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Leukemia & Lymphoma Volume 58, 2017 - Issue 1
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Letters to the Editor

Ability to downregulate the level of cyclin-dependent kinase inhibitor p27Kip1 after DNA damage is retained in chronic lymphocytic leukemia cells with functional ATM/p53 signaling pathway

Leona Raskova KafkovaDepartment of Biology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic; Correspondence[email protected]
,
Veronika NavrkalovaCenter of Molecular Medicine, CEITEC – Central European Institute of Technology, Masaryk University, Brno, Czech Republic;
,
Marie JarosovaDepartment of Hemato-Oncology, Faculty of Medicine and Dentistry, Palacky University and University Hospital Olomouc, Czech Republic;
,
Tomas LojaCenter of Molecular Medicine, CEITEC – Central European Institute of Technology, Masaryk University, Brno, Czech Republic;
,
Jana ChovancovaCenter of Molecular Medicine, CEITEC – Central European Institute of Technology, Masaryk University, Brno, Czech Republic;
,
Jana KucerovaDepartment of Biology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic;
,
Eva KriegovaDepartment of Immunology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic;
,
Vit ProchazkaDepartment of Hemato-Oncology, Faculty of Medicine and Dentistry, Palacky University and University Hospital Olomouc, Czech Republic;
,
Zdenek NovakDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA
,
Dana SimkovaDepartment of Biology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic;
,
Sarka PospisilovaCenter of Molecular Medicine, CEITEC – Central European Institute of Technology, Masaryk University, Brno, Czech Republic;
&
Vladimir DivokyDepartment of Biology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic; Correspondence[email protected]
 show all
Pages 199-203 | Received 09 Jul 2015, Accepted 01 May 2016, Published online: 07 Jun 2016

References

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  • Skowronska A, Parker A, Ahmed G, et al. Biallelic ATM inactivation significantly reduces survival in patients treated on the United Kingdom leukemia research fund chronic lymphocytic leukemia 4 trial. J Clin Oncol. 2012;30:4524–4532.
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  • Caraballo JM, Acosta JC, Cortes MA, et al. High p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycle. Oncotarget. 2014;5:4694–4708.
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  • Hu H, Du L, Nagabayashi G, et al. ATM is down-regulated by N-Myc-regulated microRNA-421. Proc Natl Acad Sci USA. 2010;107:1506–1511.
  • Mehdipour P, Karami F, Javan F, et al. Linking ATM promoter methylation to cell cycle protein expression in brain tumor patients: cellular molecular triangle correlation in ATM territory. Mol Neurobiol. 2015;52:293–302.
  • Cuadrado M, Gutierrez-Martinez P, Swat A, et al. p27Kip1 stabilization is essential for the maintenance of cell cycle arrest in response to DNA damage. Cancer Res. 2009;69:8726–8732.
  • Iwahori S, Kohmon D, Kobayashi J, et al. ATM regulates Cdt1 stability during the unperturbed S phase to prevent re-replication. Cell Cycle. 2014;13:471–481.

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