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Leukemia & Lymphoma Volume 59, 2018 - Issue 11
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Letter to the Editor

Azacitidine effectively reduces TP53-mutant leukemic cell burden in secondary acute myeloid leukemia after cord blood transplantation

Tomomi TakeiDivision of Molecular Therapy, Advanced Clinical Research Center, the Institute of Medical Science, University of Tokyo, Tokyo, Japan;
,
Kazuaki YokoyamaDepartment of Hematology/Oncology, Research Hospital, the Institute of Medical Science, University of Tokyo, Tokyo, Japan;
,
Eigo ShimizuLaboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan;
,
Takaaki KonumaDepartment of Hematology/Oncology, Research Hospital, the Institute of Medical Science, University of Tokyo, Tokyo, Japan;
,
Satoshi TakahashiDepartment of Hematology/Oncology, Research Hospital, the Institute of Medical Science, University of Tokyo, Tokyo, Japan;
,
Rui YamaguchiLaboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan;
,
Seiya ImotoDivision of Health Medical Data Science, Health Intelligence Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
,
Satoru MiyanoLaboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan;
&
Arinobu TojoDivision of Molecular Therapy, Advanced Clinical Research Center, the Institute of Medical Science, University of Tokyo, Tokyo, Japan; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-9016-1948
ORCID Icon show all
Pages 2755-2756 | Received 03 Jan 2018, Accepted 09 Feb 2018, Published online: 12 Apr 2018

References

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  • Yoshizato T, Nannya Y, Atsuta Y, et al. Genetic abnormalities in myelodysplasia and secondary acute myeloid leukemia: impact on outcome of stem cell transplantation. Blood. 2017;129:2347–2358.
  • Middeke JM, Herold S, Rucker-Braun E, et al. TP53 mutation in patients with high-risk acute myeloid leukaemia treated with allogeneic haematopoietic stem cell transplantation. Br J Haematol. 2016;172:914–922.
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  • Fenaux P, Mufti GJ, Hellstrom-Lindberg E, et al. Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia. JCO. 2010;28:562–569.
  • Field T, Perkins J, Huang Y, et al. 5-Azacitidine for myelodysplasia before allogeneic hematopoietic cell transplantation. Bone Marrow Transplant. 2010;45:255–260.
  • Jabbour E, Giralt S, Kantarjian H, et al. Low-dose azacitidine after allogeneic stem cell transplantation for acute leukemia. Cancer. 2009;115:1899–1905.
  • Goodyear OC, Dennis M, Jilani NY, et al. Azacitidine augments expansion of regulatory T cells after allogeneic stem cell transplantation in patients with acute myeloid leukemia (AML). Blood. 2012;119:3361–3369.
  • Welch JS, Petti AA, Miller CA, et al. TP53 and decitabine in acute myeloid leukemia and myelodysplastic syndromes. N Engl J Med. 2016;375:2023–2036.

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