Mechanisms and Outcomes of Drug- and Toxicant-Induced Liver Toxicity in Diabetes

REFERENCES

• Abdelmegeed M. A., Carruthers N. J., Woodcroft K. J., Kim S. K., Novak R. F. Acetoacetate induces CYP2E1 protein and suppresses CYP2E1 mRNA in primary cultured rat hepatocytes. J. Pharmacol. Exp. Ther. 2005; 315: 203
   PubMed Web of Science ®Google Scholar
• Abbott C. A., Mackness M. I., Kumar S., Olukoga A. O., Gordon C., Arrol S., Bhatnagar D., Boulton A. J., Durrington P. N. Relationship between serum butyrylcholinesterase activity, hypertriglyceridaemia and insulin sensitivity in diabetes mellitus. Clin. Sci. (Lond.) 1993; 85: 77
   PubMed Web of Science ®Google Scholar
• Ackerman D. M., Leibman K. C. Effect of experimental diabetes on drug metabolism in the rat. Drug Metab. Dispos. 1977; 5: 405
   PubMed Web of Science ®Google Scholar
• Akkus I., Kalak S., Vural H., Caglayan O., Menekse E., Can G., Durmus B. Leukocyte lipid peroxidation, superoxide dismutase, glutathione peroxidase and serum and leukocyte vitamin C levels of patients with type II diabetes mellitus. Clin. Chim. Acta 1996; 244: 221
   Google Scholar
• Albrecht J. H., Hansen L. K. Cyclin D1 promotes mitogen-independent cell cycle progression in hepatocytes. Cell Growth Differ. 1999; 10: 397
   PubMedGoogle Scholar
• Alexander D. P., Britton H. G., Cohen N. M., Mashiter K., Nixon D. A., Smith F. G., Jr. Streptozotocin induced diabetes in the newborn lamb. Biol. Neonate 1971; 17: 381
   Google Scholar
• Al-Salman J., Arjomand H., Kemp D. G., Mittal M. Hepatocellular injury in a patient receiving rosiglitazone. A case report. Ann. Intern. Med. 2000; 132: 121
   PubMed Web of Science ®Google Scholar
• Altomare E., Grattagliano I., Vendemaile G., Micelli-Ferrari T., Signorile A., Cardia L. Oxidative protein damage in human diabetic eye: Evidence of a retinal participation. Eur. J. Clin. Invest. 1997; 27: 141
   PubMed Web of Science ®Google Scholar
• Al-Turk W. A., Stohs S. J., Roche E. B. Altered activities of hepatic and extrahepatic microsomal mixed function oxidase enzymes in diabetic and adrenalectomized diabetic rats. Pharmacology 1981; 23: 337
   Google Scholar
• Am Esch J. S., 2nd, Knoefel W. T., Klein M., Ghodsizad A., Fuerst G., Poll L. W., Piechaczek C., Burchardt E. R., Feifel N., Stoldt V., Stockschlader M., Stoecklein N., Tustas R. Y., Eisenberger C. F., Peiper M., Haussinger D., Hosch S. B. Portal application of autologous CD133+ bone marrow cells to the liver: A novel concept to support hepatic regeneration. Stem Cells 2005; 23: 463
   PubMed Web of Science ®Google Scholar
• Anai M., Funaki M., Ogihara T., Terasaki J., Inukai K., Katagiri H., Fukushima Y., Yazaki Y., Kikuchi M., Oka Y., Asano T. Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats. Diabetes 1998; 47: 13
   PubMed Web of Science ®Google Scholar
• Anderson H. R., Stitt A. W., Gardiner T. A., Lloyd S. J., Archer D. B. Induction of alloxan/streptozotocin diabetes in dogs: A revised experimental technique. Lab. Anim. 1993; 27: 281
   PubMed Web of Science ®Google Scholar
• Anderson S. P., Yoon L., Richard E. B., Dunn C. S., Cattley R. C., Corton J. C. Delayed liver regeneration in peroxisome proliferator-activated receptor-alpha-null mice. Hepatology 2002; 36: 544
   PubMed Web of Science ®Google Scholar
• Andrade R. J., Lucena M. I., Rodriguez-Mendizabal M. Hepatic injury caused by acarbose. Ann. Intern. Med. 1996; 124: 931
   Google Scholar
• Andrade R. J., Lucena M., Vega J. L., Torres M., Salmeron F. J., Bellot V., Garcia-Escano M. D., Moreno P. Acarbose-associated hepatotoxicity. Diabetes Care 1998; 21: 2029
   Google Scholar
• Aniya Y., Ojiri Y., Sunagawa R., Murakami K., Zhenzhong G., Mimura G., Sakanashi M. Glutathione S-transferases and chloroform toxicity in streptozotocin-induced diabetic rats. Jpn. J. Pharmacol. 1989; 50: 263
   PubMedGoogle Scholar
• Annapurna V., Senciall I., Davis A. J., Kutty K. M. Relationship between serum pseudocholinesterase and triglycerides in experimentally induced diabetes mellitus in rats. Diabetologia 1991; 34: 320
   PubMed Web of Science ®Google Scholar
• Apte U. M., Limaye P. B., Ramaiah S. K., Desaiah D., Bucci T. J., Warbritton A., Mehendale H. M. Mechanisms of higher liver tissue repair and survival in diet restricted rats treated with thioacetamide. Toxicol. Sci. 2003; 72: 272
   PubMed Web of Science ®Google Scholar
• Aragno M., Tamagno E., Gatto V., Brignardello E., Parola S., Danni O., Boccuzzi G. Dehydroepiandrosterone protects tissues of streptozotocin-treated rats against oxidative stress. Free Radical Biol. Med. 1999; 26: 1467
   PubMed Web of Science ®Google Scholar
• Argiles J. M. The obese Zucker rat: a choice for fat metabolism 1968–1988: Twenty years of research on the insights of the Zucker mutation. Prog. Lipid Res. 1989; 28: 53
   Google Scholar
• Asayama K., Sandhir R., Sheikh F. G., Hayashibe H., Nakane T., Singh I. Increased peroxisomal fatty acid beta-oxidation and enhanced expression of peroxisome proliferator-activated receptor-alpha in diabetic rat liver. Mol. Cell Biochem. 1999; 194: 227
   Google Scholar
• Atalay M., Laaksonen D. E., Niskanen L., Uusitupa M., Hanninen O., Sen C. K. Altered antioxidant enzyme defences in insulin-dependent diabetic men with increased resting and exercise-induced oxidative stress. Acta Physiol. Scand. 1997; 161: 195
   PubMedGoogle Scholar
• Aughsteen A. A. An ultrastructural study on the effect of streptozotocin on the islets of Langerhans in mice. J. Electron Microsc. (Tokyo) 2000; 49: 681
   PubMedGoogle Scholar
• Awad M. M., Enslen H., Boylan J. M., Davis R. J., Gruppuso P. A. Growth regulation via p38 mitogen-activated protein kinase in developing liver. J. Biol. Chem. 2000; 275: 38716
   PubMed Web of Science ®Google Scholar
• Aznar Aznar A., Sanchez Canizares T., Bentura Remacha M. L., Lopez Alonso A., Diaz Pavon L. Effect of alloxan-induced diabetes on hepatic regeneration. Rev. Esp. Enferm. Dig. 1991; 79: 313, (abstract)
   Google Scholar
• Bae M. A., Song B. J. Critical role of c-Jun N-terminal protein kinase activation in troglitazone-induced apoptosis of human HepG2 hepatoma cells. Mol. Pharmacol. 2003; 63: 401
   PubMed Web of Science ®Google Scholar
• Bahjat F. R., Dharnidharka V. R., Fukuzuka K., Morel L., Crawford J. M., Clare-Salzler M. J., Moldawer L. L. Reduced susceptibility of nonobese diabetic mice to TNF-alpha and D-galactosamine-mediated hepatocellular apoptosis and lethality. J. Immunol. 2000; 165: 6559
   Google Scholar
• Bandyopadhyay A. M., Chaudhary I., Robertson L. W., Gemzik B., Parkinson A., Blouin R. A. Expression of a male-specific cytochrome P450 isozyme (CYP2C11) in fa/fa Zucker rats: Effect of phenobarbital treatment. Arch. Biochem. Biophys. 1993; 307: 386
   Google Scholar
• Barnett C. R., Abbott R. A., Bailey C. J., Flatt P. R., Ioannides C. Cytochrome P-450-dependent mixed-function oxidase and glutathione S-transferase activities in spontaneous obesity-diabetes. Biochem. Pharmacol. 1992; 43: 1868
   PubMed Web of Science ®Google Scholar
• Barnett C. R., Flatt P. R., Ioannides C. Modulation of the rat hepatic cytochrome P450 composition by long-term streptozotocin-induced insulin-dependent diabetes. J. Biochem. Toxicol. 1994; 9: 63
   PubMedGoogle Scholar
• Barnett C. R., Flatt P. R., Ioannides C. Induction of hepatic microsomal P450 I and IIB proteins by hyperketonaemia. Biochem. Pharmacol. 1990a; 40: 393
   PubMed Web of Science ®Google Scholar
• Barnett C. R., Gibson G. G., Wolf C. R., Flatt P. R., Ioannides C. Induction of cytochrome P450III and P450IV family proteins in streptozotocin-induced diabetes. Biochem. J. 1990b; 268: 765
   PubMed Web of Science ®Google Scholar
• Barnett C. R., Rudd S., Flatt P. R., Ioannides C. Sex differences in the diabetes-induced modulation of rat hepatic cytochrome P450 proteins. Biochem. Pharmacol. 1993; 45: 313
   PubMed Web of Science ®Google Scholar
• Barra R., Hall J. C. Liver regeneration in normal and alloxan-induced diabetic rats. J. Exp. Zool. 1977; 201: 93
   PubMedGoogle Scholar
• Bastar I., Seckin S., Uysal M., Aykac-Toker G. Effect of streptozotocin on glutathione and lipid peroxide levels in various tissues of rats. Res. Commun. Mol. Pathol. Pharmacol. 1998; 102: 265
   PubMedGoogle Scholar
• Baynes J. W. Role of oxidative stress in development of complications in diabetes. Diabetes. 1991; 40: 405
   PubMed Web of Science ®Google Scholar
• Baynes J. W., Thorpe S. R. Role of oxidative stress in diabetic complications: A new perspective on an old paradigm. Diabetes 1999; 48: 1
   PubMed Web of Science ®Google Scholar
• Bellward G. D., Chang T., Rodrigues B., McNeill J. H., Maines S., Ryan D. E., Levin W., Thomas P. E. Hepatic cytochrome P-450 induction in the spontaneously diabetic BB rat. Mol. Pharmacol. 1988; 33: 140
   PubMed Web of Science ®Google Scholar
• Blouin R. A., Bandyopadhyay A. M., Chaudhary I., Robertson L. W., Gemzik B., Parkinson A. Cytochrome P450 2B enzyme (CYP2B) induction defect following phenobarbital treatment in the fa/fa Zucker rat: Molecular characterization. Arch. Biochem. Biophys. 1993; 303: 313
   PubMed Web of Science ®Google Scholar
• Boelsterli U. A. Disease-related determinants of susceptibility to drug-induced idiosyncratic hepatotoxicity. Curr. Opin. Drug Discov. Devel. 2003; 6: 81
   PubMed Web of Science ®Google Scholar
• Bonkovsky H. L., Azar R., Bird S., Szabo G., Banner B. Severe cholestatic hepatitis caused by thiazolidinediones: Risks associated with substituting rosiglitazone for troglitazone. Dig. Dis. Sci. 2002; 47: 1632
   PubMed Web of Science ®Google Scholar
• Booth A. M., Caldwell S. H., Iezzoni J. C. Troglitazone-associated hepatic failure. Am. J. Gastroenterol. 2000; 95: 557
   PubMed Web of Science ®Google Scholar
• Borthwick E. B., Burchell A., Coughtrie M. W. Differential expression of hepatic oestrogen, phenol and dehydroepiandrosterone sulphotransferases in genetically obese diabetic (ob/ob) male and female mice. J. Endocrinol. 1995; 144: 31
   PubMed Web of Science ®Google Scholar
• Braun L., Coffey M. J., Puskas F., Kardon T., Nagy G., Conley A. A., Burchell B., Mandl J. Molecular basis of bilirubin UDP-glucuronosyltransferase induction in spontaneously diabetic rats, acetone-treated rats and starved rats. Biochem. J. 1998; 336: 587
   Google Scholar
• Brenner D. A. Signal transduction during liver regeneration. J. Gastroenterol. Hepatol. 1998; 13: S93
   Google Scholar
• Brownlee M. Lilly Lecture 1993. Glycation and diabetic complications. Diabetes 1993; 43: 836
   Google Scholar
• Brownlee M. Advanced protein glycosylation in diabetes and aging. Annu. Rev. Med. 1995; 46: 223
   PubMed Web of Science ®Google Scholar
• Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001; 414: 813
   PubMed Web of Science ®Google Scholar
• Bruccoleri A., Gallucci R., Germolec D. R., Blackshear P., Simeonova P., Thurman R. G., Luster M. I. Induction of early-immediate genes by tumor necrosis factor alpha contribute to liver repair following chemical-induced hepatotoxicity. Hepatology 1997; 25: 133
   PubMed Web of Science ®Google Scholar
• Carmiel-Haggai M., Cederbaum A. I., Nieto N. Binge ethanol exposure increases liver injury in obese rats. Gastroenterology 2003; 125: 1818
   PubMed Web of Science ®Google Scholar
• Carnovale C. E., Catania V. A., Monti J. A., Carrillo M. C. Differential effects of blood insulin levels on microsomal enzyme activities from hepatic and extrahepatic tissues of male rats. Can. J. Physiol. Pharmacol. 1992; 70: 727
   Google Scholar
• Carrascosa M., Pascual F., Aresti S. Acarbose-induced acute severe hepatotoxicity. Lancet 1997; 349: 698
   PubMed Web of Science ®Google Scholar
• Caruana J. A., Whalen D. A., Jr, Anthony W. P., Sunby C. R., Ciechoski M. P. Paradoxical effects of glucose feeding on liver regeneration and survival after partial hepatectomy. Endocr. Res. 1986; 12: 147
   Web of Science ®Google Scholar
• Catala J., Hadjiisky P., Bonnafous R., Fichaux F. Cell features in pancreas of prediabetic and diabetic rabbits after Wirsung duct ligation. Histochemical and histoenzymatic studies. Acta Diabetol. Lat. 1990; 27: 59
   Google Scholar
• Catala J., Daumas M., Chanh A. P., Lasserre B., Hollande E. Insulin and glucagon impairments in relation with islet cells morphological modifications following long term pancreatic duct ligation in the rabbit—A model of noninsulin-dependent diabetes. Int. J. Exp. Diabetes Res. 2001; 2: 101
   Google Scholar
• Cataldegirmen G., Zeng S., Feirt N., Ippagunta N., Dun H., Qu W., Lu Y., Rong L. L., Hofmann M. A., Kislinger T., Pachydaki S. I., Jenkins D. G., Weinberg A., Lefkowitch J., Rogiers X., Yan S. F., Schmidt A. M., Emond J. C. RAGE limits regeneration after massive liver injury by coordinated suppression of TNF-alpha and NF-kappaB. J. Exp. Med. 2005; 201: 473
   PubMed Web of Science ®Google Scholar
• Cerami A., Vlassara H., Brownlee M. Role of advanced glycosylation products in complications of diabetes. Diabetes Care 1988; 11: 73, (Suppl. 1)
   PubMed Web of Science ®Google Scholar
• Cervinkova Z., Kalinova M., Simek J. The effect of carnitine on the early phase of liver regeneration after partial hepatectomy in rats with experimental diabetes. Bratisl. Lek. Listy. 1992; 93: 359, (abstract)
   Google Scholar
• Chance B., Sies H., Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol. Rev. 1979; 59: 527
   PubMed Web of Science ®Google Scholar
• Chanda S., Mehendale H. M. Nutritional impact on the final outcome of liver injury inflicted by model hepatotoxins: effect of glucose loading. FASEB J. 1995; 9: 240
   PubMedGoogle Scholar
• Chen G. F., Ronis M. J., Ingelman-Sundberg M., Badger T. M. Hormonal regulation of microsomal cytochrome P4502E1 and P450 reductase in rat liver and kidney. Xenobiotica 1999; 29: 437–451
   PubMed Web of Science ®Google Scholar
• Chen X., Zheng Y., Shen Y. Voglibose (Basen, AO-128), one of the most important alpha-glucosidase inhibitors. Curr. Med. Chem. 2006; 13: 109
   PubMed Web of Science ®Google Scholar
• Chilakapati J., Korrapati M. C., Hill R. A., Warbritton A., Latendresse J. R., Mehendale H. M. Role of thioacetamide sfoxide in saturation of Toxicokinetics of thioacetamide. Toxicology 2007a, in press
   Google Scholar
• Chilakapati J., Korrapati M. C., Shankar K., Hill R. A., Warbritton A., Latendresse J. R., Mehendale H. M. Role of CYP2E1 and saturation kinetics in the bioactivation of thioacetamide: Effects of diet restriction and phenobarbital. Toxicol. Appl. Pharmacol. 2007b, in press
   Google Scholar
• Chin S., Ramirez S., Greenbaum L. E., Naji A., Taub R. Blunting of the immediate-early gene and mitogenic response in hepatectomized type 1 diabetic animals. Am. J. Physiol. 1995; 269: E691
   Web of Science ®Google Scholar
• Cillo U., Vitale A., Brolese A., Zanus G., Bassanello M., Montin U., D'Amico F., Ciarleglio F. A., Iurilli V., Carraro P., Grigoletto F., Plebani M., D'Amico D. F. Syngeneic living-donor liver transplantation for hemangioendothelioma: A clinical model for studying liver regeneration. Am. J. Transplant 2005; 5: 2309
   Google Scholar
• Clarke J., Snelling J., Ioannides C., Flatt P. R., Barnett C. R. Effect of vitamin C supplementation on hepatic cytochrome P450 mixed-function oxidase activity in streptozotocin-diabetic rats. Toxicol. Lett. 1996; 89: 249
   Google Scholar
• Conaway H. H., Brown C. J., Sanders L. L., Cernosek S. F., Farris H. E., Roth S. I. Spontaneous diabetes mellitus in the New Zealand white rabbit: History, classification, and genetic analysis. J. Hered. 1980; 71: 179–186
   Google Scholar
• Cornwell P. D., Watkins J. B. Changes in the kinetic parameters of hepatic gamma-glutamyltransferase from streptozotocin-induced diabetic rats. Biochem. Biophys. Acta 2001; 1545: 184
   Google Scholar
• Coughtrie M. W., Pears J., Jones A. L., Burchell A. Cytosolic phenol and steroid sulphotransferase activities are decreased in a sex-dependent manner in streptozotocin-induced diabetic rats. Biochem. Pharmacol. 1990; 40: 2180
   PubMed Web of Science ®Google Scholar
• Crabb D. W. The effect of experimental diabetes on liver alcohol dehydrogenase activity in rats. Alcohol Clin. Exp. Res. 1986; 10: 77
   PubMed Web of Science ®Google Scholar
• Dahlke M. H., Popp F. C., Bahlmann F. H., Aselmann H., Jager M. D., Neipp M., Piso P., Klempnauer J., Schlitt H. J. Liver regeneration in a retrorsine/CCl4-induced acute liver failure model: Do bone marrow-derived cells contribute?. J. Hepatol. 2003; 39: 365
   Google Scholar
• Dajani O. F., Refsnes M., Guren T. K., Horn R. S., Thoresen G. H., Christoffersen T. Elevated glucose concentrations inhibit DNA synthesis and expression of c-myc in cultured hepatocytes. Biochem. Biophys. Res. Commun. 1994; 202: 1476
   PubMed Web of Science ®Google Scholar
• Davis R. MAPKs: new JNK expands the group. Trends in Biochem. Sci. 1994; 19: 470
   PubMed Web of Science ®Google Scholar
• De Diego J. A., Molina L. M., Bujan J., Simon P., Gea M., Menchero A., Balibrea J. L. Influence of the conjoint administration of insulin and glucagon upon hepatic regeneration. Surg. Gynecol. Obstet. 1986; 163: 443
   PubMedGoogle Scholar
• De Vos A., Heimberg H., Quartier E., Huypens P., Bouwens L., Pipeleers D., Schuit F. Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression. J. Clin. Invest. 1995; 96: 2489
   PubMed Web of Science ®Google Scholar
• Del Villar E., Vega P., Gaule C., Sanchez E. Diabetes in female rats; changes in liver microsomal aminopyrine N-demethylase and UDP-glucuronyl transferase activities. Eur. J. Drug Metab. Pharmacokinet. 1990; 15: 279
   Google Scholar
• Devi S. S., Mehendale H. M. Disrupted G1 to S phase clearance via cyclin signaling impairs liver tissue repair in thioacetamide-treated type 1 diabetic rats. Toxicol. Appl. Pharmacol. 2005a; 207: 89
   Google Scholar
• Devi S. S., Mehendale H. M. The role of NF-kappaB signaling in impaired liver tissue repair in thioacetamide-treated type 1 diabetic rats. Eur. J. Pharmacol. 2005b; 523: 127
   Google Scholar
• Devi S. S., Mehendale H. M. Microarray analysis of thioacetamide-treated type 1 diabetic rats. Toxicol. Appl. Pharmacol. 2006; 212: 69
   Google Scholar
• Devi S. S., Philip B. K., Warbritton A., Latendresse J. R., Mehendale H. M. Prior administration of thioacetamide protects type 1 diabetic rats from subsequent administration of lethal dose of thioacetamide. Toxicology 2006; 226: 107
   Google Scholar
• Dharancy S., Malapel M., Perlemuter G., Roskams T., Podevin P., Conti F., Canva V., Gambiez L., Calmus Y., Mathurin P., Pol S., Brechot C., Auwerx J., Desreumaux P. Impaired liver expression of the PPAR-α modulates liver steatosis and inflammation during hepatitis C virus infection. Hepatology 2002; 36: 264A
   Google Scholar
• Di Campli C., Piscaglia A. C., Rutella S., Bonanno G., Vecchio F. M., Zocco M. A., Monego G., Michetti F., Mancuso S., Pola P., Leone G., Gasbarrini G., Gasbarrini A. Improvement of mortality rate and decrease in histologic hepatic injury after human cord blood stem cell infusion in a murine model of hepatotoxicity. Transplant Proc. 2005; 37: 2707
   Google Scholar
• Diehl A. M., Rai R. M. Liver regeneration 3: Regulation of signal transduction during liver regeneration. FASEB J. 1996; 10: 215
   PubMedGoogle Scholar
• Diehl A. M., Yin M., Fleckenstein J., Yang S. Q., Lin H. Z., Brenner D. A., Westwick J., Bagby G., Nelson S. Tumor necrosis factor-alpha induces c-jun expression during the regenerative responses to liver injury. Am. J. Physiol. 1994; 30: G552
   Google Scholar
• Diehl A. M., Yang S. Q., Yin M., Lin H. Z., Nelson S., Bagby G. Tumor necrosis factor-alpha modulates CCAAT/enhancer binding proteins-DNA binding activities and promotes hepatocyte-specific gene expression during liver regeneration. Hepatology 1995; 22: 252
   PubMedGoogle Scholar
• Dincer Y., Alademir Z., Ilkova H., Akcay T. Susceptibility of glutatione and glutathione-related antioxidant activity to hydrogen peroxide in patients with type 2 diabetes: effect of glycemic control. Clin. Biochem. 2002; 35: 297
   Google Scholar
• Donahower B., McCullough S. S., Kurten R., Lamps L. W., Simpson P., Hinson J. A., James L. P. Vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity. Am. J. Physiol. Gastrointest. Liver Physiol. 2006; 291: G102
   Google Scholar
• Donahue B. S., Morgan E. T. Effects of vanadate on hepatic cytochrome P-450 expression in streptozotocin-diabetic rats. Drug Metab. Dispos. 1990; 18: 519
   Google Scholar
• Donahue B. S., Skottner-Lundin A., Morgan E. T. Growth hormone-dependent and-independent regulation of cytochrome P-450 isozyme expression in streptozotocin-diabetic rats. Endocrinology 1991; 128: 2065
   Google Scholar
• Dong Z. G., Hong J. Y., Ma Q. A., Li D. C., Bullock J., Gonzalez F. J., Park S. S., Gelboin H. V., Yang C. S. Mechanism of induction of cytochrome P-450ac (P-450j) in chemically induced and spontaneously diabetic rats. Arch. Biochem. Biophys. 1988; 263: 29
   PubMed Web of Science ®Google Scholar
• Donthamsetty S., Bhave V. S., Mitra S. M., Latendresse J. R., Mehendale H. M. Nonalcoholic fatty liver sensitizes rats to carbon tetrachloride hepatotoxicity. Hepatology 2007; 45: 391
   PubMed Web of Science ®Google Scholar
• Dranoff J. A., Masyuk A. I., Kruglov E. A., LaRusso N. F., Nathanson M. H. Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia. Am. J. Physiol. Gastrointest. Liver Physiol. 2001; 281: G1059
   Google Scholar
• Driggers W. J., LeDoux S. P., Wilson G. L. Repair of oxidative damage within the mitochondrial DNA of RINr 38 cells. J Biol Chem. 1993; 268: 22042
   PubMed Web of Science ®Google Scholar
• Du X. L., Edelstein D., Dimmeler S., Ju Q., Sui C., Brownlee M. Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site. J. Clin. Invest. 2001; 108: 1341
   PubMed Web of Science ®Google Scholar
• Dulin W. E., Wyse B. M. Reversal of streptozotocin diabetes with nicotinamide. Proc. Soc. Exp. Biol. Med. 1969; 130: 992
   Google Scholar
• Duzgun S. A., Rasque H., Kito H., Azuma N., Li W., Basson M. D., Gahtan V., Dudrick S. J., Sumpio B. E. Mitogen-activated protein phosphorylation in endothelial cells exposed to hyperosmolar conditions. J. Cell Biochem. 2000; 76: 567
   Google Scholar
• Eacho P. I., Sweeny D., Weiner M. Conjugation of p-nitroanisole and p-nitrophenol in hepatocytes isolated from streptozotocin diabetic rats. J. Pharmacol. Exp. Ther. 1981; 218: 34
   PubMed Web of Science ®Google Scholar
• El-Hawari A. M., Plaa G. L. Potentiation of thioacetamide-induced hepatotoxicity in alloxan-and streptozotocin-diabetic rats. Toxicol. Lett. 1983; 17: 293
   Google Scholar
• El-Serag H. B., Everhart J. E. Diabetes increases the risk of acute hepatic failure. Gastroenterology 2002; 122: 1822
   PubMed Web of Science ®Google Scholar
• El-Serag H. B., Tran T., Everhart J. E. Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma. Gastroenterology 2004; 126: 460
   PubMed Web of Science ®Google Scholar
• Engels W., van Bilsen M., Wolffenbuttel B. H., van der Vusse G. J., Glatz J. F. Cytochrome P450, peroxisome proliferation, and cytoplasmic fatty acid-binding protein content in liver, heart and kidney of the diabetic rat. Mol. Cell Biochem. 1999; 192: 53
   PubMed Web of Science ®Google Scholar
• English J. C., Anders M. W. Evidence for the metabolism of N-nitrosodimethylamine and carbon tetrachloride by a common isozyme of cytochrome P-450. Drug Metab. Dispos. 1985; 13: 449
   PubMedGoogle Scholar
• Enriquez A., Leclercq I., Farrell G. C., Robertson G. Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats. Biochem. Biophys. Res. Commun. 1999; 255: 300
   PubMed Web of Science ®Google Scholar
• Evans J. L., Goldfine I. D., Maddux B. A., Grodsky G. M. Oxidative stress and stress-activated signaling pathways: A unifying hypothesis of type 2 diabetes. Endocr. Rev. 2002; 23: 599
   PubMed Web of Science ®Google Scholar
• Faggioni R., Jones-Carson J., Reed D. A., Dinarello C. A., Feingold K. R., Grunfeld C., Fantuzzi G. Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: Role of tumor necrosis factor alpha and IL-18. Proc. Natl. Acad. Sci. USA 2000; 97: 2367
   PubMed Web of Science ®Google Scholar
• Fausto N. Liver regeneration. J. Hepatol. 2000; 32: 19
   PubMed Web of Science ®Google Scholar
• Fausto N., Laird A. D., Webber E. M. Liver regeneration 2: Role of growth factors and cytokines in hepatic regeneration. FASEB J. 1995; 9: 1527
   PubMed Web of Science ®Google Scholar
• Fausto N., Mead J. E., Braun L., Thompson N. L., Panzica M., Goyette M., Bell G. I., Shank P. R. Proto-oncogene expression and growth factors during liver regeneration. Symp. Fundam. Cancer Res. 1986; 39: 69
   Google Scholar
• Fausto N., Riehle K. J. Mechanisms of liver regeneration and their clinical implications. J. Hepatobiliary Pancreat. Surg. 2005; 12: 181
   PubMedGoogle Scholar
• Fausto N., Webber E. M. Control of liver growth. Crit. Rev. Eukaryot. Gene Expr. 1993; 3: 117
   PubMedGoogle Scholar
• Favreau L. V., Schenkman J. B. Composition changes in hepatic microsomal cytochrome P-450 during onset of streptozotocin-induced diabetes and during insulin treatment. Diabetes 1988a; 37: 577
   PubMed Web of Science ®Google Scholar
• Favreau L. V., Schenkman J. B. Cytochrome P-450 alterations in the BB/Wor spontaneously diabetic rat. Biochem. Pharmacol. 1988b; 37: 3505
   PubMed Web of Science ®Google Scholar
• Feranchak A. P., Fitz J. G., Roman R. M. Volume-sensitive purinergic signaling in human hepatocytes. J. Hepatol. 2000; 33: 174
   Google Scholar
• Fernandez-Martinez A., Callejas N. A., Casado M., Bosca L., Martin-Sanz P. Thioacetamide-induced liver regeneration involves the expression of cyclooxygenase 2 and nitric oxide synthase 2 in hepatocytes. J. Hepatol. 2004; 40: 963
   PubMed Web of Science ®Google Scholar
• Ferguson N. L., Donahue B. S., Tenney K. A., Morgan E. T. Pretranslational induction of CYP4A subfamily gene products in diabetic rats and reversal by oral vanadate treatment. Drug Metab. Dispos. 1993; 21: 745
   Google Scholar
• Field C. J., Butler S. C. The BB rats: A unique model of human type I diabetes. Experimental models of diabetes, J. H. McNeill. CRC Press, Boca Raton, FL 1999; 296
   Google Scholar
• Fischer L. J., Rickert D. E. Pancreatic islet-cell toxicity. Crit. Rev. Toxicol. 1975; 3: 231
   Google Scholar
• Forman L. M., Simmons D. A., Diamond R. H. Hepatic failure in a patient taking rosiglitazone. Ann. Intern. Med. 2000; 132: 118
   PubMed Web of Science ®Google Scholar
• Fontana R. J., Quallich L. G. Acute liver failure. Curr. Opin. Gastroenterol. 2001; 17: 291
   Google Scholar
• Fredenrich A., Grimaldi P. A. PPAR delta: an uncompletely known nuclear receptor. Diabetes Metab. 2005; 31: 23
   PubMed Web of Science ®Google Scholar
• Frigeri L. G., Wolff G. L., Robel G. Impairment of glucose tolerance in yellow (Avy/A) (BALB/c × VY) F-1 hybrid mice by hyperglycemic peptide(s) from human pituitary glands. Endocrinology 1983; 113: 2097
   Google Scholar
• Fukano M., Amano S., Sato J., Yamamoto K., Adachi H., Okabe H., Fujiyama Y., Bamba T. Subacute hepatic failure associated with a new antidiabetic agent, troglitazone: A case report with autopsy examination. Hum. Pathol. 2000; 31: 250
   PubMed Web of Science ®Google Scholar
• Fukuhara K., Suzuki M., Unno M., Rahman M. M., Endo K., Matsuno S. The degree of hepatic regeneration after partial hepatectomy in rats with peritonitis and the role of lipid peroxidation. Free Radic. Biol. Med. 1999; 26: 881
   Google Scholar
• Funae Y., Imaoka S., Shimojo N. Purification and characterization of diabetes-inducible cytochrome P-450. Biochem. Int. 1988; 16: 503
   PubMedGoogle Scholar
• Funk C., Ponelle C., Scheuermann G., Pantze M. Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: In vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat. Mol. Pharmacol. 2001; 59: 627
   PubMed Web of Science ®Google Scholar
• Gabel H., Bitter-Suermann H., Henriksson C., Save-Soderbergh J., Lundholm K., Brynger H. Streptozotocin diabetes in juvenile pigs. Evaluation of an experimental model. Horm. Metab. Res. 1985; 17: 275
   PubMedGoogle Scholar
• Galun E., Axelrod J. H. The role of cytokines in liver failure and regeneration: Potential new molecular therapies. Biochim. Biophys. Acta 2002; 1592: 345
   PubMed Web of Science ®Google Scholar
• Galun E., Zeira E., Pappo O., Peters M., Rose-John S. Liver regeneration induced by a designer human IL-6/sIL-6R fusion protein reverses severe hepatocellular injury. FASEB J. 2000; 14: 1979
   Google Scholar
• Gawronska-Szklarz B., Musial D., Drozdzik M., Paprota B. Metabolism of lidocaine by liver microsomes from streptozotocin-diabetic rats. Pol. J. Pharmacol. 2003; 55: 251
   Google Scholar
• Gaynes B. I., Watkins J. B., 3rd. Carbon tetrachloride and the sorbitol pathway in the diabetic mouse. Comp. Biochem. Physiol. B. 1989; 94: 213
   Google Scholar
• Gentile S., Turco S., Guarino G., Sasso F. C., Torella R. Aminotransferase activity and acarbose treatment in patients with type 2 diabetes. Diabetes Care 1999; 22: 1217
   Google Scholar
• Gherzi R., Andraghetti G., Ferrannini E., Cordera R. Insulin receptor autophosphorylation and kinase activity in streptozotocin diabetic rats. Effect of a short fast. Biochem. Biophys. Res. Commun. 1986; 140: 850
   Google Scholar
• Gill A. M., Leiter E. H., Powell J. G., Chapman H. D., Yen T. T. Dexamethasone-induced hyperglycemia in obese Avy/a (viable yellow) female mice entails preferential induction of a hepatic estrogen sulfotransferase. Diabetes 1994; 43: 999
   PubMed Web of Science ®Google Scholar
• Gitlin N., Julie N. L., Spurr C. L., Lim K. N., Juarbe H. M. Two cases of severe clinical and histologic hepatotoxicity associated with troglitazone. Ann. Intern. Med. 1998; 129: 36
   PubMed Web of Science ®Google Scholar
• Giugliano D., Ceriello A., Paolisso G. Oxidative stress and diabetic vascular complications. Diabetes Care 1996; 19: 257
   PubMed Web of Science ®Google Scholar
• Goel K. A. Submassive necrosis of liver of Channa gachua, a fresh water fish during experimental alloxan diabetes. Anat. Anz. 1977; 141: 130
   Google Scholar
• Gokcora N., Gundogdu S., Aricioglu A., Erbas D., Durmus O., Turkozkan N. The effect of epidermal growth factor on liver lipid peroxidation and glutathione levels in lobectomized rats. Biochem. Cell Biol. 1992; 70: 259
   Google Scholar
• Gonzalez J., Fevery J. Spontaneously diabetic biobreeding rats and impairment of bile acid-independent bile flow and increased biliary bilirubin, calcium and lipid secretion. Hepatology 1992; 16: 426
   Google Scholar
• Gopaul N. K., Anggard E. E., Mallet A. I., Betteridge D. J., Wolff S. P., Nourooz-Zadeh J. Plasma 8-epi-PGF2 alpha levels are elevated in individuals with noninsulin dependent diabetes mellitus. FEBS Lett. 1995; 368: 225
   PubMed Web of Science ®Google Scholar
• Graber R., Farine J. C., Fumagalli I., Tatti V., Losa G. A. Apoptosis and oxidative status in peripheral blood mononuclear cells of diabetic patients. Apoptosis 1999; 4: 263
   Google Scholar
• Grant M. H., Duthie S. J. Conjugation reactions in hepatocytes isolated from streptozotocin-induced diabetic rats. Biochem. Pharmacol. 1987; 36: 3647
   Google Scholar
• Grant M. H., Duthie S. J. The cytotoxicity of menadione in hepatocytes isolated from streptozotocin-induced diabetic rats. Biochem. Pharmacol. 1988; 37: 3793–3796
   Google Scholar
• Greco D. S. Diagnosis of diabetes mellitus in cats and dogs. Vet. Clin. North Am. Small Anim. Pract. 2001; 31: 845
   PubMed Web of Science ®Google Scholar
• Grussner R., Nakhleh R., Grussner A., Tomadze G., Diem P., Sutherland D. Streptozotocin-induced diabetes mellitus in pigs. Horm. Metab. Res. 1993; 25: 199
   PubMed Web of Science ®Google Scholar
• Guebre-Xabier M., Yang S., Lin H. Z., Schwenk R., Krzych U., Diehl A. M. Altered hepatic lymphocyte subpopulations in obesity-related murine fatty livers: Potential mechanism for sensitization to liver damage. Hepatology 2000; 31: 633
   PubMed Web of Science ®Google Scholar
• Guengerich F. P., Kim D. H., Iwasaki M. Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem. Res. Toxicol. 1991; 4: 168
   PubMed Web of Science ®Google Scholar
• Guerrieri F., Muolo L., Cocco T., Capozza G., Turturro N., Cantatore P., Papa S. Correlation between rat liver regeneration and mitochondrial energy metabolism. Biochim. Biophys. Acta 1995; 1272: 95
   Google Scholar
• Gupta R. R., Agrawal C. G., Shukla G. S., Ali B. Cytochrome P450-dependent oxidation and glutathione conjugation of xenobiotics in alloxan-induced diabetic rat. Res. Commun. Mol. Pathol. Pharmacol. 1997; 98: 231
   PubMedGoogle Scholar
• Haber B. A., Chin S., Chuang E., Buikhuisen W., Naji A., Taub R. High levels of glucose-6-phosphatase gene and protein expression reflect an adaptive response in proliferating liver and diabetes. J. Clin. Invest. 1995; 95: 832
   PubMed Web of Science ®Google Scholar
• Halliwell B. Antioxidant characterization. Methodology and mechanism. Biochem. Pharmacol. 1995; 49: 1341
   PubMed Web of Science ®Google Scholar
• Hanafusa T., Miyagawa J., Nakajima H., Tomita K., Kuwajima M., Matsuzawa Y., Tarui S. The NOD mouse. Diabetes Res. Clin. Pract. Suppl. 1994; S307
   Google Scholar
• Hanasono G. K., Cote M. G., Plaa G. L. Potentiation of carbon tetrachloride-induced hepatotoxicity in alloxan-or streptozotocin-diabetic rats. J. Pharmacol. Exp. Ther. 1975a; 192: 592
   PubMed Web of Science ®Google Scholar
• Hanasono G. K., Witschi H., Plaa G. L. Potentiation of the hepatotoxic responses to chemicals in alloxan-diabetic rats. Proc. Soc. Exp. Biol. Med. 1975b; 149: 903
   PubMed Web of Science ®Google Scholar
• Hannon-Fletcher M. P., O'Kane M. J., Moles K. W., Barnett Y. A., Barnett C. R. Lymphocyte cytochrome P450-CYP2E1 expression in human IDDM subjects. Food Chem. Toxicol. 2001; 39: 125
   PubMed Web of Science ®Google Scholar
• Hans C. P., Chaudhary D. P., Bansal D. D. Effect of magnesium supplementation on oxidative stress in alloxanic diabetic rats. Magnes. Res. 2003; 16: 13
   PubMed Web of Science ®Google Scholar
• Hansen B. C., Bodkin N. L. Primary prevention of diabetes mellitus by prevention of obesity in monkeys. Diabetes 1993; 42: 1809
   PubMedGoogle Scholar
• Harrison P. M., Hughes R. D., Forbes A., Portmann B., Alexander G. J., Williams R. Failure of insulin and glucagon infusion to stimulate liver regeneration in fulminant hepatic failure. J. Hepatol. 1990; 10: 332
   Google Scholar
• Hartnett M. E., Stratton R. D., Browne R. W., Rosner B. A., Lanham R. J., Armstrong D. Serum markers of oxidative stress and severity of diabetic retinopathy. Diabetes Care 2000; 23: 234
   PubMed Web of Science ®Google Scholar
• Haufroid V., Ligocka D., Buysschaert M., Horsmans Y., Lison D. Cytochrome P4502E1 (CYP2E1) expression in peripheral blood lymphocytes: Evaluation in hepatitis C and diabetes. Eur. J. Clin. Pharmacol. 2003; 59: 29
   PubMed Web of Science ®Google Scholar
• He K., Woolf T. F., Kindt E. K., Fielder A. E., Talaat R. E. Troglitazone quinone formation catalyzed by human and rat CYP3A: An atypical CYP oxidation reaction. Biochem. Pharmacol. 2001; 62: 191
   PubMed Web of Science ®Google Scholar
• Held W., MacDonald H. R., Weissman I. L., Hess M. W., Mueller C. Genes encoding tumor necrosis factor α and granzyme A are expressed during development of autoimmune diabetes. Proc. Natl. Acad. Sci. USA 1990; 87: 2239
   PubMed Web of Science ®Google Scholar
• Henderson C. J., Bammler T., Wolf C. R. Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a protein: Developmental and hormonal regulation in liver and kidney. Biochim. Biophys. Acta 1994; 1200: 182
   PubMedGoogle Scholar
• Heng Y. M., Kuo C. S., Jones P. S., Savory R., Schulz R. M., Tomlinson S. R., Gray T. J., Bell D. R. A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans. Biochem. J. 1997; 325: 741
   Google Scholar
• Herrman C. E., Sanders R. A., Klaunig J. E., Schwarz L. R., Watkins J. B., 3rd. Decreased apoptosis as a mechanism for hepatomegaly in streptozotocin-induced diabetic rats. Toxicol. Sci. 1999; 50: 146
   PubMed Web of Science ®Google Scholar
• Higdon H. L., 3rd, Parnell P. G., Hill J. E., Spitzer J. C. Streptozotocin-induced pancreatic islet destruction in beef cows. Vet. Pathol. 2001; 38: 715
   Google Scholar
• Higgins C. M., Anderson R. E. Experimental pathology of the liver. Arch. Pathol. 1931; 12: 186
   Google Scholar
• Hoenig M. Pathophysiology of canine diabetes. Vet. Clin. North Am. Small Anim. Pract. 1995; 25: 553
   Google Scholar
• Horn K. D., Wax P., Schneider S. M., Martin T. G., Nine J. S., Moraca M. A., Virji M. A., Aronica P. A., Rao K. N. Biomarkers of liver regeneration allow early prediction of hepatic recovery after acute necrosis. Am. J. Clin. Pathol. 1999; 112: 351
   PubMed Web of Science ®Google Scholar
• Howard C. F., Jr. Nonhuman primates as models for the study of human diabetes mellitus. Diabetes 1982; 31: 37
   Google Scholar
• Hsiao S. H., Liao L. H., Cheng P. N., Wu T. J. Hepatotoxicity associated with acarbose therapy. Ann. Pharmacother. 2006; 40: 151
   PubMed Web of Science ®Google Scholar
• Huo T. I., Lui W. Y., Huand Y. H., Chau G. Y., Wu J. C., Lee P. C., Chang F. Y., Lee S. D. Diabetes mellitus is a risk factor for hepatic decompensation in patients with hepatocellular carcinoma undergoing resection: A longitudinal study. Am. J. Gastroenterol. 2003; 98: 2293
   Google Scholar
• International Diabetes Federation, Facts & Figures. 2005, http://www.idf.org/home
   Google Scholar
• James L. P., Lamps L. W., McCullough S., Hinson J. A. Interleukin 6 and hepatocyte regeneration in acetaminophen toxicity in the mouse. Biochem. Biophys. Res. Commun. 2003; 309: 857
   PubMed Web of Science ®Google Scholar
• Jang Y. Y., Song J. H., Shin Y. K., Han E. S., Lee C. S. Protective effect of boldine on oxidative mitochondrial damage in streptozotocin-induced diabetic rats. Pharmacol. Res. 2000; 42: 361
   PubMed Web of Science ®Google Scholar
• Jeffery E. H., Arndt K., Haschek W. M. The role of cytochrome P450IIE1 in bioactivation of acetaminophen in diabetic and acetone-treated mice. Adv. Exp. Med. Biol. 1991; 283: 249
   Google Scholar
• Jick S. S., Stender M., Myers M. W. Frequency of liver disease in type 2 diabetic patients treated with oral antidiabetic agents. Diabetes Care 1999; 22: 2067
   PubMed Web of Science ®Google Scholar
• Johnston D. G., Johnson G. A., Alberti K. G., Millward-Sadler G. H., Mitchell J., Wright R. Hepatic regeneration and metabolism after partial hepatectomy in diabetic rats: Effects of insulin therapy. Eur. J. Clin. Invest. 1986; 16: 384–390
   Google Scholar
• Juan D., Molitch M. E., Johnson M. K., Carlson R. F., Antal E. J. Unaltered drug metabolizing enzyme systems in type II diabetes mellitus before and during glyburide therapy. J. Clin. Pharmacol. 1990; 30: 943
   Google Scholar
• Kaibori M., Inoue T., Oda M., Naka D., Kawaguchi T., Kitamura N., Miyazawa K., Kwon A. H., Kamiyama Y., Okumura T. Exogenously administered HGF activator augments liver regeneration through the production of biologically active HGF. Biochem. Biophys. Res. Commun. 2002; 290: 475
   Google Scholar
• Kasiske B. L., O'Donnell M. P., Keane W. F. The Zucker rat model of obesity, insulin resistance, hyperlipidemia, and renal injury. Hypertension 1992; 19: I110
   PubMed Web of Science ®Google Scholar
• Kassahun K., Pearson P. G., Tang W., McIntosh I., Leung K., Elmore C., Dean D., Wang R., Doss G., Baillie T. A. Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission. Chem. Res. Toxicol. 2001; 14: 62
   PubMed Web of Science ®Google Scholar
• Kawai K., Kawasaki-Tokui Y., Odaka T., Tsuruta F., Kazui M., Iwabuchi H., Nakamura T., Kinoshita T., Ikeda T., Yoshioka T., Komai T., Nakamura K. Disposition and metabolism of the new oral antidiabetic drug troglitazone in rats, mice and dogs. Arzneimittelforschung 1997; 47: 356
   PubMed Web of Science ®Google Scholar
• Kawakami S., Arima T., Harada K., Miyazono H., Oketani M., Miyazaki H., Arima T. Hepatic necrosis with cholestasis induced by long-term voglibose administration. Intern. Med. 2001; 40: 484
   PubMed Web of Science ®Google Scholar
• Kay M. A., Fausto N. Liver regeneration: Prospects for therapy based on new technologies. Mol. Med. Today 1997; 3: 108
   PubMedGoogle Scholar
• Kelder B., Boyce K., Matheny G., Kriete A., Cruz S. D., Braughler M., Kopchick J. J. Rapid and dramatic inhibition of Cyp3a11 and Cyp26 gene expression in a mouse model of obesity-induced type 2 diabetes. Endocr. Society 2004; 169, (Abstr.)
   Google Scholar
• Kelley D. E., He J., Menshikova E. V., Ritov V. B. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 2002; 51: 2944
   PubMed Web of Science ®Google Scholar
• Kesavulu M. M., Giri R., Kameswara Rao B., Apparao C. Lipid peroxidation and antioxidant enzyme levels in type 2 diabetics with microvascular complications. Diabetes Metab. 2000; 26: 387
   PubMed Web of Science ®Google Scholar
• Kim S. K., Abdelmegeed M. A., Novak R. F. Identification of the insulin signaling cascade in the regulation of alpha-class glutathione S-transferase expression in primary cultured rat hepatocytes. J. Pharmacol. Exp. Ther. 2006; 316: 1255
   PubMed Web of Science ®Google Scholar
• Kim S. K., Woodcroft K. J., Novak R. F. Insulin and glucagon regulation of glutathione S-transferase expression in primary cultured rat hepatocytes. J. Pharmacol. Exp. Ther. 2003; 305: 353
   PubMed Web of Science ®Google Scholar
• Kinalski M., Sledziewski A., Telejko B., Zarzycki W., Kinalska I. Lipid peroxidation and scavenging enzyme activity in streptozotocin-induced diabetes. Acta Diabetol. 2000; 37: 179
   PubMed Web of Science ®Google Scholar
• King P. A., Horton E. D., Hirshman M. F., Horton E. S. Insulin resistance in obese Zucker rat (fa/fa) skeletal muscle is associated with a failure of glucose transporter translocation. J. Clin. Invest. 1992; 90: 1568
   PubMed Web of Science ®Google Scholar
• Kirillova I., Chaisson M., Fausto N. Tumor necrosis factor induces DNA replication in hepatic cells through nuclear factor kappaB activation. Cell Growth Differ. 1999; 10: 819
   PubMedGoogle Scholar
• Kirkpatrick R. B., Kraft B. G. Effect of streptozotocin-induced diabetes on bile acid sulfation in male rat liver. Am. J. Physiol. 1984; 247: 226
   PubMedGoogle Scholar
• Klebig M. L., Wilkinson J. E., Geisler J. G., Woychik R. P. Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur. Proc. Natl. Acad. Sci. USA 1995; 23: 4728
   Google Scholar
• Kohlroser J., Mathai J., Reichheld J., Banner B. F., Bonkovsky H. L. Hepatotoxicity due to troglitazone: report of two cases and review of adverse events reported to the United States Food and Drug Administration. Am. J. Gastroenterol. 2000; 95: 272
   PubMed Web of Science ®Google Scholar
• Kolb H. Mouse models of insulin dependent diabetes: Low-dose streptozocin-induced diabetes and nonobese diabetic (NOD) mice. Diabetes Metab. Rev. 1987; 3: 751
   PubMed Web of Science ®Google Scholar
• Kostrubsky V. E., Sinclair J. F., Ramachandran V., Venkataramanan R., Wen Y. H., Kindt E., Galchev V., Rose K., Sinz M., Strom S. C. The role of conjugation in hepatotoxicity of troglitazone in human and porcine hepatocyte cultures. Drug Metab. Dispos. 2000; 28: 1192
   PubMed Web of Science ®Google Scholar
• Kraegen E. W., James D. E., Storlien L. H., Burleigh K. M., Chisholm D. J. In vivo insulin resistance in individual peripheral tissues of the high fat fed rat: Assessment by euglycaemic clamp plus deoxyglucose administration. Diabetologia 1986; 29: 192
   PubMed Web of Science ®Google Scholar
• Kroetz D. L., Yook P., Costet P., Bianchi P., Pineau T. Peroxisome proliferator-activated receptor alpha controls the hepatic CYP4A induction adaptive response to starvation and diabetes. J. Biol. Chem. 1998; 273: 31581
   PubMed Web of Science ®Google Scholar
• Kulkarni S. G., Warbeitton A., Bucci T. J., Mehendale H. M. Antimitotic intervention with colchicines alters the outcome of o-DCB-induced hepatotoxicity in Fischer 344 rats. Toxicology 1997; 120: 79
   Google Scholar
• Kumashiro R., Kubota T., Koga Y., Tanaka M., Inada C., Kusaba N., Yoshida H., Hisamochi A., Ide T., Tomita Y., Masumoto N., Tanikawa K., Iga T., Sata M. Association of troglitazone-induced liver injury with mutation of the cytochrome P450 2C19 gene. Hepatol. Res. 2003; 26: 337
   PubMed Web of Science ®Google Scholar
• Kushner B., Lazar M., Furman M., Lieberman T. W., Leopold I. H. Resistance of rabbits and guinea pigs to the diabetogenic effect of streptozotocin. Diabetes 1969; 18: 542
   Google Scholar
• Kutoh E. Possible metformin-induced hepatotoxicity. Am. J. Geriatr. Pharmacother. 2005; 3: 270
   Google Scholar
• Kutty K. M., Huang S. N., Kean K. T. Pseudocholinesterase in obesity: Hypercaloric diet induced changes in experimental obese mice. Experientia 1981; 37: 1141
   PubMedGoogle Scholar
• Kutty K. M., Payne R. H. Serum pseudocholinesterase and very-low-density lipoprotein metabolism. J. Clin. Lab. Anal. 1994; 8: 247
   PubMed Web of Science ®Google Scholar
• Laaksonen D. E., Atalay M., Niskanen L., Uusitupa M., Hanninen O., Sen C. K. Increased resting and exercise-induced oxidative stress in young IDDM men. Diabetes Care 1996; 19: 569
   PubMed Web of Science ®Google Scholar
• Ladosky E. M., Fonteles M. C. Presynaptic changes promoted by alloxan diabetes in the cat isolated heart. J. Pharm. Pharmacol. 1988; 40: 362
   Google Scholar
• Lakshman M. R., Chambers L. L., Chirtel S. J., Ekarohita N. Roles of hormonal and nutritional factors in the regulation of rat liver alcohol dehydrogenase activity and ethanol elimination rate in vivo. Alcohol Clin. Exp. Res. 1988; 12: 407
   PubMedGoogle Scholar
• Larsen M. O., Wilken M., Gotfredsen C. F., Carr R. D., Svendsen O., Rolin B. Mild streptozotocin diabetes in the Gottingen minipig. A novel model of moderate insulin deficiency and diabetes. Am. J. Physiol. Endocrinol. Metab. 2002; 282: E1342
   Google Scholar
• Latha M., Pari L. Effect of an aqueous extract of Scoparia dulcis on blood glucose, plasma insulin and some polyol pathway enzymes in experimental rat diabetes. Braz. J. Med. Biol. Res. 2004; 37: 577
   PubMed Web of Science ®Google Scholar
• Lavoie L. N., L'Allemain G., Brunet A., Muller R., Pouyssegur J. Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J. Biol. Chem. 1996; 271: 20608
   PubMed Web of Science ®Google Scholar
• Lazar M., Golden P., Furman M., Lieberman T. W. Resistance of the rabbit to streptozotocin. Lancet 1968; 2: 919
   Google Scholar
• Leclercq I. A., Field J., Enriquez A., Farrell G. C., Robertson G. R. Constitutive and inducible expression of hepatic CYP2E1 in leptin-deficient ob/ob mice. Biochem. Biophys. Res. Commun. 2000; 268: 337
   PubMed Web of Science ®Google Scholar
• Leclercq I. A., Field J., Farrell G. C. Leptin-specific mechanisms for impaired liver regeneration in ob/ob mice after toxic injury. Gastroenterology 2003; 124: 1451
   PubMed Web of Science ®Google Scholar
• LeDoux S. P., Hall C. R., Forbes P. M., Patton N. J., Wilson G. L. Mechanisms of nicotinamide and thymidine protection from alloxan and streptozocin toxicity. Diabetes 1988; 37: 1015
   Google Scholar
• Lee H. C., Curry D. L., Stern J. S. Direct effect of CNS on insulin hypersecretion in obese Zucker rats: Involvement of vagus nerve. Am. J. Physiol. 1989; 256: E439
   Google Scholar
• Leffert H. L., Koch K. S., Lad P. J., Shapiro I. P., Skelly H., de Hemptinnet B. Hepatocyte regeneration, replication, and differentiation. The Liver biology and pathbiology, I. M. Arias, W. B. Jackoby, H. Popper, D. Schachter, D. A. Shafritz. Raven Press, New York 1988; 883–850
   Google Scholar
• Leinonen J., Lehtimaki T., Toyokuni S., Okada K., Tanaka T., Hiai H., Ochi H., Laippala P., Rantalaiho V., Wirta O., Pasternack A., Alho H. New biomarker evidence of oxidative DNA damage in patients with non-insulin-dependent diabetes mellitus. FEBS Lett. 1997; 417: 150
   PubMed Web of Science ®Google Scholar
• Liatsos C., Hadjileontiadis L. J., Theocharis S., Petridou E., Margeli A., Skaltsas S., Mavrogiannis C., Mykoniatis M. Using higher-order crossings to distinguish liver regeneration indices in hepatectomized diabetic and non-diabetic rats. J. Gastroenterol. Hepatol. 2005; 20: 126
   Google Scholar
• Like A. A., Appel M. C., Williams R. M., Rossini A. A. Streptozotocin-induced pancreatic insulitis in mice. Morphologic and physiologic studies. Lab. Invest. 1978; 38: 470
   PubMedGoogle Scholar
• Like A. A., Rossini A. A. Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus. Science 1976; 193: 415
   PubMed Web of Science ®Google Scholar
• Like A. A., Rossini A. A., Guberski D. L., Appel M. C., Williams R. M. Spontaneous diabetes mellitus: reversal and prevention in the BB/W rat with antiserum to rat lymphocytes. Science 1979; 206: 1421
   PubMed Web of Science ®Google Scholar
• Lillioja S., Mott D. M., Spraul M., Ferraro R., Foley J. E., Ravussin E., Knowler W. C., Bennett P. H., Bogardus C. Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. N. Engl. J. Med. 1993; 329: 1988
   PubMed Web of Science ®Google Scholar
• Limaye P. B., Apte U. M., Shankar K., Bucci T. J., Warbritton A., Mehendale H. M. Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants. Toxicol. Appl. Pharmacol. 2003; 191: 211
   PubMed Web of Science ®Google Scholar
• Limaye P. B., Apte U. M., Yu S., Bhave V. S., Palkar P. S., Sawant S. P., Latendresse J. L., Reddy J. K., Mehendale H. M. Upregulation of calpastatin in regenerating and developing rat liver: role in resistance against hepatotoxicity. Hepatology 2006; 44: 379
   PubMed Web of Science ®Google Scholar
• Lips J. P., Jongsma H. W., Eskes T. K. Alloxan-induced diabetes mellitus in pregnant sheep and chronic fetal catheterization. Lab. Anim. 1988; 22: 16
   Google Scholar
• Liu S., Wang W., Luo X. M., Ye B. Chemically induced (streptozotocin-alloxan) diabetes mellitus in dogs. Hunan Yi Ke Da Xue Xue Bao 2000; 25: 125
   Google Scholar
• Litwak K. N., Cefalu W. T., Wagner J. D. Streptozotocin-induced diabetes mellitus in cynomolgus monkeys: changes in carbohydrate metabolism, skin glycation, and pancreatic islets. Lab. Anim. Sci. 1998; 48: 172
   Google Scholar
• Lorr N. A., Miller K. W., Chung H. R., Yang C. S. Potentiation of the hepatotoxicity of N-nitrosodimethylamine by fasting, diabetes, acetone, and isopropanol. Toxicol. Appl. Pharmacol. 1984; 73: 423
   PubMed Web of Science ®Google Scholar
• Lucas D., Farez C., Bardou L. G., Vaisse J., Attali J. R., Valensi P. Cytochrome P450 2E1 activity in diabetic and obese patients as assessed by chlorzoxazone hydroxylation. Fundam. Clin. Pharmacol. 1998; 12: 553
   PubMed Web of Science ®Google Scholar
• Lukic M. L., Stosic-Grujicic S., Shahin A. Effector mechanisms in low-dose streptozotocin-induced diabetes. Dev. Immunol. 1998; 6: 119
   PubMedGoogle Scholar
• Luo J., Quan J., Tsai J., Hobensack C. K., Sullivan C., Hector R., Reaven G. M. Nongenetic mouse models of non-insulin-dependent diabetes mellitus. Metabolism 1998; 47: 663
   PubMed Web of Science ®Google Scholar
• Ma Q., Dannan G. A., Guengerich F. P., Yang C. S. Similarities and differences in the regulation of hepatic cytochrome P-450 enzymes by diabetes and fasting in male rats. Biochem. Pharmacol. 1989; 38: 3179
   PubMed Web of Science ®Google Scholar
• Machowicz-Matejko E., Lancut M., Jedrych B., Zakrzewski P., Czerny K. Ultrastructural changes of ciliary epithelial nucleus in experimental diabetes—An animal model. Ann. Univ. Mariae. Curie. Sklodowska. 2002; 57: 61
   Google Scholar
• Madsen L., Petersen R. K., Kristiansen K. Regulation of adipocyte differentiation and function by polyunsaturated fatty acids. Biochim. Biophys. Acta 2005; 1740: 266
   PubMed Web of Science ®Google Scholar
• Mak D. H., Ko K. M. Alterations in susceptibility to carbon tetrachloride toxicity and hepatic antioxidant/detoxification system in streptozotocin-induced short-term diabetic rats: Effects of insulin and Schisandrin B treatment. Mol. Cell Biochem. 1997; 175: 225
   PubMedGoogle Scholar
• Malatjalian D. A., Ross J. B., Williams C. N., Colwell S. J., Eastwood B. J. Methotrexate hepatotoxicity in psoriatics: Report of 104 patients from Nova Scotia, with analysis of risks from obesity, diabetes and alcohol consumption during long term follow-up. Can. J. Gastroenterol. 1996; 10: 369
   PubMedGoogle Scholar
• Malik A. H., Prasad P., Saboorian M. H., Thiele D. L., Malet P. F. Hepatic injury due to troglitazone. Dig. Dis. Sci. 2000; 45: 210
   PubMed Web of Science ®Google Scholar
• Manautou J. E., Emeigh Hart S. G., Khairallah E. A., Cohen S. D. Protection against acetaminophen hepatotoxicity by a single dose of clofibrate: Effects on selective protein arylation and glutathione depletion. Fundam. Appl. Toxicol. 1996; 29: 229
   Google Scholar
• Manautou J. E., Hoivik D. J., Tveit A., Hart S. G., Khairallah E. A., Cohen S. D. Clofibrate pretreatment diminishes acetaminophen's selective covalent binding and hepatotoxicity. Toxicol. Appl. Pharmacol. 1994; 129: 252
   PubMed Web of Science ®Google Scholar
• Manautou J. E., Silva V. M., Hennig G. E., Whiteley H. E. Repeated dosing with the peroxisome proliferator clofibrate decreases the toxicity of model hepatotoxic agents in male mice. Toxicology 1998; 127: 1
   Google Scholar
• Mangipudy R. S., Rao P. S., Mehendale H. M. Effect of an antimitotic agent colchicine on thioacetamide hepatotoxicity. Environ. Health Perspect 1996; 104: 744
   Google Scholar
• Mansford K. R., Opie L. Comparison of metabolic abnormalities in diabetes mellitus induced by streptozotocin or by alloxan. Lancet 1968; 30: 670
   Google Scholar
• Marchesini G., Marzocchi R., Noia M., Bianchi G. Branched-chain amino acid supplementation in patients with liver diseases. J. Nutr. 2005; 135: 1596S
   Google Scholar
• Maritim A. C., Sanders R. A., Watkins J. B., 3rd. Diabetes, oxidative stress, and antioxidants: a review. J. Biochem. Mol. Toxicol. 2003; 17: 24
   PubMed Web of Science ®Google Scholar
• Maritim A. C., Moore B. H., Sanders R. A., Watkins J. B., 3rd. Effects of melatonin on oxidative stress in streptozotocin-induced diabetic rats. Intern. J. Toxicol. 1999; 18: 161
   Web of Science ®Google Scholar
• Martin G., Rand J. Current understanding of feline diabetes: Part 2, treatment. J. Feline Med. Surg. 2000; 2: 3
   PubMedGoogle Scholar
• Matsumoto T., Yamaguchi M., Kuzume M., Matsumiya A., Kumada K. Insulin gene transfer with adenovirus vector via the spleen safely and effectively improves posthepatectomized conditions in diabetic rats. J. Surg. Res. 2003; 110: 228
   Google Scholar
• Matzke G. R., Frye R. F., Early J. J., Straka R. J., Carson S. W. Evaluation of the influence of diabetes mellitus on antipyrine metabolism and CYP1A2 and CYP2D6 activity. Pharmacotherapy 2000; 20: 182
   PubMed Web of Science ®Google Scholar
• May L. D., Lefkowitch J. H., Kram M. T., Rubin D. E. Mixed hepatocellular-cholestatic liver injury after pioglitazone therapy. Ann. Intern. Med. 2002; 136: 449
   PubMed Web of Science ®Google Scholar
• McIntosh C. H.S., Pederson R. A. Noninsulin-dependent animal models of diabetes mellitus. Experimental models of diabetes, J. H. McNeill. CRC Press, Boca Raton, FL 1999; 338
   Google Scholar
• McRobie D. J., Glover D. D., Tracy T. S. Effects of gestational and overt diabetes on human placental cytochromes P450 and glutathione S-transferase. Drug Metab. Dispos. 1998; 26: 367
   PubMed Web of Science ®Google Scholar
• McRobie D. J., Korzekwa K. R., Glover D. D., Tracy T. S. The effects of diabetes on placental aromatase activity. J. Steroid Biochem. Mol. Biol. 1997; 63: 147
   Google Scholar
• Mehendale H. M. Role of hepatocellular regeneration and hepatolobular healing in the final outcome of liver injury. A two stage model of hepatotoxicity. Biochem. Pharmacol. 1991; 42: 1155
   PubMedGoogle Scholar
• Mehendale H. M. Amplified interactive toxicity of chemicals at nontoxic levels: mechanistic considerations and implications to public health. Environ. Health Perspect. 1994; 10: 139
   Google Scholar
• Mehendale H. M. Tissue repair: An important determinant of final outcome of toxicant-induced injury. Toxicol. Pathol. 2005; 33: 41
   PubMed Web of Science ®Google Scholar
• Mehendale H. M., Limaye P. B. Calpain: A death protein that mediates progression of liver injury. Trends Pharmacol. Sci. 2005; 26: 232
   PubMed Web of Science ®Google Scholar
• Mehendale H. M. Role of tissue repair in liver injury. Drug-induced liver disease, 2nd ed., N. Kaplowitz, L. DeLeve. Informa Healthcare, Philadelphia, PA 2007
   Google Scholar
• Mekinova D., Chorvathova V., Volkovova K., Staruchova M., Grancicova E., Klvanova J., Ondreicka R. Effect of intake of exogenous vitamins C, E and beta-carotene on the antioxidative status in kidneys of rats with streptozotocin-induced diabetes. Nahrun 1995; 39: 257
   PubMedGoogle Scholar
• Memon R. A., Tecott L. H., Nonogaki K., Beigneux A., Moser A. H., Grunfeld C., Feingold K. R. Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: Troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice. Endocrinology 2000; 141: 4021
   PubMed Web of Science ®Google Scholar
• Michalopoulos G. K., DeFrances M. C. Liver regeneration. Science 1997; 276: 60
   PubMed Web of Science ®Google Scholar
• Michalopoulos G. K., DeFrances M. C. Liver regeneration. Adv. Biochem. Eng. Biotechnol. 2005; 93: 101
   PubMed Web of Science ®Google Scholar
• Mordes J. P., Rossini A. A. Animal models of diabetes. Am. J. Med. 1981; 70: 353
   PubMed Web of Science ®Google Scholar
• Mukherjee B., Anbazhagan S., Roy A., Ghosh R., Chatterjee M. Novel implications of the potential role of selenium on antioxidant status in streptozotocin-induced diabetic mice. Biomed. Pharmacother. 1998; 52: 89
   PubMed Web of Science ®Google Scholar
• Mukherjee B., Mukherjee J. R., Chatterjee M. Lipid peroxidation, glutathione levels and changes in glutathione-related enzyme activities in streptozotocin-induced diabetic rats. Immuno. Cell Biol. 1994; 72: 109
   PubMed Web of Science ®Google Scholar
• Murphy E. J., Davern T. J., Shakil A. O., Shick L., Masharani U., Chow H., Freise C., Lee W. M., Bass N. M. Troglitazone-induced fulminant hepatic failure. Acute Liver Failure Study Group. Dig. Dis. Sci. 2000; 45: 549
   PubMed Web of Science ®Google Scholar
• Muylle E., van den Hende C., Deprez P., Nuytten J., Oyaert W. Non-insulin dependent diabetes mellitus in a horse. Equine. Vet. J. 1986; 18: 145
   Google Scholar
• Najjar T. A., Saad S. Y. Cisplatin pharmacokinetics and its nephrotoxicity in diabetic rabbits. Chemotherapy 2001; 47: 128
   Google Scholar
• Nakhooda A. F., Like A. A., Chappel C. I., Murray F. T., Marliss E. B. The spontaneously diabetic Wistar rat. Metabolic and morphologic studies. Diabetes 1977; 26: 100
   PubMed Web of Science ®Google Scholar
• Neuschwander-Tetri B. A., Isley W. L., Oki J. C., Ramrakhiani S., Quiason S. G., Phillips N. J., Brunt E. M. Troglitazone-induced hepatic failure leading to liver transplantation. A case report. Ann. Intern. Med. 1998; 129: 38
   PubMed Web of Science ®Google Scholar
• Nicholls-Grzemski F. A., Calder I. C., Priestly B. G. Peroxisome proliferators protect against paracetamol hepatotoxicity in mice. Biochem. Pharmacol. 1992; 43: 1395
   PubMed Web of Science ®Google Scholar
• Nicholls-Grzemski F. A., Calder I. C., Priestly B. G., Burcham P. C. Clofibrate-induced in vitro hepatoprotection against acetaminophen is not due to altered glutathione homeostasis. Toxicol. Sci. 2000; 56: 220
   Google Scholar
• Nishikawa T., Edelstein D., Du X. L., Yamagishi S., Matsumura T., Kaneda Y., Yorek M. A., Beebe D., Oates P. J., Hammes H. P., Giardino I., Brownlee M. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycemic damage. Nature 2000; 404: 787
   PubMed Web of Science ®Google Scholar
• Nishimoto H., Kikutani H., Yamamura K., Kishimoto T. Prevention of autoimmune insulitis by expression of I-E molecules in NOD mice. Nature 1987; 328: 432
   PubMed Web of Science ®Google Scholar
• Nourooz-Zadeh J., Rahimi A., Tajaddini-Sarmadi J., Tritschler H., Rosen P., Halliwell B., Betteridge D. J. Relationships between plasma measures of oxidative stress and metabolic control in NIDDM. Diabetologia 1997; 40: 647
   PubMed Web of Science ®Google Scholar
• Nukatsuka M., Sakurai H., Kawada J. Generation of alloxan free radicals in chemical and biological systems: Implication in the diabetogenic action of alloxan. Biochem. Biophys. Res. Commun. 1989; 165: 278
   Google Scholar
• O'Brien T. D. Pathogenesis of feline diabetes mellitus. Mol. Cell Endocrinol. 2002; 197: 213
   PubMed Web of Science ®Google Scholar
• Okamoto H., Yamamoto H. DNA strand breaks and poly(ADP-ribose) synthetase activation in pancreatic islets—A new aspect to development of insulin-dependent diabetes and pancreatic B-cell tumors. Princess Takamatsu Symp. 1983; 13: 297
   Google Scholar
• Oliver J. R., Jiang S., Cherian M. G. Augmented hepatic injury followed by impaired regeneration in metallothionein-I/II knockout mice after treatment with thioacetamide. Toxicol. Appl. Pharmacol. 2006; 210: 190
   Google Scholar
• Oreskovic K., Kunec-Vajic E. Pseudocholinesterase in alloxan-diabetic rats. Res. Commun. Chem. Pathol. Pharmacol. 1992; 78: 117
   Google Scholar
• Ortiz-Caro J., Gonzalez C., Jolin T. Diurnal variations of plasma growth hormone, thyrotropin, thyroxine, and triiodothyronine in streptozotocin-diabetic and food-restricted rats. Endocrinology 1984; 15: 2227
   Google Scholar
• Otsyula M., King M. S., Ketcham T. G., Sanders R. A., Watkins J. B., 3rd. Oxidative stress in rats after 60 days of hypergalactosemia or hyperglycemia. Int. J. Toxicol. 2003; 22: 423
   PubMedGoogle Scholar
• Ozawa K., Yamada T., Ukikusa M., Ngala K., Ida T., Nakase A., Tobe T. Mitochondrial phosphorylative activity and DNA synthesis in regenerating liver of diabetic rats. J. Surg. Res. 1981; 31: 38
   Google Scholar
• Ozden T. A., Uzun H., Bohloli M., Toklu A. S., Paksoy M., Simsek G., Durak H., Issever H., Ipek T. The effects of hyperbaric oxygen treatment on oxidant and antioxidants levels during liver regeneration in rats. Tohoku J. Exp. Med. 2004; 203: 253
   PubMed Web of Science ®Google Scholar
• Ozdogan M., Ersoy E., Dundar K., Albayrak L., Devay S., Gundogdu H. Beneficial effect of hyperbaric oxygenation on liver regeneration in cirrhosis. J. Surg. Res. 2005; 129: 260
   Google Scholar
• Pachecka J., Kobylinska K., Suchocka Z., Kuczynska J. The effect of short-term alloxan-induced diabetes on the activity of drug metabolizing enzymes. Acta Pol. Pharm. 1993; 50: 435
   Google Scholar
• Panepinto L. M., Phillips R. W., Westmoreland N. W., Cleek J. L. Influence of genetics and diet on the development of diabetes in Yucatan miniature swine. J. Nutr. 1982; 112: 2307
   PubMedGoogle Scholar
• Park J. M., Moon C. H., Lee M. G. Pharmacokinetic changes of methotrexate after intravenous administration to uranyl nitrate-induced acute renal failure rats. Res. Commun. Mol. Pathol. Pharmacol. 1996; 93: 353
   PubMedGoogle Scholar
• Pascal M. M., Forrester J. V., Knott R. M. Glucose-mediated regulation of transforming growth factor-beta (TGF-beta) and TGF-beta receptors in human retinal endothelial cells. Curr. Eye Res. 1999; 19: 162
   PubMed Web of Science ®Google Scholar
• Patel B. N., Mackness M. I., Harty D. W., Arrol S., Boot-Handford R. P., Durrington P. N. Serum esterase activities and hyperlipidaemia in the streptozotocin-diabetic rat. Biochim. Biophys. Acta 1990; 1035: 113
   PubMed Web of Science ®Google Scholar
• Peavy D. E., Taylor J. M., Jefferson L. S. Correlation of albumin production rates and albumin mRNA levels in livers of normal, diabetic, and insulin-treated diabetic rats. Proc. Natl. Acad. Sci. USA 1978; 75: 5879
   PubMed Web of Science ®Google Scholar
• Pekiner B., Ulusu N. N., Das-Evcimen N., Sahilli M., Aktan F., Stefek M., Stolc S., Karasu C. In vivo treatment with stobadine prevents lipid peroxidation, protein glycation and calcium overload but does not ameliorate Ca2 +-ATPase activity in heart and liver of streptozotocin-diabetic rats: Comparison with vitamin E. Biochim. Biophys. Acta 2002; 1588: 71
   PubMed Web of Science ®Google Scholar
• Peters T. S. Do preclinical testing strategies help predict human hepatotoxic potentials?. Toxicologic Pathology 2005; 33: 146
   PubMed Web of Science ®Google Scholar
• Petlevski R., Hadzija M., Slijepcevic M., Juretic D., Petrik J. Glutathione S-transferases and malondialdehyde in the liver of NOD mice on short-term treatment with plant mixture extract P-9801091. Phytother. Res. 2003; 17: 311
   Google Scholar
• Pitkin R. M., Reynolds W. A. Diabetogenic effects of streptozotocin in rhesus monkeys. Diabetes 1970; 19: 85
   PubMed Web of Science ®Google Scholar
• Price V. F., Jollow D. J. Increased resistance of diabetic rats to acetaminophen-induced hepatotoxicity. J. Pharmacol. Exp. Ther. 1982; 220: 504
   PubMed Web of Science ®Google Scholar
• Price V. F., Jollow D. J. Role of UDPGA flux in acetaminophen clearance and hepatotoxicity. Xenobiotica 1984; 14: 553
   PubMed Web of Science ®Google Scholar
• Price V. F., Jollow D. J. Strain differences in susceptibility of normal and diabetic rats to acetaminophen hepatotoxicity. Biochem. Pharmacol. 1986; 35: 687
   PubMedGoogle Scholar
• Pucci L., Chirulli V., Marini S., Lucchesi D., Penno G., Gervasi P. G., Prato S. D., Longo V. Expression and activity of CYP2E1 in circulating lymphocytes are not altered in diabetic individuals. Pharmacol. Res. 2005; 51: 561
   PubMed Web of Science ®Google Scholar
• Qin L. Q., Wang P. Y., Wang Y., Kaneko T., Hoshi K., Sato A. Voglibose potentiates the hepatotoxicity of carbon tetrachloride and acetaminophen by inducing CYP2E1 in rats. Hepatol. Res. 2005; 33: 50
   PubMedGoogle Scholar
• Ramachandran V., Kostrubsky V. E., Komoroski B. J., Zhang S., Dorko K., Esplen J. E., Strom S. C., Venkataramanan R. Troglitazone increases cytochrome P-450 3A protein and activity in primary cultures of human hepatocytes. Drug Metab. Dispos. 1999; 27: 1194
   PubMed Web of Science ®Google Scholar
• Ramaiah S. K., Soni M. G., Bucci T. J., Mehendale H. M. Diet restriction enhances compensatory liver tissue repair and survival following administration of lethal dose of thioacetamide. Toxicol. Appl. Pharmacol. 1998; 150: 12
   Google Scholar
• Rand J. Current understanding of feline diabetes: Part 1, pathogenesis. J. Feline Med. Surg. 1999; 1: 143
   PubMedGoogle Scholar
• Rao P. S., Lyn-Cook B. D., Littlefield N. A., Mehendale H. M. High glucose concentration alters cell proliferation dynamics in human hepatoma cell. Int. J. Toxicol. 1999; 18: 297
   Google Scholar
• Rao C. V., Mehendale H. M. Effect of colchicines on hepatobiliary function in CCl4 treated rats. Biochem. Pharmacol. 1991; 42: 2323
   Google Scholar
• Rao K. N., Virji M. A., Moraca M. A., Diven W. F., Martin T. G., Schneider S. M. Role of serum markers for liver function and liver regeneration in the management of chloroform poisoning. J. Anal. Toxicol. 1993; 17: 99
   PubMed Web of Science ®Google Scholar
• Rauscher F. M., Sanders R. A., Watkins J. B., 3rd. Effects of piperine on antioxidant pathways in tissues from normal and streptozotocin-induced diabetic rats. J. Biochem. Mol. Toxicol. 2000; 14: 329
   PubMed Web of Science ®Google Scholar
• Rauscher F. M., Sanders R. A., Watkins J. B., 3rd. Effects of isoeugenol on oxidative stress pathways in normal and streptozotocin-induced diabetic rats. J. Biochem. Mol. Toxicol. 2001; 15: 159
   PubMed Web of Science ®Google Scholar
• Raza H., Ahmed I., John A., Sharma A. K. Modulation of xenobiotic metabolism and oxidative stress in chronic streptozotocin-induced diabetic rats fed with Momordica charantia fruit extract. J. Biochem. Mol. Toxicol. 2000; 14: 131
   PubMed Web of Science ®Google Scholar
• Raza H., Ahmed I., Lakhani M. S., Sharma A. K., Pallot D., Montague W. Effect of bitter melon (Momordica charantia) fruit juice on the hepatic cytochrome P450-dependent monooxygenases and glutathione S-transferases in streptozotocin-induced diabetic rats. Biochem. Pharmacol. 1996; 52: 1639
   PubMed Web of Science ®Google Scholar
• Raza H., Prabu S. K., Robin M. A., Avadhani N. G. Elevated mitochondrial cytochrome P450 2E1 and glutathione S-transferase A4-4 in streptozotocin-induced diabetic rats: tissue-specific variations and roles in oxidative stress. Diabetes 2004; 53: 185
   PubMed Web of Science ®Google Scholar
• Reed M. J., Meszaros K., Entes L. J., Claypool M. D., Pinkett J. G., Gadbois T. M., Reaven G. M. A new rat model of type 2 diabetes: The fat-fed, streptozotocin-treated rat. Metabolism 2000; 49: 1390
   PubMed Web of Science ®Google Scholar
• Richter C. Do mitochondrial DNA fragments promote cancer and aging?. FEBS Lett. 1988; 241: 1
   PubMed Web of Science ®Google Scholar
• Richter C. Reactive oxygen and DNA damage in mitochondria. Mutat. Res. 1992; 275: 249
   PubMed Web of Science ®Google Scholar
• Richter C., Park J. W., Ames B. N. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc. Natl. Acad. Sci. USA 1988; 85: 6465
   PubMed Web of Science ®Google Scholar
• Rifik H., Porte D. Ellenberg and Rifkin's diabetes mellitus: Theory and practice, 4th ed. Appleton and Lange, Columbus, OH 1990
   Google Scholar
• Rolandsson O., Haney M. F., Hagg E., Biber B., Lernmark A. Streptozotocin induced diabetes in minipig: A case report of a possible model for type 1 diabetes?. Autoimmunity 2002; 35: 261
   Web of Science ®Google Scholar
• Roman R. M., Fitz J. G. Emerging roles of purinergic signaling in gastrointestinal epithelial secretion and hepatobiliary function. Gastroenterology 1999; 116: 964
   PubMed Web of Science ®Google Scholar
• Ronco M. T., Alvarez M. L., Monti J., Carrillo M. C., Pisani G., Lugano M. C., Carnovale C. E. Modulation of balance between apoptosis and proliferation by lipid peroxidation during rat liver regeneration. Mol. Med. 2002; 8: 808
   PubMed Web of Science ®Google Scholar
• Rosen P., Nawroth P. P., King G., Moller W., Tritschler H. J., Packer L. The role of oxidative stress in the onset and progression of diabetes and its complications: A summary of the congress series sponsored by UNESCO-MCBN, the American diabetes association and the German diabetes society. Diabetes Metab. Res. Rev. 2001; 17: 189
   PubMed Web of Science ®Google Scholar
• Roth S. I., Conaway H. H., Sanders L. L., Casali R. E., Boyd A. E., 3rd. Spontaneous diabetes mellitus in the New Zealand white rabbit: Preliminary morphologic characterization. Lab. Invest. 1980; 42: 571
   Google Scholar
• Rouer E., Mahu J. L., Dansette P., Leroux J. P. UDP-glucuronosyltransferase, epoxide hydrolase and glutathione S-transferase activities in the liver of diabetic mice. Biochim. Biophys. Acta 1981; 676: 274
   Google Scholar
• Rouer E., Mahu J. L., Columelli S., Dansette P., Leroux J. P. Induction of drug metabolizing enzymes in the liver of diabetic mice. Biochimie 1982; 64: 961
   Google Scholar
• Rouer E., Leroux J. P. Liver microsomal cytochrome P-450 and related monooxygenase activities in genetically hyperglycemic (ob/ob and db/db) and lean streptozotocin-treated mice. Biochem. Pharmacol. 1980; 29: 1959
   Google Scholar
• Rouer E., Rouet P., Delpech M., Leroux J. P. Purification and comparison of liver microsomal flavin-containing monooxygenase from normal and streptozotocin-diabetic rats. Biochem. Pharmacol. 1988; 18: 3455
   Google Scholar
• Rozga J. Hepatocyte proliferation in health and in liver failure. Med. Sci. Monit. 2002; 8: RA32
   Google Scholar
• Ruiz C., Alegria A., Barbera R., Farre R., Lagarda M. J. Lipid peroxidation and antioxidant enzyme activities in patients with type 1 diabetes mellitus. Scand. J. Clin. Lab. Invest. 1999; 59: 99
   PubMed Web of Science ®Google Scholar
• Ruoff W. W., Baker D. C., Morgan S. J., Abbitt B. Type II diabetes mellitus in a horse. Equine Vet. J. 1986; 18: 143
   Google Scholar
• Runge-Morris M., Vento C. Effects of streptozotocin-induced diabetes on rat liver sulfotransferase gene expression. Drug Metab. Dispos. 1995; 23: 455
   Google Scholar
• Sahi J., Hamilton G., Sinz M., Barros S., Huang S. M., Lesko L. J., LeCluyse E. L. Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes. Xenobiotica 2000; 30: 273
   PubMed Web of Science ®Google Scholar
• Sailaja Y. R., Baskar R., Saralakumari D. The antioxidant status during maturation of reticulocytes to erythrocytes in type 2 diabetics. Free Radical Biol. Med. 2003; 35: 133
   PubMed Web of Science ®Google Scholar
• Sakuma T., Honma R., Maguchi S., Tamaki H., Nemoto N. Different expression of hepatic and renal cytochrome P450s between the streptozotocin-induced diabetic mouse and rat. Xenobiotica 2001; 31: 223
   PubMed Web of Science ®Google Scholar
• Santini S. A., Marra G., Giardina B., Cotroneo P., Mordente A., Martorana G. E., Manto A., Ghirlanda G. Defective plasma antioxidant defenses and enhanced susceptibility to lipid peroxidation in uncomplicated IDDM. Diabetes 1997; 46: 1853
   PubMed Web of Science ®Google Scholar
• Sawant S. P., Dnyanmote A. V., Shankar K., Limaye P. B., Latendresse J. R., Mehendale H. M. Potentiation of carbon tetrachloride hepatotoxicity and lethality in type 2 diabetic rats. J. Pharmacol. Exp. Ther. 2004; 308: 694
   PubMed Web of Science ®Google Scholar
• Sawant S. P., Dnyanmote A. V., Mitra M. S., Chilakapati J., Warbritton A., Latendresse J. R., Mehendale H. M. Protective effect of type 2 diabetes on acetaminophen-induced hepatotoxicity in male Swiss Webster mice. J. Pharmacol. Exp. Ther. 2006a; 316: 507
   Google Scholar
• Sawant S. P., Dnyanmote A. V., Warbritton A., Latendresse J. R., Mehendale H. M. Type 2 diabetic rats are sensitive to thioacetamide hepatotoxicity. Toxicol. Appl. Pharmacol. 2006b; 211: 221
   Google Scholar
• Sawant S. P., Dnyanmote A. V., Mehendale H. M. Mechanism of inhibited liver tissue repair in toxicant challenged type 2 diabetic rats. Toxicology 2007; 232: 200
   Google Scholar
• Scheen A. J. Hepatotoxicity with thiazolidinediones: Is it a class effect?. Drug Safety 2001; 24: 873
   PubMedGoogle Scholar
• Schmidt L. K., Dallhoff K. Alpha-fetoprotein as a predictor of outcome in acetaminoiphen-induced liver injury. Hepatology 2005; 41: 26–31
   PubMed Web of Science ®Google Scholar
• Schnedl W. J., Ferber S., Johnson J. H., Newgard C. B. Streptozotocin transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells. Diabetes 1994; 43: 1326
   PubMed Web of Science ®Google Scholar
• Schrauwen P., Hesselink M. K. Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes. Diabetes 2004; 53: 1412
   PubMed Web of Science ®Google Scholar
• Schwabe R. F., Bradham C. A., Uehara T., Hatano E., Bennett B. L., Schoonhoven R., Brenner D. A. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology 2003; 37: 824
   PubMed Web of Science ®Google Scholar
• Shankar K., Vaidya V. S., Wang T., Bucci T. J., Mehendale H. M. Streptozotocin-induced diabetic mice are resistant to lethal effects of thioacetamide hepatotoxicity. Toxicol. Appl. Pharmacol. 2003a; 188: 122
   PubMed Web of Science ®Google Scholar
• Shankar K., Vaidya V. S., Apte U. M., Manautou J. E., Bucci T. J., Ronis M. J., Mehendale H. M. Type I diabetic mice are protected from acetaminophen hepatotoxicity. Toxicol. Sci. 2003b; 73: 220
   Google Scholar
• Shankar K., Vaidya V. S., Corton J. C., Bucci T. J., Liu J., Waalkes M. P., Mehendale H. M. Activation of PPAR-alpha in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity. FASEB J. 2003c; 17: 1748
   PubMedGoogle Scholar
• Sharma A. D., Cantz T., Richter R., Eckert K., Henschler R., Wilkens L., Jochheim-Richter A., Arseniev L., Ott M. Human cord blood stem cells generate human cytokeratin 18-negative hepatocyte-like cells in injured mouse liver. Am. J. Pathol. 2005; 167: 555
   PubMedGoogle Scholar
• Shayiq R. M., Roberts D. W., Rothstein K., Snawder J. E., Benson W., Ma X., Black M. Repeat exposure to incremental doses of acetaminophen provides protection against acetaminophen-induced lethality in mice: an explanation for high acetaminophen dosage in humans without hepatic injury. Hepatology 1999; 29: 451
   PubMed Web of Science ®Google Scholar
• Sheweita S. A., Newairy A. A., Mansour H. A., Yousef M. I. Effect of some hypoglycemic herbs on the activity of phase I and II drug-metabolizing enzymes in alloxan-induced diabetic rats. Toxicology 2002; 174: 131
   PubMed Web of Science ®Google Scholar
• Shibuya A., Watanabe M., Fujita Y., Saigenji K., Kuwao S., Takahashi H., Takeuchi H. An autopsy case of troglitazone-induced fulminant hepatitis. Diabetes Care 1998; 21: 2140
   PubMed Web of Science ®Google Scholar
• Shimojo N. Cytochrome P450 changes in rats with streptozocin-induced diabetes. Int. J. Biochem. 1994; 26: 1261
   PubMedGoogle Scholar
• Shimojo N., Ishizaki T., Imaoka S., Funae Y., Fujii S., Okuda K. Changes in amounts of cytochrome P450 isozymes and levels of catalytic activities in hepatic and renal microsomes of rats with streptozotocin-induced diabetes. Biochem. Pharmacol. 1993; 46: 621
   PubMed Web of Science ®Google Scholar
• Sidhu J. S., Liu F., Boyle S. M., Omiecinski C. J. PI3K inhibitors reverse the suppressive actions of insulin on CYP2E1 expression by activating stress-response pathways in primary rat hepatocytes. Mol. Pharmacol. 2001; 59: 1138
   PubMedGoogle Scholar
• Siegmund B., Lear-Kaul K. C., Faggioni R., Fantuzzi G. Leptin deficiency, not obesity, protects mice from Con A-induced hepatitis. Eur. J. Immunol. 2002; 32: 552
   Google Scholar
• Sima A., Shafrir E. Animal models of diabetes: A primer. Overseas Publishers Association, Amsterdam 2001
   Google Scholar
• Simek J., Chmelar V., Melka J., Pazderka J., Charvat Z. Influence of protracted infusion of glucose and insulin on the composition and regeneration activity of liver after partial hepatectomy in rats. Nature 1967; 213: 910
   Google Scholar
• Simon J., Dubois M. P. Failure of a sublethal streptozotocin dose to induce diabetes in the chicken. Horm. Metab. Res. 1980; 12: 631
   PubMed Web of Science ®Google Scholar
• Sitbon G., Laurent F., Mialhe A., Krug E., Karmann H., Gross R., Strosser M. T., Cohen L., Jean-Marie P., Foltzer C., Mialhe P. Diabetes in birds. Horm. Metab. Res. 1980; 12: 1
   PubMed Web of Science ®Google Scholar
• Skrha J., Hodinar A., Kvasnicka J., Hilgertova J. Relationship of oxidative stress and fibrinolysis in diabetes mellitus. Diabet. Med. 1996; 13: 800
   Google Scholar
• Song B. J., Veech R. L., Saenger P. Cytochrome P450IIE1 is elevated in lymphocytes from poorly controlled insulin-dependent diabetics. J. Clin. Endocrinol. Metab. 1990; 71: 1036
   PubMed Web of Science ®Google Scholar
• Soni M. G., Ramaiah S. K., Mumtaz M. M., Clewell H., Mehendale H. M. Toxicant-inflicted injury and stimulated tissue repair are opposing toxicodynamic forces in predictive toxicology. Regul. Toxicol. Pharmacol. 1999; 29: 165
   PubMed Web of Science ®Google Scholar
• Sotaniemi E. A., Pelkonen O., Arranto A. J., Tapanainen P., Rautio A., Pasanen M. Diabetes and elimination of antipyrine in man: An analysis of 298 patients classified by type of diabetes, age, sex, duration of disease and liver involvement. Pharmacol. Toxicol. 2002; 90: 155
   PubMedGoogle Scholar
• Starzl T. E., Francavilla A., Halgrimson C. G., Francavilla F. R., Porter K. A., Brown T. H., Putnam C. W. The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood. Surg. Gynecol. Obstet. 1973; 137: 179
   PubMedGoogle Scholar
• Steiner D. F., King J. Insulin-stimulated ribonucleic acid synthesis and RNA polymerase activity in alloxan-diabetic rat liver. Biochim. Biophys. Acta 1966; 119: 510
   Google Scholar
• Stogdale L. Definition of diabetes mellitus. Cornell Vet. 1986; 76: 156
   Google Scholar
• Stralfors P. Insulin second messengers. Bioessays 1997; 19: 327
   PubMed Web of Science ®Google Scholar
• Stumvoll M., Haring H. U. Glitazones: clinical effects and molecular mechanisms. Ann. Med. 2002; 34: 217
   PubMed Web of Science ®Google Scholar
• Suchocka Z., Kobylinska K., Pachecka J. Activity of glutathione-dependent enzymes in long term diabetes. I. Activity of glutathione S-transferase and glutathione peroxidase in the liver of alloxan induced diabetic rats. Acta Pol. Pharm. 1995; 52: 207
   Google Scholar
• Swamy-Mruthinti S., Shaw S. M., Zhao H. R., Green K., Abraham E. C. Evidence of a glycemic threshold for the development of cataracts in diabetic rats. Curr. Eye Res. 1999; 18: 423
   PubMed Web of Science ®Google Scholar
• Takada H., Uchida A., Kamizono R., Otagiri M., Imamura Y. Further studies on 20beta-hydroxysteroid dehydrogenase with carbonyl reductase-like activity present in liver microsomes of male rats. Life Sci. 2000; 67: 2075
   Google Scholar
• Takasu N., Komiya I., Asawa T., Nagasawa Y., Yamada T. Streptozocin-and alloxan-induced H2O2 generation and DNA fragmentation in pancreatic islets. H2O2 as mediator for DNA fragmentation. Diabetes 1991; 40: 1141
   PubMed Web of Science ®Google Scholar
• Tang P. M., Finkelstein J. A., Chiang J. Y. Expression of hepatic microsomal cholesterol 7 alpha-hydroxylase activity in lean and obese Zucker rats. Biochem. Biophys. Res. Commun. 1988; 150: 853
   Google Scholar
• Taniyama H., Shirakawa T., Furuoka H., Osame S., Kitamura N., Miyazawa K. Spontaneous diabetes mellitus in young cattle: Histologic, immunohistochemical, and electron microscopic studies of the islets of Langerhans. Vet. Pathol. 1993; 30: 46
   Google Scholar
• Taniyama H., Hirayama K., Kagawa Y., Kurosawa T., Tajima M., Yoshino T., Furuoka H. Histopathological and immunohistochemical analysis of the endocrine and exocrine pancreas in twelve cattle with insulin-dependent diabetes mellitus (IDDM). J. Vet. Med. Sci. 1999; 61: 803
   PubMed Web of Science ®Google Scholar
• Taub R. Hepatoprotection via the IL-6/Stat3 pathway. J. Clin. Invest. 2003; 112: 978
   PubMed Web of Science ®Google Scholar
• Tannenbaum G. S. Growth hormone secretory dynamics in streptozotocin diabetes: Evidence of a role for endogenous circulating somatostatin. Endocrinology 1981; 108: 76
   PubMed Web of Science ®Google Scholar
• Thakore K. N., Mehendale H. M. Role of hepatocellular regeneration in CCl4 autoprotection. Toxicol. Pathol. 1991; 19: 47
   PubMed Web of Science ®Google Scholar
• Theriault B. R., Thistlethwaite J. R., Jr., Levisetti M. G., Wardrip C. L., Szot G., Bruce D. S., Rilo H., Li X., Gray G. S., Bluestone J. A., Padrid P. A. Induction, maintenance, and reversal of streptozotocin-induced insulin-dependent diabetes mellitus in the juvenile cynomolgus monkey (Macaca fascilularis). Transplantation 1999; 68: 331
   PubMed Web of Science ®Google Scholar
• Thevananther S., Sun H., Li D., Arjunan V., Awad S. S., Wyllie S., Zimmerman T. L., Goss J. A., Karpen S. J. Extracellular ATP activates c-jun N-terminal kinase signaling and cell cycle progression in hepatocytes. Hepatology 2004; 39: 393
   Google Scholar
• Thomas H., Schladt L., Knehr M., Oesch F. Effect of diabetes and starvation on the activity of rat liver epoxide hydrolases, glutathione S-transferases and peroxisomal beta-oxidation. Biochem. Pharmacol. 1989; 38: 4291
   PubMed Web of Science ®Google Scholar
• Thompson N. L., Mead J. E., Braun L., Goyette M., Shank O. R., Fausto N. Sequential protooncogene expression during rat liver regeneration. Cancer Res. 1986; 46: 3111
   PubMed Web of Science ®Google Scholar
• Thummel K. E., Schenkman J. B. Effects of testosterone and growth hormone treatment on hepatic microsomal P450 expression in the diabetic rat. Mol. Pharmacol. 1990; 37: 119
   PubMed Web of Science ®Google Scholar
• Tofovic S. P., Jackson E. K. Rat models of the metabolic syndrome. Methods Mol. Med. 2003; 86: 29
   PubMedGoogle Scholar
• Toleikis P. M., Godin D. V. Alteration of antioxidant status in diabetic rats by chronic exposure to psychological stressors. Pharmacol. Biochem. Behav. 1995; 52: 355
   Google Scholar
• Torbenson M., Yang S. Q., Liu H. Z., Huang J., Gage W., Diehl A. M. STAT-3 overexpression and p21 up-regulation accompany impaired regeneration of fatty livers. Am. J. Pathol. 2002; 161: 155
   Google Scholar
• Traverso N., Menini S., Odetti P., Pronzato M. A., Cottalasso D., Marinari U. M. Diabetes impairs the enzymatic disposal of 4-hydroxynonenal in rat liver. Free Radical Biol. Med. 2002; 32: 350
   PubMed Web of Science ®Google Scholar
• Truett G. E., Bahary N., Friedman J. M., Leibel R. L. Rat obesity gene fatty (fa) maps to chromosome 5: evidence for homology with the mouse gene diabetes (db). Proc. Natl. Acad. Sci. USA 1991; 88: 7806
   PubMed Web of Science ®Google Scholar
• Tsiani E., Lekas P., Fantus I. G., Dlugosz J., Whiteside C. High glucose-enhanced activation of mesangial cell p38 MAPK by ET-1, ANG II, and platelet-derived growth factor. Am. J. Physiol. Endocrinol. Metab. 2002; 282: E161
   Google Scholar
• Tuntaterdtum S., Chaudhary I. P., Cibull M., Robertson L. W., Blouin R. A. Acetaminophen hepatotoxicity: influence of phenobarbital and beta-naphthoflavone treatment in obese and lean Zucker rats. Toxicol. Appl. Pharmacol. 1993; 123: 219
   Google Scholar
• Turmelle Y. P., Shikapwashya O., Tu S., Hruz P. W., Yan Q., Rudnick D. A. Rosiglitazone inhibits mouse liver regeneration. FASEB J. 2006; 20: 2609
   Google Scholar
• Uphues I., Kolter T., Goud B., Eckel J. Failure of insulin-regulated recruitment of the glucose transporter GLUT4 in cardiac muscle of obese Zucker rats is associated with alterations of small-molecular-mass GTP-binding proteins. Biochem. J. 1995; 311: 161
   PubMedGoogle Scholar
• VanderJagt D. J., Harrison J. M., Ratliff D. M., Hunsaker L. A., VanderJagt D. L. Oxidative stress indices in IDDM subjects with and without long-term diabetic complications. Clin. Biochem. 2001; 34: 265
   PubMedGoogle Scholar
• Vega P., Gaule C., Mancilla J., del Villar E. Comparison of alloxan and streptozotocin induced diabetes in rats: Differential effects on microsomal drug metabolism. Gen. Pharmacol. 1993; 24: 489
   Google Scholar
• Vega P., Gaule C., Sanchez E., del Villar E. Inhibition and activation of UDP-glucuronyltransferase in alloxanic-diabetic rats. Gen. Pharmacol. 1986; 17: 641
   Google Scholar
• Virji M. A., Venkataraman S. T., Lower D. R., Rao K. N. Role of laboratory in the management of phenylbutazone poisoning. J. Toxicol. Clin. Toxicol. 2003; 41: 1013
   PubMed Web of Science ®Google Scholar
• Von Mehring J., Minkowski J. diabetes mellitus nach pankresexstirpation. Arch. Exp. Path. 1890; 26: 371
   Google Scholar
• Wagner J. D., Cline J. M., Shadoan M. K., Bullock B. C., Rankin S. E., Cefalu W. T. Naturally occurring and experimental diabetes in cynomolgus monkeys: A comparison of carbohydrate and lipid metabolism and islet pathology. Toxicol. Pathol. 2001; 29: 142
   Google Scholar
• Wang T., Fonetenot R. D., Soni M. G., Bucci T. J., Mehendale H. M. Enhanced hepatotoxicity and toxic outcome of thioacetamide in streptozotocin-induced diabetic rats. Toxicol. Appl. Pharmacol. 2000a; 166: 92
   PubMed Web of Science ®Google Scholar
• Wang T., Shankar K., Ronis M. J., Mehendale H. M. Potentiation of thioacetamide liver injury in diabetic rats is due to induced CYP2E1. J. Pharmacol. Exp. Ther. 2000b; 294: 473
   PubMed Web of Science ®Google Scholar
• Wang T., Shankar K., Bucci T. J., Warbritton A., Mehendale H. M. Diallyl Sulfide inhibition of CYP2E1 does not rescue diabetic rats from thioacetamide-induced mortality. Toxicol. Appl. Pharmacol. 2001; 173: 27
   PubMed Web of Science ®Google Scholar
• Wang X., Hung N. J., Costa R. H. Earlier expression of the transcription factor HFH-11B diminishes induction of p21(CIP1/WAF1) levels and accelerates mouse hepatocyte entry into S-phase following carbon tetrachloride liver injury. Hepatology 2001; 33: 1404
   PubMed Web of Science ®Google Scholar
• Wang Z., Hall S. D., Maya J. F., Li L., Asghar A., Gorski J. C. Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1 in humans. Br. J. Clin. Pharmacol. 2003; 55: 77
   PubMed Web of Science ®Google Scholar
• Watanabe T., Furukawa T., Sharyo S., Ohashi Y., Yasuda M., Takaoka M., Manabe S. Effect of troglitazone on the liver of a Gunn rat model of genetic enzyme polymorphism. J. Toxicol. Sci. 2000; 25: 423
   Google Scholar
• Watkins J. B., 3rd, Klueber K. M. Hepatic phase II biotransformation in C57Bl/KsJ db/db mice: comparison to that in Swiss Webster and 129 REJ mice. Comp. Biochem. Physiol. C. 1988; 90: 417
   Google Scholar
• Watkins J. B., 3rd, Sanders R. A. Diabetes mellitus-induced alteration of hepatobiliary functions. Pharmacol. Rev. 1995; 47: 1
   Google Scholar
• Watkins J. B., 3rd, Sanders R. A., Beck L. V. The effect of long-term streptozotocin-induced diabetes on the hepatotoxicity of bromobenzene and carbon tetrachloride and hepatic biotransformation in rats. Toxicol. Appl. Pharmacol. 1988; 93: 329
   PubMed Web of Science ®Google Scholar
• Watkins J. B., 3rd, Sherman S. E. Long-term diabetes alters the hepatobiliary clearance of acetaminophen, bilirubin and digoxin. J. Pharmacol. Exp. Ther. 1992; 260: 1337
   PubMedGoogle Scholar
• Watkins P. B. Idiosyncratic liver injury: Challenges and approaches. Toxicol. Pathol. 2005a; 33: 1
   PubMed Web of Science ®Google Scholar
• Watkins P. B. Insight into hepatotoxicity: The troglitazone experience. Hepatology 2005b; 41: 229
   PubMed Web of Science ®Google Scholar
• Watkins P. B., Whitcomb R. W. Hepatic dysfunction associated with troglitazone. N. Engl. J. Med. 1998; 338: 916
   PubMed Web of Science ®Google Scholar
• Webber E. M., Bruix J., Pierce R. H., Fausto N. Tumor necrosis factor primes hepatocytes for DNA replication in the rat. Hepatology 1998; 28: 1226
   PubMed Web of Science ®Google Scholar
• Webber E. M., Godowski P. J., Fausto N. In vivo response of hepatocytes to growth factors requires an initial priming stimulus. Hepatology 1994; 14: 489
   Google Scholar
• Weide L. G., Lacy P. E. Low-dose streptozocin-induced autoimmune diabetes in islet transplantation model. Diabetes 1991; 40: 1157
   Google Scholar
• West I. C. Radicals and oxidative stress in diabetes. Diabetic Med. 2000; 17: 171
   PubMed Web of Science ®Google Scholar
• Wilkinson M. G., Millar J. B. Control of the eukaryotic cell cycle by MAP kinase signaling pathways. FASEB J. 2000; 14: 2147
   PubMed Web of Science ®Google Scholar
• Wilson G. L., Patton N. J., McCord J. M., Mullins D. W., Mossman B. T. Mechanisms of streptozotocin-and alloxan-induced damage in rat B cells. Diabetologia 1984; 27: 587
   PubMed Web of Science ®Google Scholar
• Woodcroft K. J., Hafner M. S., Novak R. F. Insulin signaling in the transcriptional and posttranscriptional regulation of CYP2E1 expression. Hepatology 2002; 35: 263
   PubMed Web of Science ®Google Scholar
• Xi S., Yin W., Wang Z., Kusunoki M., Lian X., Koike T., Fan J., Zhang Q. A minipig model of high-fat/high-sucrose diet-induced diabetes and atherosclerosis. Int. J. Exp. Pathol. 2004; 85: 223
   Google Scholar
• Yamada Y., Fausto N. Deficient liver regeneration after carbon tetrachloride injury in mice lacking type 1 but not type 2 tumor necrosis factor receptor. Am. J. Pathol. 1998; 152: 1577
   PubMed Web of Science ®Google Scholar
• Yamada Y., Kirillova I., Peschon J. J., Fausto N. Initiation of liver growth by tumor necrosis factor: Deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. Proc. Natl. Acad. Sci. USA 1997; 94: 1441
   PubMed Web of Science ®Google Scholar
• Yamada T., Yamamoto M., Ozawa K., Honjo I. Insulin requirements for hepatic regeneration following hepatectomy. Ann. Surg. 1977; 185: 35
   Google Scholar
• Yamaguchi M., Kuzume M., Matsumoto T., Shimura H., Matsumiya A., Nakano H., Takeda M., Sanada Y., Kumada K. Adenovirus-mediated insulin gene transfer improves nutritional and post-hepatectomized conditions in diabetic rats. Surgery 2000; 127: 670
   Google Scholar
• Yamamoto H., Uchigata Y., Okamoto H. Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets. Nature 1981; 294: 284
   PubMed Web of Science ®Google Scholar
• Yamasaki H., Saibara T., Maeda T., Onishi S. The arterial ketone body ratio and serum alpha-fetoprotein level in patients with acute hepatic failure. Liver 1995; 15: 219
   PubMedGoogle Scholar
• Yamazaki H., Shibata A., Suzuki M., Nakajima M., Shimada N., Guengerich F. P., Yokoi T. Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes. Drug Metab. Dispos. 1999; 27: 1260
   PubMed Web of Science ®Google Scholar
• Yamazoe Y., Mrayama N., Shimada M., Yamauchi K., Kato R. Cytochrome P450 in livers of diabetic rats: Regulation by growth hormone and insulin. Arch. Biochem. Biophys. 1989; 268: 567
   PubMed Web of Science ®Google Scholar
• Yamazoe Y., Ling X., Murayama N., Gong D., Nagata K., Kato R. Modulation of hepatic level of microsomal testosterone 7 alpha-hydroxylase, P-450a (P450IIA), by thyroid hormone and growth hormone in rat liver. J. Biochem. (Tokyo) 1990; 108: 599
   PubMed Web of Science ®Google Scholar
• Yanardag R., Ozsoy-Sacan O., Orak H., Ozgey Y. Protective effects of glurenorm (gliquidone) treatment on the liver injury of experimental diabetes. Drug Chem. Toxicol. 2005; 28: 483
   PubMed Web of Science ®Google Scholar
• Yang S. Q., Lin H. Z., Mandal A. K., Huang J., Diehl A. M. Disrupted signaling and inhibited regeneration in obese mice with fatty livers: Implications for nonalcoholic fatty liver disease pathophysiology. Hepatology 2001; 34: 694
   PubMed Web of Science ®Google Scholar
• Yang S. Q., Lin H. Z., Lane M. D., Clemens M., Diehl A. M. Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis. Proc. Natl. Acad. Sci. USA 1997; 94: 2557
   PubMed Web of Science ®Google Scholar
• Yen T. T., Gill A. M., Frigeri L. G., Barsh G. S., Wolff G. L. Obesity, diabetes, and neoplasia in yellow Avy mice: Ectopic expression of the agouti gene. FASEB. J. 1994; 8: 479
   Google Scholar
• Yin W., Liao D., Kusunoki M., Xi S., Tsutsumi K., Wang Z., Lian X., Koike T., Fan J., Yang Y., Tang C. NO-1886 decreases ectopic lipid deposition and protects pancreatic beta cells in diet-induced diabetic swine. J. Endocrinol. 2004; 180: 399
   Google Scholar
• Younger L. R., King J., Steiner D. F. Hepatic proliferative response to insulin in severe alloxan diabetes. Cancer Res. 1966; 26: 1408
   Google Scholar
• Yoshigae Y., Konno K., Takasaki W., Ikeda T. Characterization of UDP-glucuronosyltransferases (UGTS) involved in the metabolism of troglitazone in rats and humans. J. Toxicol. Sci. 2000; 25: 433
   PubMedGoogle Scholar
• Yoshinari K., Takagi S., Sugatani J., Miwa M. Changes in the expression of cytochromes P450 and nuclear receptors in the liver of genetically diabetic db/dbmice. Biol. Pharm. Bull. 2006; 29: 1634
   PubMed Web of Science ®Google Scholar
• Zaluzny L., Farrell G. C., Murray M. Effect of genetic obesity and experimental diabetes on hepatic microsomal mixed function oxidase activities. J. Gastroenterol. Hepatol. 1990; 5: 256
   Google Scholar
• Zannikos P. N., Bandyopadhyay A. M., Robertson L. W., Blouin R. A. Cytochrome P450 2B enzyme induction defect after 2,2′,4,4′,5,5′-hexachlorobiphenyl treatment in the fa/fa Zucker rat. J. Pharmacol. Exp. Ther. 1994; 268: 1565
   Google Scholar
• Zemel M. B., Kim J. H., Woychik R. P., Michaud E. J., Kadwell S. H., Patel I. R., Wilkison W. O. Agouti regulation of intracellular calcium: Role in the insulin resistance of viable yellow mice. Proc. Natl. Acad. Sci. USA 1995; 92: 4733
   PubMed Web of Science ®Google Scholar
• Ziegler D. M. Microsomal flavin-containing monooxygenases: Oxygen of nucleophilic nitrogen and sulfur compounds. Enzymatic basis of detoxication, W. B. Jacoby. Academic Press, New York 1980; 201
   Google Scholar
• Zimmers T. A., McKillop I. H., Pierce R. H., Yoo J. Y., Koniaris L. G. Massive liver growth in mice induced by systemic interleukin 6 administration. Hepatology 2003; 38: 326
   PubMed Web of Science ®Google Scholar