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Original Articles

Milk Biologically Active Components as Nutraceuticals: Review

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Pages 645-656 | Published online: 18 Jan 2007

REFERENCES

  • Adamson , N. J. and Reynolds , E. C. 1995 . Characterization of tryptic casein phosphopeptides prepared under industrially relevant conditions . Biotechnology and Bioengineering , 45 : 196 – 204 . [CSA]
  • Adamson , N. J. and Reynolds , E. C. 1996 . Characterization of casein phosphopeptides prepared using alcalase: Determination of enzyme specificity . Enzyme and Microbial Technology , 19 : 202 – 207 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA] [CROSSREF]
  • Aimutis , W. R. 2004 . Bioactive properties of milk proteins with particular focus on anticariogenesis . Journal of Nutrition , 134 : 989S – 995S . [PUBMED] [INFOTRIEVE] [CSA]
  • Antila , P. , Paakkari , I. , Jarvinen , A. , Mattila , M. J. , Laukkanen , M. , Pihlanto-Leppala , A. , Mantsala , P. and Hellman , J. 1991 . Opioid peptides derived from in vitro proteolysis of bovine whey proteins . International Dairy Journal , 1 : 215 – 229 . [CROSSREF] [CSA] [CROSSREF]
  • Baker , E. N. , Anderson , B. F. , Baker , H. M. , Day , C. L. , Haridas , M. , Norris , G. E. , Rumball , S. V. , Smith , C. A. and Thomas , D. H. 1994 . “ Three-dimensional structure of lactoferrin in various functional states ” . In Advances in Experimental Medicine and Biology , Edited by: Hutchens , T. W. , Rumball , S. V. and Lönnerdal , B. 1 – 12 . New York : Plenum Press .
  • Batish , V. K. , Chander , H. , Zumdegeni , K. C. , Bhatia , K. L. and Singh , R. S. 1988 . Antibacterial activity of lactoferrin against some common food-borne pathogenic organisms . Australian Journal of Dairy Technology , 5 : 16 – 18 . [CSA]
  • Bellamy , W. , Takase , M. , Yamauchi , K. , Wakabayashi , H. , Kawase , K. and Tomita , M. 1992 . Identification of the bactericidal domain of lactoferrin . Biochemica Biophysica. Acta. , 1121 : 130 – 136 . [CSA]
  • Bicknell , R. S. 1985 . Endogenous opioid peptides and hypothalamic neuroendocrine neurons . Scandinavian Endocrinology , 107 : 43 [CSA]
  • Bogsted , A. K. , Johansen , K. , Hatta , R. , Kim , M. , Casswall , M. , Svensson , L. and Hammerström , L. 1996 . Passive immunity against diarrhea . Acta. Pediatrica. , 85 : 125 – 128 . [CSA]
  • Bostwick , E. F. , Steijns , J. and Braun , S. 2000 . “ Lactoglobulins ” . In Natural food antimicrobial systems , Edited by: Naidu , A. S. 133 – 158 . Boca Raton : CRC Press .
  • Brantl , V. , Teschemacher , H. , Bläsíg , J. , Henschen , A. and Lottspeich , F. 1981 . Opioid activities of β-casomorphins . Life Sciences , 28 : 1903 – 1909 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA] [CROSSREF]
  • Brantl , V. , Teschemacher , H. , Henschen , A. and Lottspeich , F. 1979 . Novel opioid peptides derived from casein (β-casomorphins) . Hoppe Seylers Z. Physiol. Chem. , 360 : 1211 – 1216 . [PUBMED] [INFOTRIEVE] [CSA]
  • Britigan , B. E. , Serody , J. S. and Cohen , M. S. 1994 . “ The role of lactoferrin as an anti-inflammatory molecule ” . In Advances in Experimental Medicine and Biology , Edited by: Hutchens , T. W. , Rumball , S. V. and Lönnerdal , B. 143 – 156 . New York : Plenum Press .
  • Brody , E. P. 2000 . Biological activities of bovine glycomacropeptide . British Journal of Nutrition , 84 : S39 – S46 . [PUBMED] [INFOTRIEVE] [CSA]
  • Brommage , R. , Juillerat , M. A. and Jost , R. 1991 . Influence of casein phosphopeptides and lactulose on intestinal calcium absorption in adult female rats . Lait , 71 : 173 – 180 . [CSA]
  • Chang , K. -J. , Su , Y. F. and Brent , D. A. 1985 . Isolation of a specific μ-Opiate receptor peptide, Morphiceptin, from an enzymatic digest of milk proteins . The Journal of Biological Chemistry , 260 : 9706 – 9712 . [PUBMED] [INFOTRIEVE] [CSA]
  • Cheison , S. C. and Wang , Z. 2003 . Bioactive milk peptides: Redefining the food-drug interface—Paper 1: Antimicrobial and immunomodulating peptides . Africa Journal of Food, Agriculture, Nutrition and Development , 3 : 29 – 38 . [CSA]
  • Chiba , H. , Tani , F. and Yoshikawa , M. 1989 . Opioid antagonist peptides derived from κ-casein . Journal of Dairy Research , 56 : 363 – 366 . [PUBMED] [INFOTRIEVE] [CSA]
  • Clare , D. A. and Swaisgood , H. E. 2000 . Bioactive milk peptides: A prospectus . Journal of Dairy Science , 83 : 1187 – 1195 . [PUBMED] [INFOTRIEVE] [CSA]
  • Coddeville , B. , Strecker , G. , Wieruszeski , J. M. , Vliegenthart , J. F.G. , Van Halbeek , H. , Peter-Katalinic , J. , Egge , H. and Spik , G. 1992 . Heterogeneity of bovine lactotransferrin glycans: Characterization of α-D-Gal p-(1- > 3)-β-D-Gal- and α-NeuAc-(2- > 6)-β-D-GalpNAc-(1- > 4)-β-D-GlcNAc-substituted N-linked glycans . Carbohydrate Research , 236 : 145 – 164 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA] [CROSSREF]
  • Daniel , H. , Vohwinkel , M. and Rehner , G. 1990 . Effect of casein and β-casomorphin on gastrointestinal motility in rats . Journal of Nutrition , 120 : 252 – 257 . [PUBMED] [INFOTRIEVE] [CSA]
  • Debbabi , H. , Dubarry , M. , Rautureau , M. and Tomé , D. 1998 . Bovine lactoferrin induces both mucosal and systemic immune response in mice . Journal of Dairy Research , 65 : 283 – 293 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA] [CROSSREF]
  • Diarra , M. S. , Lacasse , P. and Petitclerc , D. Method and composition for treatment and/or prevention of antibiotic-resistant microorganism infections . International Patent Application No. PCT/CA00/01517 . 2001 .
  • Farrell , H. M. Jr. , Jimenez-Flores , R. , Bleck , G. T. , Brown , E. M. , Butler , J. E. , Creamer , L. K. , Hicks , C. L. , Hollar , C. M. , Ng-Kwai-Hang , K. F. and Swaisgood , H. E. 2004 . Nomenclature of the proteins of cows' milk—Sixth Revision . Journal of Dairy Science , 87 : 1641 – 1674 . [PUBMED] [INFOTRIEVE] [CSA]
  • Fiat , A. M. , Migliore-Samour , D. , Jolles , P. , Drouet , I. , Bal Dit Soitier , C. and Caen , J. 1993 . Biologically active peptides from milk proteins with emphasis on two examples concerning antithrombotic and immunomodulating activities . Journal of Dairy Science , 76 : 301 – 310 . [PUBMED] [INFOTRIEVE] [CSA]
  • Fox , P. F. 2001 . Milk proteins as food ingredients . International Journal of Diary Technology , 54 : 41 – 55 . [CROSSREF] [CSA] [CROSSREF]
  • Fox , P. F. and McSweeney , P. L.H. 2001 . Advanced Dairy Chemistry: 1. Proteins. , 2nd ed. , Gaithersburg, MD : Aspen Publishers, Inc .
  • Gobetti , M. , Stepaniak , L. , De Angelis , M. , Corsetti , A. and Di Cagno , R. 2002 . Latent bioactive peptides in milk proteins: Proteolytic activation and significance in diary processing . Critical Reviews in Food Science and Nutrition , 42 : 223 – 239 . [CROSSREF] [CSA] [CROSSREF]
  • Greenberg , R. , Groves , M. L. and Dower , H. J. 1984 . Human beta-casein. Amino acid sequence and identification of phosphorylation sites . J. Biol. Chem. , 259 : 5132 – 5138 . [PUBMED] [INFOTRIEVE] [CSA]
  • Grenby , T. H. , Andrews , A. T. , Mistry , M. and Williams , R. J.H. 2001 . Dental caries-protective agents in milk products: Investigations in vitro . Journal of Dentistry , 29 : 83 – 92 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA] [CROSSREF]
  • Hansen , M. , Sandström , B. and Lönnerdal , B. 1996 . The effect of casein phosphopeptides on zinc and calcium absorption from high phytate infant diets assessed in rat pups and caco-2 cells . Pediatric Research , 40 : 547 – 552 . [PUBMED] [INFOTRIEVE] [CSA]
  • Hansen , M. , Sandström , B. , Jensen , M. and Sörensen , S. S. 1997 . Casein phosphopeptides improve zinc and calcium absorption from rice-based but not from whole-grain infant cereal . Journal of Pediatric Gastroenterology and Nutrition , 24 : 56 – 62 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA] [CROSSREF]
  • Harmsen , M. C. , Swart , P. J. , DeBéthune , M. P. , Pauwels , R. , De Clercq , E. , Hauw , T. and Meijer , D. K.F. 1995 . Antiviral effects of plasma and milk proteins: Lactoferrin shows potent activity against both human immunodeficiency virus and human cytomegalovirus replication in vitro . Journal of Infectious Diseases , 172 : 380 – 388 . [PUBMED] [INFOTRIEVE] [CSA]
  • Haukland , H. H. , Ulvatne , H. , Sandvik , K. and Vorland , L. H. 2001 . The antibacterial peptides lactoferricin B and Magainin 2 cross over the bacterial cytoplasmic membrane and reside in the cytoplasm . FEBS Lett. , 508 : 389 – 393 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA] [CROSSREF]
  • Heany , R. P. , Saito , Y. and Orimo , H. 1994 . Effect of casein phosphopeptide on absorbability of co-ingested calcium in normal postmenopausal women . Journal of Bone Mineral Metabolism , 12 : 77 – 81 . [CSA]
  • Henschen , A. , Lottspeich , F. , Brantl , V. and Teschemacher , H. 1979 . Novel opioid peptides derived from casein, β-casomorphins. II. Structure of active components from bovine casein peptone . Hoppe-Seyler's Physiol. Chem. , 360 : 1217 – 1224 . [CSA]
  • Hirayama , M. , Toyota , K. , Hidaka , H. and Naito , H. 1992 . Phosphopeptides in rat intestinal digests after ingesting casein phosphopeptides . Bioscience Biotechnology Biochemistry , 56 : 112 – 1129 . [CSA]
  • Holt , C. and Horne , D. S. 1996 . The hairy casein micelle: Evolution of the concept and its implications for dairy technology . Netherlands Milk & Dairy Journal , 50 : 85 – 112 . [CSA]
  • Hutchens , T. W. , Rumball , S. V. and Lonnerdal , B. 1994 . Lactoferrin: Structure and function . Advances in Experimental Medical and Biological , 357 : 1 – 298 . [CSA]
  • Jan , M. S. 2001 . Milk ingredients as nutraceuticals . International Journal of Dairy Technology , 54 : 81 – 88 . [CROSSREF] [CSA] [CROSSREF]
  • Jollès , P. 1975 . Structural aspects of the milk clotting process. Comparative features with the blood clotting process . Mol. Cell. Biochem. , 7 : 73 [CROSSREF] [CSA] [CROSSREF]
  • Jollès , P. and Henschen , A. 1982 . Comparison between the clotting of blood and milk . Trends Biochem. Sci. , 7 : 325 [CROSSREF] [CSA] [CROSSREF]
  • Jollès , P. , Loucheux-Lefebvre , M. H. and Hanschen , A. 1978 . Structural relatedness of κ-casein and fibrinogen γ-chain . J. Mol. Evol. , 11 : 271 [CROSSREF] [CSA] [CROSSREF]
  • Jones , E. M. , Smart , A. , Bloomberg , G. , Burgess , L. and Millar , M. R. 1994 . Lactoferricin, a new antimicrobial peptide . Journal of Applied Bacteriology , 77 : 208 – 214 . [PUBMED] [INFOTRIEVE] [CSA]
  • Kelley , C. P. , Chetman , S. , Keates , S. , Bostwick , E. F. , Roush , A. M. , Castagliuolo , I. , Lamont , J. T. and Pothoulakis , C. 1997 . Survival of anti-Clostridium difficile bovine immunoglobulin concentrate in the human gastrointestinal tract . Antimicrobial Agents and Chemotherapy , 41 : 236 – 241 . [CSA]
  • Kelly , P. M. , Kelly , J. , Mchra , R. , Oldfield , D. J. , Raggett , E. and O'Kennedy , B. T. 2000 . Implementation of integrated membrane processes for pilot scale development of fractionated milk components . Lait , 80 : 139 – 153 . [CROSSREF] [CSA] [CROSSREF]
  • Kohmura , M. , Nio , N. and Ariyoshi , Y. 1990 . Inhibition of angiotensin I-converting enzyme by synthetic peptides of human κ-casein . Agric. Biol. Chem. , 54 : 835 – 836 . [PUBMED] [INFOTRIEVE] [CSA]
  • Kohmura , M. , Nio , N. , Kubo , K. , Minoshima , Y. , Munekata , E. and Ariyoshi , Y. 1989 . Inhibition of angiotensin I-converting enzyme by synthetic peptides of human β-casein . Agric. Biol. Chem. , 53 : 2107 – 2114 . [CSA]
  • Korhonen , H. 1977 . Antimicrobial factors in bovine colostrum . Journal of the Scientific Agricultural Society of Finland , 49 : 434 – 447 . [CSA]
  • Korhonen , H. , Pihlanto-Leppala , A. , Rantamaki , P. and Tupasela , T. 1998 . The functional and biological properties of whey proteins: prospects for the development of functional foods . Agriculture and Food Science in Finland , 7 : 283 – 296 . [CSA]
  • Kulkarni , P. R. and Pimpale , N. V. 1989 . Colostrum—A review . Indian Journal of Dairy Science , 42 : 216 – 224 . [CSA]
  • Kussendrager , K. 1993 . Lactoferrin and lactoperoxidase: Bioactive milk proteins . International Food Ingredients , 6 : 17 – 21 . [CSA]
  • Lahov , E. and Regelson , W. 1996 . Antibacterial and immunostimulating caseinderived substances from milk: Caseicidin, isracidin peptides . Food and Chemical Toxicology , 34 : 131 – 145 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA] [CROSSREF]
  • Lee , Y. S. , Noguchi , G. and Naito , H. 1980 . Phosphopeptides and soluble calcium in the small intestine of rats given a casein diet . British Journal of Nutrition , 43 : 457 – 467 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA] [CROSSREF]
  • Lindsay , S. , Paul , N. B. , Michael , J. B. , Lawrence , K. C. , Helen , D. , Patrick , J. B.E. , Carl , H. , Geoffrey , B. J. , George , K. , Gillian , E. N. , Stanislava , U. and Su-Ying , W. 2002 . Milk protein structure—What can it tell the dairy industry? . International Dairy Journal , 12 : 299 – 310 . [CSA]
  • Loukas , L. , Varoucha , D. , Zioudron , C. , Straty , R. A. and Klee , W. A. 1983 . Opioid activities and structures of alpha-casein-derived exorphins . Biochemistry , 22 : 4567 – 4573 . [PUBMED] [INFOTRIEVE] [CSA]
  • Luo , S. J. and Wong , L. L. Oral care chewing gums and confections . International Patent Application No. PCT/US00/02142 . 2000 .
  • Maeno , M. , Yamamoto , N. and Takano , T. 1996 . Identification of an antihypertensive peptide from casein hydrolysate produced by a proteinase from Lactobacillus heleveticus CP790 . J. Dairy Science , 79 : 1316 – 1321 . [CSA]
  • Marchetti , M. , Longhi , C. , Conte , M. P. , Pisani , S. , Valenti , P. and Seganti , L. 1977 . Lactoferrin inhibits herpes simplex virus type I adsorption to Vero cells . Antiviral Research , 29 : 221 – 231 . [CROSSREF] [CSA] [CROSSREF]
  • Maruyama , S. and Suzuki , H. 1982 . A peptide inhibitor of angiotensin I-converting enzyme in the tryptic hydrolysate of casein . Agric. Biol. Chem. , 46 : 1393 – 1394 . [CSA]
  • McIntosh , G. H. , Jorgensen , L. and Royle , P. J. 1993 . The potential of an insoluble dietary fibre-rich source from barley to protect from DMH-induced intestinal tumors in rats . Nutrition and Cancer , 19 : 213 [PUBMED] [INFOTRIEVE] [CSA]
  • McIntosh , G. H. , Regester , G. O. , Le Leu , R. K. , Royle , P. J. and Smithers , G. W. 1995 . Dairy proteins protect against dimethylhydrazine-induced intestinal tumors in rats . Journal of Nutrition , 125 : 809 – 816 . [PUBMED] [INFOTRIEVE] [CSA]
  • McLeod , A. , Fedio , W. , Chu , L. and Ozimek , L. 1996 . Binding of retionoic acid to β-lactoglobulin variants A and B: Effect of hepatic and tryptic digestion on the protein-ligand complex . Milchwissenschaft , 51 : 3 – 7 . [CSA]
  • Meisel , H. 1997 . Biochemical properties of regulatory peptides derived from milk proteins . Biopolymers , 43 : 119 – 128 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA] [CROSSREF]
  • Meisel , H. and Frister , H. 1989 . Chemical characterization of bio-active peptides from in vivo digests of casein . Journal of Dairy Research , 56 : 343 – 349 . [PUBMED] [INFOTRIEVE] [CSA]
  • Meisel , H. , Goepfert , A. and Günther , S. 1997 . ACE-inhibitory activities in milk products . Milchwissenschaft , 52 : 307 – 311 . [CSA]
  • Migliore-Samour , D. , Floch , F. and Jolles , P. 1989 . Biologically active casein peptides implicated in immunomodulation . Journal of Dairy Research , 56 : 357 [PUBMED] [INFOTRIEVE] [CSA]
  • Modler , H. W. 2000 . “ Milk processing ” . In Food Proteins: Processing Applications , Edited by: Nakai , S. and Modler , H. W. 1 – 88 . New York : Willey .
  • Moore , S. A. , Anderson , B. F. , Groom , C. R. , Haridas , M. and Baker , E. N. 1997 . Three-dimensional structure of diferric bovine lactoferrin at 2.8 Å resolution . Journal of Molecular Biology , 274 : 222 – 236 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA] [CROSSREF]
  • Mullally , M. M. , Meisel , H. and Fitzgerald , R. J. 1996 . Synthetic peptides corresponding to alpha-lactalbumin and beta-lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity . Biological Chemistry Hoppeseyler , 377 : 259 – 260 . [CSA]
  • Mullally , M. M. , Meisel , H. and Fitzgerald , R. J. 1997 . Identification of a novel angiotensin-I-converting enzyme inhibitory peptide corresponding to tryptic fragment of bovine beta-lactoglobulin . FEBS Letters , 402 : 99 – 101 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA] [CROSSREF]
  • Nagendra , P. S. 2000 . Effects of milk-derived bioactives: An overview . British Journal of Nutrition , 84 : S3 – S10 . [CSA]
  • Naito , H. and Suzuki , H. 1974 . Further evidence for the formation in vivo of phosphopeptide in the intestinal lumen from dietary β-casein . Agricultural and Biological Chemistry , 38 : 1543 – 1545 . [CSA]
  • Nakamura , Y. , Yamamoto , N. , Kumi , S. and Takano , T. 1995 . Antihypertensive effect of sour milk and peptides isolated from it that are inhibitors to angiotensin-I converting enzyme . Journal of Dairy Science , 78 : 1253 – 1257 . [PUBMED] [INFOTRIEVE] [CSA]
  • Newburg , D. S. and Newbauer , S. H. 1995 . “ Carbohydrates in milk ” . In Handbook of Milk Composition , Edited by: Jensen , R. G. 273 – 349 . San Diego : Academic Press .
  • Newburg , D. S. , Pickering , L. K. , McCluer , R. H. and Cleary , T. G. 1990 . Fucosylated oligosaccharides of human milk protect sucling mice from heat stable enterotoxin of Escherichia coli . Journal of Infectious Diseases , 162 : 1075 – 1080 . [PUBMED] [INFOTRIEVE] [CSA]
  • Nibbering , P. H. , Ravensbergen , E. , Welling , M. M. , Van Berkel , L. A. , Van Berkel , P. H.C. , Pauwels , E. K. and Nuijens , J. H. 2001 . Human lactoferrin and peptides derived from its N-Terminus are highly effective against infections with antibiotic resistant bacteria . Infection and Immunity , 69 : 1469 – 1476 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA] [CROSSREF]
  • Pariza , M. W. Conjugated linoleic acid: A newly recognized nutrient . IFT Annual Meeting . Orlando, FL. pp. 15 – 3 . Abstract
  • Parker , F. , Migliore-Samour , D. , Floch , F. , Zerial , A. , Werner , G. H. , Jolles , J. , Casaretto , M. , Zahn , H. and Jolles , P. 1984 . Immunostimulating hexapeptide from human casein: Amino acid sequence, synthesis, and biological properties . European Journal of Biochemistry , 145 : 677 [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA] [CROSSREF]
  • Paroli , E. 1988 . Opioid peptides from food (the exorphins) . World Rev. Nutr. Diet , 55 : 58 – 97 . [PUBMED] [INFOTRIEVE] [CSA]
  • Payne , K. D. , Davidson , P. M. and Oliver , S. P. 1990 . Influence of bovine lactoferrin on the growth of Listeria monocytogenes . Journal of Food Protection , 53 : 468 – 472 . [CSA]
  • Petrilli , P. , Addeo , F. and Chianese , L. 1983 . Primary structure of water buffalo beta-casein tryptic and CNBr peptides . Ital. J. Biochem. , 32 : 336 – 344 . [PUBMED] [INFOTRIEVE] [CSA]
  • Pierce , A. , Colavizza , D. , Benaissa , M. , Maes , P. , Tartra , A. , Montreuil , J. and Spik , G. 1991 . Molecular cloning and sequence analysis of bovine lactoferrin . European Journal of Biochemistry , 196 : 177 – 184 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA] [CROSSREF]
  • Pihlanto-Leppälä , A. 2001 . Bioactive peptides derived from bovine whey proteins: Opioid and ACE-Inhibitory peptides . Trends in Food Science & Technology , 11 : 347 – 356 . [CROSSREF] [CSA] [CROSSREF]
  • Pihlanto-Leppala , A. , Antila , P. , Mantsala , P. and Hellamn , J. 1994 . Opioid peptides produced by in vivo proteolysis of bovine caseins . Int. Dairy J. , 4 : 291 – 301 . [CROSSREF] [CSA] [CROSSREF]
  • Pointillart , A. and Gueguen , L. 1989 . Effect of casein phosphopeptides on calcium and phosphorous utilization in growing pigs . Reproduction Nutrition Development , 29 : 477 – 486 . [CSA]
  • Reddy , N. R. , Roth , S. M. , Eigel , W. N. and Pierson , M. D. 1988 . Foods and food ingredients for prevention of diarrheal disease in children in developing countries . Journal of Food Protection , 51 : 66 – 75 . [CSA]
  • Regester , G. O. , McIntosh , G. H. , Lee , V. W.K. and Smithers , G. W. 1996 . Whey proteins as nutritional and functional food ingredients . Food Australia , 48 : 123 – 126 . [CSA]
  • Reynolds , E. C. , Riley , P. F. and Adamson , N. J. 1994 . A selective purification precipitation procedure for multiple phosphoseryl-containing peptides and methods for their identification . Anal. Biochem. , 217 : 277 – 284 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA] [CROSSREF]
  • Richardson , B. C. and Mercier , J. C. 1979 . The primary structure of the ovine beta-caseins . Eur. J. Biochem. , 99 : 285 – 297 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA] [CROSSREF]
  • Roos , N. , Mahé , S. , Benamouzig , R. , Sick , H. , Rautureau , J. and Tomé , D. 1995 . 15N-labelled immunoglobulins from bovine colostrum are partially resistant to digestion in human intestine . Journal of Nutrition , 125 : 1238 – 1244 . [PUBMED] [INFOTRIEVE] [CSA]
  • Saito , H. , Miyakawa , H. , Tamura , Y. , Shimamura , S. and Tomita , M. 1991 . Potent bacteriocidal activity of bovine lactoferrin hydrolysate reproduced by heat treatment at acidic pH . Journal of Dairy Science , 74 : 3724 – 3730 . [PUBMED] [INFOTRIEVE] [CSA]
  • Sakai , M. , Kobayashi , M. and Yoshida , T. 1995 . Activation of rainbow trout, Oncorhynchus mykiss, phagocytic cells by administration of bovine lactoferrin . Comparative Biochemistry and Physiology , 110 ( B ) : 755 – 759 . [CSA]
  • Sato , R. , Inanami , O. , Tanak , Y. , Takase , M. and Naito , Y. 1996 . Oral administration of bovine lactoferrin for treatment of intractable stomatitis in feline immunodeficiency virus (FIV)-positive and FIV-negative cats . American Journal of Veterinary Research , 57 : 1443 – 1446 . [PUBMED] [INFOTRIEVE] [CSA]
  • Sato , R. , Noguchi , T. and Naito , H. 1986 . Casein phosphopeptide (CPP) enhances calcium absorption from the ligated segment of rat small intestine . Journal of Nutrition Science and Vitaminology , 32 : 67 – 76 . [CSA]
  • Schlimme , E. and Meisel , H. 1995 . Bioactive peptides derived from milk proteins: Structural, physiological, and analytical aspects . Die Nahrung , 39 : 1 – 20 . [PUBMED] [INFOTRIEVE] [CSA]
  • Schmelz , E. M. and Merrill , A. H. Milk sphingolipids: A new category of functional food . IFT Annual Meeting . Orlando, FL. pp. 15 – 4 . Abstract
  • Scholz-Ahrens , K. E. and Schrezenmeir , J. 2000 . Effects of bioactive substances in milk on mineral and trace element metabolism with special reference to casein phosphopeptides . British Journal of Nutrition , 84 : S147 – S153 . [PUBMED] [INFOTRIEVE] [CSA]
  • Scholz-Ahrens , K. E. , Kopra , N. and Barth , C. A. 1990 . Effect of casein phosphopeptides on utilization of calcium in minipigs and vitamin-D deficient rats . Zeitschrift für Ernährungswissenschaft , 29 : 295 – 298 . [CSA]
  • Sekiya , S. , Kobayashi , Y. , Kita , E. , Imamura , Y. and Toyama , S. 1996 . Antihypertensive effects of tryptic hydrolysates of casein on normotensive and hypertensive volunteers . Journal of Japanese Society of Nutrition and Food Science , 45 : 513 [CSA]
  • Seppo , L. , Jauhiainen , T. , Poussa , T. and Korpela , R. 2003 . A fermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjects . Am. J. Clin. Nutr. , 77 : 326 – 330 . [PUBMED] [INFOTRIEVE] [CSA]
  • Shin , K. , Yamauchi , K. , Teraguchi , S. , Hayasawa , H. , Tomita , M. , Otsuka , Y. and Yamazaki , S. 1998 . Antibacterial activity of bovine lactoferrin and its peptides against enterohaemorrhagic Escherichia coli 0157:H7 . Letters on Applied Microbiology , 6 : 407 – 411 . [CROSSREF] [CSA] [CROSSREF]
  • Silva , H. E.R. and Verdalet , G. I. 2003 . Functional foods and ingredients derived from milk . Arch. Latinoam. Nutr. , 53 : 333 – 347 . [CSA]
  • Smacchi , E. and Gobbetti , M. 2000 . Bioactive peptides in dairy products: Synthesis and interaction with proteolytic enzyme . Food Microbiology , 17 : 129 – 141 . [CROSSREF] [CSA] [CROSSREF]
  • Spik , G. , Coddeville , B. , Mazurier , J. , Bourne , Y. , Cambillaut , C. and Montreuil , J. 1994 . “ Primary and three-dimensional structure of lactotransferrin (lactoferrin) glycans ” . In Advances in Experimental Medicine and Biology , Edited by: Hutchens , T. W. , Rumball , S. V. and Lönnerdal , B. 21 – 32 . New York : Plenum Press .
  • Steijns , J. M. and Van Hooijdonk , A. C.M. 2000 . Occurrence, structure, biochemical properties and technological characteristics of lactoferrin . British Journal of Nutrition , 84 : S1 – S8 . [CSA]
  • Superti , F. , Ammendolia , M. G. , Valenti , P. and Seganti , I. 1989 . Antirotaviral activity of milk proteins: Lactoferrin prevents rotavirus infection in the enterocyte-like cell line HT-29 . Medical Microbiology and Immunology , 186 : 83 – 91 . [CROSSREF] [CSA] [CROSSREF]
  • Suzuki , T. , Yamauchi , K. , Kawase , K. , Tomita , M. , Kiyasawa , I. and Okongi , S. 1997 . Collaborative bacteriostatic activity of bovine lactoferrin with lysozyme against E. coli 0111 . Agriculture and Biological Chemistry , 53 : 1705 – 1706 . [CSA]
  • Svedberg , J. , De Haas , J. , Leimenstoll , G. , Paul , F. and Teschemacher , H. 1985 . Demonstration of β-casomorphin immunoreactive materials in in vivo digests of bovine milk and in small intestine contents after bovine milk ingestion in adults humans . Peptides , 6 : 625 [CROSSREF] [CSA] [CROSSREF]
  • Tani , F. , Iio , K. , Chiba , H. and Yoshikawa , M. 1990 . Isolation and characterization of opioid antagonist peptides derived from human lactoferrin . Agr. Biol. Chem. , 54 : 1803 – 1810 . [CSA]
  • Tani , F. , Shiota , H. , Chiba , H. and Yoshikawa , M. 1994 . “ Serophin, an opioid peptide derived from serum albumin ” . In β-Casomorphins and related peptides: Recent developments , Edited by: Brantl , V. and Teschemacher , H. 49 – 53 . Germany : VCH-Weinheim .
  • Tomita , M. , Bellamy , W. R. , Takase , M. , Yamauchi , K. , Wakabayashi , H. and Kawase , K. 1991 . Potent antibacterial peptides generated by pepsin digestion of bovine lactoferrin . Journal of dairy Science , 74 : 4137 – 4142 . [PUBMED] [INFOTRIEVE] [CSA]
  • Tsuchita , H. , Goto , T. , Shimizu , T. , Yonehara , Y. and Kuwata , T. 1996 . Dietary casein phosphopeptides prevent bone loss in aged ovariectomized rats . Journal of Nutrition , 126 : 86 – 93 . [PUBMED] [INFOTRIEVE] [CSA]
  • Tsuchita , H. , Suzuki , T. and Kuwata , T. 2001 . The effect of casein phosphopeptides on calcium absorption from calcium-fortified milk in growing rats . British Journal of Nutrition , 85 : 5 – 10 . [PUBMED] [INFOTRIEVE] [CSA]
  • Tsuji , S. , Hirata , Y. , Mukai , F. and Ohtagaki , S. 1990 . Comparison of lactoferrin content in colostrum between different cattle breeds . Journal of Dairy Science , 73 : 125 – 128 . [PUBMED] [INFOTRIEVE] [CSA]
  • Van der Meer , R. and Lapre , J. A. 1991 . Calcium and colon cancer . Bulletin of the International Dairy Federation , 255 : 55 – 59 . [CSA]
  • Van der Ven , C. 2002 . Biochemical and functional characterization of casein and whey protein hydrolysates. A study on the correlations between biochemical and functional properties using multivariate data analysis , Ph.D thesis The Netherlands : Wageningen University .
  • Vannini , L. , Lanciotti , R. , Baldi , D. and Guerzoni , M. E. 2004 . Interactions between high pressure homogenization and antimicrobial activity of lysozyme and lactoperoxidase . International Journal of Food Microbiology , 94 : 123 – 135 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Viljoen , M. 1995 . Lactoferrin: A general review . Haematologica , 80 : 252 – 267 . [PUBMED] [INFOTRIEVE] [CSA]
  • Visalsok , T. , Shigeru , H. , Satoshi , Y. and Souichi , K. 2004 . Effects of a lactoperoxidase-thiocyanate-hydrogen peroxide system on Salmonella enteritidis in animal or vegetable foods . International Journal of Food Microbiology , 93 : 175 – 183 . [CSA] [CROSSREF]
  • Walstra , P. and Jenness , R. 1984 . Dairy chemistry and physics , New York : John Willey & Sons, Inc. .
  • Walzem , R. L. , Dillard , C. J. and German , J. B. 2002 . Whey components: Millennia of evolution create functionalities for mammalian nutrition: What we know and what we may be overlooking . Critical Reviews in Food Science and Nutrition , 42 : 353 – 375 . [PUBMED] [INFOTRIEVE] [CSA]
  • Warner , E. A. , Kanekanian , A. D. and Andrews , A. T. 2001 . Bioactivity of milk proteins: 1. Anticariogenicity of whey proteins . International Journal of Dairy Technology , 54 : 151 – 153 . [CSA] [CROSSREF]
  • Weiner , C. , Pan , Q. , Hurtif , M. , Boren , T. , Bostwick , E. and Hammerström , L. 1999 . Passive immunity against human pathogens using bovine antibodies . Clinical Experimental Immunology , 116 : 193 – 205 . [CSA] [CROSSREF]
  • Wong , C. W. and Watson , D. L. 1995 . Immunomodulatory effects of dietary whey proteins in mice . Journal of Dairy Research , 62 : 359 – 368 . [PUBMED] [INFOTRIEVE] [CSA]
  • Wu , J. P. and Ding , X. L. 2002 . Characterization of inhibitory and stability of soy protein-derived Angiotensin-I-Converting Enzyme inhibitory peptides . Food Research International , 35 : 367 – 375 . [CSA] [CROSSREF]
  • Yamauchi , K. 1992 . Biologically functional proteins of milk and peptides derived from milk proteins . Bulletin of the International Dairy Federation , 272 : 51 [CSA]
  • Yen , S. S.C. , Quingley , M. E. , Reid , R. L. , Ropert , J. F. and Cetei , N. S. 1985 . Neuroendocrinology of opioid peptides and their role in the control of gonadotrophin and prolactin secretion . American Journal of Obstetrics and Gynaecology , 152 : 485 [CSA]
  • Yolken , R. H. , Peterson , J. A. , Vonderfech , S. L. , Fouts , E. T. , Midthun , K. and Newburg , D. S. 1991 . Human milk mucin inhibits rotavirus replication and prevents experimental gastroenteritis . Journal of Clinical Investigation , 90 : 1984 – 1991 . [CSA]
  • Yoshikawa , M. , Tani , F. , Yoshimura , T. and Chiba , H. 1986 . Opioid peptides from milk protein . Agric. Biol. Chem. , 50 : 2419 – 2421 . [CSA]
  • Yoshikawa , M. , Yoshimura , T. and Chiba , H. 1984 . Opioid peptides from human β-casein . Agric. Biol. Chem. , 48 : 3185 – 3187 . [CSA]
  • Yuan , Y. V. and Kitts , D. D. 1991 . Confirmation of calcium absorption and femoral utilization in spontaneously hypertensive rats fed casein phosphopeptide diets . Nutrition Research , 11 : 1257 – 1272 . [CSA]
  • Zioudrou , C. , Streaty , R. A. and Klee , W. A. 1979 . Opioid peptides derived from food. The exorphins . J. Biol. Chem. , 254 : 2446 – 2449 . [PUBMED] [INFOTRIEVE] [CSA]

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