Advanced search
Publication Cover
Leukemia & Lymphoma Volume 63, 2022 - Issue 11
Submit an article Journal homepage
379
Views
2
CrossRef citations to date
0
Altmetric
Letters to the Editor

The safety of concurrent intrathecal chemotherapy during blinatumomab in adults with acute lymphoblastic leukemia

Dat Ngoa Department of Pharmacy, City of Hope, Duarte, CA, USACorrespondence[email protected]
,
Salman Otoukeshb Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA
,
Anthony S. Steinb Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA
,
Stephen Formanb Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USAORCID Iconhttps://orcid.org/0000-0002-2803-4152
ORCID Icon,
Vinod Pullarkatb Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USAORCID Iconhttps://orcid.org/0000-0001-9129-3424
ORCID Icon &
Ibrahim Aldossb Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USAORCID Iconhttps://orcid.org/0000-0001-9564-4498
ORCID Icon
Pages 2754-2756 | Received 18 May 2022, Accepted 13 Jun 2022, Published online: 21 Jun 2022

References

  • Aldoss I, Forman SJ. How I treat adults with advanced acute lymphoblastic leukemia eligible for CD19-targeted immunotherapy. Blood. 2020;135(11):804–813.
  • Kantarjian HM, Stein AS, Bargou RC, et al. Blinatumomab treatment of older adults with relapsed/refractory B-precursor acute lymphoblastic leukemia: results from 2 phase 2 studies. Cancer. 2016;122(14):2178–2185.
  • Lenk L, Alsadeq A, Schewe DM. Involvement of the Central nervous system in acute lymphoblastic leukemia: opinions on molecular mechanisms and clinical implications based on recent data. Cancer Metastasis Rev. 2020;39(1):173–187.
  • Klinger M, Zugmaier G, Nägele V, et al. Adhesion of T cells to endothelial cells facilitates blinatumomab-associated neurologic adverse events. Cancer Res. 2020;80(1):91–101.
  • Alfayez M, Kantarjian HM, Short NJ, et al. Safety and efficacy of blinatumomab in patient with Central nervous system (CNS) disease: a single institution experience. Blood. 2018;132(Supplement 1):2702–2702.
  • Aldoss I, Otoukesh S, Zhang J, et al. Extramedullary disease relapse and progression after blinatumomab therapy for treatment of acute lymphoblastic leukemia. Cancer. 2022;128(3):529–535.
  • Chen J, Ngo D, Rosenthal J. Case report of neurotoxicity with blinatumomab and concurrent intrathecal chemotherapy in second relapse of acute lymphoblastic leukemia with Central nervous system disease. J Oncol Pharm Pract. 2019;25(8):2027–2030.
  • Foa R, Bassan R, Vitale A, GIMEMA Investigators, et al. Dasatinib-blinatumomab for Ph-positive acute lymphoblastic leukemia in adults. N Engl J Med. 2020;383(17):1613–1623.
  • Badar T, Szabo A, Advani A, et al. Real-world outcomes of adult B-cell actue lymphocytic leukemia patients treated with blinatumomab. Blood Adv. 2020;4(10):2308–2316.
  • Short NJ, Kantarjian H, Konopleva M, et al. Updated results of a phase II study of ponatinib and blinatumomab for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood. 2021;138(Supplement 1):2298–2298.
  • Aqel A, Fakhreddine O, Atoui A, et al. The use of intrathecal chemotherapy and dexamethasone for secondary prevention of blinatumomab-related neurotoxicity. Curr Res Transl Med. 2021;69(2):103285.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.