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Leukemia & Lymphoma Volume 62, 2021 - Issue 4
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Original Articles

AML1-ETO inhibits acute myeloid leukemia immune escape by CD48

Zhiding Wanga Department of Hematology-Oncology, International Cancer Center, Shenzhen University General Hospital, Shenzhen University Health Science Center, Shenzhen, China; ;b Department of Hematology, Chinese PLA General Hospital, Beijing, ChinaORCID Iconhttps://orcid.org/0000-0001-8170-1359View further author information
ORCID Icon,
Wei Guanb Department of Hematology, Chinese PLA General Hospital, Beijing, ChinaORCID Iconhttps://orcid.org/0000-0001-5830-7089View further author information
ORCID Icon,
Mengzhen Wangb Department of Hematology, Chinese PLA General Hospital, Beijing, ChinaView further author information
,
Jinghong Chena Department of Hematology-Oncology, International Cancer Center, Shenzhen University General Hospital, Shenzhen University Health Science Center, Shenzhen, China; View further author information
,
Linlin Zhangb Department of Hematology, Chinese PLA General Hospital, Beijing, ChinaView further author information
,
Yang Xiaob Department of Hematology, Chinese PLA General Hospital, Beijing, ChinaView further author information
,
Lixin Wanga Department of Hematology-Oncology, International Cancer Center, Shenzhen University General Hospital, Shenzhen University Health Science Center, Shenzhen, China; ORCID Iconhttps://orcid.org/0000-0002-9986-9712View further author information
ORCID Icon,
Yonghui Lia Department of Hematology-Oncology, International Cancer Center, Shenzhen University General Hospital, Shenzhen University Health Science Center, Shenzhen, China; View further author information
&
Li Yua Department of Hematology-Oncology, International Cancer Center, Shenzhen University General Hospital, Shenzhen University Health Science Center, Shenzhen, China; ;b Department of Hematology, Chinese PLA General Hospital, Beijing, ChinaCorrespondence[email protected]
View further author information
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Pages 937-943 | Received 08 Sep 2020, Accepted 31 Oct 2020, Published online: 21 Nov 2020

References

  • Short NJ, Rytting ME, Cortes JE. Acute myeloid leukaemia. Lancet. 2018;392(10147):593–606.
  • Bullinger L, Dohner K, Dohner H. Genomics of acute myeloid leukemia diagnosis and pathways. J Clin Oncol. 2017;35(9):934–946.
  • Dou L, Yan F, Pang J, et al. Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia. Nat Commun. 2019;10(1):5051.
  • Messaoudene M, Frazao A, Gavlovsky PJ, et al. Patient's natural killer cells in the era of targeted therapies: role for tumor killers. Front Immunol. 2017;8:683.
  • Bjorklund AT, Carlsten M, Sohlberg E, et al. Complete remission with reduction of high-risk clones following haploidentical NK-Cell therapy against MDS and AML. Clin Cancer Res. 2018;24(8):1834–1844.
  • Hansrivijit P, Gale RP, Barrett J, et al. Cellular therapy for acute myeloid leukemia – current status and future prospects. Blood Rev. 2019;37:100578.
  • Scoville SD, Nalin AP, Chen L, et al. Human AML activates the aryl hydrocarbon receptor pathway to impair NK cell development and function. Blood. 2018;132(17):1792–1804.
  • Li Y, Gao L, Luo X, et al. Epigenetic silencing of microRNA-193a contributes to leukemogenesis in t(8;21) acute myeloid leukemia by activating the PTEN/PI3K signal pathway. Blood. 2013;121(3):499–509.
  • Fu L, Huang W, Jing Y, et al. AML1-ETO triggers epigenetic activation of early growth response gene l, inducing apoptosis in t(8;21) acute myeloid leukemia. FEBS J. 2014;281(4):1123–1131.
  • Li Y, Ning Q, Shi J, et al. A novel epigenetic AML1-ETO/THAP10/miR-383 mini-circuitry contributes to t(8;21) leukaemogenesis. EMBO Mol Med. 2017;9(7):933–949.
  • Chen G, Liu A, Xu Y, et al. The RUNX1-ETO fusion protein trans-activates c-KIT expression by recruiting histone acetyltransferase P300 on its promoter. FEBS J. 2019;286(5):901–912.
  • Lion E, Willemen Y, Berneman ZN, et al. Natural killer cell immune escape in acute myeloid leukemia. Leukemia. 2012;26(9):2019–2026.
  • Wang Z, Xiao Y, Guan W, et al. Acute myeloid leukemia immune escape by epigenetic CD48 silencing. Clin Sci (Lond). 2020;134(2):261–271.
  • Wang Z, Li G, Dou S, et al. Tim-3 promotes Listeria monocytogenes immune evasion by suppressing major histocompatibility complex class I. J Infect Dis. 2020;221(5):830–840.
  • Davis S, Meltzer PS. GEOquery: a bridge between the Gene Expression Omnibus (GEO) and BioConductor. Bioinformatics. 2007;23(14):1846–1847.
  • Lerdrup M, Johansen JV, Agrawal-Singh S, et al. An interactive environment for agile analysis and visualization of ChIP-sequencing data. Nat Struct Mol Biol. 2016;23(4):349–357.
  • Tang Z, Li C, Kang B, et al. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45(W1):W98–W102.
  • Wang L, Gural A, Sun XJ, et al. The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation. Science. 2011;333(6043):765–769.
  • Mei S, Qin Q, Wu Q, et al. Cistrome Data Browser: a data portal for ChIP-Seq and chromatin accessibility data in human and mouse. Nucleic Acids Res. 2017;45(D1):D658–D662.
  • Zheng R, Wan C, Mei S, et al. Cistrome Data Browser: expanded datasets and new tools for gene regulatory analysis. Nucleic Acids Res. 2019;47(D1):D729–D735.
  • Ning ZQ, Li ZB, Newman MJ, et al. Chidamide (CS055/HBI-8000): a new histone deacetylase inhibitor of the benzamide class with antitumor activity and the ability to enhance immune cell-mediated tumor cell cytotoxicity. Cancer Chemother Pharmacol. 2012;69(4):901–909.
  • Bowers EM, Yan G, Mukherjee C, et al. Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol. 2010;17(5):471–482.
  • Elias S, Yamin R, Golomb L, et al. Immune evasion by oncogenic proteins of acute myeloid leukemia. Blood. 2014;123(10):1535–1543.

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