Advanced search
Publication Cover
Leukemia & Lymphoma Volume 60, 2019 - Issue 12
Submit an article Journal homepage
330
Views
3
CrossRef citations to date
0
Altmetric
Original Article

Clinical applicability of proposed algorithm for identifying individuals at risk for hereditary hematologic malignancies

Maggie CliffordBaylor Charles A. Sammons Cancer Center, Baylor University Medical Center, Dallas, TX, USA; ;The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA; ORCID Iconhttp://orcid.org/0000-0003-1993-3321
ORCID Icon,
Sarah BannonDepartment of Clinical Cancer Genetics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA;
,
Erica M. BednarDepartment of Clinical Cancer Genetics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA;
,
Jennifer CzerwinskiDepartment of Obstetrics and Gynecology, McGovern Medical School at the University of Texas at Houston, Houston, TX, USA;
,
Jessica DavisGreenwood Genetic Center, Greenville, SC, USA;
,
Leslie DunningtonDepartment of Pediatrics, McGovern Medical School at the University of Texas at Houston, Houston, TX, USA;
,
S. Shahrukh HashmiPediatric Research Center, Department of Pediatrics, McGovern Medical School at the University of Texas at Houston, Houston, TX, USA;
&
Courtney D. DiNardoDepartment of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USACorrespondence[email protected]
 show all
Pages 3020-3027 | Received 29 Nov 2018, Accepted 03 Jun 2019, Published online: 05 Jul 2019

References

  • April SEER Cancer Statistics Review. National Cancer Institute; 2016. Available from: http://seer.cancer.gov/csr/1975_2013/. Accessed 2016 April
  • Surveillance, Epidemiology, and End Results (SEER). National Cancer Institute; 2016. [cited 2016 Dec 1]. Available from: www.seer.cancer.gov.
  • Zhang MY, Churpek JE, Keel SB, et al. Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy. Nat Genet. 2015;47:180–185.
  • Godley LA, Shimamura A. Genetic predisposition to hematologic malignancies: management and surveillance. Blood. 2017;130:424–432.
  • Churpek JE, Godley LA. How I diagnose and manage individuals at risk for inherited myeloid malignancies. Blood. 2016;128:1800–1813.
  • Zhang J, Walsh MF, Wu G, et al. Germline mutations in predisposition genes in pediatric cancer. N Engl J Med. 2015;373:2336–2346.
  • Johnson AEK, Guidugli L, Arndt K, et al. Identification of genetic hereditary predisposition to hematologic malignancies by clinical next-generation sequencing. Blood. 2015;126:3854–3854.
  • Churpek JE, Lorenz R, Nedumgottil S, et al. Proposal for the clinical detection and management of patients and their family members with familial myelodysplastic syndrome/acute leukemia predisposition syndromes. Leuk Lymphoma. 2013;54:28–35.
  • Ganly P, Walker LC, Morris CM. Familial mutations of the transcription factor RUNX1 (AML1, CBFA2) predispose to acute myeloid leukemia. Leuk Lymphoma. 2004;45:1–10.
  • Dickinson RE, Griffin H, Bigley V, et al. Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency. Blood. 2011;118:2656–2658.
  • Hsu AP, Sampaio EP, Khan J, et al. Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome. Blood. 2011;118:2653–2655.
  • Ostergaard P, Simpson MA, Connell FC, et al. Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome). Nat Genet. 2011;43:929–931.
  • Shimamura A, Alter BP. Pathophysiology and management of inherited bone marrow failure syndromes. Blood Rev. 2010;24:101–122.
  • Alter BP. Diagnosis, genetics, and management of inherited bone marrow failure syndromes. ASH Educ Program Book. 2007;2007:29–39.
  • Buijs A, Poddighe P, van Wijk R, et al. A novel CBFA2 single-nucleotide mutation in familial platelet disorder with propensity to develop myeloid malignancies. Blood. 2001;98:2856–2858.
  • Fogarty PF, Yamaguchi H, Wiestner A, et al. Late presentation of dyskeratosis congenita as apparently acquired aplastic anaemia due to mutations in telomerase RNA. Lancet. 2003;362:1628–1630.
  • Owen CJ, Toze CL, Koochin A, et al. Five new pedigrees with inherited RUNX1 mutations causing familial platelet disorder with propensity to myeloid malignancy. Blood. 2008;112:4639–4645.
  • DiNardo CD, Bannon SA, Routbort M, et al. Evaluation of patients and families with concern for predispositions to hematologic malignancies within the hereditary hematologic malignancy clinic (HHMC). Clin Lymphoma Myeloma Leuk. 2016;16:417–428.e412.
  • Network NCC. Genetic/Familial High Risk Assessment: Breast and Ovarian; 2017. [cited 2017].
  • Lu KH, Wood ME, Daniels M, et al. American Society of Clinical Oncology Expert Statement: collection and use of a cancer family history for oncology providers. J Clin Oncol. 2014;32:833–840.
  • Pabst T, Eyholzer M, Haefliger S, et al. Somatic CEBPA mutations are a frequent second event in families with germline CEBPA mutations and familial acute myeloid leukemia. J Clin Oncol. 2008;26:5088–5093.
  • Taskesen E, Bullinger L, Corbacioglu A, et al. Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity. Blood. 2011;117:2469–2475.
  • Drazer MW, Kadri S, Sukhanova M, et al. Prognostic tumor sequencing panels frequently identify germ line variants associated with hereditary hematopoietic malignancies. Blood Adv. 2018;2:146–150.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.