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Research Article

IL-4 Biology: Impact on Normal and Leukemic CLL B Cells

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Pages 897-903 | Published online: 01 Jul 2009

  • Dameshek, W. (1967) "Chronic lymphocytic leukemia--an accumulative disease of immunolgically incompetent lymphocytes", Blood 29(Suppl), 566-584.
  • Collins, R.J., Verschuer, L.A., Harmon, B.V., Prentice, R.L., Pope, J.H. and Kerr, J.F. (1989) "Spontaneous programmed death (apoptosis) of B-chronic lymphocytic leukaemia cells following their culture in vitro", Br. J. Haematol. 71, 343-350.
  • Dighiero, G., Travade, P., Chevret, S., Fenaux, P., Chastang, C. and Binet, J.L. (1991) "B-cell chronic lymphocytic leukemia: present status and future directions. French Cooperative Group on CLL", Blood, 1901-1914.
  • Mainou-Fowler, T., Copplestone, J. and Prentice, A. (1995) "Effect of interleukins on the proliferation and survivol of B cell chronic lymphocytic leukaemia cells", J. Clin. Pathol. 48, 482-487.
  • Jewell, A.P., Worman, C.P., Lydyard, P.M., Yong, K.L., Giles, F.J. and Goldstone, A.H. (1994) "Interferon-alpha up-regulates bcl-2 expression and protects B-CLL cells from apoptosis in vitro and in vivo", Br. J. Haematol. 88, 268-274.
  • Chaouchi, N., Wallon, C., Taieb, J., Auffredou, M.T., Tertian, G., Lemoine, F.M., Delfraissy, J.F. and Vazquez, A. (1994) "Interferon-alpha-mediated prevention of in vitro apoptosis of chronic lymphocytic leukemia B cells: role of bcl-2 and c-myc", Clin. Immunol. Immunopathol. 73, 197-204.
  • Buschle, M., Campana, D., Carding, S.R., Richard, C., Hoffbrand, A.V. and Brenner, M.K. (1993) "Interferon gamma inhibits apoptotic cell death in B cell chronic lymphocytic leukemia", J. Exp. Med. 177, 213-218.
  • Huang, R.W., Tsuda, H. and Takatsuki, K. (1993) "Interleukin-2 prevents programmed cell death in chronic lymphocytic leukemia cells", Int. J. Hematol. 58, 83-92.
  • Dancescu, M., Rubio-Trujillo, M., Biron, G., Bron, D., Delespesse, G. and Sarfati, M. (1992) "Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression", J. Exp. Med. 176, 1319-1326.
  • Mu, X., Kay, N.E., Gosland, M.P. and Jennings, C.D. (1997) "Analysis of blood T-cell cytokine expression in B-chronic lymphocytic leukaemia: evidence for increased levels of cytoplasmic IL-4 in resting and activated CD8 T cells", Br. J. Haematol. 96, 733-735.
  • de Totero, D., Reato, G., Mauro, F., Cignetti, A., Ferrini, S., Guarini, A., Gobbi, M., Grossi, C.E. and Foa, R. (1999) "IL4 production and increased CD30 expression by a unique CD8+ T-cell subset in B-cell chronic lymphocytic leukemia", Br. J. Haematol. 104, 589-599.
  • Mainou-Fowler, T., Proctor, S.J., Miller, S. and Dickinson, A.M. (2001) "Expression and production of interleukin 4 in B-cell chronic lymphocytic leukaemia", Leuk. Lymphoma 42, 689-698.
  • Kay, N.E., Han, L., Bone, N. and Williams, G. (2001) "Interleukin 4 content in chronic lymphocytic leukaemia (CLL) B cells and blood CD8+ T cells from B-CLL patients: impact on clonal B-cell apoptosis", Br. J. Haematol. 112, 760-767.
  • Seder, R.A., Paul, W.E., Davis, M.M. and Fazekas de St Groth, B. (1992) "The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice", J. Exp. Med. 176, 1091-1098.
  • Weiss, D.L. and Brown, M.A. (2001) "Regulation of IL-4 production in mast cells: a paradigm for cell-type-specific gene expression", Immunol. Rev. 179, 35-47.
  • Rao, A., Luo, C. and Hogan, P.G. (1997) "Transcription factors of the NFAT family: regulation and function", Annu. Rev. Immunol. 15, 707-747.
  • Kaplan, M.H., Schindler, U., Smiley, S.T. and Grusby, M.J. (1996) "Stat6 is required for mediating responses to IL-4 and for development of Th2 cells", Immunity 4, 313-319.
  • Ranganath, S., Ouyang, W., Bhattarcharya, D., Sha, W.C., Grupe, A., Peltz, G. and Murphy, K.M. (1998) "GATA-3-dependent enhancer activity in IL-4 gene regulation", J. Immunol. 161, 3822-3826.
  • Kim, J.I., Ho, I.C., Grusby, M.J. and Glimcher, L.H. (1999) "The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines", Immunity 10, 745-751.
  • Debinski, W., Minter, R., Leland, P., Obiri, N.I. and Puri, R.K. (1996) "Receptor for interleukin (IL) 13 does not interact with IL4 but receptor for IL4 interacts with IL13 on human glioma cells", J. Biol. Chem. 271, 22428-22433.
  • Kawakami, K., Kawakami, M. and Puri, R.K. (2001) "Over-expressed cell surface interleukin-4 receptor molecules can be successfully targeted for antitumor cytotoxin therapy", Crit. Rev. Immunol 21, 299-310.
  • Kay, N.E., Bone, N.D., Jelinek, D.F., Leland, P., Frank, D.A., Battle, T.E. and Puri, R.K. (2002) Plasma Membrane IL-4 Receptors Can be Targeted to Eliminate B-Chronic Lymphocytic Leukemia B Cells (Abstract 2324) (American Society of Hematology, Philadelphia, PA).
  • Nelms, K., Keegan, A.D., Zamorano, J., Ryan, J.J. and Paul, W.E. (1999) "The IL-4 receptor: signaling mechanisms and biologic functions", Annu. Rev. Immunol. 17, 701- 738.
  • Izuhara, K., Feldman, R.A., Greer, P. and Harada, N. (1994) "Interaction of the c-fes proto-oncogene product with the interleukin-4 receptor", J. Biol. Chem. 269, 18623-18629.
  • Wang, L.M., Myers, Jr., M.G., Sun, X.J., Aaronson, S.A., White, M. and Pierce, J.H. (1993) "IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells", Science 261, 1591-1594.
  • Sun, X.J., Wang, L.M., Zhang, Y., Yenush, L., Myers, Jr., M.G., Glasheen, E., Lane, W.S., Pierce, J.H. and White, M.F. (1995) "Role of IRS-2 in insulin and cytokine signalling", Nature 377, 173-177.
  • Patel, B.K., Pierce, J.H. and LaRochelle, W.J. (1998) "Regulation of interleukin 4-mediated signaling by naturally occurring dominant negative and attenuated forms of human Stat6", Proc. Natl Acad. Sci. USA 95, 172-177.
  • Ryan, J.J., McReynolds, L.J., Keegan, A., Wang, L.H., Garfein, E., Rothman, P., Nelms, K. and Paul, W.E. (1996) "Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor", Immunity 4, 123-132.
  • Noellae, R., Krammer, P.H., Ohara, J., Uhr, J.W. and Vitetta, E.S. (1984) "Increased expression of la antigens on resting B cells: an additional role for B-cell growth factor", Proc. Natl Acad. Sci. USA 81, 6149-6153.
  • Vitetta, E.S., Ohara, J., Myers, C.D., Layton, J.E., Krammer, P.H. and Paul, W.E. (1985) "Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgGI", J. Exp. Med. 162, 1726-1731.
  • Defrance, T., Vanbervliet, B., Aubry, J.P., Takebe, Y., Arai, N., Miyajima, A., Yokote, T., Lee, F., Arai, K. and de Vries, J.E. (1987) "B cell growth-promoting activity of recombinant human interleukin 4", J. Immunol. 139, 1135-1141.
  • Clark, E.A., Shu, G.L., Luscher, B., Draves, K.E., Banchereau, J., Ledbetter, J.A. and Valentine, M.A. (1989) "Activation of human B cells. Comparison of the signal transduced by IL-4 to four different competence signals", J. Immunol. 143, 3873-3880.
  • Jelinek, D.F. and Lipsky, P.E. (1988) "Inhibitory influence of IL-4 on human B cell responsiveness", J. Immunol. 141, 164-173.
  • Illera, V.A., Perandones, C.E., Stunz, L.L., Mower, Jr. D.A. and Ashman, R.F. (1993) "Apoptosis in splenic B lymphocytes. Regulation by protein kinase C and IL-4", J. Immunol. 151, 2965-2973.
  • Parry, S.L., Hasbold, J., Holman, M. and Klaus, G.G. (1994) "Hypercross-linking surface IgM or IgD receptors on mature B cells induces apoptosis that is reversed by costimulation with IL-4 and anti-CD40", J. Immunol. 152, 2821-2829.
  • Minshall, C., Arkins, S., Freund, G.G. and Kelley, K.W. (1996) "Requirement for phosphatidylinositol 3'-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survivol factor", J. Immunol. 156, 939-947.
  • Minshall, C., Arkins, S., Straza, J., Conners, J., Dantzer, R., Freund, G.G. and Kelley, K.W. (1997) "IL-4 and insulin-like growth factor-1 inhibit the decline in Bcl-2 and promote the survivol of IL-3-deprived myeloid progenitors", J. Immunol. 159, 1225-1232.
  • Aronica, M.A., Goenka, S. and Boothby, M. (2000) "IL-4-dependent induction of BCL-2 and BCL-X1 in activated T lymphocytes through a STAT6- and PI 3-kinase-independent pathway", Cytokine 12, 578-587.
  • Minshall, C., Arkins, S., Dantzer, R., Freund, G.G. and Kelley, K.W. (1999) "Phosphatidylinositol 3'-kinase, but not S6-kinase, is required for insulin-like growth factor-I and IL-4 to maintain expression of Bcl-2 and promote survival of myeloid progenitors", J. Immunol. 162, 4542-4549.
  • Panayiotidis, P., Ganeshaguru, K., Jabbar, S.A. and Hoftbrand, A.V. (1993) "Interleokin-4 inhibits apoptotic cell death and loss of the bcl-2 protein in B-chronic lymphocytic leukaemia cells in vitro", Br. J. Haematol. 85, 439-445.
  • Bernal, A., Pastore, R.D., Asgary, Z., Keller, S.A., Cesarman, E., Liou, H.C. and Schattner, E.J. (2001) "Survival of leukemic B cells promoted by engagement of the antigen receptor", Blood 98, 3050-3057.
  • Siegel, R.M., Chan, F.K., Chun, H.J. and Lenardo, M.J. (2000) "The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity", Nat. Immunol. 1, 469-474.
  • Foote, L.C., Howard, R.G., Marshak-Rothstein, A. and Rothstein, T.L. (1996) "IL-4 induces Fas resistance in B cells", J. Immunol. 157, 2749-2753.
  • Williams, J.F., Petrus, M.J., Wright, J.A., Husebekk, A., Fellowes, V., Read, E.J., Gress, R.E. and Fowler, D.H. (1999) "Fas-mediated lysis of chronic lymphocytic leukaemia cells: role of type 1 versus type II cytokines and autologous fasL-expressing T cells", Br. J. Haematol. 107, 99-105.
  • Mainou-Fowler, T., Miller, S., Proctor, S.J. and Dickinson, A.M. (2001) "The levels of TNFA, IL-4 and IL-10 production by T cells in B-cell chronic lymphocytic leukemia (B-CLL)", Leuk. Res. 25, 157-163
  • Gajewski, T.F., Pinnas, M., Wong, T. and Fitch, F.W. (1991) "Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations", J. Immunol. 146, 1750-1758
  • Douglas, R.S., Capocasale, R.J., Lamb, R.J., Nowell, P.C. and Moore, J.S. (1997) "Chronic lymphocytic leukemia B cells are resistant to the apoptotic effects of transforming growth factor-beta", Blood 89, 941-947.
  • Nakanishi, K., Matsui, K., Kashiwamura, S., Nishioka, Y., Nomura, J., Nishimura, Y., Sakaguchi, N., Yonehara, S., Higashino, K. and Shinka, S. (1996) "IL-4 and anti-CD40 protect against Fas-mediated B cell apoptosis and induce B cell growth and differentiation", Int. Immunol. 8, 791-798.
  • Barragan, M., Bellosillo, B., Campas, C., Colomer, D., Pons, G. and Oil, J. (2002) "Involvement of protein kinase C and phosphatidyl-inositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells", Blood 99, 2969-2976.
  • Luodin, J., Kimby, E., Bergmann, L., Karakas, T., Mellstedt, H. and Osterborg, A. (2001) "Interleukin 4 therapy for patients with chronic lymphocytic leukaemia: a phase I/II study", Br. J. Haematal. 112, 155-160.
  • Chaouchi, N., Wallon, C., Goujard, C., Tertian, G., Rudent, A., Caput, D., Ferrera, P., Minty, A., Vazquez, A. and Delfraissy, J.F. (1996) "Interteukin-13 inhibits interleukin-2-induced proliferation and protects chronic lymphocytic leukemia B cells from in vitro apoptosis", Blood 87, 1022-1029.
  • Henderson, Jr., W.R., Chi, E.Y. and Maliszewski, C.R. (2000) "Soluble IL-4 receptor inhibits airway inflammation following allergen challenge in a mouse model of asthma", J. Immunol. 164, 1086-1095.
  • Kawakami, K., Kawakami, M., Husain, S.R. and Puri, R.K. (2002) 'Targeting interleukin-4 receptors for effective pancreatic cancer therapy", Cancer Res. 62, 3575-3580.
  • Joshi, B.H., Leland, P., Silber, J., Kreitman, R.J., Pastan, I., Berger, M. and Puri, R.K. (2002) "IL-4 receptors on human medullo-blastoma tumours serve as a sensitive target for a circular permuted IL-4-Pseudomonas exotoxin fusion protein", Br. J. Cancer 86, 285-291.

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