Advanced search
Publication Cover
Phosphorus, Sulfur, and Silicon and the Related Elements Volume 197, 2022 - Issue 5-6: ICPC-23: 23rd International Conference on Phosphorus Chemistry; Guest Editors:Professor Jozef Drabowicz; Professor Piotr Kiełbasiński and Professor Tomasz Cierpiał
Submit an article Journal homepage
100
Views
0
CrossRef citations to date
0
Altmetric
Short Communication

The synthesis of hydroxymethylenebisphosphonic- (dronic-) and acyl-ethoxycarbonyl-methylphosphonate derivatives

György KeglevichDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, HungaryCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-5366-472XView further author information
ORCID Icon,
Zsuzsanna SzalaiDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, HungaryView further author information
,
Kinga V. GulyásDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, HungaryView further author information
,
Róbert ZahárDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, HungaryView further author information
,
Alajos GrünDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, HungaryORCID Iconhttps://orcid.org/0000-0001-8710-7326View further author information
ORCID Icon &
Csilla Sepsey FürDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest, HungaryORCID Iconhttps://orcid.org/0000-0003-3356-1616View further author information
ORCID Icon
Pages 520-522 | Received 24 Sep 2021, Accepted 23 Oct 2021, Published online: 08 Dec 2021

References

  • Hudson, H. R.; Wardle, N. J.; Bligh, S. W. A.; Greiner, I.; Grün, A.; Keglevich, G. N. N-Heterocyclic Dronic Acids: Applications and Synthesis. Mini Rev. Med. Chem. 2012, 12, 313–325. DOI: 10.2174/138955712799829285.
  • Nagy, D. I.; Grün, A.; Greiner, I.; Keglevich, G. The Role of Phosphorus Trichloride and Phoshorous Acid in the Formation of α-Hydroxymethylenebisphosphonic Acids from the Corresponding Carboxylic Acids – A Mechanistic Overview. Curr. Org. Chem. 2017, 21, 1567–1578. DOI: 10.2174/1385272821666170417122441.
  • Nagy, D. I.; Grün, A.; Garadnay, S.; Greiner, I.; Keglevich, G. Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents. Molecules. 2016, 21, 1046. DOI: 10.3390/molecules21081046.
  • Keglevich, G.; Grün, A.; Aradi, K.; Garadnay, S.; Greiner, I. Optimized Synthesis of N-Heterocyclic Dronic Acids; Closing a Black-Box Era. Tetrahedron Lett. 2011, 52, 2744–2746. DOI: 10.1016/j.tetlet.2011.03.093.
  • Nagy, D. I.; Grün, A.; Lévay, K.; Garadnay, S.; Greiner, I.; Keglevich, G. Efficient Syntheses of Zoledronic Acid as an Active Ingredient of a Drug against Osteoporosis. Synth. Commun. 2018, 48, 663–671. DOI: 10.1080/00397911.2017.1410894.
  • Grün, A.; Szalai, Z.; Keglevich, G. "Greener” Synthesis of Zoledronic Acid from Imidazol-1-yl-Acetic Acid and P-Reagents Using Diethyl Carbonate as the Solvent Component. LOC. 2021, 18, 8–12. DOI: 10.2174/1570178617999200730203738.
  • Rádai, Z.; Kiss, N. Z.; Keglevich, G. An Overview of the Applications of Ionic Liquids as Catalysts and Additives in Organic Chemical Reactions. COC. 2018, 22, 533–556. DOI: 10.2174/1385272822666171227152013.
  • Grün, A.; Bálint, E.; Keglevich, G. Solid–Liquid Phase C-Alkylation of Active Methylene Containing Compounds under Microwave Conditions. Catalysts. 2015, 5, 634–652. DOI: 10.3390/catal5020634.
  • Sum, F.-W.; Weiler, L. Stereoselective Synthesis of β-Substituted α,β-Unsaturated Esters by Dialkylcuprate Coupling to the Enol Phosphate of β-Keto Esters. Can. J. Chem. 1979, 57, 1431–1441. DOI: 10.1139/v79-234.
  • Gulyás, K. V.; Keglevich, G. The Surprising Diacylation of Diethyl (Ethoxycarbonylmethyl)Phosphonate. Mendeleev Commun. 2021, 31, 244–245. DOI: 10.1016/j.mencom.2021.03.033.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.