Bioactive volatile fraction of Chilean boldo (Peumus boldus Molina) – an overview

References

• P. O’Brien, C. Carrasco-Pozo and H. Speisky, Boldine and its antioxidant or health-promoting properties. Chemico-Biological Interactions, 159, 1–17 (2006).
   PubMed Web of Science ®Google Scholar
• J.M. Bandeira, Composição do óleo essencial de quarto espécies do gênero Plectranthus. Essential oil composition of four Plectranthus species. Revista Brasileira de Plantas Medicinais, 13(2), 157–164 (2011).
   Google Scholar
• H. Speisky and B.K. Cassels, Boldo and boldine: an emerging case of natural drug development. Pharmacological Research, 29(1), 1–10 (1994).
   PubMed Web of Science ®Google Scholar
• M.G.L. Brandão, G.P. Cosenza, R.A. Moreira and R.L.M. Monte-Mor, Medicinal plants and other botanical products from the Brazilian Official Pharmacopoeia. Revista Brasileira De Farmacognosia, 16(3), 408–420 (2006).
   Google Scholar
• Internet: brasil, Política Nacional de Fitoterápicos e o Impacto nas Farmácias (Ministério da Saúde). Brazil, National Policy of Phytoterapics and the Impact on Pharmacies. (2008). Downloaded from http://bvsms.saude.gov.br/bvs/palestras/cancer/politica_nacional_fititerapicos.pdf ( 15 November 2017).
   Google Scholar
• A.L.T.G. Ruiz, D. Tafarrelo, V.H.S. Souza and J.E. Carvalho, Farmacologia e toxicologia de Peumus boldus e Baccharis genistelloides. Pharmacology and toxicology of Peumus boldus and Baccharis genistelloides. Revista Brasileira de Farmacognosia, 18(2), 295–300 (2008).
   Google Scholar
• H. Vogel, B. González and I. Razmilic, Boldo (Peumus boldus) cultivated under different light conditions, soil humidity and plantation density. Industrial Crops and Products, 34, 1310–1312 (2011).
   Web of Science ®Google Scholar
• N. Quezada, M. Asencio, J.M. Del Valle, J.M. Aguilera and B. Gomez, Antioxidant activity of crude extract, alkaloid fraction, and flavonoid fraction from boldo (Peumus boldus Mol.) leaves. Journal of Food Science, 69(5), 371–376 (2004).
   Web of Science ®Google Scholar
• P. Pietta, P. Mauri, E. Manera and P. Ceva, Determination of isoquinoline alkaloids from Peumus boldus by high-performance liquid chromatography. Journal of Chromatography A, 457, 442–445 (1988).
   Web of Science ®Google Scholar
• D. Basila and C.-S. Yuan, Effects of dietary supplements on coagulation and platelet function. Thrombosis Research, 117(1–2), 49–53 (2005).
   PubMed Web of Science ®Google Scholar
• J.M. Barbosa-Filho, M.R. Piuvezam, M.D. Moura, M.S. Silva, K.V.B. Lima, E.V.L. Cunha, I.M. Fechine and O.S. Takemura, Anti-inflammatory activity of alkaloids: a twenty century review. Revista Brasileira de Farmacognosia, 16, 109–139 (2006).
   Google Scholar
• E.R. Almeida, A.M. Melo and H. Xavier, Toxicological evaluation of the hydro-alcohol extract of the dry leaves of Peumus boldus and boldine in rats. Phytotheraphy Research, 14, 99–102 (2000).
   PubMed Web of Science ®Google Scholar
• M.J. Simirgiotis and G. Schmeda-Hirschmann, Direct identification of phenolic constituents in Boldo Folium (Peumus boldus Mol.) infusions by high-performance liquid chromatography with diode array detection and electrospray ionization tandem mass spectrometry. Journal of Chromatography A, 1217, 443–449 (2010).
   PubMed Web of Science ®Google Scholar
• J.M. Del Valle, T. Rogalinski, C. Zetzl and G. Brunner, Extraction of boldo (Peumus boldus M.) leaves with supercritical CO2 and hot pressurized water. Food Research International, 38, 203–213 (2005).
   Web of Science ®Google Scholar
• R.V. Bluma and M.G. Etcheverry, Application of essential oils in maize grain: impact on Aspergillus section Flavi growth parameters and aflatoxin accumulation. Food Microbiology, 25(2), 324–334 (2008).
   PubMed Web of Science ®Google Scholar
• M. Mazutti, A.J. Mossi, R.L. Cansian, M.L. Corazza, C. Dariva and J.V. Oliveira, Chemical Profile and antimicrobial activity of boldo (Peumus boldus Molina) extracts obtained by compressed carbon dioxide extraction. Brazilian Journal of Chemical Engineering, 25(2), 427–434 (2008).
   Web of Science ®Google Scholar
• M. Bittner, M.A. Aguilera, V. Hernández, C. Arbert, J. Becerra and M.E. Casanueva, Fungistatic activity of essential oils extracted from Peumus boldus Mol., Laureliopsis philippiana (Looser) Schodde and Laurelia sempervirens (Ruiz & Pav.) Tul. (Chilean Monimiaceae. Chilean Journal of Agricultural Research, 69(1), 30–37 (2009).
   Web of Science ®Google Scholar
• A. Urzúa, R. Santander, J. Echeverría, C. Villalobos, S.M. Palacios and Y. Rossi, Insecticidal properties of peumus boldus mol. essential oil on the house fly, musca domestica L. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 9(6), 465–469 (2010).
   Web of Science ®Google Scholar
• M. Verdeguer, D. García-Rellán, H. Boira, E. Pérez, S. Gandolfo and M.A. Blázquez, Herbicidal activity of peumus boldus and drimys winterii essential oils from Chile. Molecules, 16, 403–411 (2011).
   PubMed Web of Science ®Google Scholar
• M.A. Passone and M. Etcheverry, Antifungal impact of volatile fractions of Peumus boldus and Lippia turbinata on Aspergillus section Flavi and residual levels of these oils in irradiated peanut. International Journal of Food Microbiology, 168, 17–23 (2014).
   PubMed Web of Science ®Google Scholar
• L. Petigny, S. Périno, M. Minuti, F. Visinoni, J. Wajsman and F. Chemat, Simultaneous microwave extraction and separation of volatile and non-volatile organic compounds of boldo leaves. From lab to industrial scale. International Journal of Molecular Sciences, 15, 7183–7198 (2014).
   PubMed Web of Science ®Google Scholar
• R. Vila, L. Valenzuela, H. Bello, S. Canigueral, M. Montes and T. Adzet, Composition and antimicrobial activity of the essential oil of Peumus boldus leaves. Planta Medica, 65(2), 178–179 (1999).
   PubMed Web of Science ®Google Scholar
• R.W. Bussmann, A. Glenn and D. Sharon, Antibacterial activity of medicinal plants of Northern Peru – can traditional applications provide leads for modern science? Indian Journal of Traditional Knowledge, 9(4), 742–753 (2010).
   Web of Science ®Google Scholar
• D. Macdonald, K. Vancrey, P. Harrison, P.K. Rangachari, J. Rosenfeld, C. Warren and G. Sorger, Ascaridole-less infusions of Chenopodium ambrosioides contain a nematocide(s) that is(are) not toxic to mammalian smooth muscle. Journal of Ethnopharmacology, 92(2), 215–221 (2004).
   PubMed Web of Science ®Google Scholar
• V. Dembitsky, I. Shkrobb and L.O. Hanus, Ascaridole and related peroxides from the genus chenopodium. Biomedical Papers, 152(2), 209–215 (2008).
   PubMed Web of Science ®Google Scholar
• D.P. Bezerra, J.D.B. Marinho Filho, A.P.N.N. Alves, C. Pessoa, M.O. Moraes, O.D.L. Pessoa, M.C.M. Torres, E.R. Silveira, F.A. Viana and L.V. Costa-Lotufo, Antitumor activity of the essential oil from the leaves of croton regelianus and its component ascaridole. Chemistry & Biodiversity, 6(8), 1224–1232 (2009).
   PubMed Web of Science ®Google Scholar
• G.I.S. Aguayo, Actividad de polvo, extractos y aceite essencial de Peumus boldus Molina solos y en mezcla con Bacillus thuringiensis Berliner contra Spodoptera frugiperda (J.E. Smith) y Helicoverpa zea (Boddie). Ph.D. Thesis, Colegio de Postgraduados – Institución de Enseñanza e Investigación en Ciencias Agrícolas, Montecillo (2010).
   Google Scholar
• S.R. Sargenti and F.M. Lancas, Supercritical fluid extraction of Peumus boldus (Molina. Journal of High Resolution Chromatography, 20, 511–515 (1997).
   Google Scholar
• H. Vogel, I. Razmilic, M. Munoz, U. Doll and J. San Martin, Studies of genetic variation of essential oil and alkaloid content in boldo (Peumus boldus. Planta Medica, 65(1), 90–91 (1999).
   PubMed Web of Science ®Google Scholar
• H. Vogel, I. Razmilic, P. Acevedo and B. González, Alkaloid and essential oil concentration in different populations of peumus boldus. Acta Horticulturae, 676, 181–184 (2005).
   Google Scholar
• P.W. Pare, J. Zajicek, V.L. Ferracini and I.S. Melo, Antifungal terpenoids from Chenopodium ambrosioides. Biochemical Systematics and Ecology, 21(6), 649–653 (1993).
   Web of Science ®Google Scholar
• M.V. Sobral, A.L. Xavier, T.C. Lima and D.P. de Sousa, Antitumor activity of monoterpenes found in essential oils. The Scientific World Journal, article ID 953451, 35 (2014).
   Google Scholar
• A. Gadano, A. Gurni, P. Lopez, G. Ferraro and M. Carbello, In vitro genotoxic evaluation of the medicinal plant Chenopodium ambrosioides. Journal of Ethnopharmacology, 81(1), 11–16 (2002).
   PubMed Web of Science ®Google Scholar
• F. Piscaglia, S. Leoni, A. Venturi, F. Graziella, G. Donati and L. Bolondi, Caution in the use of boldo in herbal laxatives: a case of hepatotoxicity. Scandinavian Journal of Gastroenterology, 40, 236–239 (2005).
   PubMed Web of Science ®Google Scholar
• R.S. Rimada, R. Jeandupeux and F.R. Cafferata Lazaro, Thermal stability of ascaridole in aqueous solution. Its relevance in the pharmacological action. Latin American Journal of Pharmacy, 26, 115–118 (2007).
   Web of Science ®Google Scholar
• D.J. Boland, J.J. Brophy and A.P.N. House, Eucalyptus Leaf Oils: Use, Chemistry, Distillation and Marketing. Inkata Press, Melbourne, Australia, 252 (1991).
   Google Scholar
• J. Franco, T. Nashima and C. Boller, Composição química e atividade antimicrobiana in vitro do óleo essencial de Eucalyptus cinerea F. Mull. ex Benth., Myrtaceae, extraído em diferentes intervalos de tempo. Chemical composition and antimicrobial in vitro activity of the essential oil Eucalyptus cinerea F. Mull. ex Benth., Myrtaceae, extracted in different time intervals. Revista Brasileira de Farmacognosia, 15(3), 191–194 (2005).
   Google Scholar
• A.A. Estanislau, F.A.S. Barros, A.P. Penha, S.C. Santos, P.H. Ferri and J.R. Paula, Composição química e atividade antibacteriana dos óleos essenciais de cinco espécies de Eucalyptus cultivadas em Goiás. Chemical composition and antibacterial activity of the essential oils of five species of Eucalyptus grown in Goiás. Revista Brasileira de Farmacognosia, 11(2), 95–100 (2001).
   Google Scholar
• U. Juergens, T. Engelen, K. Racké, M. Stöber, A. Gillissen and H. Vetter, Inhibitory activity of 1,8-cineol (eucalyptol) on cytokine production in cultured human lymphocytes and monocytes. Pulmonary Pharmacology and Therapeutics, 17(5), 281–287 (2004).
   PubMed Web of Science ®Google Scholar
• F.A. Santos and V.S. Rao, Antiinflammatory and antinociceptive effects of 1,8-cineole, a terpenoid oxide present in many plant essential oils. Phytotherapy Research, 14(4), 240–244 (2000).
   PubMed Web of Science ®Google Scholar
• F.A. Santos and V.S.N. Rao, 1,8-Cineol, a food flavoring agent, prevents ethanol-induced gastric injury in rats. Digestive Diseases and Sciences, 46(2), 331–337 (2001).
   PubMed Web of Science ®Google Scholar
• M. Negahban, S. Moharramipour and F. Sefikdon, Fumigant toxicity of essential oil from Artemisia sieberi Besser against three stored-products insects. Journal of Stored Products Research, 43(2), 123–128 (2007).
   Web of Science ®Google Scholar
• M. Bittner, M.E. Casanueva, C.C. Arbert, M.A. Aguilera, V.J. Hernández and J.V. Becerra, Effects of essential oils from five plant species against the granary weevils Sitophilus zeamais and Acanthoscelides obtectus (Coleoptera. Journal of the Chilean Chemical Society, 53(1), 1455–1459 (2008).
   Web of Science ®Google Scholar
• J.A. Klocke, M.V. Darlington and M.F. Balandrin, 1,8-Cineole (eucalyptol), a mosquito feeding and ovipositional repellent from volatile oil of hemizonia fitchii (asteraceae). Journal of Chemical Ecology, 13(12), 2131–2141 (1987).
   PubMed Web of Science ®Google Scholar
• Internet: material Safety Data Sheet – cineole MSDS. Downloaded from http://www.sciencelab.com/msds.php?msdsId=9924005 ( 24 December 2017).
   Google Scholar
• G. Kiskó and S. Roller, Carvacrol and p-cymene inactivate Escherichia coli O157:H7 in apple juice. BMC Microbiology, 5(36), 1–9 (2005).
   PubMed Web of Science ®Google Scholar
• L.M.L. Campêlo, A.A.C. Almeida, R.L.M. Freitas, G.F. Souza, G.B. Saldanha, C.M. Feitosa and R.M. Freitas, Antioxidant and antinociceptive effects of Citrus limon essential oil in mice. Journal of Biomedicine and Biotechnology, 2011, 1–8 (2011a).
   Google Scholar
• L.M.L. Campêlo, C.G. Sá, A.A.C. Almeida, J.P. Costa, T.H.C. Marques, C.M. Feitosa, G.B. Saldanha and R.M. Freitas, Sedative, anxiolytic and antidepressant activities of Citrus limon (Burn) essential oil in mice. Pharmazie, 66(8), 1–5 (2011b).
   Web of Science ®Google Scholar
• K.K. Aggarwal, Ł.S.P.S. Khanuja, S. Ateeque Ahmad Kumar, T.R.K. Gupta Vivek and S. Kumar, Antimicrobial activity profiles of the two enantiomers of limonene and carvone isolated from the oils of Mentha spicata and Anethum sowa. Flavour and Fragrance Journal, 17, 59–63 (2002).
   Web of Science ®Google Scholar
• C.G. Sá, K.M.F. Cardoso, R.M. Freitas and C.M. Feitosa, Efeito do tratamento agudo com óleo essencial de Citrus sinensis (L) Osbeck na aquisição da memória espacial de ratos avaliada no labirinto aquático de Morris. Effect of the acute treatment with the essential oil of Citrus sinensis (L) Osbeck on the acquisition of spatial memory of rats evaluated in the aquatic labyrinth of Morris. Revista de Ciências Farmacêuticas Básica e Aplicada, 33(2), 211–215 (2012).
   Google Scholar
• A. Astani and P. Schnitzler, Antiviral activity of monoterpenes beta-pinene and limonene against herpes simplex virus in vitro. Iranian Journal of Microbiology, 6(3), 149–155 (2014).
   PubMedGoogle Scholar
• L.L. Karr and J.R. Coats, Insecticidal properties of d-limonene. Journal of Pesticide Science, 13(2), 287–290 (1988).
   Web of Science ®Google Scholar
• H.T. Prates, J.P. Santos, J.M. Waquil, J.D. Fabris, A.B. Oliveira and J.E. Foster, Insecticidal activity of monoterpenes against Rhyzopertha dominica (Fabricius) and Tribolium castaneum (Herbst. Journal of Stored Products Research, 23(4), 243–249 (1998).
   Web of Science ®Google Scholar
• J. Sun, d-Limonene: safety and clinical applications. Alternative Medicine Review, 12(3), 259–264 (2007).
   PubMed Web of Science ®Google Scholar
• H.M. Park, J.H. Lee, J. Yaoyao, H.J. Jun and S.J. Lee, Limonene, a natural cyclic terpene, is an agonistic ligand for adenosine A2A receptors. Biochemical and Biophysical Research Communications, 404(1), 345–348 (2011).
   PubMed Web of Science ®Google Scholar
• S. Jomaa, A. Rahmo, A.S. Alnori and M.E. Chatty, The cytotoxic effect of essential oil of Syrian citrus limon peel on human colorectal carcinoma cell Line (Lim1863). Middle East Journal of Cancer, 3(1), 15–21 (2012).
   Google Scholar
• C.W. Jameson, Toxicology and Carcinogenesis Studies of d-Limonene (CAS No. 5989-27-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies). USA: National Toxicology Program Technical Report Series, 347, 1–165 (1990).
   PubMedGoogle Scholar
• H. Tsuda, Y. Ohshima, H. Nomoto, K.-I. Fujita, E. Matsuda, M. Iigo, N. Takasuka and M.A. Moore, Cancer prevention by natural compounds. Drug Metabolism and Pharmacokinetics, 19(4), 245–263 (2004).
   PubMedGoogle Scholar
• H.J.D. Dorman and S.G. Deans, Antimicrobial agents from plants: antibacterial activity of plant volatile oils. Journal of Applied Microbiology, 88, 308–316 (2000).
   PubMed Web of Science ®Google Scholar
• A.M. Leite, E.O. Lima, E.L. Souza, M.F.F.M. Diniz, V.N. Trajano and I.A. Medeiros, Inhibitory effect of β-pinene, α-pinene and eugenol on the growth of potential infectious endocarditis causing Gram-positive bacteria. Revista Brasileira de Ciências Farmacêuticas, 43(1), 121–126 (2007).
   Google Scholar
• D. Stojkovic, M. Sokovic, J. Glamoclija, A. Dzamic, M. Ristic, A. Fahal, S. Khalid, I. Djuic and S. Petrovic, Susceptibility of three clinical isolates of Actinomodura madurae to α-pinene, the bioactive agent of Pinus pinaster turpentine oil. Archives of Biological Sciences, 60(4), 697–701 (2008).
   Web of Science ®Google Scholar
• A.H. Fahal, Mycetoma thorn on the flesh. Transactions of the Royal Society of Tropical Medicine and Hygiene, 98, 3–11 (2004).
   PubMed Web of Science ®Google Scholar
• A.C.S. Chagas, W.M. Passos, H.T. Prates, R.C. Leite, J. Furlong and I.C.P. Fortes, Efeito acaricida de óleos essenciais e concentrados emulsionáveis de Eucalyptus spp em Boophilus microplus. Acaricide effect of Eucalyptus spp essential oils and concentrated emulsion on Boophilus microplus. Brazilian Journal of Veterinary Research and Animal Science, 39(5), 247–253 (2002).
   Google Scholar
• R. Vila, A.I. Santana, R. Pérez-Rosés, A. Valderrama, M.V. Castelli, S. Mendonça, S. Zacchino, M.P. Gupta and S. Cañigueral, Composition and biological activity of the essential oil from leaves of Plinia cerrocampanensis, a new source of α-bisabolol. Bioresource Technology, 101, 2510–2514 (2010).
   PubMed Web of Science ®Google Scholar
• A.F. Blank, E.M. de Souza, M.F.A. Blank, J.W.A. de Paula and P.B. Alves, Maria Bonita: cultivar de manjericão tipo linalol. Maria Bonita: a linalool type basil cultivar. Pesquisa Agropecuária Brasileira, 42(12), 1811–1813 (2007).
   Web of Science ®Google Scholar
• S. Sibanda, G. Chigwada, M. Poole, E.T. Gwebu, J.A. Noletto, J.M. Schimidt, A.I. Rea and W.N. Satzer, Composition and bioactivity of the leaf essential oil of Heteropyxis dehniae from Zimbabwe. Journal of Ethnopharmacology, 92, 107–111 (2004).
   PubMed Web of Science ®Google Scholar
• S. Cosentino, C.I.G. Tuberoso, B. Pisano, M. Satta, V. Mascia, E. Arzedi and F. Palmas, In vitro antimicrobial activity and chemical composition of Sardinian thymus essential oils. Letters in Applied Microbiology, 29, 130–135 (1999).
   PubMed Web of Science ®Google Scholar
• L. Quintans-Júnior, J.C.F. Moreira, M.A.B. Pasquali, S.M.S. Rabie, A.S. Pires, R. Schröder, T.K. Rabelo, J.P.A. Santos, P.S.S. Lima, S.C.H. Cavalcanti, A.A.S. Araújo, J.S.S. Quintans and D.P. Gelain, Antinociceptive activity and redox profile of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in experimental models. ISRN Toxicology, 2013, 1–11 (2013).
   Google Scholar
• H. Safayhi, J. Sabieraj, E.R. Sailer and H.P. Ammon, Chamazulene: an antioxidant type inhibitor of leukotriene B4 formation. Planta Medica, 60, 410–413 (1994).
   PubMed Web of Science ®Google Scholar
• I.E. Abi-Zaid, L.G. Riachi, C.A.B. De Maria and R.F.A. Moreira, Investigation of the volatile fraction of chamomile (Matricaria recutita L.) infusions prepared from Brazilian commercial sachets. International Food Research Journal, 22(5), 2133–2140 (2015).
   Web of Science ®Google Scholar
• S. Boonbumrung, H. Tamura, J. Mookdasanit, H. Nakamoto, M. Ishihara, T. Yoshizawa and W. Varanyanond, Characteristic aroma components of the volatile oil of yellow keaw mango fruits determined by limited odor unit method. Food Science and Technology Research, 7(3), 200–206 (2001).
   Google Scholar
• M.C. Araújo, M.C.O. Pinheiro, I.E.A. Teixeira, L.G. Riachi, C.B. Rocha, C.A.B. De Maria and R.F.A. Moreira, Volatile and semi-volatile composition of the ripe Brazilian couroupita guianensis fruit. The Natural Products Journal, 4(4), 280–289 (2014).
   Google Scholar
• S.M. Morais, F.E.A. Cantunda-Junior, A.R.A. Silva and N.J.S. Martins, Atividade antioxidante de óleos essenciais de espécies de Croton do nordeste do Brasil. Antioxidant activity of essential oils from Northeastern Brazilian Croton species. Química Nova, 29, 907–910 (2006).
   Web of Science ®Google Scholar
• J.A.M. Paula, J.R. Paula, M.T.F. Bara, M.H. Rezende and H.D. Ferreira, Estudo farmacognóstico das folhas de Pimenta pseudocaryophyllus (Gomes) L.R. Landrum –myrtaceae. Pharmacognostic study about Pimenta pseudocaryophyllus (Gomes) L. R. Landrum leaves – myrtaceae. Revista Brasileira de Farmacognosia, 18, 265–278 (2008).
   Google Scholar
• A.B. Sell and E.A. Carlini, Anesthetic action of methyleugenol and other eugenol derivatives. Pharmacology, 14(4), 367–377 (1976).
   PubMed Web of Science ®Google Scholar
• C.C. Lima, D.N. Criddle, A.N. Coelho-de-Souza, F.J.Q. Monte, M. Jaffar and J.H. Leal-Cardoso, Relaxant and antispasmodic actions of methyleugenol on guinea-pig isolated ileum. Planta Medica, 66(5), 408–411 (2000).
   PubMed Web of Science ®Google Scholar
• M. Sayyah, J. Valizadeh and M. Kamalinejad, Anticonvulsant activity of the leaf essential oil of Laurus nobilis against pentylenetetrazole and maximal electroshock induced seizures. Phytomedicine, 9(3), 212–216 (2002).
   PubMed Web of Science ®Google Scholar
• National Toxicology Program (NTP) 2000. Toxicology and carcinogenesis studies of methyleugenol (CAS No. 93–15–12) in F344/N rats and B6C3F1 mice (gavage studies). USA, DRAFT NTP-TR-491, NIH Publication vol. n°. 98–3950, 412 p. PMID: 12563349.
   Google Scholar
• J.A. Miller, A. Thompson, I.A. Hakim, H.H.S. Chow and C.A. Thomson, d-Limonene: a bioactive food component from citrus and evidence for a potential role in breast cancer prevention and treatment. Oncology Reviews, 5, 31–42 (2010).
   Google Scholar
• M.C. Lanhers, M. Joyeux, R. Soulimani, J. Fleurentin, M. Sayag, F. Mortier, C. Younos and J.M. Pelt, Hepatoprotective and anti-inflammatory effects of a traditional medicinal plant of Chile, Peumus boldus. Planta Medica, 57(2), 110–115 (1991).
   PubMed Web of Science ®Google Scholar
• M.C. Lanhers, J. Fleurentin, A. Rolland and A. Vinche, Activité anti-inflammatoire d’un extrait de Peumus boldus. Phytotherapy, 38–39, 12–13 (1992).
   Google Scholar
• C.V. Klimaczewski, R.A. Saraiva, D.H. Roosa, A. Boligonb, M.L. Athaydeb, J.P. Kamdema, N.V. Barbosa and J.B.T. Rocha, Antioxidant activity of Peumus boldus extract and alkaloid boldine against damage induced by Fe(II)–citrate in rat liver mitochondria in vitro. Industrial Crops and Products, 54, 240–247 (2014).
   Web of Science ®Google Scholar
• N. Backhouse, C. Delporte, M. Givernau, B.K. Cassels, A. Valenzuela and H. Speisky, Anti-inflammatory and antipyretic effects of boldine. Agents and Actions, 42(3–4), 114–117 (1994).
   PubMedGoogle Scholar
• EMA, Assessment report on peumus boldus molina, folium. (European Medicines Agency) Committee on Herbal Medicinal Products. EMA/HMPC/453726/2016, London (2017).
   Google Scholar
• M.J. Magistretti, Remarks on the pharmacological examination of plant extracts. Fitoterapia, 51, 67–79 (1980).
   Google Scholar
• H. Speisky, J.A. Squella and L.J. Núñez-Vergara, Activity of boldine on rat ileum. Planta Medica, 57, 519–522 (1991).
   PubMed Web of Science ®Google Scholar