Ochratoxin A: The Continuing Enigma

REFERENCES

• Bhatnagar D., Kenneth J. W., Ehrlich K. C. Toxins of filamentous fungi. Fungal allergyand pathogenicity, M. Breitenbach, R. Crameri, S. B. Lehrer. Karger, Basel 2002; Vol. 81: 167
   Google Scholar
• Stormer F. C. Does ochratoxin A prevent iron uptake in bacteria?. 7th Nordic Mycotoxin Meeting. OsloNorway 1995; O24
   Google Scholar
• Stormer F. C., Hoiby E. A. Citrinin, ochratoxin A and iron. Possible implications for their biological function and induction of nephropathy. Mycopathologia 1996; 134: 103, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• IARC. Ochratoxin A. Some naturally occurring substances: Food items and constituents, heterocyclic aromatic amines and mycotoxins, IARC and WHO. IARC, WHO, Lyon 1993; Vol. 56: 489
   Google Scholar
• Park D. L., Troxell T. C. U.S. perspective on mycotoxin regulatory issues. Mycotoxins and food safety, J. W. DeVries, M. W. Trucksess, L. B. Jackson. Kluwer Academic/Plenum, Summit-Arga 2002; Vol. 504: 277
   Google Scholar
• JEFCA. Evaluation of certain food additives and contaminants, Joint FAO/WHO Expert Committee on food additives. 1995; 35
   Google Scholar
• European Commission. Assessment of dietary intake of ochratoxin A by the population of EU member states. Reports of Task Force on Scientific Co-operation. 1997
   Google Scholar
• CCFAC (2001). Draft code for the prevention of mycotoxin contamination in cereals. Food and Agriculture Organization of the United Nations (www.fao.org/docrep/meeting/005/y0474e/y0474e0w.htm)
   Google Scholar
• Viglione P. Contamination of red wine with ochratoxin A (Elintarvikevirasto jyräsi salailevan Alkon). Ilta-Sanomat. Abo-Turku 1998; A8
   Google Scholar
• Claiborne Ray C. Peanut perils?. New York Times, 15.05.2001, late edition. New York 2001; 2
   Google Scholar
• Mrasek V. Zu viel Pilzgifte in Pasta und Polenta (Too many mycotoxins in pasta and polenta). Frankfurter Rundschau. 2002, 29.10.2002, Frankfurt am Main
   Google Scholar
• Bassen B., Brunn W. Ochratoxin A in Paprikapulver (Ochratoxin in paprika powder). Deutsche lebensmittel-Rundschau 1999; 95(4)142
   Google Scholar
• Spiegel, D. (2001). Pilzgift im Lakritz (Mycotoxin in liquorisch), Spiegel Online (www.spiegel.de/spiegel/vorab/0,1518,111022,00.html)
   Google Scholar
• Warentest S. Leichter Nachgeschmack—Schimmelpilzgift in löslichen Kaffee (Slight aftertaste—Mycotoxins in instant coffee powder), in. Test 2001; 8: 82
   Google Scholar
• Leong, S.L. (2003). Wine woman and song (http://www.theasm.com.au/nsw)
   Google Scholar
• Marquardt R. R., Frohlich A. Ochratoxin a: An important western Canadian storage mycotoxin. Can. J. Physiol. Pharmacol. 1990; 68: 991, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Frisvad J. C., Samson R. A. Mycotoxins produced in species of Penicillium and Aspergillus occurring in cereals. Cereal grain mycotoxins, Fungi and quality in drying and storage, J. Chelkowsik. Elsivier, Amsterdam 1991; 441
   Google Scholar
• Schuster E., Dunn-Coleman N., Frisvad J. C., Van Dijck P. W. On the safety of. Aspergillus niger—A review, Applied Microbial Biotechnology 2002; 59(4–5)426
   PubMed Web of Science ®Google Scholar
• Scott P. M., Van Walbeck W., Kennedy B., Anyeti D. Mycotoxins (ochratoxin A, citrinin and sterigmatocystin) and toxigenic fungi in grains and agricultural products. J. Agric. Food Chem. 1972; 20: 1103, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Abramson D., Mills J. T., Sinha R. N. Mycotoxin production in amber durum wheat stored at 15 and 19% moisture content. Food Additives and Contaminants 1990; 7(5)617, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Ramos A. J., Labernia N., Marin S., Sanchis V., Magan N. Effect of water activity and temperature on growth and ochratoxin production by three strains of Aspergillus ochraceus on an barley extract medium and on barley grains. Int. J. Food Microbiol 1998; 44(1–2)133, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Berry L. The pathology of mycotoxins. Journal of Pathology 1988; 154: 301, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Puntaric D., Bosnir J., Smit Z., Baklaic Z. Ochratoxin A in corn and wheat: Geographical association with endemic nephropathy. Croatian Medical Journal 2001; 42(2)175, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Majerus P., Otteneder H. Nachweis und vorkommen on Ochratoxin A in Wein und Traubensaft. Deutsche Lebensmittel-Rundschau 1996; 92(12)388
   Google Scholar
• van der Merwe K. J., Steyn P. S., Fourie L., Scott D. B., Theron J. J. Ochratoxin A, a toxic metabolite produced by Aspergillus ochraceus Wilh. Nature 1965; 205(4976)1112, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• van der Merwe K. J., Steyn P. S., Fourie L., Mycotoxins. Part II. The constitution of ochratoxin A, B, and C, metabolites of Aspergillus ochraceus Wilh. Journal of the Chemical Society, 7038: 1965
   Google Scholar
• Li S., Marquardt R. R., Frohlich A. A., Vitti T. G., Crow G. Pharmacokinetics of ochratoxin A and its metabolites in rats. Toxicology and Applied Pharmacology 1997; 145: 82, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Müller G., Rosner H., Rohrmann B., Erler W., Geschwend G., Grafe U., Burkert B., Moller U., Diller R., Sachse K. Effects of the mycotoxin ochratoxin A and some of its metabolites on the human cell line THP-1. Toxicology 2003; 184(1)69, [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Hagelberg S., Hult K., Fuchs R. Toxicokinetics of ochratoxin A in several species and its plasma-binding properties. Journal of Applied Toxicology 1989; 9(2)91, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Galtier P., Alvinerie M., Charpenteau J. L. The Pharmacokinetic profiles of ochratoxin A in pigs, rabbits and chickens. Food and Cosmetics Toxicology 1981; 19: 735, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Mortensen H. P., Hald B., Madsen A. Feeding experiments with ochratoxin A contaminated barley for bacon pigs: 5. Ochratoxin A in pig blood. Acta Agriculturae Scandinavica 1983; 33: 235
   Web of Science ®Google Scholar
• Ballinger M. B., Phillips T. D., Kubena L. F. Assessment of the distribution and elimination of ochratoxin a in the pregnant rat. Journal of Food Safety 1986; 8: 11, [CSA]
   Web of Science ®Google Scholar
• Galtier P., Charpenteau J.-L., Alvinerie M., Labouche C. The pharmacokinetic profile of ochratoxin A in the rat after oral and intravenous administration. Drug Metabolism and Disposition 1979; 7(6)429, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Fukui Y., Hoshino K., Kameyama Y., Yasui T., Toda C., Nagano H. Placental transfer of ochratoxin A and its cytotoxic effect on the mouse embryonic brain. Food and Chemical Toxicology 1987; 25: 17, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• JEFCA. Ochratoxin A, Joint FAO/WHO Expert Committee on food additives. 2001; 10
   Google Scholar
• Peraica, M., Radic, B., Lucic, A., Pavlovic, M. Diseases caused by molds in humans. 1999; vol. 2003. Health and Energy.
   Google Scholar
• Krogh P., Elling F., Gyrd-Hansen N., Hald B., Larsen A. E., Lillehoj E. B., Madsen A., Mortensen H. P., Ravnskov U. Experimental porcine nephropathy: Changes of renal function and structure perorally induced by crystalline ochratoxin A. Acta Pathologica Microbiologica Scandinavica Section A 1976; 84: 429
   Google Scholar
• Stoev S. D., Stoeva J. K., Anguelov G., Hald B., Creppy E. E., Radic B. Haematological, biochemical and toxicological investigations in spontaneous cases with different frequency of porcine nephropathy in Bulgaria. Zentralbl. Veterinarmed. A 1998; 45(4)229, [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Marquardt R. R., Frohlich A. A. A review of recent advances in understanding ochratoxicosis. Journal of Animal Science 1992; 70: 3968, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Danilovic V., Djurisic M., Stojimirovic B., Zivojinovic J., Stojakovic P. Nephrites chronique provoquees par l'intoxication au plomb par voie digestive (farine). Presse Med. 1957; 65: 2039, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Tatu C. A., Orem W. H., R.B. F., Feder G. L. The etiology of Balkan endemic nephropathy: Still more questions than answers. Environmental Health Perspectives 1998; 106(11)689, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Djukanovic L., Radovic M., Bakovic J., Budosan I., Bukvic D., Cveticanin A., Davinic S., Dragoljic B., Djordjevic V., Djuric S., Haviza-Lilic M., Janos B., Jelacic S., Kostic N., Mandic M., Ostric V., Pljesa S., Radisic M., Radojevic M., Rakic N., Rangelov V., Stojanovic M., Tintor D., Vasic V. Epidemiology of end-stage renal disease and current status of hemodialysis in Yugoslavia. Int. J. Artif. Organs 2002; 25(9)852, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Vukelic M., Sostaric B., Fuchs R. Some pathomorphological features of Balkan endemic nephropathy in Croatia. Mycotoxins, endemic nephropathy and urinary tract tumours, M. Castegarno, R. Plestina, G. Dirheimer, I. N. Chernozemsky, H. Bartsch. IARC Scientific, Lyons 1991; vol. 115: 37
   Google Scholar
• Sostaric B., Vukelic M. Characteristics of urinary tract tumours in the area of Balkan endemic nephropathy in Croatia. Mycotoxins, endemic nephropathy and urinary tract tumours, M. Castegnaro, R. Plestina, G. Dirheimer, I. N. Chernozemsky, H. Bartsch. IARC Scientific, Lyons 1991; vol. 115: 29
   Google Scholar
• Abdelhamid A. M. Occurrence of some mycotoxins (aflatoxin, ochratoxin A, citrinin, zearalenon and vomitoxin) in variours Egyptian feeds. Archive in Animal Nutrition 1990; 40(7)647, [CSA]
   Web of Science ®Google Scholar
• Maaroufi K., Achour A., Hammami M., el May M., Betheder A. M., Ellouz F., Creppy E. E., Bacha H. Ochratoxin A in human blood in relation to nephropathy in Tunisia. Hum. Exp. Toxicol. 1995; 14: 609, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Maaroufi K., Achour A., Betbeder A.-M., Hammami M., Ellouz F., Creppy E. E., Bacha H. Foodstuffs and human blood contamination by the mycotoxin ochratoxin A: Correlation with chronic interstitial nephropathy in Tunisia. Arch. Toxicol. 1995; 69: 552, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Radic B., Fuchs R., Peraica M., Lucic A. Ochratoxin A in human sera in the area with endemic nephropathy in Croatia. Toxicology Letters 1997; 91: 105, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Fillastre J.-P. Néphrotoxicité expérimentale et humaine des ochratoxines. Bull. Acad. Natl. Méd 1997; 181(7)1447, [CSA]
   PubMedGoogle Scholar
• Kuiper-Goodmann T. Approaches to the risk analysis of mycotoxins in the food supply. Food, Nutrition and Agriculture 1999; 23: 10, [CSA]
   Google Scholar
• Stoev S. D., Hald B., Mantle P. G. Porcine nephropathy in Bulgaria: A progressive syndrome of complex or uncertain (mycotoxin) aetiology. Vet. Rec 1998; 142(8)190, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Elling F. Ochratoxin A-induced mycotoxic porcine nephropathy: Alterations in enzyme activity in tubular cells. Acta Pathologica Microbiologica Scandinavica Sect. A 1979; 87A(4)237
   PubMedGoogle Scholar
• Elling F. Feeding experiments with ochratoxin A-contaminated barley to bacon pigs. Acta Agric Scand 1983; 33: 153
   Google Scholar
• Boorman g. A., McDonald M.R., Imoto S., Persing R. Renal lesions induced by ochratoxin A exposure in the F344 rat. Toxicologic Pathology 1992; 20(2)236, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Bendele A. M., Carlton W. W., Krogh E. B., Lillehoj E. B. Ochratoxin A carcinogenesis in the (C57BL/&J X C*H)F1 mouse. Journal of the National Cancer Institute 1985; 75(4)733, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Appelgren L.-E., Arora R. G. Distribution of 14C-labelled ochratoxinA in pregnant mice. Food Chem. Toxicol. 1983; 21(5)563, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Fuchs R., Appelgren L.-E., Hult K. Distribution of 14C-Ochratoxin A in the mouse monitored by whole-body autoradiography. Pharmacol. Toxicol. 1988; 63: 355, [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Fuchs R., Hult K. Ochratoxin A in blood and its pharmacokinetic properties. Food Chem. Toxic. 1992; 30(3)201, [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• DFG. Ochratoxin A, Vorkommen und toxikologische Bewertung. Deutsche Forschungsgemeinschaft. 1990
   Google Scholar
• Studer-Rohr J., Schlatter J., Dietrich D. R. Intraindividual variation in plasma levels and kinetic parameters of ochratoxin A in humans. Arch. Toxicol. 2000; 74(9)499, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Curtui V. G., Gareis M., Usleber E., Martlbauer E. Survey of Romanian slaughterd pigs for the occurrence of mycotoxins A and B, and zearalenone. Food Addit. Contam. 2001; 18(8)730, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Stoev S. D., Paskalev M., MacDonald S., Mantle P. G. Experimental one year ochratoxicosis in pigs. Experimental and Toxicological Pathology 2002; 53: 481, [CSA]
   PubMed Web of Science ®Google Scholar
• Özcelik N., Kosar A., Soysal D. Ochratoxin in human serum samples collected in Isparta, Turkey, from healthy individuals and individuals suffering from different urinary disorders. Toxicol. Lett. 2001; 121(1)9, [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Filali A., Betbeder A.-M., Baudrimont I., Benyad A., Soulaymani R. Ochratoxin A in human plasma in Morocco: A preliminary survey. Hum. Exp. Toxicol. 2002; 21(5)241, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Abid S., Hassen W., Achour A., Skhiri H., Ellouz F., Creppy E. E., Bacha H. Ochratoxin A and human chronic nephropathy in Tunisia: Is the situation endemic?. Hum. Exp. Toxicol. 2003; 22(2)77, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Peraica M., Domijan A. M., Fuchs R., Lucic A., Radic B. The occurrence of ochratoxin A in blood in general population of Croatia. Toxicol. Lett. 1999; 110: 105, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Nikolov I. G., Petkova-Bocharova D., Castegnaro M., Pfohl-Leskowicz A., Gill C., Day N., Chernozemsky I. N. Molecular and epidemiological approaches to the etiology of urinary tract tumors in an area with Balkan endemic nephropathy. J. Environ. Pathol. Toxicol. Oncol. 1996; 15(2–4)201, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Galtier P. Contribution of pharmacokinetic studies to mycotoxicology—Ochratoxin A. Veterinary Science Communications 1978; 1: 349, [CSA]
   Google Scholar
• Hult K., Fuchs F. Analysis and dynamics of ochratoxin A in biological systems. Mycotoxins and Phycotoxins, P. S. Steyn, R. Vleggaar. Elsevier Science, Amsterdam 1986; 365
   Google Scholar
• Kumagai S. Ochratoxin A: Plasma concentration and excretion into bile and urine in albumin-deficient rats. Food Chem. Toxicol. 1985; 23(10)941, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Kumagai S., Aibara K. Intestinal absorption and secretion of ochratoxin A in the rat. Toxicology and Applied Pharmacology 1982; 64: 94, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Kuiper-Goodman T., Scott P. M. Risk assessment of the mycotoxin ochratoxin A. Biomedical and Environmental Sciences 1989; 2(3)179, [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Sreemannarayana O., Frohlich A. A., Vitti T. G., Maryuardt R. R., Abramson D. Studies of the tolerance and disposition of ochratoxin A in young calves. Journal of Animal Science 1988; 66: 1703, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Roth A., Chakor K., Creppy E. E., Kane A., Röschenthaler R., Dirheimer G. Evidence for an enterohepatic circulation of ochratoxin A in mice. Toxicology 1988; 48: 293, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Fuchs R., Radic B., Paraica M., Hult K., Plestina R. Enterohepatic circulation of ochratoxin A in rats. Period. Biol. 1988; 90(1)39
   Google Scholar
• Stein A. F., Phillips T. D., Kubena L. F., Harvey R. B. Renal tubular secretion and readsorption as factors in ochratoxicosis: Effects of probenicid on nephrotoxicity. J. Toxicol. Environ. Health 1985; 16: 593, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Albassam M. A., Yong S. I., Bhatnagar R., Sharma A. K., Prior M. G. Histological and electron microscopic studies on the acute toxicity of ochratoxin A in rats. Vet. Pathol. 1987; 24: 427, [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Störmer F. C., Hansen C. E., Pedersen J. I., Hvistendahl G., Aasen A. J. Formation of (4R)- and (4S)-4-hydroxyochratoxin A from ochratoxin A by liver microsomes from various species. Appl. Environ. Microbiol. 1981; 42(6)1051
   PubMedGoogle Scholar
• Pitout M. J. The hydrolysis of ochratoxin A by some proteolytic enzymes. Biochemical Pharmacology 1969; 18: 485, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Hansen C. E., Dueland S., Drevon C. A., Stormer F. C. Metabolism of ochratoxin A by primary cultures of rat hepatocytes. Appl. Environm. Microbiol. 1982; 43(6)1267
   PubMedGoogle Scholar
• Stören O., Holm H., Störmer F. C. Metabolism of ochratoxin A by rats. Applied and Environmental Microbiology 1982; 44(4)785, [CSA]
   PubMedGoogle Scholar
• Moroi K., Suzuki S., Kuga T., Yamazaki M., Kanisawa M. Induction of ochratoxin A toxicity in mice treated with phenylalanine and phenolbarbital. Toxicology Letters 1985; 25: 1, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Stander M. A., Nieuwouldt T. W., Steyn P. S., Shepard G. S., Creppy E. E., Sewram V. Toxicokinetics of ochratoxin A in vervet monkeys (Chercopithecus aethiops). Arch. Toxicol. 2001; 75: 262, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMedGoogle Scholar
• Vedani A., Bruinink A. Ochratoxin A und B: Ein dreidimensionales molekulares Modell zur mechanistischen Erklärung ihrer Toxizität (Ochratoxin A and B: A three-dimensional molecular model for a mechanistic explanation of their toxicity). ALTEX 1996; 13(3)124, [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Heussner A. H., O'Brien E., Dietrich D. R. Species- and sex-specific variations in binding of ochratoxin A by renal proteins. in vitro Exp. Toxicol. Pathol. 2002; 54: 151
   PubMedGoogle Scholar
• Tsuda M., Sekine T., Takeda M., Cha S. H., Kanai Y., Kimura M., Endou H. Transport of ochratoxin A by renal multispecific organic anion transporter 1. Journal of Pharmacology and Experimental Therapeutics 1999; 289: 1301, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Il'ichev Y. V., Perry J. L., Rüker F., Dockal M., Simon J. D. Interaction of ochratoxin A with human binding sites localized by competitive interactions with native protein and its recombinant fragments. Chemico-Biological Interactions 2002; 141: 275, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Russel F. G.M., Masereeuw R., van Aubel R. A.M.H. Molecular aspects of renal anionic drug transport. Annu. Rev. Physiol. 2002; 64: 563, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Masereeuw R., Russel F. G.M. Mechanisms and clinical implications in renal drug excretion. Drug. Metab. Rev., 33(3–4)299, [CSA]
   PubMedGoogle Scholar
• Sokol P. P., Ripich G., Holohan P. D., Ross C. R. Mechanism of ochratoxin A transport in kidney. J. Pharmacol. Exp. Ther. 1988; 246(2)460, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Gekle M., Mildenberger S., Freudinger R., Silbernagel S. The mycotoxin ochratoxin A impairs protein uptake in cells derived from the proximal tubule of the kidney (opossum kidney cells). J. Pharmacol. Exp. Ther. 1994; 271: 1, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Groves C. E., Morales M., Wright S. H. Peritubular transport of ochratoxin A in rabbit renal proximal tubules. Journal of Pharmacology and Experimental Therapeutics 1998; 284(3)943, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• O'Brien E., Heussner A. H., Dietrich D. Species-, sex- and cell type specific effects of ochratoxin A and B. Toxicological Sciences 2001; 63: 256, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Jung K. Y., Takeda M., Kim D. K., Tojo A., Narikawa S., Yoo B. S., Hosoyamada M., Cha S. H., Sekine T., Endou H. Characterization of ochratoxin A transport by human organic anion transporters. Life Sciences 2001; 69: 2123, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Babu E., Takeda M., Narikawa S., Kobayashi Y., Enomoto A., Tojo A., Cha S. H., Sekine T., Sakthisekaran D., Endou H. Role of human anio transporter 4 in the transport of ochratoxin A. Biochimica et Biophysica Acta 2002; 1590: 64, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Buist S. C.N., Klaassen C. D. Species and gender differences inorganic anion transporter (OAT) mRNA. Toxicological Sciences (The Toxicologist) 2003; 72(S-1)259
   Google Scholar
• Buist S. C.N. Gender-specific and developmental influences on the expression of rat organic anion transporters. Journal of pharmacology and experimental therapeutics 2002; 301: 145, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Dreger S., O'Brien E., Satck M., Dietrich D. Antiproliferative effects and cell-cycle specific effects of ochratoxin A in LLC-PK1, NRK-52E and porcine primary proximal kidney cells. Toxicological Sciences 2000; 54(1)170
   Google Scholar
• Obrecht-Pflumio S., Chassat T., Dirheimer G., Marzin D. Genotoxicity of ochratoxin A by Salmonella mutagenicity test after bioactivation by mouse kidney microsomes. Mutat. Res. 1999; 446(1)95, [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Föllmann W., Lucas S. Effects of ochratoxin A in a bacterial and a mammalian in vitro mutagenicity test system. Archives in toxicology 2003; 77: 298
   PubMed Web of Science ®Google Scholar
• Föllmann W., Hillebrand I. E., Creppy E. E., Bolt H. M. Sister chromatid exchange frequency in cultured isolated porcine urinary bladder epithelial cells (PUBEC) treated with ochratoxin A and alpha. Arch. Toxicol. 1995; 69: 280, [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Doerrenhaus A., Flieger A., Golka K., Schulze H., Albrecht M., Degen G. H., Follman W. Induction of unscheduled DNA synthesis in primary human urothelial cells by the mycotoxin ochratoxin A. Toxicological Sciences 2000; 53: 271, [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Rahimtula A. D., Bereziat J. C., Bussacchini G. V., Bartsch H. Lipid peroxidation as a possible cause of ochratoxin A toxicity. Biochemical Pharmacology 1988; 37(23)4469, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Schwerdt G., Freudinger R., Mildenberger S., Silbernagl S., Gekle M. The nephrotoxin ochratoxin A induces apoptosis in cultured human proximal tubule cells. Cell Biology and Toxicology 1999; 15(6)405, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Horvath A., Upham B. L., Ganev V., Trosko J. E. Determination of the epigenetic effects of ochratoxin in a human kidney and a rat liver epithelial cell line. Toxicon 2002; 40: 273, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Degen G. H. Induction of micronuclei with ochratoxin A in ovine seminal vesicle cell cultures. Archives in Toxicology 1997; 71: 365, [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Dopp E., Muller J., Hahnel C., Schiffmann D. Induction of genotoxic effects and modulation of the intracellular calcium level in Syrian hamster embryo (SHE) fibroblasts caused by ochratoxin A. Food and Chemical Toxicology 1999; 37(7)713, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Cooray R., Kiessling K. H., Lindahl-Kiessling K. The effects of patulin and patulin-cystein mixtures on DNA synthesis and the frequency of sister-chromatid exchanges in human lymphocytes. Food Chem. Toxicol. 1982; 20: 893, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Bendele A. M., Neal S. B., Oberly T. J., Thompson C. Z., Bewsey B. J., Hill L. E., Rexroat M. A., Carlton W. W., Probst G. S. Evaluation of ochratoxin A for mutagenicity in a battery of bacterial and mammalian cell assays. Food Chem. Toxicol. 1985; 23: 911, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Donmez-Altuntas H., Hamurcu Z., Imamoglu N., Liman B. C. Effects of ochratoxin A on micronucleus frequency in human lymphocytes. Nahrung 2003; 47(1)33, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Ehrlich V., Darroudi F., Uhl M., Steinkellner H., Gann M., Majer B. J., Eisenbauer M., Knasmüller S. Genotoxic effects of ochratoxin A in human-derived hepatoma (HepG2) cells. Food and Chemical Toxicology 2002; 40: 1085, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Fuchs R., Radic B., Ceovic S., Sostaric B., Hult K. Human exposure to ochratoxin A. Mycotoxins, endemic nephropathy and urinary tract tumours, M. Castegnaro, R. Plestina, G. Dirheimer, I. N. Chernozemsky, H. Bartsch. International Agency for Research on Cancer, Lyon 1991; vol. 115: 131
   Google Scholar
• Palli D., Miraglia M., Saieva C., Masala G., Cava E., Colatosti M., Corsi A. M., Russo A., Brera C. Serum levels of of OTA in healthy adults in Tuscany: Correlation with individual characteristics and between repeat measurements. Cancer Epidemiology. Biomarkers and Prevention 1999; 8: 265, [CSA]
   PubMed Web of Science ®Google Scholar
• Gross-Steinmeyer K., Weymann J., Hege H.-G., Metzler M. Metabolism and lack of DNA reactivity of the mycotoxin ochratoxin A in cultured rat and human primary hepatocytes. Journal of Agricultural and Food Chemistry 2002; 50: 938, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Zepnik H., Pahler A., Schauer U., Dekant W. Ochratoxin A-induced tumor formation: Is there a role of reactive ochratoxin A metabolites?. Toxicol. Sci. 2001; 59(1)59, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Gautier J., Richoz J., Welti D. H., Markovic J., Gremaud E., Guengerich F. P., Turesky R. J. Metabolism of ochratoxin A: Absence of formation of genotoxic derivatives by human and rat enzymes. Chem. Res. Toxicol. 2001; 14(1)34, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Creppy E. E., Kane A., Dirheimer G., Lafarge-Frayssinet C., Mousset S., Frayssinet C. Genotoxicity of ochratoxin A in mice: DNA single-strand break evaluation in spleen, liver and kidney. Toxicology Letters 1985; 28: 29, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Pfohl-Leszkowicz A., Chakor K., Creppy E. E., Dirheimer G. DNA adduct formation in mice treated with ochratoxin A. Mycotoxins, endemic nephropathy and urinary tract tumours, M. Castegnaro, R. Plestina, G. Dirheimer, I. N. Chernozemsky, H. Bartsch. International Agency for Research on Cancer, Lyon 1991; vol. 115: 245
   Google Scholar
• Pfohl-Leszkowicz A., Grosse Y., Kane A., Creppy E. E., Dirheimer G. Differential DNA adduct formation and disappearance in three mouse tissues after treatment with the mycotoxin ochratoxin A. Mutation Research 1993; 289: 265, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Castegnaro M., Mohr U., Pfohl-Leszkowicz A., Esteve J., Steinmann J., Tillman T., Michelon J., Bartsch H. Sex- and strain-specific induction of renal tumours by ochratoxin A in rats correlates with DNA adduction. Int. J. Cancer 1998; 77(1)70, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Obecht-Pflumio S., Dirheimer G. Horseradish peroxidase mediates DNA and deoxyguanosine 3′-monophosphate adduct formation in the presence of ochratoxin A. Archives of Toxicology. 2001
   Google Scholar
• Gautier J.-C., Holzhaeuser D., Markovic J., Gremaud E., Schilter B., Turesky R. J. Oxidative damage and stress response from ochratoxin A exosure in rats. Free Radical Biology & Medicine 2001; 30(10)1089, [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Dai J., Wright M. W., Manderville R. A. Ochratoxin forms a carbon-bonded C8-deoxyguanosine nucleoside adduct: Implications for C8 reactivity by a phenolic radical. Journal of the American Chemical Society 2003; 125: 3715
   Google Scholar
• Gillman I. G., Clark T. N., Manderville R. A. Oxidation of ochratoxin A by an Fe-porphyrin system: Model for enzymatic activation and DNA cleavage. Chemical Research in Toxicology 1999; 12: 1066, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Dai J., Park G., Wright M. W., Adams M., Akman S. A., Manderville R. A. Detection and characterization of a glutathione conjugate of ochratoxin A. Chemical Research in Toxicology 2002; 15: 1581, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Creppy E. E., Lugnier A. A.J., Beck G., Röschenthaler R., Dirheimer G. Action of ochratoxin A on cultured hepatoma cells—Reversion of inhibition by phenylalanine. FEBS Letters 1979; 104(2)287, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMedGoogle Scholar
• Creppy E. E., Lugnier A. A.J., Fasiolo f., Heller K., Röschenthaler R., Dirheimer G. In vitro inhibition of yeast phenylalanyl-tRNA synthetase by ochratoxin A. Chemico-Biological Interactions 1979; 24: 257, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Omar R. F., Hasinoff B. B., Mejilla F., Rahimtula A. D. Mechanism of ochratoxin a stimulated lipid peroxidation. Biochemical Pharmacology 1990; 40(6)1183, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Omar R. F., Rahimtula A. D. Role of cytochrom P-450 in ochratoxin A-stimulated lipid peroxidarion. J. Biochem. Toxicology 1991; 6(3)203
   PubMedGoogle Scholar
• Heussner A., Schwöbel F., Dietrich D. R. Cytotoxicity of ochratoxin A and B in vitro: Comparison of male and female rat primary renal cortex and distal cells and LLC-PK1 cells. Toxicological Sciences 1998; 42: 1416
   Google Scholar
• Petrik J., Zanic-Grubisic T., Barisic K., Pepeljnjak S., Radic B., Ferencic Z., Cepelak I. Apoptosis and oxidative stress induced by ochratoxin A in rat kidney. Archives in Toxicology 2003; 77: 685, [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Omar R. F., Hasinoff B. B., Mejilla F., Rahimtula A. D. Mechanism of ochratoxin A stimulated lipid peroxidation. Biochemical Pharmacology 1990; 40(6)1183, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Meki A. R.M.A., Hussein A. A.A. Melatonin reduces oxidative stress induced by ochratoxin A in rat liver and kidney. Comparative Biochemistry and Physiology Part C 2001; 130: 305, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Schaaf G. J., Nujmeijer S. M., Maas R. F.M., Roestenberg P., De Groene E. M., Fink-Gremmels J. The role of oxidative stress in the ochratoxin A-mediated toxicity in proximal tubular cells. Biochimica et Biophysica Acta 2002; 1588: 149, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Hoehler D., Marquardt R. R. Influence of vitamins E and C on the toxic effects of ochratoxin a and T-2 toxin in chicks. Poultry Science 1996; 75: 1508, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Hoehler D., Marquardt R. R., McIntosh A. R., Xiao H. Free radical generation as induced by ochratoxin A and its analogs in bacteria (Bacillus brevis). Journal of Biological Chemistry 1996; 271(44)27388, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMedGoogle Scholar
• Hoehler D., Marquardt R. R., McIntosh A. R., Hatch G. M. Induction of free radicals in hepatocytes, mitochondria and microsomes of rats by ochratoxin A and its analogs. Biochimica et Biophysica Acta 1997; 1357: 225, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Obrecht-Pflumio S., Grosse Y., Pfohl-Leszkowicz A., Dirheimer G. Protection by indomethacin and aspirin against genotoxicity of ochratoxin A, particularly in the urinary bladder and kidney. Arch. Toxicol. 1996; 70(3–4)244, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMedGoogle Scholar
• Grosse Y., Chekir-Ghedira L., Huc A., Obrecht-Pflumio S., Dirheimer G., Bacha H., Pfohl-Leszkowicz A. Retinol, ascorbic acid and alpha-tocopherol prevent DNA adduct formation in mice treated with the mycotoxins ochratoxin A and zearalenone. Cancer Lett. 1997; 114(1–2)225, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Santin E., Paulillio A. C., Maiorka P. C., Alessi A. C., Krabbe E. L., Maiorka A. The effects of ochratoxin/aluminosilicate interaction on the tissues and humoral response of broilers. Avian Pathology 2002; 31: 73, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Moore J. H., Truelove B. Ochratoxin A: Inhibition of mitochondrial respiration. Science 1970; 168: 1102, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Meisner H., Chan S. Ochratoxin A, an inhibitor of mitochondrial transport system. Biochemistry 1974; 13(14)2795, [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Wei Y.-H., Lu C.-Y., Lin T.-N., Wei R.-D. Effect of ochratoxin A on rat liver mitochondrial respiration and oxidative phosphorylation. Toxicology 1985; 36: 119, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Eder S., Benesic A., Freudinger R., Engert J., Schwerdt G., Drumm K., Gekle M. Nephritogenic ochratoxin A interfers with mitochondrial function and pH homeostasis in immortalized human kidney epithelial cells. Pflügers Arch. Eur. J. Physiol. 2000, online, published DOI 10.1007/s004240000321
   PubMedGoogle Scholar
• Heller M., Rosner H., Burkert B., Moller U., Hinsching A., Rohrmann B., Thierbach S., Kohler H. In vitro studies into the influence of ochratoxin A on the production of tumor necrosis factor alpha by the human monocytic cell line THP-1. Deutsche Tierarztliche Wochenschrift 2002; 109(4)200, [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Luhe A., Hildebrand H., Bach U., Dingerman T., Ahr H.-J. A new approach to studying ochratoxin A (OTA)-induced nephrotoxicity: Expression profiling in vivo and in vitro employing cDNA microarrays. Toxicological Sciences 2003; 73: 315, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Gekle M., Schwerdt G., Freudinger R., Mildenberger S., Wilflingseder D., Pollack V., Dander M., Schramek H. Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. Journal of Pharmacology and Experimental Therapeutics 2000; 293(3)837, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Gennari A., Boveri M., Pazos P., Callaghan R., Casado J., Prieto P. Cellular and molecular mechanisms underlying ochratoxin A-induced. in vitro nephrotoxicity, Toxicological Sciences (The Toxicologist) 2003; 72(S-1)348, [CSA]
   Google Scholar
• Assaf H., Azouri H., Pallardy M. Mechanisms of ochratoxin A-induced inhibition of human lymphocyte proliferation. Toxicological Sciences (The Toxicologist) 2003; 72(S-1)358, [CSA]
   Google Scholar
• Seegers J. C. A comparative study of ochratoxin A-induced apoptosis in hamster kidney and HeLa cells. Toxicology and Applied Pharmacology 1994; 129: 1, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Wolf P., O'Brien E., Heussner A. H., Stack M. E., Thiel R., Dietrich D. R. Sex- and age-specific effects of ochratoxin A in primary human kidney cells (HKC). Toxicological Sciences 2002; 66(1-S)400
   Google Scholar
• Heussner A., Stack M., Hochberg K., Dietrich D. Comparison of cytotoxic effects of ochratoxin A and B on human, rat and porcine renal cells. Toxicological Sciences 2000; 54(1)170
   Google Scholar
• Rásonyi T., Schlatter J., Dietrich D. R. The role of α2μ-globulin in ochratoxin A induced renal toxicity and tumors in F344 rats. Toxicology Letters 1999; 104: 83, [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Gekle M., Oberleithner H., Silbernagl S. Ochratoxin A impairs “postproximal” nephron function in vivo and blocks plasma membrane anion conductance in Madin-Darby canine kidney cells in vitro. Pflügers Archiv European Journal of Physiology 1993; 425: 401, [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Barisic K., Petrick J., Rumora L., Cepelak I., Zanic Grubisic T. Expression of Hsp70 in kidney cells exposed to ochratoxin A. Molecular Toxicology 2002; 76: 218
   Google Scholar
• Harvey R. B., Elissalde M. H., Kubena L. F., Weaver E. A., Corrier D. E. Immunotoxicity of ochratoxin A to growing gilts. American Journal of Veterinary Research 1992; 53(10)1966, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Holmberg T., Thuvander A., Hult K. Ochratoxin A as a suppressor of mitogen-induced blastogenesis of porcine blood lymphocytes. Acta Vet. Scandinavica 1988; 29: 219
   PubMed Web of Science ®Google Scholar
• Müller G., Kielstein P., Rosner H., Berndt A., Heller M., Kohler H. Studies of the influence of ochratoxin A on immune and defence reactions in weaners. Mycoses 1999; 42(7–8)495, [CSA]
   PubMedGoogle Scholar
• Verma R. J., Mathew S. Alterations in total and differential counts of WBC during ochratoxicosis in rabbits. Indian Journal of Experimental Biology 1998; 36: 424, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Müller G., Kielstein P., Köhler H., Berndt A., Rosner H. Studies on the influence of ochratoxin A on immune and defence reactions in the mouse model. Mycoses 1995; 38: 85, [CSA]
   PubMed Web of Science ®Google Scholar
• Prior M. G., Sisodia C. S. The effects of ochratoxin A on the immune system in Swiss mice. Can. J. Comp. Med. 1982; 46: 91, [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Haubeck H.-D., Lorkowski G., Koelsch E., Roeschenthaler R. Immunosuppression by ochratoxin A and its prevention by phenylalanine. Appl. Environm. Microbiol. 1981; 41(4)1040, [CSA]
   PubMedGoogle Scholar
• Creppy E. E., Stormer F. C., Roeschenthaler R., Dirheimer G. Effects of two metabolites of ochratoxin A, (4R)-4-hydroxyochratoxin A and ochratoxin alpha, on immune response in mice. Infection and Immunity 1983; 39(3)1015, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Jordan W. H., Carlton W. W. Citrinin mycotoxicosis in the mouse. Food and Cosmetic Toxicology 1977; 15: 29
   PubMedGoogle Scholar
• Stoev S. D., Goundasheva D., Mirtcheva T., Mantle P. G. Susceptibility to secondary bacterial infections in growing pigs as an early response in ochratoxicosis. Experimental and Toxicological Pathology 2000; 52: 287
   PubMed Web of Science ®Google Scholar
• Stoev S. D., Anguelov G., Pavlov D. Influences of ochratoxin A and an extract of artichoke on the vaccinal immunity and health in broiler chicks. Experimental and Toxicological Pathology 2000; 52: 43
   PubMed Web of Science ®Google Scholar
• Stoev S. D., Koynarsky V., Mantle P. G. Clinicomorphological studies in chicks fed ochratoxin A while simultaneoulsy developing coccidosis. Veterinary research Communications 2002; 26: 189, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Creppy E. E., Kern D., Steyn P. S., Vleggaar R., Röschenthaler R., Dirheimer G. Comparative study on the effect of ochratoxin A analogues on yeast aminoacyl-tRNA synthetases and on the growth and protein synthesis of hepatoma cells. Toxicology Letters 1983; 19: 217, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Dwivedi P. Effect of ochratoxin A on immunoglobulins in broiler chicks. Research in Veterinary Science 1984; 36: 117, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Patterson D. S.P., Shreeve B. J., Roberts B. A. Effect on claves of barley naturally contaminated with ochratoxin A and groundnut meal contaminated with low concentrations of aflatoxin B1. Research in Veterinary Science 1981; 31: 213, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Richard J. L., Thurston J. R., Deyse B. L. Effect of ochratoxin and aflatoxin on serum proteins, complement activity and antibody production to Brucella abortus in guinea pigs. Applied and Environmental Microbiology 1975; 29: 27
   Google Scholar
• Creppy E. E., Stormer C. F., Röschenthaler R. T., Dirheimer G. Effects of two metabolites of ochratoxin A, (4R)-4-hydroxyochratoxin A and ochratoxin alpha, on immune response in mice. Infection and Immunity 1983; 39: 1015, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Charoenpornsook K., Fitzpatrick J. L., Smith J. E. The effects of four mycotoxins on the mitogen stimulated proliferation of bovine peripheral blood mononuclear cells in vitro. Mycopathologia 1998; 143: 105, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Marin M. L., Murtha J., Dong W., Pestka J. J. Effects of mycotoxins on cytokine production and proliferation in EL-4 thyoma cells. Journal of Toxicology and Environmental Health 1996; 48: 379, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Heller M., Köhler H., Rosner H., Burkert B., Rohrmann B., Möller U., Thierbach S., Kielstein P., Müller G. Beeinflussung der Zytokinsekretion von Maus-Thyomzellen (EL-4) durch ochratoxin. Mycotoxin Research 2000; 16A: 194
   Google Scholar
• Lea T., Steien K., Stormer F. C. Mechanism of ochratoxin A-induced immunosuppression. Mycopathologia 1989; 107(2–3)153, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Schwöbel F., O'Brien E., Dietrich D. R., Ochratoxin A. (OTA) reversibly inhibits proliferation in the LLCPK-1 cell line. Toxicol. Sci. 1999
   Google Scholar
• Bruinink A., Rasonyi T., Sidler C. Reduction of ochratoxin A toxicity by heat-induced epimerization. In vitro effects of ochratoxins on embryonic chick meningeal and other cell cultures. Toxicology 1997; 118: 205, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Manolov G., Manolova Y., Castegnaro M., Chernozemsky I. N. Chromosomal alterations in lymphocytes of patients with Balkan endemic nephropathy and of healthy individuals after incubation in vitro with ochratoxin A. Mycotoxins, endemic nephropathy and urinary tract tumours, M. Castegnaro, R. Plestina, G. Dirheimer, I. N. Chernozemsky, H. Bartsch. International Agency for Research on Cancer, Lyon 1991; vol. 115: 267
   Google Scholar
• Hayes A. W., Hood R. D., Lee H. L. Teratogenic effects of ochratoxin A in mice. Teratology 1973; 9: 93
   Google Scholar
• Hayes A. W., Hood R. D., Lee H. L. Teratogenic effects of ochratoxin A in mice. Teratology 1974; 9: 93, [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Hood R. D., Naughton M. J., Hays A. W. Prenatal effects of ochratoxin A in hamsters. Teratology 1976; 13: 11, [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Brown M. H., Szczech G. M., Purmalis B. P. Teratogenic and toxic effects of ochratoxin A in rats. Toxicol. Appl. Pharmacol. 1976; 37: 331, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ehlers K., Sturge H., Merker H. J., Nau H. Spina bifida aperta induced by valproic acid in the mouse: Distinct differences in morphology and periods of sensitivity. Teratology 1992; 48: 117
   Google Scholar
• Krätke R., Rühl R., Kirschbaum F., Nau H. All-trans-retinoic acid and all-trans-retinoyl-b-d-glucuronide alter the development of axolotl embryos (Ambystoma mexicanum) in vitro. Archives in Toxicology 2000; 74: 173, [CROSSREF]
   PubMedGoogle Scholar
• Nowak E. Die sensible Phase bei der Tahlidomide-Embryopathie. Humangenetik 1965; 1: 516, [CROSSREF]
   PubMedGoogle Scholar
• Arora R. G., Frölèn H., Nilsson A. Interference of mycotoxins with prenatal development of the mouse I. Influence of aflatoxin B1, ochratoxin A and zearalenone. Acta Vet. Scand. 1981; 22: 524, [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Mayura K., Parker R., Berndt W. O., Phillips T. D. Ochratoxin A—induced teratogenesis in rats: Partial protection by phenylalanine. Appl. Environm. Microbiol. 1984; 48(6)1186, [CSA]
   PubMedGoogle Scholar
• Arora R. G., Froelein H., Fellner-Feldegg H. Inhibition of ochratoxin A teratogenesis by zearalenone and diethylstilboestrol. Fundamentals in Chemical Toxicology 1983; 21(6)779, [CSA], [CROSSREF]
   Google Scholar
• Shreeve B. J., Patterson S. P., Pepin G. A., Roberts B. A., Wrathall A. E. Effect of feeding ochratoxin to pigs during early pregnancy. British Veterinary Journal 1977; 133: 412, [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Wei X., Sulik K. K. Pathogenesis of craniofacial and body wall malformations induced by ochratoxin A in mice. American Journal of Medical Genetics 1993; 47: 862, [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Wei X., Sulik K. K. Pathogenesis of caudal dysgenesis/sirenomelia induced by ochratoxin A in chick embryos. Teratology 1996; 53: 378, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Abdel-Wahhab M. A., Nada S. A., Arbid M. S. Ochratoxicosis: Prevention of developmental toxicity by l-methionine in rats. Journal of Applied Toxicology 1999; 19(7), [CSA]
   Google Scholar
• Fukui Y., Hayasaka S., Itoh M., Takeuchi Y. Development of neurons and synapses in ochratoxin A-induced microcephalic mice: A quantitative assessment of somatosensory cortex. Neurotoxicology and Teratology 1992; 14: 191, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMedGoogle Scholar
• Hong J. T., Park K. L., Han S. Y., Park K. S., Kim H. S., Oh S. D., Lee R. D., Jang S. J. Effects of ochratoxin A on cytotoxicity and cell differentiation in cultured rat embryonic cells. J. Toxicol. Environ. Health A 2000; 61(7)609, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Monnet-Tschudi F., Sorg O., Honegger P., Zurich M.-G., Huggett A. C., Schilter B. Effects of the naturally occurring food mycotoxin ochratoxin a on brain cells in culture. NeuroToxicology 1997; 18(3)831, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Belmadani A., Tramu G., Betbeder A.-M., Steyn P. S., Creppy E. E. Regional selectivity to ochratoxin A, distribution and cytotoxicity in rat brain. Arch. Toxicol. 1998; 72: 656–662, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Bruinink A., Sidler C. The neurotoxic effects of ochratoxin-A are reduced by protein binding but are not affected by l-phenylalanine. Toxicology and Applied Pharmacology 1997; 146: 173, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Han S. Y., Park K. S., Hong J. T., Kim H. S., Oh S. D., Kook S. S., Jang S. J. Ochratoxin A-induced embryotoxicity and preventive effect of catalase in cultured rat embryonic midbrain cells. Teratology 1998; 59: 403
   Google Scholar
• Hong J. T., Lee M. K., Park K. S., Jung K. M., Lee R. D., Jung H. K., Park K. L., Yang K. H., Chung S. Y. Inhibitory effects of peroxisome proliferator-activated receptor gamma agonist on ochratoxin A-induced cytotoxicity and activation of transcription factors in cultured rat embryonic midbrain cells. Journal of Toxicology and Environmental Health 2002; 65: 407, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Wiger R., Störmer F. C. Effects of ochratoxin A and B on prechondrogenic mensenchymal cells from chick embryo limb buds. Toxicology Letters 1990; 54: 129, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMedGoogle Scholar
• O'Brien E., Prietz A., Dietrich D. R. Characterisation of ochratoxin A uptake and developmental toxicity using the FETAX system. Toxicological Sciences 1999; 43(S1)150
   Google Scholar
• Shlosberg A., Elkin N., Malkinson M., Orgad U., Hanji V., Bogin E., Weisman Y., Meroz M., Bock R. Severe hepatopathy in geese and broilers associated with ochratoxin in their feed. Mycopathologia 1997; 138: 71, [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Peckham J. C., Doupnik B., Jones O. H. Acute toxicity of ochratoxin A and B in chicks. Appl. Microbiol. 1971; 21: 492, [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Atroshi F., Rizzo A., Sankari S., Biese I., Westermarck T., Veijalainen P. Liver and enzyme activities of rats exposed to ochratoxin A and T-2 toxin with antioxidants. Bull. Environ. Contam. Toxicol. 2000; 64: 586, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Biro K., Solzi L., Barna-Vetro I., Bago G., Glavits R., Szabo E., Fink-Gremels J. Tissue distribution of ochratoxin A as determined by HPLC and ELISA and histopatological effects in chickens. Avian Pathology 2002; 31: 141–148, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Wolff J., Bresch H., Cholmakow-Bodechtel C., Engel G., Erhardt S., Gareis M., Majerus P., Rosner H., Scheuer R. Belastung des Verbrauchers und der Lebensmittel mit Ochratoxin A, forschungsverbund Produkt-und Ernährungsforschung des Bundesministeriums für Ernährung. Landwirtschaft und Forsten. 2000; 243
   Google Scholar
• Cihlar T., Lin D. C., Pritchard J. B., Fuller M. D., Mendel D. B., Sweet D. H. The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. Mol. Pharmacol. 1999; 56: 570, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Hosoyamada M., Sekine T., Kanai Y., Endou H. Molecular cloning and functional expression of a multipsecific organic anion transporter from human kidney. Am. J. Physiol. Renal Physiol. 1999; 276: F122
   PubMed Web of Science ®Google Scholar
• Lu R., Chan B. S, Schuster V. L. Cloning of the human kidney PAH transporter: Narrow substrate specificity and regulation by protein kinase C. Am. J. Physiol. Renal Physiol. 1999; 276: F295
   PubMed Web of Science ®Google Scholar
• Kojima, Sekine T. R., Kawachi M., Cha S. H., Suzuki Y., Endou H. Immunolocalization of multispecific organic anion transporters, OAT1, OAT2 and OAT3 in rat kidney. J. Am. Soc. Nephrol. 2002; 13: 848, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Sweet D. H., Wolff N. A., Pritchard J. B. Expression cloning and characterization of ROAT1. The basloateral organic anion transporter in rat kidney. J.Biol. Chem. 1997; 272: 30088, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Sekine T., Watanabe N., Hosoyamada M., Kanai Y., Endou H. Expression cloning and characterization of a novel multispecific anion transporter. J. Biol. Chem. 1997; 272: 18526, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Uwai Y., Okuda M., Takami K., Hashimoto Y., Inui K. I. Functional characterization of the rat multispecific organic anion transporter Oat1 mediating basolateral uptake of anionic drugs in the kidney. FEBS Lett. 1998; 438: 321, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Jariyawat S., Sekine T., Takeda M., Apiwattanakul N., Kanai Y., et al. The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter. J. Pharmacol. Exp. Ther. 1999; 290: 672, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Apiwattanakul N., Sekine T., Chairoungdua A., Kanai Y., Nakajima N., et al. Transport proterties of nonsteroidal anti-inflammatory drugs by organic anion transporter-1 expressed in. Xenopus laevis oocytes. Mol. Pharmacol. 1999; 55: 847, [CSA]
   Google Scholar
• Wada S., Tsuda M., Sekine T., Cha S. H., Kimura M., et al. Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir and other antiviral nucleoside analogs. J. Pharmacol. Exp. Ther. 2000; 294: 844, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Sun W., Wu R. R., van Poelje P. D., Erion M. D. Isolation of a family of organic anion transporters from human liver and kidney. Biochem. Biophys. Res. Commun. 2001; 283: 417, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Sekine T., Cha S. H., Tsuda M., Apiwattanakul N., Nakajima M., et al. Identification of multispecific organic anion transporter expressed predominantly in the liver. FEBS Lett. 1998; 429: 179, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Cha S. H., Sekine T., Fukishima J. I., Kanai Y., Kobayashi Y., et al. Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol. Pharmacol. 2001; 59: 1277, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Takeuchi A., Masuda S., Saito H., Abe T., Inui K. I. Multispecific substrate recognition of kidney-specific organic anion transporters OAT-K1 and OAT-K2. J. Pharmacol. Exp. Ther. 2001; 299: 261, [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Kusuhara H., Sekine T., Utsunomiya-Tata N., Tsuda M., Kojima R., et al. Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J. Biol. Chem. 1999; 274: 13675, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Sweet D. H., Chan L. M., Walden R., Yang X. P., Miller D. S., Pritchard J. B. Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient. Am. J. Physiol. Renal Physiol. 2003; 284: F763, [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Cha S. H., Sekine T., Kusuhara H., Yu E., Kim J. Y., et al. Molecular cloning and characteritation of multispecific organic anion transporter 4 expressed in the placenta. J. Biol. Chem. 2000; 275: 4507, [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar