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Leukemia & Lymphoma Volume 60, 2019 - Issue 9
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Original Article: Clinical

Human herpes virus 6 reactivation following autologous hematopoietic cell transplantation – a single-center experience

Liat Shargian-AlonInstitute of Hematology, Davidoff Cancer Center, Rabin Medical Center, Petah-Tikva, Israel; ;Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-6429-148X
ORCID Icon,
Dafna YahavSackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; ;Infectious Diseases Unit, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, Israel;
,
Uri RozovskiInstitute of Hematology, Davidoff Cancer Center, Rabin Medical Center, Petah-Tikva, Israel; ;Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel;
,
Sara DovratCentral Virology Laboratory, Israel Ministry of Health, Chaim Sheba Medical Center, Tel-Hashomer, Israel
,
Irina AmitaiInstitute of Hematology, Davidoff Cancer Center, Rabin Medical Center, Petah-Tikva, Israel; ;Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel;
,
Michal Sela-NavonInstitute of Hematology, Davidoff Cancer Center, Rabin Medical Center, Petah-Tikva, Israel;
,
Oren PasvolskyInstitute of Hematology, Davidoff Cancer Center, Rabin Medical Center, Petah-Tikva, Israel; ;Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel;
,
Pia RaananiInstitute of Hematology, Davidoff Cancer Center, Rabin Medical Center, Petah-Tikva, Israel; ;Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel;
&
Moshe YeshurunInstitute of Hematology, Davidoff Cancer Center, Rabin Medical Center, Petah-Tikva, Israel; ;Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel;
show all
Pages 2230-2236 | Received 10 Sep 2018, Accepted 22 Jan 2019, Published online: 18 Feb 2019

References

  • Zerr DM, Meier AS, Selke SS, et al. A population-based study of primary human herpesvirus 6 infection. N Engl J Med. 2005;352:768–776.
  • Singh N, Carrigan DR. Human herpesvirus-6 in transplantation: an emerging pathogen. Ann Intern Med. 1996;124:1065–1071.
  • Zerr DM. Human herpesvirus 6 (HHV-6) disease in the setting of transplantation. Curr Opin Infect Dis. 2012;25:438–444.
  • Kadakia MP, Rybka WB, Stewart JA, et al. Human herpesvirus 6: infection and disease following autologous and allogeneic bone marrow transplantation. Blood. 1996;87:5341–5354.
  • Inazawa N, Hori T, Nojima M, et al. Virus reactivations after autologous hematopoietic stem cell transplantation detected by multiplex PCR assay. J Med Virol. 2017;89:358–362.
  • Wilborn F, Brinkmann V, Schmidt CA, et al. Herpesvirus type 6 in patients undergoing bone marrow transplantation: serologic features and detection by polymerase chain reaction. Blood. 1994;83:3052–3058.
  • Imbert-Marcille BM, Tang XW, Lepelletier D, et al. Human herpesvirus 6 infection after autologous or allogeneic stem cell transplantation: a single-center prospective longitudinal study of 92 patients. Clin Infect Dis. 2000;31:881–886.
  • Perissinotti AJ, Gulbis A, Shpall EJ, et al. Characterizing human herpes virus 6 following hematopoietic stem cell transplantation. J Oncol Pharm Pract. 2015;21:85–92.
  • Horowitz N, Oren I, Lavi N, et al. New rising infection: human herpesvirus 6 is frequent in myeloma patients undergoing autologous stem cell transplantation after induction therapy with bortezomib. Bone Marrow Res. 2012;2012:409765.
  • Colombier MA, Amorim S, Salmona M, et al. HHV-6 reactivation as a cause of fever in autologous hematopoietic stem cell transplant recipients. J Infect. 2017;75:155–159.
  • Yeshurun M, Vaxman I, Shargian L, et al. Antibacterial prophylaxis with ciprofloxacin for patients with multiple myeloma and lymphoma undergoing autologous haematopoietic cell transplantation: a quasi-experimental single-centre before-after study. Clin Microbiol Infect. 2018;24:749–754.
  • Tavakoli NP, Nattanmai S, Hull R, et al. Detection and typing of human herpesvirus 6 by molecular methods in specimens from patients diagnosed with encephalitis or meningitis. J Clin Microbiol. 2007;45:3972–3978.
  • Pantry SN, Medveczky PG. Latency, integration, and reactivation of human herpesvirus-6. Viruses. 2017;9:194.
  • Spitzer TR. Engraftment syndrome following hematopoietic stem cell transplantation. Bone Marrow Transplant. 2001;27:893–898.
  • Chapenko S, Trociukas I, Donina S, et al. Relationship between beta-herpesviruses reactivation and development of complications after autologous peripheral blood stem cell transplantation. J Med Virol. 2012;84:1953–1960.
  • Bommer M, Pauls S, Greiner J. Challenging complications of treatment – human herpes virus 6 encephalitis and pneumonitis in a patient undergoing autologous stem cell transplantation for relapsed Hodgkin’s disease: a case report. Virol J. 2009;6:111.
  • De Pagter PJ, Schuurman R, Keukens L, et al. Human herpes virus 6 reactivation: important predictor for poor outcome after myeloablative, but not non-myeloablative allo-SCT. Bone Marrow Transplant. 2013;48:1460–1464.
  • Greco R, Crucitti L, Noviello M, et al. Human herpesvirus 6 infection following haploidentical transplantation: immune recovery and outcome. Biol Blood Marrow Transplant. 2016;22:2250–2255.
  • Dulery R, Salleron J, Dewilde A, et al. Early human herpesvirus type 6 reactivation after allogeneic stem cell transplantation: a large-scale clinical study. Biol Blood Marrow Transplant. 2012;18:1080–1089.
  • Baumer T, Fry C, Luppe S, et al. Human herpes virus-6 encephalitis causing severe anterograde amnesia associated with rituximab, azathioprine and prednisolone combination therapy for dermatomyositis. J Neurovirol. 2017;23:508–510.
  • De Bolle L, Naesens L, De Clercq E. Update on human herpesvirus 6 biology, clinical features, and therapy. Clin Microbiol Rev. 2005;18:217–245.
  • Piukovics K, Borbényi Z, Rajda C, et al. Monitoring human herpesvirus-6 in patients with autologous stem cell transplantation. In Vivo. 2014;28:1113–1117.
  • Fule Robles JD, Cheuk DK, Ha SY, et al. Human herpesvirus types 6 and 7 infection in pediatric hematopoietic stem cell transplant recipients. Ann Transplant. 2014;19:269–276.
  • Roux J, Battistella M, Fornecker L, et al. Human herpesvirus-6 cytopathic inclusions: an exceptional and recognizable finding on skin biopsy during HHV6 reactivation after autologous stem-cell transplantation. Am J Dermatopathol. 2012;34:e73.

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