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Original Articles: Research

Alterations of the bone marrow stromal microenvironment in adult patients with acute myeloid and lymphoblastic leukemias before and after allogeneic hematopoietic stem cell transplantation

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Pages 408-417 | Received 04 Dec 2015, Accepted 01 May 2016, Published online: 31 May 2016

References

  • Taichman RS. Blood and bone: two tissues whose fates are intertwined to create the hematopoietic stem-cell niche. Blood. 2005;105:2631–2639.
  • Anthony BA, Link DC. Regulation of hematopoietic stem cells by bone marrow stromal cells. Trends Immunol. 2014;35:32–37.
  • Ehninger A, Trumpp A. The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in. J Exp Med. 2011;208:421–428.
  • Caplan AI. Mesenchymal stem cells. J Orthop Res. 1991;9:641–650.
  • Chertkov JL, Gurevitch OA, Udalov GA. Role of bone marrow stroma in hemopoietic stem cell regulation. Exp Hematol. 1980;8:770–778.
  • Horwitz EM, Le Blanc K, Dominici M, et al. Clarification of the nomenclature for MSC: the International Society for Cellular Therapy position statement. Cytotherapy. 2005;7:393–395.
  • Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8:315–317.
  • Méndez-Ferrer S, Michurina TV, Ferraro F, et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature. 2010;466:829–834.
  • Park D, Sykes DB, Scadden DT. The hematopoietic stem cell niche. Front Biosci (Landmark Ed). 2012;17:30–39.
  • Friedenstein AJ, Chailakhjan RK, Lalykina KS. The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet. 1970;3:393–403.
  • Koide Y, Morikawa S, Mabuchi Y, et al. Two distinct stem cell lineages in murine bone marrow. Stem Cells. 2007;25:1213–1221.
  • Castro-Malaspina H, Gay RE, Resnick G, et al. Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny. Blood. 1980;56:289–301.
  • Nifontova I, Svinareva D, Petrova T, et al. Sensitivity of mesenchymal stem cells and their progeny to medicines used for the treatment of hematoproliferative diseases. Acta Haematol. 2008;119:98–103.
  • Kuznetsov SA, Friedenstein AJ, Robey PG. Factors required for bone marrow stromal fibroblast colony formation in vitro. Br J Haematol. 1997;97:561–570.
  • Bradstock KF, Gottlieb DJ. Interaction of acute leukemia cells with the bone marrow microenvironment: implications for control of minimal residual disease. Leuk Lymphoma. 1995;18:1–16.
  • van den Berk LCJ, van der Veer A, Willemse ME, et al. Disturbed CXCR4/CXCL12 axis in paediatric precursor B-cell acute lymphoblastic leukaemia. Br J Haematol. 2014;166:240–249.
  • Shalapour S, Eckert C, Seeger K, et al. Leukemia-associated genetic aberrations in mesenchymal stem cells of children with acute lymphoblastic leukemia. J Mol Med (Berl). 2010;88:249–265.
  • Menendez P, Catalina P, Rodríguez R, et al. Bone marrow mesenchymal stem cells from infants with MLL-AF4+ acute leukemia harbor and express the MLL-AF4 fusion gene. J Exp Med. 2009;206:3131–3141.
  • Blau O, Baldus CD, Hofmann W-K, et al. Mesenchymal stromal cells of myelodysplastic syndrome and acute myeloid leukemia patients have distinct genetic abnormalities compared with leukemic blasts. Blood. 2011;118:5583–5592.
  • Pontikoglou C, Kastrinaki M-C, Klaus M, et al. Study of the quantitative, functional, cytogenetic, and immunoregulatory properties of bone marrow mesenchymal stem cells in patients with B-cell chronic lymphocytic leukemia. Stem Cells Dev. 2013;22:1329–1341.
  • Vicente López Á, Vázquez García MN, Melen GJ, et al. Mesenchymal stromal cells derived from the bone marrow of acute lymphoblastic leukemia patients show altered BMP4 production: correlations with the course of disease. PLoS One. 2014;9:e84496.
  • Conforti A, Biagini S, Del Bufalo F, et al. Biological, functional and genetic characterization of bone marrow-derived mesenchymal stromal cells from pediatric patients affected by acute lymphoblastic leukemia. PLoS One. 2013;8:e76989.
  • Lisovsky MYa, Savchenko VG. Defect of stromal microenvironment in long term bone marrow cultures of patients with acute and chronic myelogenous leukemias. Leuk Lymphoma. 1995;19:145–152.
  • Campioni D, Bardi MA, Cavazzini F, et al. Cytogenetic and molecular cytogenetic profile of bone marrow-derived mesenchymal stromal cells in chronic and acute lymphoproliferative disorders. Ann Hematol. 2012;91:1563–1577.
  • Galotto M, Berisso G, Delfino L, et al. Stromal damage as consequence of high-dose chemo/radiotherapy in bone marrow transplant recipients. Exp Hematol. 1999;27:1460–1466.
  • Banfi A, Podestà M, Fazzuoli L, et al. High-dose chemotherapy shows a dose-dependent toxicity to bone marrow osteoprogenitors: a mechanism for post-bone marrow transplantation osteopenia. Cancer. 2001;92:2419–2428.
  • Georgiou KR, Scherer MA, King TJ, et al. Deregulation of the CXCL12/CXCR4 axis in methotrexate chemotherapy-induced damage and recovery of the bone marrow microenvironment. Int J Exp Pathol. 2012;93:104–114.
  • Devine SM, Hoffman R. Role of mesenchymal stem cells in hematopoietic stem cell transplantation. Curr Opin Hematol. 2000;7:358–363.
  • Bemark M, Holmqvist J, Abrahamsson J, et al. Translational Mini-Review Series on B cell subsets in disease. Reconstitution after haematopoietic stem cell transplantation – revelation of B cell developmental pathways and lineage phenotypes. Clin Exp Immunol. 2012;167:15–25.
  • Storek J, Geddes M, Khan F, et al. Reconstitution of the immune system after hematopoietic stem cell transplantation in humans. Semin Immunopathol. 2008;30:425–437.
  • Parovichnikova EN, Kliasova GA, Isaev VG, et al. [First results of Ph-negative acute lymphoblastic leukemia therapy of adults according to the protocol of Research Group of Russian Hematological Centers ALL-2009]. Ter Arkh. 2011;83:11–17.
  • Parovichnikova EN, Troitskaia VV, Kliasova GA, et al. [Treating patients with acute myeloid leukemias (AML) according to the protocol of the AML-01.10 Russian multicenter randomized trial: the coordinating center’s results]. Ter Arkh. 2014;86:14–23.
  • Kuzmina LA, Petinati NA, Parovichnikova EN, et al. Multipotent Mesenchymal Stromal Cells for the Prophylaxis of Acute Graft-versus-Host Disease-A Phase II Study. Stem Cells Int. 2012;2012:968213.
  • Petinati NA, Shipunova IN, Bigil’deev AE, et al. [Characteristics of stromal cell precursors in patients after allogeneic bone marrow transplantation]. Ter Arkh. 2013;85:95–99.
  • Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate–phenol–chloroform extraction. Anal Biochem. 1987;162:156–159.
  • Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 2008;3:1101–1108.
  • Lane SW. Bad to the bone. Blood. 2012;119:323–325.
  • Zhao Z-G, Liang Y, Li K, et al. Phenotypic and functional comparison of mesenchymal stem cells derived from the bone marrow of normal adults and patients with hematologic malignant diseases. Stem Cells Dev. 2007;16:637–648.
  • Yin W-J, Yang P-D, Huang Y-Z, et al. [Comparison of biological characteristics of bone marrow mesenchymal stem cells in acute myeloid leukemia with those from non-leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009;17:395–399.
  • Currie GA. Platelet-derived growth-factor requirements for in vitro proliferation of normal and malignant mesenchymal cells. Br J Cancer. 1981;43:335–343.
  • Ng F, Boucher S, Koh S, et al. PDGF, TGF-beta, and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and osteogenic lineages. Blood. 2008;112:295–307.
  • Ball SG, Worthington JJ, Canfield AE, et al. Mesenchymal stromal cells: inhibiting PDGF receptors or depleting fibronectin induces mesodermal progenitors with endothelial potential. Stem Cells. 2014;32:694–705.
  • Ravasi T, Suzuki H, Cannistraci CV, et al. An atlas of combinatorial transcriptional regulation in mouse and man. Cell. 2010;140:744–752.
  • Müller-Tidow C, Schwäble J, Steffen B, et al. High-throughput analysis of genome-wide receptor tyrosine kinase expression in human cancers identifies potential novel drug targets. Clin Cancer Res. 2004;10:1241–1249.
  • Bigildeev AE, Zhironkina OA, Shipounova IN, et al. Clonal composition of human multipotent mesenchymal stromal cells. Exp Hematol. 2012;40:847–856.e4.
  • Fouillard L, Francois S, Bouchet S, et al. Innovative cell therapy in the treatment of serious adverse events related to both chemo-radiotherapy protocol and acute myeloid leukemia syndrome: the infusion of mesenchymal stem cells post-treatment reduces hematopoietic toxicity and promotes hematopoietic reconstitution. Curr Pharm Biotechnol. 2014;14:842–848.
  • Domenech J, Linassier C, Gihana E, et al. Prolonged impairment of hematopoiesis after high-dose therapy followed by autologous bone marrow transplantation. Blood. 1995;85:3320–3327.
  • Domenech J, Roingeard F, Binet C. The mechanisms involved in the impairment of hematopoiesis after autologous bone marrow transplantation. Leuk Lymphoma. 1997;24:239–256.
  • Lin Z, Kong Y, Wang Y, et al. [Analysis of risk factors for secondary cytopenia after allogeneic hematopoietic stem cell transplantation]. Zhonghua Xue Ye Xue Za Zhi. 2014;35:4–8.
  • Gaundar SS, Bradstock KF, Bendall LJ. p38MAPK inhibitors attenuate cytokine production by bone marrow stromal cells and reduce stroma-mediated proliferation of acute lymphoblastic leukemia cells. Cell Cycle. 2014;8:2977–2985.
  • Cogle CR, Goldman DC, Madlambayan GJ, et al. Functional integration of acute myeloid leukemia into the vascular niche. Leukemia. 2014;28:1978–1987.
  • de Bont ESJM, Neefjes VME, Rosati S, et al. New vessel formation and aberrant VEGF/VEGFR signaling in acute leukemia: does it matter? Leuk Lymphoma. 2002;43:1901–1909.

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