Advanced search
Publication Cover
Leukemia & Lymphoma Volume 62, 2021 - Issue 7
Submit an article Journal homepage
942
Views
17
CrossRef citations to date
0
Altmetric
Letters to the Editor

Management of hemophagocytic lymphohistiocytosis (HLH) associated with chimeric antigen receptor T-cell (CAR-T) therapy using anti-cytokine therapy: an illustrative case and review of the literature

Ajay Majora Section of Hematology/Oncology at the University of Chicago, University of Chicago Comprehensive Cancer Center, Chicago, IL, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-7261-1335
ORCID Icon,
Jennifer Collinsa Section of Hematology/Oncology at the University of Chicago, University of Chicago Comprehensive Cancer Center, Chicago, IL, USA
,
Caroline Craneya Section of Hematology/Oncology at the University of Chicago, University of Chicago Comprehensive Cancer Center, Chicago, IL, USA
,
Alisa K. Heitmana Section of Hematology/Oncology at the University of Chicago, University of Chicago Comprehensive Cancer Center, Chicago, IL, USA
,
Emily Bauera Section of Hematology/Oncology at the University of Chicago, University of Chicago Comprehensive Cancer Center, Chicago, IL, USA
,
Elizabeth Zerantea Section of Hematology/Oncology at the University of Chicago, University of Chicago Comprehensive Cancer Center, Chicago, IL, USA
,
Wendy Stockb The David and Etta Jonas Center for Cellular Therapy at the University of Chicago, Chicago, IL, USA
,
Michael R. Bishopb The David and Etta Jonas Center for Cellular Therapy at the University of Chicago, Chicago, IL, USA
&
Jagoda Jasielecb The David and Etta Jonas Center for Cellular Therapy at the University of Chicago, Chicago, IL, USA
 show all
Pages 1765-1769 | Received 04 Oct 2020, Accepted 21 Jan 2021, Published online: 09 Feb 2021

References

  • Lee D, Santomasso B, Locke F, et al. ASTCT consensus grading for cytokine release syndrome and neurologic toxicity associated with immune effector cells. Biol Blood Marrow Transplant. 2019;25(4):625–638.
  • Neelapu S, Tummala S, Kebriaei P, et al. Chimeric antigen receptor T-cell therapy - assessment and management of toxicities. Nat Rev Clin Oncol. 2018;15(1):47–62.
  • Neelapu S, Locke F, Bartlett N, et al. Axicabtagene ciloleucel CAR T-cell therapy in refractory large B-cell lymphoma. N Engl J Med. 2017;377(26):2531–2544.
  • Ombrello A, Yates B, Shalabi H, et al. Experience with and management of HLH-like toxicities following chimeric antigen receptor T-cell therapy for treatment of relapsed/refractory pre-B ALL [abstract]. Arthritis Rheumatol. 2020. 72 (suppl 4). [cited 2020 Aug 12]. https://acrabstracts.org/abstract/experience-with-and-management-of-hlh-like-toxicities-following-chimeric-antigen-receptor-t-cell-therapy-for-treatment-of-relapsed-refractory-pre-b-all/.
  • Ahmed S, Furqan F, Strati P, et al. Haemophagocytic lymphohistiocytosis (HLH) in patients with large B-cell lymphoma treated with standard of care (SOC) axicabtagene ciloleucel (Axi-cel). J Clin Oncol. 2020;38(15_suppl):8057–8057.
  • Shimizu M, Nakagishi Y, Kasai K, et al. Tocilizumab masks the clinical symptoms of systemic juvenile idiopathic arthritis-associated macrophage activation syndrome: the diagnostic significance of interleukin-18 and interleukin-6. Cytokine. 2012;58(2):287–294.
  • Johnson T, Terrell C, Millen S, et al. Etoposide selectively ablates activated T cells to control the immunoregulatory disorder hemophagocytic lymphohistiocytosis. J Immunol. 2014;192(1):84–91.
  • Norelli M, Camisa B, Barbiera G, et al. Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells. Nat Med. 2018;24(6):739–748.
  • Giavridis T, van der Stegen S, Eyquem J, et al. CAR T cell-induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade. Nat Med. 2018;24(6):731–738.
  • Murthy H, Iqbal M, Chavez J, et al. Cytokine release syndrome: current perspectives. Immunotargets Ther. 2019;8:43–52.
  • La Rosée P, Horne A, Hines M, et al. Recommendations for the management of hemophagocytic lymphohistiocytosis in adults. Blood. 2019;133(23):2465–2477.
  • Wohlfarth P, Agis H, Gualdoni G, et al. Interleukin 1 receptor antagonist Anakinra, intravenous immunoglobulin, and corticosteroids in the management of critically ill adult patients with hemophagocytic lymphohistiocytosis. J Intensive Care Med. 2019;34(9):723–731.
  • Kumar B, Aleem S, Saleh H, et al. A personalized diagnostic and treatment approach for macrophage activation syndrome and secondary hemophagocytic lymphohistiocytosis in adults. J Clin Immunol. 2017;37(7):638–643.
  • Shah NN, Highfill SL, Shalabi H, et al. CD4/CD8 T-cell selection affects chimeric antigen receptor (CAR) T-cell potency and toxicity: updated results from a phase I anti-CD22 CAR T-cell trial. J Clin Oncol. 2020;38(17):1938–1950.
  • Strati P, Ahmed S, Kebriaei P, et al. Clinical efficacy of anakinra to mitigate CAR T-cell therapy-associated toxicity in large B-cell lymphoma. Blood Adv. 2020;4(13):3123–3127.
  • Jatiani SS, Aleman A, Madduri D, et al. Myeloma CAR-T CRS management with IL-1R antagonist anakinra. Clin Lymphoma Myeloma Leuk. 2020;20(9):632–636.e1.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.