Review on the use of zebrafish embryos to study the effects of anesthetics during early development

References

• Aguirre J, Borgeat A, Hasler M, Buhler P, Bonvini JM. 2016. Clinical concentrations of morphine are cytotoxic on proliferating human fibroblasts in vitro. Eur J Anaesthesiol. 33:832–839.
   PubMed Web of Science ®Google Scholar
• Alderton W, Berghmans S, Butler P, Chassaing H, Fleming A, Golder Z, Richards F, Gardner I. 2010. Accumulation and metabolism of drugs and CYP probe substrates in zebrafish larvae. Xenobiotica 40:547–557.
   PubMed Web of Science ®Google Scholar
• Ali S, Champagne DL, Spaink HP, Richardson MK. 2011. Zebrafish embryos and larvae: a new generation of disease models and drug screens. Birth Defects Res C Embryo Today. 93:115–133.
   PubMedGoogle Scholar
• Ali S, van Mil HG, Richardson MK. 2011. Large-scale assessment of the zebrafish embryo as a possible predictive model in toxicity testing. PLoS One. 6:e21076.
   PubMed Web of Science ®Google Scholar
• Allaert SE, Carlier SP, Weyne LP, Vertommen DJ, Dutre PE, Desmet MB. 2007. First trimester anesthesia exposure and fetal outcome. A review. Acta Anaesthesiol Belg. 58:119–123.
   PubMedGoogle Scholar
• Andropoulos DB. 2018. Effect of anesthesia on the developing brain: infant and fetus. Fetal Diagn Ther. 43:1–11.
   PubMed Web of Science ®Google Scholar
• Andropoulos DB, Greene MF. 2017. Anesthesia and developing brains - implications of the FDA warning. N Engl J Med. 376:905–907.
   PubMed Web of Science ®Google Scholar
• Appel B. 2000. Zebrafish neural induction and patterning. Dev Dyn. 219:155–168.
   PubMed Web of Science ®Google Scholar
• Babb M, Koren G, Einarson A. 2010. Treating pain during pregnancy. Can Fam Phys. 56:25–27.
   Web of Science ®Google Scholar
• Bang A, Gronkjaer P, Malte H. 2004. Individual variation in the rate of oxygen consumption by zebrafish embryos. J Fish Biol. 64:1285–1296.
   Web of Science ®Google Scholar
• Bao W, Volgin AD, Alpyshov ET, Friend AJ, Strekalova TV, de Abreu MS, Collins C, Amstislavskaya TG, Demin KA, Kalueff AV. 2019. Opioid neurobiology, neurogenetics and neuropharmacology in zebrafish. Neuroscience. 404:218–232.
   PubMed Web of Science ®Google Scholar
• Barros TP, Alderton WK, Reynolds HM, Roach AG, Berghmans S. 2008. Zebrafish: an emerging technology for in vivo pharmacological assessment to identify potential safety liabilities in early drug discovery. Br J Pharmacol. 154:1400–1413.
   PubMed Web of Science ®Google Scholar
• Blayney MR, Ryan JD, Malins AF. 2003. Propofol target-controlled infusions for sedation–a safe technique for the non-anaesthetist? Br Dent J. 194:450–452.
   PubMed Web of Science ®Google Scholar
• Bovill JG, Sebel PS, Stanley TH. 1984. Opioid analgesics in anesthesia: with special reference to their use in cardiovascular anesthesia. Anesthesiology 61:731–755.
   PubMed Web of Science ®Google Scholar
• Brambrink AM, Evers AS, Avidan MS, Farber NB, Smith DJ, Zhang X, Dissen GA, Creeley CE, Olney JW. 2010. Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain. Anesthesiology. 112:834–841.
   PubMed Web of Science ®Google Scholar
• Bugel SM, Tanguay RL, Planchart A. 2014. Zebrafish: a marvel of high-throughput biology for 21st century toxicology. Curr Environ Health Rep. 1:341–352.
   PubMedGoogle Scholar
• Burgess HA, Granato M. 2007. Sensorimotor gating in larval zebrafish. J Neurosci. 27:4984–4994.
   PubMed Web of Science ®Google Scholar
• Carr RL, Chambers JE. 2001. Toxic responses of the nervous system. In: Schlenk E, Benson, W. H., editors. Target organ toxicity in marine and freshwater teleosts, Taylor and Francis; p. 26–95.
   Google Scholar
• Carvalho O, Gonçalves C. 2011. Comparative physiology of the respiratory system in the animal kingdom. TOBIO J. 4:35–46.
   Google Scholar
• Coimbra AM, Peixoto MJ, Coelho I, Lacerda R, Carvalho AP, Gesto M, Lyssimachou A, Lima D, Soares J, Andre A, et al. 2015. Chronic effects of clofibric acid in zebrafish (Danio rerio): a multigenerational study. Aquat Toxicol. 160:76–86.
   PubMed Web of Science ®Google Scholar
• Cottrell JE, Hartung J. 2012. Developmental disability in the young and postoperative cognitive dysfunction in the elderly after anesthesia and surgery: do data justify changing clinical practice? Mt Sinai J Med. 79:75–94.
   PubMedGoogle Scholar
• Cox B, Durieux ME, Marcus MA. 2003. Toxicity of local anaesthetics. Best Pract Res Clin Anaesthesiol. 17:111–136.
   PubMedGoogle Scholar
• Cox JA, Kucenas S, Voigt MM. 2005. Molecular characterization and embryonic expression of the family of N-methyl-D-aspartate receptor subunit genes in the zebrafish. Dev Dyn. 234:756–766.
   PubMed Web of Science ®Google Scholar
• Creeley C, Dikranian K, Dissen G, Martin L, Olney J, Brambrink A. 2013. Propofol-induced apoptosis of neurones and oligodendrocytes in fetal and neonatal rhesus macaque brain. Br J Anaesth. 110:i29–38.
   PubMed Web of Science ®Google Scholar
• Cuevas E, Trickler WJ, Guo X, Ali SF, Paule MG, Kanungo J. 2013. Acetyl L-carnitine protects motor neurons and Rohon-Beard sensory neurons against ketamine-induced neurotoxicity in zebrafish embryos. Neurotoxicol Teratol. 39:69–76.
   PubMed Web of Science ®Google Scholar
• Culley DJ, Avram MJ. 2018. Young brain and anesthesia: Refusal of anesthesia Is not an option! Anesthesiology. 128:697–699.
   PubMed Web of Science ®Google Scholar
• d'Amora M, Giordani S. 2018. The utility of zebrafish as a model for screening developmental neurotoxicity. Front Neurosci. 12:976.
   PubMed Web of Science ®Google Scholar
• David RM, Jones HS, Panter GH, Winter MJ, Hutchinson TH, Kevin Chipman J. 2012. Interference with xenobiotic metabolic activity by the commonly used vehicle solvents dimethylsulfoxide and methanol in zebrafish (Danio rerio) larvae but not Daphnia magna. Chemosphere. 88:912–917.
   PubMed Web of Science ®Google Scholar
• Davidson A. 2016. The effect of anaesthesia on the infant brain. Early Hum Dev. 102:37–40.
   PubMed Web of Science ®Google Scholar
• Demin KA, Meshalkina DA, Kysil EV, Antonova KA, Volgin AD, Yakovlev OA, Alekseeva PA, Firuleva MM, Lakstygal AM, de Abreu MS, et al. 2018. Zebrafish models relevant to studying central opioid and endocannabinoid systems. Prog Neuropsychopharmacol Biol Psych. 86:301–312.
   PubMed Web of Science ®Google Scholar
• Dobbing J, Sands J. 1979. Comparative aspects of the brain growth spurt. Early Hum Dev. 3:79–83.
   PubMed Web of Science ®Google Scholar
• Doke SK, Dhawale SC. 2015. Alternatives to animal testing: a review. Saudi Pharm J. 23:223–229.
   PubMed Web of Science ®Google Scholar
• Du WJ, Zhang RW, Li J, Zhang BB, Peng XL, Cao S, Yuan J, Yuan CD, Yu T, Du JL. 2018. The locus coeruleus modulates intravenous general anesthesia of zebrafish via a cooperative mechanism. Cell Rep. 24:3146–3155 e3.
   PubMed Web of Science ®Google Scholar
• EU. 2010. Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes. Off J Eur Union. 276:33–79.
   Google Scholar
• Felix LM, Antunes LM, Coimbra AM. 2014. Ketamine NMDA receptor-independent toxicity during zebrafish (Danio rerio) embryonic development. Neurotoxicol Teratol. 41:27–34.
   PubMed Web of Science ®Google Scholar
• Felix LM, Antunes LM, Coimbra AM, Valentim AM. 2017. Behavioral alterations of zebrafish larvae after early embryonic exposure to ketamine. Psychopharmacology (Berl). 234:549–558.
   PubMed Web of Science ®Google Scholar
• Felix LM, Luzio A, Themudo M, Antunes L, Matos M, Coimbra AM, Valentim AM. 2018. MS-222 short exposure induces developmental and behavioural alterations in zebrafish embryos. Reprod Toxicol. 81:122–131.
   PubMed Web of Science ®Google Scholar
• Felix LM, Serafim C, Martins MJ, Valentim AM, Antunes LM, Matos M, Coimbra AM. 2017. Morphological and behavioral responses of zebrafish after 24h of ketamine embryonic exposure. Toxicol Appl Pharmacol. 321:27–36.
   PubMed Web of Science ®Google Scholar
• Felix LM, Serafim C, Valentim AM, Antunes LM, Campos S, Matos M, Coimbra AM. 2016. Embryonic stage-dependent teratogenicity of ketamine in zebrafish (Danio rerio). Chem Res Toxicol. 29:1298–1309.
   PubMed Web of Science ®Google Scholar
• Felix LM, Serafim C, Valentim AM, Antunes LM, Matos M, Coimbra AM. 2017. Apoptosis-related genes induced in response to ketamine during early life stages of zebrafish. Toxicol Lett. 279:1–8.
   PubMed Web of Science ®Google Scholar
• Felix LM, Vidal AM, Serafim C, Valentim AM, Antunes LM, Campos S, Matos M, Monteiro SM, Coimbra AM. 2016. Ketamine-induced oxidative stress at different developmental stages of zebrafish (Danio rerio) embryos. Rsc Adv. 6:61254–61266.
   Web of Science ®Google Scholar
• Felix LM, Vidal AM, Serafim C, Valentim AM, Antunes LM, Monteiro SM, Matos M, Coimbra AM. 2018. Ketamine induction of p53-dependent apoptosis and oxidative stress in zebrafish (Danio rerio) embryos. Chemosphere. 201:730–739.
   PubMed Web of Science ®Google Scholar
• Ferreira AL, Nunes C, Mendes JG, Amorim P. 2019. Do we have today a reliable method to detect the moment of loss of consciousness during induction of general anaesthesia? Rev Esp Anestesiol Reanim. 66:93–103.
   PubMed Web of Science ®Google Scholar
• Festing S, Wilkinson R. 2007. The ethics of animal research. Talking point on the use of animals in scientific research. EMBO Rep. 8:526–530.
   PubMed Web of Science ®Google Scholar
• Fleming A, Alderton WK. 2013. Zebrafish in pharmaceutical industry research: finding the best fit. Drug Discov Today Dis Models. 10:e43–e50.
   Google Scholar
• Fujinaga M. 1998. Assessment of teratogenic effects of lidocaine in rat embryos cultured in vitro. Anesthesiology. 89:1553–1558.
   PubMed Web of Science ®Google Scholar
• Fujinaga M, Mazze RI. 1986. Reproductive and teratogenic effects of lidocaine in Sprague-Dawley rats. Anesthesiology. 65:626–632.
   PubMed Web of Science ®Google Scholar
• Fujinaga M, Mazze RI. 1988. Teratogenic and postnatal developmental studies of morphine in Sprague-Dawley rats. Teratology. 38:401–410.
   PubMedGoogle Scholar
• Fujinaga M, Mazze RI, Jackson EC, Baden JM. 1988. Reproductive and teratogenic effects of sufentanil and alfentanil in Sprague-Dawley rats. Anesth Anal. 67:166–169.
   Web of Science ®Google Scholar
• Fujinaga M, Stevenson JB, Mazze RI. 1986. Reproductive and teratogenic effects of fentanyl in Sprague-Dawley rats. Teratology. 34:51–57.
   PubMedGoogle Scholar
• Giacomotto J, Segalat L. 2010. High-throughput screening and small animal models, where are we? Br J Pharmacol. 160:204–216.
   PubMed Web of Science ®Google Scholar
• Gomez de la Torre Canny, S, Holterhoff, CK, Behringer, RR, Wagner, DS, Kozlowski, DJ. 2009. Go Fish! Developmental Stages in Zebrafish. Cover illustration and poster supplement for Genesis. J Genet Dev. 47. DOI:10.1002/dvg.20525
   Google Scholar
• Goetzl L. 2010. Adverse pregnancy outcomes after abnormal first-trimester screening for aneuploidy. Clin Lab Med. 30:613–628.
   PubMed Web of Science ®Google Scholar
• Gohlke JM, Hiller-Sturmhofel S, Faustman EM. 2008. A systems-based computational model of alcohol's toxic effects on brain development. Alcohol Res Health. 31:76–83.
   PubMedGoogle Scholar
• Griffin CE, 3rd, Kaye AM, Bueno FR, Kaye AD. 2013. Benzodiazepine pharmacology and central nervous system-mediated effects. Ochsner J. 13:214–223.
   PubMedGoogle Scholar
• Guo P, Huang Z, Tao T, Chen X, Zhang W, Zhang Y, Lin C. 2015. Zebrafish as a model for studying the developmental neurotoxicity of propofol. J Appl Toxicol. 35:1511–1519.
   PubMed Web of Science ®Google Scholar
• Herlenius E, Lagercrantz H. 2001. Neurotransmitters and neuromodulators during early human development. Early Hum Dev. 65:21–37.
   PubMed Web of Science ®Google Scholar
• Herrero-Turrion MJ, Rodriguez-Martin I, Lopez-Bellido R, Rodriguez RE. 2014. Whole-genome expression profile in zebrafish embryos after chronic exposure to morphine: identification of new genes associated with neuronal function and mu opioid receptor expression. BMC Genomics. 15:874.
   PubMed Web of Science ®Google Scholar
• Higashijima S, Mandel G, Fetcho JR. 2004. Distribution of prospective glutamatergic, glycinergic, and GABAergic neurons in embryonic and larval zebrafish. J Comp Neurol. 480:1–18.
   PubMed Web of Science ®Google Scholar
• Horzmann KA, Freeman JL. 2016. Zebrafish get connected: investigating neurotransmission targets and alterations in chemical toxicity. Toxics. 4:19.
   PubMed Web of Science ®Google Scholar
• Huang SH, Huang KS, Yu CH, Gong HY. 2013. Metabolic profile analysis of a single developing zebrafish embryo via monitoring of oxygen consumption rates within a microfluidic device. Biomicrofluidics. 7:64107.
   PubMed Web of Science ®Google Scholar
• Hudson AE, Hemmings HC. Jr. 2011. Are anaesthetics toxic to the brain? Br J Anaesth. 107:30–37.
   PubMed Web of Science ®Google Scholar
• Istaphanous GK, Howard J, Nan X, Hughes EA, McCann JC, McAuliffe JJ, Danzer SC, Loepke AW. 2011. Comparison of the neuroapoptotic properties of equipotent anesthetic concentrations of desflurane, isoflurane, or sevoflurane in neonatal mice. Anesthesiology. 114:578–587.
   PubMed Web of Science ®Google Scholar
• Jeong JY, Kwon HB, Ahn JC, Kang D, Kwon SH, Park JA, Kim KW. 2008. Functional and developmental analysis of the blood-brain barrier in zebrafish. Brain Res Bull. 75:619–628.
   PubMed Web of Science ®Google Scholar
• Jimenez-Gonzalez A, Garcia-Concejo A, Leon-Lobera F, Rodriguez RE. 2018. Morphine delays neural stem cells differentiation by facilitating Nestin overexpression. Biochim Biophys Acta Gen Subj. 1862:474–484.
   PubMed Web of Science ®Google Scholar
• Kalueff AV, Stewart AM, Gerlai R. 2014. Zebrafish as an emerging model for studying complex brain disorders. Trends Pharmacol Sci. 35:63–75.
   PubMed Web of Science ®Google Scholar
• Kang E, Berg DA, Furmanski O, Jackson WM, Ryu YK, Gray CD, Mintz CD. 2017. Neurogenesis and developmental anesthetic neurotoxicity. Neurotoxicol Teratol. 60:33–39.
   PubMed Web of Science ®Google Scholar
• Kanungo J, Cuevas E, Ali SF, Paule MG. 2012. L-Carnitine rescues ketamine-induced attenuated heart rate and MAPK (ERK) activity in zebrafish embryos. Reprod Toxicol. 33:205–212.
   PubMed Web of Science ®Google Scholar
• Kanungo J, Cuevas E, Ali SF, Paule MG. 2013. Ketamine induces motor neuron toxicity and alters neurogenic and proneural gene expression in zebrafish. J Appl Toxicol. 33:410–417.
   PubMed Web of Science ®Google Scholar
• Kanungo J, Cuevas E, Ali SF, Paule MG. 2014. Zebrafish model in drug safety assessment. Curr Pharm Des. 20:5416–5429.
   PubMed Web of Science ®Google Scholar
• Key KL, Rich C, DeCristofaro C, Collins S. 2010. Use of propofol and emergence agitation in children: a literature review. Aana J. 78:468–473.
   PubMedGoogle Scholar
• Kimmel CB, Ballard WW, Kimmel SR, Ullmann B, Schilling TF. 1995. Stages of embryonic development of the zebrafish. Dev Dyn. 203:253–310.
   PubMed Web of Science ®Google Scholar
• Ku T-H, Ken C-F, Yang S-F, Tsao Y-M, Chen G, Tang C-Y. 2013. Isoflurane anesthesia EC50 and LC50 for zebrafish: 9AP5‐8. Eur J Anaesthesiol. 30:153–154.
   Google Scholar
• Veeck LL, Zaninovic N. 2003. An atlas of human blastocysts. New York: Parthenon Publishing Group.
   Google Scholar
• Lei X, Guo Q, Zhang J. 2012. Mechanistic insights into neurotoxicity induced by anesthetics in the developing brain. Int J Mol Sci. 13:6772–6799.
   PubMed Web of Science ®Google Scholar
• Lewis KE, Eisen JS. 2003. From cells to circuits: development of the zebrafish spinal cord. Prog Neurobiol. 69:419–449.
   PubMed Web of Science ®Google Scholar
• Liu C, Lin C, Guo P, Zhang X, Zhu X. 2018. Exposure to propofol down-regulates myelin basic protein expression in zebrafish embryos: its neurotoxicity on oligodendrocytes and the molecular mechanisms. Nan Fang Yi Ke Da Xue Xue Bao 38:1115–1120.
   PubMedGoogle Scholar
• Ljujic M, Varga M, Bartel S, Krauss-Etschmann S, Divac Rankov A. 2018. Zebrafish as a model for study of developmental origins of chronic lung diseases. Eur Respir J. 52:PA1389.
   Web of Science ®Google Scholar
• Lomba L, Ribate MP, Zuriaga E, Garcia CB, Giner B. 2019. Acute and subacute effects of drugs in embryos of Danio rerio. QSAR grouping and modelling. Ecotoxicol Environ Saf. 172:232–239.
   PubMed Web of Science ®Google Scholar
• Lopez-Luna J, Al-Jubouri Q, Al-Nuaimy W, Sneddon LU. 2017. Reduction in activity by noxious chemical stimulation is ameliorated by immersion in analgesic drugs in zebrafish. J Exp Biol. 220:1451–1458.
   PubMed Web of Science ®Google Scholar
• Malinovsky JM, Lejus C, Servin F, Lepage JY, Le Normand Y, Testa S, Cozian A, Pinaud M. 1993. Plasma concentrations of midazolam after i.v., nasal or rectal administration in children. Br J Anaesth. 70:617–620.
   PubMed Web of Science ®Google Scholar
• Mandt MJ, Roback MG, Bajaj L, Galinkin JL, Gao D, Wathen JE. 2012. Etomidate for short pediatric procedures in the emergency department. Pediatr Emerg Care. 28:898–904.
   PubMed Web of Science ®Google Scholar
• Martins T, Diniz E, Felix LM, Antunes L. 2018. Evaluation of anaesthetic protocols for laboratory adult zebrafish (Danio rerio). PLoS One. 13:e0197846.
   PubMed Web of Science ®Google Scholar
• Mottaz H, Schonenberger R, Fischer S, Eggen RIL, Schirmer K, Groh KJ. 2017. Dose-dependent effects of morphine on lipopolysaccharide (LPS)-induced inflammation, and involvement of multixenobiotic resistance (MXR) transporters in LPS efflux in teleost fish. Environ Pollut. 221:105–115.
   PubMed Web of Science ®Google Scholar
• Neiffer DL, Stamper MA. 2009. Fish sedation, analgesia, anesthesia, and euthanasia: considerations, methods, and types of drugs. Ilar J. 50:343–360.
   PubMed Web of Science ®Google Scholar
• Neuman G, Koren G. 2013. Motherisk rounds: safety of procedural sedation in pregnancy. J Obstet Gynaecol Can. 35:168–173.
   PubMedGoogle Scholar
• Nishimura Y, Inoue A, Sasagawa S, Koiwa J, Kawaguchi K, Kawase R, Maruyama T, Kim S, Tanaka T. 2016. Using zebrafish in systems toxicology for developmental toxicity testing. Congenit Anom. 56:18–27.
   PubMed Web of Science ®Google Scholar
• Nishimura Y, Murakami S, Ashikawa Y, Sasagawa S, Umemoto N, Shimada Y, Tanaka T. 2015. Zebrafish as a systems toxicology model for developmental neurotoxicity testing. Congenit Anom (Kyoto). 55:1–16.
   PubMed Web of Science ®Google Scholar
• Nyman Y, Fredriksson A, Lonnqvist PA, Viberg H. 2016. Etomidate exposure in early infant mice (P10) does not induce apoptosis or affect behaviour. Acta Anaesthesiol Scand. 60:588–596.
   PubMed Web of Science ®Google Scholar
• O'Shea KS, Kaufman MH. 1980. Neural tube closure defects following in vitro exposure of mouse embryos to xylocaine. J Exp Zool. 214:235–238.
   PubMedGoogle Scholar
• Oggier DM, Weisbrod CJ, Stoller AM, Zenker AK, Fent K. 2010. Effects of diazepam on gene expression and link to physiological effects in different life stages in zebrafish Danio rerio. Environ Sci Technol. 44:7685–7691.
   PubMed Web of Science ®Google Scholar
• Olsen EA, Brambrink AM. 2013. Anesthetic neurotoxicity in the newborn and infant. Curr Opin Anaesthesiol. 26:535–542.
   PubMed Web of Science ®Google Scholar
• Oosterhof N, Boddeke E, van Ham TJ. 2015. Immune cell dynamics in the CNS: learning from the zebrafish. Glia 63:719–735.
   PubMed Web of Science ®Google Scholar
• Ostrer H, Wilson DI, Hanley NA. 2006. Human embryo and early fetus research. Clin Genet. 70:98–107.
   PubMed Web of Science ®Google Scholar
• Panula P, Chen YC, Priyadarshini M, Kudo H, Semenova S, Sundvik M, Sallinen V. 2010. The comparative neuroanatomy and neurochemistry of zebrafish CNS systems of relevance to human neuropsychiatric diseases. Neurobiol Dis. 40:46–57.
   PubMed Web of Science ®Google Scholar
• Perna RB, Loughan AR, Le JA, Hertza J. 2015. Prenatal and perinatal anesthesia and the long-term cognitive sequelae: a review. Appl Neuropsychol Child. 4:65–71.
   PubMed Web of Science ®Google Scholar
• Postlethwait J, Amores A, Cresko W, Singer A, Yan YL. 2004. Subfunction partitioning, the teleost radiation and the annotation of the human genome. Trends Genet. 20:481–490.
   PubMed Web of Science ®Google Scholar
• Przewlocki R. 2004. Opioid abuse and brain gene expression. Eur J Pharmacol. 500:331–349.
   PubMed Web of Science ®Google Scholar
• Ramazzotto LJ, Curro FA, Paterson JA, Tanner P, Coleman M. 1985. Toxicological assessment of lidocaine in the pregnant rat. J Dent Res. 64:1214–1217.
   PubMed Web of Science ®Google Scholar
• Rand-Weaver M, Margiotta-Casaluci L, Patel A, Panter GH, Owen SF, Sumpter JP. 2013. The read-across hypothesis and environmental risk assessment of pharmaceuticals. Environ Sci Technol. 47:11384–11395.
   PubMed Web of Science ®Google Scholar
• Redmond C. 2014. 'One R' is the new 'Three Rs'. ATLA. 42:P50–2.
   Google Scholar
• Reitman E, Flood P. 2011. Anaesthetic considerations for non-obstetric surgery during pregnancy. Br J Anaesth. 107:i72–8.
   PubMed Web of Science ®Google Scholar
• Renshaw SA, Loynes CA, Elworthy S, Ingham PW, Whyte MK. 2007. Modeling inflammation in the zebrafish: how a fish can help us understand lung disease. Exp Lung Res. 33:549–554.
   PubMed Web of Science ®Google Scholar
• Rico EP, Rosemberg DB, Seibt KJ, Capiotti KM, Da Silva RS, Bonan CD. 2011. Zebrafish neurotransmitter systems as potential pharmacological and toxicological targets. Neurotoxicol Teratol. 33:608–617.
   PubMed Web of Science ®Google Scholar
• Ritter LM, Unis AS, Meador-Woodruff JH. 2001. Ontogeny of ionotropic glutamate receptor expression in human fetal brain. Brain Res Dev Brain Res. 127:123–133.
   PubMedGoogle Scholar
• Robinson BL, Dumas M, Ali SF, Paule MG, Gu Q, Kanungo J. 2018. Mechanistic studies on ketamine-induced mitochondrial toxicity in zebrafish embryos. Neurotoxicol Teratol. 69:63–72.
   PubMed Web of Science ®Google Scholar
• Robinson BL, Dumas M, Cuevas E, Gu Q, Paule MG, Ali SF, Kanungo J. 2016. Distinct effects of ketamine and acetyl L-carnitine on the dopamine system in zebrafish. Neurotoxicol Teratol. 54:52–60.
   PubMed Web of Science ®Google Scholar
• Robinson B, Dumas M, Gu Q, Kanungo J. 2018. N-acetylcysteine prevents ketamine-induced adverse effects on development, heart rate and monoaminergic neurons in zebrafish. Neurosci Lett. 682:56–61.
   PubMed Web of Science ®Google Scholar
• Robinson BL, Dumas M, Paule MG, Ali SF, Kanungo J. 2015. Opposing effects of ketamine and acetyl L-carnitine on the serotonergic system of zebrafish. Neurosci Lett. 607:17–22.
   PubMed Web of Science ®Google Scholar
• Robinson BL, Dumas M, Ali SF, Paule MG, Gu Q, Kanungo J. 2017. Cyclosporine exacerbates ketamine toxicity in zebrafish: mechanistic studies on drug-drug interaction. J Appl Toxicol. 37(12):1438–1447.
   PubMed Web of Science ®Google Scholar
• Rodriguez F, Lopez JC, Vargas JP, Broglio C, Gomez Y, Salas C. 2002. Spatial memory and hippocampal pallium through vertebrate evolution: insights from reptiles and teleost fish. Brain Res Bull. 57:499–503.
   PubMed Web of Science ®Google Scholar
• Saint-Amant L. 2006. Development of motor networks in zebrafish embryos. Zebrafish. 3:173–190.
   PubMed Web of Science ®Google Scholar
• Saint-Amant L, Drapeau P. 1998. Time course of the development of motor behaviors in the zebrafish embryo. J Neurobiol. 37:622–632.
   PubMedGoogle Scholar
• Saint-Raymond A, de Vries CS. 2016. Medicine safety in pregnancy and ambitions for the EU medicine regulatory framework. Clin Pharmacol Ther. 100:21–23.
   PubMed Web of Science ®Google Scholar
• Sanchez-Simon FM, Arenzana FJ, Rodriguez RE. 2010. In vivo effects of morphine on neuronal fate and opioid receptor expression in zebrafish embryos. Eur J Neurosci. 32:550–559.
   PubMed Web of Science ®Google Scholar
• Sanchez-Simon FM, Zhang XX, Loh HH, Law PY, Rodriguez RE. 2010. Morphine regulates dopaminergic neuron differentiation via miR-133b. Mol Pharmacol. 78:935–942.
   PubMed Web of Science ®Google Scholar
• Sanders RD, Hassell J, Davidson AJ, Robertson NJ, Ma D. 2013. Impact of anaesthetics and surgery on neurodevelopment: an update. Br J Anaesth. 110 (Suppl 1):i53–72.
   PubMed Web of Science ®Google Scholar
• Schechtman LM. 2002. Implementation of the 3Rs (refinement, reduction, and replacement): validation and regulatory acceptance considerations for alternative toxicological test methods. ILAR J. 43:S85–S94.
   PubMedGoogle Scholar
• Schmidt R, Strahle U, Scholpp S. 2013. Neurogenesis in zebrafish – from embryo to adult. Neural Dev. 8:3–3.
   PubMed Web of Science ®Google Scholar
• Schneider H. 2017. Zebrafish neurobehavioral assays for drug addiction research. In: Kalueff AV, editor. The rights and wrongs of zebrafish: behavioral phenotyping of zebrafish. Cham: Springer International Publishing; p. 171–205.
   Google Scholar
• Schubert S, Keddig N, Hanel R, Kammann U. 2014. Microinjection into zebrafish embryos (Danio rerio) – a useful tool in aquatic toxicity testing? Env Sci Eur. 26:1–8.
   Google Scholar
• Schumann J. 2010. Teratogen screening: state of the art. Avicenna J Med Biotechnol. 2:115–121.
   PubMedGoogle Scholar
• Semple BD, Blomgren K, Gimlin K, Ferriero DM, Noble-Haeusslein LJ. 2013. Brain development in rodents and humans: identifying benchmarks of maturation and vulnerability to injury across species. Prog Neurobiol. 106–107:1–16.
   PubMed Web of Science ®Google Scholar
• Sleigh J, Harvey M, Voss L, Denny B. 2014. Ketamine – more mechanisms of action than just NMDA blockade. Trends Anaesth Critic Care. 4:76–81.
   Google Scholar
• Smith RF, Kurkjian MF, Mattran KM, Kurtz SL. 1989. Behavioral effects of prenatal exposure to lidocaine in the rat: effects of dosage and of gestational age at administration. Neurotoxicol Teratol. 11:395–403.
   PubMed Web of Science ®Google Scholar
• Sneddon LU. 2012. Clinical anesthesia and analgesia in fish. J Exot Pet Med. 21:32–43.
   Web of Science ®Google Scholar
• Soares J, Coimbra AM, Reis-Henriques MA, Monteiro NM, Vieira MN, Oliveira JM, Guedes-Dias P, Fontainhas-Fernandes A, Parra SS, Carvalho AP, et al. 2009. Disruption of zebrafish (Danio rerio) embryonic development after full life-cycle parental exposure to low levels of ethinylestradiol. Aquat Toxicol. 95:330–338.
   PubMed Web of Science ®Google Scholar
• Spence R, Gerlach G, Lawrence C, Smith C. 2008. The behaviour and ecology of the zebrafish, Danio rerio. Biol Rev Camb Philos Soc. 83:13–34.
   PubMed Web of Science ®Google Scholar
• Stackley KD, Beeson CC, Rahn JJ, Chan SS. 2011. Bioenergetic profiling of zebrafish embryonic development. PLoS One. 6:e25652.
   PubMed Web of Science ®Google Scholar
• Stewart A, Wong K, Cachat J, Gaikwad S, Kyzar E, Wu N, Hart P, Piet V, Utterback E, Elegante M, et al. 2011. Zebrafish models to study drug abuse-related phenotypes. Rev Neurosci. 22:95–105.
   PubMed Web of Science ®Google Scholar
• Strahle U, Scholz S, Geisler R, Greiner P, Hollert H, Rastegar S, Schumacher A, Selderslaghs I, Weiss C, Witters H, Braunbeck T. 2012. Zebrafish embryos as an alternative to animal experiments-a commentary on the definition of the onset of protected life stages in animal welfare regulations. Reprod Toxicol. 33:128–132.
   PubMed Web of Science ®Google Scholar
• Su F, El-Komy MH, Hammer GB, Frymoyer A, Cohane CA, Drover DR. 2015. Population pharmacokinetics of etomidate in neonates and infants with congenital heart disease. Biopharm Drug Dispos. 36:104–114.
   PubMed Web of Science ®Google Scholar
• Sun L. 2010. Early childhood general anaesthesia exposure and neurocognitive development. Br J Anaesth. 105:i61–8.
   PubMed Web of Science ®Google Scholar
• Taylor KL, Grant NJ, Temperley ND, Patton EE. 2010. Small molecule screening in zebrafish: an in vivo approach to identifying new chemical tools and drug leads. Cell Commun Signal. 8:11.
   PubMed Web of Science ®Google Scholar
• Teiling AK, Mohammed AK, Minor BG, Jarbe TU, Hiltunen AJ, Archer T. 1987. Lack of effects of prenatal exposure to lidocaine on development of behavior in rats. Anesth Analg. 66:533–541.
   PubMed Web of Science ®Google Scholar
• Tobias JD. 2015. Etomidate in pediatric anesthesiology: Where are we now? Saudi J Anaesth. 9:451–456.
   PubMed Web of Science ®Google Scholar
• Trickler WJ, Guo X, Cuevas E, Ali SF, Paule MG, Kanungo J. 2014. Ketamine attenuates cytochrome p450 aromatase gene expression and estradiol-17beta levels in zebrafish early life stages. J Appl Toxicol. 34:480–488.
   PubMed Web of Science ®Google Scholar
• Tropepe V, Sive HL. 2003. Can zebrafish be used as a model to study the neurodevelopmental causes of autism? Genes Brain Behav. 2:268–281.
   PubMed Web of Science ®Google Scholar
• Truong L, Harper SL, Tanguay RL. 2011. Evaluation of embryotoxicity using the zebrafish model. Methods Mol Biol. 691:271–279.
   PubMedGoogle Scholar
• Upadya M, Saneesh PJ. 2016. Anaesthesia for non-obstetric surgery during pregnancy. Indian J Anaesth. 60:234–241.
   PubMed Web of Science ®Google Scholar
• Veldman MB, Lin S. 2008. Zebrafish as a developmental model organism for pediatric research. Pediatr Res. 64:470–476.
   PubMed Web of Science ®Google Scholar
• Verbueken E, Alsop D, Saad MA, Pype C, Van Peer EM, Casteleyn CR, Van Ginneken CJ, Wilson J, Van Cruchten SJ. 2017. In vitro biotransformation of two human cyp3a probe substrates and their inhibition during early zebrafish development. IJMS 18:217.
   Google Scholar
• Vilela SM, Santos DJ, Felix L, Almeida JM, Antunes L, Peixoto F. 2009. Are fentanyl and remifentanil safe opioids for rat brain mitochondrial bioenergetics? Mitochondrion 9:247–253.
   PubMed Web of Science ®Google Scholar
• Vliegenthart AD, Tucker CS, Del Pozo J, Dear JW. 2014. Zebrafish as model organisms for studying drug-induced liver injury. Br J Clin Pharmacol. 78:1217–1227.
   PubMed Web of Science ®Google Scholar
• Vutskits L, Davidson A. 2017. Update on developmental anesthesia neurotoxicity. Curr Opin Anaesthesiol. 30:337–342.
   PubMed Web of Science ®Google Scholar
• Walton NKD, Melachuri VK. 2006. Anaesthesia for non-obstetric surgery during pregnancy. Continuing education in anaesthesia. Critical Care Pain. 6:83–85.
   Google Scholar
• Westerfield M. 2000. The zebrafish book. A guide for the laboratory use of zebrafish (Danio rerio). Eugene, OR: University of Oregon Press.
   Google Scholar
• Wolman MA, Jain RA, Liss L, Granato M. 2011. Chemical modulation of memory formation in larval zebrafish. Proc Natl Acad Sci USA. 108:15468–15473.
   PubMed Web of Science ®Google Scholar
• Woods IG, Kelly PD, Chu F, Ngo-Hazelett P, Yan YL, Huang H, Postlethwait JH, Talbot WS. 2000. A comparative map of the zebrafish genome. Genome Res. 10:1903–1914.
   PubMed Web of Science ®Google Scholar
• Yazdy MM, Desai RJ, Brogly SB. 2015. Prescription opioids in pregnancy and birth outcomes: a review of the literature. J Pediatr Genet. 4:56–70.
   PubMed Web of Science ®Google Scholar
• Yu D, Jiang Y, Gao J, Liu B, Chen P. 2013. Repeated exposure to propofol potentiates neuroapoptosis and long-term behavioral deficits in neonatal rats. Neurosci Lett. 534:41–46.
   PubMed Web of Science ®Google Scholar
• Zahid H, Tsang B, Ahmed H, Lee RCY, Tran S, Gerlai R. 2018. Diazepam fails to alter anxiety-like responses but affects motor function in a white-black test paradigm in larval zebrafish (Danio rerio). Prog Neuropsychopharmacol Biol Psychiatry 83:127–136.
   PubMed Web of Science ®Google Scholar
• Zhou P, Jiang J, Yan H, Li Y, Zhao J, Wang X, Su R, Gong Z. 2018. ABIN-1 negatively regulates μ-opioid receptor function. Mol Pharmacol. 93:36–48.
   PubMed Web of Science ®Google Scholar
• Zhou Z, Ma D. 2014. Anaesthetics-induced neurotoxicity in developing brain: an update on preclinical evidence. Brain Sci. 4:136–149.
   PubMedGoogle Scholar