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From Research to Practice

To Test OR Not to Test

An Update on UGT1A1 Testing

Pages 20-22 | Published online: 31 Jul 2017

References

  • McLeod HL, Parodi L, Sargent DJ, et al. UGT1A1*28, toxicity and outcome in advanced colorectal cancer: Results from Trial N9741. J Clin Oncol. 2006 ASCO Annual Meeting Proceedings Part I, Vol. 24, No. 18S (June 20 Supplement), 2006: 3520.
  • Hoskins JM and McLeod HL. UGT1A1*28 and irinotecan-induced neutropenia: dose matters. (Submitted for publication.)
  • Goldberg RM, Sargent DJ, Morton RF, et al Randomized controlled trial of reduced-dose bolus fluorouracil plus leucovorin and irinotecan or infused fluorouracil plus leucovorin and oxaliplatin in patients with previously untreated metastatic colorectal cancer: A North American Intergroup Trial. J. Clin Oncol. 2006;24(21):3347–53.
  • McLeod HL, Watters JW: Irinotecan pharmacogenetics: Is it time to intervene? J Clin Oncol. 2004;22(8):1356–1359.
  • Meyerhardt JA, Kwok A, Ratain MJ, et al. Relationship of baseline serum bilirubin to efficacy and toxicity of single-agent irinotecan in patients with metastatic colorectal cancer. J Clin Oncol. 2004;22(8):1439–46.

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