory properties . J. Am. Chem. Soc. , 127 : 58
  • Pantarotto , D. , Partidos , C. D. , Graff , R. , Hoebeke , J. , Briand , J. P. , Prato , M. and Bianco , A. 2003 . Synthesis, structural characterization, and immunological properties of carbon nanotubes functionalized with peptides . J. Am. Chem. Soc. , 125 : 6160
  • Pantarotto , D. , Partidos , C. D. , Hoebeke , J. , Brown , F. , Kramer , E. , Briand , J. P. , Muller , S. , Prato , M. and Bianco , A. 2003 . Immunization with peptide-functionalized carbon nanotubes enhances virus-specific neutralizing antibody responses . Chem. Biol. , 10 : 961
  • Huang , H. J. , Pierstorff , E. , Osawa , E. and Ho , D. 2008 . Protein-mediated assembly of nanodiamond hydrogels into a biocompatible and biofunctional multilayer nanofilm . ACS Nano. , 2 : 203
  • Liu , K. K. , Chen , F. , Chen , P. Y. , Lee , T. J. F. , Cheng , C. L. , Chang , C. C. , Ho , Y. P. and Chao , J. I. 2008 . Alpha-bungarotoxin binding to target cell in a developing visual system by carboxylated nanodiamond . Nanotechnology , 19
  • Dolmatov , V. Y. 2003 . Detonation synthesis ultradispersed diamonds (Russian edition) , Publ.house of Saint-Petersburg State Polytechnic University Saint-Petersburg .
  • Dolmatov , V. Y. “ Biologically active detonation synthesis of ultradispersed diamonds ” . Publ. 27.04.: Russian Federation, A61 K 33/44 2003
  • Nachalnaya , T. A. , Malogolovets , V. G. , Podzerei , G. A. , Nikitin , Yu. I. , Novikov , N. V. and Polkanov , Yu. A. 2000 . Special features of structure and physico-mechanical properties of natural diamonds of Ukraine . Superhard materials (in Russian) , 22 : 33
  • Barushkina , T. N. , Aleinikov , V. G. , Donster , B. B. and Savvakin , G. I. . Chemical modification of diamond surface with ozone (Russian edition) . Proceedings of Institute of Superhard Materials of Ukrainian Academy of Sciences .
  • Hauert , R. 2003 . A review of modified DLC coatings for biological applications . Diamond Relat. Mater. , 12 : 583
  • Amaral , M. and Abreu , C. S. 2007 . Biotribological performace of NCD coated Si2N4-bioglass composites . Diamond Relat. Mater. , 16 : 790
  • Mitura , S. , Mitura , A. , Niedzielski , P. and Couvrat , P. 1999 . Nanocrystalline diamond coatings . Chaos Solitons Fractals , 10 : 2165
  • Xiao , X. C. , Wang , J. , Liu , C. , Carlisle , J. A. , Mech , B. , Greenberg , R. Guven , D. 2006 . Auciello, In vitro and in vivo evaluation of ultrananocrystalline diamond for coating of implantable retinal microchips . J. Biomed. Mater. Res. Part B-Appl. Biomater. , 77B : 273
  • Feygelson , T. I. , Shenderova , O. , Hens , S. , Cunningham , G. , Hobart , K. D. and Butler , J. E. . Detonation nanodiamond slurries for nucleation of CVD diamond films . Third International Symposium Detonation Nanodiamonds: Technology, Properties and Applications . St. Petersburg, Russia.
  • Pramatarova , L. , Pecheva , E. , Stavrev , S. , Spasov , T. , Montgomery , P. , Toth , A. , Dimitrova , M. and Apostolova , M. 2007 . Artificial bones through nanodiamonds . J. Optoelectronics Adv. Mater. , 9 : 236
  • Chien-Min , S. , Michael , S. and Emily , S. Healthcare and cosmetic compositions containing nanodiamond . US Patent 7, 294, 340 .
  • Lunkin , V. V. Patent: Cosmetic Composition . RU 2257889 .
  • Environmental Working Group . www.cosmeticdatabase.com
  • Gasparro , F. P. , Mitchnick , M. and Nash , J. F. 1998 . A review of sunscreen safety and efficacy . Photochemi. Photobiol. , 68 : 243
  • Cockell , C. S. and Knowland , J. 1999 . Ultraviolet radiation screening compounds . Biol. Rev. , 74 : 311
  • Nash , J. F. 2006 . Human safety and efficacy of ultraviolet filters and sunscreen products . Dermatolo. Clin. , 24 : 35
  • Zaitsev , A. M. 2001 . Optical Properties of Diamond , New York : Springer .
  • Duffin , R. , Gilmour , P. S. , Schins , R. P. , Clouter , A. , Guy , K. , Brown , D. M. , Macnee , W. , Borm , P. J. , Donaldson , K. and Stone , V. 2001 . Aluminium lactate treatment of DQ12 quartz inhibits its ability to cause inflammation, chemokine expression, and nuclear factor-kappaB activation . Toxicol. Appl. Pharmacol. , 176 : 10
  • Ōsawa , E. 2008 . Mono-disperse single-nano diamond particulates . Pure Appl. Chem. , 80 : 1365
  • Teeguarden , J. G. , Hinderliter , P. M. , Orr , G. , Thrall , B. D. and Pounds , J. G. 2007 . Particokinetics in vitro: Dosimetry considerations for in vitro nanoparticle toxicity assessments . Toxicol. Sci. , 95 : 300
  • Dutta , N. and Green , D. 2008 . Nanoparticle stability in semidilute and concentrated polymer solutions . Langmuir , 24 : 5260
  • Hanauer , M. , Pierrat , S. , Zins , I. , Lotz , A. and Sonnichsen , C. 2007 . Separation of nanoparticles by gel electrophoresis according to size and shape . Nano Lett. , 7 : 2881
  • Monteiro-Riviere , N. A. , Inman , A. O. , Barlow , B. M. and Baynes , R. E. 2006 . Dermatotoxicity of cutting fluid mixtures: in vitro and in vivo studies . Cutan. Ocul. Toxicol. , 25 : 235
  • Worle-Knirsch , J. M. , Pulskamp , K. and Krug , H. F. 2006 . Oops they did it again! Carbon nanotubes hoax scientists in viability assays . Nano. Lett. , 6 : 1261
  • Hoet , P. , Nemmar , A. , Nemery , B. and Hoylaerts , M. 2007 . “ Hemostatic and thrombotic effects of particulate exposure: assessing the mechanisms ” . In Nanotoxicology: characterization, dosing, and health effects , Edited by: Monteiro-Riviere , N. a.T. C. 247 Informa Healthcare .
  • Cui , D. , Tian , F. , Ozkan , C. S. , Wang , M. and Gao , H. 2005 . Effect of single wall carbon nanotubes on human HEK293 cells . Toxicol. Lett. , 155 : 73
  • Cunningham , M. J. , Magnuson , S. R. and Falduto , M. T. 2005 . Gene expression profiling of nanoscale materials using a systems biology approach . Toxicol. Sci. , 84 : 9
  • Jia , N. , Lian , Q. , Shen , H. , Wang , C. , Li , X. and Yang , Z. 2007 . Intracellular delivery of quantum dots tagged antisense oligodeoxynucleotides by functionalized multiwalled carbon nanotubes . Nano. Lett. , 7 : 2976
  • Cao , L. , Wang , X. , Meziani , M. J. , Lu , F. , Wang , H. , Luo , P. G. Lin , Y. 2007 . Carbon dots for multiphoton bioimaging . J. Am. Chem. Soc. , 129 : 11318
  • Geiser , M. , Rothen-Rutishauser , B. , Kapp , N. , Schurch , S. , Kreyling , W. , Schulz , H. Semmler , M. 2005 . Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells . Environ. Health Perspect. , 113 : 1555
  • Ricarda-Lorenz , M. , Holzapfel , V. , Musyanovych , A. , Nothelfer , K. , Walther , P. , Frank , H. Landfester , K. 2006 . Uptake of functionalized, fluorescent-labeled polymeric particles in different cell lines and stem cells . Biomaterials , 27 : 2820
  • Lin , D. and Xing , B. 2007 . Phytotoxicity of nanoparticles: Inhibition of seed germination and root growth . Environ. Pollut. , 150 : 243
  • Morozan , A. S. , Nastase , F. , Dumitru , A. , Vulpe , S. , Nastase , C. , Stamatin , T. and Scott , K. 2007 . The biocompatibility microorganisms-carbon nanostructures for applications in microbial fuel cells . Physica Status Solidi (A) , 204 : 1797
  • Inoue , K. , Takano , H. , Yanagisawa , R. , Hirano , S. , Sakurai , M. , Shimada , A. and Yoshikawa , T. 2006 . Effects of airway exposure to nanoparticles on lung inflammation induced by bacterial endotoxin in mice . Environ. Health Perspectives , 114 : 1325
  • Han , S. W. , Nakamura , C. , Obataya , I. , Nakamura , N. and Miyake , J. 2005 . Gene expression using an ultrathin needle enabling accurate displacement and low invasiveness . Biochem. Biophys. Res. Commun. , 332 : 633
  • Choi , J. H. , Nguyen , F. T. , Barone , P. W. , Heller , D. A. , Moll , A. E. , Patel , D. , Boppart , S. A. and Strano , M. S. 2007 . Multimodal biomedical imaging with asymmetric single-walled carbon nanotube/iron oxide nanoparticle complexes . Nano, Lett. , 7 : 861
  • Duryea , J. , Magalnick , M. , Alli , S. , Yao , L. , Wilson , M. and Goldbach-Mansky , R. 2008 . Semiautomated three-dimensional segmentation software to quantify carpal bone volume changes on wrist CT scans for arthritis assessment . Med. Phys. , 35 : 2321
  • Kim , K. , Jeong , C. G. and Hollister , S. J. 2008 . Non-invasive monitoring of tissue scaffold degradation using ultrasound elasticity imaging . Acta. Biomaterialia. , 4 : 783
  • Yang , J. , Lim , E. K. , Lee , H. J. , Park , J. , Lee , S. C. , Lee , K. Yoon , H. G. 2008 . Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection . Biomaterials , 29 : 2548
  • Zhang , Q. , Liu , Z. , Carney , P. R. , Yuan , Z. , Chen , H. , Roper , S. N. and Jiang , H. 2008 . Non-invasive imaging of epileptic seizures in vivo using photoacoustic tomography . Phys. Med. Biol. , 53 : 1921

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