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Original Articles

Outcomes with allogeneic hematopoietic stem cell transplantation in TP53-mutated acute myeloid leukemia: a systematic review and meta-analysis

ORCID Icon, , , , , , , , , , , & ORCID Icon show all
Pages 3409-3417 | Received 13 Jun 2022, Accepted 31 Aug 2022, Published online: 15 Sep 2022

References

  • Yoshizato TY, Atsuta Y, Shiozawa Y, et al. Genetic abnormalities in myelodysplasia and secondary acute myeloid leukemia: impact on outcome of stem cell transplantation. Blood. 2017;129(17):2347–2358.
  • Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature. 2000;408(6810):307–310.
  • Boettcher S, Miller PG, Sharma R, et al. A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies. Science. 2019;365(6453):599–604.
  • Brown CJ, Lain S, Verma CS, et al. Awakening guardian angels: drugging the p53 pathway. Nat Rev Cancer. 2009;9(12):862–873.
  • Welch JS, Petti AA, Miller CA, et al. TP53 and decitabine in acute myeloid leukemia and myelodysplastic syndromes. N Engl J Med. 2016;375(21):2023–2036.
  • Schoch C, Kern W, Kohlmann A, et al. Acute myeloid leukemia with a complex aberrant karyotype is a distinct biological entity characterized by genomic imbalances and a specific gene expression profile. Genes Chromosomes Cancer. 2005;43(3):227–238.
  • Olivier M, Hollstein M, Hainaut P. TP53 mutations in human cancers: origins, consequences, and clinical use. Cold Spring Harb Perspect Biol. 2010;2(1):a001008.
  • Kim K, Maiti A, Loghavi S, et al. Outcomes of TP53-mutant acute myeloid leukemia with decitabine and venetoclax. Cancer. 2021;127(20):3772–3781.
  • Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009;339:b2700.
  • Schwarzer G. Meta: an R package for meta-analysis. R News. 2007;7(3):40–45.
  • DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7(3):177–188.
  • Middeke JM, Herold S, Rücker-Braun E, et al. TP53 mutation in patients with high-risk acute myeloid leukaemia treated with allogeneic haematopoietic stem cell transplantation. Br J Haematol. 2016;172(6):914–922.
  • Luskin MR, Carroll M, Lieberman D, et al. Clinical utility of next-generation sequencing for oncogenic mutations in patients with acute myeloid leukemia undergoing allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2016;22(11):1961–1967.
  • Christopher J, Gibson M, Vincent TH III, et al. Genetic ontogeny defines distinct prognostic subgroups in AML patients age 60 and older following hematopoietic stem cell transplantation. Blood. 2017;130(Suppl. 1):3310.
  • Grimm J, Jentzsch M, Bill M, et al. Prognostic impact of the ELN2017 risk classification in patients with AML receiving allogeneic transplantation. Blood Adv. 2020;4(16):3864–3874.
  • Yuho Najima M, Daichi Sadato M, Yuka Harada MP, et al. Presence of TP53 mutation and monosomal karyotype predict the outcome of patients with acute myeloid leukemia in non-remission at allogeneic stem cell transplantation. Blood. 2018;132(Suppl. 1):2168–2168.
  • Short NJ, Montalban-Bravo G, Hwang H, et al. Prognostic and therapeutic impacts of mutant TP53 variant allelic frequency in newly diagnosed acute myeloid leukemia. Blood Adv. 2020;4(22):5681–5689.
  • Justin Loke ML, Craddock C, Cornelissen J, et al. Disease risk in tp53 mutant acute myeloid leukaemia following an allogeneic stem cell transplant is dependent on the presence of co-existing cytogenetic features: a report from the ALWP of the EBMT. EHA. 2021;324640;S232.
  • Badar T, Atallah E, Shallis RM, et al. Outcomes of TP53-mutated AML with evolving frontline therapies: impact of allogeneic stem cell transplantation on survival. Am J Hematol. 2022;97(7):E232–E235.
  • Yue X, Zhao Y, Xu Y, et al. Mutant p53 in cancer: accumulation, gain-of-function, and therapy. J Mol Biol. 2017;429(11):1595–1606.
  • Onyee Chan M, Hunter A, Talati C, et al. Impact of TP53 gene mutation clearance and conditioning intensity on outcome in MDS or AML patients prior to allogeneic stem cell transplantation. Blood. 2019;134(Suppl. 1):149.
  • Döhner H, Estey E, Grimwade D, et al. Diagnosis and management of AML in adults: 2017 ELN recommendations from an International Expert Panel. Blood. 2017;129(4):424–447.
  • Murdock HM, Kim HT, Hambley BC, et al. Genetic alterations at diagnosis predict outcome of AML patients age 60 or older undergoing allogeneic transplantation in first remission. Blood. 2019;134(Suppl. 1):48.
  • Britt A, Mohyuddin GR, McClune B, et al. Acute myeloid leukemia or myelodysplastic syndrome with chromosome 17 abnormalities and long-term outcomes with or without hematopoietic stem cell transplantation. Leuk Res. 2020;95:106402.
  • Poiré X, Labopin M, Maertens J, et al. Allogeneic stem cell transplantation in adult patients with acute myeloid leukaemia and 17p abnormalities in first complete remission: a study from the acute leukemia working party (ALWP) of the European Society for Blood and Marrow Transplantation (EBMT). J Hematol Oncol. 2017;10(1):20.
  • Mori J, Yanada M, Uchida N, et al. Outcomes of allogeneic hematopoietic cell transplantation in acute myeloid leukemia patients with abnormalities of the short arm of chromosome 17. Biol Blood Marrow Transplant. 2017;23(8):1398–1404.
  • Döhner H, Weisdorf DJ, Bloomfield CD. Acute myeloid leukemia. N Engl J Med. 2015;373(12):1136–1152.
  • Mishra A, Tamari R, DeZern AE, et al. Phase II trial of eprenetapopt (APR-246) in combination with azacitidine (AZA) as maintenance therapy for TP53 mutated AML or MDS following allogeneic stem cell transplantation (SCT). Blood. 2021;138(Suppl. 1):409.
  • Byrne MT, Kurian TJ, Patel DA, et al. Non-relapse mortality in TP53-mutated MDS/AML –a multi-center collaborative study. Blood. 2021;138(Suppl. 1):2922.

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