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Review Articles

Cadmium exposure and DNA damage (genotoxicity): a systematic review and meta-analysis

ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 786-798 | Received 30 Dec 2022, Accepted 18 Jan 2023, Published online: 21 Feb 2023

References

  • Abrahim KS, Abdel-Gawad NB, Mahmoud AM, El-Gowaily MM, Emara AM, Hwaihy MM. 2011. Genotoxic effect of occupational exposure to cadmium. Toxicol Ind Health. 27(2):173–179.
  • Aksu İ, Anlar HG, Taner G, Bacanlı M, İritaş S, Tutkun E, Basaran N. 2019. Assessment of DNA damage in welders using comet and micronucleus assays. Mutat Res Genet Toxicol Environ Mutagen. 843:40–45.
  • Alabi OA, Adeoluwa YM, Bakare AA. 2020. Elevated serum Pb, Ni, Cd, and Cr levels and DNA damage in exfoliated buccal cells of teenage scavengers at a major electronic waste dumpsite in Lagos, Nigeria. Biol Trace Elem Res. 194(1):24–33.
  • Altman D, Machin D, Bryant T, Gardner M. 2000. Statistics with confidence 2nd ed – D. Altman, et al (BMJ, 2005) WW.pdf. VI Int Conf Phot Correl Other Tech Fluid Mech.
  • Bagepally BS, Balachandar R, Kalahasthi R, Tripathi R, Haridoss M. 2021. Association between aluminium exposure and cognitive functions: a systematic review and meta-analysis. Chemosphere. 268:128831.
  • Bauchinger M, Schmid E, Einbrodt HJ, Dresp J. 1976. Chromosome aberrations in lymphocytes after occupational exposure to lead and cadmium. Mutat Res Toxicol. 40(1):57–61.
  • Bertin G, Averbeck D. 2006. Cadmium: cellular effects, modifications of biomolecules, modulation of DNA repair and genotoxic consequences (a review). Biochimie. 88(11):1549–1559.
  • Botta C, Iarmarcovai G, Chaspoul F, Sari-Minodier I, Pompili J, Orsière T, Bergé-Lefranc JL, Botta A, Gallice P, De Méo M. 2006. Assessment of occupational exposure to welding fumes by inductively coupled plasma-mass spectroscopy and by the alkaline comet assay. Environ Mol Mutagen. 47(4):284–295.
  • Carvalho RB, Carneiro MFH, Barbosa F, Batista BL, Simonetti J, Amantéa SL, Rhoden CR. 2018. The impact of occupational exposure to traffic-related air pollution among professional motorcyclists from Porto Alegre, Brazil, and its association with genetic and oxidative damage. Environ Sci Pollut Res Int. 25(19):18620–18631.
  • Cassini C, Calloni C, Bortolini G, Garcia SC, Dornelles MA, Henriques JAP, Erdtmann B, Salvador M. 2011. Occupational risk assessment of oxidative stress and genotoxicity in workers exposed to paints during a working week. Int J Occup Med Environ Health. 24(3):308–319.
  • Cordelli E, Bignami M, Pacchierotti F. 2021. Comet assay: a versatile but complex tool in genotoxicity testing. Toxicol Res. 10(1):68–78.
  • Costa S, Costa C, Madureira J, Valdiglesias V, Teixeira-Gomes A, Guedes de Pinho P, Laffon B, Teixeira JP. 2019. Occupational exposure to formaldehyde and early biomarkers of cancer risk, immunotoxicity and susceptibility. Environ Res. 179(Pt A):108740.
  • Cui ZG, Ahmed K, Zaidi SF, Muhammad JS. 2021. Ins and outs of cadmium-induced carcinogenesis: mechanism and prevention. Cancer Treat Res Commun. 27:100372.
  • de Angelis C, Galdiero M, Pivonello C, Salzano C, Gianfrilli D, Piscitelli P, Lenzi A, Colao A, Pivonello R. 2017. The environment and male reproduction: the effect of cadmium exposure on reproductive functions and its implication in fertility. Reprod Toxicol. 73:105–127.
  • DerSimonian R, Laird N. 2015. Meta-analysis in clinical trials revisited. Contemp Clin Trials. 45(Pt A):139–145.
  • Fatima G, Raza AM, Hadi N, Nigam N, Mahdi AA. 2019. Cadmium in human diseases: it’s more than just a mere metal. Indian J Clin Biochem. 34(4):371–378.
  • Fenech M, Bonassi S. 2011. The effect of age, gender, diet and lifestyle on DNA damage measured using micronucleus frequency in human peripheral blood lymphocytes. Mutagenesis. 26(1):43–49.
  • Filipič M. 2012. Mutation research/fundamental and molecular mechanisms of mutagenesis mechanisms of cadmium induced genomic instability. Mutat Res Mol Mech Mutagen. 733:71–79.
  • Filippini T, Torres D, Lopes C, Carvalho C, Moreira P, Naska A, Kasdagli MI, Malavolti M, Orsini N, Vinceti M. 2020. Cadmium exposure and risk of breast cancer: a dose-response meta-analysis of cohort studies. Environ Int. 142:105879.
  • Gashi G, Mahovlić V, Manxhuka–Kerliu S, Podrimaj-Bytyqi A, Gashi L, Elezaj IR. 2018. The association between micronucleus, nucleoplasmic bridges, and nuclear buds frequency and the degree of uterine cervical lesions. Biomarkers. 23(4):364–372.
  • Genchi G, Sinicropi MS, Lauria G, Carocci A, Catalano A. 2020. The effects of cadmium toxicity. Int J Environ Res Public Health. 17(11):3782.
  • Glei M, Schneider T, Schlörmann W. 2016. Comet assay: an essential tool in toxicological research. Arch Toxicol. 90(10):2315–2336.
  • Hambach R, Lison D, D'Haese P, Weyler J, François G, De Schryver A, Manuel-Y-Keenoy B, Van Soom U, Caeyers T, van Sprundel M. 2013. Adverse effects of low occupational cadmium exposure on renal and oxidative stress biomarkers in solderers. Occup Environ Med. 70(2):108–113.
  • Hamurcu Z, Donmez H, Saraymen R, Demirtas H. 2001. Micronucleus frequencies in workers exposed to lead, zinc, and cadmium. Biol Trace Elem Res. 83(2):97–102.
  • Hasani IW, El-Desouky MA, Sharaf NE, Abdel Shakour AA, Fahim YA, Ibrahim KA, Elhamshary M. 2016. Lead and cadmium induce chromosomal aberrations and DNA damage among foundry workers. J Chem Pharm Res. 8(2):652–661.
  • Hayashino Y, Noguchi Y, Fukui T. 2005. Systemic evaluation and comparison of statistical tests for publication bias. J Epidemiol. 15(6):235–243.
  • Hilgert Jacobsen-Pereira C, dos Santos CR, Troina Maraslis F, Pimentel L, Feijó AJL, Iomara Silva C, de Medeiros G, da S, Costa Zeferino R, Curi Pedrosa R, et al. 2018. Markers of genotoxicity and oxidative stress in farmers exposed to pesticides. Ecotoxicol Environ Saf. 148:177–183.
  • Hozo SP, Djulbegovic B, Hozo I. 2005. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol. 5(1):10–13.
  • Hartwig A, Asmuss A, Ehleben I, Herzer U, Kostelac D, Pelzer A, Schwerdtle T, Bürkle A. 2002. Interference of toxic metal ions with DNA repair processes and cell cycle control: molecular mechanisms. Environ Health Perspect. 110(5):797–799.
  • Huang HB, Chen GW, Wang CJ, Lin YY, Liou SH, Lai CH, Wang SL. 2013. Exposure to heavy metals and polycyclic aromatic hydrocarbons and DNA damage in Taiwanese traffic conductors. Cancer Epidemiol Biomarkers Prev. 22(1):102–108.
  • Iarmarcovai G, Sari-Minodier I, Chaspoul F, Botta C, De Méo M, Orsière T, Bergé-Lefranc JL, Gallice P, Botta A. 2005. Risk assessment of welders using analysis of eight metals by ICP-MS in blood and urine and DNA damage evaluation by the comet and micronucleus assays; influence of XRCC1 and XRCC3 polymorphisms. Mutagenesis. 20(6):425–432.
  • Ibrahem S, Hassan M, Ibraheem Q, Arif K. 2020. Genotoxic effect of lead and cadmium on workers at wastewater plant in Iraq. J Environ Public Health. 2020:9171027.
  • Ionescu ME, Ciocirlan M, Becheanu G, Nicolaie T, Ditescu C, Teiusanu AG, Gologan SI, Arbanas T, Diculescu MM. 2011. Nuclear division index may predict neoplastic colorectal lesions. Maedica. 6(3):173.
  • Järup L, Alfvén T. 2004. Low level cadmium exposure, renal and bone effects – the OSCAR study. Biometals. 17(5):505–509.
  • Kalahasthi R, Nagaraju R, Balachandar R, Bagepally BS. 2022. Association between occupational lead exposure and immunotoxicity markers: a systematic review and meta-analysis. Toxicology. 465:153047.
  • Kašuba V, Rozgaj R, Milić M, Želježić D, Kopjar N, Pizent A, Kljaković-Gašpić Z. 2010. Evaluation of lead exposure in battery-manufacturing workers with focus on different biomarkers. J Appl Toxicol. 30(4):321–328.
  • Kašuba V, Rozgaj R, Milić M, Želježić D, Kopjar N, Pizent A, Kljaković-Gašpić Z, Jazbec A. 2012. Evaluation of genotoxic effects of lead in pottery-glaze workers using micronucleus assay, alkaline comet assay and DNA diffusion assay. Int Arch Occup Environ Health. 85(7):807–818.
  • Khisroon M, Khan A, Shah AA, Ullah I, Farooqi J, Ullah A. 2021. Scalp hair metal analysis concerning DNA damage in welders of Peshawar Khyber Pakhtunkhwa Pakistan. Biol Trace Elem Res. 199(5):1649–1656.
  • Kumaravel TS, Vilhar B, Faux SP, Jha AN. 2009. Comet assay measurements: a perspective. Cell Biol Toxicol. 25(1):53–64.
  • Li P, Gu Y, Yu S, Li Y, Yang J, Jia G. 2014. Assessing the suitability of 8-OHdG and micronuclei as genotoxic biomarkers in chromate-exposed workers: a cross-sectional study. BMJ Open. 4(10):e005979.
  • Lin HC, Hao WM, Chu PH. 2021. Cadmium and cardiovascular disease: an overview of pathophysiology, epidemiology, therapy, and predictive value. Rev Port Cardiol. 40(8):611–617.
  • Lin TS, Wu CC, De WJ, Wei CH. 2012. Oxidative DNA damage estimated by urinary 8-hydroxy-2′-deoxyguanosine and arsenic in glass production workers. Toxicol Ind Health. 28(6):513–521.
  • Liu HH, Lin MH, Liu PC, Chan CI, Chen HL. 2009. Health risk assessment by measuring plasma malondialdehyde (MDA), urinary 8-hydroxydeoxyguanosine (8-OH-dG) and DNA strand breakage following metal exposure in foundry workers. J Hazard Mater. 170(2–3):699–704.
  • Luevano J, Damodaran C. 2014. A review of molecular events of cadmium-induced carcinogenesis. J Environ Pathol Toxicol Oncol. 33(3):183–194.
  • Lyu T, Zhou H, Wang Y, Jiang M, Tao Q, Chen J, Guo Y, Zhang Q, Wang X, Guo X. 2022. High-dose metformin induces a low-glucose dependent genotoxic stress. Food Chem Toxicol. 165:113129.
  • Maksoud NA, Aal KA, Ghandour N, El-Baz M, Shaltout E. 2018. Assessment of hematotoxicity and genotoxicity among paint workers in Assiut Governorate: a case control study. Egypt J Forensic Sci. 8(1):1–11.
  • Meyer AV, Tolochko TA, Minina VI, Timofeeva AA, Larionov AV. 2020. Complex approach to evaluating genotoxicity from occupational factors in coal mining industry. Russ J Genet. 56(5):611–617.
  • Mezynska M, Brzóska MM. 2018. Environmental exposure to cadmium—a risk for health of the general population in industrialized countries and preventive strategies. Environ Sci Pollut Res Int. 25(4):3211–3232.
  • Moitra S, Chakraborty K, Bhattacharyya A, Sahu S. 2015. Impact of occupational cadmium exposure on spirometry, sputum leukocyte count, and lung cell DNA damage among Indian goldsmiths. Am J Ind Med. 58(6):617–624.
  • Nagaraju R, Kalahasthi R, Balachandar R, Bagepally BS. 2022. Association between lead exposure and DNA damage (genotoxicity): systematic review and meta-analysis. Arch Toxicol. 96(11):2899–2911.
  • Nsonwu-Anyanwu. 2021. Chronic exposure to toluene and heavy metals and changes in indices of liver function, inflammation and oxidative DNA damage among automobile workers. Asia Pac J Med Toxicol. 10(2):53–60.
  • Obaji-Ogar LT, Nsonwu-Anyanwu AC, Odum FA. 2020. Oxidative DNA damage and pro-inflammatory response in chronic exposure to cement dust. Arch Bone Jt Surg. 9(1):3–10.
  • OSHA. 2004. Cadmium, occupation safety and health administration; p. 1–27. https://www.osha.gov/sites/default/files/pub.
  • Ostoich PV, Beltcheva M, Metcheva R. 2020. Nefarious, but in a different way: comparing the ecotoxicity, gene toxicity and mutagenicity of lead (Pb) and cadmium (Cd) in the context of small mammal ecotoxicology. In: Genotoxicity and mutagenicity-mechanisms and test methods. London (UK): IntechOpen.
  • Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. 2016. Rayyan-a web and mobile app for systematic reviews. Syst Rev. 5(1):1–10.
  • Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE. 2021. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 372(1):11.
  • Park E, Kim S, Song SH, Lee CW, Kwon JT, Lim MK, Park EY, Won YJ, Jung KW, Kim B. 2021. Environmental exposure to cadmium and risk of thyroid cancer from national industrial complex areas: a population-based cohort study. Chemosphere. 268:128819.
  • Pathan A, Nariya A, Shah N, Shaikh I, Vyas J, Jhala D. 2017. In vitro amelioration by curcumin on genotoxicity in workers with elevated blood cadmium level. J Nat Remedies. 17(1):20–27.
  • Pawlas N, Płachetka A, Kozłowska A, Mikołajczyk A, Kasperczyk A, Dobrakowski M, Kasperczyk S. 2016. Telomere length, telomerase expression, and oxidative stress in lead smelters. Toxicol Ind Health. 32(12):1961–1970.
  • Pereira S, Cavalie I, Camilleri V, Gilbin R, Adam-Guillermin C. 2013. Comparative genotoxicity of aluminium and cadmium in embryonic zebrafish cells. Mutat Res. 750(1–2):19–26.
  • Peters JL, Sutton AJ, Jones DR, Abrams KR, Rushton L, Moreno SG. 2010. Assessing publication bias in meta-analyses in the presence of between-study heterogeneity. J R Stat Soc Ser A Stat Soc. 173(3):575–591.
  • Pilger A, Rüdiger HW. 2006. 8-Hydroxy-2′-deoxyguanosine as a marker of oxidative DNA damage related to occupational and environmental exposures. Int Arch Occup Environ Health. 80(1):1–15.
  • Rashid S, Arshad M, Siddiqa M, Ahmad R. 2018. Evaluation of DNA damage in traffic police wardens of Pakistan due to cadmium and zinc. Sci Total Environ. 630:1360–1364.
  • Roussel C, Witt KL, Shaw PB, Connor TH. 2019. Meta-analysis of chromosomal aberrations as a biomarker of exposure in healthcare workers occupationally exposed to antineoplastic drugs. Mutat Res Rev Mutat Res. 781:207–217.
  • Ruiz-Ruiz B, Arellano-García ME, Radilla-Chávez P, Salas-Vargas DS, Toledano-Magaña Y, Casillas-Figueroa F, Luna Vazquez-Gomez R, Pestryakov A, García-Ramos JC, Bogdanchikova N. 2020. Cytokinesis-block micronucleus assay using human lymphocytes as a sensitive tool for cytotoxicity/genotoxicity evaluation of AgNPs. ACS Omega. 5(21):12005–12015.
  • Sciskalska M, Zalewska M, Grzelak A, Milnerowicz H. 2014. The influence of the occupational exposure to heavy metals and tobacco smoke on the selected oxidative stress markers in smelters. Biol Trace Elem Res. 159(1–3):59–68.
  • Singh P, Mitra P, Goyal T, Sharma S, Sharma P. 2021. Blood lead and cadmium levels in occupationally exposed workers and their effect on markers of DNA damage and repair. Environ Geochem Health. 43(1):189–193.
  • Su TY, Pan CH, Hsu YT, Lai CH. 2019. Effects of heavy metal exposure on shipyard welders: a cautionary note for 8-hydroxy-2′deoxyguanosine. Int J Environ Res Public Health. 16(23):4813.
  • Taha MM, Mahdy-Abdallah H, Shahy EM, Ibrahim KS, Elserougy S. 2018. Impact of occupational cadmium exposure on bone in sewage workers. Int J Occup Environ Health. 24(3–4):101–108.
  • Taioli E, Frenkel K, Tagesson C, Baranski B, Ganguly S, Karkoszka J, Toniolo P, Cohen B, Garte S. 1998. Molecular markers of exposure to cadmium and nickel among alkaline battery workers. Biomarkers. 3(2):129–140.
  • Tinkov AA, Filippini T, Ajsuvakova OP, Skalnaya MG, Aaseth J, Bjørklund G, Gatiatulina ER, Popova EV, Nemereshina ON, Huang P-T, et al. 2018. Cadmium and atherosclerosis: a review of toxicological mechanisms and a meta-analysis of epidemiologic studies. Environ Res. 162:240–260.
  • Tucker JD, Preston RJ. 1996. Chromosome aberrations, micronuclei, aneuploidy, sister chromatid exchanges, and cancer risk assessment. Mutat Res Rev Genet Toxicol. 365(1–3):147–159.
  • Viau M, Gastaldo J, Bencokova Z, Joubert A, Foray N. 2008. Cadmium inhibits non-homologous end-joining and over-activates the MRE-11-dependent repair pathway. Mutat Res. 654(1):13–21.
  • Waisberg M, Joseph P, Hale B, Beyersmann D. 2003. Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicology. 192(2–3):95–117.
  • Wan X, Wang W, Liu J, Tong T. 2014. Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. BMC Med Res Methodol. 14(1):1–13.
  • Wang Q, He AM, Gao B, Chen L, Yu QZ, Guo H, Shi BJ, Jiang P, Zhang ZY, Li PL, et al. 2011. Increased levels of lead in the blood and frequencies of lymphocytic micronucleated binucleated cells among workers from an electronic-waste recycling site. J Environ Sci Health A Tox Hazard Subst Environ Eng. 46(6):669–676.
  • Wang T, Feng W, Kuang D, Deng Q, Zhang W, Wang S, He M, Zhang X, Wu T, Guo H. 2015. The effects of heavy metals and their interactions with polycyclic aromatic hydrocarbons on the oxidative stress among coke-oven workers. Environ Res. 140:405–413.
  • Wegner R, Radon K, Heinrich-Ramm R, Seemann R, Riess A, Koops F, Poschadel B, Szadkowski D. 2004. Biomonitoring results and cytogenetic markers among harbour workers with potential exposure to river silt aerosols. Occup Environ Med. 61(3):247–253.
  • Wells GA, Shea B, O’Connell D, Peterson J, Welch V, Losos M, Tugwell P. 2014. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa Hosp Res Inst. [accessed 2014 Aug 13]. http://www.ohri.ca/programs/clinical{_}epidemiology/oxford.asp.
  • WHO. 2000. Cadmium, Chapter 6.3. Copenhagen: WHO Regional Office for Europe.
  • Wilson DM, Thompson LH. 2007. Molecular mechanisms of sister-chromatid exchange. Mutat Res. 616(1–2):11–23.
  • Xu J, Wise J, Wang L, Schumann K, Zhang Z, Shi X. 2017. Dual roles of oxidative stress in metal carcinogenesis. J Environ Pathol Toxicol Oncol. 36(4):345–376.
  • Yang D, Liu Y, Liu S, Li C, Zhao Y, Li L, Lu S. 2020. Exposure to heavy metals and its association with DNA oxidative damage in municipal waste incinerator workers in Shenzhen, China. Chemosphere. 250:126289.
  • Youness ER, Mohammed NA, Morsy FA. 2012. Cadmium impact and osteoporosis: mechanism of action. Toxicol Mech Methods. 22(7):560–567.
  • Zhang H, Reynolds M. 2019. Cadmium exposure in living organisms: a short review. Sci Total Environ. 678:761–767.

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