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Letters to the Editor

A comprehensive clinical study of integrins in acute lymphoblastic leukemia indicates a role of α6/CD49f in persistent minimal residual disease and α5 in the colonization of cerebrospinal fluid

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Pages 1714-1718 | Received 30 Oct 2019, Accepted 09 Feb 2020, Published online: 28 Feb 2020

References

  • Toft N, Birgens H, Abrahamsson J, et al. Risk group assignment differs for children and adults 1-45 yr with acute lymphoblastic leukemia treated by the NOPHO ALL-2008 protocol. Eur J Haematol. 2013;90(5):404–412.
  • Akers SM, Rellick SL, Fortney JE, et al Cellular elements of the subarachnoid space promote ALL survival during chemotherapy. Leuk Res. 2011;35(6):705–711.
  • Meads MB, Hazlehurst LA, Dalton WS. The bone marrow microenvironment as a tumor sanctuary and contributor to drug resistance. Clin Cancer Res. 2008;14(9):2519–2526.
  • Shishido S, Bönig H, Kim Y-M. Role of integrin alpha4 in drug resistance of leukemia. Front Oncol. 2014;4:99.
  • Jonart LM, Ebadi M, Basile P, et al. Disrupting the leukemia niche in the central nervous system attenuates leukemia chemoresistance. Haematologica. 2019;17. DOI: 10.3324/haematol.2019.230334
  • Zhang Y, Wang H. Integrin signalling and function in immune cells. Immunology. 2012;135(4):268–275.
  • Yao H, Price TT, Cantelli G, et al. Leukaemia hijacks a neural mechanism to invade the central nervous system. Nature. 2018;560(7716):55–60.
  • Shalapour S, Hof J, Kirschner-Schwabe R, et al. High VLA-4 expression is associated with adverse outcome and distinct gene expression changes in childhood B-cell precursor acute lymphoblastic leukemia at first relapse. Haematologica. 2011;96(11):1627–1635.
  • Williams MTS, Yousafzai YM, Elder A, et al. The ability to cross the blood-cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts. Blood. 2016;127(16):1998–2006.
  • Bertoni A, Alabiso O, Galetto AS, et al. Integrins in T cell physiology. Int J Mol Sci. 2018;19(2). DOI: 10.3390/ijms19020485
  • Øbro NF, Ryder LP, Madsen HO, et al. Identification of residual leukemic cells by flow cytometry in childhood B-cell precursor acute lymphoblastic leukemia: verification of leukemic state by flow-sorting and molecular/cytogenetic methods. Haematologica. 2012;97(section 7631):137–141.
  • Bazzoni G, Carlesso N, Griffin JD, et al. Bcr/Abl expression stimulates integrin function in hematopoietic cell lines. J Clin Invest. 1996;98(2):521–528.
  • O’Connor D, Enshaei A, Bartram J, et al. Genotype-specific minimal residual disease interpretation improves stratification in pediatric acute lymphoblastic leukemia. JCO. 2018;36(1):34–43.
  • Levinsen M, Marquart HV, Groth-Pedersen L, et al. for the Nordic Society of Pediatric Hematology and Oncology (NOPHO). Leukemic blasts are present at low levels in spinal fluid in one-third of childhood acute lymphoblastic leukemia cases. Pediatr Blood Cancer. 2016;63(11):1935–1942.
  • Price RA, Johnson WW. The central nervous system in childhood leukemia: I. The arachnoid. Cancer. 1973;31(3):520–533.

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